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chr8:119,737,284-122,078,334

Best TWAS P=2.24e-10 · Best GWAS P=7.1e-12 conditioned to 2.56e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Brain Cerebellar Hemisphere	DEPTOR	0.32	0.15	lasso	8	0.29	3.4e-08	-5.4	6.3	2.2e-10	0.34	0.06	0.90	TRUE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NOV	0.06	0.00	blup	42	0.03	4.3e-04	5.6	6.1	1.1e-09	0.13	0.01	0.68	TRUE
18	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DEPDC6	0.07	0.02	enet	17	0.04	1.6e-04	-5.7	6.1	8.5e-10	0.22	0.25	0.10	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	DEPDC6	0.03	0.03	blup	146	0.03	3.6e-04	5.6	-5.8	6.9e-09	-0.76	0.04	0.90	FALSE
6	GTEx	Cells Transformed fibroblasts	NOV	0.10	0.04	enet	30	0.03	3.7e-03	5.2	5.8	8.4e-09	0.14	0.04	0.92	FALSE
8	GTEx	Colon Sigmoid	DEPTOR	0.28	0.22	lasso	4	0.23	1.7e-08	-5.8	-5.8	8.5e-09	-0.39	0.67	0.27	FALSE
15	GTEx	Skin Sun Exposed Lower leg	DEPTOR	0.07	0.03	enet	7	0.03	8.9e-04	-5.4	-5.7	1.1e-08	-0.57	0.40	0.31	FALSE
4	GTEx	Brain Cerebellum	RP11-760H22.2	0.20	0.09	lasso	2	0.09	1.3e-03	-5.5	5.7	1.5e-08	0.53	0.07	0.54	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	DEPTOR	0.32	0.36	enet	19	0.31	1.1e-11	-5.3	-5.6	1.8e-08	-0.10	0.84	0.16	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	RP11-760H22.2	0.10	0.11	lasso	3	0.10	5.5e-13	-5.5	5.6	2.1e-08	0.53	0.88	0.12	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	RP11-760H22.2	0.36	0.30	lasso	5	0.24	2.8e-09	-5.3	-5.6	2.2e-08	-0.10	0.84	0.16	FALSE
7	GTEx	Colon Sigmoid	NOV	0.15	0.16	lasso	4	0.15	6.6e-06	5.5	5.6	2.4e-08	0.12	0.03	0.95	FALSE
13	GTEx	Esophagus Muscularis	RP11-760H22.2	0.28	0.16	lasso	5	0.17	8.9e-11	-5.5	-5.6	2.5e-08	-0.12	0.87	0.13	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	DSCC1	0.13	0.04	blup	54	0.09	4.8e-09	-5.4	5.5	3.2e-08	0.35	0.02	0.98	FALSE
14	GTEx	Pancreas	DEPTOR	0.17	0.12	enet	14	0.14	2.4e-06	-5.5	-5.5	3.8e-08	-0.08	0.77	0.19	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	NOV	0.04	0.05	blup	42	0.05	8.7e-06	5.6	5.5	4.8e-08	0.10	0.01	0.99	FALSE
12	GTEx	Esophagus Muscularis	DEPTOR	0.28	0.30	lasso	2	0.28	2.1e-17	-5.5	-5.5	5.0e-08	-0.10	0.85	0.15	FALSE
3	GTEx	Brain Cerebellum	DEPTOR	0.24	0.22	lasso	3	0.17	7.9e-06	-5.4	5.4	5.9e-08	0.42	0.32	0.29	FALSE
1	GTEx	Adipose Subcutaneous	RP11-760H22.2	0.16	0.11	enet	12	0.12	8.5e-10	-5.3	5.4	6.0e-08	0.57	0.71	0.29	FALSE
16	GTEx	Thyroid	COL14A1	0.10	0.02	enet	14	0.02	2.3e-02	-2.4	5.4	6.7e-08	0.29	0.18	0.09	FALSE
9	GTEx	Colon Transverse	DEPTOR	0.17	0.08	lasso	5	0.06	8.8e-04	-5.3	-5.2	1.8e-07	-0.12	0.65	0.13	FALSE
5	GTEx	Cells Transformed fibroblasts	DSCC1	0.10	0.02	lasso	5	0.02	9.4e-03	3.0	5.2	2.7e-07	0.24	0.20	0.05	FALSE