Hub : Genes

DEPDC6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0740	0.0350	1.2e-03	0.022	0.021	0.042	NA	0.036	5.1e-03	6.8e-03	1.6e-04	NA	4.5e-04
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.1068	0.0537	2.7e-04	0.017	0.052	0.051	NA	0.037	4.2e-03	1.4e-06	2.2e-06	NA	4.5e-05
3	TCGA	Brain Lower Grade Glioma	0.0973	0.0427	4.0e-05	0.047	0.034	0.049	NA	0.042	4.6e-06	7.7e-05	3.1e-06	NA	1.5e-05
4	TCGA	Lung Adenocarcinoma	0.0274	0.0144	2.3e-03	0.029	0.027	0.023	NA	0.024	2.0e-04	3.6e-04	9.0e-04	NA	7.2e-04
5	TCGA	Lung Squamous Cell Carcinoma	0.0439	0.0252	7.9e-03	0.018	0.010	0.022	NA	0.014	3.5e-03	2.2e-02	1.4e-03	NA	7.8e-03
6	TCGA	Testicular Germ Cell Tumors	0.1880	0.0700	1.1e-05	0.041	0.109	0.048	NA	0.075	1.4e-02	1.1e-04	8.4e-03	NA	1.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.1	1.7	3.5	1.2	1.0	1.9	-1.7	-1.0	0.9
Bipolar Disorder or Schizophrenia	0.6	1.5	3.0	1.2	0.8	1.7	-0.9	-0.5	1.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.4	0.3	-1.2	-0.5	1.1	0.2	0.8
Depression (Nagel 2018)	0.8	1.2	2.4	0.1	0.5	1.6	-1.5	-0.9	1.3
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.9	-1.1	0.6	0.3	1.0	1.7	-1.7
Neuroticism (Nagel 2018)	1.1	2.6	6.8	-0.5	-1.5	-2.2	2.6	1.2	0.3
Schizophrenia (2018)	0.2	0.5	2.2	0.6	0.2	0.6	0.2	0.2	1.5
Schizophrenia vs Biploar Disorder	0.3	0.3	0.9	-0.2	-0.9	-0.5	0.5	-0.0	-0.8
Worry (Nagel 2018)	2.5	5.2	13.5	-1.4	-1.3	-3.7	3.1	1.9	-0.9
Alzheimer’s Disease (in mother)	0.8	0.9	2.0	-0.7	-1.4	1.2	-0.5	-0.0	-1.1
Alzheimer’s Disease (in father)	1.7	1.9	3.9	-2.0	-1.6	-1.2	1.3	0.8	-1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	2.3	-1.3	-1.5	0.4	0.3	0.6	-1.2
Crohns Disease (2017)	0.4	0.9	1.5	-0.6	1.1	1.2	-0.1	-1.2	-1.0
Irritable Bowel Disease (IBD)	0.8	1.8	5.9	-1.6	0.6	1.1	-0.9	-2.4	-0.4
Ulcerative Colitis (UC)	1.1	2.1	5.8	-2.4	-0.5	0.2	-1.1	-2.4	-0.1
Major Depression (MDD)	0.9	1.1	2.3	-0.2	1.5	0.0	-1.4	0.0	1.4
Reaction Time	1.2	2.3	9.8	3.1	0.3	-0.6	-0.2	1.4	1.3
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.1	0.6	-0.5	0.4	0.7	0.0
Breast Cancer	1.7	4.2	13.7	-0.4	3.7	2.7	-1.8	0.2	0.6
Ovarian Cancer	0.2	0.3	1.0	0.3	1.0	0.6	0.0	0.3	0.7
Prostate Cancer	0.2	0.3	1.0	0.2	0.2	-0.4	1.0	0.4	-0.3
Age at First Birth	0.7	1.0	3.2	-1.8	-0.3	0.9	0.6	0.7	-1.0
Bipolar Disorder (2011)	0.5	0.5	2.1	-0.3	0.5	1.4	0.1	-0.6	0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	0.3	0.2	0.0	-0.6	-0.8	0.7
Coronary Artery Disease (CAD)	1.0	1.2	4.5	-2.1	-0.1	-0.2	-1.1	-0.9	0.8
Crohns Disease (2012)	0.4	0.6	1.3	-1.1	0.6	0.1	0.8	-0.7	-1.0
Mean Putamen Volume	3.8	4.4	11.1	-3.0	-2.2	-0.2	0.2	-0.8	-3.3
Fasting Glucose	0.4	0.5	1.3	-0.3	-0.4	0.5	-1.1	-1.1	0.2
HbA1C	0.7	0.8	2.4	-0.4	-1.3	-0.6	0.2	1.6	0.2
HDL Cholesterol	0.7	1.2	3.2	1.2	1.3	1.8	0.5	0.6	-0.3
LDL Cholesterol	0.5	0.7	2.4	0.4	-0.4	-1.5	0.0	1.0	0.8
Lupus	0.2	0.3	1.2	0.3	-0.4	0.5	0.3	1.1	0.2
Neuroticism (2016)	0.9	1.3	3.0	-1.7	-0.9	-1.3	1.4	0.3	0.3
Primary Biliary Cirrhosis	1.1	1.6	3.5	1.9	0.1	1.6	-1.6	-0.3	1.0
Rheumatoid Arthritis	1.4	2.0	4.9	1.1	1.3	-1.2	1.2	1.1	2.2
Schizophrenia (2014)	0.3	0.7	2.8	0.6	-0.6	0.6	-0.5	-0.2	1.7
Triglycerides	0.4	0.6	2.4	-0.7	-1.6	0.5	-0.2	-0.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.1	0.5	-0.0	-0.6	-0.1	-0.5
Ulcerative Colitis	0.8	1.2	4.2	-2.0	-0.4	-0.1	-0.7	-1.5	0.2
Blood Eosinophil Count	0.1	0.8	2.9	-1.1	-0.0	-0.3	0.4	-0.5	-1.7
Blood Platelet Count	1.7	19.6	37.7	6.1	3.2	2.5	-5.8	-2.3	5.0
Blood Red Count	0.4	3.5	16.0	-0.6	0.9	-0.0	-1.6	-4.0	1.2
Blood White Count	0.7	5.3	8.0	2.1	1.8	2.8	-2.5	-1.4	2.8
Heel T-Score	1.0	8.3	22.0	3.1	0.6	2.7	-4.7	-0.1	3.3
BMI	0.5	3.0	8.1	0.5	1.1	1.4	-1.2	-2.2	2.8
Height	2.1	39.8	116.6	-2.5	-5.5	-4.0	6.5	5.3	-10.8
Waist Hip Ratio (WHR)	0.2	1.0	4.9	0.2	-0.6	-0.8	-2.2	-0.0	0.1
Systolic Blood Pressure	0.9	4.7	17.5	-2.3	-1.0	-1.1	1.7	0.6	-4.2
Smoking Status	0.8	1.8	6.9	-0.0	-1.0	1.7	0.1	-0.5	-2.6
Allergy or Eczema	0.2	0.5	1.2	-1.1	-0.2	0.4	-0.5	-0.5	-1.1
Cardiovascular Disease	0.7	2.4	4.9	-2.2	-0.8	0.6	-1.4	-1.4	-2.1
Hypothyroidism (self reported)	1.3	2.9	8.5	-0.8	-0.7	-2.7	2.9	0.8	-0.3
Respiratory disease	2.0	4.4	11.0	1.4	1.9	1.8	-3.3	-2.2	1.4
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.8	-2.2	0.4	0.1	-1.6	-2.0	0.1
Lung FEV1/FVC ratio	2.1	10.6	43.7	1.2	1.7	-0.8	-2.3	-3.1	6.6
Lung FVC	0.7	3.8	12.1	0.4	-1.0	-1.6	2.5	3.5	-0.7
Neuroticism	1.2	3.0	10.6	0.0	-1.1	-3.3	2.4	0.4	0.4
Chronotype (morning person)	0.8	1.9	3.7	-0.4	1.7	-0.4	-1.9	-1.1	1.8
Hair Pigment	0.0	0.9	1.9	-1.1	-1.4	-0.1	1.4	0.4	-0.6
Tanning	0.1	0.8	3.6	-0.7	-0.3	0.7	-0.2	0.5	-1.9
Hand grip strength (left)	0.2	0.5	2.2	-1.5	-0.4	0.2	-0.0	0.2	-0.9
Number of treatments/medications taken	0.5	0.9	3.5	-1.0	-0.2	-0.2	0.8	0.3	-1.9
Average weekly spirits intake	0.4	0.5	1.2	0.3	0.4	1.1	-0.2	-0.8	0.9
Sensitivity / hurt feelings	0.5	0.8	2.8	-0.9	-0.9	-0.2	1.7	-0.7	-0.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	-0.6	-1.0	1.4	-0.8	0.1	0.4
Hearing difficulty/problems: Yes	2.0	3.0	7.1	0.9	2.2	-0.7	-2.1	-0.1	2.7
Relative age of first facial hair	1.3	2.7	12.2	1.2	0.7	-3.5	0.7	0.3	-1.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.2	0.7	0.4	-0.5	0.1	1.8	1.7
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.8	0.7	1.9	1.9	-1.7	0.0	0.5
Ever had hysterectomy (womb removed)	0.4	0.4	1.6	-0.6	0.5	-0.1	-1.3	-0.2	-0.4
Systolic blood pressure, automated reading	2.3	6.8	15.0	-2.8	-1.1	-1.6	3.4	1.7	-3.9
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	5.1	-1.2	-0.6	-0.8	1.2	2.3	-1.3
Angina	0.3	0.3	1.8	0.3	0.0	-0.1	-0.2	0.4	-1.3
Medication for hormone replacement therapy	1.7	1.9	7.0	-0.2	0.2	-1.1	1.3	2.7	-1.0
Vitamin and mineral supplements	0.3	0.4	1.0	-1.0	-0.0	-0.8	-0.2	-0.1	-0.7
Supplements: Zinc	0.4	0.4	1.1	0.7	-0.5	-0.4	0.6	1.0	-0.3
Medication: Co-codamol	0.4	0.5	1.1	1.0	1.0	0.2	-0.5	0.4	0.7
Medication: Metformin	1.1	1.6	4.9	-2.2	-0.3	-0.1	-1.4	-1.2	1.0
Diabetes (father)	1.3	1.6	3.4	-1.7	-0.9	-1.8	1.2	0.2	-0.8
Diabetes (mother)	0.7	0.9	2.4	-1.5	0.8	-0.6	0.8	-0.1	-1.2
Severe depression (siblings)	0.7	0.8	1.6	0.6	-0.9	-0.6	1.2	1.3	-0.6
Pack years adult smoking proportion	1.4	2.2	4.7	0.2	0.9	1.8	-2.2	-1.8	1.0
Impedance of leg (right)	0.2	1.1	3.9	-0.9	-0.0	-0.1	-1.3	-2.0	-0.5
Leg fat-free mass (left)	0.5	2.4	5.2	-0.4	-1.1	-0.9	2.2	1.6	-2.3
Trunk fat percentage	0.6	2.2	8.7	-0.8	0.2	0.8	-1.3	-2.9	1.3
Hand grip strength (right)	0.6	1.7	4.1	-2.0	-1.2	-0.4	0.9	1.3	-1.5
Townsend deprivation index at recruitment	2.4	3.4	9.1	1.3	1.3	1.7	-1.9	-1.1	3.0
Current tobacco smoking	1.0	1.6	6.4	0.5	-0.4	2.5	-0.9	-0.9	-1.1
Average weekly fortified wine intake	0.3	0.3	0.7	0.6	0.5	0.7	0.1	0.8	-0.5
Maternal smoking around birth	0.1	0.1	0.2	-0.2	0.4	0.5	-0.4	0.1	0.2
Fed-up feelings	0.3	0.5	1.9	-0.4	-1.4	-0.6	0.5	-0.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.5	-0.1	-0.3	1.2	-1.2	-1.0	0.5
Relative age voice broke	1.2	1.8	6.1	1.0	0.6	-2.5	1.3	0.3	-1.2
Taking other prescription medications	0.2	0.4	0.6	-0.8	0.1	-0.4	0.8	0.7	0.5
Age when periods started (menarche)	1.8	4.3	9.2	-0.9	-1.3	-1.1	2.1	3.0	-3.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	-1.0	1.2	0.1	-0.1	-0.7	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	7.1	2.7	-0.3	0.0	-1.3	-0.4	0.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.4	-0.3	1.1	-0.3	0.2	1.5	0.5
Qualifications: CSEs or equivalent	0.6	0.8	3.5	0.3	0.2	0.1	-1.9	-0.5	1.0
Serious illness, injury or assault to yourself	0.8	0.9	2.5	-0.5	-0.5	1.3	0.8	-0.6	-1.6
High blood pressure	0.6	1.6	4.6	-1.9	-0.1	-0.4	-0.4	-1.3	-2.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.3	-1.8	0.0	0.9	-0.7	-0.0	-0.3
Multivitamins +/- minerals	1.1	1.3	2.4	1.5	1.0	1.1	-1.0	-0.4	1.6
Stomach or abdominal pain in last month	0.4	0.5	1.7	0.4	0.2	-1.3	0.4	0.8	0.4
Supplements: Glucosamine	0.1	0.2	0.5	0.2	-0.1	-0.4	-0.3	0.7	-0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.9	-1.0	-1.4	-0.3	1.0	-0.1	-0.3
Medication: Atenolol	0.6	0.8	3.0	-0.5	-0.5	-0.5	0.8	-0.3	-1.7
Medication: Levothyroxine sodium	0.6	1.0	2.1	-0.9	-0.1	-1.4	1.4	1.0	0.6
Sitting height	0.9	6.2	22.8	-0.6	-0.9	-0.9	2.4	2.5	-4.8
Chronic bronchitis/emphysema (father)	2.1	2.5	5.2	-2.0	-0.9	2.0	0.1	-0.7	-2.3
High blood pressure (mother)	0.5	0.6	1.6	-1.3	-0.2	-1.2	0.4	0.5	-0.5
Body mass index (BMI)	0.4	1.6	5.4	-0.1	0.2	0.8	-1.0	-1.6	2.3
Impedance of leg (left)	0.2	1.2	4.0	-1.2	0.0	-0.1	-1.2	-2.0	-0.1
Leg predicted mass (left)	0.5	2.5	4.9	-0.4	-1.1	-1.0	2.2	1.6	-2.2
Trunk fat mass	0.2	0.8	3.6	-0.7	0.0	0.3	-0.5	-1.9	0.5
Waist circumference	0.3	1.3	3.1	0.2	0.6	0.8	-1.6	-1.8	0.9
Number of incorrect matches in round	0.3	0.5	1.5	0.8	0.7	0.2	-0.5	-0.6	-1.2
Past tobacco smoking	0.5	0.9	1.4	-1.2	0.6	-1.2	1.0	1.0	0.7
Alcohol usually taken with meals	1.9	3.1	4.7	1.3	2.2	1.6	-1.8	-1.8	1.6
Nervous feelings	0.3	0.6	2.7	0.7	0.3	-1.6	0.5	0.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	4.9	-1.4	-2.2	1.4	0.4	0.6	-1.3
Hearing difficulty/problems with background noise	2.0	3.2	11.9	0.2	1.2	0.1	-3.5	-1.7	1.6
Hair/balding pattern: Pattern 2	0.7	0.9	3.7	0.2	-0.1	-0.4	-1.3	-1.9	0.1
Had menopause	0.7	0.9	1.7	-0.5	0.7	1.3	-1.3	-1.0	0.5
Had other major operations	3.9	4.8	11.9	1.4	1.3	2.7	-3.4	-2.1	1.4
Forced vital capacity (FVC)	1.5	5.9	9.5	-1.2	-2.2	-1.8	3.1	2.9	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	5.9	2.4	-0.2	0.6	-1.5	-0.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	-0.7	-0.9	0.3	-0.7	-0.0	-0.7
Qualifications: None of the above	0.4	0.9	2.2	0.9	-1.5	-0.5	-1.1	-0.7	0.7
Financial difficulties in last 2 years	0.6	0.8	2.5	-0.8	-1.6	0.1	0.6	1.1	-0.3
Mouth/teeth dental problems	0.2	0.3	0.8	-0.2	-0.8	0.6	-0.3	-0.9	-0.1
Heart attack	3.5	4.5	11.3	-2.3	-2.2	-1.6	1.7	0.6	-3.4
Allergy	0.4	0.9	2.2	1.2	-0.8	-1.1	1.5	0.5	-0.2
Pain all over the body in last month	2.6	2.8	9.0	0.9	0.1	3.0	-2.1	-1.2	1.2
Diabetes (self-reported)	1.3	2.1	8.8	-3.0	-0.9	0.2	-0.5	-1.6	-0.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.9	-1.3	-1.4	0.1	-1.4	-0.6	1.3
Medication: Ramipril	1.1	1.5	5.0	-2.2	-1.8	-0.5	-0.2	-0.5	0.0
Medication: Simvastatin	0.6	0.8	3.2	-0.5	0.2	0.4	-0.8	-1.8	-0.9
Fluid intelligence score	0.2	0.3	1.5	0.3	1.2	0.5	0.1	-0.1	0.4
Illnesses of siblings	0.9	1.3	2.3	0.0	1.3	1.4	-1.1	-1.5	0.9
Neuroticism score	0.4	0.9	2.2	0.4	-0.7	-1.5	1.5	0.6	0.1
Weight	0.1	0.3	0.7	-0.3	-0.6	-0.5	0.8	0.0	-0.7
Impedance of arm (right)	0.3	1.4	3.6	-0.9	-0.0	0.4	-1.8	-1.9	-0.6
Arm fat percentage (right)	0.9	3.4	7.5	-0.7	0.4	1.2	-1.9	-2.7	2.6
Trunk fat-free mass	1.0	5.7	10.7	0.2	-0.8	-1.9	3.3	3.0	-3.2
Hip circumference	0.1	0.4	1.1	0.1	0.5	1.0	-0.4	-0.9	0.4
Time employed in main current job	1.8	2.1	4.5	-1.1	-1.3	-0.3	2.0	1.1	-2.1
Alcohol intake versus 10 years previously	0.2	0.3	1.2	-0.4	0.1	0.0	-0.4	-1.1	0.2
Father’s age at death	2.0	2.6	5.6	0.9	1.0	1.7	-2.4	-1.8	1.4
Worrier / anxious feelings	1.2	2.3	6.1	-0.2	-0.1	-2.5	2.2	1.6	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.3	-0.4	-1.1	-0.7	0.2	0.4	-1.1
Falls in the last year	0.7	1.0	3.5	-0.1	-0.5	1.9	-0.9	-1.1	-0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.2	-0.6	0.5	0.7	-0.2	0.9
Number of live births	0.4	0.6	2.3	-0.0	0.9	-0.3	-0.6	1.5	-0.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.5	-0.6	-1.9	-1.2	1.5	1.3	-0.6
Pulse rate	0.9	1.5	6.6	0.4	1.0	-0.7	-0.8	0.2	2.6
Happiness	0.4	0.5	1.4	-0.8	-0.1	0.8	0.3	1.2	-0.4
Noisy workplace	0.6	0.7	3.1	-0.7	-1.8	0.0	-0.6	0.5	0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.1	0.5	-1.6	-0.8	0.9	1.7	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.1	0.3	0.5	1.4	-1.0	0.3	1.0
Mouth/teeth dental problems: Dentures	0.8	1.3	2.4	1.5	1.5	-0.6	-0.6	-0.6	1.4
Asthma	2.0	4.0	12.7	0.3	1.7	1.7	-3.6	-2.3	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	5.1	-1.2	-2.3	0.6	0.6	0.0	-1.6
Medication: Cholesterol lowering	1.6	2.5	4.7	-1.9	-0.8	-1.3	1.7	1.3	-2.2
Depression (self-reported)	2.1	2.5	8.1	-0.9	-2.8	-1.2	1.9	0.8	-0.6
Medication: Lansoprazole	1.3	1.5	4.4	1.1	0.6	-2.1	0.0	0.4	1.6
Prospective memory result	0.5	0.6	3.2	-0.3	0.5	0.1	-0.4	-1.8	-0.0
Lung cancer (father)	0.6	0.7	1.6	1.0	-0.2	-1.0	-0.8	-1.3	0.4
Illnesses of mother	0.2	0.2	0.9	1.0	-0.4	-0.1	0.1	0.5	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.2	-1.0	-2.0	-2.1	1.2	0.8	-1.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	-0.1	1.0	-0.6	-0.8	-0.6	1.1
Impedance of arm (left)	0.3	1.4	3.4	-1.2	-0.6	0.2	-1.6	-1.9	-0.7
Arm fat mass (right)	0.2	1.0	2.4	-0.8	-0.1	0.3	-1.0	-1.5	1.4
Trunk predicted mass	1.0	5.6	10.7	0.2	-0.8	-2.0	3.3	2.9	-3.2
Standing height	1.6	15.7	46.1	-1.1	-2.4	-3.4	4.3	3.4	-6.8
Length of working week for main job	0.4	0.4	0.9	-0.7	-0.7	-0.9	-0.5	-0.3	0.3
Exposure to tobacco smoke at home	0.2	0.2	0.5	-0.7	0.6	0.0	-0.3	-0.2	0.6
Breastfed as a baby	1.8	2.3	4.6	-1.0	-0.7	-2.0	1.3	1.3	-2.1
Tense / ‘highly strung’	1.1	1.8	2.5	-0.9	-1.2	-1.3	1.6	1.6	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.7	0.2	-0.8	0.5	1.2	1.9	-0.8
Hair/balding pattern: Pattern 4	0.2	0.5	2.0	-0.4	-0.3	1.4	0.4	0.1	-0.5
Birth weight of first child	0.1	0.2	0.7	0.9	0.4	0.4	0.7	-0.0	-0.1
Peak expiratory flow (PEF)	1.0	2.3	4.6	-0.3	0.2	1.9	-2.1	-1.1	2.0
Pulse wave reflection index	0.3	0.4	1.0	-0.4	0.8	-0.2	-1.0	-0.1	-0.6
Ever highly irritable/argumentative for 2 days	1.2	1.4	5.2	2.3	0.9	-0.5	0.7	1.3	0.3
Loud music exposure frequency	0.5	0.5	1.3	0.2	1.1	0.8	-1.1	-0.2	0.0
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.7	-0.7	-0.9	-1.9	1.3	1.3	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.6	-0.8	-0.2	-0.1	-0.2	0.2	0.6
Blood clot in the leg (DVT)	0.5	0.7	1.8	-0.2	1.3	0.9	1.1	0.2	-0.5
Medication: Paracetamol	0.6	1.0	2.4	-0.0	-1.2	0.4	1.3	-0.0	-1.6
Headache pain in last month	0.3	0.5	0.9	-0.7	-0.3	-1.0	-0.9	0.9	0.2
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	6.4	2.4	1.7	1.0	-1.1	-0.3	2.5
Glaucoma (self-reported)	0.9	1.0	3.0	0.6	1.7	-0.2	0.3	0.4	1.6
Gout (self-reported)	0.2	0.2	1.0	-1.0	-0.4	0.3	0.2	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	4.2	-1.1	0.6	-2.0	1.3	0.8	0.5
Medication: Amlodipine	0.7	1.0	1.6	-0.8	-1.0	1.1	-0.1	-1.3	-1.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.5	-0.8	0.5	1.4	-0.9	-1.6	0.2
Birth weight	1.4	3.0	11.2	1.1	-1.3	-1.8	0.9	3.3	-0.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.3	0.7	-0.2	-0.7	-1.1	0.8	0.5
High blood pressure (siblings)	1.1	1.7	2.8	-1.0	-1.4	-1.3	1.0	1.2	-1.7
Forced vital capacity (FVC), Best measure	1.2	4.5	8.6	-1.1	-2.0	-2.4	2.2	1.6	-2.9
Body fat percentage	0.7	2.9	9.0	-0.9	0.4	1.1	-1.5	-3.0	1.9
Leg fat percentage (right)	0.8	3.0	6.8	-0.6	0.9	1.1	-1.4	-2.6	2.6
Arm fat-free mass (right)	0.8	4.2	8.8	-0.7	-1.0	-1.8	3.0	2.0	-2.7
Exposure to tobacco smoke outside home	1.1	1.4	2.9	1.0	0.2	1.0	-1.1	-1.7	1.6
Comparative body size at age 10	0.6	1.7	4.1	1.9	-0.9	-0.7	-0.3	0.9	2.0
Number of full brothers	0.4	0.6	2.6	0.2	-1.6	0.1	-0.8	-0.2	0.4
Worry too long after embarrassment	0.7	1.2	3.1	0.8	0.0	-1.2	1.3	-0.2	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	4.6	-1.2	-2.1	0.9	1.5	1.6	-2.0
Wheeze or whistling in the chest in last year	1.6	2.8	12.0	0.5	0.5	1.5	-3.5	-1.3	0.6
Number of children fathered	0.8	0.9	2.9	-0.1	-0.3	-0.2	1.5	1.7	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	4.2	4.9	6.5	-2.5	-2.2	-1.9	2.4	1.6	-2.5
Age at first live birth	0.2	0.4	0.9	-0.8	0.5	0.9	-0.2	0.6	-0.6
Pulse wave peak to peak time	0.8	0.9	2.1	0.1	-0.9	0.3	1.2	0.9	-1.4
Health satisfaction	0.5	0.6	2.6	0.8	0.2	0.7	0.1	1.6	0.4
Shortness of breath walking on level ground	0.2	0.3	1.1	0.3	0.2	1.0	0.5	0.4	-0.2
Qualifications: College or University degree	0.2	0.6	1.0	-1.0	1.0	0.3	-0.6	1.0	0.5
Eye problems/disorders: None of the above	0.8	1.0	1.7	-1.0	-1.3	-1.2	0.7	0.7	-1.0
Mouth/teeth dental problems: Loose teeth	1.7	2.0	7.2	-0.8	-0.6	-0.2	0.6	2.7	-1.8
Emphysema/chronic bronchitis	0.2	0.3	0.9	0.7	0.0	1.0	-0.0	0.1	-0.4
Medication for pain relief, constipation, heartburn	2.1	3.6	12.9	1.9	1.6	-1.1	-1.0	-0.0	3.6
Neck or shoulder pain in last month	0.6	0.8	2.5	-0.8	-0.6	0.1	1.1	0.2	-1.6
Medication: Blood pressure	0.9	1.6	3.3	-1.8	-1.6	0.0	-0.1	-0.5	-1.8
Angina (self-reported)	0.3	0.4	2.0	0.2	0.2	0.3	-0.5	-0.2	-1.4
Migraine (self-reported)	0.4	0.5	0.9	-0.9	-0.6	-0.6	0.4	-0.5	-0.9
Medication: Ibuprofen	1.6	2.0	5.9	-1.2	-2.4	-0.3	1.0	1.3	-1.3
Medication: Allopurinol	0.2	0.3	1.0	0.7	0.5	0.3	-0.2	-0.2	1.0
Medication: Omeprazole	1.5	1.7	5.7	-0.7	0.0	1.8	-0.9	-2.4	-0.6
Medication: Seretide 50 evohaler	0.3	0.3	0.8	-0.8	0.2	0.9	0.4	-0.2	-0.6
Mean time to correctly identify matches	1.3	2.5	8.9	3.0	0.3	-1.3	0.9	1.9	0.5
Heart disease (mother)	1.3	1.5	5.0	0.2	1.0	2.2	-1.4	-0.8	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.9	0.3	0.5	0.1	-0.4	-0.8
Whole body fat mass	0.2	1.0	3.7	-0.8	0.1	0.7	-0.6	-1.9	0.8
Leg fat mass (right)	0.3	1.0	2.6	-0.8	0.1	0.6	-0.7	-1.6	1.3
Arm predicted mass (right)	0.7	3.3	7.2	-0.3	-0.8	-1.5	2.7	1.8	-2.6
Pulse rate, automated reading	0.1	0.3	1.1	0.0	0.2	0.0	-0.8	0.1	1.1
Alcohol intake frequency.	0.3	0.7	1.4	1.0	0.8	-0.6	-0.5	-1.2	0.9
Comparative height size at age 10	0.9	4.9	13.6	-1.5	-2.5	-1.2	1.9	1.4	-3.7
Number of full sisters	1.8	2.3	7.1	1.1	1.2	-2.7	-0.7	1.4	1.2
Suffer from ‘nerves’	1.8	2.8	5.7	-0.6	-1.4	-2.3	2.4	1.6	-1.0
Overall health rating	0.3	0.6	2.0	-0.5	-1.4	-0.9	-0.0	-0.0	-0.8
Chest pain or discomfort	0.4	0.5	2.0	-1.4	-0.5	-0.4	-0.3	0.6	-0.6
Had major operations	0.6	0.7	2.4	0.3	0.0	-1.1	-0.0	1.5	0.8
Age at last live birth	0.5	0.7	2.3	-0.9	0.3	0.3	0.1	1.1	-1.5
Family relationship satisfaction	2.0	2.4	4.8	0.7	2.2	2.1	-1.9	-1.1	0.5
Leg pain on walking	0.1	0.2	0.4	-0.4	-0.1	0.7	0.1	0.1	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.0	0.5	0.2	0.6	-0.5	-0.7	1.4
Commuting to job workplace: Car/motor vehicle	3.0	3.4	8.0	-1.7	-2.7	0.8	0.2	-1.3	-2.8
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	3.6	1.9	0.5	-0.2	-1.2	-1.3	1.3
Medication: Aspirin	5.2	6.9	22.1	-2.9	-1.5	-1.5	1.9	1.5	-4.7
Supplements: Vitamin C	1.1	1.4	4.0	-0.2	-0.7	-1.1	2.0	1.3	-0.7
Knee pain experienced in last month	0.3	0.4	1.4	0.7	1.2	-0.6	0.5	0.0	-0.2
Hypertension (Self-reported)	0.8	2.2	6.0	-2.3	-0.4	-0.5	-0.0	-1.1	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	0.1	0.6	0.9	-0.9	-0.9	0.5
Illnesses of father: Heart disease	0.5	0.7	2.2	1.1	1.5	0.5	0.0	0.6	-0.1
Illnesses of siblings: Diabetes	0.2	0.3	0.8	0.3	-0.6	-0.9	-0.1	0.4	0.4
Smoking status: Previous	0.6	0.8	2.6	0.8	-0.8	0.6	-0.5	-0.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.9	-0.7	-1.3	-0.7	1.2	0.2	-2.2
Whole body fat-free mass	0.8	4.4	8.8	-0.1	-1.0	-1.5	3.0	2.4	-2.9
Leg fat-free mass (right)	0.5	2.6	5.2	-0.5	-1.1	-1.0	2.3	1.8	-2.2
Arm fat percentage (left)	0.9	3.4	7.9	-0.6	0.2	1.2	-2.1	-2.8	2.6
Average weekly red wine intake	1.3	2.0	9.3	0.3	0.1	-1.4	0.4	3.1	-0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.8	0.5	-0.9	0.3	0.6	-1.0
Mood swings	0.4	0.8	1.9	1.2	-0.8	-0.6	-0.5	-0.0	1.4
Loneliness, isolation	0.7	1.0	3.3	0.1	-1.2	0.9	-0.8	-0.4	1.8
Long-standing illness, disability or infirmity	0.3	0.5	1.4	1.2	-0.9	0.2	0.7	0.3	0.4
Ever had bowel cancer screening	1.0	1.1	2.8	1.6	1.7	0.3	-0.3	-0.4	1.0
Diabetes diagnosed by doctor	1.1	1.7	8.4	-2.9	-0.7	-0.4	-0.2	-1.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.8	1.1	0.9	0.8	-1.9	0.7	2.0
Friendships satisfaction	0.5	0.6	2.2	0.7	0.5	-0.6	0.2	1.5	-0.5
Qualifications: nursing, teaching	0.4	0.5	2.0	0.1	1.4	0.5	0.3	0.1	1.0
Commuting to job workplace: Walk	0.4	0.5	1.1	0.3	0.2	-1.0	-0.2	1.0	0.8
Eye problems/disorders: Cataract	0.6	0.7	1.5	0.6	1.2	1.2	0.4	0.2	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.6	1.3	0.3	0.6	-0.0	0.4	0.4
Medication for cholesterol	0.2	0.3	1.0	0.5	-0.1	0.7	-0.1	0.5	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.6	0.5	0.2	0.0	-0.7	0.1
Back pain experienced in last month	0.9	1.3	3.6	1.9	0.5	-0.0	0.6	1.4	1.3
Mineral and other dietary supplements	0.6	0.9	2.5	-1.6	-0.3	-0.0	1.2	-0.5	-0.9
Breast cancer (self-reported)	0.7	0.9	2.6	-0.8	-1.6	-0.2	0.3	-1.3	-0.3
Asthma (self-reported)	2.1	4.1	13.4	0.5	1.8	1.7	-3.7	-2.1	0.6
Osteoporosis (self-reported)	3.0	3.7	7.6	-1.7	-1.0	-2.0	2.5	2.8	-0.7
Osteoarthritis (self-reported)	1.2	1.5	4.0	2.0	0.5	-1.2	0.8	0.1	1.7
Medication: Aspirin	4.8	6.2	18.9	-2.9	-1.5	-1.6	2.0	1.2	-4.3
Medication: Gliclazide	1.4	1.6	2.8	-1.7	-1.0	0.4	-1.6	-1.7	0.3
Illnesses of father: None of the above (group 1)	0.7	0.8	1.9	1.2	0.5	-1.0	0.2	0.7	1.4
Smoking status: Current	0.6	1.0	3.8	0.6	-0.1	2.0	-0.5	-0.7	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	4.6	-0.5	-1.0	-2.1	0.7	1.3	1.4
Whole body water mass	0.8	4.4	8.9	-0.1	-0.8	-1.6	3.0	2.5	-2.8
Leg predicted mass (right)	0.5	2.5	5.1	-0.4	-1.0	-0.9	2.3	1.8	-2.2
Arm fat mass (left)	0.3	1.1	2.9	-0.8	-0.2	0.2	-1.0	-1.7	1.4
Number of self-reported non-cancer illnesses	0.2	0.4	1.1	-1.1	-0.0	0.2	-0.4	-0.7	-0.7
Average weekly champagne plus white wine intake	0.9	1.3	4.0	-1.6	0.0	-0.3	0.3	1.0	-2.0
Miserableness	1.0	1.7	5.1	0.4	-2.3	-1.2	1.6	0.7	-0.4
Guilty feelings	1.0	1.6	3.7	-0.2	-0.2	-1.7	1.3	1.9	1.0
Wears glasses or contact lenses	0.3	0.4	1.1	0.1	0.9	0.2	0.6	0.3	-1.1
Ever taken oral contraceptive pill	0.6	0.7	2.9	-0.4	-1.7	-0.5	-0.4	0.9	-0.1
Hearing aid user	1.6	1.8	6.3	2.5	1.7	1.0	-0.5	-0.3	0.2
Mother’s age at death	0.7	0.8	3.5	-0.7	0.6	-0.6	-0.6	-0.0	1.9
Financial situation satisfaction	0.8	0.9	4.0	-0.2	0.4	2.0	-0.9	0.8	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	0.3	-0.6	-0.9	-0.2	0.1	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.0	0.6	0.1	0.2	0.4	0.4
Eye problems/disorders: Glaucoma	1.5	1.7	4.7	0.7	2.2	0.2	-1.0	-0.2	2.0
Medication: Blood pressure	0.3	0.5	1.9	0.3	-0.3	-0.1	0.1	-0.9	-1.4
Pain type(s) experienced in last month: Hip pain	1.8	2.2	5.0	2.2	1.5	1.2	-1.1	-1.1	1.4
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.3	2.1	0.9	1.1	-2.0	-0.2	0.9
High cholesterol (Self-reported)	0.1	0.2	0.9	0.2	0.4	-0.9	0.3	-0.3	-0.3
Medication: Bendroflumethiazide	0.3	0.5	1.6	-0.2	0.6	0.4	0.0	-0.7	-1.3
Medication: Paracetamol	0.6	0.9	2.2	0.0	-0.5	0.1	1.5	1.0	-1.4
Medication: Lisinopril	1.1	1.4	4.4	2.1	1.3	0.5	-1.3	0.1	0.6
Medication: Atorvastatin	1.6	1.9	4.2	-0.3	0.9	-2.0	1.5	2.0	0.5
Illnesses of father: High blood pressure	0.6	0.8	2.5	-1.6	-0.5	0.7	-0.6	0.4	-0.9
Alcohol drinker status: Never	0.3	0.3	1.0	-0.2	0.2	-0.1	0.3	-1.0	-0.9
Ever smoked	1.3	2.3	3.9	1.4	-1.0	1.9	-1.8	-2.0	0.3
Basal metabolic rate	0.5	3.0	6.0	-0.2	-0.9	-1.4	2.5	1.9	-2.4
Leg fat percentage (left)	0.9	3.2	8.4	-0.7	0.9	1.0	-1.4	-2.6	2.9
Arm fat-free mass (left)	0.7	3.8	8.0	-0.4	-0.8	-1.5	2.8	2.2	-2.6
Number of operations (self-reported)	2.8	4.2	9.1	1.6	1.8	2.0	-3.0	-1.1	2.2
Average weekly beer plus cider intake	0.8	1.2	2.6	-0.6	-1.6	-1.5	1.1	0.7	-0.6
Irritability	0.3	0.5	1.9	0.3	-1.4	-0.2	0.5	0.6	-0.2
Risk taking	0.8	1.2	3.8	-1.3	-0.0	1.9	0.0	0.6	-1.3
Ever had prostate specific antigen (PSA) test	0.8	1.0	3.2	0.9	1.0	0.2	-0.3	1.8	0.8
Fractured/broken bones in last 5 years	0.5	0.6	2.8	0.4	-0.1	1.7	-0.6	-0.7	0.1
Age started oral contraceptive pill	0.9	1.2	1.7	-1.0	-1.3	0.2	1.2	1.2	-1.1
Diastolic blood pressure, automated reading	1.0	3.0	6.6	0.0	-0.3	-1.4	2.4	2.6	-2.0
Ever depressed for a whole week	0.2	0.3	1.1	0.3	0.1	0.5	-0.3	-0.0	1.0
Unable to work because of sickness or disability	0.7	0.9	3.3	1.8	-0.1	0.9	-1.2	-0.1	0.1
Commuting to job workplace: Cycle	0.5	0.6	1.9	0.3	-0.5	-0.5	0.4	1.4	1.0
Myopia	0.7	1.1	2.2	0.5	-0.3	-1.5	1.5	1.0	-0.7
Vascular/heart problems diagnosed by doctor	1.0	2.8	8.8	2.4	0.4	-0.1	0.2	1.5	3.0
Cholesterol lowering medication	0.5	0.7	2.0	-0.5	0.9	0.5	-0.6	-1.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	6.1	-1.0	-0.5	2.1	-1.5	-2.5	-0.3
Pain experienced in last month	0.2	0.3	1.9	-1.4	-0.0	-0.2	0.0	0.2	-0.2
Supplements: Calcium	0.6	0.7	1.4	1.1	-1.0	-1.2	0.1	0.6	0.4
Basal cell carcinoma (self-reported)	0.6	0.7	1.7	-0.3	-1.2	0.7	-1.3	0.7	0.4
Heart attack/myocardial infarction (self-reported)	3.0	3.9	9.6	-2.1	-2.1	-1.5	1.4	0.5	-3.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	-0.2	1.0	0.9	1.3	0.2	-0.5
Heart disease (siblings)	0.3	0.3	1.2	0.8	0.1	-0.0	-0.3	-1.1	0.4
Alcohol drinker status: Previous	0.3	0.3	0.9	0.0	0.3	-1.0	0.2	-0.8	-0.0
Pack years of smoking	1.7	2.6	5.6	0.3	1.2	1.9	-2.4	-1.8	1.2
Impedance of whole body	0.3	1.5	4.7	-1.3	-0.4	-0.3	-1.3	-2.2	-0.7
Leg fat mass (left)	0.3	1.0	2.4	-0.8	0.0	0.6	-0.7	-1.5	1.5
Arm predicted mass (left)	0.7	3.4	7.6	-0.5	-0.7	-1.5	2.8	2.0	-2.4