Best TWAS P=2.12e-14 · Best GWAS P=4.83e-35 conditioned to 5.23e-24
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MARCH5 | 0.09 | 0.07 | blup | 335 | 0.08 | 9.5e-10 | 6.8 | -7.6 | 2.1e-14 | 0.20 | 0.01 | 0.98 | TRUE |
| 2 | GTEx | Artery Tibial | MARCH5 | 0.05 | 0.02 | lasso | 3 | 0.01 | 5.6e-02 | -4.6 | 7.0 | 2.9e-12 | -0.07 | 0.09 | 0.68 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | MARCH5 | 0.15 | 0.03 | enet | 20 | 0.08 | 1.7e-03 | 4.8 | 5.8 | 8.2e-09 | -0.19 | 0.12 | 0.08 | FALSE |
| 4 | GTEx | Esophagus Mucosa | MARCH5 | 0.05 | 0.02 | lasso | 8 | 0.02 | 1.6e-02 | 4.8 | 5.6 | 2.5e-08 | -0.12 | 0.04 | 0.78 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | MARCH5 | 0.06 | 0.04 | lasso | 6 | 0.06 | 1.1e-05 | 6.9 | 6.5 | 6.1e-11 | -0.10 | 0.02 | 0.98 | FALSE |
| 6 | YFS | Blood | MARCH5 | 0.05 | 0.06 | enet | 20 | 0.08 | 2.0e-25 | 6.7 | -5.6 | 2.5e-08 | 0.18 | 0.03 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CYP26A1 | 0.07 | 0.02 | enet | 7 | 0.03 | 2.8e-04 | -8.2 | 6.4 | 1.4e-10 | -0.33 | 0.04 | 0.10 | TRUE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | MARCH5 | 0.07 | 0.08 | enet | 15 | 0.09 | 7.4e-09 | -5.0 | 6.5 | 6.1e-11 | -0.12 | 0.03 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | MARCH5 | 0.31 | 0.23 | lasso | 10 | 0.21 | 2.0e-06 | 6.8 | 6.9 | 4.3e-12 | -0.15 | 0.01 | 0.99 | FALSE |