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chr10:95,606,207-99,876,121

Best TWAS P=7.87e-28 · Best GWAS P=2.96e-21 conditioned to 7.75e-11

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
41	GTEx	Testis	TCTN3	0.11	0.02	enet	22	0.01	1.2e-01	-7.4	10.9	7.9e-28	0.27	0.11	0.19	TRUE
29	GTEx	Nerve Tibial	HELLS	0.12	0.12	enet	17	0.10	1.6e-07	-5.5	-6.2	5.1e-10	0.02	0.11	0.89	TRUE
48	METSIM	Adipose	RRP12	0.13	0.09	lasso	8	0.10	3.6e-14	6.0	6.1	8.1e-10	0.07	0.02	0.98	TRUE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	TCTN3	0.09	0.10	enet	4	0.11	1.8e-12	-7.4	7.6	3.2e-14	-0.04	0.00	1.00	FALSE
87	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ENTPD1	0.25	0.21	lasso	7	0.31	1.4e-11	-5.8	7.4	1.2e-13	-0.04	0.02	0.98	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	RP11-429G19.3	0.35	0.14	lasso	14	0.13	5.9e-05	-7.4	7.3	2.8e-13	-0.03	0.02	0.98	FALSE
34	GTEx	Prostate	CCNJ	0.23	0.18	lasso	2	0.03	7.1e-02	-7.4	7.3	3.1e-13	-0.04	0.02	0.90	FALSE
64	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ENTPD1	0.13	0.15	enet	18	0.21	9.1e-23	-7.3	7.2	5.6e-13	-0.05	0.01	0.99	FALSE
24	GTEx	Liver	ALDH18A1	0.21	0.16	enet	17	0.16	3.4e-05	5.6	7.1	9.5e-13	-0.03	0.75	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ENTPD1	0.07	0.04	enet	10	0.06	1.7e-07	-5.8	7.1	1.5e-12	-0.04	1.00	0.00	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	ENTPD1	0.41	0.41	enet	29	0.44	1.0e-15	6.4	7.0	1.9e-12	-0.04	1.00	0.00	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	ENTPD1-AS1	0.32	0.23	enet	30	0.27	2.5e-09	-7.4	7.0	2.3e-12	-0.03	1.00	0.00	FALSE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ENTPD1	0.07	0.07	enet	16	0.10	4.8e-11	-6.0	6.9	3.8e-12	-0.03	0.03	0.97	FALSE
5	GTEx	Artery Aorta	TCTN3	0.09	0.07	enet	17	0.03	8.4e-03	6.4	6.9	4.7e-12	-0.04	0.65	0.02	FALSE
30	GTEx	Nerve Tibial	TCTN3	0.11	0.05	lasso	4	0.04	1.2e-03	-7.4	6.9	5.3e-12	-0.01	0.72	0.01	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	ENTPD1	0.03	0.01	blup	91	0.01	1.1e-02	-4.6	6.7	1.6e-11	-0.08	0.05	0.72	FALSE
20	GTEx	Heart Atrial Appendage	TCTN3	0.12	0.04	enet	17	0.03	1.8e-02	6.7	6.7	2.2e-11	-0.05	0.77	0.02	FALSE
18	GTEx	Esophagus Muscularis	TCTN3	0.31	0.17	lasso	10	0.21	9.8e-13	-7.3	6.6	5.4e-11	-0.01	1.00	0.00	FALSE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	ENTPD1	0.07	0.07	blup	90	0.11	2.1e-12	6.4	6.5	8.7e-11	-0.05	0.03	0.97	FALSE
59	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ENTPD1	0.13	0.05	blup	91	0.10	1.6e-05	-7.4	6.5	9.3e-11	-0.01	0.02	0.97	FALSE
61	The Cancer Genome Atlas	Colon Adenocarcinoma	ENTPD1	0.06	0.10	lasso	7	0.10	3.9e-06	6.5	6.5	1.0e-10	-0.03	0.06	0.92	FALSE
16	GTEx	Cells Transformed fibroblasts	TCTN3	0.09	0.06	lasso	6	0.03	1.3e-03	6.4	6.5	1.1e-10	-0.04	0.85	0.01	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ENTPD1	0.08	0.05	blup	90	0.07	1.0e-06	5.7	6.4	1.2e-10	-0.06	0.40	0.59	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	ENTPD1	0.05	0.03	enet	17	0.04	1.9e-05	-6.0	6.3	2.8e-10	-0.05	0.29	0.57	FALSE
63	The Cancer Genome Atlas	Glioblastoma Multiforme	TCTN3	0.20	0.07	lasso	2	0.09	1.4e-03	6.5	6.3	2.9e-10	-0.04	0.01	0.59	FALSE
53	YFS	Blood	ENTPD1	0.18	0.10	enet	47	0.21	3.2e-67	-7.4	6.3	3.3e-10	-0.01	1.00	0.00	FALSE
86	The Cancer Genome Atlas	Stomach Adenocarcinoma	ENTPD1	0.07	0.03	blup	91	0.04	4.5e-04	5.8	6.2	7.7e-10	-0.01	0.18	0.56	FALSE
36	GTEx	Skin Sun Exposed Lower leg	RRP12	0.22	0.14	lasso	6	0.13	1.1e-10	6.0	6.1	1.1e-09	0.05	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TBC1D12	0.04	0.01	blup	63	0.03	8.3e-03	-6.1	6.1	1.1e-09	-0.01	0.02	0.74	FALSE
54	YFS	Blood	RRP12	0.28	0.46	lasso	2	0.46	1.1e-173	6.0	6.1	1.4e-09	0.06	0.02	0.98	FALSE
42	GTEx	Whole Blood	RRP12	0.17	0.14	lasso	5	0.16	1.1e-14	6.0	6.0	1.6e-09	0.06	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RRP12	0.05	0.05	lasso	6	0.05	1.6e-06	5.6	6.0	1.6e-09	0.06	0.02	0.98	FALSE
50	NTR	Blood	RRP12	0.14	0.22	lasso	5	0.21	2.7e-67	5.9	6.0	1.9e-09	0.05	0.02	0.98	FALSE
40	GTEx	Spleen	ENTPD1	0.31	0.13	enet	22	0.19	1.3e-05	-7.3	6.0	2.0e-09	0.02	0.55	0.04	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	TBC1D12	0.04	0.04	blup	63	0.03	3.9e-04	-5.4	-6.0	2.1e-09	0.04	0.08	0.83	FALSE
7	GTEx	Brain Caudate basal ganglia	RRP12	0.23	0.13	lasso	2	0.08	3.3e-03	6.0	6.0	2.3e-09	0.05	0.02	0.93	FALSE
26	GTEx	Muscle Skeletal	RRP12	0.26	0.27	lasso	4	0.27	1.5e-26	5.9	6.0	2.3e-09	0.05	0.02	0.98	FALSE
19	GTEx	Heart Atrial Appendage	RRP12	0.26	0.24	enet	14	0.26	5.0e-12	5.9	6.0	2.4e-09	0.05	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Colon Adenocarcinoma	RRP12	0.09	0.08	lasso	1	0.07	6.3e-05	6.0	6.0	2.5e-09	0.05	0.02	0.98	FALSE
46	METSIM	Adipose	FRAT2	0.04	0.06	lasso	6	0.04	3.8e-07	6.0	6.0	2.6e-09	0.05	0.02	0.98	FALSE
25	GTEx	Lung	RRP12	0.13	0.17	lasso	6	0.16	4.7e-12	5.9	6.0	2.7e-09	0.05	0.02	0.98	FALSE
21	GTEx	Heart Atrial Appendage	RP11-452K12.7	0.26	0.17	lasso	9	0.21	1.2e-09	5.8	5.9	2.8e-09	0.06	0.02	0.98	FALSE
80	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RRP12	0.14	0.15	lasso	1	0.12	1.6e-05	5.9	5.9	2.8e-09	0.04	0.02	0.98	FALSE
22	GTEx	Heart Left Ventricle	RRP12	0.31	0.19	enet	15	0.20	5.1e-11	5.8	5.9	3.0e-09	0.04	0.02	0.98	FALSE
10	GTEx	Brain Frontal Cortex BA9	HELLS	0.16	0.09	enet	20	0.15	1.0e-04	-5.8	-5.9	3.4e-09	0.02	0.03	0.95	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RRP12	0.02	0.03	lasso	5	0.02	2.0e-03	5.9	5.9	3.4e-09	0.04	0.02	0.88	FALSE
43	GTEx	Whole Blood	RP11-452K12.7	0.19	0.15	lasso	4	0.16	3.7e-14	6.0	5.9	3.6e-09	0.04	0.02	0.98	FALSE
45	METSIM	Adipose	FRAT1	0.06	0.03	lasso	10	0.03	2.2e-05	5.6	5.9	4.1e-09	0.07	0.03	0.97	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HELLS	0.03	0.03	blup	47	0.03	1.7e-04	-5.8	-5.9	4.4e-09	0.03	0.02	0.97	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	RRP12	0.02	0.01	blup	57	0.01	7.0e-02	5.8	5.9	4.7e-09	0.05	0.02	0.86	FALSE
44	METSIM	Adipose	ALDH18A1	0.04	0.05	enet	20	0.03	5.1e-05	-3.6	5.8	5.5e-09	-0.09	0.99	0.00	FALSE
78	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ENTPD1	0.08	0.01	enet	13	0.05	2.0e-04	-6.0	5.8	5.5e-09	-0.06	0.02	0.92	FALSE
17	GTEx	Esophagus Mucosa	RP11-429G19.3	0.10	0.00	enet	12	0.02	3.2e-02	-5.8	5.8	5.6e-09	-0.02	0.08	0.81	FALSE
79	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RRP12	0.07	0.04	lasso	4	0.02	4.9e-02	5.8	5.8	5.8e-09	0.04	0.01	0.76	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	RRP12	0.03	0.05	lasso	1	0.04	8.8e-05	5.8	5.8	5.9e-09	0.04	0.02	0.98	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	HELLS	0.05	0.02	blup	47	0.03	9.6e-04	-5.8	-5.8	6.5e-09	0.04	0.02	0.95	FALSE
8	GTEx	Brain Cerebellar Hemisphere	RRP12	0.27	0.24	lasso	7	0.18	2.7e-05	5.8	5.8	6.7e-09	0.05	0.02	0.96	FALSE
3	GTEx	Adipose Subcutaneous	RRP12	0.09	0.06	lasso	3	0.05	1.4e-04	5.8	5.8	6.8e-09	0.04	0.02	0.98	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	RRP12	0.12	0.14	lasso	7	0.14	3.7e-18	6.0	5.8	7.2e-09	0.06	0.02	0.98	FALSE
27	GTEx	Muscle Skeletal	RP11-452K12.7	0.16	0.14	lasso	5	0.13	1.4e-12	5.9	5.8	7.5e-09	0.04	0.02	0.98	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	RRP12	0.32	0.26	lasso	6	0.23	6.5e-07	5.9	5.8	7.8e-09	0.04	0.02	0.98	FALSE
4	GTEx	Artery Aorta	RRP12	0.16	0.11	lasso	6	0.09	9.1e-06	5.6	5.8	8.2e-09	0.06	0.02	0.97	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	HELLS	0.03	0.03	lasso	3	0.02	5.7e-03	-6.1	-5.8	9.0e-09	0.00	0.01	0.97	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	TCTN3	0.05	0.02	enet	5	0.02	1.5e-03	6.5	5.7	9.5e-09	0.00	0.03	0.86	FALSE
33	GTEx	Pancreas	RRP12	0.22	0.21	enet	25	0.24	2.7e-10	5.9	5.7	9.9e-09	0.04	0.02	0.98	FALSE
9	GTEx	Brain Cerebellum	HELLS	0.26	0.20	lasso	9	0.19	2.8e-06	-6.0	-5.7	1.0e-08	0.01	0.03	0.97	FALSE
75	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RRP12	0.09	0.05	blup	57	0.05	1.6e-03	6.0	5.7	1.0e-08	0.07	0.02	0.94	FALSE
12	GTEx	Breast Mammary Tissue (Female)	RRP12	0.24	0.07	lasso	5	0.02	1.1e-01	5.6	5.7	1.1e-08	0.06	0.02	0.81	FALSE
51	NTR	Blood	TCTN3	0.02	0.00	bslmm	515	0.01	1.5e-03	-7.3	5.7	1.3e-08	-0.06	0.29	0.02	FALSE
70	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RRP12	0.14	0.07	lasso	4	0.10	3.3e-06	6.0	5.7	1.3e-08	0.06	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TCTN3	0.04	0.04	lasso	2	0.04	4.2e-05	5.8	5.7	1.4e-08	-0.02	0.16	0.42	FALSE
31	GTEx	Nerve Tibial	LCOR	0.12	0.06	lasso	1	0.03	3.0e-03	5.7	5.7	1.5e-08	0.07	0.06	0.60	FALSE
39	GTEx	Skin Sun Exposed Lower leg	RP11-429G19.3	0.21	0.17	enet	20	0.20	5.0e-16	-5.8	5.7	1.6e-08	-0.06	1.00	0.00	FALSE
23	GTEx	Heart Left Ventricle	TCTN3	0.09	0.01	lasso	7	0.02	2.7e-02	-5.1	5.6	1.9e-08	0.02	0.22	0.04	FALSE
38	GTEx	Skin Sun Exposed Lower leg	ENTPD1	0.08	0.11	lasso	3	0.11	2.0e-09	-5.8	5.6	1.9e-08	-0.04	1.00	0.00	FALSE
49	NTR	Blood	FRAT2	0.06	0.07	bslmm	466	0.07	3.1e-20	6.0	5.6	2.0e-08	0.04	0.02	0.98	FALSE
47	METSIM	Adipose	HELLS	0.03	0.04	lasso	3	0.03	9.3e-05	-5.5	-5.5	3.7e-08	0.04	0.06	0.94	FALSE
32	GTEx	Ovary	HELLS	0.15	0.04	lasso	5	0.09	3.1e-03	-5.4	-5.5	4.0e-08	0.02	0.05	0.73	FALSE
28	GTEx	Muscle Skeletal	RP11-429G19.3	0.06	0.02	lasso	2	0.00	1.8e-01	5.8	5.5	4.1e-08	-0.03	0.19	0.15	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	RP11-429G19.3	0.22	0.22	lasso	4	0.22	1.4e-12	-4.5	5.4	6.9e-08	-0.04	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	RRP12	0.07	0.05	enet	19	0.05	8.6e-11	5.7	5.3	1.1e-07	0.07	0.03	0.97	FALSE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FRAT2	0.05	0.01	blup	39	0.02	1.1e-02	6.0	5.3	1.2e-07	0.03	0.01	0.70	FALSE
6	GTEx	Artery Tibial	ALDH18A1	0.15	0.08	enet	17	0.09	1.1e-07	5.6	5.3	1.4e-07	-0.02	0.99	0.00	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	HELLS	0.04	0.01	blup	47	0.03	1.3e-06	-5.4	-5.2	2.0e-07	0.05	0.04	0.95	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	HELLS	0.03	0.02	blup	47	0.03	2.1e-04	-6.1	-5.2	2.1e-07	0.04	0.02	0.95	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ENTPD1	0.13	0.09	lasso	6	0.08	1.4e-09	5.8	5.2	2.3e-07	-0.03	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TCTN3	0.04	0.01	lasso	7	0.03	2.4e-04	2.1	5.1	3.0e-07	0.02	0.45	0.02	FALSE
37	GTEx	Skin Sun Exposed Lower leg	HELLS	0.05	0.02	lasso	3	0.00	1.2e-01	-6.1	-5.1	3.0e-07	0.00	0.02	0.96	FALSE