Hub : Genes

MARCH5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0850 0.0290 1.7e-08 0.068 0.078 0.061 0.075 0.059 1.0e-08 9.5e-10 6.9e-08 1.8e-09 1.1e-07
2 GTEx Artery Aorta 0.1240 0.0580 5.7e-03 0.025 NA 0.073 NA 0.085 1.6e-02 NA 7.8e-05 NA 1.9e-05
3 GTEx Artery Tibial 0.0489 0.0242 3.2e-03 0.016 NA 0.006 NA 0.009 1.9e-02 NA 9.9e-02 NA 5.6e-02
4 GTEx Breast Mammary Tissue (Male) 0.0309 0.0493 2.9e-01 -0.012 NA 0.028 NA -0.007 7.5e-01 NA 7.5e-02 NA 5.0e-01
5 GTEx Breast Mammary Tissue (Female) 0.1522 0.0779 1.8e-02 0.032 NA 0.084 NA 0.044 4.0e-02 NA 1.7e-03 NA 1.9e-02
6 GTEx Colon Transverse 0.1120 0.0430 9.1e-05 0.122 NA 0.075 NA 0.036 2.1e-06 NA 1.9e-04 NA 7.9e-03
7 GTEx Esophagus Mucosa 0.0550 0.0280 7.2e-03 0.016 NA 0.020 NA 0.020 2.8e-02 NA 1.7e-02 NA 1.6e-02
8 GTEx Liver 0.1950 0.0830 1.4e-03 0.135 NA 0.102 NA 0.114 1.4e-04 NA 8.9e-04 NA 4.4e-04
9 GTEx Nerve Tibial 0.0643 0.0284 7.1e-04 0.051 NA 0.045 NA 0.052 1.7e-04 NA 3.8e-04 NA 1.3e-04
10 GTEx Skin Not Sun Exposed Suprapubic 0.1020 0.0370 6.0e-05 0.087 NA 0.078 NA 0.097 1.7e-05 NA 4.3e-05 NA 5.4e-06
11 GTEx Skin Sun Exposed Lower leg 0.0550 0.0220 1.1e-04 0.040 NA 0.054 NA 0.059 3.0e-04 NA 2.7e-05 NA 1.1e-05
12 GTEx Thyroid 0.1170 0.0390 5.7e-06 0.033 NA 0.058 NA 0.066 1.4e-03 NA 2.9e-05 NA 9.2e-06
13 YFS Blood 0.0530 0.0153 0.0e+00 0.063 0.079 0.082 0.080 0.081 8.2e-20 1.5e-24 2.0e-25 9.6e-25 3.3e-25
14 TCGA Thyroid Carcinoma 0.0670 0.0310 4.5e-09 0.085 0.075 0.087 NA 0.042 1.3e-08 7.9e-08 7.4e-09 NA 5.3e-05
15 TCGA Uterine Corpus Endometrial Carcinoma 0.3120 0.1070 5.1e-07 0.233 0.199 0.199 NA 0.206 3.7e-07 3.1e-06 3.1e-06 NA 2.0e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bipolar Disorder (2018) 0.1 0.1 0.4 0.5 0.2 -0.2 0.0 0.5 0.0 0.1 0.3 0.6 0.3 -0.2 0.5 0.5 -0.3 -0.6
Bipolar Disorder or Schizophrenia 0.2 0.6 1.9 1.1 -0.9 -0.6 0.0 0.6 -0.1 -0.4 -0.7 -0.1 -0.4 -1.0 0.6 1.1 -0.8 -1.4
Depressed Affect (Nagel 2018) 0.4 0.8 3.5 -0.0 -0.7 -0.7 0.0 0.0 -1.9 -1.3 -0.4 -1.1 -1.0 -0.7 -1.2 0.2 -1.1 -0.6
Depression (Nagel 2018) 0.4 0.6 2.0 0.7 -1.4 -0.9 0.0 -0.3 -0.9 -1.2 0.1 -0.3 -0.1 -0.7 0.2 0.6 -1.0 -0.9
Intelligence (Savage-Jansen 2018) 3.8 11.6 24.2 -3.0 0.7 3.6 0.0 1.1 4.6 4.3 2.0 3.8 3.5 4.1 3.3 -3.0 4.9 4.4
Neuroticism (Nagel 2018) 1.9 4.6 8.5 2.4 -2.0 -2.1 0.0 -1.1 -2.6 -2.9 -1.4 -2.0 -1.9 -2.6 -1.2 2.0 -2.9 -2.7
Schizophrenia (2018) 0.3 0.7 1.6 1.1 -1.3 -0.6 0.0 0.4 -0.2 -0.6 -1.1 -0.7 -0.8 -1.1 0.4 1.0 -0.8 -1.3
Schizophrenia vs Biploar Disorder 0.8 1.1 4.8 -0.4 -0.4 1.4 0.0 0.1 2.2 0.6 1.1 1.0 1.2 0.2 1.5 1.3 1.0 0.3
Worry (Nagel 2018) 2.4 5.0 10.2 3.0 -2.5 -2.2 0.0 -1.3 -1.9 -2.9 -1.5 -1.7 -1.7 -3.0 -0.3 2.4 -2.9 -3.2
Alzheimer’s Disease (in mother) 0.6 0.7 3.4 1.3 -1.2 0.3 0.0 0.1 1.9 0.8 -0.5 0.5 0.3 -0.5 1.2 0.3 0.7 -0.0
Alzheimer’s Disease (in father) 1.4 1.6 4.2 -2.0 1.6 0.8 0.0 1.2 0.8 1.2 0.9 0.7 1.2 1.8 0.9 -1.4 1.3 1.6
Alzheimer’s Disease (including proxy) 1.4 2.0 9.5 -0.6 0.5 1.2 0.0 0.9 3.1 2.2 0.5 1.0 1.4 1.1 1.7 -0.6 2.0 1.0
Crohns Disease (2017) 0.9 1.9 10.2 3.2 -1.1 -0.8 0.0 -2.9 0.0 -1.2 -0.8 -0.9 -1.5 -1.4 0.5 0.8 -0.3 -0.9
Irritable Bowel Disease (IBD) 3.0 7.1 22.2 4.7 -1.7 -2.5 0.0 -4.1 -1.8 -2.6 -2.7 -3.1 -3.6 -3.0 -0.9 0.9 -1.9 -2.2
Ulcerative Colitis (UC) 3.5 6.6 13.4 3.7 -0.9 -2.7 0.0 -3.0 -2.6 -3.0 -2.9 -3.2 -3.5 -2.8 -1.4 0.8 -2.3 -2.3
Major Depression (MDD) 2.0 2.4 7.4 0.8 -0.0 -2.1 0.0 -0.9 -2.4 -2.7 -1.7 -1.1 -0.9 -1.2 -1.6 1.3 -2.0 -1.5
Reaction Time 1.7 3.3 14.7 -0.8 -0.9 1.1 0.0 1.6 3.8 0.5 1.3 2.4 2.4 0.8 2.1 1.1 2.6 1.4
Verbal and Numeric Reasoning (VNR) 3.9 9.3 16.7 -2.7 -0.2 3.9 0.0 1.0 4.0 3.7 2.2 3.3 3.3 3.6 3.2 -2.6 4.1 3.7
Breast Cancer 4.3 10.4 16.6 4.0 -2.1 -3.9 0.0 -3.2 -3.5 -3.1 -4.1 -3.4 -3.8 -3.8 -1.6 1.8 -3.7 -3.5
Ovarian Cancer 0.2 0.3 1.0 0.0 0.2 -0.6 0.0 -0.2 -0.8 -0.2 -1.0 -0.6 -0.8 0.1 -0.7 -0.7 -0.3 -0.1
Prostate Cancer 0.5 0.8 1.8 1.2 -0.0 -0.5 0.0 -1.3 -0.7 -0.9 -0.5 -1.2 -1.1 -1.2 0.0 0.6 -1.0 -1.1
Age at First Birth 0.6 0.9 2.2 -0.8 0.7 0.8 0.0 1.1 1.1 1.5 0.8 1.0 0.6 0.9 1.2 -1.0 1.2 1.1
Bipolar Disorder (2011) 0.7 0.7 5.0 -0.4 2.2 -0.1 0.0 1.8 -0.7 0.6 -0.1 -0.1 0.1 0.2 0.1 -0.4 -0.6 -0.2
Body Mass Index (BMI) (2010) 1.5 2.1 6.5 1.3 0.1 -0.8 0.0 0.1 -1.7 -2.5 -1.5 -1.3 -1.5 -1.8 -1.2 1.7 -1.7 -1.7
Coronary Artery Disease (CAD) 3.2 3.8 9.1 1.8 -3.0 -1.3 0.0 -1.1 -1.4 -1.2 -2.8 -2.7 -2.3 -2.2 -1.9 1.0 -2.0 -2.1
Crohns Disease (2012) 0.9 1.4 4.9 2.2 -0.7 -1.2 0.0 -1.5 -0.4 -1.3 -2.1 -1.2 -1.0 -1.0 0.2 0.7 -0.8 -0.9
Mean Putamen Volume 0.3 0.3 0.8 0.6 -0.4 -0.1 0.0 -0.4 -0.6 -0.5 -0.3 -0.2 -0.5 -0.7 -0.8 0.9 -0.7 -0.8
Fasting Glucose 0.2 0.3 1.6 0.2 -0.7 -0.3 0.0 0.8 0.2 1.3 0.1 0.9 0.2 0.0 0.4 0.2 0.1 -0.3
HbA1C 1.0 1.1 4.4 0.9 -0.8 -0.6 0.0 1.1 -1.0 -1.6 -0.1 0.4 -0.1 -1.3 -0.4 2.1 -1.2 -1.5
HDL Cholesterol 0.3 0.6 3.6 0.7 1.5 -0.2 0.0 -1.9 -0.6 0.2 -0.5 -0.5 -0.1 -0.2 -0.6 0.2 -0.7 -0.5
LDL Cholesterol 0.3 0.5 4.8 -0.5 -2.2 -0.3 0.0 -0.7 -0.2 0.6 1.1 0.1 0.1 0.2 -0.5 -0.3 -0.2 0.0
Lupus 0.5 0.7 2.5 0.4 -1.6 -1.5 0.0 -0.2 -0.9 -1.0 -1.1 -0.5 -0.4 -0.6 -1.0 0.6 -0.8 -0.5
Neuroticism (2016) 0.8 1.2 4.7 0.8 -0.2 -1.0 0.0 -0.7 -1.2 -2.2 -0.4 0.5 0.4 -0.8 -0.7 1.8 -1.7 -1.5
Primary Biliary Cirrhosis 0.4 0.6 2.2 1.3 -0.3 0.4 0.0 0.2 0.7 -0.4 -0.9 0.2 0.1 -0.8 1.5 1.4 -0.1 -0.6
Rheumatoid Arthritis 0.4 0.6 2.0 -0.7 -0.6 1.1 0.0 0.6 0.4 1.1 0.3 1.4 1.2 0.5 1.0 0.2 -0.1 -0.1
Schizophrenia (2014) 0.4 0.8 4.0 0.6 -1.0 0.5 0.0 0.9 1.2 -0.2 0.1 0.9 0.6 -0.6 2.0 1.6 0.2 -0.7
Triglycerides 1.5 2.5 7.1 1.1 -2.7 -2.1 0.0 1.4 -0.6 -1.1 -0.8 -0.9 -1.0 -2.2 -0.2 2.2 -2.0 -2.4
Type 2 Diabetes (T2D) (2012) 2.1 2.4 8.2 2.2 -0.8 -1.9 0.0 0.1 -0.8 -1.2 -1.6 -0.1 0.2 -1.7 0.8 2.9 -2.2 -2.5
Ulcerative Colitis 2.7 3.9 11.7 2.7 -0.9 -2.4 0.0 -3.4 -1.6 -1.2 -2.5 -2.6 -2.5 -1.7 -1.4 -0.0 -1.4 -1.2
Blood Eosinophil Count 1.0 7.7 38.2 5.2 4.3 -2.6 0.0 -6.2 -0.2 -2.2 1.8 0.1 -1.0 -2.0 2.4 1.9 -0.7 -1.3
Blood Platelet Count 2.5 28.5 58.4 -7.6 3.1 7.0 0.0 5.8 3.7 5.6 4.5 4.7 4.3 6.5 2.6 -5.6 6.5 6.9
Blood Red Count 0.3 2.5 6.0 -2.4 2.2 1.0 0.0 1.7 0.7 0.2 0.3 1.3 2.2 2.5 1.5 -0.9 1.4 2.0
Blood White Count 0.2 1.7 6.7 -1.3 2.4 0.3 0.0 0.6 -2.6 -1.4 2.1 1.6 0.6 0.4 0.1 0.8 -1.2 -0.3
Heel T-Score 0.5 4.2 13.1 0.8 -0.3 -1.7 0.0 0.9 -2.8 -2.5 -0.6 -0.2 -0.7 -2.4 -1.2 3.4 -3.6 -3.4
BMI 1.8 10.6 18.9 3.0 0.6 -4.3 0.0 -1.0 -3.2 -4.3 -1.8 -3.1 -3.1 -4.2 -2.5 4.1 -4.3 -4.3
Height 0.8 15.6 41.6 -2.3 0.6 6.0 0.0 5.7 6.5 3.6 2.4 3.8 4.7 2.5 5.5 -0.1 4.3 2.6
Waist Hip Ratio (WHR) 2.4 11.0 21.6 2.9 -3.3 -3.3 0.0 -0.2 -3.8 -4.2 -2.7 -2.7 -2.8 -4.2 -2.5 3.9 -4.7 -4.4
Systolic Blood Pressure 0.2 0.8 4.2 0.7 0.5 -0.4 0.0 0.8 0.6 -1.3 0.9 1.0 0.8 0.2 2.0 0.9 0.4 -0.2
Smoking Status 0.5 1.2 4.0 -0.4 -2.0 -0.6 0.0 -0.5 -1.7 -1.7 -0.2 -0.5 -1.2 -1.0 -1.8 1.0 -0.8 -0.5
Allergy or Eczema 0.2 0.4 3.1 0.3 1.8 0.5 0.0 0.1 0.4 0.1 -0.1 0.4 0.6 0.6 1.2 -0.1 0.5 0.5
Cardiovascular Disease 0.4 1.3 7.4 1.0 -0.4 -1.3 0.0 1.2 0.4 -1.6 0.2 0.4 0.1 -1.6 0.5 2.7 -0.7 -1.5
Hypothyroidism (self reported) 1.4 3.3 12.4 2.5 -2.6 -2.7 0.0 -3.5 -0.9 -1.3 -1.5 -1.7 -2.2 -1.5 -0.9 0.1 -0.7 -0.8
Respiratory disease 1.6 3.6 22.8 3.7 -0.8 -1.8 0.0 -4.8 -0.5 -1.3 -0.7 -1.5 -1.1 -1.6 0.8 1.0 -1.1 -1.2
Type 2 Diabetes (T2D) (2018) 5.6 10.5 28.6 2.7 -0.7 -2.6 0.0 1.9 -3.9 -4.2 -2.8 -0.7 -1.1 -3.6 -0.8 5.2 -5.3 -5.3
Lung FEV1/FVC ratio 0.3 1.5 5.8 0.7 1.5 -0.4 0.0 2.4 -1.4 -1.0 0.0 -0.3 -0.8 -1.4 -0.5 1.5 -1.7 -1.7
Lung FVC 0.4 2.0 4.1 0.6 -1.7 1.7 0.0 -1.9 1.2 1.2 1.3 2.0 1.5 1.3 2.0 -0.6 1.6 1.2
Neuroticism 1.4 3.5 10.8 1.9 -2.0 -1.2 0.0 -1.1 -2.4 -3.3 -1.4 -1.1 -1.2 -2.1 -0.4 2.0 -2.4 -2.4
Chronotype (morning person) 3.8 8.8 18.1 3.8 -3.7 -3.4 0.0 -3.1 -1.6 -1.9 -4.2 -3.9 -4.0 -3.1 -2.9 0.5 -2.0 -2.3
Hair Pigment 0.0 1.2 2.9 0.3 -0.4 -1.0 0.0 0.2 -1.6 -1.1 -0.7 -0.5 -1.0 -1.3 -1.7 1.2 -1.6 -1.5
Tanning 0.1 0.8 1.8 -0.5 1.2 0.5 0.0 -0.2 0.9 0.2 0.2 0.4 0.5 1.2 1.3 -1.2 1.2 1.4
Hand grip strength (left) 0.6 1.5 3.8 -0.4 0.4 1.9 0.0 0.0 1.4 1.3 1.9 1.4 1.2 1.0 1.7 -0.7 1.3 1.0
Number of treatments/medications taken 0.3 0.6 1.8 -0.1 -0.3 -0.7 0.0 -0.3 -0.5 -0.5 -1.4 -1.3 -1.2 0.1 -0.6 -1.0 0.6 0.9
Average weekly spirits intake 1.4 1.7 7.8 1.7 -2.1 -0.4 0.0 -2.8 -0.2 0.4 -1.1 -1.9 -1.7 -1.1 -0.8 -0.3 -0.5 -0.6
Sensitivity / hurt feelings 0.8 1.4 2.8 1.7 -0.4 -0.9 0.0 -1.6 -1.0 -1.0 -0.1 -0.9 -1.0 -1.6 -0.7 1.3 -1.6 -1.6
Frequency of depressed mood in last 2 weeks 1.2 1.7 5.2 0.5 -2.3 -1.6 0.0 0.4 -2.1 -2.0 -1.1 -0.8 -1.0 -1.2 -0.4 0.7 -1.8 -1.3
Hearing difficulty/problems: Yes 0.7 1.1 3.9 -1.7 -1.2 2.0 0.0 1.8 0.9 0.6 0.7 0.2 0.3 0.5 0.3 -0.6 1.2 1.1
Relative age of first facial hair 2.3 4.8 10.5 -2.6 2.3 3.2 0.0 1.8 1.7 2.8 2.8 2.3 2.3 2.3 1.1 -1.6 2.0 2.0
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 6.3 2.1 -1.1 -1.4 0.0 -2.5 -0.5 -1.2 -0.9 -1.6 -1.4 -1.3 -1.3 0.5 -0.7 -1.0
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.0 0.8 -0.3 0.2 0.0 -1.0 0.6 -0.2 0.4 -0.6 -0.2 -0.7 -0.1 0.6 -0.1 -0.6
Ever had hysterectomy (womb removed) 0.8 1.0 5.1 1.1 -1.8 0.2 0.0 0.2 1.6 1.1 -0.0 -0.3 0.1 -0.5 2.2 0.4 0.3 -0.3
Systolic blood pressure, automated reading 0.6 1.7 9.1 1.6 -0.5 -0.8 0.0 0.4 1.4 -1.9 0.8 0.3 0.5 -1.7 1.1 3.0 -0.3 -1.5
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 3.8 0.7 -0.2 -1.1 0.0 0.4 -1.2 -1.9 -1.7 -0.6 -0.8 -1.5 -0.9 1.9 -1.5 -1.6
Angina 0.6 0.8 2.8 1.2 -0.7 -0.5 0.0 0.2 0.5 -0.9 -1.2 -0.6 -0.2 -1.4 -0.6 1.7 -0.8 -1.4
Medication for hormone replacement therapy 0.3 0.4 2.4 0.7 -0.6 -0.2 0.0 -1.5 -0.5 0.1 -0.8 -0.8 -0.5 -0.0 -0.5 -0.6 -0.2 0.0
Vitamin and mineral supplements 0.8 1.1 3.4 1.0 0.8 -1.0 0.0 0.3 -1.1 -1.0 0.0 0.3 0.1 -1.1 1.0 1.6 -1.8 -1.7
Supplements: Zinc 0.9 1.0 2.6 0.7 0.1 -0.5 0.0 1.4 -1.0 -1.4 -0.7 -0.8 -1.1 -1.6 -0.4 1.0 -1.1 -1.3
Medication: Co-codamol 3.1 3.6 9.1 2.7 -2.0 -0.8 0.0 -3.0 -1.5 -1.6 -2.8 -2.5 -2.6 -1.8 -1.7 0.2 -0.8 -0.9
Medication: Metformin 0.8 1.2 3.2 1.0 -0.1 -1.1 0.0 0.5 -1.1 -1.4 -1.4 0.1 -0.2 -1.1 -0.2 1.8 -1.7 -1.7
Diabetes (father) 5.1 6.3 15.5 2.8 -2.2 -1.7 0.0 0.7 -2.6 -3.2 -1.5 -1.1 -1.6 -3.3 -0.3 3.9 -3.7 -3.9
Diabetes (mother) 5.6 7.1 12.9 1.1 -1.2 -3.2 0.0 2.4 -3.6 -1.8 -3.6 -3.1 -3.2 -2.6 -3.2 1.1 -3.6 -3.0
Severe depression (siblings) 0.7 0.7 3.4 1.4 -1.8 -0.8 0.0 -1.1 0.3 -0.5 -1.2 -0.0 -0.6 -1.0 -0.2 0.7 -0.0 -0.4
Pack years adult smoking proportion 2.2 3.4 10.6 -0.1 -0.4 -1.9 0.0 -0.1 -3.3 -2.1 -2.2 -2.8 -2.3 -1.1 -2.5 -0.1 -2.3 -1.1
Impedance of leg (right) 0.1 0.3 2.4 -1.2 -0.6 -0.4 0.0 1.5 -0.0 -0.1 -0.2 -0.5 -0.3 0.1 -0.4 -0.3 0.1 0.2
Leg fat-free mass (left) 0.1 0.5 2.0 1.3 -0.1 -0.0 0.0 0.1 -0.0 -0.6 0.1 -0.4 -0.4 -1.2 0.2 1.4 -0.8 -1.2
Trunk fat percentage 2.6 10.6 20.3 3.0 -1.5 -4.4 0.0 -1.7 -3.5 -3.6 -2.1 -4.5 -3.9 -3.8 -3.0 2.5 -4.0 -3.8
Hand grip strength (right) 0.4 1.1 3.0 -0.2 0.0 1.7 0.0 0.3 1.3 1.5 1.4 0.9 0.8 0.7 1.7 -0.7 1.1 0.8
Townsend deprivation index at recruitment 1.0 1.4 5.0 0.3 -1.0 -1.2 0.0 -1.0 -2.2 -1.9 -0.5 -0.6 -0.5 -0.5 -2.2 0.6 -1.3 -0.7
Current tobacco smoking 0.4 0.7 2.1 0.4 -0.5 -0.7 0.0 0.0 -1.4 -1.5 -0.2 0.3 -0.5 -1.1 -0.1 1.3 -1.1 -1.0
Average weekly fortified wine intake 1.4 1.6 6.2 2.5 -0.8 -1.3 0.0 0.0 -0.3 -0.8 -1.0 -1.3 -1.7 -2.0 0.2 1.3 -1.2 -1.7
Maternal smoking around birth 2.1 3.1 7.9 1.2 -1.2 -1.7 0.0 -0.9 -2.8 -2.1 0.7 -0.4 -1.5 -2.4 -1.2 2.2 -2.6 -2.5
Fed-up feelings 2.8 5.1 10.1 1.4 -1.5 -2.2 0.0 0.0 -3.2 -2.8 -2.2 -2.5 -2.9 -2.7 -2.1 1.7 -2.9 -2.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 3.2 0.8 -1.7 -1.8 0.0 -0.1 -1.6 -1.2 -1.1 -0.7 -0.9 -0.8 0.6 0.2 -1.2 -0.8
Relative age voice broke 0.6 0.9 3.6 -0.8 1.5 1.5 0.0 0.3 0.1 1.1 -0.1 -0.3 0.2 1.2 -0.1 -1.9 0.8 1.1
Taking other prescription medications 0.7 1.0 8.2 1.1 -0.9 -1.1 0.0 -2.9 0.2 0.0 -1.0 -0.8 -0.8 -0.0 0.2 -0.7 0.6 0.7
Age when periods started (menarche) 0.7 1.7 3.7 -0.7 1.9 1.3 0.0 -0.4 1.2 1.8 1.8 1.9 1.9 1.5 0.4 -0.8 1.1 0.9
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 5.4 1.1 -0.2 1.3 0.0 0.5 1.9 -0.2 0.2 0.7 0.8 -0.2 2.3 0.6 0.8 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 4.3 -2.1 1.4 0.4 0.0 1.0 0.7 1.3 1.4 0.5 0.3 1.2 -1.1 -1.1 1.3 1.5
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 2.6 1.4 -0.2 -0.7 0.0 0.3 -0.3 -1.3 -1.0 -0.5 -0.2 -1.1 -0.1 1.5 -1.3 -1.6
Qualifications: CSEs or equivalent 0.7 0.9 4.2 0.9 0.5 -1.2 0.0 -0.2 -0.7 -0.9 -2.1 -1.1 -0.8 -0.9 -0.1 0.6 -1.0 -0.8
Serious illness, injury or assault to yourself 0.4 0.5 1.9 0.6 -0.4 -0.7 0.0 -0.9 -0.4 0.4 -0.9 -1.0 -1.4 -0.4 -1.2 -0.8 -0.2 -0.2
High blood pressure 0.5 1.5 5.6 2.1 0.0 -0.7 0.0 -0.0 0.8 -2.0 -0.3 0.3 0.3 -1.4 1.8 2.4 -0.5 -1.4
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.5 -0.4 1.2 -0.0 0.0 -0.1 -0.2 0.5 -0.0 -0.6 -0.2 0.6 -0.1 -0.9 0.3 0.7
Multivitamins +/- minerals 0.7 0.9 3.2 -0.7 0.6 0.6 0.0 0.8 1.1 0.8 -0.1 0.4 0.3 1.1 -0.5 -1.4 1.8 1.6
Stomach or abdominal pain in last month 0.3 0.4 2.9 0.3 -1.7 0.1 0.0 0.3 -0.4 -0.3 -1.0 -0.7 -0.8 -0.6 0.5 0.1 -0.1 0.1
Supplements: Glucosamine 1.1 1.4 5.9 -2.4 -0.0 0.4 0.0 1.1 0.6 0.7 0.0 -0.3 -0.0 1.5 -1.2 -1.8 1.5 1.8
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 3.8 0.7 -1.9 -0.1 0.0 -0.9 -0.8 -1.0 -1.5 -1.2 -0.9 -0.9 -0.5 0.4 -0.8 -0.6
Medication: Atenolol 0.5 0.6 2.1 1.5 -1.1 -0.6 0.0 -0.2 -0.3 -0.3 -1.1 -0.9 -1.0 -0.9 0.2 0.5 -0.8 -1.0
Medication: Levothyroxine sodium 1.1 1.9 5.5 1.9 -2.0 -2.2 0.0 -2.3 -0.4 -1.0 -1.3 -1.4 -1.7 -1.4 -0.5 0.4 -0.7 -0.8
Sitting height 0.4 2.6 9.1 0.0 -0.6 2.1 0.0 1.8 2.5 2.4 0.8 1.7 1.6 1.0 3.0 -0.6 1.4 0.8
Chronic bronchitis/emphysema (father) 0.8 1.0 3.6 0.2 -1.9 0.1 0.0 -0.9 -1.6 0.1 -0.5 -1.2 -1.5 -0.5 -1.6 -0.8 -0.5 -0.2
High blood pressure (mother) 0.3 0.5 3.2 0.1 0.2 0.4 0.0 1.8 0.1 0.2 -1.4 -0.3 -1.0 -0.6 -0.1 -0.0 0.3 0.1
Body mass index (BMI) 1.9 8.0 15.1 2.8 -0.5 -3.9 0.0 -1.3 -2.8 -3.5 -1.3 -3.0 -3.0 -3.7 -2.2 3.3 -3.6 -3.5
Impedance of leg (left) 0.1 0.4 2.7 -1.1 -0.6 -0.1 0.0 1.7 0.3 0.1 -0.3 -0.5 -0.3 0.2 -0.3 -0.5 0.4 0.4
Leg predicted mass (left) 0.1 0.6 2.3 1.4 -0.1 -0.0 0.0 0.1 -0.1 -0.6 0.1 -0.4 -0.4 -1.3 0.2 1.5 -0.9 -1.3
Trunk fat mass 1.6 7.0 12.9 2.7 -1.2 -3.4 0.0 -0.9 -2.4 -3.0 -1.6 -3.6 -3.1 -3.4 -2.1 2.6 -3.3 -3.3
Waist circumference 3.4 12.3 22.6 3.3 -1.7 -4.8 0.0 -0.7 -3.4 -4.1 -2.4 -3.8 -3.7 -4.6 -2.8 4.0 -4.5 -4.4
Number of incorrect matches in round 0.8 1.3 4.8 2.0 -1.1 -0.3 0.0 0.0 0.6 -1.0 0.1 0.4 0.1 -1.6 0.7 2.2 -1.0 -1.8
Past tobacco smoking 0.8 1.5 9.4 -0.2 3.1 1.5 0.0 1.2 0.4 0.4 0.8 1.6 1.6 1.0 1.6 -0.1 0.2 0.2
Alcohol usually taken with meals 0.1 0.2 1.9 0.1 -0.1 0.1 0.0 -0.1 -0.5 -0.2 -0.3 -1.4 -0.5 -0.0 0.3 -0.4 -0.8 -0.3
Nervous feelings 2.5 4.7 10.1 2.8 -1.2 -1.6 0.0 -0.4 -2.5 -3.1 -2.5 -1.3 -1.5 -2.7 -0.2 2.3 -3.1 -3.2
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.1 5.6 1.9 -2.3 -1.6 0.0 -1.0 -1.1 -2.4 -1.5 -0.5 -0.7 -1.6 -0.0 1.6 -1.3 -1.6
Hearing difficulty/problems with background noise 0.6 1.0 5.2 -1.6 -1.3 1.2 0.0 2.3 0.8 0.7 0.8 0.4 0.4 0.4 0.0 -0.2 1.0 0.8
Hair/balding pattern: Pattern 2 0.0 0.1 0.2 0.1 0.2 0.3 0.0 -0.3 0.3 -0.3 0.1 0.4 0.3 0.0 0.3 0.4 0.1 0.1
Had menopause 1.0 1.3 4.1 0.7 -1.9 -0.1 0.0 -0.1 -0.5 -1.3 -0.4 -2.0 -1.2 -1.6 -0.8 1.2 -1.2 -1.4
Had other major operations 3.5 4.3 8.3 2.2 -0.7 -1.7 0.0 -0.5 -2.4 -2.4 -2.7 -2.2 -2.0 -2.4 -1.1 2.1 -2.9 -2.8
Forced vital capacity (FVC) 0.3 1.2 3.4 0.7 -1.1 1.5 0.0 -1.0 0.9 1.1 0.0 1.0 0.9 1.2 1.9 -1.2 1.4 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.6 -1.6 1.2 0.4 0.0 1.2 0.1 0.4 0.9 0.4 -0.1 0.7 -1.3 -0.8 1.0 1.2
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.8 0.9 -0.6 0.5 0.0 0.3 -0.5 -0.6 -0.4 0.6 -0.0 -0.3 0.3 -0.0 -0.1 -0.4
Qualifications: None of the above 0.4 0.9 5.3 0.8 -0.3 -0.2 0.0 -1.5 -1.1 -2.3 -0.3 -0.8 -0.2 -0.8 -0.4 1.0 -1.1 -1.0
Financial difficulties in last 2 years 2.6 3.5 6.8 1.6 -2.6 -2.2 0.0 -0.5 -1.6 -2.5 -2.6 -1.2 -1.4 -2.1 -1.4 2.1 -1.9 -2.0
Mouth/teeth dental problems 2.8 4.3 8.0 -2.8 2.2 1.6 0.0 2.8 1.4 2.8 2.2 1.9 1.3 2.5 -0.3 -2.4 2.1 2.2
Heart attack 0.5 0.7 1.4 -1.2 1.0 0.9 0.0 0.5 0.1 0.4 0.0 0.0 0.2 1.2 -1.0 -1.2 0.9 1.2
Allergy 0.5 1.1 4.1 -1.3 -0.5 1.5 0.0 2.0 0.8 0.1 1.1 1.7 1.2 0.1 0.6 0.9 0.4 0.1
Pain all over the body in last month 1.0 1.1 4.6 1.4 1.0 -0.3 0.0 0.4 -0.7 -1.3 -0.0 0.3 -0.3 -1.5 0.7 2.1 -1.3 -1.6
Diabetes (self-reported) 2.8 4.4 11.8 1.9 0.7 -1.7 0.0 1.9 -2.7 -2.5 -3.0 -0.8 -0.7 -1.9 -0.2 2.7 -3.4 -3.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.7 -0.0 -0.8 0.4 0.0 -0.8 -0.2 0.6 -0.1 0.3 0.4 0.4 0.6 -0.5 0.1 0.3
Medication: Ramipril 0.5 0.6 3.8 -0.2 1.9 -0.7 0.0 0.7 -0.2 0.2 1.2 1.0 0.7 0.3 1.2 0.5 -0.4 -0.1
Medication: Simvastatin 0.4 0.5 2.3 -1.2 -0.8 -0.9 0.0 1.0 -0.8 -0.7 0.5 -0.3 -0.2 0.1 -1.5 0.2 -0.4 0.1
Fluid intelligence score 2.9 6.0 13.0 -1.8 0.2 3.6 0.0 1.8 3.2 2.7 1.0 2.6 2.7 2.7 3.1 -1.7 3.2 2.7
Illnesses of siblings 1.2 1.7 4.8 -1.7 1.1 1.2 0.0 0.6 0.4 1.9 0.6 1.0 0.6 1.8 -0.2 -2.2 1.5 1.8
Neuroticism score 1.1 2.3 7.0 1.6 -1.3 -1.0 0.0 -0.5 -2.4 -2.6 -1.0 -1.2 -1.4 -1.7 0.0 1.3 -2.1 -1.8
Weight 0.7 3.3 7.4 2.1 -0.4 -1.9 0.0 0.1 -1.2 -2.2 -0.9 -2.1 -1.9 -2.7 -0.8 2.6 -2.2 -2.5
Impedance of arm (right) 0.6 2.8 9.5 -0.2 -1.6 -1.5 0.0 -1.1 -2.3 -0.2 -1.9 -2.6 -2.4 -0.1 -3.1 -2.1 -0.8 0.1
Arm fat percentage (right) 3.5 14.0 27.7 3.0 -1.7 -5.3 0.0 -1.9 -4.5 -4.0 -2.6 -4.9 -4.8 -4.2 -3.9 2.5 -4.6 -4.0
Trunk fat-free mass 0.4 2.0 5.3 -0.3 0.6 2.2 0.0 2.3 2.3 1.0 0.8 1.5 1.6 0.3 2.2 1.0 1.1 0.4
Hip circumference 0.9 3.7 9.5 1.8 0.4 -3.1 0.0 -0.2 -1.6 -2.0 -1.5 -2.6 -2.3 -2.4 -1.5 1.7 -2.2 -2.2
Time employed in main current job 0.3 0.3 0.9 1.0 0.8 0.6 0.0 -0.3 -0.1 -0.1 -0.5 0.3 0.9 0.1 0.9 0.3 -0.6 -0.6
Alcohol intake versus 10 years previously 1.1 1.6 4.7 -1.1 1.2 2.2 0.0 0.4 0.7 1.3 0.6 0.9 1.1 1.8 -0.5 -1.8 1.6 1.6
Father’s age at death 1.0 1.4 3.0 1.3 0.0 -1.4 0.0 -1.5 -0.2 -1.1 -0.5 -0.7 -0.5 -1.3 -1.7 1.7 -1.4 -1.6
Worrier / anxious feelings 1.5 2.9 6.5 2.5 -1.3 -1.4 0.0 -1.4 -1.4 -2.0 -1.6 -0.7 -1.1 -2.3 0.1 2.2 -2.2 -2.4
Frequency of tiredness / lethargy in last 2 weeks 3.2 5.2 12.3 2.6 -3.5 -2.7 0.0 -1.2 -2.1 -2.5 -2.6 -2.4 -2.6 -2.8 -1.1 1.6 -2.1 -2.1
Falls in the last year 5.5 7.4 12.5 2.6 -2.7 -2.2 0.0 -1.4 -3.5 -3.1 -3.1 -3.5 -3.2 -3.1 -1.9 1.8 -3.3 -3.0
Hair/balding pattern: Pattern 3 0.3 0.5 1.3 0.1 -0.1 -0.2 0.0 1.2 0.2 -1.1 0.6 0.9 1.1 -0.0 0.7 1.0 -0.4 -0.7
Number of live births 3.9 5.5 9.6 3.1 -1.8 -2.5 0.0 -2.2 -2.3 -2.6 -2.0 -2.3 -2.4 -3.0 -0.8 2.1 -2.9 -2.9
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.9 0.8 -0.9 1.4 0.0 -0.3 0.3 0.7 -0.0 0.7 0.4 0.7 1.2 -0.9 0.9 0.6
Pulse rate 1.2 2.0 8.8 -0.8 -1.3 -1.4 0.0 0.8 -3.0 -1.3 -1.2 -0.8 -1.5 -0.8 -1.7 0.3 -2.1 -1.3
Happiness 1.2 1.5 7.1 -2.0 -1.1 0.1 0.0 1.1 -0.8 1.5 -0.2 -0.4 -0.7 1.4 -0.7 -2.7 0.6 1.5
Noisy workplace 2.2 2.7 5.1 1.8 -1.8 -2.1 0.0 -1.8 -2.0 -1.5 -1.5 -1.5 -2.2 -1.9 -1.5 0.6 -1.6 -1.3
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.0 -0.2 -0.0 0.1 0.0 0.3 0.7 1.0 0.1 1.0 0.6 0.6 0.4 -0.3 0.6 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.1 -1.1 0.1 -0.4 0.0 0.5 -0.2 1.0 -0.7 -1.2 -1.0 0.7 -1.5 -1.8 0.6 1.0
Mouth/teeth dental problems: Dentures 2.7 4.5 10.6 2.0 -2.2 -2.2 0.0 -2.3 -2.0 -3.3 -2.2 -3.0 -2.2 -2.2 -1.1 1.5 -2.0 -1.7
Asthma 0.9 1.7 17.3 2.2 0.4 -1.1 0.0 -4.2 -0.1 -0.6 -0.4 -1.1 -0.3 -0.1 0.6 -0.3 -0.1 -0.0
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 4.8 -1.1 0.9 -1.4 0.0 2.2 -1.1 0.5 -0.7 -0.6 -0.9 0.4 -1.2 -1.2 -0.3 0.3
Medication: Cholesterol lowering 0.4 0.6 2.7 -1.6 -0.5 -1.1 0.0 1.4 -0.6 0.2 0.1 -0.6 -0.6 0.3 -1.5 -0.4 -0.1 0.3
Depression (self-reported) 1.2 1.4 4.8 0.6 -1.9 -0.9 0.0 -0.3 -2.2 -1.6 -1.1 -1.0 -1.4 -1.1 -0.9 0.5 -1.3 -0.9
Medication: Lansoprazole 0.2 0.2 0.7 -0.9 0.1 -0.1 0.0 -0.4 -0.5 0.0 0.8 -0.3 -0.1 0.5 -0.5 -0.7 -0.1 0.4
Prospective memory result 2.7 3.4 6.2 -2.1 0.4 1.6 0.0 0.2 2.5 2.0 2.1 2.1 2.2 2.2 1.6 -1.0 2.4 2.3
Lung cancer (father) 0.3 0.4 1.7 0.3 -1.0 0.3 0.0 -0.2 -0.5 0.3 -0.6 -1.0 -0.9 -0.2 -1.3 -0.3 -0.3 -0.3
Illnesses of mother 1.6 2.0 6.6 -2.0 1.6 1.2 0.0 -0.3 0.8 0.0 2.2 1.8 2.6 1.9 0.6 -0.2 0.9 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.9 0.4 -0.7 1.7 0.0 0.1 1.0 0.7 0.1 1.3 0.9 0.8 1.2 -0.5 1.4 1.0
Pulse wave Arterial Stiffness index 0.4 0.5 1.5 0.4 -0.4 -0.5 0.0 0.3 -1.2 -0.8 -1.0 -1.1 -1.2 -0.7 -0.5 -0.0 -0.5 -0.4
Impedance of arm (left) 0.6 2.6 7.4 0.2 -1.6 -1.6 0.0 -1.5 -2.2 -0.5 -1.8 -2.6 -2.3 -0.4 -2.7 -1.7 -1.1 -0.4
Arm fat mass (right) 1.9 7.8 14.2 2.4 -0.9 -3.8 0.0 -0.9 -3.0 -3.2 -1.7 -3.7 -3.4 -3.4 -2.7 2.5 -3.5 -3.3
Trunk predicted mass 0.4 2.1 5.5 -0.3 0.7 2.2 0.0 2.3 2.3 1.1 0.9 1.5 1.6 0.4 2.3 0.9 1.2 0.5
Standing height 0.5 4.9 14.8 -1.2 0.0 3.9 0.0 3.0 3.5 2.6 0.5 1.6 2.2 1.6 2.8 -0.9 2.6 1.7
Length of working week for main job 2.5 2.8 6.4 -1.2 1.0 2.2 0.0 0.1 2.5 2.3 1.8 1.8 1.9 1.7 1.6 -0.6 2.0 1.6
Exposure to tobacco smoke at home 0.5 0.5 1.3 1.1 -0.7 -0.6 0.0 -0.1 -1.1 -0.7 -0.5 -0.5 -0.9 -1.0 -0.1 0.4 -0.9 -1.0
Breastfed as a baby 0.3 0.4 1.7 0.7 -0.3 -1.3 0.0 0.5 -0.2 -0.1 -0.6 -0.6 -0.6 -0.6 0.7 0.3 -0.7 -0.6
Tense / ‘highly strung’ 1.1 1.8 4.0 1.6 -1.6 -1.4 0.0 0.6 -0.7 -1.7 -0.4 -0.5 -0.8 -2.0 0.9 1.9 -1.5 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 5.4 0.2 0.0 -0.6 0.0 0.2 -2.3 -2.1 -0.2 0.3 -0.3 -0.5 -1.2 0.8 -1.3 -1.0
Hair/balding pattern: Pattern 4 1.1 2.7 5.5 1.3 -1.2 -2.3 0.0 -1.2 -2.1 -1.7 -1.1 -1.1 -1.6 -2.0 -1.3 1.6 -2.3 -2.1
Birth weight of first child 0.5 0.8 2.6 -0.2 -0.7 1.5 0.0 -0.3 1.5 0.6 -0.9 0.9 0.9 0.7 0.1 -0.5 1.6 1.2
Peak expiratory flow (PEF) 0.2 0.6 2.1 -0.1 0.1 1.5 0.0 -0.5 0.3 1.0 0.6 0.5 0.4 0.9 0.5 -1.2 0.9 0.9
Pulse wave reflection index 1.2 1.5 4.6 0.3 0.8 1.0 0.0 -0.7 2.0 0.8 1.1 0.7 1.0 1.2 1.7 -1.2 2.1 1.7
Ever highly irritable/argumentative for 2 days 1.8 2.1 7.1 1.0 -0.5 -0.8 0.0 1.3 -2.4 -2.7 -1.0 -1.2 -1.8 -1.6 -2.0 0.8 -1.3 -1.0
Loud music exposure frequency 1.2 1.3 5.4 0.1 -0.9 -0.6 0.0 1.1 -2.3 -0.9 -1.6 -1.1 -1.6 -0.9 -0.7 -0.1 -1.4 -0.8
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.7 -0.6 1.2 1.3 0.0 0.6 1.9 1.0 0.9 1.4 1.6 1.0 1.6 -0.3 1.3 0.7
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.6 0.4 0.8 1.1 0.0 -0.3 0.1 0.1 -0.1 0.2 0.7 0.2 1.3 0.1 -0.1 -0.1
Blood clot in the leg (DVT) 0.3 0.4 2.0 -0.2 -0.1 -0.5 0.0 0.6 -0.4 0.9 -1.4 -0.6 -0.8 0.3 -0.7 -1.1 -0.1 0.3
Medication: Paracetamol 0.3 0.5 1.7 0.9 0.1 -0.6 0.0 -0.6 -0.4 -1.0 -1.1 -0.0 -0.3 -0.9 -0.2 1.3 -0.7 -1.0
Headache pain in last month 0.2 0.4 1.4 0.9 -0.6 -0.1 0.0 -0.5 -1.2 -0.1 -0.7 -0.5 -0.2 -0.2 0.1 0.1 -1.1 -0.9
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.5 1.2 -0.5 -0.0 0.0 -0.9 -0.8 -0.5 -0.6 -0.7 -0.7 -0.8 -0.1 0.1 -0.8 -0.8
Glaucoma (self-reported) 1.3 1.5 4.0 1.6 1.0 -1.6 0.0 -1.6 -1.4 -2.0 -1.0 -1.1 -1.1 -0.9 -0.8 0.4 -1.2 -1.0
Gout (self-reported) 0.5 0.7 2.2 -0.3 0.4 -0.9 0.0 -0.1 -1.1 -0.7 0.6 -0.5 -0.2 -0.6 -1.5 1.2 -1.4 -1.2
Hypothyroidism/myxoedema (self-reported) 2.1 4.1 15.0 2.6 -2.9 -3.0 0.0 -3.9 -1.1 -1.6 -1.4 -2.0 -2.4 -1.8 -1.2 0.3 -1.0 -1.0
Medication: Amlodipine 0.6 0.9 4.4 1.9 -0.4 -0.0 0.0 -2.1 0.7 -0.0 -1.1 -0.1 -0.2 -0.7 1.4 0.7 0.1 -0.3
Medication: Ventolin 100micrograms inhaler 0.8 1.0 10.5 1.6 0.0 -0.5 0.0 -3.2 -0.1 -0.6 -0.4 -0.6 -0.5 0.0 0.2 -0.7 0.4 0.3
Birth weight 0.3 0.7 2.3 0.1 -0.9 1.5 0.0 -1.2 1.3 1.0 0.6 0.1 -0.3 -0.1 0.4 -0.4 1.3 0.9
Chronic bronchitis/emphysema (mother) 6.3 7.4 16.2 2.5 -2.3 -3.7 0.0 -2.6 -4.0 -2.6 -1.7 -2.1 -3.2 -2.8 -2.2 1.4 -3.6 -3.1
High blood pressure (siblings) 0.7 1.0 4.3 1.1 -0.9 -0.7 0.0 -0.7 -0.5 -2.1 -0.3 -1.1 -0.8 -1.3 -0.4 1.5 -0.8 -1.0
Forced vital capacity (FVC), Best measure 0.7 2.5 6.0 -0.2 -0.5 2.1 0.0 -0.4 2.1 1.8 0.5 1.9 1.8 1.9 1.8 -1.4 2.4 2.0
Body fat percentage 2.8 11.1 20.4 2.9 -1.6 -4.5 0.0 -1.5 -3.6 -3.9 -2.0 -4.4 -4.0 -4.0 -3.0 2.8 -4.1 -3.9
Leg fat percentage (right) 2.3 8.2 17.0 2.4 -0.8 -4.1 0.0 -0.7 -2.8 -3.7 -1.1 -3.3 -3.1 -3.8 -2.0 3.5 -3.7 -3.6
Arm fat-free mass (right) 0.3 1.4 5.2 0.6 0.7 1.2 0.0 1.7 1.7 0.1 0.7 1.0 1.3 -0.5 2.3 1.9 0.1 -0.7
Exposure to tobacco smoke outside home 0.2 0.3 0.9 0.6 -0.9 0.7 0.0 -0.5 0.5 0.3 0.6 0.2 0.4 -0.4 1.0 0.7 0.1 -0.2
Comparative body size at age 10 1.1 2.9 11.1 -0.6 -0.2 -1.8 0.0 -0.2 -3.3 -1.2 -1.4 -2.5 -2.8 -0.6 -2.9 -0.9 -1.4 0.0
Number of full brothers 4.6 5.8 9.5 3.1 -2.8 -2.1 0.0 -2.4 -2.2 -3.1 -2.4 -1.8 -1.9 -3.0 -0.1 2.6 -2.9 -2.9
Worry too long after embarrassment 0.7 1.2 3.5 1.6 -0.3 -0.8 0.0 -0.7 -1.0 -1.9 -1.1 -0.2 -0.5 -1.3 0.4 1.7 -1.2 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 1.5 0.1 -0.0 -0.7 0.0 -0.2 -0.8 -1.2 -0.5 0.5 0.6 -0.1 -0.2 0.9 -0.6 -0.5
Wheeze or whistling in the chest in last year 3.2 5.7 12.7 3.2 -1.1 -3.0 0.0 -3.6 -3.0 -2.7 -2.8 -2.2 -2.4 -2.3 -0.9 1.0 -2.5 -2.0
Number of children fathered 0.6 0.7 3.2 -1.2 0.7 0.1 0.0 1.8 -0.0 0.7 0.7 -0.1 0.1 1.0 0.3 -1.4 0.7 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 3.5 0.3 -1.2 0.8 0.0 -1.7 1.9 0.5 -0.2 -0.2 0.1 0.3 0.2 -0.6 1.9 1.5
Age at first live birth 0.4 0.7 4.1 -1.1 0.2 0.4 0.0 2.0 0.0 0.4 0.3 1.6 0.9 0.6 0.6 0.1 0.2 0.4
Pulse wave peak to peak time 0.4 0.5 1.7 -0.4 0.4 0.6 0.0 0.0 1.3 0.8 0.9 1.1 1.2 0.6 0.5 0.1 0.5 0.3
Health satisfaction 0.7 0.9 2.5 0.4 -0.0 -0.9 0.0 0.9 -1.3 -1.6 -0.9 -0.8 -1.1 -1.2 -1.0 0.9 -1.0 -1.1
Shortness of breath walking on level ground 1.5 1.7 7.3 1.3 -0.6 -0.8 0.0 0.2 -1.0 -2.7 -0.1 0.4 -0.2 -1.8 0.3 2.6 -1.3 -1.7
Qualifications: College or University degree 0.6 1.9 8.3 -0.7 0.2 0.1 0.0 2.0 1.7 2.9 0.4 1.8 1.3 1.4 1.7 -1.1 1.1 0.9
Eye problems/disorders: None of the above 2.8 3.2 6.0 -1.4 0.5 2.5 0.0 2.5 2.4 1.8 2.3 2.1 1.9 1.2 1.9 -0.2 2.1 1.5
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.7 0.4 0.1 0.7 0.0 -0.9 0.2 -0.2 -0.5 0.3 -0.1 -0.3 0.8 0.0 0.3 0.1
Emphysema/chronic bronchitis 4.5 5.0 11.2 2.3 -3.1 -3.1 0.0 -3.3 -2.9 -1.6 -2.1 -2.2 -2.7 -1.6 -1.6 -0.4 -2.1 -1.5
Medication for pain relief, constipation, heartburn 0.1 0.2 0.8 0.5 -0.7 0.6 0.0 -0.9 -0.3 -0.2 0.6 0.3 0.0 -0.2 0.5 -0.1 -0.0 0.0
Neck or shoulder pain in last month 1.1 1.6 6.8 1.7 -0.7 -1.9 0.0 -0.5 -1.7 -0.9 -2.6 -1.1 -1.0 -0.7 -0.2 -0.1 -1.6 -1.2
Medication: Blood pressure 0.3 0.6 2.3 -0.7 1.5 0.1 0.0 0.9 0.9 0.0 0.4 1.1 1.1 0.8 0.4 0.3 0.7 0.6
Angina (self-reported) 0.4 0.6 2.0 1.0 -0.5 -0.5 0.0 0.1 0.6 -0.7 -0.9 -0.4 -0.0 -1.1 -0.8 1.4 -0.5 -1.1
Migraine (self-reported) 0.9 1.1 5.6 0.1 0.7 1.2 0.0 0.1 1.0 1.0 0.2 1.7 1.7 0.8 2.4 0.4 0.5 0.2
Medication: Ibuprofen 1.0 1.2 3.8 -0.4 0.9 -1.8 0.0 1.9 -1.7 0.1 -0.8 -1.0 -1.4 -0.3 -1.3 -0.9 -1.0 -0.3
Medication: Allopurinol 1.5 1.9 4.8 1.0 0.2 -1.5 0.0 -0.3 -1.5 -1.0 0.2 -1.3 -1.2 -1.7 -2.0 1.8 -2.2 -2.2
Medication: Omeprazole 1.3 1.5 4.9 -0.4 0.2 0.7 0.0 -2.2 2.1 1.1 1.1 0.6 1.0 1.2 -0.2 -0.9 2.0 1.7
Medication: Seretide 50 evohaler 1.3 1.5 9.1 1.6 0.1 -1.6 0.0 -3.0 -1.1 -1.4 -0.7 -1.6 -0.8 -0.5 -0.4 -0.1 -0.9 -0.5
Mean time to correctly identify matches 2.0 3.9 18.1 -1.0 -1.1 1.8 0.0 1.2 4.3 0.7 1.8 2.1 2.7 1.0 2.2 1.1 2.8 1.5
Heart disease (mother) 0.5 0.6 2.6 0.1 0.0 0.3 0.0 -1.3 0.3 0.9 0.1 -0.7 -0.7 0.5 -0.8 -1.6 0.8 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 2.2 0.4 1.5 -1.0 0.0 -1.3 0.2 -0.2 1.1 0.2 0.2 -0.2 -0.1 0.5 -0.2 -0.4
Whole body fat mass 1.6 6.8 12.3 2.5 -1.2 -3.3 0.0 -0.8 -2.5 -3.1 -1.5 -3.5 -3.1 -3.4 -2.1 2.6 -3.2 -3.2
Leg fat mass (right) 1.5 5.9 10.8 2.1 -0.8 -3.2 0.0 -0.3 -2.2 -3.1 -0.9 -2.8 -2.6 -3.3 -1.9 3.0 -3.1 -3.1
Arm predicted mass (right) 0.3 1.5 5.4 0.5 0.7 1.4 0.0 1.8 1.8 0.1 0.9 1.1 1.4 -0.4 2.3 1.8 0.3 -0.5
Pulse rate, automated reading 1.3 4.3 11.5 0.4 -2.0 -2.5 0.0 0.9 -3.4 -1.4 -1.8 -2.0 -2.8 -1.8 -2.8 0.5 -3.0 -2.2
Alcohol intake frequency. 0.9 2.1 6.8 -1.4 1.2 1.7 0.0 0.8 0.3 0.9 0.5 2.6 2.1 2.1 1.7 -1.0 1.3 1.7
Comparative height size at age 10 0.3 1.8 5.5 1.1 -1.3 -0.2 0.0 1.6 -1.0 -1.8 -2.4 -1.4 -1.4 -1.6 -0.6 1.3 -1.2 -1.3
Number of full sisters 1.5 1.8 5.1 1.2 -2.0 -1.5 0.0 -2.3 -1.3 -1.2 -1.4 -1.5 -1.7 -0.9 -1.4 -0.5 -0.8 -0.4
Suffer from ‘nerves’ 1.2 1.9 5.0 2.2 -1.5 -1.4 0.0 -0.5 -0.6 -1.6 -1.9 -1.1 -1.3 -1.9 -0.2 1.3 -1.3 -1.7
Overall health rating 1.3 2.9 6.8 2.3 -1.4 -2.6 0.0 -0.7 -1.3 -2.2 -1.9 -1.1 -1.6 -2.2 -0.6 1.7 -1.7 -2.0
Chest pain or discomfort 0.1 0.1 0.5 -0.3 -0.7 -0.4 0.0 -0.4 -0.2 -0.2 -0.0 0.6 0.2 0.4 -0.3 -0.3 0.4 0.4
Had major operations 1.1 1.2 4.2 -1.7 0.2 1.3 0.0 1.0 1.0 0.5 1.3 1.6 2.1 1.1 1.1 0.4 0.6 0.5
Age at last live birth 0.7 1.0 3.1 0.4 -0.6 -1.0 0.0 1.5 -1.2 -0.9 -0.4 0.1 0.1 -0.9 0.4 1.5 -1.8 -1.6
Family relationship satisfaction 0.4 0.5 2.3 -0.8 -0.2 0.6 0.0 0.6 -0.2 0.2 -0.5 -0.0 -0.1 0.7 1.5 -1.2 0.4 0.9
Leg pain on walking 0.4 0.5 2.4 0.4 0.5 -0.1 0.0 -1.5 -1.1 -1.5 0.4 -0.5 -0.3 0.2 -0.9 -0.5 0.1 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.4 -0.6 0.0 -0.6 0.0 -1.2 -0.1 0.8 0.2 -0.4 -0.6 0.3 -1.0 -0.8 0.4 0.7
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.4 0.9 -0.5 -0.8 0.0 0.2 0.2 -0.7 0.1 -0.1 -0.3 -1.0 0.6 1.2 -0.2 -0.7
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 4.7 -0.5 1.1 1.1 0.0 -0.5 1.7 1.1 2.2 1.3 1.5 1.1 1.8 -0.6 1.4 1.2
Medication: Aspirin 0.4 0.6 2.5 0.3 -0.7 -0.3 0.0 1.2 0.1 -0.3 -1.6 -1.4 -0.7 -0.6 -0.9 0.1 -0.3 -0.5
Supplements: Vitamin C 0.3 0.3 1.3 -0.0 -0.7 0.1 0.0 -0.3 0.1 -0.5 -0.4 -1.1 -0.8 -0.6 -1.1 0.4 -0.1 -0.3
Knee pain experienced in last month 1.0 1.5 4.4 0.2 -0.1 -1.2 0.0 -0.4 -2.0 -1.4 -2.1 -2.1 -1.4 -0.3 -1.6 -0.5 -1.0 -0.4
Hypertension (Self-reported) 0.4 1.0 4.4 1.4 -0.1 -0.5 0.0 0.3 1.3 -1.5 -0.1 0.4 0.5 -1.1 1.6 2.1 0.0 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 5.0 -0.1 -1.1 -0.1 0.0 -0.7 -0.4 -0.1 -0.9 -1.4 -0.9 -0.3 -2.2 -0.5 -0.1 -0.0
Illnesses of father: Heart disease 2.6 3.6 6.7 1.5 -2.6 -1.7 0.0 -0.3 -2.4 -2.2 -2.6 -2.0 -2.3 -2.0 -1.8 0.9 -2.0 -1.8
Illnesses of siblings: Diabetes 5.2 6.4 13.4 2.4 -1.9 -2.8 0.0 -1.5 -2.6 -3.7 -2.9 -2.4 -1.9 -2.8 -1.5 3.0 -3.3 -3.1
Smoking status: Previous 0.4 0.6 2.8 -0.9 -1.7 -0.3 0.0 -0.3 0.4 0.5 -0.0 -0.9 -0.6 0.1 -1.3 -0.7 0.7 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 1.3 0.5 -0.8 0.0 0.0 0.6 -0.2 0.6 -1.1 -0.3 -0.5 -0.2 1.1 -0.3 -0.2 -0.1
Whole body fat-free mass 0.1 0.8 2.5 0.5 0.4 1.2 0.0 1.5 1.4 0.3 0.5 0.7 0.8 -0.5 1.6 1.4 0.2 -0.4
Leg fat-free mass (right) 0.1 0.5 2.1 1.4 -0.0 0.3 0.0 0.1 0.1 -0.4 -0.1 -0.3 -0.3 -1.1 0.4 1.2 -0.7 -1.1
Arm fat percentage (left) 3.6 14.4 27.9 3.1 -1.7 -5.3 0.0 -2.1 -4.6 -4.1 -2.6 -4.9 -4.7 -4.3 -3.8 2.6 -4.8 -4.2
Average weekly red wine intake 0.7 1.1 4.9 1.3 -0.4 -0.4 0.0 -0.3 0.5 -1.2 0.6 -0.3 0.0 -1.4 1.1 2.2 -1.1 -1.6
Handedness (chirality/laterality): Left-handed 0.6 0.8 2.7 0.5 -0.2 -0.0 0.0 0.3 1.6 1.0 0.7 0.8 0.9 0.8 1.6 -0.6 1.2 0.9
Mood swings 0.1 0.3 1.5 -0.5 0.5 -0.4 0.0 0.5 -1.2 -0.5 -0.1 -0.1 -0.1 0.5 0.3 -0.9 -0.2 0.4
Loneliness, isolation 2.7 3.8 9.9 1.5 0.7 -1.6 0.0 1.2 -3.1 -3.1 -2.1 -1.5 -1.6 -2.1 -0.4 1.9 -2.7 -2.3
Long-standing illness, disability or infirmity 1.5 2.3 3.7 1.9 -1.4 -1.8 0.0 -0.8 -1.7 -1.9 -1.8 -1.7 -1.6 -1.7 -1.2 1.0 -1.5 -1.5
Ever had bowel cancer screening 2.8 3.3 8.5 2.2 -2.4 -2.1 0.0 -2.9 -0.9 -1.1 -1.4 -2.3 -1.8 -1.9 -1.7 0.9 -1.6 -1.8
Diabetes diagnosed by doctor 3.7 6.1 15.4 2.3 -0.0 -2.3 0.0 1.6 -3.3 -3.4 -2.7 -1.0 -1.3 -2.5 -1.1 3.2 -3.9 -3.6
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.1 4.2 1.6 -2.0 -1.6 0.0 -1.4 -1.4 -1.3 -2.1 -1.2 -1.6 -1.5 -1.4 0.7 -1.3 -1.3
Friendships satisfaction 0.5 0.6 2.4 -0.8 -0.8 -0.8 0.0 0.6 -1.6 -1.3 -1.3 -0.3 -0.2 0.2 0.2 -0.2 -0.9 -0.1
Qualifications: nursing, teaching 0.4 0.5 1.7 -0.9 -0.4 0.2 0.0 1.3 1.1 0.8 0.4 0.3 0.2 0.7 -0.1 -0.6 1.2 1.0
Commuting to job workplace: Walk 0.6 0.7 2.4 -0.8 0.9 1.1 0.0 -0.8 -0.3 0.7 0.7 -0.1 0.5 1.4 -1.0 -1.5 0.3 0.8
Eye problems/disorders: Cataract 0.8 0.9 3.7 -0.2 0.1 -1.6 0.0 -1.9 -1.0 -0.5 -0.4 -0.9 -0.7 -0.1 -1.9 -0.2 -0.7 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.6 -0.3 0.4 0.2 0.0 -0.2 1.3 0.1 -0.3 1.2 1.1 0.3 0.7 0.8 0.9 0.5
Medication for cholesterol 0.2 0.2 0.8 -0.2 0.8 0.2 0.0 -0.8 0.0 0.9 0.3 0.3 0.5 0.6 -0.9 -0.4 0.1 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 4.9 0.8 -2.2 -0.9 0.0 -0.6 -1.2 -1.7 -0.8 -1.7 -1.3 -1.1 -0.6 0.6 -1.0 -0.9
Back pain experienced in last month 0.7 1.0 3.1 -1.4 0.5 -0.1 0.0 1.7 0.1 1.1 0.0 -0.7 -0.7 0.7 -1.6 -1.8 0.9 1.0
Mineral and other dietary supplements 0.7 0.9 3.1 1.7 -0.1 -1.0 0.0 -1.8 -1.2 -0.5 -0.1 -0.0 -0.6 -0.8 0.6 0.5 -1.3 -1.0
Breast cancer (self-reported) 2.5 3.0 7.8 -2.8 1.3 2.4 0.0 0.8 0.3 1.7 2.5 1.4 1.4 2.3 -0.3 -1.9 1.6 2.2
Asthma (self-reported) 0.8 1.5 15.8 2.0 0.6 -0.9 0.0 -4.0 -0.1 -0.3 -0.4 -1.0 -0.1 0.1 0.8 -0.5 -0.1 0.1
Osteoporosis (self-reported) 0.4 0.5 2.2 0.3 -1.0 0.2 0.0 -0.3 1.0 0.9 0.3 0.7 0.6 0.1 1.5 0.4 0.5 0.2
Osteoarthritis (self-reported) 0.5 0.6 3.2 -0.3 -0.4 -0.4 0.0 -1.4 -0.4 -0.2 -0.9 -1.3 -0.9 0.1 -1.8 -0.5 0.0 0.3
Medication: Aspirin 0.3 0.4 1.7 -0.0 -0.2 -0.3 0.0 1.3 0.1 0.0 -1.2 -1.2 -0.6 -0.4 -1.0 0.0 -0.1 -0.2
Medication: Gliclazide 2.6 3.0 8.6 1.3 -0.5 -2.3 0.0 -0.5 -2.0 -1.1 -1.3 -1.8 -1.5 -2.1 -1.1 1.9 -2.9 -2.6
Illnesses of father: None of the above (group 1) 0.9 1.1 2.1 -0.8 1.1 1.2 0.0 -0.3 1.3 1.2 0.8 0.7 0.9 1.1 1.0 -1.0 1.4 1.5
Smoking status: Current 0.3 0.5 1.4 0.4 -0.7 -0.5 0.0 -0.1 -1.1 -1.2 -0.1 0.5 -0.4 -0.9 0.0 1.2 -0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 4.0 0.3 0.1 1.5 0.0 -0.9 1.3 0.5 0.5 1.8 1.8 1.2 2.0 -0.2 1.5 1.2
Whole body water mass 0.1 0.8 2.7 0.4 0.5 1.3 0.0 1.4 1.4 0.2 0.5 0.7 0.9 -0.4 1.6 1.4 0.3 -0.3
Leg predicted mass (right) 0.1 0.5 2.2 1.5 -0.0 0.2 0.0 0.1 0.1 -0.4 -0.1 -0.3 -0.3 -1.1 0.4 1.3 -0.7 -1.1
Arm fat mass (left) 2.1 8.6 15.7 2.5 -1.0 -4.0 0.0 -0.8 -3.2 -3.4 -2.0 -3.8 -3.5 -3.6 -2.6 2.6 -3.8 -3.5
Number of self-reported non-cancer illnesses 4.9 8.5 15.5 3.8 -2.3 -3.9 0.0 -1.9 -2.5 -3.2 -3.3 -3.2 -3.0 -3.5 -1.6 2.5 -3.3 -3.3
Average weekly champagne plus white wine intake 1.5 2.0 4.6 -1.5 1.6 1.5 0.0 1.3 1.4 1.5 1.1 0.6 0.4 1.6 0.6 -2.0 2.0 2.1
Miserableness 0.1 0.1 0.4 0.1 -0.2 -0.1 0.0 -0.1 -0.4 -0.4 0.6 0.6 0.2 0.2 0.6 -0.0 0.2 0.2
Guilty feelings 2.8 4.2 11.7 2.0 -0.9 -0.9 0.0 -0.1 -3.0 -3.4 -2.0 -1.7 -1.9 -2.6 -1.4 2.2 -2.6 -2.5
Wears glasses or contact lenses 0.3 0.3 1.3 -0.8 -0.7 0.8 0.0 -1.1 0.7 -0.2 0.5 -0.6 0.3 0.1 0.5 0.6 0.2 0.2
Ever taken oral contraceptive pill 0.6 0.7 2.7 -0.5 0.4 -1.1 0.0 -1.6 -0.5 1.0 0.9 -0.1 -0.6 0.6 -1.0 -1.2 0.3 0.8
Hearing aid user 2.6 2.9 6.8 -2.2 0.1 1.3 0.0 1.4 2.0 2.3 1.3 1.1 0.8 1.9 0.5 -2.3 2.6 2.5
Mother’s age at death 0.2 0.2 1.0 0.3 -0.6 -0.4 0.0 1.0 1.0 0.5 0.0 0.2 -0.2 -0.4 0.5 0.4 0.3 -0.1
Financial situation satisfaction 2.0 2.5 6.7 1.2 -1.4 -1.3 0.0 -1.6 -2.6 -2.1 -1.9 -1.2 -1.2 -1.4 -1.0 0.8 -2.3 -1.9
Tinnitus: Yes, now most or all of the time 1.0 1.1 6.9 -0.1 -1.1 -0.7 0.0 -0.4 -0.9 -0.8 -0.2 -1.7 -1.6 -0.9 -2.6 -0.0 -0.7 -0.6
Commuting to job workplace: Public transport 3.9 4.7 10.6 -1.3 -0.3 2.7 0.0 -2.2 2.4 3.3 2.2 1.4 1.8 2.6 1.0 -2.7 2.6 2.7
Eye problems/disorders: Glaucoma 1.7 2.0 4.7 1.9 0.9 -2.2 0.0 -2.1 -1.6 -2.1 -1.5 -1.3 -1.4 -0.8 -1.0 0.0 -1.3 -1.0
Medication: Blood pressure 0.4 0.7 3.5 1.0 -0.8 0.0 0.0 0.6 0.1 -1.4 -0.3 -0.3 -0.5 -1.1 1.9 1.0 -0.3 -0.5
Pain type(s) experienced in last month: Hip pain 3.2 4.0 9.7 0.7 -2.7 -3.0 0.0 -1.8 -1.8 -1.6 -2.0 -3.1 -2.8 -1.6 -2.9 -0.0 -1.2 -0.6
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.7 -1.2 0.3 0.3 0.0 1.3 0.1 0.0 -0.4 -0.8 -0.1 0.3 -1.0 -0.4 0.3 0.4
High cholesterol (Self-reported) 0.4 0.7 2.0 -0.1 -1.4 -0.6 0.0 1.3 -0.3 -0.7 -0.3 -0.8 -0.7 -1.0 -0.3 1.3 -1.0 -1.1
Medication: Bendroflumethiazide 0.4 0.6 3.3 -0.5 -0.6 0.1 0.0 1.8 0.1 -1.3 0.7 0.3 -0.0 -0.7 0.7 1.2 -0.1 -0.3
Medication: Paracetamol 0.1 0.2 0.9 0.1 0.1 -0.1 0.0 -0.3 -0.2 -0.7 -0.8 0.5 0.2 -0.3 0.3 0.9 -0.4 -0.4
Medication: Lisinopril 0.2 0.3 1.9 -1.2 -0.2 0.1 0.0 1.4 0.3 -0.1 0.2 0.1 0.0 0.3 0.1 -0.0 0.3 0.5
Medication: Atorvastatin 0.2 0.3 1.0 -0.1 -0.8 -0.3 0.0 0.9 0.5 0.3 -0.1 0.0 -0.3 -0.8 0.2 1.0 -0.2 -0.6
Illnesses of father: High blood pressure 0.4 0.5 1.2 1.1 0.9 -0.6 0.0 -1.0 1.0 -1.1 -0.1 0.5 0.3 -0.4 0.4 0.8 0.3 -0.4
Alcohol drinker status: Never 0.5 0.6 1.6 -0.0 0.8 -0.2 0.0 1.0 -0.2 -0.6 0.4 0.8 1.0 -0.2 0.2 1.3 -1.2 -1.1
Ever smoked 1.3 2.3 5.2 0.7 -2.3 -2.2 0.0 -0.8 -1.2 -1.1 -1.3 -2.1 -2.1 -1.6 -2.0 0.6 -1.2 -1.1
Basal metabolic rate 0.1 0.6 2.8 0.9 0.3 0.4 0.0 1.2 0.6 -0.4 0.0 -0.0 0.0 -1.0 0.9 1.7 -0.5 -0.9
Leg fat percentage (left) 2.0 7.2 14.6 2.3 -0.7 -3.8 0.0 -0.7 -2.5 -3.4 -1.0 -3.1 -3.0 -3.6 -1.9 3.3 -3.4 -3.4
Arm fat-free mass (left) 0.2 0.9 3.2 0.3 0.7 0.8 0.0 1.8 1.2 -0.1 0.6 0.5 0.8 -0.5 1.7 1.6 0.0 -0.5
Number of operations (self-reported) 0.9 1.3 3.8 0.1 -1.2 0.6 0.0 1.5 -0.9 -1.7 -1.5 -0.1 0.2 -1.0 -0.2 2.0 -1.5 -1.6
Average weekly beer plus cider intake 0.8 1.1 6.4 0.4 -0.2 -1.4 0.0 0.1 -1.2 -0.8 -1.4 -0.9 -1.2 -0.8 -2.5 0.0 -0.7 -0.7
Irritability 0.7 1.1 3.4 -0.7 -0.4 1.5 0.0 0.4 0.5 -0.3 1.8 1.6 1.6 1.1 1.6 0.0 0.8 0.7
Risk taking 1.3 2.0 5.5 1.1 -2.0 -1.7 0.0 0.5 -1.5 0.2 -1.1 -2.3 -2.3 -1.5 -1.1 -0.2 -1.3 -1.1
Ever had prostate specific antigen (PSA) test 1.5 1.7 4.5 -2.1 0.8 1.6 0.0 0.1 0.5 1.4 0.8 0.4 0.7 1.9 0.5 -2.1 1.4 2.0
Fractured/broken bones in last 5 years 0.2 0.2 1.5 -0.5 0.2 0.5 0.0 1.2 0.1 0.1 0.2 0.7 0.7 0.4 0.6 -0.1 0.0 0.0
Age started oral contraceptive pill 0.3 0.3 1.3 0.5 -0.7 0.2 0.0 -1.1 -0.1 -0.1 -1.0 -1.0 -0.4 -0.3 -0.5 -0.2 -0.1 -0.1
Diastolic blood pressure, automated reading 0.3 0.9 4.6 1.0 -0.8 -0.6 0.0 0.4 0.4 -1.0 0.6 0.2 -0.1 -1.5 0.6 2.1 -0.7 -1.4
Ever depressed for a whole week 0.4 0.4 2.4 0.3 -0.0 1.0 0.0 0.3 0.4 -0.8 -0.0 1.1 0.8 0.2 1.5 0.3 0.6 0.3
Unable to work because of sickness or disability 0.9 1.2 4.0 1.8 -1.4 -0.2 0.0 -0.8 -0.9 -2.0 -1.4 -1.0 -0.8 -1.2 0.9 0.8 -0.6 -0.9
Commuting to job workplace: Cycle 1.1 1.3 4.3 -2.1 0.2 0.3 0.0 0.8 0.5 1.4 -0.1 -0.8 -0.2 1.4 -1.0 -2.0 1.3 1.9
Myopia 0.5 0.7 3.0 1.3 -0.4 -0.7 0.0 -0.2 0.2 -0.6 -0.6 -0.0 0.0 -1.3 -0.1 1.7 -1.0 -1.3
Vascular/heart problems diagnosed by doctor 0.4 1.1 4.5 -1.5 -0.4 0.4 0.0 -0.2 -1.1 1.6 -0.2 -0.6 -0.6 1.1 -1.5 -2.1 0.1 1.0
Cholesterol lowering medication 0.5 0.7 1.7 0.1 -1.3 -0.9 0.0 1.2 -0.5 -0.7 -0.5 -1.0 -0.9 -1.0 -0.7 0.9 -0.9 -0.9
Medication: Omeprazole (e.g. Zanprol) 1.0 1.3 6.2 -0.0 0.3 0.3 0.0 -2.5 1.5 1.0 0.5 0.1 0.6 1.2 -0.5 -1.4 1.7 1.5
Pain experienced in last month 0.5 0.8 2.4 -0.5 -0.4 0.7 0.0 -1.2 1.6 0.4 1.4 1.2 0.9 0.5 0.8 0.0 1.1 0.8
Supplements: Calcium 0.7 0.8 2.8 0.9 0.3 -0.7 0.0 1.0 0.9 -0.5 0.5 1.4 0.9 -0.3 1.7 1.4 -0.1 -0.7
Basal cell carcinoma (self-reported) 0.5 0.6 2.0 0.0 0.6 0.7 0.0 -0.7 0.5 -0.3 0.9 1.2 1.3 0.9 1.4 0.1 0.6 0.6
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.2 -1.0 0.9 0.8 0.0 0.4 -0.0 0.3 -0.0 -0.1 0.2 1.1 -0.9 -1.1 0.7 1.0
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.0 -0.4 0.3 -0.2 0.0 0.7 -0.4 1.0 -1.4 -0.4 -0.6 0.6 -0.6 -1.4 0.1 0.6
Heart disease (siblings) 0.1 0.1 0.6 0.0 -0.6 0.8 0.0 -0.4 0.1 0.5 -0.0 -0.0 0.3 0.2 0.5 -0.1 -0.2 -0.2
Alcohol drinker status: Previous 1.4 1.6 3.5 -0.9 -0.7 0.8 0.0 -1.6 0.4 1.0 1.2 1.5 1.1 1.8 1.0 -1.8 1.4 1.9
Pack years of smoking 2.2 3.3 9.2 -0.3 -0.6 -1.8 0.0 -0.4 -3.0 -1.9 -2.0 -3.0 -2.3 -0.9 -2.7 -0.3 -2.1 -1.0
Impedance of whole body 0.1 0.7 2.1 -0.4 -1.0 -0.8 0.0 -0.1 -0.9 0.0 -1.0 -1.4 -1.1 0.1 -1.4 -1.4 -0.2 0.2
Leg fat mass (left) 1.4 5.5 10.4 2.1 -0.8 -3.0 0.0 -0.2 -2.0 -3.0 -0.9 -2.8 -2.6 -3.2 -2.0 2.9 -2.9 -3.0
Arm predicted mass (left) 0.2 1.1 4.0 0.4 0.7 0.9 0.0 2.0 1.5 -0.2 0.5 0.6 0.9 -0.6 1.9 1.8 0.1 -0.6