TWAS hub - CYP26A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1150	0.0340	6.6e-06	0.049	0.057	0.054	0.055	0.043	1.2e-06	1.9e-07	3.8e-07	2.6e-07	5.5e-06
2	ROSMAP	Brain Pre-frontal Cortex	0.0556	0.0222	1.1e-03	0.016	0.025	0.011	0.023	0.010	3.1e-03	3.2e-04	1.1e-02	4.9e-04	1.7e-02
3	TCGA	Brain Lower Grade Glioma	0.0657	0.0386	4.9e-03	0.021	0.019	0.029	NA	0.023	1.8e-03	2.4e-03	2.8e-04	NA	1.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Eye problems/disorders: Glaucoma	9.0	10.7	17.2	-4.2	-3.7	-1.0
Glaucoma (self-reported)	6.5	7.7	12.0	-3.3	-3.5	-0.2
Hearing aid user	6.0	6.8	16.6	0.8	1.7	4.1
Medication: Bendroflumethiazide	5.3	8.1	13.9	1.7	2.7	3.7
Medication for hormone replacement therapy	5.2	5.8	9.1	-1.7	-3.0	-2.3
Worrier / anxious feelings	4.6	8.6	11.2	-3.3	-1.9	-3.3
Eye problems/disorders: Cataract	4.6	5.3	12.9	-1.7	-3.6	-0.5
Eye problems/disorders: None of the above	4.5	5.1	10.8	2.0	3.3	0.7
Asthma (self-reported)	4.5	9.0	14.7	0.7	-3.4	-3.8
High cholesterol (Self-reported)	4.4	7.7	13.5	1.3	2.8	3.7
Triglycerides	4.3	7.0	14.1	0.6	2.6	3.8
Asthma	4.2	8.3	13.4	1.1	-3.2	-3.7
Medication: Seretide 50 evohaler	3.5	4.0	6.2	-0.1	-2.5	-2.4
Mineral and other dietary supplements	3.5	4.7	6.4	-1.3	-2.4	-2.5
Respiratory disease	3.3	7.3	11.9	1.4	-2.9	-3.5
Supplements: Glucosamine	3.1	4.0	6.2	0.8	2.3	2.5
Hearing difficulty/problems: Yes	2.8	4.3	9.1	0.9	1.7	3.0
Medication: Co-codamol	2.8	3.2	7.1	-1.4	-2.7	-0.8
Illnesses of father: Heart disease	2.7	3.8	6.1	-2.5	0.6	2.2
Medication: Cholesterol lowering	2.6	4.1	6.3	1.3	2.1	2.5
Townsend deprivation index at recruitment	2.5	3.5	7.5	-0.8	-1.5	-2.7
Qualifications: nursing, teaching	2.5	3.9	6.3	2.5	1.5	1.7
LDL Cholesterol	2.4	3.8	6.6	0.4	2.2	2.6
Mouth/teeth dental problems	2.4	3.6	7.5	0.5	1.8	2.7
Number of full brothers	2.4	3.0	4.8	-0.1	-2.2	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.8	3.1	-1.8	-1.7	-1.6
Blood Eosinophil Count	2.3	17.9	33.9	0.6	-4.4	-5.8
Wheeze or whistling in the chest in last year	2.3	4.1	8.8	0.8	-3.0	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	4.9	0.8	1.5	2.2
Back pain experienced in last month	2.3	3.4	6.0	1.7	1.2	2.5
HDL Cholesterol	2.2	3.7	8.2	-0.4	-1.6	-2.9
Ulcerative Colitis	2.1	3.0	4.7	-0.6	-2.2	-1.9
Had menopause	2.1	2.6	6.6	0.5	1.0	2.6
Hair/balding pattern: Pattern 3	2.1	3.2	4.6	1.3	2.1	1.8
Headache pain in last month	2.1	3.7	6.9	-2.0	-0.4	-2.6
Guilty feelings	2.0	3.1	4.1	-1.6	-2.0	-1.5
Type 2 Diabetes (T2D) (2012)	1.9	2.2	5.6	-2.4	-0.6	-0.8
Vitamin and mineral supplements	1.9	2.6	3.8	-2.0	-1.2	-1.6
Chronic bronchitis/emphysema (father)	1.9	2.2	5.3	2.3	0.9	0.8
Supplements: Fish oil (including cod liver oil)	1.9	2.5	3.9	-0.1	2.0	1.9
Rheumatoid Arthritis	1.8	2.5	3.8	1.9	1.6	1.2
Ever had hysterectomy (womb removed)	1.8	2.1	3.2	-0.0	1.7	1.8
Verbal and Numeric Reasoning (VNR)	1.7	4.1	7.6	1.2	2.8	1.8
Blood Platelet Count	1.7	19.5	41.2	1.0	4.0	6.4
Average weekly spirits intake	1.7	2.1	4.9	-1.0	-0.7	-2.2
Sensitivity / hurt feelings	1.7	2.9	4.6	-1.5	-2.1	-1.4
Coronary Artery Disease (CAD)	1.6	1.9	3.3	-0.2	1.8	1.5
Noisy workplace	1.6	2.0	3.0	-0.7	-1.6	-1.7
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	3.5	-0.9	-1.3	-1.9
Medication: Gliclazide	1.6	1.8	4.8	-0.8	-0.3	-2.2
Commuting to job workplace: Public transport	1.6	1.9	4.7	-0.8	-0.6	-2.2
Alzheimer’s Disease (in mother)	1.5	1.8	4.0	-2.0	-0.3	1.1
Irritable Bowel Disease (IBD)	1.5	3.5	6.1	-0.6	-2.0	-2.5
Hearing difficulty/problems with background noise	1.5	2.4	3.7	0.1	1.9	1.9
Pulse rate	1.5	2.6	3.0	1.4	1.7	1.7
Happiness	1.5	1.9	5.2	-0.0	2.3	0.6
Mouth/teeth dental problems: Dentures	1.5	2.6	4.0	-0.4	-2.0	-1.9
Illnesses of siblings: Diabetes	1.5	1.8	3.8	-1.9	-1.1	-0.7
Illnesses of father: None of the above (group 1)	1.5	1.9	3.2	-0.5	-1.8	-1.5
Illnesses of mother	1.4	1.7	3.2	-0.7	-1.2	-1.8
Friendships satisfaction	1.4	1.8	3.4	0.9	1.9	1.1
Medication for cholesterol	1.4	2.2	4.6	0.9	-1.1	-2.1
Osteoarthritis (self-reported)	1.4	1.8	3.4	-1.4	-0.2	-1.8
Cholesterol lowering medication	1.4	2.0	2.7	-1.2	1.6	1.4
Neuroticism (2016)	1.3	1.9	4.9	-0.9	0.1	-2.2
Financial difficulties in last 2 years	1.3	1.8	3.8	-1.2	-0.2	-2.0
Fluid intelligence score	1.3	2.8	6.7	0.3	2.6	1.2
Mean time to correctly identify matches	1.3	2.4	4.3	0.7	2.1	1.6
Fasting Glucose	1.2	1.4	2.5	1.2	1.6	0.5
Diabetes (self-reported)	1.2	1.8	2.5	-1.5	-0.7	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.4	-1.0	-1.9	-1.3
Leg pain on walking	1.2	1.4	2.0	1.3	-1.4	-0.8
Commuting to job workplace: Walk	1.2	1.3	1.9	-0.6	-1.4	-1.3
Medication: Blood pressure	1.2	2.3	5.1	-0.1	1.3	2.3
Ever had prostate specific antigen (PSA) test	1.2	1.3	1.7	1.0	1.1	1.3
Myopia	1.2	1.7	3.1	-1.8	-1.3	-0.5
Crohns Disease (2017)	1.1	2.4	4.3	-0.5	-1.6	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	5.8	-1.3	-2.4	0.7
Comparative body size at age 10	1.1	3.1	4.2	-1.8	-2.0	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.8	-0.2	-1.7	-1.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.2	0.6	1.5	1.1
Ever had bowel cancer screening	1.1	1.3	2.0	1.4	0.9	1.0
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.1	-0.9	-1.4	-1.1
Alcohol drinker status: Previous	1.1	1.3	3.4	-1.9	-0.5	-0.4
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.1	-1.3	0.1	-2.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.6	-1.6	-0.6	-1.4
Medication: Lisinopril	1.0	1.3	3.7	0.0	1.9	0.6
Mean Putamen Volume	0.9	1.0	2.3	-0.3	-1.5	-0.7
Lupus	0.9	1.4	2.6	1.2	0.4	1.6
Heel T-Score	0.9	6.9	12.2	-3.5	-1.5	2.5
Cardiovascular Disease	0.9	3.0	7.0	-0.3	1.4	2.6
Systolic blood pressure, automated reading	0.9	2.6	3.7	0.9	1.8	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	4.0	-1.1	-2.0	1.1
Hayfever, allergic rhinitis or eczema	0.9	1.9	3.5	1.9	0.9	1.2
Hair/balding pattern: Pattern 2	0.9	1.1	1.4	1.2	-1.1	-0.9
Medication: Ramipril	0.9	1.1	2.1	-1.4	-0.8	-0.8
Medication: Simvastatin	0.9	1.3	3.2	0.3	1.8	0.7
Alcohol intake versus 10 years previously	0.9	1.3	2.7	0.4	-1.0	-1.6
Medication: Lansoprazole	0.9	1.0	2.2	-0.9	1.5	0.3
Breastfed as a baby	0.9	1.2	2.0	1.0	0.7	1.4
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.2	1.5	-1.1	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.8	-0.7	-0.5	-1.7
Suffer from ‘nerves’	0.9	1.4	2.4	-1.6	-1.3	-0.0
Diabetes diagnosed by doctor	0.9	1.5	2.5	-1.6	-0.4	-1.4
Average weekly champagne plus white wine intake	0.9	1.3	3.5	1.9	-0.0	0.6
Alzheimer’s Disease (including proxy)	0.8	1.1	2.6	-1.6	-0.1	0.8
Impedance of leg (right)	0.8	3.7	6.3	1.4	1.6	2.5
Maternal smoking around birth	0.8	1.2	1.8	-0.5	-1.2	-1.3
Taking other prescription medications	0.8	1.2	2.0	1.2	-1.4	0.3
Forced vital capacity (FVC)	0.8	3.0	4.8	0.6	2.2	-1.9
Falls in the last year	0.8	1.1	2.5	1.6	0.5	-0.7
Lung cancer (father)	0.8	0.9	1.3	0.8	1.2	0.9
Tense / ‘highly strung’	0.8	1.4	3.4	-0.0	1.8	0.9
Loud music exposure frequency	0.8	0.9	1.0	0.9	1.0	0.9
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	1.9	1.3	-0.5	-1.4
Forced vital capacity (FVC), Best measure	0.8	2.9	6.2	-0.2	1.5	-2.5
Qualifications: College or University degree	0.8	2.5	6.3	-0.0	2.5	1.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.9	-1.0	-0.5	-1.4
Miserableness	0.8	1.3	2.1	-1.4	-0.7	-1.2
Medication: Atorvastatin	0.8	1.0	2.6	0.2	0.6	1.6
Intelligence (Savage-Jansen 2018)	0.7	2.1	2.2	1.5	1.4	1.4
Crohns Disease (2012)	0.7	1.1	2.3	-0.6	-0.9	-1.5
Lung FEV1/FVC ratio	0.7	3.6	8.9	-3.0	-1.4	0.3
Chronotype (morning person)	0.7	1.5	3.7	-0.7	-1.9	-0.6
Number of treatments/medications taken	0.7	1.2	2.0	1.4	0.1	1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.3	-1.0	-1.1	0.8
Qualifications: CSEs or equivalent	0.7	0.9	2.4	0.3	-1.6	0.5
Nervous feelings	0.7	1.3	3.4	-1.8	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.4	-0.9	1.1	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.3	-0.6	-0.7	-1.5
Birth weight of first child	0.7	1.2	2.0	-1.2	-0.3	-1.4
Pulse wave reflection index	0.7	0.9	1.4	-1.2	0.5	-1.0
Worry too long after embarrassment	0.7	1.1	2.6	-0.1	-0.9	-1.6
Medication: Ibuprofen	0.7	0.9	1.5	-1.2	0.4	-1.0
Overall health rating	0.7	1.6	3.6	-1.0	-1.9	-0.2
Family relationship satisfaction	0.7	0.9	2.7	0.2	1.6	0.2
Medication: Aspirin	0.7	0.9	2.6	0.1	0.2	1.6
Smoking status: Previous	0.7	1.1	2.6	0.5	1.6	0.5
Mood swings	0.7	1.3	2.1	-1.5	-0.8	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.1	1.5	0.0	0.0
Mother’s age at death	0.7	0.9	1.4	-0.7	0.9	1.2
Reaction Time	0.6	1.1	2.7	0.1	1.6	0.7
Breast Cancer	0.6	1.4	3.0	-0.8	-0.7	-1.7
Ovarian Cancer	0.6	0.8	1.1	0.6	1.0	-1.0
Lung FVC	0.6	3.1	6.6	-0.4	2.6	-1.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.7	1.3	-0.2	-0.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.6	-0.6	0.3	-1.3
Medication: Metformin	0.6	0.9	2.3	-0.1	-0.5	-1.5
Severe depression (siblings)	0.6	0.6	1.2	0.2	-0.9	-1.1
Fed-up feelings	0.6	1.1	2.1	-1.5	-0.8	-0.7
Age when periods started (menarche)	0.6	1.6	1.9	-1.1	-1.3	-1.4
Multivitamins +/- minerals	0.6	0.7	1.3	0.6	0.8	1.1
Sitting height	0.6	4.1	12.1	0.0	3.5	-0.4
Pain all over the body in last month	0.6	0.6	1.3	0.7	-1.1	0.0
Neuroticism score	0.6	1.3	2.3	-1.5	-0.7	-1.1
Time employed in main current job	0.6	0.7	1.2	-0.1	-0.9	-1.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.4	-0.2	1.8	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.4	-1.2	0.6	-0.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.7	-1.3	-0.6	0.3
High blood pressure (siblings)	0.6	0.8	2.0	0.3	0.6	1.4
Number of children fathered	0.6	0.7	1.1	0.2	1.0	1.1
Health satisfaction	0.6	0.8	1.5	1.2	-0.5	0.8
Medication: Allopurinol	0.6	0.8	1.5	-0.8	-1.2	0.3
Pulse rate, automated reading	0.6	2.0	3.4	0.8	1.4	1.8
Loneliness, isolation	0.6	0.8	2.0	0.6	0.1	1.4
Medication: Aspirin	0.6	0.8	2.4	-0.2	0.2	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.4	-0.1	0.5	-1.8
Illnesses of father: High blood pressure	0.6	0.8	1.2	1.1	0.2	-1.1
Age started oral contraceptive pill	0.6	0.7	1.2	-0.7	1.1	0.7
Diastolic blood pressure, automated reading	0.6	1.9	3.6	1.0	1.9	1.1
Unable to work because of sickness or disability	0.6	0.7	2.1	0.0	-0.4	-1.4
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.3	-1.1	-0.4	0.9
Bipolar Disorder or Schizophrenia	0.5	1.3	2.1	1.5	1.0	0.9
Schizophrenia (2018)	0.5	1.0	2.0	1.4	0.5	0.9
Schizophrenia vs Biploar Disorder	0.5	0.6	1.0	-1.0	-0.8	0.5
Ulcerative Colitis (UC)	0.5	0.9	1.7	-0.2	-1.3	-1.0
HbA1C	0.5	0.6	1.0	-0.6	0.7	1.0
Diabetes (father)	0.5	0.7	0.8	-0.9	0.8	-0.7
Average weekly fortified wine intake	0.5	0.6	1.5	0.5	1.2	0.3
Serious illness, injury or assault to yourself	0.5	0.6	0.9	0.9	-0.9	0.3
Medication: Atenolol	0.5	0.6	1.0	-0.8	-0.5	1.0
Impedance of leg (left)	0.5	2.6	5.0	0.8	1.4	2.2
Had other major operations	0.5	0.6	1.4	-0.6	-0.5	-1.2
Heart attack	0.5	0.7	1.1	-0.9	-0.4	1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	1.3	0.5	-0.5
Prospective memory result	0.5	0.6	1.6	-1.3	0.3	0.2
Medication: Amlodipine	0.5	0.7	0.9	-0.7	-0.9	-1.0
Age at first live birth	0.5	1.0	2.4	-1.5	0.7	0.3
Medication: Omeprazole	0.5	0.6	1.6	0.3	0.3	1.2
Alcohol intake frequency.	0.5	1.2	3.1	-1.8	-0.7	-0.1
Number of full sisters	0.5	0.6	0.8	0.9	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.8	-0.4	0.4	-1.7
Medication: Paracetamol	0.5	0.7	1.6	1.3	-0.5	-0.6
Number of operations (self-reported)	0.5	0.7	1.9	-1.4	0.4	-0.1
Irritability	0.5	0.9	1.7	-1.3	1.1	-0.1
Risk taking	0.5	0.7	1.3	-0.1	1.1	0.8
Major Depression (MDD)	0.4	0.5	1.4	-0.2	-0.4	-1.2
Height	0.4	7.5	16.8	1.8	4.1	1.6
Angina	0.4	0.6	0.8	0.4	0.9	0.9
Stomach or abdominal pain in last month	0.4	0.5	1.5	-0.3	0.0	1.2
High blood pressure (mother)	0.4	0.6	1.1	0.3	1.1	0.7
Number of incorrect matches in round	0.4	0.7	1.9	-0.4	-1.4	-0.3
Past tobacco smoking	0.4	0.8	2.0	-0.5	-1.4	-0.1
Qualifications: None of the above	0.4	0.9	1.9	-0.5	-1.4	-0.7
Allergy	0.4	1.0	1.9	-1.4	0.9	0.4
Father’s age at death	0.4	0.5	0.9	0.4	-1.0	0.7
Length of working week for main job	0.4	0.4	1.0	0.4	1.0	-0.3
Hair/balding pattern: Pattern 4	0.4	0.9	1.1	-1.0	-0.6	-1.1
Leg fat percentage (right)	0.4	1.5	4.0	2.0	0.6	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.0	0.5	-1.0	0.3
Shortness of breath walking on level ground	0.4	0.5	1.2	-0.3	-0.3	1.1
Angina (self-reported)	0.4	0.6	1.0	0.3	0.8	1.0
Leg fat-free mass (right)	0.4	2.0	5.5	-0.7	-0.3	-2.3
Arm fat percentage (left)	0.4	1.6	3.1	1.8	0.1	-1.3
Leg predicted mass (right)	0.4	2.0	5.4	-0.7	-0.3	-2.3
Financial situation satisfaction	0.4	0.5	0.7	-0.6	-0.8	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	0.3	-0.2	1.2
Ever depressed for a whole week	0.4	0.5	1.0	0.6	0.4	1.0
Commuting to job workplace: Cycle	0.4	0.5	0.8	-0.0	0.8	0.9
Bipolar Disorder (2018)	0.3	0.5	1.1	0.6	1.0	0.3
Neuroticism (Nagel 2018)	0.3	0.6	0.9	-0.9	-0.2	-1.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	0.2	-1.0	-0.3
Schizophrenia (2014)	0.3	0.8	1.2	1.1	0.8	0.6
Systolic Blood Pressure	0.3	1.4	2.3	0.4	1.2	1.5
Allergy or Eczema	0.3	0.7	1.5	1.2	0.2	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	0.6	1.0	0.2
Diabetes (mother)	0.3	0.4	0.7	-0.5	0.8	0.3
Leg fat-free mass (left)	0.3	1.3	4.0	-0.2	0.1	-2.0
Trunk fat percentage	0.3	1.4	2.5	1.6	0.2	-1.2
Hand grip strength (right)	0.3	0.8	1.3	-0.4	1.1	-1.0
Leg predicted mass (left)	0.3	1.4	4.3	-0.2	0.1	-2.1
Trunk fat mass	0.3	1.3	2.2	1.5	0.5	-1.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.4	0.6	0.6	0.6
Illnesses of siblings	0.3	0.4	0.7	0.8	0.3	-0.7
Arm fat percentage (right)	0.3	1.4	2.7	1.7	0.2	-1.2
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.3	1.0	1.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	0.6	0.8	-0.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	-0.2	1.0	0.2
Arm fat mass (right)	0.3	1.1	2.1	1.5	0.5	-1.0
Medication: Paracetamol	0.3	0.5	0.6	0.8	-0.7	-0.7
Body fat percentage	0.3	1.4	3.3	1.8	0.3	-0.8
Pulse wave peak to peak time	0.3	0.4	1.1	0.1	-1.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	-0.2	-0.8	-0.7
Emphysema/chronic bronchitis	0.3	0.3	0.9	-0.3	-0.1	-0.9
Migraine (self-reported)	0.3	0.3	1.0	-0.1	-0.0	-1.0
Whole body fat mass	0.3	1.2	2.4	1.6	0.6	-0.9
Leg fat mass (right)	0.3	1.1	2.7	1.6	0.8	-0.1
Comparative height size at age 10	0.3	1.5	2.3	-1.5	0.1	-1.4
Chest pain or discomfort	0.3	0.4	1.1	0.3	1.0	0.2
Age at last live birth	0.3	0.5	0.7	-0.8	0.7	-0.4
Hypertension (Self-reported)	0.3	0.7	1.4	-0.2	0.8	1.2
Average weekly red wine intake	0.3	0.4	0.8	-0.1	0.6	0.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	-0.1	1.1	-0.3
Ever taken oral contraceptive pill	0.3	0.4	0.7	0.8	-0.2	-0.7
Ever smoked	0.3	0.6	1.4	0.4	1.2	-0.4
Leg fat percentage (left)	0.3	1.0	2.7	1.6	0.5	0.2
Supplements: Calcium	0.3	0.3	0.6	-0.0	0.5	0.8
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.7	-0.0	0.8
Prostate Cancer	0.2	0.3	0.7	0.4	-0.8	-0.1
Blood White Count	0.2	1.5	2.9	1.3	-1.7	-0.1
Neuroticism	0.2	0.4	1.2	-0.1	0.1	-1.1
Hand grip strength (left)	0.2	0.5	0.7	-0.8	0.7	-0.7
Supplements: Zinc	0.2	0.2	0.3	0.5	0.2	0.5
Pack years adult smoking proportion	0.2	0.3	0.8	-0.0	-0.3	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	0.1	0.2	-0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	-0.2	-0.8	0.5
Medication: Levothyroxine sodium	0.2	0.4	0.6	-0.6	-0.4	-0.8
Waist circumference	0.2	0.8	1.4	0.8	-0.5	-1.2
Alcohol usually taken with meals	0.2	0.2	0.7	-0.1	-0.2	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.3	0.6	0.4	0.4
Impedance of arm (right)	0.2	0.8	1.8	1.3	0.7	-0.1
Hip circumference	0.2	0.9	1.4	1.0	-0.4	-1.2
Impedance of arm (left)	0.2	0.7	2.0	1.4	0.2	-0.3
Standing height	0.2	2.0	6.1	-0.0	2.5	0.1
Blood clot in the leg (DVT)	0.2	0.3	0.5	0.4	0.5	0.7
Gout (self-reported)	0.2	0.3	0.6	-0.4	-0.2	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-0.3	-1.0	-0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.4	-0.6	-0.3	-0.7
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.1	0.9	-0.3
Heart disease (mother)	0.2	0.2	0.4	-0.2	-0.6	-0.4
Had major operations	0.2	0.3	0.7	-0.8	-0.3	-0.2
Supplements: Vitamin C	0.2	0.2	0.5	0.0	0.1	0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.9	0.9	-0.1	0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	0.9	0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	-0.8	-0.3	0.0
Osteoporosis (self-reported)	0.2	0.3	0.5	-0.7	0.4	0.5
Arm fat mass (left)	0.2	0.9	1.7	1.3	0.4	-0.9
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.1	0.7	0.0	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	-0.1	-0.2	0.9
Pain experienced in last month	0.2	0.3	0.4	0.5	-0.6	-0.6
Pack years of smoking	0.2	0.3	0.9	-0.0	-0.3	1.0
Leg fat mass (left)	0.2	0.8	1.8	1.4	0.8	-0.2
Depression (Nagel 2018)	0.1	0.1	0.3	0.1	-0.3	0.5
Worry (Nagel 2018)	0.1	0.3	0.8	-0.9	0.1	-0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.3	0.1	0.5
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.4	0.1	0.4
BMI	0.1	0.3	0.9	0.9	-0.0	-0.2
Waist Hip Ratio (WHR)	0.1	0.3	0.5	0.2	-0.6	-0.7
Smoking Status	0.1	0.1	0.2	0.4	0.3	-0.4
Hypothyroidism (self reported)	0.1	0.2	0.6	0.2	-0.8	-0.3
Tanning	0.1	1.5	2.8	0.2	-1.7	-1.3
Relative age of first facial hair	0.1	0.3	0.8	-0.1	0.9	-0.1
Current tobacco smoking	0.1	0.1	0.3	0.2	-0.3	-0.5
High blood pressure	0.1	0.2	0.3	-0.4	0.2	0.6
Body mass index (BMI)	0.1	0.5	1.0	1.0	-0.4	-0.7
Weight	0.1	0.6	0.7	0.8	0.6	-0.8
Trunk fat-free mass	0.1	0.6	1.6	-0.3	1.3	-0.1
Number of live births	0.1	0.2	0.5	0.1	-0.7	-0.3
Depression (self-reported)	0.1	0.1	0.2	-0.4	0.4	-0.0
Trunk predicted mass	0.1	0.5	1.4	-0.5	1.2	-0.2
Exposure to tobacco smoke at home	0.1	0.2	0.4	-0.7	-0.2	-0.0
Peak expiratory flow (PEF)	0.1	0.1	0.4	0.2	0.2	-0.6
Birth weight	0.1	0.3	0.4	-0.6	0.6	0.2
Arm fat-free mass (right)	0.1	0.3	0.5	-0.2	0.7	-0.7
Exposure to tobacco smoke outside home	0.1	0.2	0.3	0.4	-0.6	-0.2
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	0.0	0.3	-0.6
Medication: Blood pressure	0.1	0.1	0.3	-0.2	-0.5	-0.2
Arm predicted mass (right)	0.1	0.3	0.4	-0.5	0.6	-0.5
Whole body fat-free mass	0.1	0.6	0.9	-0.4	0.8	-0.9
Breast cancer (self-reported)	0.1	0.2	0.4	-0.2	0.0	0.6
Smoking status: Current	0.1	0.2	0.2	0.5	-0.5	-0.3
Whole body water mass	0.1	0.6	1.0	-0.4	0.7	-1.0
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	0.3	-0.3	0.6
Wears glasses or contact lenses	0.1	0.1	0.2	-0.1	-0.2	0.5
Alcohol drinker status: Never	0.1	0.1	0.1	-0.3	0.3	0.2
Basal metabolic rate	0.1	0.5	0.9	-0.1	0.7	-0.9
Arm fat-free mass (left)	0.1	0.3	0.5	-0.5	0.7	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.5	-0.4	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.0	0.3	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	-0.2	0.1	0.6
Heart disease (siblings)	0.1	0.2	0.2	-0.5	-0.4	0.4
Impedance of whole body	0.1	0.7	1.4	1.2	0.7	0.6
Arm predicted mass (left)	0.1	0.4	1.0	-0.3	1.0	-0.2
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.3	0.1	-0.0
Age at First Birth	0.0	0.1	0.1	-0.1	0.2	0.4
Bipolar Disorder (2011)	0.0	0.0	0.1	0.2	0.1	0.0
Blood Red Count	0.0	0.4	1.1	-0.4	-1.1	-0.3
Hair Pigment	0.0	0.3	0.3	0.5	0.5	0.6
Relative age voice broke	0.0	0.1	0.1	0.2	0.0	0.3
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	0.2	0.1	0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.1	0.2	-0.2
Knee pain experienced in last month	0.0	0.1	0.1	-0.2	-0.1	0.4

Hub : Genes

CYP26A1

Models

Trait associations