Hub : Genes

DNM1L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1340	0.0440	3.8e-06	0.015	NA	0.062	NA	0.067	2.4e-02	NA	2.1e-05	NA	9.3e-06
2	GTEx	Testis	0.1310	0.0470	6.0e-04	0.136	NA	0.092	NA	0.121	1.3e-06	NA	7.2e-05	NA	5.1e-06
3	YFS	Blood	0.0576	0.0146	1.1e-15	0.063	0.055	0.059	0.057	0.063	8.7e-20	2.4e-17	1.4e-18	4.3e-18	6.8e-20
4	TCGA	Glioblastoma Multiforme	0.1030	0.0600	6.3e-03	0.011	0.051	0.021	NA	0.026	1.5e-01	1.1e-02	7.6e-02	NA	5.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	1.4	-0.4	1.2	-1.0	0.8
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.6	0.1	-0.2	-0.3
Depressed Affect (Nagel 2018)	1.2	2.6	5.1	-0.4	-1.9	1.2	-2.3
Depression (Nagel 2018)	0.4	0.6	1.0	-1.0	-0.5	0.6	-0.8
Intelligence (Savage-Jansen 2018)	1.5	4.5	9.4	2.2	2.0	-0.2	3.1
Neuroticism (Nagel 2018)	1.4	3.2	5.9	-1.4	-2.0	1.0	-2.4
Schizophrenia (2018)	0.3	0.6	1.1	-0.4	-0.8	0.6	-1.0
Schizophrenia vs Biploar Disorder	2.1	2.8	5.3	2.3	1.5	-0.3	1.9
Worry (Nagel 2018)	1.0	2.1	2.8	-1.3	-1.7	1.1	-1.6
Alzheimer’s Disease (in mother)	0.6	0.7	2.0	0.3	1.4	-0.1	0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.6	0.5	0.5	0.4
Alzheimer’s Disease (including proxy)	0.5	0.8	2.1	-0.1	1.5	0.2	0.9
Crohns Disease (2017)	0.5	1.0	1.6	0.9	1.3	-0.2	1.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	0.8	0.2	-0.3	0.1
Ulcerative Colitis (UC)	0.3	0.5	1.1	-0.0	-1.1	0.1	-1.0
Major Depression (MDD)	1.5	1.9	2.3	-1.3	-1.5	1.2	-1.5
Reaction Time	0.1	0.2	0.7	-0.0	0.1	-0.8	-0.3
Verbal and Numeric Reasoning (VNR)	1.1	2.5	5.7	2.4	1.1	-0.1	1.8
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.0	0.0	0.0	0.0	0.1	-0.0	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.2	3.2	4.3	1.6	1.7	-2.1	1.8
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.2	-0.5	-0.5	-0.3
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	-0.2	0.6	0.4	0.6
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.3	0.2	0.0	0.1
Crohns Disease (2012)	0.4	0.6	1.1	-0.7	0.6	1.0	0.8
Mean Putamen Volume	0.2	0.3	0.5	-0.4	-0.7	0.1	-0.6
Fasting Glucose	0.2	0.2	0.4	0.6	-0.5	-0.2	-0.3
HbA1C	0.3	0.4	0.5	-0.7	-0.7	0.2	-0.7
HDL Cholesterol	1.8	2.9	4.6	2.1	1.3	-1.7	1.5
LDL Cholesterol	0.6	0.9	1.3	-1.0	-1.1	1.0	-0.7
Lupus	0.3	0.5	1.3	-0.4	-0.5	1.2	-0.3
Neuroticism (2016)	1.9	2.8	4.8	-1.2	-2.2	0.6	-2.1
Primary Biliary Cirrhosis	0.2	0.3	0.6	-0.7	-0.4	0.8	-0.3
Rheumatoid Arthritis	1.4	2.0	3.1	-1.5	-1.3	0.8	-1.8
Schizophrenia (2014)	0.1	0.1	0.3	0.2	0.3	-0.6	0.3
Triglycerides	1.7	2.8	3.9	-1.7	-1.8	1.1	-2.0
Type 2 Diabetes (T2D) (2012)	0.7	0.9	1.2	-1.1	-1.1	1.0	-0.3
Ulcerative Colitis	0.1	0.2	0.4	-0.1	-0.5	0.6	-0.4
Blood Eosinophil Count	0.6	4.5	6.1	-1.5	-2.5	1.9	-2.4
Blood Platelet Count	3.9	45.5	63.8	-5.3	-8.0	5.7	-7.6
Blood Red Count	0.3	2.8	6.0	-2.4	-1.4	1.4	-1.1
Blood White Count	0.6	4.3	7.6	-1.0	-2.8	1.6	-2.4
Heel T-Score	0.0	0.3	0.9	0.0	0.1	-0.9	-0.5
BMI	0.2	1.4	4.8	-2.2	0.1	0.3	-0.8
Height	0.0	0.9	2.3	-0.1	0.7	-1.5	0.9
Waist Hip Ratio (WHR)	0.3	1.4	3.3	1.1	-1.0	1.8	0.2
Systolic Blood Pressure	0.9	4.7	8.8	-2.3	-1.8	3.0	-1.1
Smoking Status	0.2	0.4	0.7	0.8	-0.1	-0.9	0.1
Allergy or Eczema	1.0	2.7	4.8	1.9	1.6	-0.4	2.2
Cardiovascular Disease	1.0	3.4	4.8	-1.5	-1.8	1.8	-2.2
Hypothyroidism (self reported)	0.1	0.2	0.3	0.3	0.5	-0.3	0.4
Respiratory disease	0.1	0.1	0.3	0.6	-0.2	0.1	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.4	-0.0	0.3	-0.2	0.6
Lung FEV1/FVC ratio	0.2	1.0	1.1	0.9	1.0	-1.1	0.9
Lung FVC	0.1	0.7	1.6	0.1	-1.3	0.5	-0.9
Neuroticism	1.0	2.5	4.6	-1.2	-2.0	0.5	-2.1
Chronotype (morning person)	0.1	0.2	0.5	-0.3	-0.1	-0.3	-0.7
Hair Pigment	0.1	1.6	3.7	1.9	0.8	-1.2	0.7
Tanning	0.0	0.2	0.7	0.3	0.3	-0.8	0.1
Hand grip strength (left)	0.2	0.5	1.0	1.0	-0.5	0.8	0.4
Number of treatments/medications taken	0.9	1.5	2.2	-1.0	-1.4	1.0	-1.5
Average weekly spirits intake	0.2	0.3	0.7	-0.7	-0.1	-0.1	-0.9
Sensitivity / hurt feelings	2.3	4.0	5.7	-1.8	-2.1	1.5	-2.4
Frequency of depressed mood in last 2 weeks	1.9	2.7	3.4	-1.3	-1.5	1.8	-1.8
Hearing difficulty/problems: Yes	0.7	1.0	3.0	0.2	0.0	-1.7	-1.0
Relative age of first facial hair	0.5	0.9	3.2	1.8	0.3	-0.3	0.6
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	4.3	2.1	0.9	-1.3	1.0
Ever used hormone-replacement therapy (HRT)	0.9	1.2	1.9	0.0	-1.3	1.4	-1.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.2	0.2	-0.8	0.3
Systolic blood pressure, automated reading	1.0	2.8	5.0	-2.2	-1.1	2.2	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.8	-0.4	0.8	-0.3
Angina	0.6	0.7	1.5	-0.4	-0.9	0.6	-1.2
Medication for hormone replacement therapy	0.2	0.2	0.6	0.5	0.3	-0.8	-0.2
Vitamin and mineral supplements	0.2	0.3	0.9	0.2	-0.6	-0.0	-0.9
Supplements: Zinc	0.6	0.7	1.2	-0.7	-1.1	-0.2	-1.0
Medication: Co-codamol	1.8	2.1	3.1	-1.8	-1.0	1.4	-1.5
Medication: Metformin	0.4	0.6	1.3	-0.8	-0.7	1.1	0.2
Diabetes (father)	0.4	0.5	1.1	-1.1	-0.4	0.2	-0.9
Diabetes (mother)	0.0	0.0	0.0	-0.0	-0.2	-0.1	0.0
Severe depression (siblings)	0.1	0.2	0.3	-0.5	0.1	0.6	0.3
Pack years adult smoking proportion	0.0	0.1	0.1	-0.3	0.2	-0.4	-0.2
Impedance of leg (right)	0.1	0.3	0.9	1.0	0.1	0.2	0.6
Leg fat-free mass (left)	0.2	1.2	4.4	-2.1	0.0	0.5	-0.5
Trunk fat percentage	1.0	4.0	8.9	-3.0	-1.2	2.1	-1.2
Hand grip strength (right)	0.3	0.7	1.4	0.9	0.2	0.8	1.2
Townsend deprivation index at recruitment	5.1	7.2	9.6	-3.1	-2.4	2.5	-2.7
Current tobacco smoking	0.2	0.4	1.0	-0.0	-1.0	0.0	-0.8
Average weekly fortified wine intake	0.4	0.5	0.7	0.8	-0.5	-0.5	-0.9
Maternal smoking around birth	0.2	0.3	0.6	0.8	-0.6	0.0	-0.4
Fed-up feelings	0.4	0.7	1.3	0.5	-0.8	0.7	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	-0.4	-0.6	0.6	-1.1
Relative age voice broke	0.1	0.2	0.5	0.1	0.2	0.7	0.6
Taking other prescription medications	0.6	1.0	2.8	-0.5	-0.9	-0.3	-1.7
Age when periods started (menarche)	0.7	1.7	3.4	1.8	1.1	-1.0	1.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.5	0.5	-0.7	0.7	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.3	1.5	1.1	-1.0	0.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.5	-0.1	1.0	-1.6	0.6
Qualifications: CSEs or equivalent	0.9	1.2	2.5	-1.6	-0.9	0.1	-1.2
Serious illness, injury or assault to yourself	1.9	2.3	3.0	1.4	1.7	-1.3	1.6
High blood pressure	0.1	0.3	0.5	-0.7	-0.4	0.4	-0.6
Hayfever, allergic rhinitis or eczema	1.0	2.2	3.6	1.7	1.4	-0.3	1.9
Multivitamins +/- minerals	0.4	0.5	1.2	-1.1	-0.1	0.8	0.1
Stomach or abdominal pain in last month	0.3	0.3	0.5	0.7	0.6	-0.7	0.2
Supplements: Glucosamine	0.3	0.4	0.6	-0.6	-0.7	-0.4	-0.8
Diverticular disease/diverticulitis (self-reported)	3.5	4.1	5.6	1.9	2.3	-1.5	2.4
Medication: Atenolol	0.1	0.1	0.1	-0.4	-0.3	-0.3	-0.2
Medication: Levothyroxine sodium	0.0	0.0	0.0	0.1	0.2	-0.2	-0.2
Sitting height	0.1	0.8	2.6	-1.6	-0.4	-0.4	-0.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	-0.3	0.8	-0.1	0.7
High blood pressure (mother)	2.6	3.6	4.8	2.0	1.9	-1.5	2.2
Body mass index (BMI)	0.8	3.4	8.2	-2.9	-0.8	1.6	-1.4
Impedance of leg (left)	0.1	0.3	0.9	0.9	-0.2	0.3	0.5
Leg predicted mass (left)	0.2	1.3	4.7	-2.2	-0.0	0.5	-0.6
Trunk fat mass	0.8	3.4	8.5	-2.9	-0.9	1.7	-1.1
Waist circumference	0.9	3.2	5.6	-2.4	-1.2	2.0	-1.4
Number of incorrect matches in round	0.5	0.8	2.3	0.7	0.6	-1.5	-0.0
Past tobacco smoking	0.0	0.0	0.2	-0.4	0.0	0.0	0.1
Alcohol usually taken with meals	1.5	2.4	4.8	1.3	1.3	-2.2	1.2
Nervous feelings	2.7	5.1	6.9	-2.6	-2.2	1.9	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.5	0.3	0.2	-0.3
Hearing difficulty/problems with background noise	1.0	1.6	3.0	1.7	0.7	-1.7	-0.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.2	1.1	0.2	-0.3	0.6
Had menopause	1.2	1.5	3.1	-1.8	-1.1	1.1	-0.8
Had other major operations	0.4	0.5	1.0	-0.8	0.0	1.0	0.3
Forced vital capacity (FVC)	0.3	1.1	1.4	1.0	0.9	-1.1	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	0.5	0.9	-1.0	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	-0.3	-0.6	0.8	-0.8
Qualifications: None of the above	1.6	3.4	5.2	-2.3	-1.4	1.8	-1.8
Financial difficulties in last 2 years	0.6	0.7	2.4	1.6	0.5	-0.6	-0.1
Mouth/teeth dental problems	0.9	1.3	2.5	0.8	1.3	-0.8	1.6
Heart attack	1.7	2.2	2.4	-1.5	-1.6	1.3	-1.6
Allergy	0.1	0.2	0.6	-0.8	-0.3	-0.2	-0.2
Pain all over the body in last month	1.1	1.1	2.5	-1.2	-0.5	1.6	-0.4
Diabetes (self-reported)	0.1	0.1	0.3	0.1	-0.1	0.5	0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	-0.3	-0.9	0.9	-0.4
Medication: Ramipril	0.3	0.4	0.7	-0.6	-0.9	0.2	-0.5
Medication: Simvastatin	2.8	4.1	5.2	-2.3	-2.1	1.8	-2.0
Fluid intelligence score	0.7	1.5	3.5	1.9	0.7	0.5	1.3
Illnesses of siblings	0.1	0.2	0.3	-0.6	-0.1	0.5	-0.3
Neuroticism score	2.2	4.5	7.8	-1.1	-2.7	1.4	-2.8
Weight	0.6	3.1	9.2	-3.0	-0.6	1.2	-1.2
Impedance of arm (right)	0.1	0.5	1.4	1.2	0.1	-0.2	0.8
Arm fat percentage (right)	0.9	3.5	7.4	-2.7	-0.9	1.9	-1.4
Trunk fat-free mass	0.1	0.7	2.4	-1.6	0.3	0.2	-0.3
Hip circumference	0.9	4.0	10.1	-3.2	-0.9	1.4	-1.8
Time employed in main current job	0.5	0.6	2.1	-1.5	-0.2	-0.1	-0.4
Alcohol intake versus 10 years previously	1.8	2.8	4.9	-2.2	-1.5	1.4	-1.4
Father’s age at death	0.2	0.2	0.7	-0.2	-0.4	-0.0	-0.8
Worrier / anxious feelings	0.3	0.6	1.2	-0.0	-1.1	0.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.2	-0.3	0.6	-0.7
Falls in the last year	1.1	1.5	2.7	0.8	1.7	-0.7	1.4
Hair/balding pattern: Pattern 3	0.4	0.7	1.4	-0.8	0.6	-1.2	-0.5
Number of live births	0.1	0.2	0.5	-0.7	-0.2	0.3	-0.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	2.9	1.5	1.4	-1.4	1.7
Pulse rate	2.5	4.3	8.4	1.3	2.4	-2.9	1.1
Happiness	0.5	0.6	1.1	0.9	0.6	-1.0	0.3
Noisy workplace	0.9	1.1	2.4	-0.8	-1.1	0.3	-1.6
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.7	0.4	-0.9	-0.4	-0.5
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	3.4	-1.8	-1.4	1.6	-1.5
Mouth/teeth dental problems: Dentures	0.8	1.3	1.8	-0.5	-1.3	1.2	-1.3
Asthma	0.0	0.1	0.2	0.1	-0.1	-0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.0	0.2	-1.4	0.4	-1.4
Medication: Cholesterol lowering	2.6	4.0	5.4	-1.6	-2.3	1.9	-2.1
Depression (self-reported)	0.2	0.2	0.5	0.7	0.5	0.3	0.3
Medication: Lansoprazole	0.3	0.3	1.2	-1.1	-0.1	-0.1	-0.3
Prospective memory result	1.9	2.3	4.1	-2.0	-1.0	-0.7	-1.9
Lung cancer (father)	2.4	2.8	3.3	-1.5	-1.8	1.7	-1.6
Illnesses of mother	1.8	2.2	2.8	-0.9	-1.6	1.7	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.4	1.0	1.1	-1.6	1.2
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.5	-0.2	-0.9	-0.6
Impedance of arm (left)	0.1	0.5	1.0	1.0	0.1	-0.1	0.9
Arm fat mass (right)	1.1	4.4	10.3	-3.2	-1.0	1.9	-1.5
Trunk predicted mass	0.1	0.6	2.3	-1.5	0.3	0.2	-0.3
Standing height	0.0	0.3	0.6	-0.8	0.3	-0.6	0.3
Length of working week for main job	3.2	3.6	6.2	1.3	1.8	-2.5	1.8
Exposure to tobacco smoke at home	1.2	1.3	3.1	-1.8	-0.7	0.3	-1.3
Breastfed as a baby	0.7	0.8	3.1	-0.1	0.3	-1.8	-0.0
Tense / ‘highly strung’	0.1	0.2	0.4	0.6	0.5	-0.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	3.8	5.9	8.7	-0.7	-3.0	2.4	-2.9
Hair/balding pattern: Pattern 4	1.8	4.3	9.4	-1.9	-1.6	3.1	-1.2
Birth weight of first child	0.1	0.1	0.3	0.6	-0.3	0.3	0.1
Peak expiratory flow (PEF)	0.5	1.1	2.8	0.3	1.1	-0.5	1.7
Pulse wave reflection index	0.4	0.5	1.0	-0.5	-0.9	0.3	-1.0
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.7	-0.3	-0.1	-0.5
Loud music exposure frequency	0.4	0.4	0.6	0.8	0.7	-0.1	0.7
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	2.9	1.4	1.2	-1.5	1.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	1.9	-1.4	-1.1	0.7	-1.1
Blood clot in the leg (DVT)	0.0	0.1	0.1	0.4	-0.0	0.3	0.0
Medication: Paracetamol	0.3	0.4	1.7	1.3	0.1	0.3	-0.1
Headache pain in last month	0.2	0.4	1.4	1.2	-0.0	0.4	0.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	1.6	1.1	1.2	-1.3	1.0
Glaucoma (self-reported)	0.3	0.4	0.9	0.9	-0.2	-0.7	0.2
Gout (self-reported)	1.9	2.6	3.6	1.6	1.4	-1.9	1.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.4	-0.4	0.0	-0.6
Medication: Amlodipine	0.1	0.1	0.5	0.1	0.3	0.0	0.7
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.2	0.4	-0.5	0.1
Birth weight	0.1	0.3	0.8	0.9	-0.2	0.4	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.5	0.5	-0.3	0.1
High blood pressure (siblings)	0.7	1.0	1.4	1.0	1.0	-1.2	0.8
Forced vital capacity (FVC), Best measure	0.1	0.4	1.1	0.3	0.4	-1.1	0.4
Body fat percentage	0.9	3.4	7.6	-2.8	-0.9	1.9	-1.2
Leg fat percentage (right)	0.7	2.5	5.4	-2.3	-0.6	1.7	-1.1
Arm fat-free mass (right)	0.3	1.7	5.4	-2.3	-0.2	0.9	-0.7
Exposure to tobacco smoke outside home	0.1	0.2	0.6	-0.3	-0.0	0.1	-0.8
Comparative body size at age 10	0.1	0.3	0.8	-0.9	0.3	-0.1	-0.5
Number of full brothers	1.6	2.1	3.7	-0.9	-1.4	1.3	-1.9
Worry too long after embarrassment	0.3	0.4	0.9	0.4	-0.3	-0.9	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.7	-0.5	-1.6	0.9	-1.6
Wheeze or whistling in the chest in last year	1.0	1.7	2.4	-1.6	-0.9	1.5	-1.2
Number of children fathered	3.3	3.8	6.2	2.5	1.7	-0.9	2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.9	-0.5	0.0	0.1
Age at first live birth	2.6	4.6	7.3	2.7	1.9	-1.7	2.1
Pulse wave peak to peak time	0.3	0.4	0.9	-0.5	0.2	1.0	0.6
Health satisfaction	0.3	0.4	0.8	-0.6	-0.9	0.4	-0.6
Shortness of breath walking on level ground	0.6	0.7	1.2	0.4	0.8	-1.1	1.0
Qualifications: College or University degree	2.1	6.6	13.2	3.6	1.9	-1.5	2.7
Eye problems/disorders: None of the above	1.2	1.4	2.1	-1.1	-1.4	0.5	-1.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.5	0.2	0.2	0.4
Emphysema/chronic bronchitis	0.8	0.9	2.3	-0.6	-1.0	-0.2	-1.5
Medication for pain relief, constipation, heartburn	0.9	1.5	2.4	0.6	1.3	-1.5	1.3
Neck or shoulder pain in last month	0.6	0.8	2.0	0.5	0.9	-1.4	0.1
Medication: Blood pressure	0.5	0.9	2.3	-1.5	-0.6	0.8	-0.7
Angina (self-reported)	0.8	1.1	2.0	-0.6	-1.2	0.8	-1.4
Migraine (self-reported)	1.2	1.5	2.2	1.5	1.0	-0.9	1.3
Medication: Ibuprofen	1.3	1.6	3.1	-0.5	-1.6	0.7	-1.8
Medication: Allopurinol	1.6	2.1	3.0	1.7	1.2	-1.2	1.6
Medication: Omeprazole	0.2	0.3	0.6	-0.4	-0.4	0.5	-0.8
Medication: Seretide 50 evohaler	0.4	0.4	1.1	-0.4	-1.1	0.1	-0.6
Mean time to correctly identify matches	0.3	0.5	1.2	-0.5	-0.4	-1.1	-0.7
Heart disease (mother)	2.1	2.6	3.3	1.5	1.5	-1.8	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	4.1	1.6	1.7	-0.9	2.0
Whole body fat mass	0.8	3.3	8.5	-2.9	-0.7	1.7	-1.1
Leg fat mass (right)	0.7	2.6	6.7	-2.6	-0.5	1.5	-1.2
Arm predicted mass (right)	0.3	1.7	5.3	-2.3	-0.3	0.8	-0.8
Pulse rate, automated reading	0.7	2.2	4.7	1.0	2.2	-0.9	1.6
Alcohol intake frequency.	0.4	1.0	1.6	-1.1	-0.6	1.3	-0.9
Comparative height size at age 10	0.1	0.4	0.7	-0.9	0.5	-0.2	0.8
Number of full sisters	2.2	2.7	3.7	-1.5	-1.6	1.5	-1.9
Suffer from ‘nerves’	3.8	5.9	7.6	-2.3	-2.8	1.9	-2.7
Overall health rating	0.3	0.7	1.7	-1.3	-0.3	1.0	-0.1
Chest pain or discomfort	0.2	0.3	0.8	0.9	0.4	-0.2	0.5
Had major operations	1.2	1.4	2.3	0.9	1.5	-0.6	1.4
Age at last live birth	1.3	1.9	3.3	1.8	1.1	-1.2	1.3
Family relationship satisfaction	0.8	1.0	1.9	1.1	0.9	-1.4	0.3
Leg pain on walking	0.6	0.7	1.1	0.0	1.0	-1.1	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.0	0.5	-0.0	0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	-0.1	-0.3	1.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.4	0.1	-0.4	0.3
Medication: Aspirin	0.1	0.2	0.3	-0.1	0.6	-0.2	0.6
Supplements: Vitamin C	0.1	0.1	0.4	0.2	0.2	-0.2	0.6
Knee pain experienced in last month	1.1	1.8	2.9	1.7	1.1	-1.6	0.6
Hypertension (Self-reported)	0.4	1.0	1.6	-1.2	-0.9	0.9	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	-0.3	0.3	-0.6	-0.5
Illnesses of father: Heart disease	1.1	1.5	2.5	-1.2	-1.3	0.5	-1.6
Illnesses of siblings: Diabetes	0.0	0.0	0.0	0.1	0.1	-0.1	0.1
Smoking status: Previous	0.3	0.5	0.7	0.4	0.8	-0.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.5	0.3	0.7	-0.6	0.7
Whole body fat-free mass	0.2	1.1	3.9	-2.0	0.0	0.4	-0.5
Leg fat-free mass (right)	0.2	1.2	4.1	-2.0	-0.1	0.4	-0.6
Arm fat percentage (left)	0.8	3.4	7.5	-2.7	-0.9	1.9	-1.3
Average weekly red wine intake	0.4	0.6	1.0	0.9	0.6	-1.0	0.5
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.1	0.8	1.1	-0.8	0.9
Mood swings	8.3	15.0	21.7	-2.6	-4.4	3.5	-4.7
Loneliness, isolation	1.5	2.1	2.5	-1.2	-1.6	1.5	-1.5
Long-standing illness, disability or infirmity	0.0	0.1	0.3	0.5	-0.1	0.1	0.1
Ever had bowel cancer screening	1.6	1.9	3.1	-1.3	-1.4	1.0	-1.8
Diabetes diagnosed by doctor	0.0	0.1	0.2	-0.2	-0.1	0.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.6	0.7	-0.6	0.1	-0.8
Friendships satisfaction	0.3	0.4	0.8	0.7	-0.1	-0.9	-0.3
Qualifications: nursing, teaching	1.2	1.9	3.2	1.6	0.8	-1.8	1.2
Commuting to job workplace: Walk	0.2	0.2	0.6	-0.8	-0.4	0.2	-0.1
Eye problems/disorders: Cataract	1.4	1.6	2.9	0.9	1.5	-0.5	1.7
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.9	1.2	0.1	-1.4	-0.6
Medication for cholesterol	1.8	2.7	4.5	0.9	2.1	-1.1	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	1.1	-0.0	-0.6	-0.6
Back pain experienced in last month	0.8	1.2	3.2	-0.9	-0.8	0.2	-1.8
Mineral and other dietary supplements	0.6	0.8	2.5	1.6	0.4	-0.7	0.6
Breast cancer (self-reported)	0.1	0.1	0.3	0.3	-0.3	0.5	-0.0
Asthma (self-reported)	0.1	0.1	0.5	0.1	0.3	-0.7	0.1
Osteoporosis (self-reported)	0.3	0.4	1.0	1.0	0.4	-0.4	0.3
Osteoarthritis (self-reported)	1.2	1.5	2.7	-0.9	-1.3	0.9	-1.6
Medication: Aspirin	0.1	0.2	0.3	-0.4	0.5	-0.3	0.5
Medication: Gliclazide	0.5	0.6	1.2	-0.5	-1.1	0.4	-0.9
Illnesses of father: None of the above (group 1)	3.4	4.2	8.9	3.0	1.6	-1.4	1.9
Smoking status: Current	0.2	0.3	0.6	0.3	-0.8	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	4.8	1.7	1.6	-2.2	1.4
Whole body water mass	0.2	1.2	4.0	-2.0	0.0	0.6	-0.5
Leg predicted mass (right)	0.2	1.1	3.8	-2.0	-0.0	0.4	-0.5
Arm fat mass (left)	1.0	4.1	9.5	-3.1	-1.0	2.0	-1.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.5	-0.2	-0.1	-0.3
Average weekly champagne plus white wine intake	2.1	2.9	4.2	-1.2	-1.7	2.0	-1.7
Miserableness	4.8	8.3	12.2	-1.4	-3.4	2.7	-3.5
Guilty feelings	0.1	0.2	0.3	0.5	-0.3	-0.2	-0.5
Wears glasses or contact lenses	1.0	1.1	1.2	1.1	1.1	-1.0	1.1
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.4	0.0	0.8	0.3
Hearing aid user	0.4	0.4	0.8	-0.9	-0.3	0.1	-0.9
Mother’s age at death	1.8	2.3	5.3	2.3	1.1	-1.2	1.1
Financial situation satisfaction	1.9	2.4	4.2	-0.6	-2.0	1.1	-1.9
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.3	0.3	-0.3	0.0
Commuting to job workplace: Public transport	1.3	1.5	2.8	1.1	1.2	-1.7	0.8
Eye problems/disorders: Glaucoma	0.7	0.8	1.7	1.3	0.3	-0.9	0.7
Medication: Blood pressure	0.7	1.4	2.6	-0.8	-1.6	0.4	-1.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	0.2	0.9	-0.1	0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.9	-1.4	-0.2	0.8	-0.2
High cholesterol (Self-reported)	3.2	5.6	9.2	-1.5	-3.0	1.8	-2.8
Medication: Bendroflumethiazide	2.3	3.5	4.6	-1.1	-2.1	2.1	-2.0
Medication: Paracetamol	0.1	0.2	0.4	0.7	0.4	-0.2	-0.0
Medication: Lisinopril	0.4	0.5	1.2	0.0	0.8	-1.1	0.5
Medication: Atorvastatin	1.4	1.8	3.5	-0.1	-1.9	1.5	-1.2
Illnesses of father: High blood pressure	1.2	1.5	2.3	-1.5	-1.0	1.1	-1.2
Alcohol drinker status: Never	0.8	0.9	2.1	1.5	0.8	-0.3	0.8
Ever smoked	0.4	0.6	1.1	-0.2	-1.0	0.7	-1.1
Basal metabolic rate	0.3	1.7	5.4	-2.3	-0.2	0.8	-0.7
Leg fat percentage (left)	0.8	2.7	5.8	-2.4	-0.7	1.8	-1.2
Arm fat-free mass (left)	0.5	2.6	6.9	-2.6	-0.7	1.3	-1.1
Number of operations (self-reported)	0.2	0.3	0.5	-0.2	0.6	0.7	0.5
Average weekly beer plus cider intake	0.0	0.1	0.2	0.2	0.1	0.2	0.4
Irritability	2.1	3.5	5.2	-1.4	-2.1	1.5	-2.3
Risk taking	1.2	1.7	5.4	2.3	0.7	-0.8	0.6
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.0	1.0	1.4	-0.4	1.7
Fractured/broken bones in last 5 years	0.8	1.1	1.5	1.2	0.9	-0.7	1.2
Age started oral contraceptive pill	0.1	0.1	0.2	-0.2	-0.1	0.2	0.5
Diastolic blood pressure, automated reading	0.6	1.9	3.1	-1.8	-0.6	1.8	-1.1
Ever depressed for a whole week	1.2	1.4	3.1	-0.5	-1.3	0.9	-1.8
Unable to work because of sickness or disability	0.8	1.1	3.6	-0.5	-0.6	1.9	-0.4
Commuting to job workplace: Cycle	0.6	0.8	2.1	1.4	0.0	-0.7	0.7
Myopia	3.0	4.4	5.2	-2.3	-2.1	1.9	-2.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.3	1.0	0.9	-0.7	1.1
Cholesterol lowering medication	2.4	3.6	4.5	-1.6	-2.1	1.9	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	0.0	0.4	-0.0	0.2
Pain experienced in last month	0.4	0.6	1.2	-0.8	-0.8	1.1	-0.1
Supplements: Calcium	0.2	0.2	0.3	-0.6	0.5	-0.4	0.4
Basal cell carcinoma (self-reported)	2.4	2.8	4.6	1.9	1.5	-0.9	2.1
Heart attack/myocardial infarction (self-reported)	2.3	2.9	3.3	-1.8	-1.8	1.5	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	0.0	-0.5	0.6	-0.3
Heart disease (siblings)	0.0	0.1	0.1	0.2	-0.3	0.1	-0.2
Alcohol drinker status: Previous	0.2	0.2	0.6	0.2	0.4	-0.2	0.8
Pack years of smoking	0.1	0.1	0.2	-0.2	0.4	-0.4	0.1
Impedance of whole body	0.1	0.5	1.2	1.1	0.0	-0.0	0.8
Leg fat mass (left)	0.7	2.9	7.2	-2.7	-0.6	1.6	-1.2
Arm predicted mass (left)	0.4	2.1	6.0	-2.5	-0.4	1.1	-0.9