TWAS hub - FGD4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1200	0.0280	8.4e-11	0.076	0.096	0.107	0.095	0.108	1.4e-09	1.1e-11	5.5e-13	1.3e-11	5.0e-13
2	GTEx	Brain Nucleus accumbens basal ganglia	0.2940	0.0910	1.6e-03	0.052	NA	0.046	NA	0.051	1.6e-02	NA	2.2e-02	NA	1.8e-02
3	GTEx	Esophagus Mucosa	0.1050	0.0440	8.3e-03	0.129	NA	0.111	NA	0.122	5.8e-09	NA	7.0e-08	NA	1.5e-08
4	GTEx	Heart Left Ventricle	0.1869	0.0649	4.0e-03	0.028	NA	0.046	NA	0.029	1.2e-02	NA	1.7e-03	NA	1.0e-02
5	GTEx	Lung	0.0824	0.0330	2.8e-03	0.050	NA	0.038	NA	0.025	1.1e-04	NA	6.4e-04	NA	4.6e-03
6	GTEx	Skin Sun Exposed Lower leg	0.1110	0.0420	2.5e-03	0.000	NA	0.017	NA	0.008	3.1e-01	NA	1.3e-02	NA	6.4e-02
7	GTEx	Thyroid	0.1240	0.0470	2.6e-03	0.013	NA	0.035	NA	0.054	3.3e-02	NA	1.0e-03	NA	5.6e-05
8	ROSMAP	Brain Pre-frontal Cortex	0.0525	0.0198	1.0e-03	0.030	0.008	0.026	0.011	0.026	9.1e-05	2.6e-02	2.2e-04	1.1e-02	2.0e-04
9	YFS	Blood	0.0253	0.0103	6.4e-04	0.008	0.007	0.007	0.008	0.009	8.4e-04	1.3e-03	1.8e-03	8.3e-04	5.6e-04
10	TCGA	Breast Invasive Carcinoma	0.2228	0.0506	1.5e-09	0.095	0.071	0.105	NA	0.102	9.8e-19	2.0e-14	8.3e-21	NA	3.7e-20
11	TCGA	Esophageal Carcinoma	0.2280	0.0830	1.1e-03	0.047	0.040	0.008	NA	0.077	1.3e-02	2.0e-02	1.7e-01	NA	2.0e-03
12	TCGA	Head and Neck Squamous Cell Carcinoma	0.1788	0.0625	1.5e-06	0.038	0.073	0.080	NA	0.086	3.9e-05	1.4e-08	2.5e-09	NA	7.3e-10
13	TCGA	Thyroid Carcinoma	0.3110	0.0760	2.1e-07	0.151	0.122	0.173	NA	0.158	1.5e-14	6.3e-12	1.5e-16	NA	3.8e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Illnesses of father: None of the above (group 1)	3.8	4.6	11.2	2.8	3.3	-3.1	1.8	1.2	1.6	-0.5	2.9	-2.2	-1.7	0.7	-1.9	-2.1
Townsend deprivation index at recruitment	3.7	5.2	10.8	-2.8	-3.0	2.7	-1.5	-2.4	-1.8	-0.4	-3.3	3.0	2.2	-0.2	2.3	1.5
Mood swings	3.6	6.5	14.4	-2.4	-1.6	-3.7	0.1	-2.5	-3.6	-2.8	-1.8	-1.1	-3.8	0.5	-2.0	-3.5
Commuting to job workplace: Cycle	3.2	3.8	17.6	2.8	4.2	0.5	3.0	0.7	1.8	-0.1	2.7	-1.0	-0.3	0.1	-1.5	0.7
Miserableness	3.0	5.2	14.8	-1.3	-0.9	-2.9	0.8	-1.9	-2.5	-2.2	-0.8	-1.9	-3.7	1.8	-2.3	-3.9
Neuroticism score	2.8	5.9	20.7	-0.5	-0.2	-3.7	0.4	-0.4	-2.6	-2.3	-0.4	-1.5	-4.5	1.2	-3.2	-3.9
Number of live births	2.8	3.9	13.2	-0.6	0.4	3.6	-0.5	-0.3	1.4	2.3	-0.1	2.6	2.9	-0.4	2.5	2.7
Depressed Affect (Nagel 2018)	2.7	5.8	19.2	-0.5	-0.2	-4.4	1.1	-0.5	-2.4	-1.4	0.0	-2.7	-4.1	1.1	-2.7	-3.6
Length of working week for main job	2.6	2.9	8.2	1.2	0.8	2.6	0.2	2.3	1.0	2.3	0.8	1.7	2.1	-0.6	1.0	2.9
Medication: Paracetamol	2.6	4.3	13.6	1.3	0.7	-3.2	1.6	-0.3	-0.8	-2.2	0.8	-2.1	-2.8	2.2	-2.0	-3.7
Fractured/broken bones in last 5 years	2.6	3.3	7.8	2.3	1.9	-1.5	0.9	0.5	0.5	-1.9	2.3	-2.8	-1.9	-2.0	-1.5	-2.0
Neuroticism	2.4	5.8	22.4	-0.5	0.1	-3.9	1.0	0.4	-2.8	-0.9	-0.2	-1.1	-4.7	1.0	-3.4	-3.8
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	9.3	1.1	1.1	-2.6	0.2	0.2	-0.9	-1.0	0.7	-1.3	-3.1	0.2	-2.8	-2.6
Irritability	2.3	3.9	10.1	-0.9	-1.4	-2.8	-1.1	-1.0	-1.6	-2.7	-1.5	-1.5	-3.2	0.8	-2.3	-2.9
Breastfed as a baby	2.2	2.8	15.2	0.4	0.5	2.1	-1.3	2.3	0.2	3.9	1.1	1.3	1.7	-1.1	0.3	1.5
Prospective memory result	2.1	2.6	11.1	-1.2	0.0	1.3	0.7	1.5	-2.0	3.3	-0.1	3.1	-0.1	-0.9	-0.6	1.3
Arm fat mass (right)	2.1	8.9	22.3	-3.5	-4.3	1.9	-3.8	-1.9	-1.5	0.9	-3.6	4.7	3.1	1.0	3.0	2.0
Leg fat mass (right)	2.1	8.1	20.4	-3.2	-4.0	2.2	-3.6	-1.5	-1.3	1.5	-3.0	4.5	3.5	0.4	3.1	2.0
Arm fat mass (left)	2.1	8.6	21.8	-3.4	-4.2	1.8	-3.8	-2.0	-1.4	0.8	-3.5	4.7	3.0	1.0	3.1	1.9
Mother’s age at death	2.1	2.6	10.6	2.3	1.6	-0.8	1.4	1.1	0.7	-1.2	2.3	-3.2	-0.8	-1.9	-0.6	-0.3
Body mass index (BMI)	2.0	8.5	20.9	-3.4	-4.1	2.3	-3.5	-1.7	-1.4	1.0	-3.3	4.6	3.2	0.8	3.3	2.0
Medication: Cholesterol lowering	2.0	3.1	10.2	-0.7	0.7	3.2	-0.9	-1.4	1.1	0.7	-0.0	2.9	2.1	-0.1	1.8	2.8
Medication: Omeprazole	2.0	2.4	7.2	0.8	0.5	-2.5	-0.0	-0.1	-1.6	-0.8	0.4	-0.8	-2.7	0.6	-2.7	-2.4
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	11.7	2.2	0.7	-1.4	1.5	1.7	-2.3	0.2	1.8	-0.7	-1.7	-1.9	-3.4	-0.9
Leg fat mass (left)	2.0	7.7	18.9	-3.2	-3.8	2.2	-3.5	-1.6	-1.2	1.4	-3.0	4.3	3.3	0.6	3.0	2.0
Neuroticism (Nagel 2018)	1.9	4.6	16.5	-1.5	-0.4	-3.4	-0.3	-0.2	-2.6	-1.3	-1.1	-1.3	-4.1	0.6	-2.6	-3.3
Fed-up feelings	1.9	3.5	10.1	0.4	-0.1	-3.2	-0.0	-0.3	-2.1	-1.4	0.9	-2.2	-2.9	0.9	-2.0	-3.1
Medication: Simvastatin	1.9	2.8	7.5	-1.9	-1.3	2.4	-1.1	-1.3	-0.5	1.3	-1.0	2.7	1.8	-0.4	1.9	2.3
Hip circumference	1.9	8.2	22.7	-4.1	-3.7	1.8	-4.0	-1.4	-2.0	1.7	-3.2	4.8	2.5	-0.5	2.6	1.7
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.7	-0.2	0.0	-2.4	-0.3	0.3	-2.2	-0.9	0.0	-1.2	-2.6	0.4	-1.9	-2.1
Neuroticism (2016)	1.8	2.5	8.2	-0.7	0.1	-1.9	1.0	0.2	-2.1	-1.4	-0.6	-0.8	-2.9	1.7	-2.5	-1.9
Hearing difficulty/problems: Yes	1.8	2.7	8.7	-0.2	0.3	1.7	-0.5	2.0	-1.1	2.4	0.6	2.9	1.7	-1.8	-0.3	2.4
Weight	1.8	9.0	31.7	-3.2	-3.5	2.4	-3.8	-1.2	-1.3	2.4	-2.8	5.6	3.6	-0.2	2.9	2.3
Emphysema/chronic bronchitis	1.8	2.0	7.5	-0.5	-1.1	1.5	-1.0	0.6	-1.3	0.8	-0.5	2.7	2.0	-1.7	0.0	2.0
Migraine (self-reported)	1.8	2.2	8.4	1.2	0.4	-2.0	2.0	0.7	0.4	-1.9	0.3	-2.9	-1.7	0.8	-1.0	-1.3
Mean time to correctly identify matches	1.8	3.5	8.9	1.2	1.2	2.8	0.8	1.7	0.5	3.0	1.4	2.3	2.6	-0.5	0.6	2.6
Basal cell carcinoma (self-reported)	1.8	2.2	8.4	1.1	2.9	-0.8	1.5	0.4	2.0	-1.1	1.0	-2.4	-1.1	0.7	-0.5	-1.2
Mouth/teeth dental problems	1.7	2.6	9.6	0.8	1.7	2.4	0.2	0.5	3.1	0.1	1.1	0.3	2.5	-0.3	1.5	2.0
Worry too long after embarrassment	1.7	2.9	10.8	-0.2	1.1	-2.1	-0.0	1.8	-1.5	0.5	0.7	-0.4	-3.3	0.6	-3.1	-2.3
Whole body fat mass	1.7	7.1	18.3	-3.3	-3.8	1.5	-3.6	-1.7	-1.2	1.1	-3.3	4.3	2.8	0.7	2.7	1.6
Illnesses of father: High blood pressure	1.7	2.1	7.4	-1.7	-2.7	-0.4	-1.1	-1.0	-1.7	-2.2	-2.2	0.5	-0.6	1.4	0.4	-0.0
Fasting Glucose	1.6	1.9	4.7	1.5	0.8	-1.6	1.5	0.6	-1.2	-0.5	1.9	1.6	-1.0	1.5	-2.2	-0.9
Chronic bronchitis/emphysema (father)	1.6	1.8	6.0	-0.8	-1.6	1.5	0.4	-0.3	0.7	1.4	-0.8	1.2	2.4	-1.0	2.1	1.3
Arm fat percentage (right)	1.6	6.1	16.8	-3.1	-4.1	0.9	-3.1	-1.9	-1.6	-0.3	-3.5	3.1	2.1	1.8	2.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	5.8	0.1	-0.3	-1.9	0.4	-0.6	-2.4	-2.3	0.3	-1.1	-2.4	1.9	-1.4	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	6.9	-0.1	-0.1	-2.5	0.8	-1.8	-1.3	-2.5	-0.2	-1.3	-2.6	-0.2	-1.8	-1.7
Qualifications: College or University degree	1.6	5.1	16.5	3.1	1.9	-2.9	1.6	0.9	1.9	-2.7	2.1	-4.1	-2.4	-0.0	-1.4	-1.6
Suffer from ‘nerves’	1.6	2.5	7.2	-0.8	-0.8	-1.4	-0.5	-1.3	-2.4	-1.6	-1.1	0.8	-2.7	-0.5	-2.1	-2.2
Arm fat percentage (left)	1.6	6.3	16.3	-3.0	-4.0	1.2	-3.0	-1.9	-1.3	-0.0	-3.4	3.5	2.4	1.7	2.6	1.4
Arm fat-free mass (left)	1.6	7.9	30.7	-2.9	-3.0	2.4	-3.8	-1.4	-1.2	2.2	-2.4	5.5	3.2	-0.6	2.6	2.0
Myopia	1.6	2.4	6.1	-1.5	-2.5	0.4	-2.0	-1.5	-1.6	-0.3	-1.9	1.7	1.6	1.0	1.3	1.1
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	5.2	-0.0	1.1	1.3	1.1	1.6	0.6	2.3	0.0	1.0	1.0	-2.0	0.1	1.7
Leg fat percentage (right)	1.5	5.6	15.9	-3.1	-4.0	1.3	-3.0	-1.8	-1.1	0.4	-3.0	2.9	2.4	0.8	2.6	1.1
Arm fat-free mass (right)	1.5	7.7	31.7	-2.7	-2.6	2.4	-3.6	-1.1	-0.8	2.8	-2.0	5.6	3.3	-0.8	2.8	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	5.1	1.0	-0.9	-1.0	0.9	0.3	-2.2	-1.5	0.7	-1.0	-1.4	-1.1	-1.6	-1.7
Qualifications: nursing, teaching	1.5	2.4	4.1	2.0	1.7	-1.7	1.4	2.0	0.9	-0.1	1.7	-2.0	-1.8	0.4	-1.8	-0.8
Diastolic blood pressure, automated reading	1.5	4.7	14.9	-2.3	-3.9	-2.3	-2.0	-1.9	-2.8	-2.2	-2.6	0.2	-1.1	2.0	0.7	-1.8
Reaction Time	1.4	2.7	7.3	0.9	0.7	2.5	0.1	1.1	0.3	2.6	1.0	2.3	2.7	0.6	0.9	2.0
HDL Cholesterol	1.4	2.3	6.5	2.5	1.9	-0.4	1.7	1.8	1.7	0.3	1.6	-2.2	-0.5	-0.3	-1.7	-0.7
Trunk fat mass	1.4	5.9	15.5	-3.2	-3.4	1.0	-3.3	-1.7	-1.0	1.1	-3.1	3.9	2.3	0.7	2.2	1.3
Pain all over the body in last month	1.4	1.5	3.6	-1.0	-1.8	-0.9	-1.3	-1.8	-0.7	-1.9	-1.7	0.0	-0.7	0.1	0.4	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	4.7	-1.9	-2.2	0.2	-1.1	-1.4	-0.9	-0.9	-2.1	0.7	-0.2	1.5	0.3	-0.6
Lung cancer (father)	1.4	1.7	3.0	-1.6	-1.1	-1.4	-0.6	-1.5	-1.5	-1.7	-1.7	-0.6	-1.4	1.0	-0.7	-1.2
Gout (self-reported)	1.4	2.0	7.4	1.7	1.1	-0.6	2.7	2.0	1.6	1.3	1.9	-0.1	-0.5	0.6	-1.0	-0.5
Number of children fathered	1.4	1.6	6.4	2.2	1.8	-0.5	0.9	0.4	2.5	0.6	2.0	-0.4	0.9	0.4	-0.1	-0.5
Arm predicted mass (right)	1.4	7.2	29.6	-2.5	-2.6	2.1	-3.6	-1.0	-0.9	2.7	-2.0	5.4	3.1	-0.9	2.5	1.8
Number of full sisters	1.4	1.7	4.8	-1.4	-2.0	0.0	-0.7	-1.2	-2.2	0.4	-1.9	1.2	-1.0	-1.6	-0.6	-0.3
Friendships satisfaction	1.4	1.7	5.6	1.5	1.8	0.6	1.3	1.3	0.4	2.4	2.1	0.3	-0.2	-0.5	-1.3	0.5
Hearing aid user	1.4	1.6	10.1	-1.2	-0.5	0.3	-0.5	-0.2	-2.0	-0.1	-0.6	1.4	-0.8	-3.2	-0.9	-0.9
Eye problems/disorders: Glaucoma	1.4	1.7	3.4	1.7	1.5	-0.9	1.7	1.1	1.8	1.1	1.7	-0.7	-0.2	-1.8	-0.6	-0.3
Basal metabolic rate	1.4	7.5	32.2	-2.4	-2.8	2.3	-3.6	-0.9	-1.0	2.4	-2.0	5.7	3.3	-0.7	2.5	2.0
Leg fat percentage (left)	1.4	4.9	12.0	-3.0	-3.5	1.3	-2.8	-1.9	-1.0	0.6	-2.8	2.7	2.2	0.8	2.4	1.3
Arm predicted mass (left)	1.4	7.1	27.3	-2.7	-2.9	2.2	-3.7	-1.3	-1.1	2.0	-2.3	5.2	3.0	-0.5	2.6	1.8
BMI	1.3	7.7	26.6	-2.5	-3.2	2.9	-2.3	-0.3	-0.8	2.0	-2.2	5.2	3.8	0.1	3.1	2.9
Hand grip strength (left)	1.3	3.5	10.3	1.1	-0.2	-3.2	1.8	-0.9	1.7	-1.3	0.1	-2.9	-2.1	-0.4	-1.6	-3.2
Leg fat-free mass (left)	1.3	6.7	29.2	-2.1	-2.7	2.3	-3.1	-0.6	-0.7	2.4	-1.9	5.4	3.3	-0.7	2.4	2.0
Leg predicted mass (left)	1.3	6.9	29.8	-2.1	-2.7	2.4	-3.1	-0.6	-0.7	2.4	-2.0	5.5	3.4	-0.7	2.4	2.1
Qualifications: None of the above	1.3	2.7	5.4	-2.2	-2.1	0.7	-0.4	-2.0	-2.1	1.7	-2.0	2.3	0.3	-1.9	0.3	-0.9
Pulse rate	1.3	2.2	7.6	0.5	0.7	-1.3	0.9	2.8	-2.2	0.3	0.4	-0.4	-2.1	-2.0	-1.8	-1.0
Hair/balding pattern: Pattern 4	1.3	3.3	11.4	-2.9	-2.0	-0.4	-1.5	-3.4	0.1	-1.6	-3.0	0.5	-0.0	0.9	1.9	-0.5
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	5.2	-1.5	-2.2	-0.6	-2.1	-0.3	-1.1	-0.0	-1.7	0.6	-0.2	2.3	0.3	0.5
Body fat percentage	1.3	5.1	12.4	-3.2	-3.5	0.7	-3.0	-1.9	-1.1	0.4	-3.3	2.9	1.9	1.2	2.1	0.9
Age at first live birth	1.3	2.4	6.9	2.0	1.4	-2.6	0.2	1.3	0.6	-0.7	2.2	-2.2	-1.4	1.4	-1.1	-0.9
Medication: Blood pressure	1.3	2.2	6.1	-1.7	-1.2	1.5	-1.9	-0.7	-0.2	0.3	-1.2	1.6	1.4	2.5	2.0	1.4
Medication: Allopurinol	1.3	1.7	6.2	2.2	0.4	-0.2	2.1	1.2	2.5	0.8	1.6	-0.2	0.8	0.9	0.1	0.3
Guilty feelings	1.3	2.0	7.2	-0.8	-0.2	-1.8	0.1	0.7	-1.3	-0.7	-0.2	-0.8	-2.7	2.6	-1.5	-1.7
Unable to work because of sickness or disability	1.3	1.7	5.2	-1.4	-1.4	-0.3	-1.4	-2.3	-0.8	-2.2	-1.6	-0.7	-0.8	-0.3	0.9	-0.9
Waist circumference	1.2	4.6	12.9	-2.8	-3.6	0.5	-2.4	-2.0	-1.0	0.5	-2.8	3.3	1.7	0.6	2.1	0.5
Hair/balding pattern: Pattern 2	1.2	1.6	7.2	0.9	0.5	-1.4	0.7	0.5	-0.2	-0.7	0.5	-1.3	-1.9	-0.4	-1.8	-2.7
Impedance of arm (right)	1.2	5.6	19.7	2.2	2.3	-3.1	2.4	0.4	1.0	-2.0	1.4	-4.4	-2.9	0.6	-2.9	-2.0
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	4.4	1.0	-0.2	-1.9	1.4	1.0	-0.6	-0.1	0.2	-1.8	-1.7	-2.1	-1.8	-2.0
Whole body fat-free mass	1.2	6.6	30.7	-2.0	-2.2	2.3	-3.2	-0.6	-0.7	2.6	-1.5	5.5	3.2	-0.9	2.3	2.0
Whole body water mass	1.2	6.7	30.4	-2.1	-2.4	2.3	-3.3	-0.8	-0.8	2.4	-1.7	5.5	3.2	-0.9	2.4	1.9
Ever depressed for a whole week	1.2	1.5	3.7	0.3	0.7	-1.6	0.0	-0.4	-1.8	-1.9	0.7	-1.2	-1.6	-1.4	-1.7	-0.2
Impedance of whole body	1.2	5.9	21.6	1.6	2.2	-3.2	2.2	0.3	0.9	-1.8	1.2	-4.6	-3.4	0.5	-3.0	-2.5
Waist Hip Ratio (WHR)	1.1	4.8	14.9	1.3	-0.3	-3.9	1.7	-2.0	1.1	-2.7	-0.0	-2.8	-2.7	0.9	-1.8	-3.2
Systolic Blood Pressure	1.1	5.3	24.3	-2.8	-2.8	-0.8	-1.8	-3.0	-0.9	-1.0	-3.1	0.5	0.1	4.9	2.0	-0.6
Type 2 Diabetes (T2D) (2018)	1.1	2.1	6.2	0.1	-0.5	1.6	-0.5	-0.1	2.0	0.9	0.1	1.6	2.5	1.6	2.1	2.0
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.5	-1.9	-1.0	-0.9	-1.6	-1.6	-1.5	-0.5	-1.3	1.1	-1.4	0.9	-0.1	-1.2
Relative age of first facial hair	1.1	2.3	8.8	2.4	2.3	-1.2	1.5	0.3	1.9	-0.1	3.0	-1.2	-0.3	0.3	-0.9	0.1
Diabetes (father)	1.1	1.4	4.4	-2.1	-0.7	0.2	-1.9	0.1	-1.7	0.1	-1.1	2.1	-0.7	0.3	0.6	0.3
Trunk fat percentage	1.1	4.5	11.3	-3.2	-3.3	0.1	-2.9	-2.0	-1.1	0.2	-3.4	2.6	1.2	1.2	1.7	0.5
Age when periods started (menarche)	1.1	2.7	8.2	1.7	0.2	-1.8	1.0	0.8	0.6	-1.0	1.2	-2.1	-2.1	-0.9	-2.9	-2.6
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.6	-1.6	-1.6	-1.8	-1.2	-0.3	-2.1	-1.2	-1.4	0.3	-1.6	0.5	-0.1	-1.1
Happiness	1.1	1.3	4.2	1.0	2.1	-0.2	1.5	1.2	0.4	1.3	1.7	-0.7	-0.7	-0.3	-1.3	-0.1
Noisy workplace	1.1	1.3	8.1	-0.3	0.2	-0.5	-0.6	0.0	-2.0	0.8	-0.2	1.2	-0.2	-2.8	-1.4	-0.0
Impedance of arm (left)	1.1	5.1	17.0	1.9	2.1	-3.1	2.4	0.3	1.3	-2.0	1.1	-4.1	-2.9	0.7	-2.4	-2.1
Medication: Amlodipine	1.1	1.5	7.5	-0.7	-1.2	0.5	-0.5	-0.4	1.3	-0.3	-0.6	0.6	1.4	2.7	2.1	1.0
Medication for pain relief, constipation, heartburn	1.1	1.9	6.7	0.0	0.8	1.6	-0.2	1.4	1.2	1.9	0.3	0.4	1.8	-1.8	0.9	2.6
Supplements: Vitamin C	1.1	1.3	2.7	0.9	1.2	-1.5	1.6	0.3	0.3	-1.1	0.2	-1.6	-1.4	1.2	-1.0	-0.8
Leg fat-free mass (right)	1.1	5.9	27.8	-1.8	-2.1	2.2	-2.7	-0.6	-0.6	2.5	-1.6	5.3	3.1	-0.8	2.1	2.1
Leg predicted mass (right)	1.1	5.8	26.9	-1.8	-2.0	2.2	-2.7	-0.6	-0.5	2.4	-1.6	5.2	3.1	-0.8	2.1	2.1
Commuting to job workplace: Public transport	1.1	1.3	3.2	1.6	1.7	0.5	0.2	1.8	-0.7	1.2	1.8	-0.4	-0.5	-0.5	-1.5	-0.6
Medication: Paracetamol	1.1	1.7	5.6	0.8	0.5	-2.3	1.0	0.2	-0.4	-0.9	0.6	-0.9	-1.7	1.6	-1.4	-2.4
Risk taking	1.1	1.6	5.5	1.5	0.5	-2.3	1.6	0.8	-0.5	-1.2	1.0	-2.3	-0.7	-0.6	-1.0	-0.5
Schizophrenia vs Biploar Disorder	1.0	1.3	6.4	1.1	-0.7	-0.8	0.3	-0.2	1.2	-2.5	-0.2	-2.0	-0.4	0.5	0.2	-1.5
Alzheimer’s Disease (including proxy)	1.0	1.4	4.3	-1.5	-2.1	-0.9	-1.0	-1.0	-0.8	0.4	-1.5	0.8	-0.1	-1.2	1.2	-1.6
Rheumatoid Arthritis	1.0	1.4	3.6	-1.9	-0.4	1.4	-1.7	-0.4	-0.9	0.8	-1.5	1.2	0.3	-1.9	-0.0	0.9
Average weekly spirits intake	1.0	1.2	3.2	-1.8	-1.3	1.0	-0.9	0.3	-1.5	1.4	-1.2	1.4	0.7	-0.5	0.5	0.8
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.8	1.1	-0.4	-1.7	1.6	-1.1	-0.4	-1.4	0.4	-1.6	-1.2	-0.9	-1.0	-0.9
Systolic blood pressure, automated reading	1.0	3.0	7.7	-2.3	-2.5	-0.9	-2.0	-2.2	-0.8	-1.5	-2.8	0.8	0.4	1.6	2.0	-0.2
Supplements: Zinc	1.0	1.1	3.4	0.5	0.4	-0.8	1.8	0.8	-0.6	-0.3	-0.0	-1.3	-1.6	-0.3	-1.8	-1.2
Medication: Co-codamol	1.0	1.1	3.8	-1.5	-1.9	0.4	-1.0	-1.5	-0.9	-0.9	-1.2	0.4	-0.1	0.5	1.0	-0.8
Average weekly fortified wine intake	1.0	1.2	2.9	0.3	0.8	-1.6	0.8	0.8	-0.6	-0.8	0.7	-1.7	-1.6	-0.3	-1.7	-1.3
Impedance of leg (left)	1.0	4.7	17.7	1.2	2.1	-2.8	1.8	-0.1	0.5	-1.2	1.3	-4.2	-3.2	0.4	-2.7	-2.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	6.0	0.0	-0.0	-1.5	0.0	-0.5	-0.6	-2.5	-0.4	-1.5	-1.3	1.7	-0.7	0.3
Diabetes (self-reported)	1.0	1.5	4.8	0.9	0.6	1.2	-0.5	-0.7	2.2	0.2	0.9	0.9	1.8	1.1	1.6	1.5
Trunk fat-free mass	1.0	5.8	28.2	-1.5	-1.7	2.2	-3.0	-0.4	-0.5	2.6	-0.8	5.3	3.2	-1.2	2.1	2.1
Hair/balding pattern: Pattern 3	1.0	1.5	5.2	-0.0	0.4	1.4	-1.3	1.2	-0.5	0.8	0.7	1.5	1.8	-1.8	0.4	2.3
Asthma	1.0	1.9	5.0	1.1	0.4	-1.6	1.3	0.6	-1.9	-1.7	0.5	-1.5	-1.7	-0.4	-2.2	-1.4
Trunk predicted mass	1.0	5.6	27.6	-1.5	-1.7	2.2	-3.0	-0.5	-0.6	2.4	-0.8	5.3	3.2	-1.1	2.1	2.0
Pulse wave peak to peak time	1.0	1.2	4.2	-1.0	-0.3	0.7	-1.0	-1.4	0.9	-0.3	-0.7	-0.2	1.1	2.0	2.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	7.8	1.2	-0.8	-0.3	0.4	0.8	1.4	-0.8	0.3	-2.8	0.0	0.6	0.3	-1.4
Had major operations	1.0	1.2	3.9	0.3	0.2	1.6	-0.8	-0.1	1.1	0.1	0.5	1.8	1.5	0.5	2.0	1.0
Family relationship satisfaction	1.0	1.2	3.6	0.7	1.3	0.9	0.5	1.5	0.3	1.9	1.7	0.3	0.8	-1.2	-0.0	1.2
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.0	-1.3	-1.5	-0.7	-1.2	-1.7	-0.0	-0.6	-0.9	0.2	0.7	1.0	1.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	7.6	2.2	2.0	-1.0	0.3	2.1	1.6	0.3	2.8	-1.1	-0.7	-0.2	-1.1	-0.4
Medication: Bendroflumethiazide	1.0	1.5	3.1	-1.0	-1.7	-1.3	-0.6	-1.8	-1.4	-1.7	-0.7	-0.7	-1.0	1.7	-0.1	-0.9
Primary Biliary Cirrhosis	0.9	1.3	3.6	-1.1	-0.5	1.9	-0.3	-1.1	0.5	0.6	-0.6	1.0	1.7	1.2	1.5	1.5
Type 2 Diabetes (T2D) (2012)	0.9	1.1	3.0	-0.5	0.4	-1.6	-0.8	-0.8	0.6	-0.9	-0.9	-1.3	-1.3	-0.3	-1.1	-1.7
Blood Platelet Count	0.9	10.5	28.1	-2.5	-0.7	-4.3	0.7	-4.1	-5.3	-2.8	-2.0	-0.7	-5.1	1.1	-3.6	-3.6
Cardiovascular Disease	0.9	3.0	6.9	-2.6	-2.6	0.5	-1.2	-1.4	-2.0	0.7	-1.9	2.3	0.6	2.6	1.0	0.5
Pulse wave Arterial Stiffness index	0.9	1.1	3.9	0.9	0.2	-0.6	0.8	1.3	-0.9	0.4	0.7	0.4	-0.9	-2.0	-1.9	0.3
Tense / ‘highly strung’	0.9	1.5	5.6	-0.3	-0.1	-1.7	-0.3	0.2	0.2	-1.5	-0.6	-1.3	-2.2	0.2	-1.3	-2.4
Health satisfaction	0.9	1.1	4.5	-0.4	0.4	-2.1	0.2	-0.1	-0.8	-0.2	-0.3	-1.1	-1.6	0.8	-1.8	-1.3
Neck or shoulder pain in last month	0.9	1.3	6.5	0.3	-0.0	0.9	-0.3	1.7	-0.8	1.1	0.6	1.7	0.7	-2.6	-0.1	0.9
Heart disease (mother)	0.9	1.1	3.6	0.8	1.1	0.8	-1.0	1.7	1.9	1.1	0.8	0.6	0.8	-0.1	0.3	1.0
Age at last live birth	0.9	1.4	3.8	1.7	1.2	-1.9	-0.4	1.1	0.1	-0.3	1.5	-0.9	-1.6	0.0	-1.3	-1.1
Eye problems/disorders: Cataract	0.9	1.0	4.6	0.9	-0.8	-0.7	1.2	-0.1	1.4	-1.3	-0.1	-2.1	-0.3	0.2	0.2	-1.2
Average weekly champagne plus white wine intake	0.9	1.2	3.6	-1.4	-1.0	-1.3	-0.8	-1.9	-0.4	-0.5	-1.2	0.5	-0.9	0.8	0.7	-1.6
Vascular/heart problems diagnosed by doctor	0.9	2.4	7.5	1.8	2.3	-0.9	1.9	0.5	1.7	-0.9	1.1	-2.0	-0.6	-2.7	-0.9	-0.3
Worry (Nagel 2018)	0.8	1.8	6.8	-0.8	-0.2	-1.9	-0.4	-0.6	-1.2	-1.4	-1.0	0.0	-2.6	0.5	-1.4	-2.1
Alzheimer’s Disease (in mother)	0.8	0.9	2.9	-1.0	-1.7	-0.9	-0.7	-0.8	-0.9	-0.2	-1.1	0.6	0.7	-0.3	1.2	-1.1
Verbal and Numeric Reasoning (VNR)	0.8	1.8	5.6	1.4	1.0	-1.6	0.1	-0.2	2.1	-1.5	1.0	-2.4	-1.4	-0.6	-0.9	-1.3
Crohns Disease (2012)	0.8	1.2	3.2	-1.0	-1.7	-0.3	-1.6	-1.6	0.3	-0.6	-1.8	-0.0	-0.8	0.7	0.9	-1.1
Sensitivity / hurt feelings	0.8	1.4	3.8	-1.9	-1.6	-0.4	-1.3	-1.1	-1.5	-0.6	-1.9	1.2	-0.5	0.6	0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.8	1.5	1.8	0.2	0.5	1.3	1.2	0.3	1.9	-0.4	0.2	0.6	-0.9	0.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	6.2	0.3	-0.5	-0.1	-0.7	-1.0	-0.0	0.3	0.0	1.6	0.3	-2.5	0.2	-0.4
Hand grip strength (right)	0.8	2.0	6.1	1.1	0.2	-2.2	1.2	-1.2	2.1	-1.0	0.7	-1.9	-1.1	0.1	-0.8	-2.5
High blood pressure	0.8	2.3	10.8	-1.6	-2.5	0.6	-1.4	-0.2	-1.6	0.8	-1.1	1.8	0.6	3.3	1.0	0.3
High blood pressure (mother)	0.8	1.1	3.6	1.3	0.1	-1.0	0.5	1.3	0.8	0.5	0.5	-1.0	-0.9	1.9	-0.9	-1.3
Alcohol usually taken with meals	0.8	1.3	5.7	0.9	1.8	-0.2	0.2	2.4	0.8	1.1	1.7	-0.7	-0.8	0.0	-1.0	0.2
Hearing difficulty/problems with background noise	0.8	1.3	4.6	1.5	0.9	0.2	0.3	2.1	-0.6	1.3	1.8	1.2	0.8	-0.7	-1.3	0.4
Heart attack	0.8	1.1	3.8	-0.8	-0.8	1.5	-1.5	-0.9	-0.8	0.8	-0.2	2.0	1.1	-0.1	0.4	0.9
Fluid intelligence score	0.8	1.6	6.3	0.9	0.6	-0.9	-0.8	-1.0	2.0	-2.5	0.5	-2.2	-0.9	0.2	-0.2	-1.0
Illnesses of siblings	0.8	1.1	3.4	-0.3	0.6	1.6	-1.8	-0.8	0.2	-0.4	-0.5	1.5	0.9	-1.4	0.8	1.1
Exposure to tobacco smoke at home	0.8	0.9	4.6	-0.8	-0.8	0.2	0.8	-0.2	-2.1	0.6	-0.6	1.5	-0.4	0.9	-0.4	0.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.7	1.5	1.4	-0.3	0.8	1.6	1.6	0.5	1.5	-1.5	-0.4	1.4	-0.2	-0.1
Glaucoma (self-reported)	0.8	1.0	2.3	1.4	1.0	-0.7	1.1	1.1	0.9	0.5	1.0	-1.0	-0.8	-1.5	-0.9	-0.4
Number of full brothers	0.8	1.0	5.0	-0.0	-0.8	-0.8	1.5	-1.0	-0.6	0.2	-0.7	0.8	-0.3	-2.2	-1.0	-0.5
Shortness of breath walking on level ground	0.8	0.9	3.5	0.7	0.8	0.5	1.6	1.2	0.7	1.9	0.6	0.4	0.6	-0.2	0.1	1.3
Alcohol intake frequency.	0.8	1.9	4.9	-1.1	-0.8	1.4	-0.7	-1.4	-0.0	0.6	-0.8	2.1	2.2	0.9	2.0	1.5
Medication: Aspirin	0.8	1.1	2.7	-0.8	-1.0	1.5	-1.6	-0.2	0.8	0.3	-0.7	1.4	1.2	-0.5	1.6	0.5
Knee pain experienced in last month	0.8	1.3	3.2	1.8	1.5	-0.5	1.3	1.8	-0.8	0.2	1.4	-0.3	0.2	-0.7	-1.6	-0.1
Hypertension (Self-reported)	0.8	2.3	9.1	-1.9	-2.4	0.5	-1.3	-0.7	-1.7	0.4	-1.3	1.9	0.3	3.0	1.0	0.2
Illnesses of father: Heart disease	0.8	1.1	5.0	-0.4	-1.3	2.2	-0.5	-0.1	-1.3	0.5	-0.9	1.1	0.2	-1.7	-0.4	0.7
Ever had bowel cancer screening	0.8	0.9	4.9	-0.7	1.2	1.0	-1.0	-1.0	-0.3	1.0	0.4	2.2	-0.1	0.2	-0.1	0.7
Back pain experienced in last month	0.8	1.2	7.3	-1.5	-1.3	-0.4	0.8	0.1	-2.7	0.1	-0.7	0.7	-0.5	1.4	-0.6	-0.3
Wears glasses or contact lenses	0.8	0.9	2.3	1.2	0.7	-0.1	0.6	0.8	1.1	0.5	1.1	0.7	1.2	0.2	1.2	1.5
Heart attack/myocardial infarction (self-reported)	0.8	1.1	3.7	-1.0	-0.9	1.5	-1.6	-1.0	-1.0	0.7	-0.3	1.9	0.9	-0.0	0.3	0.7
Ever had hysterectomy (womb removed)	0.7	0.8	3.1	0.5	1.4	1.0	0.1	0.9	0.2	0.9	0.8	0.2	1.2	-0.0	-0.0	1.8
Impedance of leg (right)	0.7	3.5	14.7	0.8	1.2	-2.6	1.2	-0.0	0.4	-1.3	0.8	-3.8	-2.9	0.4	-2.2	-2.3
Nervous feelings	0.7	1.3	3.1	-1.7	-1.3	0.7	-1.5	-1.5	-1.1	-0.4	-1.6	1.8	-0.5	0.5	0.6	-0.3
Had menopause	0.7	0.8	2.9	-0.3	0.0	-1.2	0.9	-1.1	0.1	-0.2	-0.6	-1.7	-1.2	-1.5	-0.4	-0.7
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.6	-0.6	-1.1	-0.9	-0.7	-0.5	-0.7	-1.1	-1.3	-1.1	-1.1	1.2	-0.9	-0.7
Worrier / anxious feelings	0.7	1.3	5.1	0.1	0.7	-1.3	0.7	0.4	-1.1	-1.1	0.3	-0.1	-2.2	1.2	-1.6	-1.6
Falls in the last year	0.7	0.9	3.2	-0.0	0.1	0.4	-1.0	0.3	0.8	-0.1	0.1	0.8	1.6	1.5	1.8	1.0
Mouth/teeth dental problems: Dentures	0.7	1.2	4.0	-0.4	0.3	-1.5	0.7	-1.1	-1.2	-0.8	-0.0	-0.8	-1.8	-1.0	-0.9	-2.0
Headache pain in last month	0.7	1.2	5.6	1.0	0.9	-0.5	1.1	-0.6	-0.0	-1.2	1.1	-0.6	-0.9	2.4	-0.8	-1.5
Medication: Seretide 50 evohaler	0.7	0.8	2.5	0.7	1.0	0.2	1.6	0.5	-0.2	0.8	0.7	-0.9	-0.7	1.3	-1.5	0.1
Long-standing illness, disability or infirmity	0.7	1.1	3.3	1.2	1.0	-0.4	1.1	-0.1	0.4	-1.8	1.3	-1.6	0.0	1.2	-1.0	-0.4
Breast cancer (self-reported)	0.7	0.8	2.0	-0.3	0.8	-1.4	0.5	-0.6	0.0	-1.4	-0.1	-0.7	-1.3	0.8	-0.6	-1.4
Asthma (self-reported)	0.7	1.4	3.9	0.9	0.6	-1.2	1.3	0.8	-1.7	-1.3	0.4	-1.3	-1.5	-0.3	-2.0	-1.0
Osteoporosis (self-reported)	0.7	0.9	3.6	0.9	0.1	-1.9	0.8	0.5	-0.3	-0.9	0.6	-1.2	-0.8	-1.0	-1.1	-0.4
Medication: Aspirin	0.7	0.9	2.1	-0.9	-1.2	1.2	-1.4	0.0	0.5	0.3	-0.8	1.4	1.0	-0.1	1.4	0.4
Financial situation satisfaction	0.7	0.9	7.9	-0.4	-0.8	-0.5	-0.1	-0.4	-2.8	-0.4	-0.2	-0.6	-0.9	0.4	-1.1	-0.1
Medication: Atorvastatin	0.7	0.8	4.1	0.1	0.4	-0.1	0.3	-1.2	1.0	-2.0	-0.6	-1.5	-0.7	0.2	-0.1	-0.9
Number of operations (self-reported)	0.7	1.0	2.6	-1.0	-0.6	0.3	-1.2	-1.2	-0.4	-1.3	-1.1	1.4	0.7	0.7	1.6	0.3
Cholesterol lowering medication	0.7	1.0	3.1	-1.8	-1.6	0.5	-0.5	-1.7	-1.0	-0.1	-1.4	0.8	0.2	-0.2	0.8	-0.1
Alcohol drinker status: Previous	0.7	0.8	4.3	-0.7	-0.3	0.5	-0.1	0.0	1.2	1.1	-0.4	0.1	0.6	2.1	1.3	0.8
Depression (Nagel 2018)	0.6	0.9	2.4	-1.5	-0.5	-1.2	-1.0	-0.4	-1.1	-0.4	-1.0	0.8	-1.6	0.7	-0.4	-0.6
Alzheimer’s Disease (in father)	0.6	0.6	1.8	-1.1	-0.3	-0.5	-0.8	-1.0	0.0	0.6	-0.6	0.1	-1.0	-0.8	0.5	-1.4
HbA1C	0.6	0.6	2.1	0.4	0.4	1.4	-0.4	0.1	0.0	1.2	0.5	1.2	0.7	1.4	-0.2	0.4
Respiratory disease	0.6	1.4	3.7	1.3	1.9	-0.9	1.6	0.0	-0.8	-1.5	1.4	-1.5	-0.9	0.2	-1.3	-0.3
Vitamin and mineral supplements	0.6	0.8	2.8	-0.2	-0.7	1.4	-0.8	0.1	-1.6	0.5	0.1	0.4	0.9	-1.7	0.1	0.7
Severe depression (siblings)	0.6	0.7	2.9	-0.4	-0.1	-0.4	-0.8	-0.9	1.7	-0.3	-0.6	-0.3	0.8	-0.4	1.7	0.4
Medication: Atenolol	0.6	0.8	3.0	-1.1	-0.6	-1.2	-0.2	0.2	-1.1	1.7	-0.5	0.8	-0.6	1.1	-0.0	-0.5
Sitting height	0.6	4.3	17.2	-1.3	0.2	2.4	-1.9	0.7	-0.2	3.1	-0.6	4.2	2.1	-1.8	0.7	3.0
Had other major operations	0.6	0.7	2.1	-0.9	0.2	-0.4	-1.5	-1.3	1.1	-1.1	-1.0	0.3	0.2	0.3	1.0	-0.2
Forced vital capacity (FVC)	0.6	2.5	6.4	1.7	0.9	-1.8	1.7	1.0	1.3	-0.9	1.5	-2.5	-1.8	-0.3	-1.9	-1.7
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.7	1.9	1.1	-1.4	1.2	1.2	1.7	-0.6	1.8	-1.9	-1.3	0.2	-1.3	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.5	0.6	0.1	-0.7	1.9	0.1	-1.1	-0.8	0.7	-0.4	-1.0	0.9	-1.0	-0.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.1	0.8	1.2	-1.0	-0.1	0.3	-0.7	-0.7	0.9	-0.6	-0.7	1.4	-1.0	-0.3
Exposure to tobacco smoke outside home	0.6	0.8	3.1	-0.9	-1.5	0.9	-0.4	-0.3	-1.8	-1.1	-1.2	0.5	0.4	0.6	0.2	0.4
Wheeze or whistling in the chest in last year	0.6	1.1	3.4	-0.9	-1.3	0.9	0.0	-1.5	-1.9	-0.6	-1.1	1.4	0.8	-0.8	0.8	0.8
Commuting to job workplace: Walk	0.6	0.7	3.9	0.1	-0.3	-0.3	1.1	-0.1	-0.1	-2.0	-0.4	-0.7	-1.1	0.1	-0.4	-1.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.6	-1.1	-0.9	0.2	-0.6	-0.9	0.3	-1.5	-0.6	0.5	0.3	1.6	1.3	0.1
Ulcerative Colitis (UC)	0.5	1.0	3.2	0.7	0.4	-1.1	0.8	0.2	-1.3	0.2	1.1	0.0	-1.7	-0.1	-1.8	-1.0
Major Depression (MDD)	0.5	0.7	3.9	-0.7	-0.4	-0.7	-0.2	-1.0	-0.3	-2.0	-0.8	-1.0	-0.5	0.6	0.0	0.4
Bipolar Disorder (2011)	0.5	0.4	1.1	0.7	0.8	0.2	0.4	0.6	0.3	1.0	0.7	0.9	-0.2	-0.3	-0.6	1.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.1	-0.2	0.5	1.5	-1.0	-0.7	1.1	-0.1	-0.0	0.8	0.8	0.7	0.8	1.2
Ulcerative Colitis	0.5	0.7	2.6	-0.6	-1.0	-0.8	-1.6	-0.7	-1.1	-0.9	-0.4	0.5	-0.8	0.5	-0.1	-0.8
Allergy or Eczema	0.5	1.3	3.5	1.7	1.1	-0.8	1.2	-0.3	1.5	-1.8	0.7	-1.9	-0.3	1.0	-0.3	-0.2
Hypothyroidism (self reported)	0.5	1.1	5.4	-0.0	-0.5	2.3	-0.7	0.3	1.5	1.4	-0.0	-0.1	1.5	-0.4	1.0	1.0
Lung FVC	0.5	2.8	12.0	0.7	0.5	-1.9	2.0	-0.1	0.1	-2.2	0.8	-3.5	-2.3	-1.3	-1.4	-1.4
Number of treatments/medications taken	0.5	0.9	4.3	-0.2	-0.8	-1.1	0.6	-0.6	-1.4	-1.0	-0.0	-0.8	-0.6	2.1	-0.5	-0.7
Angina	0.5	0.6	2.1	-0.4	-0.1	0.7	-0.4	-0.5	-1.1	0.9	0.0	1.4	0.1	-1.5	-0.3	0.6
Medication: Metformin	0.5	0.7	1.9	0.1	-0.4	0.4	-0.4	-1.2	1.0	0.0	-0.4	1.4	1.0	0.9	1.4	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	-0.8	-0.3	-0.7	-0.6	-0.3	-1.5	-1.0	-0.0	0.3	-1.1	1.1	-0.7	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.7	1.6	0.6	-1.2	0.4	1.0	-0.5	-1.3	1.2	-0.8	-0.8	-0.2	-1.6	-1.3
Qualifications: CSEs or equivalent	0.5	0.7	3.4	-0.2	-0.9	0.8	-0.5	0.6	-1.8	0.4	-0.5	1.3	0.3	0.4	-0.8	0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.8	1.0	1.3	0.6	0.2	1.0	0.8	-0.5	1.3	-0.8	0.3	0.2	-0.1	0.6
Hayfever, allergic rhinitis or eczema	0.5	1.0	3.7	1.4	0.2	-0.5	0.8	-0.3	1.2	-1.6	0.5	-1.4	-0.4	1.9	-0.3	-0.6
Multivitamins +/- minerals	0.5	0.6	2.2	-0.7	0.0	-0.7	0.2	-1.0	1.0	0.1	-0.6	1.3	-0.5	1.5	0.5	-0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.7	1.0	1.0	-0.4	0.3	0.9	0.7	0.7	1.0	-1.6	-0.1	-0.4	-0.1	-0.6
Medication: Ramipril	0.5	0.6	2.6	0.5	-0.4	1.0	0.8	-0.1	0.2	-0.0	-0.2	0.2	1.0	1.5	0.3	1.6
Time employed in main current job	0.5	0.5	3.4	-0.1	-0.3	-0.4	1.3	0.1	-1.8	0.4	0.2	0.0	-0.4	-0.6	-0.6	-0.3
Alcohol intake versus 10 years previously	0.5	0.8	3.8	-0.6	-0.3	0.0	-0.9	-1.2	-1.4	1.1	-0.5	1.9	0.2	0.5	-0.1	0.1
Depression (self-reported)	0.5	0.6	1.6	-0.1	-0.9	-1.3	-1.0	-0.3	-0.3	-1.2	-0.4	-1.0	-0.5	-0.5	-0.1	-1.1
Medication: Lansoprazole	0.5	0.6	3.4	-0.5	-1.8	0.0	0.1	0.3	-0.4	0.6	-0.2	0.9	1.1	-0.5	0.8	0.9
Birth weight of first child	0.5	0.9	3.0	1.2	1.7	0.4	1.2	-0.2	1.0	-1.2	1.2	-1.0	0.4	0.1	0.1	0.6
Comparative body size at age 10	0.5	1.3	3.5	-0.9	-1.9	1.2	-1.6	0.0	-1.3	-0.5	-0.9	0.9	1.0	0.7	1.4	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.7	0.3	-0.7	-1.2	0.3	-0.3	-1.3	-1.1	-0.1	-0.4	-1.0	-1.1	-1.2	-0.2
Eye problems/disorders: None of the above	0.5	0.5	2.8	-0.8	-0.1	0.4	-0.6	-0.1	-1.4	-0.2	-0.6	0.4	-0.0	1.7	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.7	1.2	1.5	0.1	0.4	0.6	-1.1	1.6	1.6	1.3	-0.6	-0.3	-1.0	-0.3
Diabetes diagnosed by doctor	0.5	0.7	2.0	0.2	-0.4	0.9	-0.4	-0.7	1.2	0.5	0.1	1.2	1.4	0.6	1.3	0.8
Mineral and other dietary supplements	0.5	0.6	2.4	1.5	0.6	-0.0	0.6	0.6	-0.1	0.5	1.0	-1.0	-0.4	-1.0	-1.1	-0.4
Smoking status: Current	0.5	0.8	1.9	1.3	1.3	1.4	1.1	0.4	0.3	-0.4	1.0	-0.2	0.6	-0.7	-0.3	1.1
Ever taken oral contraceptive pill	0.5	0.5	2.7	0.7	-0.3	0.6	-1.6	-0.9	0.8	-0.3	0.1	0.9	0.5	0.3	0.6	0.4
Medication: Blood pressure	0.5	1.0	2.4	-0.6	-1.2	-1.1	0.1	0.1	-1.5	1.1	-0.3	0.8	-1.1	1.2	-1.3	-1.1
Alcohol drinker status: Never	0.5	0.6	1.9	0.4	0.5	0.8	0.5	0.1	1.4	0.7	1.1	-0.6	0.4	1.4	0.5	0.5
Average weekly beer plus cider intake	0.5	0.7	2.4	0.6	-0.5	-1.1	0.8	-0.5	0.2	0.3	-0.8	-0.4	-1.2	-0.3	-0.9	-1.6
Ever had prostate specific antigen (PSA) test	0.5	0.5	3.0	0.2	0.4	-0.9	-0.2	-0.2	1.7	-0.7	0.4	-1.1	0.2	0.9	0.6	0.3
Bipolar Disorder (2018)	0.4	0.6	2.6	-0.7	0.3	-0.1	-0.7	0.7	-0.3	1.6	-0.1	1.6	0.0	0.1	0.6	1.0
Intelligence (Savage-Jansen 2018)	0.4	1.4	5.8	1.4	-0.1	-0.7	-1.0	-0.5	2.4	-1.7	0.8	-1.3	-0.2	1.4	0.7	-0.6
Irritable Bowel Disease (IBD)	0.4	0.9	3.2	0.4	-0.4	-1.7	0.1	0.3	-1.0	0.2	0.4	-0.3	-1.8	-0.2	-1.2	-1.3
Ovarian Cancer	0.4	0.5	1.3	0.4	0.2	-1.0	0.5	0.1	-0.7	-0.1	0.6	-0.9	-1.1	-0.6	-1.0	-0.8
Age at First Birth	0.4	0.6	3.0	0.9	0.2	-0.1	-0.5	1.7	0.9	1.1	1.0	-0.2	0.4	0.4	0.1	0.8
Coronary Artery Disease (CAD)	0.4	0.4	1.3	-0.3	-0.6	0.5	-1.0	-0.3	-0.0	1.2	-0.4	1.0	0.3	0.5	0.3	1.0
Lupus	0.4	0.6	2.8	-0.0	1.7	1.0	1.2	-1.2	0.9	-0.9	-0.0	-0.1	-0.4	-0.1	-0.1	0.3
Triglycerides	0.4	0.6	3.4	-1.5	-0.4	-0.1	-0.4	-0.8	-1.9	-0.4	-1.0	-0.1	-0.5	0.1	-0.3	-0.2
Smoking Status	0.4	0.9	2.4	1.5	1.0	0.8	1.5	1.1	0.4	0.9	1.0	-0.1	0.1	-1.1	-0.5	0.5
Current tobacco smoking	0.4	0.6	1.7	1.1	1.3	1.1	1.2	0.3	0.1	-0.4	0.7	-0.2	0.1	-0.8	-0.6	0.8
Supplements: Glucosamine	0.4	0.5	2.3	-0.4	0.6	-0.3	0.7	1.1	0.7	1.5	0.3	0.3	-0.1	-0.5	-0.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.9	0.9	-0.1	-1.1	0.0	1.1	-2.0	0.2	0.2	0.6	-0.6	-0.7	-1.9	-0.6
Financial difficulties in last 2 years	0.4	0.6	3.1	0.9	-0.7	-0.2	0.1	0.5	-1.8	-1.4	0.4	-0.3	-0.2	-0.0	-0.4	-0.7
Illnesses of mother	0.4	0.5	2.1	-0.7	-0.1	1.0	-0.3	-1.5	0.1	-0.6	0.2	0.2	1.0	0.1	1.0	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.8	1.3	1.4	-0.7	0.4	1.5	1.6	0.3	1.7	-1.1	-1.1	-0.1	-1.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	3.1	-0.1	-0.5	1.8	-0.9	0.3	0.9	1.3	0.0	-0.2	1.2	0.2	0.5	0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	3.3	0.2	-0.7	1.1	0.4	0.4	-0.5	-0.3	-0.3	-0.3	0.8	0.0	0.4	1.8
Angina (self-reported)	0.4	0.5	1.6	-0.4	-0.2	0.5	-0.4	-0.7	-1.2	0.7	-0.1	1.3	-0.1	-1.2	-0.3	0.4
Medication: Ibuprofen	0.4	0.5	2.5	0.4	0.2	0.1	1.6	-0.2	-1.2	-0.6	0.7	0.6	-0.2	0.9	-0.4	0.0
Overall health rating	0.4	0.9	5.6	-0.7	-0.5	0.4	-0.6	-0.9	-0.2	-0.2	-0.5	1.2	0.6	2.4	1.0	0.7
Leg pain on walking	0.4	0.5	1.9	-0.8	0.2	-0.0	-0.4	1.0	-0.4	1.4	-0.8	0.1	0.0	1.1	0.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	3.5	-0.0	-0.5	-0.1	-0.0	-0.2	-0.0	-1.9	-0.3	-1.0	0.5	-0.0	0.7	0.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.5	0.3	1.1	-1.1	-0.2	0.5	0.5	0.6	0.4	-0.4	-0.9	-1.2	-0.6	-0.5
Smoking status: Previous	0.4	0.5	3.1	-0.6	-0.9	-0.4	0.2	0.6	0.1	1.8	-0.6	0.2	0.4	-0.9	0.6	-0.2
Loneliness, isolation	0.4	0.5	1.4	-0.7	-0.3	-0.2	-0.6	-1.2	-0.8	-1.1	-0.7	-0.4	-0.8	0.3	-0.2	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	2.1	0.5	0.3	-0.5	0.5	0.9	-1.0	0.4	0.4	0.2	-0.5	-0.3	-1.4	-0.5
High cholesterol (Self-reported)	0.4	0.7	2.9	-1.1	-0.0	0.6	-0.4	-1.1	-0.7	-0.2	-0.7	1.1	0.0	-1.7	0.1	0.9
Schizophrenia (2018)	0.3	0.6	2.4	-0.6	-1.3	-0.1	-1.6	-0.5	-0.1	-1.0	-0.9	-0.8	-0.0	-0.5	0.6	-0.0
Crohns Disease (2017)	0.3	0.6	1.8	-0.4	-1.1	-1.3	-0.8	-0.2	-0.0	0.2	-0.8	-0.7	-0.9	0.5	0.3	-1.2
LDL Cholesterol	0.3	0.5	2.2	-1.5	-0.0	0.2	-0.7	-0.7	-0.4	0.1	-1.2	0.8	-0.3	0.8	0.1	0.1
Blood Red Count	0.3	2.6	7.1	-2.7	-2.5	-0.3	-1.6	-1.4	-0.9	0.8	-2.4	1.9	-0.3	1.8	1.1	0.7
Chronotype (morning person)	0.3	0.8	3.5	-1.0	-1.9	0.3	-0.9	0.4	-1.4	-0.1	-0.7	0.7	0.8	0.1	1.0	0.5
Medication for hormone replacement therapy	0.3	0.4	1.2	1.0	-0.5	-0.2	0.2	1.1	-0.6	0.5	0.5	0.5	0.6	-0.6	-0.0	0.9
Relative age voice broke	0.3	0.5	2.5	0.4	1.0	-0.2	-0.4	-1.0	1.6	-0.2	0.7	-0.7	-0.1	0.2	0.4	-0.5
Taking other prescription medications	0.3	0.4	2.0	0.0	-0.4	-0.3	0.1	0.7	-1.4	-0.5	0.3	-0.6	-0.2	0.8	-0.9	0.3
Allergy	0.3	0.6	3.0	-0.9	0.1	0.4	-0.9	0.4	0.4	1.7	-0.2	0.8	0.7	-1.0	0.8	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.7	-0.0	1.1	-1.0	0.2	1.0	0.2	-0.7	0.4	-0.6	-1.6	0.4	-1.5	-0.7
Peak expiratory flow (PEF)	0.3	0.8	5.8	0.3	-0.2	-0.6	0.2	0.1	2.4	-0.5	-0.1	-1.0	-0.7	1.0	0.5	-0.6
Pulse wave reflection index	0.3	0.4	1.4	-0.6	-1.1	0.3	0.1	0.1	-0.1	0.6	-0.8	1.2	0.2	0.6	-0.5	0.5
Blood clot in the leg (DVT)	0.3	0.4	1.5	0.9	0.4	0.0	1.1	-0.3	0.4	-0.6	0.6	0.1	0.3	1.2	-0.1	0.1
High blood pressure (siblings)	0.3	0.4	1.3	0.6	-0.4	-0.4	1.1	1.2	0.3	0.4	0.3	-0.2	0.0	1.0	-0.4	-0.2
Forced vital capacity (FVC), Best measure	0.3	1.0	2.6	0.9	1.3	-0.6	0.7	1.2	0.8	0.1	1.3	-1.0	-1.4	-0.5	-1.6	-0.5
Comparative height size at age 10	0.3	1.6	6.7	0.0	0.2	1.2	-1.3	0.2	0.7	2.0	-0.2	2.6	1.8	-0.6	0.8	1.3
Chest pain or discomfort	0.3	0.5	1.4	0.9	0.9	-0.7	0.8	0.1	0.1	-0.4	0.9	0.2	-0.5	1.2	-0.5	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.7	0.4	0.1	0.6	0.1	0.7	0.5	1.3	0.5	0.2	0.2	1.0	-0.6	0.4
Illnesses of siblings: Diabetes	0.3	0.3	1.4	-0.6	-0.9	-0.8	1.2	0.1	-0.1	0.1	-0.6	-0.6	-0.4	0.3	0.4	-0.4
Medication for cholesterol	0.3	0.5	1.6	0.4	1.0	0.5	-0.3	0.5	1.2	-1.3	0.3	-1.1	0.3	-0.4	0.6	0.3
Number of self-reported non-cancer illnesses	0.3	0.5	3.3	0.7	0.2	-0.2	0.1	0.4	0.3	0.0	1.1	-0.1	0.6	1.8	-0.1	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.8	0.4	-1.3	0.5	-0.2	-0.2	-0.5	-0.3	-0.5	-0.0	0.9	-0.8	0.7	-0.6
Medication: Lisinopril	0.3	0.3	1.6	-0.3	-0.4	0.3	-0.9	1.3	-0.2	0.9	-0.1	0.1	-0.3	0.1	-0.4	-0.7
Age started oral contraceptive pill	0.3	0.4	1.4	0.5	0.5	-0.7	-0.0	-0.1	0.8	0.5	0.9	-1.0	-0.6	-1.2	-0.1	-0.3
Pain experienced in last month	0.3	0.4	1.5	-0.1	0.4	0.1	-1.2	-1.1	0.9	-0.5	-0.1	-0.9	-0.1	0.1	0.9	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.7	0.5	0.2	-0.3	1.0	-0.5	0.1	-0.9	0.3	-0.1	-0.1	1.3	-0.3	-0.2
Heart disease (siblings)	0.3	0.4	1.1	1.1	-0.7	-0.9	0.9	0.2	-0.0	-0.2	0.9	-0.4	-0.3	-0.0	-0.7	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.5	2.8	-0.9	-0.8	-0.1	-1.7	0.1	-0.2	0.2	-0.8	0.4	-0.0	-0.3	0.8	0.6
Schizophrenia (2014)	0.2	0.4	1.7	-0.1	-0.6	-0.5	-0.9	0.7	1.1	-0.7	-0.5	-1.3	-0.6	-0.2	0.2	-0.1
Blood White Count	0.2	1.6	5.1	0.3	0.6	-1.3	1.4	-1.0	-1.7	0.7	0.7	1.0	-1.9	-0.1	-2.3	-1.6
Height	0.2	2.9	12.5	1.7	1.4	-0.3	-0.1	1.7	1.6	2.7	1.8	1.4	0.7	-3.5	-1.3	0.6
Lung FEV1/FVC ratio	0.2	1.1	3.2	0.6	0.4	1.4	-1.3	0.6	0.4	1.2	0.8	1.8	1.3	-0.2	0.6	1.5
Diabetes (mother)	0.2	0.3	0.9	-0.2	-0.2	-0.6	-0.3	0.0	-0.5	-0.6	-0.9	0.0	-0.5	-0.9	-0.3	-0.7
Pack years adult smoking proportion	0.2	0.4	2.0	-0.5	-0.5	0.2	-0.5	0.5	-1.4	-0.4	-0.2	0.7	0.2	-0.8	-0.0	0.8
Maternal smoking around birth	0.2	0.3	1.0	0.9	-0.2	0.0	0.3	0.4	-1.0	-0.0	0.0	-0.2	0.4	-0.9	-0.8	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.1	0.3	0.3	-0.7	0.4	-0.6	0.1	-0.8	0.0	-1.0	-0.0	0.0	0.1	0.0
Stomach or abdominal pain in last month	0.2	0.3	1.1	-0.5	-0.6	-0.2	-0.5	0.8	0.1	1.0	-0.3	0.8	0.3	0.3	-0.2	0.3
Medication: Levothyroxine sodium	0.2	0.3	1.9	-0.2	-0.2	0.7	-0.6	0.3	1.4	0.6	0.3	-0.4	0.3	0.2	-0.0	0.2
Number of incorrect matches in round	0.2	0.4	3.0	0.2	0.0	0.1	-0.1	1.7	-0.9	0.4	0.3	-0.3	0.1	-0.5	-0.4	0.1
Father’s age at death	0.2	0.3	1.2	-0.5	0.3	0.3	-0.3	0.0	0.0	-1.1	-0.2	0.3	0.4	-1.0	0.6	0.8
Standing height	0.2	1.9	8.4	0.1	0.8	0.1	-1.0	0.8	0.3	2.9	0.6	2.5	0.9	-2.3	-0.6	0.7
Loud music exposure frequency	0.2	0.2	0.9	0.4	0.4	1.0	-0.3	-0.2	-0.4	0.3	0.5	0.6	0.5	-0.4	0.4	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.8	-0.3	-0.9	-0.0	-0.1	0.5	-1.3	-0.3	-0.7	-0.1	0.3	-0.2	0.0	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.9	-0.4	-0.0	0.3	1.0	-0.1	-0.1	0.4	-0.4	0.2	-0.8	-0.9	-0.2	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.7	-0.0	0.2	-0.0	-0.4	-0.4	0.4	1.3	0.1	0.7	0.0	0.6	0.3	0.6
Pulse rate, automated reading	0.2	0.8	2.1	0.3	-0.4	-0.6	0.8	0.3	-1.5	-1.2	0.5	-1.1	-0.8	-1.4	0.3	-1.1
Average weekly red wine intake	0.2	0.2	1.0	-0.1	-0.0	-0.2	0.2	1.0	0.2	0.8	0.7	-0.6	-0.6	-0.1	-0.1	-0.2
Osteoarthritis (self-reported)	0.2	0.3	1.2	-0.4	0.1	-0.5	0.8	-0.5	-1.1	0.0	-0.5	0.6	-0.4	0.1	-0.3	-0.3
Supplements: Calcium	0.2	0.2	0.8	-0.1	0.4	-0.7	0.1	0.3	-0.4	0.3	0.4	-0.1	-0.9	0.8	-0.1	-0.7
Pack years of smoking	0.2	0.3	1.2	-0.4	-0.3	0.2	-0.5	0.5	-0.9	-0.3	-0.0	0.5	0.3	-1.1	0.3	0.8
Mean Putamen Volume	0.1	0.1	0.4	0.3	-0.0	-0.1	0.4	0.4	0.7	0.2	0.2	0.0	0.3	0.1	-0.3	0.0
Blood Eosinophil Count	0.1	0.9	3.0	-1.2	-0.5	-0.1	-0.3	-1.4	-1.7	0.8	-0.9	1.6	-0.2	-0.4	-0.2	-0.5
Tanning	0.1	0.8	3.6	0.1	-0.5	-1.1	-0.2	1.1	-1.9	-0.5	0.3	0.6	-1.1	-1.4	-0.4	-0.7
Past tobacco smoking	0.1	0.3	1.3	0.4	0.5	-0.3	-0.3	-0.0	-0.2	-1.1	0.2	-0.0	-0.9	0.7	-0.7	0.0
Birth weight	0.1	0.2	0.8	0.9	0.1	-0.4	-0.6	-0.5	0.3	-0.2	0.5	-0.4	-0.0	-0.8	-0.3	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.5	0.2	-0.3	-0.3	-0.4	0.4	0.5	0.3	0.0	-0.1	-0.2	-0.7	-0.3	-0.2
Medication: Gliclazide	0.1	0.1	0.3	0.5	0.1	0.6	0.4	0.0	0.2	-0.3	-0.0	0.3	0.4	-0.4	-0.0	0.4
Ever smoked	0.1	0.1	0.4	-0.6	-0.3	0.1	0.2	-0.5	-0.3	0.0	-0.4	-0.2	-0.0	-0.2	0.1	-0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.4	1.3	0.2	-0.1	0.3	0.6	1.1	0.1	-0.3	-0.8	-0.8	-0.7	0.1	-1.1	-0.1
Hair Pigment	0.0	1.3	2.9	1.6	-0.1	-1.5	1.1	1.2	-0.6	-0.0	1.0	-1.1	-1.0	1.2	-1.3	-1.7

Hub : Genes

FGD4

Models

Trait associations