Hub : Genes

FGD4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1200	0.0280	8.4e-11	0.076	0.096	0.107	0.095	0.108	1.4e-09	1.1e-11	5.5e-13	1.3e-11	5.0e-13
2	GTEx	Brain Nucleus accumbens basal ganglia	0.2940	0.0910	1.6e-03	0.052	NA	0.046	NA	0.051	1.6e-02	NA	2.2e-02	NA	1.8e-02
3	GTEx	Esophagus Mucosa	0.1050	0.0440	8.3e-03	0.129	NA	0.111	NA	0.122	5.8e-09	NA	7.0e-08	NA	1.5e-08
4	GTEx	Heart Left Ventricle	0.1869	0.0649	4.0e-03	0.028	NA	0.046	NA	0.029	1.2e-02	NA	1.7e-03	NA	1.0e-02
5	GTEx	Lung	0.0824	0.0330	2.8e-03	0.050	NA	0.038	NA	0.025	1.1e-04	NA	6.4e-04	NA	4.6e-03
6	GTEx	Skin Sun Exposed Lower leg	0.1110	0.0420	2.5e-03	0.000	NA	0.017	NA	0.008	3.1e-01	NA	1.3e-02	NA	6.4e-02
7	GTEx	Thyroid	0.1240	0.0470	2.6e-03	0.013	NA	0.035	NA	0.054	3.3e-02	NA	1.0e-03	NA	5.6e-05
8	ROSMAP	Brain Pre-frontal Cortex	0.0525	0.0198	1.0e-03	0.030	0.008	0.026	0.011	0.026	9.1e-05	2.6e-02	2.2e-04	1.1e-02	2.0e-04
9	YFS	Blood	0.0253	0.0103	6.4e-04	0.008	0.007	0.007	0.008	0.009	8.4e-04	1.3e-03	1.8e-03	8.3e-04	5.6e-04
10	TCGA	Breast Invasive Carcinoma	0.2228	0.0506	1.5e-09	0.095	0.071	0.105	NA	0.102	9.8e-19	2.0e-14	8.3e-21	NA	3.7e-20
11	TCGA	Esophageal Carcinoma	0.2280	0.0830	1.1e-03	0.047	0.040	0.008	NA	0.077	1.3e-02	2.0e-02	1.7e-01	NA	2.0e-03
12	TCGA	Head and Neck Squamous Cell Carcinoma	0.1788	0.0625	1.5e-06	0.038	0.073	0.080	NA	0.086	3.9e-05	1.4e-08	2.5e-09	NA	7.3e-10
13	TCGA	Thyroid Carcinoma	0.3110	0.0760	2.1e-07	0.151	0.122	0.173	NA	0.158	1.5e-14	6.3e-12	1.5e-16	NA	3.8e-15

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.4	0.6	2.6	-0.7	0.3	-0.1	-0.7	0.7	-0.3	1.6	-0.1	1.6	0.0	0.1	0.6	1.0
Bipolar Disorder or Schizophrenia	0.2	0.5	2.8	-0.9	-0.8	-0.1	-1.7	0.1	-0.2	0.2	-0.8	0.4	-0.0	-0.3	0.8	0.6
Depressed Affect (Nagel 2018)	2.7	5.8	19.2	-0.5	-0.2	-4.4	1.1	-0.5	-2.4	-1.4	0.0	-2.7	-4.1	1.1	-2.7	-3.6
Depression (Nagel 2018)	0.6	0.9	2.4	-1.5	-0.5	-1.2	-1.0	-0.4	-1.1	-0.4	-1.0	0.8	-1.6	0.7	-0.4	-0.6
Intelligence (Savage-Jansen 2018)	0.4	1.4	5.8	1.4	-0.1	-0.7	-1.0	-0.5	2.4	-1.7	0.8	-1.3	-0.2	1.4	0.7	-0.6
Neuroticism (Nagel 2018)	1.9	4.6	16.5	-1.5	-0.4	-3.4	-0.3	-0.2	-2.6	-1.3	-1.1	-1.3	-4.1	0.6	-2.6	-3.3
Schizophrenia (2018)	0.3	0.6	2.4	-0.6	-1.3	-0.1	-1.6	-0.5	-0.1	-1.0	-0.9	-0.8	-0.0	-0.5	0.6	-0.0
Schizophrenia vs Biploar Disorder	1.0	1.3	6.4	1.1	-0.7	-0.8	0.3	-0.2	1.2	-2.5	-0.2	-2.0	-0.4	0.5	0.2	-1.5
Worry (Nagel 2018)	0.8	1.8	6.8	-0.8	-0.2	-1.9	-0.4	-0.6	-1.2	-1.4	-1.0	0.0	-2.6	0.5	-1.4	-2.1
Alzheimer’s Disease (in mother)	0.8	0.9	2.9	-1.0	-1.7	-0.9	-0.7	-0.8	-0.9	-0.2	-1.1	0.6	0.7	-0.3	1.2	-1.1
Alzheimer’s Disease (in father)	0.6	0.6	1.8	-1.1	-0.3	-0.5	-0.8	-1.0	0.0	0.6	-0.6	0.1	-1.0	-0.8	0.5	-1.4
Alzheimer’s Disease (including proxy)	1.0	1.4	4.3	-1.5	-2.1	-0.9	-1.0	-1.0	-0.8	0.4	-1.5	0.8	-0.1	-1.2	1.2	-1.6
Crohns Disease (2017)	0.3	0.6	1.8	-0.4	-1.1	-1.3	-0.8	-0.2	-0.0	0.2	-0.8	-0.7	-0.9	0.5	0.3	-1.2
Irritable Bowel Disease (IBD)	0.4	0.9	3.2	0.4	-0.4	-1.7	0.1	0.3	-1.0	0.2	0.4	-0.3	-1.8	-0.2	-1.2	-1.3
Ulcerative Colitis (UC)	0.5	1.0	3.2	0.7	0.4	-1.1	0.8	0.2	-1.3	0.2	1.1	0.0	-1.7	-0.1	-1.8	-1.0
Major Depression (MDD)	0.5	0.7	3.9	-0.7	-0.4	-0.7	-0.2	-1.0	-0.3	-2.0	-0.8	-1.0	-0.5	0.6	0.0	0.4
Reaction Time	1.4	2.7	7.3	0.9	0.7	2.5	0.1	1.1	0.3	2.6	1.0	2.3	2.7	0.6	0.9	2.0
Verbal and Numeric Reasoning (VNR)	0.8	1.8	5.6	1.4	1.0	-1.6	0.1	-0.2	2.1	-1.5	1.0	-2.4	-1.4	-0.6	-0.9	-1.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.4	0.5	1.3	0.4	0.2	-1.0	0.5	0.1	-0.7	-0.1	0.6	-0.9	-1.1	-0.6	-1.0	-0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.6	3.0	0.9	0.2	-0.1	-0.5	1.7	0.9	1.1	1.0	-0.2	0.4	0.4	0.1	0.8
Bipolar Disorder (2011)	0.5	0.4	1.1	0.7	0.8	0.2	0.4	0.6	0.3	1.0	0.7	0.9	-0.2	-0.3	-0.6	1.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.1	-0.2	0.5	1.5	-1.0	-0.7	1.1	-0.1	-0.0	0.8	0.8	0.7	0.8	1.2
Coronary Artery Disease (CAD)	0.4	0.4	1.3	-0.3	-0.6	0.5	-1.0	-0.3	-0.0	1.2	-0.4	1.0	0.3	0.5	0.3	1.0
Crohns Disease (2012)	0.8	1.2	3.2	-1.0	-1.7	-0.3	-1.6	-1.6	0.3	-0.6	-1.8	-0.0	-0.8	0.7	0.9	-1.1
Mean Putamen Volume	0.1	0.1	0.4	0.3	-0.0	-0.1	0.4	0.4	0.7	0.2	0.2	0.0	0.3	0.1	-0.3	0.0
Fasting Glucose	1.6	1.9	4.7	1.5	0.8	-1.6	1.5	0.6	-1.2	-0.5	1.9	1.6	-1.0	1.5	-2.2	-0.9
HbA1C	0.6	0.6	2.1	0.4	0.4	1.4	-0.4	0.1	0.0	1.2	0.5	1.2	0.7	1.4	-0.2	0.4
HDL Cholesterol	1.4	2.3	6.5	2.5	1.9	-0.4	1.7	1.8	1.7	0.3	1.6	-2.2	-0.5	-0.3	-1.7	-0.7
LDL Cholesterol	0.3	0.5	2.2	-1.5	-0.0	0.2	-0.7	-0.7	-0.4	0.1	-1.2	0.8	-0.3	0.8	0.1	0.1
Lupus	0.4	0.6	2.8	-0.0	1.7	1.0	1.2	-1.2	0.9	-0.9	-0.0	-0.1	-0.4	-0.1	-0.1	0.3
Neuroticism (2016)	1.8	2.5	8.2	-0.7	0.1	-1.9	1.0	0.2	-2.1	-1.4	-0.6	-0.8	-2.9	1.7	-2.5	-1.9
Primary Biliary Cirrhosis	0.9	1.3	3.6	-1.1	-0.5	1.9	-0.3	-1.1	0.5	0.6	-0.6	1.0	1.7	1.2	1.5	1.5
Rheumatoid Arthritis	1.0	1.4	3.6	-1.9	-0.4	1.4	-1.7	-0.4	-0.9	0.8	-1.5	1.2	0.3	-1.9	-0.0	0.9
Schizophrenia (2014)	0.2	0.4	1.7	-0.1	-0.6	-0.5	-0.9	0.7	1.1	-0.7	-0.5	-1.3	-0.6	-0.2	0.2	-0.1
Triglycerides	0.4	0.6	3.4	-1.5	-0.4	-0.1	-0.4	-0.8	-1.9	-0.4	-1.0	-0.1	-0.5	0.1	-0.3	-0.2
Type 2 Diabetes (T2D) (2012)	0.9	1.1	3.0	-0.5	0.4	-1.6	-0.8	-0.8	0.6	-0.9	-0.9	-1.3	-1.3	-0.3	-1.1	-1.7
Ulcerative Colitis	0.5	0.7	2.6	-0.6	-1.0	-0.8	-1.6	-0.7	-1.1	-0.9	-0.4	0.5	-0.8	0.5	-0.1	-0.8
Blood Eosinophil Count	0.1	0.9	3.0	-1.2	-0.5	-0.1	-0.3	-1.4	-1.7	0.8	-0.9	1.6	-0.2	-0.4	-0.2	-0.5
Blood Platelet Count	0.9	10.5	28.1	-2.5	-0.7	-4.3	0.7	-4.1	-5.3	-2.8	-2.0	-0.7	-5.1	1.1	-3.6	-3.6
Blood Red Count	0.3	2.6	7.1	-2.7	-2.5	-0.3	-1.6	-1.4	-0.9	0.8	-2.4	1.9	-0.3	1.8	1.1	0.7
Blood White Count	0.2	1.6	5.1	0.3	0.6	-1.3	1.4	-1.0	-1.7	0.7	0.7	1.0	-1.9	-0.1	-2.3	-1.6
Heel T-Score	0.0	0.4	1.3	0.2	-0.1	0.3	0.6	1.1	0.1	-0.3	-0.8	-0.8	-0.7	0.1	-1.1	-0.1
BMI	1.3	7.7	26.6	-2.5	-3.2	2.9	-2.3	-0.3	-0.8	2.0	-2.2	5.2	3.8	0.1	3.1	2.9
Height	0.2	2.9	12.5	1.7	1.4	-0.3	-0.1	1.7	1.6	2.7	1.8	1.4	0.7	-3.5	-1.3	0.6
Waist Hip Ratio (WHR)	1.1	4.8	14.9	1.3	-0.3	-3.9	1.7	-2.0	1.1	-2.7	-0.0	-2.8	-2.7	0.9	-1.8	-3.2
Systolic Blood Pressure	1.1	5.3	24.3	-2.8	-2.8	-0.8	-1.8	-3.0	-0.9	-1.0	-3.1	0.5	0.1	4.9	2.0	-0.6
Smoking Status	0.4	0.9	2.4	1.5	1.0	0.8	1.5	1.1	0.4	0.9	1.0	-0.1	0.1	-1.1	-0.5	0.5
Allergy or Eczema	0.5	1.3	3.5	1.7	1.1	-0.8	1.2	-0.3	1.5	-1.8	0.7	-1.9	-0.3	1.0	-0.3	-0.2
Cardiovascular Disease	0.9	3.0	6.9	-2.6	-2.6	0.5	-1.2	-1.4	-2.0	0.7	-1.9	2.3	0.6	2.6	1.0	0.5
Hypothyroidism (self reported)	0.5	1.1	5.4	-0.0	-0.5	2.3	-0.7	0.3	1.5	1.4	-0.0	-0.1	1.5	-0.4	1.0	1.0
Respiratory disease	0.6	1.4	3.7	1.3	1.9	-0.9	1.6	0.0	-0.8	-1.5	1.4	-1.5	-0.9	0.2	-1.3	-0.3
Type 2 Diabetes (T2D) (2018)	1.1	2.1	6.2	0.1	-0.5	1.6	-0.5	-0.1	2.0	0.9	0.1	1.6	2.5	1.6	2.1	2.0
Lung FEV1/FVC ratio	0.2	1.1	3.2	0.6	0.4	1.4	-1.3	0.6	0.4	1.2	0.8	1.8	1.3	-0.2	0.6	1.5
Lung FVC	0.5	2.8	12.0	0.7	0.5	-1.9	2.0	-0.1	0.1	-2.2	0.8	-3.5	-2.3	-1.3	-1.4	-1.4
Neuroticism	2.4	5.8	22.4	-0.5	0.1	-3.9	1.0	0.4	-2.8	-0.9	-0.2	-1.1	-4.7	1.0	-3.4	-3.8
Chronotype (morning person)	0.3	0.8	3.5	-1.0	-1.9	0.3	-0.9	0.4	-1.4	-0.1	-0.7	0.7	0.8	0.1	1.0	0.5
Hair Pigment	0.0	1.3	2.9	1.6	-0.1	-1.5	1.1	1.2	-0.6	-0.0	1.0	-1.1	-1.0	1.2	-1.3	-1.7
Tanning	0.1	0.8	3.6	0.1	-0.5	-1.1	-0.2	1.1	-1.9	-0.5	0.3	0.6	-1.1	-1.4	-0.4	-0.7
Hand grip strength (left)	1.3	3.5	10.3	1.1	-0.2	-3.2	1.8	-0.9	1.7	-1.3	0.1	-2.9	-2.1	-0.4	-1.6	-3.2
Number of treatments/medications taken	0.5	0.9	4.3	-0.2	-0.8	-1.1	0.6	-0.6	-1.4	-1.0	-0.0	-0.8	-0.6	2.1	-0.5	-0.7
Average weekly spirits intake	1.0	1.2	3.2	-1.8	-1.3	1.0	-0.9	0.3	-1.5	1.4	-1.2	1.4	0.7	-0.5	0.5	0.8
Sensitivity / hurt feelings	0.8	1.4	3.8	-1.9	-1.6	-0.4	-1.3	-1.1	-1.5	-0.6	-1.9	1.2	-0.5	0.6	0.2	-0.1
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.5	-1.9	-1.0	-0.9	-1.6	-1.6	-1.5	-0.5	-1.3	1.1	-1.4	0.9	-0.1	-1.2
Hearing difficulty/problems: Yes	1.8	2.7	8.7	-0.2	0.3	1.7	-0.5	2.0	-1.1	2.4	0.6	2.9	1.7	-1.8	-0.3	2.4
Relative age of first facial hair	1.1	2.3	8.8	2.4	2.3	-1.2	1.5	0.3	1.9	-0.1	3.0	-1.2	-0.3	0.3	-0.9	0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.8	1.5	1.8	0.2	0.5	1.3	1.2	0.3	1.9	-0.4	0.2	0.6	-0.9	0.4
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.8	1.1	-0.4	-1.7	1.6	-1.1	-0.4	-1.4	0.4	-1.6	-1.2	-0.9	-1.0	-0.9
Ever had hysterectomy (womb removed)	0.7	0.8	3.1	0.5	1.4	1.0	0.1	0.9	0.2	0.9	0.8	0.2	1.2	-0.0	-0.0	1.8
Systolic blood pressure, automated reading	1.0	3.0	7.7	-2.3	-2.5	-0.9	-2.0	-2.2	-0.8	-1.5	-2.8	0.8	0.4	1.6	2.0	-0.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	6.2	0.3	-0.5	-0.1	-0.7	-1.0	-0.0	0.3	0.0	1.6	0.3	-2.5	0.2	-0.4
Angina	0.5	0.6	2.1	-0.4	-0.1	0.7	-0.4	-0.5	-1.1	0.9	0.0	1.4	0.1	-1.5	-0.3	0.6
Medication for hormone replacement therapy	0.3	0.4	1.2	1.0	-0.5	-0.2	0.2	1.1	-0.6	0.5	0.5	0.5	0.6	-0.6	-0.0	0.9
Vitamin and mineral supplements	0.6	0.8	2.8	-0.2	-0.7	1.4	-0.8	0.1	-1.6	0.5	0.1	0.4	0.9	-1.7	0.1	0.7
Supplements: Zinc	1.0	1.1	3.4	0.5	0.4	-0.8	1.8	0.8	-0.6	-0.3	-0.0	-1.3	-1.6	-0.3	-1.8	-1.2
Medication: Co-codamol	1.0	1.1	3.8	-1.5	-1.9	0.4	-1.0	-1.5	-0.9	-0.9	-1.2	0.4	-0.1	0.5	1.0	-0.8
Medication: Metformin	0.5	0.7	1.9	0.1	-0.4	0.4	-0.4	-1.2	1.0	0.0	-0.4	1.4	1.0	0.9	1.4	1.0
Diabetes (father)	1.1	1.4	4.4	-2.1	-0.7	0.2	-1.9	0.1	-1.7	0.1	-1.1	2.1	-0.7	0.3	0.6	0.3
Diabetes (mother)	0.2	0.3	0.9	-0.2	-0.2	-0.6	-0.3	0.0	-0.5	-0.6	-0.9	0.0	-0.5	-0.9	-0.3	-0.7
Severe depression (siblings)	0.6	0.7	2.9	-0.4	-0.1	-0.4	-0.8	-0.9	1.7	-0.3	-0.6	-0.3	0.8	-0.4	1.7	0.4
Pack years adult smoking proportion	0.2	0.4	2.0	-0.5	-0.5	0.2	-0.5	0.5	-1.4	-0.4	-0.2	0.7	0.2	-0.8	-0.0	0.8
Impedance of leg (right)	0.7	3.5	14.7	0.8	1.2	-2.6	1.2	-0.0	0.4	-1.3	0.8	-3.8	-2.9	0.4	-2.2	-2.3
Leg fat-free mass (left)	1.3	6.7	29.2	-2.1	-2.7	2.3	-3.1	-0.6	-0.7	2.4	-1.9	5.4	3.3	-0.7	2.4	2.0
Trunk fat percentage	1.1	4.5	11.3	-3.2	-3.3	0.1	-2.9	-2.0	-1.1	0.2	-3.4	2.6	1.2	1.2	1.7	0.5
Hand grip strength (right)	0.8	2.0	6.1	1.1	0.2	-2.2	1.2	-1.2	2.1	-1.0	0.7	-1.9	-1.1	0.1	-0.8	-2.5
Townsend deprivation index at recruitment	3.7	5.2	10.8	-2.8	-3.0	2.7	-1.5	-2.4	-1.8	-0.4	-3.3	3.0	2.2	-0.2	2.3	1.5
Current tobacco smoking	0.4	0.6	1.7	1.1	1.3	1.1	1.2	0.3	0.1	-0.4	0.7	-0.2	0.1	-0.8	-0.6	0.8
Average weekly fortified wine intake	1.0	1.2	2.9	0.3	0.8	-1.6	0.8	0.8	-0.6	-0.8	0.7	-1.7	-1.6	-0.3	-1.7	-1.3
Maternal smoking around birth	0.2	0.3	1.0	0.9	-0.2	0.0	0.3	0.4	-1.0	-0.0	0.0	-0.2	0.4	-0.9	-0.8	-0.4
Fed-up feelings	1.9	3.5	10.1	0.4	-0.1	-3.2	-0.0	-0.3	-2.1	-1.4	0.9	-2.2	-2.9	0.9	-2.0	-3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	-0.8	-0.3	-0.7	-0.6	-0.3	-1.5	-1.0	-0.0	0.3	-1.1	1.1	-0.7	-0.9
Relative age voice broke	0.3	0.5	2.5	0.4	1.0	-0.2	-0.4	-1.0	1.6	-0.2	0.7	-0.7	-0.1	0.2	0.4	-0.5
Taking other prescription medications	0.3	0.4	2.0	0.0	-0.4	-0.3	0.1	0.7	-1.4	-0.5	0.3	-0.6	-0.2	0.8	-0.9	0.3
Age when periods started (menarche)	1.1	2.7	8.2	1.7	0.2	-1.8	1.0	0.8	0.6	-1.0	1.2	-2.1	-2.1	-0.9	-2.9	-2.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.1	0.3	0.3	-0.7	0.4	-0.6	0.1	-0.8	0.0	-1.0	-0.0	0.0	0.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.7	1.6	0.6	-1.2	0.4	1.0	-0.5	-1.3	1.2	-0.8	-0.8	-0.2	-1.6	-1.3
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	5.2	-0.0	1.1	1.3	1.1	1.6	0.6	2.3	0.0	1.0	1.0	-2.0	0.1	1.7
Qualifications: CSEs or equivalent	0.5	0.7	3.4	-0.2	-0.9	0.8	-0.5	0.6	-1.8	0.4	-0.5	1.3	0.3	0.4	-0.8	0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.8	1.0	1.3	0.6	0.2	1.0	0.8	-0.5	1.3	-0.8	0.3	0.2	-0.1	0.6
High blood pressure	0.8	2.3	10.8	-1.6	-2.5	0.6	-1.4	-0.2	-1.6	0.8	-1.1	1.8	0.6	3.3	1.0	0.3
Hayfever, allergic rhinitis or eczema	0.5	1.0	3.7	1.4	0.2	-0.5	0.8	-0.3	1.2	-1.6	0.5	-1.4	-0.4	1.9	-0.3	-0.6
Multivitamins +/- minerals	0.5	0.6	2.2	-0.7	0.0	-0.7	0.2	-1.0	1.0	0.1	-0.6	1.3	-0.5	1.5	0.5	-0.4
Stomach or abdominal pain in last month	0.2	0.3	1.1	-0.5	-0.6	-0.2	-0.5	0.8	0.1	1.0	-0.3	0.8	0.3	0.3	-0.2	0.3
Supplements: Glucosamine	0.4	0.5	2.3	-0.4	0.6	-0.3	0.7	1.1	0.7	1.5	0.3	0.3	-0.1	-0.5	-0.1	1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.7	1.0	1.0	-0.4	0.3	0.9	0.7	0.7	1.0	-1.6	-0.1	-0.4	-0.1	-0.6
Medication: Atenolol	0.6	0.8	3.0	-1.1	-0.6	-1.2	-0.2	0.2	-1.1	1.7	-0.5	0.8	-0.6	1.1	-0.0	-0.5
Medication: Levothyroxine sodium	0.2	0.3	1.9	-0.2	-0.2	0.7	-0.6	0.3	1.4	0.6	0.3	-0.4	0.3	0.2	-0.0	0.2
Sitting height	0.6	4.3	17.2	-1.3	0.2	2.4	-1.9	0.7	-0.2	3.1	-0.6	4.2	2.1	-1.8	0.7	3.0
Chronic bronchitis/emphysema (father)	1.6	1.8	6.0	-0.8	-1.6	1.5	0.4	-0.3	0.7	1.4	-0.8	1.2	2.4	-1.0	2.1	1.3
High blood pressure (mother)	0.8	1.1	3.6	1.3	0.1	-1.0	0.5	1.3	0.8	0.5	0.5	-1.0	-0.9	1.9	-0.9	-1.3
Body mass index (BMI)	2.0	8.5	20.9	-3.4	-4.1	2.3	-3.5	-1.7	-1.4	1.0	-3.3	4.6	3.2	0.8	3.3	2.0
Impedance of leg (left)	1.0	4.7	17.7	1.2	2.1	-2.8	1.8	-0.1	0.5	-1.2	1.3	-4.2	-3.2	0.4	-2.7	-2.2
Leg predicted mass (left)	1.3	6.9	29.8	-2.1	-2.7	2.4	-3.1	-0.6	-0.7	2.4	-2.0	5.5	3.4	-0.7	2.4	2.1
Trunk fat mass	1.4	5.9	15.5	-3.2	-3.4	1.0	-3.3	-1.7	-1.0	1.1	-3.1	3.9	2.3	0.7	2.2	1.3
Waist circumference	1.2	4.6	12.9	-2.8	-3.6	0.5	-2.4	-2.0	-1.0	0.5	-2.8	3.3	1.7	0.6	2.1	0.5
Number of incorrect matches in round	0.2	0.4	3.0	0.2	0.0	0.1	-0.1	1.7	-0.9	0.4	0.3	-0.3	0.1	-0.5	-0.4	0.1
Past tobacco smoking	0.1	0.3	1.3	0.4	0.5	-0.3	-0.3	-0.0	-0.2	-1.1	0.2	-0.0	-0.9	0.7	-0.7	0.0
Alcohol usually taken with meals	0.8	1.3	5.7	0.9	1.8	-0.2	0.2	2.4	0.8	1.1	1.7	-0.7	-0.8	0.0	-1.0	0.2
Nervous feelings	0.7	1.3	3.1	-1.7	-1.3	0.7	-1.5	-1.5	-1.1	-0.4	-1.6	1.8	-0.5	0.5	0.6	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.6	-1.6	-1.6	-1.8	-1.2	-0.3	-2.1	-1.2	-1.4	0.3	-1.6	0.5	-0.1	-1.1
Hearing difficulty/problems with background noise	0.8	1.3	4.6	1.5	0.9	0.2	0.3	2.1	-0.6	1.3	1.8	1.2	0.8	-0.7	-1.3	0.4
Hair/balding pattern: Pattern 2	1.2	1.6	7.2	0.9	0.5	-1.4	0.7	0.5	-0.2	-0.7	0.5	-1.3	-1.9	-0.4	-1.8	-2.7
Had menopause	0.7	0.8	2.9	-0.3	0.0	-1.2	0.9	-1.1	0.1	-0.2	-0.6	-1.7	-1.2	-1.5	-0.4	-0.7
Had other major operations	0.6	0.7	2.1	-0.9	0.2	-0.4	-1.5	-1.3	1.1	-1.1	-1.0	0.3	0.2	0.3	1.0	-0.2
Forced vital capacity (FVC)	0.6	2.5	6.4	1.7	0.9	-1.8	1.7	1.0	1.3	-0.9	1.5	-2.5	-1.8	-0.3	-1.9	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.9	0.9	-0.1	-1.1	0.0	1.1	-2.0	0.2	0.2	0.6	-0.6	-0.7	-1.9	-0.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	6.0	0.0	-0.0	-1.5	0.0	-0.5	-0.6	-2.5	-0.4	-1.5	-1.3	1.7	-0.7	0.3
Qualifications: None of the above	1.3	2.7	5.4	-2.2	-2.1	0.7	-0.4	-2.0	-2.1	1.7	-2.0	2.3	0.3	-1.9	0.3	-0.9
Financial difficulties in last 2 years	0.4	0.6	3.1	0.9	-0.7	-0.2	0.1	0.5	-1.8	-1.4	0.4	-0.3	-0.2	-0.0	-0.4	-0.7
Mouth/teeth dental problems	1.7	2.6	9.6	0.8	1.7	2.4	0.2	0.5	3.1	0.1	1.1	0.3	2.5	-0.3	1.5	2.0
Heart attack	0.8	1.1	3.8	-0.8	-0.8	1.5	-1.5	-0.9	-0.8	0.8	-0.2	2.0	1.1	-0.1	0.4	0.9
Allergy	0.3	0.6	3.0	-0.9	0.1	0.4	-0.9	0.4	0.4	1.7	-0.2	0.8	0.7	-1.0	0.8	0.4
Pain all over the body in last month	1.4	1.5	3.6	-1.0	-1.8	-0.9	-1.3	-1.8	-0.7	-1.9	-1.7	0.0	-0.7	0.1	0.4	-1.4
Diabetes (self-reported)	1.0	1.5	4.8	0.9	0.6	1.2	-0.5	-0.7	2.2	0.2	0.9	0.9	1.8	1.1	1.6	1.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.6	-0.6	-1.1	-0.9	-0.7	-0.5	-0.7	-1.1	-1.3	-1.1	-1.1	1.2	-0.9	-0.7
Medication: Ramipril	0.5	0.6	2.6	0.5	-0.4	1.0	0.8	-0.1	0.2	-0.0	-0.2	0.2	1.0	1.5	0.3	1.6
Medication: Simvastatin	1.9	2.8	7.5	-1.9	-1.3	2.4	-1.1	-1.3	-0.5	1.3	-1.0	2.7	1.8	-0.4	1.9	2.3
Fluid intelligence score	0.8	1.6	6.3	0.9	0.6	-0.9	-0.8	-1.0	2.0	-2.5	0.5	-2.2	-0.9	0.2	-0.2	-1.0
Illnesses of siblings	0.8	1.1	3.4	-0.3	0.6	1.6	-1.8	-0.8	0.2	-0.4	-0.5	1.5	0.9	-1.4	0.8	1.1
Neuroticism score	2.8	5.9	20.7	-0.5	-0.2	-3.7	0.4	-0.4	-2.6	-2.3	-0.4	-1.5	-4.5	1.2	-3.2	-3.9
Weight	1.8	9.0	31.7	-3.2	-3.5	2.4	-3.8	-1.2	-1.3	2.4	-2.8	5.6	3.6	-0.2	2.9	2.3
Impedance of arm (right)	1.2	5.6	19.7	2.2	2.3	-3.1	2.4	0.4	1.0	-2.0	1.4	-4.4	-2.9	0.6	-2.9	-2.0
Arm fat percentage (right)	1.6	6.1	16.8	-3.1	-4.1	0.9	-3.1	-1.9	-1.6	-0.3	-3.5	3.1	2.1	1.8	2.3	1.2
Trunk fat-free mass	1.0	5.8	28.2	-1.5	-1.7	2.2	-3.0	-0.4	-0.5	2.6	-0.8	5.3	3.2	-1.2	2.1	2.1
Hip circumference	1.9	8.2	22.7	-4.1	-3.7	1.8	-4.0	-1.4	-2.0	1.7	-3.2	4.8	2.5	-0.5	2.6	1.7
Time employed in main current job	0.5	0.5	3.4	-0.1	-0.3	-0.4	1.3	0.1	-1.8	0.4	0.2	0.0	-0.4	-0.6	-0.6	-0.3
Alcohol intake versus 10 years previously	0.5	0.8	3.8	-0.6	-0.3	0.0	-0.9	-1.2	-1.4	1.1	-0.5	1.9	0.2	0.5	-0.1	0.1
Father’s age at death	0.2	0.3	1.2	-0.5	0.3	0.3	-0.3	0.0	0.0	-1.1	-0.2	0.3	0.4	-1.0	0.6	0.8
Worrier / anxious feelings	0.7	1.3	5.1	0.1	0.7	-1.3	0.7	0.4	-1.1	-1.1	0.3	-0.1	-2.2	1.2	-1.6	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	5.8	0.1	-0.3	-1.9	0.4	-0.6	-2.4	-2.3	0.3	-1.1	-2.4	1.9	-1.4	-2.3
Falls in the last year	0.7	0.9	3.2	-0.0	0.1	0.4	-1.0	0.3	0.8	-0.1	0.1	0.8	1.6	1.5	1.8	1.0
Hair/balding pattern: Pattern 3	1.0	1.5	5.2	-0.0	0.4	1.4	-1.3	1.2	-0.5	0.8	0.7	1.5	1.8	-1.8	0.4	2.3
Number of live births	2.8	3.9	13.2	-0.6	0.4	3.6	-0.5	-0.3	1.4	2.3	-0.1	2.6	2.9	-0.4	2.5	2.7
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.7	1.9	1.1	-1.4	1.2	1.2	1.7	-0.6	1.8	-1.9	-1.3	0.2	-1.3	-1.1
Pulse rate	1.3	2.2	7.6	0.5	0.7	-1.3	0.9	2.8	-2.2	0.3	0.4	-0.4	-2.1	-2.0	-1.8	-1.0
Happiness	1.1	1.3	4.2	1.0	2.1	-0.2	1.5	1.2	0.4	1.3	1.7	-0.7	-0.7	-0.3	-1.3	-0.1
Noisy workplace	1.1	1.3	8.1	-0.3	0.2	-0.5	-0.6	0.0	-2.0	0.8	-0.2	1.2	-0.2	-2.8	-1.4	-0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.7	-0.0	1.1	-1.0	0.2	1.0	0.2	-0.7	0.4	-0.6	-1.6	0.4	-1.5	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	4.7	-1.9	-2.2	0.2	-1.1	-1.4	-0.9	-0.9	-2.1	0.7	-0.2	1.5	0.3	-0.6
Mouth/teeth dental problems: Dentures	0.7	1.2	4.0	-0.4	0.3	-1.5	0.7	-1.1	-1.2	-0.8	-0.0	-0.8	-1.8	-1.0	-0.9	-2.0
Asthma	1.0	1.9	5.0	1.1	0.4	-1.6	1.3	0.6	-1.9	-1.7	0.5	-1.5	-1.7	-0.4	-2.2	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.5	0.6	0.1	-0.7	1.9	0.1	-1.1	-0.8	0.7	-0.4	-1.0	0.9	-1.0	-0.8
Medication: Cholesterol lowering	2.0	3.1	10.2	-0.7	0.7	3.2	-0.9	-1.4	1.1	0.7	-0.0	2.9	2.1	-0.1	1.8	2.8
Depression (self-reported)	0.5	0.6	1.6	-0.1	-0.9	-1.3	-1.0	-0.3	-0.3	-1.2	-0.4	-1.0	-0.5	-0.5	-0.1	-1.1
Medication: Lansoprazole	0.5	0.6	3.4	-0.5	-1.8	0.0	0.1	0.3	-0.4	0.6	-0.2	0.9	1.1	-0.5	0.8	0.9
Prospective memory result	2.1	2.6	11.1	-1.2	0.0	1.3	0.7	1.5	-2.0	3.3	-0.1	3.1	-0.1	-0.9	-0.6	1.3
Lung cancer (father)	1.4	1.7	3.0	-1.6	-1.1	-1.4	-0.6	-1.5	-1.5	-1.7	-1.7	-0.6	-1.4	1.0	-0.7	-1.2
Illnesses of mother	0.4	0.5	2.1	-0.7	-0.1	1.0	-0.3	-1.5	0.1	-0.6	0.2	0.2	1.0	0.1	1.0	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.8	1.3	1.4	-0.7	0.4	1.5	1.6	0.3	1.7	-1.1	-1.1	-0.1	-1.2	-0.4
Pulse wave Arterial Stiffness index	0.9	1.1	3.9	0.9	0.2	-0.6	0.8	1.3	-0.9	0.4	0.7	0.4	-0.9	-2.0	-1.9	0.3
Impedance of arm (left)	1.1	5.1	17.0	1.9	2.1	-3.1	2.4	0.3	1.3	-2.0	1.1	-4.1	-2.9	0.7	-2.4	-2.1
Arm fat mass (right)	2.1	8.9	22.3	-3.5	-4.3	1.9	-3.8	-1.9	-1.5	0.9	-3.6	4.7	3.1	1.0	3.0	2.0
Trunk predicted mass	1.0	5.6	27.6	-1.5	-1.7	2.2	-3.0	-0.5	-0.6	2.4	-0.8	5.3	3.2	-1.1	2.1	2.0
Standing height	0.2	1.9	8.4	0.1	0.8	0.1	-1.0	0.8	0.3	2.9	0.6	2.5	0.9	-2.3	-0.6	0.7
Length of working week for main job	2.6	2.9	8.2	1.2	0.8	2.6	0.2	2.3	1.0	2.3	0.8	1.7	2.1	-0.6	1.0	2.9
Exposure to tobacco smoke at home	0.8	0.9	4.6	-0.8	-0.8	0.2	0.8	-0.2	-2.1	0.6	-0.6	1.5	-0.4	0.9	-0.4	0.7
Breastfed as a baby	2.2	2.8	15.2	0.4	0.5	2.1	-1.3	2.3	0.2	3.9	1.1	1.3	1.7	-1.1	0.3	1.5
Tense / ‘highly strung’	0.9	1.5	5.6	-0.3	-0.1	-1.7	-0.3	0.2	0.2	-1.5	-0.6	-1.3	-2.2	0.2	-1.3	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	6.9	-0.1	-0.1	-2.5	0.8	-1.8	-1.3	-2.5	-0.2	-1.3	-2.6	-0.2	-1.8	-1.7
Hair/balding pattern: Pattern 4	1.3	3.3	11.4	-2.9	-2.0	-0.4	-1.5	-3.4	0.1	-1.6	-3.0	0.5	-0.0	0.9	1.9	-0.5
Birth weight of first child	0.5	0.9	3.0	1.2	1.7	0.4	1.2	-0.2	1.0	-1.2	1.2	-1.0	0.4	0.1	0.1	0.6
Peak expiratory flow (PEF)	0.3	0.8	5.8	0.3	-0.2	-0.6	0.2	0.1	2.4	-0.5	-0.1	-1.0	-0.7	1.0	0.5	-0.6
Pulse wave reflection index	0.3	0.4	1.4	-0.6	-1.1	0.3	0.1	0.1	-0.1	0.6	-0.8	1.2	0.2	0.6	-0.5	0.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.1	0.8	1.2	-1.0	-0.1	0.3	-0.7	-0.7	0.9	-0.6	-0.7	1.4	-1.0	-0.3
Loud music exposure frequency	0.2	0.2	0.9	0.4	0.4	1.0	-0.3	-0.2	-0.4	0.3	0.5	0.6	0.5	-0.4	0.4	0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.7	1.5	1.4	-0.3	0.8	1.6	1.6	0.5	1.5	-1.5	-0.4	1.4	-0.2	-0.1
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	5.2	-1.5	-2.2	-0.6	-2.1	-0.3	-1.1	-0.0	-1.7	0.6	-0.2	2.3	0.3	0.5
Blood clot in the leg (DVT)	0.3	0.4	1.5	0.9	0.4	0.0	1.1	-0.3	0.4	-0.6	0.6	0.1	0.3	1.2	-0.1	0.1
Medication: Paracetamol	2.6	4.3	13.6	1.3	0.7	-3.2	1.6	-0.3	-0.8	-2.2	0.8	-2.1	-2.8	2.2	-2.0	-3.7
Headache pain in last month	0.7	1.2	5.6	1.0	0.9	-0.5	1.1	-0.6	-0.0	-1.2	1.1	-0.6	-0.9	2.4	-0.8	-1.5
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	4.4	1.0	-0.2	-1.9	1.4	1.0	-0.6	-0.1	0.2	-1.8	-1.7	-2.1	-1.8	-2.0
Glaucoma (self-reported)	0.8	1.0	2.3	1.4	1.0	-0.7	1.1	1.1	0.9	0.5	1.0	-1.0	-0.8	-1.5	-0.9	-0.4
Gout (self-reported)	1.4	2.0	7.4	1.7	1.1	-0.6	2.7	2.0	1.6	1.3	1.9	-0.1	-0.5	0.6	-1.0	-0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	3.1	-0.1	-0.5	1.8	-0.9	0.3	0.9	1.3	0.0	-0.2	1.2	0.2	0.5	0.9
Medication: Amlodipine	1.1	1.5	7.5	-0.7	-1.2	0.5	-0.5	-0.4	1.3	-0.3	-0.6	0.6	1.4	2.7	2.1	1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	3.3	0.2	-0.7	1.1	0.4	0.4	-0.5	-0.3	-0.3	-0.3	0.8	0.0	0.4	1.8
Birth weight	0.1	0.2	0.8	0.9	0.1	-0.4	-0.6	-0.5	0.3	-0.2	0.5	-0.4	-0.0	-0.8	-0.3	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.8	-0.3	-0.9	-0.0	-0.1	0.5	-1.3	-0.3	-0.7	-0.1	0.3	-0.2	0.0	-0.3
High blood pressure (siblings)	0.3	0.4	1.3	0.6	-0.4	-0.4	1.1	1.2	0.3	0.4	0.3	-0.2	0.0	1.0	-0.4	-0.2
Forced vital capacity (FVC), Best measure	0.3	1.0	2.6	0.9	1.3	-0.6	0.7	1.2	0.8	0.1	1.3	-1.0	-1.4	-0.5	-1.6	-0.5
Body fat percentage	1.3	5.1	12.4	-3.2	-3.5	0.7	-3.0	-1.9	-1.1	0.4	-3.3	2.9	1.9	1.2	2.1	0.9
Leg fat percentage (right)	1.5	5.6	15.9	-3.1	-4.0	1.3	-3.0	-1.8	-1.1	0.4	-3.0	2.9	2.4	0.8	2.6	1.1
Arm fat-free mass (right)	1.5	7.7	31.7	-2.7	-2.6	2.4	-3.6	-1.1	-0.8	2.8	-2.0	5.6	3.3	-0.8	2.8	1.9
Exposure to tobacco smoke outside home	0.6	0.8	3.1	-0.9	-1.5	0.9	-0.4	-0.3	-1.8	-1.1	-1.2	0.5	0.4	0.6	0.2	0.4
Comparative body size at age 10	0.5	1.3	3.5	-0.9	-1.9	1.2	-1.6	0.0	-1.3	-0.5	-0.9	0.9	1.0	0.7	1.4	0.9
Number of full brothers	0.8	1.0	5.0	-0.0	-0.8	-0.8	1.5	-1.0	-0.6	0.2	-0.7	0.8	-0.3	-2.2	-1.0	-0.5
Worry too long after embarrassment	1.7	2.9	10.8	-0.2	1.1	-2.1	-0.0	1.8	-1.5	0.5	0.7	-0.4	-3.3	0.6	-3.1	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.7	0.3	-0.7	-1.2	0.3	-0.3	-1.3	-1.1	-0.1	-0.4	-1.0	-1.1	-1.2	-0.2
Wheeze or whistling in the chest in last year	0.6	1.1	3.4	-0.9	-1.3	0.9	0.0	-1.5	-1.9	-0.6	-1.1	1.4	0.8	-0.8	0.8	0.8
Number of children fathered	1.4	1.6	6.4	2.2	1.8	-0.5	0.9	0.4	2.5	0.6	2.0	-0.4	0.9	0.4	-0.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.9	-0.4	-0.0	0.3	1.0	-0.1	-0.1	0.4	-0.4	0.2	-0.8	-0.9	-0.2	0.1
Age at first live birth	1.3	2.4	6.9	2.0	1.4	-2.6	0.2	1.3	0.6	-0.7	2.2	-2.2	-1.4	1.4	-1.1	-0.9
Pulse wave peak to peak time	1.0	1.2	4.2	-1.0	-0.3	0.7	-1.0	-1.4	0.9	-0.3	-0.7	-0.2	1.1	2.0	2.0	-0.1
Health satisfaction	0.9	1.1	4.5	-0.4	0.4	-2.1	0.2	-0.1	-0.8	-0.2	-0.3	-1.1	-1.6	0.8	-1.8	-1.3
Shortness of breath walking on level ground	0.8	0.9	3.5	0.7	0.8	0.5	1.6	1.2	0.7	1.9	0.6	0.4	0.6	-0.2	0.1	1.3
Qualifications: College or University degree	1.6	5.1	16.5	3.1	1.9	-2.9	1.6	0.9	1.9	-2.7	2.1	-4.1	-2.4	-0.0	-1.4	-1.6
Eye problems/disorders: None of the above	0.5	0.5	2.8	-0.8	-0.1	0.4	-0.6	-0.1	-1.4	-0.2	-0.6	0.4	-0.0	1.7	-0.2	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.7	-0.0	0.2	-0.0	-0.4	-0.4	0.4	1.3	0.1	0.7	0.0	0.6	0.3	0.6
Emphysema/chronic bronchitis	1.8	2.0	7.5	-0.5	-1.1	1.5	-1.0	0.6	-1.3	0.8	-0.5	2.7	2.0	-1.7	0.0	2.0
Medication for pain relief, constipation, heartburn	1.1	1.9	6.7	0.0	0.8	1.6	-0.2	1.4	1.2	1.9	0.3	0.4	1.8	-1.8	0.9	2.6
Neck or shoulder pain in last month	0.9	1.3	6.5	0.3	-0.0	0.9	-0.3	1.7	-0.8	1.1	0.6	1.7	0.7	-2.6	-0.1	0.9
Medication: Blood pressure	1.3	2.2	6.1	-1.7	-1.2	1.5	-1.9	-0.7	-0.2	0.3	-1.2	1.6	1.4	2.5	2.0	1.4
Angina (self-reported)	0.4	0.5	1.6	-0.4	-0.2	0.5	-0.4	-0.7	-1.2	0.7	-0.1	1.3	-0.1	-1.2	-0.3	0.4
Migraine (self-reported)	1.8	2.2	8.4	1.2	0.4	-2.0	2.0	0.7	0.4	-1.9	0.3	-2.9	-1.7	0.8	-1.0	-1.3
Medication: Ibuprofen	0.4	0.5	2.5	0.4	0.2	0.1	1.6	-0.2	-1.2	-0.6	0.7	0.6	-0.2	0.9	-0.4	0.0
Medication: Allopurinol	1.3	1.7	6.2	2.2	0.4	-0.2	2.1	1.2	2.5	0.8	1.6	-0.2	0.8	0.9	0.1	0.3
Medication: Omeprazole	2.0	2.4	7.2	0.8	0.5	-2.5	-0.0	-0.1	-1.6	-0.8	0.4	-0.8	-2.7	0.6	-2.7	-2.4
Medication: Seretide 50 evohaler	0.7	0.8	2.5	0.7	1.0	0.2	1.6	0.5	-0.2	0.8	0.7	-0.9	-0.7	1.3	-1.5	0.1
Mean time to correctly identify matches	1.8	3.5	8.9	1.2	1.2	2.8	0.8	1.7	0.5	3.0	1.4	2.3	2.6	-0.5	0.6	2.6
Heart disease (mother)	0.9	1.1	3.6	0.8	1.1	0.8	-1.0	1.7	1.9	1.1	0.8	0.6	0.8	-0.1	0.3	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	7.8	1.2	-0.8	-0.3	0.4	0.8	1.4	-0.8	0.3	-2.8	0.0	0.6	0.3	-1.4
Whole body fat mass	1.7	7.1	18.3	-3.3	-3.8	1.5	-3.6	-1.7	-1.2	1.1	-3.3	4.3	2.8	0.7	2.7	1.6
Leg fat mass (right)	2.1	8.1	20.4	-3.2	-4.0	2.2	-3.6	-1.5	-1.3	1.5	-3.0	4.5	3.5	0.4	3.1	2.0
Arm predicted mass (right)	1.4	7.2	29.6	-2.5	-2.6	2.1	-3.6	-1.0	-0.9	2.7	-2.0	5.4	3.1	-0.9	2.5	1.8
Pulse rate, automated reading	0.2	0.8	2.1	0.3	-0.4	-0.6	0.8	0.3	-1.5	-1.2	0.5	-1.1	-0.8	-1.4	0.3	-1.1
Alcohol intake frequency.	0.8	1.9	4.9	-1.1	-0.8	1.4	-0.7	-1.4	-0.0	0.6	-0.8	2.1	2.2	0.9	2.0	1.5
Comparative height size at age 10	0.3	1.6	6.7	0.0	0.2	1.2	-1.3	0.2	0.7	2.0	-0.2	2.6	1.8	-0.6	0.8	1.3
Number of full sisters	1.4	1.7	4.8	-1.4	-2.0	0.0	-0.7	-1.2	-2.2	0.4	-1.9	1.2	-1.0	-1.6	-0.6	-0.3
Suffer from ‘nerves’	1.6	2.5	7.2	-0.8	-0.8	-1.4	-0.5	-1.3	-2.4	-1.6	-1.1	0.8	-2.7	-0.5	-2.1	-2.2
Overall health rating	0.4	0.9	5.6	-0.7	-0.5	0.4	-0.6	-0.9	-0.2	-0.2	-0.5	1.2	0.6	2.4	1.0	0.7
Chest pain or discomfort	0.3	0.5	1.4	0.9	0.9	-0.7	0.8	0.1	0.1	-0.4	0.9	0.2	-0.5	1.2	-0.5	-0.7
Had major operations	1.0	1.2	3.9	0.3	0.2	1.6	-0.8	-0.1	1.1	0.1	0.5	1.8	1.5	0.5	2.0	1.0
Age at last live birth	0.9	1.4	3.8	1.7	1.2	-1.9	-0.4	1.1	0.1	-0.3	1.5	-0.9	-1.6	0.0	-1.3	-1.1
Family relationship satisfaction	1.0	1.2	3.6	0.7	1.3	0.9	0.5	1.5	0.3	1.9	1.7	0.3	0.8	-1.2	-0.0	1.2
Leg pain on walking	0.4	0.5	1.9	-0.8	0.2	-0.0	-0.4	1.0	-0.4	1.4	-0.8	0.1	0.0	1.1	0.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	3.5	-0.0	-0.5	-0.1	-0.0	-0.2	-0.0	-1.9	-0.3	-1.0	0.5	-0.0	0.7	0.0
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.0	-1.3	-1.5	-0.7	-1.2	-1.7	-0.0	-0.6	-0.9	0.2	0.7	1.0	1.7	0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.5	0.3	1.1	-1.1	-0.2	0.5	0.5	0.6	0.4	-0.4	-0.9	-1.2	-0.6	-0.5
Medication: Aspirin	0.8	1.1	2.7	-0.8	-1.0	1.5	-1.6	-0.2	0.8	0.3	-0.7	1.4	1.2	-0.5	1.6	0.5
Supplements: Vitamin C	1.1	1.3	2.7	0.9	1.2	-1.5	1.6	0.3	0.3	-1.1	0.2	-1.6	-1.4	1.2	-1.0	-0.8
Knee pain experienced in last month	0.8	1.3	3.2	1.8	1.5	-0.5	1.3	1.8	-0.8	0.2	1.4	-0.3	0.2	-0.7	-1.6	-0.1
Hypertension (Self-reported)	0.8	2.3	9.1	-1.9	-2.4	0.5	-1.3	-0.7	-1.7	0.4	-1.3	1.9	0.3	3.0	1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.7	0.4	0.1	0.6	0.1	0.7	0.5	1.3	0.5	0.2	0.2	1.0	-0.6	0.4
Illnesses of father: Heart disease	0.8	1.1	5.0	-0.4	-1.3	2.2	-0.5	-0.1	-1.3	0.5	-0.9	1.1	0.2	-1.7	-0.4	0.7
Illnesses of siblings: Diabetes	0.3	0.3	1.4	-0.6	-0.9	-0.8	1.2	0.1	-0.1	0.1	-0.6	-0.6	-0.4	0.3	0.4	-0.4
Smoking status: Previous	0.4	0.5	3.1	-0.6	-0.9	-0.4	0.2	0.6	0.1	1.8	-0.6	0.2	0.4	-0.9	0.6	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.7	1.2	1.5	0.1	0.4	0.6	-1.1	1.6	1.6	1.3	-0.6	-0.3	-1.0	-0.3
Whole body fat-free mass	1.2	6.6	30.7	-2.0	-2.2	2.3	-3.2	-0.6	-0.7	2.6	-1.5	5.5	3.2	-0.9	2.3	2.0
Leg fat-free mass (right)	1.1	5.9	27.8	-1.8	-2.1	2.2	-2.7	-0.6	-0.6	2.5	-1.6	5.3	3.1	-0.8	2.1	2.1
Arm fat percentage (left)	1.6	6.3	16.3	-3.0	-4.0	1.2	-3.0	-1.9	-1.3	-0.0	-3.4	3.5	2.4	1.7	2.6	1.4
Average weekly red wine intake	0.2	0.2	1.0	-0.1	-0.0	-0.2	0.2	1.0	0.2	0.8	0.7	-0.6	-0.6	-0.1	-0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.5	0.2	-0.3	-0.3	-0.4	0.4	0.5	0.3	0.0	-0.1	-0.2	-0.7	-0.3	-0.2
Mood swings	3.6	6.5	14.4	-2.4	-1.6	-3.7	0.1	-2.5	-3.6	-2.8	-1.8	-1.1	-3.8	0.5	-2.0	-3.5
Loneliness, isolation	0.4	0.5	1.4	-0.7	-0.3	-0.2	-0.6	-1.2	-0.8	-1.1	-0.7	-0.4	-0.8	0.3	-0.2	-0.8
Long-standing illness, disability or infirmity	0.7	1.1	3.3	1.2	1.0	-0.4	1.1	-0.1	0.4	-1.8	1.3	-1.6	0.0	1.2	-1.0	-0.4
Ever had bowel cancer screening	0.8	0.9	4.9	-0.7	1.2	1.0	-1.0	-1.0	-0.3	1.0	0.4	2.2	-0.1	0.2	-0.1	0.7
Diabetes diagnosed by doctor	0.5	0.7	2.0	0.2	-0.4	0.9	-0.4	-0.7	1.2	0.5	0.1	1.2	1.4	0.6	1.3	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	5.1	1.0	-0.9	-1.0	0.9	0.3	-2.2	-1.5	0.7	-1.0	-1.4	-1.1	-1.6	-1.7
Friendships satisfaction	1.4	1.7	5.6	1.5	1.8	0.6	1.3	1.3	0.4	2.4	2.1	0.3	-0.2	-0.5	-1.3	0.5
Qualifications: nursing, teaching	1.5	2.4	4.1	2.0	1.7	-1.7	1.4	2.0	0.9	-0.1	1.7	-2.0	-1.8	0.4	-1.8	-0.8
Commuting to job workplace: Walk	0.6	0.7	3.9	0.1	-0.3	-0.3	1.1	-0.1	-0.1	-2.0	-0.4	-0.7	-1.1	0.1	-0.4	-1.2
Eye problems/disorders: Cataract	0.9	1.0	4.6	0.9	-0.8	-0.7	1.2	-0.1	1.4	-1.3	-0.1	-2.1	-0.3	0.2	0.2	-1.2
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	11.7	2.2	0.7	-1.4	1.5	1.7	-2.3	0.2	1.8	-0.7	-1.7	-1.9	-3.4	-0.9
Medication for cholesterol	0.3	0.5	1.6	0.4	1.0	0.5	-0.3	0.5	1.2	-1.3	0.3	-1.1	0.3	-0.4	0.6	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	2.1	0.5	0.3	-0.5	0.5	0.9	-1.0	0.4	0.4	0.2	-0.5	-0.3	-1.4	-0.5
Back pain experienced in last month	0.8	1.2	7.3	-1.5	-1.3	-0.4	0.8	0.1	-2.7	0.1	-0.7	0.7	-0.5	1.4	-0.6	-0.3
Mineral and other dietary supplements	0.5	0.6	2.4	1.5	0.6	-0.0	0.6	0.6	-0.1	0.5	1.0	-1.0	-0.4	-1.0	-1.1	-0.4
Breast cancer (self-reported)	0.7	0.8	2.0	-0.3	0.8	-1.4	0.5	-0.6	0.0	-1.4	-0.1	-0.7	-1.3	0.8	-0.6	-1.4
Asthma (self-reported)	0.7	1.4	3.9	0.9	0.6	-1.2	1.3	0.8	-1.7	-1.3	0.4	-1.3	-1.5	-0.3	-2.0	-1.0
Osteoporosis (self-reported)	0.7	0.9	3.6	0.9	0.1	-1.9	0.8	0.5	-0.3	-0.9	0.6	-1.2	-0.8	-1.0	-1.1	-0.4
Osteoarthritis (self-reported)	0.2	0.3	1.2	-0.4	0.1	-0.5	0.8	-0.5	-1.1	0.0	-0.5	0.6	-0.4	0.1	-0.3	-0.3
Medication: Aspirin	0.7	0.9	2.1	-0.9	-1.2	1.2	-1.4	0.0	0.5	0.3	-0.8	1.4	1.0	-0.1	1.4	0.4
Medication: Gliclazide	0.1	0.1	0.3	0.5	0.1	0.6	0.4	0.0	0.2	-0.3	-0.0	0.3	0.4	-0.4	-0.0	0.4
Illnesses of father: None of the above (group 1)	3.8	4.6	11.2	2.8	3.3	-3.1	1.8	1.2	1.6	-0.5	2.9	-2.2	-1.7	0.7	-1.9	-2.1
Smoking status: Current	0.5	0.8	1.9	1.3	1.3	1.4	1.1	0.4	0.3	-0.4	1.0	-0.2	0.6	-0.7	-0.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	7.6	2.2	2.0	-1.0	0.3	2.1	1.6	0.3	2.8	-1.1	-0.7	-0.2	-1.1	-0.4
Whole body water mass	1.2	6.7	30.4	-2.1	-2.4	2.3	-3.3	-0.8	-0.8	2.4	-1.7	5.5	3.2	-0.9	2.4	1.9
Leg predicted mass (right)	1.1	5.8	26.9	-1.8	-2.0	2.2	-2.7	-0.6	-0.5	2.4	-1.6	5.2	3.1	-0.8	2.1	2.1
Arm fat mass (left)	2.1	8.6	21.8	-3.4	-4.2	1.8	-3.8	-2.0	-1.4	0.8	-3.5	4.7	3.0	1.0	3.1	1.9
Number of self-reported non-cancer illnesses	0.3	0.5	3.3	0.7	0.2	-0.2	0.1	0.4	0.3	0.0	1.1	-0.1	0.6	1.8	-0.1	0.8
Average weekly champagne plus white wine intake	0.9	1.2	3.6	-1.4	-1.0	-1.3	-0.8	-1.9	-0.4	-0.5	-1.2	0.5	-0.9	0.8	0.7	-1.6
Miserableness	3.0	5.2	14.8	-1.3	-0.9	-2.9	0.8	-1.9	-2.5	-2.2	-0.8	-1.9	-3.7	1.8	-2.3	-3.9
Guilty feelings	1.3	2.0	7.2	-0.8	-0.2	-1.8	0.1	0.7	-1.3	-0.7	-0.2	-0.8	-2.7	2.6	-1.5	-1.7
Wears glasses or contact lenses	0.8	0.9	2.3	1.2	0.7	-0.1	0.6	0.8	1.1	0.5	1.1	0.7	1.2	0.2	1.2	1.5
Ever taken oral contraceptive pill	0.5	0.5	2.7	0.7	-0.3	0.6	-1.6	-0.9	0.8	-0.3	0.1	0.9	0.5	0.3	0.6	0.4
Hearing aid user	1.4	1.6	10.1	-1.2	-0.5	0.3	-0.5	-0.2	-2.0	-0.1	-0.6	1.4	-0.8	-3.2	-0.9	-0.9
Mother’s age at death	2.1	2.6	10.6	2.3	1.6	-0.8	1.4	1.1	0.7	-1.2	2.3	-3.2	-0.8	-1.9	-0.6	-0.3
Financial situation satisfaction	0.7	0.9	7.9	-0.4	-0.8	-0.5	-0.1	-0.4	-2.8	-0.4	-0.2	-0.6	-0.9	0.4	-1.1	-0.1
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.7	-0.2	0.0	-2.4	-0.3	0.3	-2.2	-0.9	0.0	-1.2	-2.6	0.4	-1.9	-2.1
Commuting to job workplace: Public transport	1.1	1.3	3.2	1.6	1.7	0.5	0.2	1.8	-0.7	1.2	1.8	-0.4	-0.5	-0.5	-1.5	-0.6
Eye problems/disorders: Glaucoma	1.4	1.7	3.4	1.7	1.5	-0.9	1.7	1.1	1.8	1.1	1.7	-0.7	-0.2	-1.8	-0.6	-0.3
Medication: Blood pressure	0.5	1.0	2.4	-0.6	-1.2	-1.1	0.1	0.1	-1.5	1.1	-0.3	0.8	-1.1	1.2	-1.3	-1.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.8	0.4	-1.3	0.5	-0.2	-0.2	-0.5	-0.3	-0.5	-0.0	0.9	-0.8	0.7	-0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.6	-1.1	-0.9	0.2	-0.6	-0.9	0.3	-1.5	-0.6	0.5	0.3	1.6	1.3	0.1
High cholesterol (Self-reported)	0.4	0.7	2.9	-1.1	-0.0	0.6	-0.4	-1.1	-0.7	-0.2	-0.7	1.1	0.0	-1.7	0.1	0.9
Medication: Bendroflumethiazide	1.0	1.5	3.1	-1.0	-1.7	-1.3	-0.6	-1.8	-1.4	-1.7	-0.7	-0.7	-1.0	1.7	-0.1	-0.9
Medication: Paracetamol	1.1	1.7	5.6	0.8	0.5	-2.3	1.0	0.2	-0.4	-0.9	0.6	-0.9	-1.7	1.6	-1.4	-2.4
Medication: Lisinopril	0.3	0.3	1.6	-0.3	-0.4	0.3	-0.9	1.3	-0.2	0.9	-0.1	0.1	-0.3	0.1	-0.4	-0.7
Medication: Atorvastatin	0.7	0.8	4.1	0.1	0.4	-0.1	0.3	-1.2	1.0	-2.0	-0.6	-1.5	-0.7	0.2	-0.1	-0.9
Illnesses of father: High blood pressure	1.7	2.1	7.4	-1.7	-2.7	-0.4	-1.1	-1.0	-1.7	-2.2	-2.2	0.5	-0.6	1.4	0.4	-0.0
Alcohol drinker status: Never	0.5	0.6	1.9	0.4	0.5	0.8	0.5	0.1	1.4	0.7	1.1	-0.6	0.4	1.4	0.5	0.5
Ever smoked	0.1	0.1	0.4	-0.6	-0.3	0.1	0.2	-0.5	-0.3	0.0	-0.4	-0.2	-0.0	-0.2	0.1	-0.5
Basal metabolic rate	1.4	7.5	32.2	-2.4	-2.8	2.3	-3.6	-0.9	-1.0	2.4	-2.0	5.7	3.3	-0.7	2.5	2.0
Leg fat percentage (left)	1.4	4.9	12.0	-3.0	-3.5	1.3	-2.8	-1.9	-1.0	0.6	-2.8	2.7	2.2	0.8	2.4	1.3
Arm fat-free mass (left)	1.6	7.9	30.7	-2.9	-3.0	2.4	-3.8	-1.4	-1.2	2.2	-2.4	5.5	3.2	-0.6	2.6	2.0
Number of operations (self-reported)	0.7	1.0	2.6	-1.0	-0.6	0.3	-1.2	-1.2	-0.4	-1.3	-1.1	1.4	0.7	0.7	1.6	0.3
Average weekly beer plus cider intake	0.5	0.7	2.4	0.6	-0.5	-1.1	0.8	-0.5	0.2	0.3	-0.8	-0.4	-1.2	-0.3	-0.9	-1.6
Irritability	2.3	3.9	10.1	-0.9	-1.4	-2.8	-1.1	-1.0	-1.6	-2.7	-1.5	-1.5	-3.2	0.8	-2.3	-2.9
Risk taking	1.1	1.6	5.5	1.5	0.5	-2.3	1.6	0.8	-0.5	-1.2	1.0	-2.3	-0.7	-0.6	-1.0	-0.5
Ever had prostate specific antigen (PSA) test	0.5	0.5	3.0	0.2	0.4	-0.9	-0.2	-0.2	1.7	-0.7	0.4	-1.1	0.2	0.9	0.6	0.3
Fractured/broken bones in last 5 years	2.6	3.3	7.8	2.3	1.9	-1.5	0.9	0.5	0.5	-1.9	2.3	-2.8	-1.9	-2.0	-1.5	-2.0
Age started oral contraceptive pill	0.3	0.4	1.4	0.5	0.5	-0.7	-0.0	-0.1	0.8	0.5	0.9	-1.0	-0.6	-1.2	-0.1	-0.3
Diastolic blood pressure, automated reading	1.5	4.7	14.9	-2.3	-3.9	-2.3	-2.0	-1.9	-2.8	-2.2	-2.6	0.2	-1.1	2.0	0.7	-1.8
Ever depressed for a whole week	1.2	1.5	3.7	0.3	0.7	-1.6	0.0	-0.4	-1.8	-1.9	0.7	-1.2	-1.6	-1.4	-1.7	-0.2
Unable to work because of sickness or disability	1.3	1.7	5.2	-1.4	-1.4	-0.3	-1.4	-2.3	-0.8	-2.2	-1.6	-0.7	-0.8	-0.3	0.9	-0.9
Commuting to job workplace: Cycle	3.2	3.8	17.6	2.8	4.2	0.5	3.0	0.7	1.8	-0.1	2.7	-1.0	-0.3	0.1	-1.5	0.7
Myopia	1.6	2.4	6.1	-1.5	-2.5	0.4	-2.0	-1.5	-1.6	-0.3	-1.9	1.7	1.6	1.0	1.3	1.1
Vascular/heart problems diagnosed by doctor	0.9	2.4	7.5	1.8	2.3	-0.9	1.9	0.5	1.7	-0.9	1.1	-2.0	-0.6	-2.7	-0.9	-0.3
Cholesterol lowering medication	0.7	1.0	3.1	-1.8	-1.6	0.5	-0.5	-1.7	-1.0	-0.1	-1.4	0.8	0.2	-0.2	0.8	-0.1
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	9.3	1.1	1.1	-2.6	0.2	0.2	-0.9	-1.0	0.7	-1.3	-3.1	0.2	-2.8	-2.6
Pain experienced in last month	0.3	0.4	1.5	-0.1	0.4	0.1	-1.2	-1.1	0.9	-0.5	-0.1	-0.9	-0.1	0.1	0.9	0.3
Supplements: Calcium	0.2	0.2	0.8	-0.1	0.4	-0.7	0.1	0.3	-0.4	0.3	0.4	-0.1	-0.9	0.8	-0.1	-0.7
Basal cell carcinoma (self-reported)	1.8	2.2	8.4	1.1	2.9	-0.8	1.5	0.4	2.0	-1.1	1.0	-2.4	-1.1	0.7	-0.5	-1.2
Heart attack/myocardial infarction (self-reported)	0.8	1.1	3.7	-1.0	-0.9	1.5	-1.6	-1.0	-1.0	0.7	-0.3	1.9	0.9	-0.0	0.3	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.7	0.5	0.2	-0.3	1.0	-0.5	0.1	-0.9	0.3	-0.1	-0.1	1.3	-0.3	-0.2
Heart disease (siblings)	0.3	0.4	1.1	1.1	-0.7	-0.9	0.9	0.2	-0.0	-0.2	0.9	-0.4	-0.3	-0.0	-0.7	-0.6
Alcohol drinker status: Previous	0.7	0.8	4.3	-0.7	-0.3	0.5	-0.1	0.0	1.2	1.1	-0.4	0.1	0.6	2.1	1.3	0.8
Pack years of smoking	0.2	0.3	1.2	-0.4	-0.3	0.2	-0.5	0.5	-0.9	-0.3	-0.0	0.5	0.3	-1.1	0.3	0.8
Impedance of whole body	1.2	5.9	21.6	1.6	2.2	-3.2	2.2	0.3	0.9	-1.8	1.2	-4.6	-3.4	0.5	-3.0	-2.5
Leg fat mass (left)	2.0	7.7	18.9	-3.2	-3.8	2.2	-3.5	-1.6	-1.2	1.4	-3.0	4.3	3.3	0.6	3.0	2.0
Arm predicted mass (left)	1.4	7.1	27.3	-2.7	-2.9	2.2	-3.7	-1.3	-1.1	2.0	-2.3	5.2	3.0	-0.5	2.6	1.8