TWAS hub - SETDB2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1750	0.0380	0.0e+00	0.215	0.155	0.199	0.189	0.210	1.1e-25	2.0e-18	1.2e-23	1.6e-22	4.0e-25
2	GTEx	Breast Mammary Tissue	0.1600	0.0730	9.7e-03	0.004	NA	0.000	NA	0.004	1.9e-01	NA	3.2e-01	NA	1.9e-01
3	GTEx	Cells Transformed fibroblasts	0.2080	0.0530	3.7e-10	0.138	NA	0.178	NA	0.157	1.6e-10	NA	2.6e-13	NA	7.1e-12
4	GTEx	Colon Sigmoid	0.2770	0.1130	3.9e-03	0.003	NA	0.066	NA	-0.006	2.5e-01	NA	2.5e-03	NA	6.1e-01
5	GTEx	Colon Transverse	0.1540	0.0620	7.3e-04	0.020	NA	0.029	NA	0.046	3.7e-02	NA	1.6e-02	NA	3.0e-03
6	GTEx	Nerve Tibial	0.1844	0.0508	9.1e-07	0.098	NA	0.082	NA	0.096	1.9e-07	NA	2.0e-06	NA	2.8e-07
7	GTEx	Pancreas	0.1050	0.0490	5.2e-03	0.130	NA	0.072	NA	0.088	4.1e-06	NA	5.6e-04	NA	1.4e-04
8	GTEx	Pituitary	0.2570	0.0950	4.2e-03	0.127	NA	0.204	NA	0.202	4.5e-04	NA	7.4e-06	NA	8.5e-06
9	GTEx	Stomach	0.3370	0.0910	1.6e-05	0.037	NA	0.070	NA	0.045	7.3e-03	NA	2.9e-04	NA	3.1e-03
10	METSIM	Adipose	0.0583	0.0210	9.3e-06	0.034	0.046	0.050	NA	0.046	5.6e-06	1.5e-07	5.1e-08	NA	1.6e-07
11	YFS	Blood	0.1176	0.0231	0.0e+00	0.129	0.137	0.148	0.147	0.146	7.6e-40	1.4e-42	5.3e-46	1.2e-45	1.7e-45
12	TCGA	Breast Invasive Carcinoma	0.0339	0.0163	1.5e-03	-0.001	0.013	0.010	NA	0.002	6.1e-01	9.4e-04	2.8e-03	NA	9.0e-02
13	TCGA	Glioblastoma Multiforme	0.1610	0.0800	1.1e-03	0.128	0.097	0.084	NA	0.101	1.0e-04	7.0e-04	1.5e-03	NA	5.4e-04
14	TCGA	Kidney Renal Clear Cell Carcinoma	0.0463	0.0246	2.1e-03	0.007	0.026	0.014	NA	0.013	5.3e-02	5.1e-04	8.3e-03	NA	1.0e-02
15	TCGA	Brain Lower Grade Glioma	0.0638	0.0266	2.8e-05	0.013	0.047	0.048	NA	0.044	1.0e-02	4.5e-06	3.5e-06	NA	9.2e-06
16	TCGA	Pheochromocytoma and Paraganglioma	0.1050	0.0610	1.8e-03	0.054	0.040	0.040	NA	0.046	3.5e-03	1.1e-02	1.1e-02	NA	6.6e-03
17	TCGA	Prostate Adenocarcinoma	0.0894	0.0404	5.3e-03	0.034	0.019	0.020	NA	0.025	1.6e-04	3.8e-03	3.1e-03	NA	1.2e-03
18	TCGA	Thyroid Carcinoma	0.0520	0.0220	6.1e-07	0.068	0.074	0.088	NA	0.085	3.2e-07	1.1e-07	7.1e-09	NA	1.2e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Migraine (self-reported)	4.2	5.3	9.4	-2.9	-0.9	-2.8	0.3	-1.8	-2.5	-3.1	-1.2	-2.5	-2.2	-2.9	-1.8	-2.6	-1.5	-2.7	-2.9	-1.5	-2.8
Coronary Artery Disease (CAD)	3.8	4.5	7.3	2.4	1.9	2.7	-0.1	1.4	2.3	2.4	2.2	2.5	1.7	2.7	1.6	2.5	1.9	2.1	2.7	0.3	2.5
Smoking status: Current	3.8	6.0	11.1	-2.8	-1.8	-3.0	-1.8	-2.3	-3.0	-2.8	-2.5	-2.7	-1.5	-2.8	-1.7	-3.3	-2.5	-1.5	-2.7	-0.4	-2.8
Type 2 Diabetes (T2D) (2012)	3.4	4.0	8.6	-2.3	-0.5	-2.3	0.7	-0.7	-2.7	-2.3	-1.0	-2.9	-0.6	-2.2	-1.8	-2.9	-1.7	-2.7	-2.3	-0.6	-2.0
Ever unenthusiastic/disinterested for a whole week	3.2	3.9	9.1	-1.9	-0.7	-2.2	-1.4	-1.1	-2.4	-1.7	-2.6	-2.6	0.2	-1.6	-3.0	-2.9	-2.8	-1.5	-1.7	-1.5	-1.2
Had other major operations	3.1	3.8	8.4	-2.7	-0.4	-1.9	-2.8	-1.1	-2.0	-2.7	-1.0	-1.2	0.2	-2.1	-1.4	-1.7	-2.9	-2.4	-2.7	-0.2	-2.2
Major Depression (MDD)	2.9	3.6	6.9	-2.5	-1.0	-2.3	-0.9	-1.4	-2.1	-2.4	-2.0	-1.0	-0.3	-1.9	-1.7	-1.9	-2.3	-2.6	-2.6	-0.2	-2.2
Current tobacco smoking	2.9	4.7	9.5	-2.4	-1.4	-2.6	-2.3	-2.1	-2.7	-2.4	-2.3	-2.1	-1.3	-2.5	-1.3	-3.1	-2.1	-1.2	-2.3	-0.2	-2.5
Lung FVC	2.5	12.7	29.9	-3.9	-3.3	-4.3	1.4	-5.1	-4.6	-3.8	-5.5	-3.1	-5.3	-4.0	-0.3	-3.9	-1.1	-0.7	-2.2	-1.7	-3.4
Medication: Ramipril	2.5	3.2	5.5	-2.3	-1.0	-2.3	-1.4	-2.1	-2.2	-2.3	-1.9	-1.1	-1.3	-2.2	-0.3	-1.6	-2.2	-1.4	-1.9	0.8	-2.1
Birth weight of first child	2.4	4.3	10.5	-2.7	-0.4	-2.7	-1.5	-1.9	-2.1	-2.7	-3.2	-2.6	-2.3	-2.2	-0.6	-2.4	-1.1	-1.0	-1.9	-0.7	-2.3
Intelligence (Savage-Jansen 2018)	2.3	7.2	15.8	-3.0	-1.5	-3.3	1.7	-2.8	-2.7	-3.2	-4.0	-2.9	-3.0	-2.4	-2.5	-3.6	-0.7	-2.4	-2.4	-1.5	-2.8
Allergy	2.3	5.3	10.9	-3.0	-1.4	-2.8	-0.3	-1.4	-2.6	-3.1	-1.2	-2.2	-1.4	-3.3	-2.0	-2.4	-2.3	-2.1	-2.9	0.5	-3.2
Medication: Gliclazide	2.3	2.6	6.6	1.6	1.4	2.0	-0.7	1.3	2.2	1.7	1.4	1.9	1.8	1.8	0.8	2.6	1.3	0.8	2.0	1.0	1.7
Alzheimer’s Disease (in mother)	2.2	2.5	8.5	1.1	0.8	2.3	0.7	1.7	1.6	1.4	0.7	2.0	0.6	2.4	-0.6	1.1	0.3	0.8	1.8	-2.3	2.9
Fluid intelligence score	2.2	4.6	14.8	-2.0	-0.7	-2.6	0.8	-2.5	-2.7	-2.2	-3.9	-1.7	-2.8	-1.8	-1.0	-3.3	-0.4	-1.5	-1.7	-1.2	-2.3
Worry too long after embarrassment	2.1	3.6	7.4	-2.3	-1.2	-2.0	-1.3	-0.7	-1.8	-2.3	-1.5	-2.7	0.0	-1.7	-2.2	-2.5	-2.6	-1.9	-2.6	-0.1	-1.7
Smoking status: Previous	2.1	3.2	10.4	1.3	-0.3	1.9	-0.1	0.7	1.9	1.6	0.3	3.2	1.8	2.4	-0.3	2.1	-0.7	1.6	2.8	-1.8	2.7
Deep venous thrombosis (DVT) (self-reported)	2.1	2.8	8.9	1.6	1.0	2.2	-0.1	0.9	1.8	1.7	1.3	3.0	0.6	1.9	1.7	2.3	1.2	1.2	1.8	-1.0	2.1
Verbal and Numeric Reasoning (VNR)	2.0	4.9	16.9	-2.2	-1.4	-2.8	1.9	-2.3	-2.4	-2.3	-4.1	-1.5	-2.7	-1.7	-2.1	-3.0	-0.9	-1.4	-1.3	-1.9	-1.8
Hayfever, allergic rhinitis or eczema	2.0	4.4	9.8	2.6	0.6	2.7	0.3	1.2	2.4	2.8	0.5	1.7	1.1	3.1	1.5	2.1	2.0	2.4	3.0	-0.4	3.1
Medication: Bendroflumethiazide	2.0	3.0	8.3	-2.0	-1.6	-2.0	0.5	-1.7	-1.8	-2.1	-1.2	-2.9	-1.6	-2.1	-0.9	-1.4	-1.6	-1.1	-2.3	-0.5	-2.1
Mean Putamen Volume	1.9	2.2	5.5	-1.5	-0.2	-2.0	0.4	-1.6	-1.8	-1.8	-0.8	-1.5	-1.6	-1.7	0.2	-1.8	-0.2	-1.5	-2.0	0.9	-2.3
Medication: Amlodipine	1.9	2.7	7.3	-1.3	-1.1	-1.5	0.7	-2.0	-1.7	-1.5	-0.8	-0.7	-2.6	-2.7	2.1	0.1	-0.3	-0.8	-1.9	1.9	-2.6
Emphysema/chronic bronchitis	1.9	2.1	8.5	1.4	0.7	1.6	-1.1	1.1	1.8	1.4	1.5	2.1	2.9	1.9	0.6	1.2	0.4	-0.2	1.1	-0.4	1.6
Pain type(s) experienced in last month: Hip pain	1.9	2.3	6.2	1.4	0.9	1.7	-0.7	0.4	2.2	1.4	1.9	2.3	1.1	1.4	1.7	2.5	1.1	1.1	1.3	1.4	1.3
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	6.2	1.4	2.3	1.5	-1.1	0.9	1.6	1.2	2.5	1.0	1.9	1.2	2.1	2.1	0.9	0.1	0.4	2.0	0.8
Medication for hormone replacement therapy	1.8	2.0	4.2	2.0	0.7	1.2	0.7	2.0	1.2	1.9	2.0	1.0	1.3	1.7	0.6	0.6	1.6	0.9	2.0	0.7	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	6.8	-1.7	-0.6	-1.9	-0.4	-1.5	-1.9	-1.8	-0.8	-2.6	-1.2	-2.2	-0.4	-1.7	-1.0	-1.2	-2.5	0.9	-2.4
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	6.9	-1.4	-1.6	-1.9	0.7	-1.2	-2.3	-1.5	-2.4	-2.3	-1.8	-1.6	-1.6	-2.6	-0.9	-0.9	-1.7	-0.3	-2.0
Ever depressed for a whole week	1.8	2.2	4.5	-1.4	-0.6	-1.5	-1.8	-1.2	-1.6	-1.3	-1.9	-1.8	0.3	-1.5	-1.8	-1.9	-2.1	-1.6	-1.3	-1.0	-1.1
Cardiovascular Disease	1.7	5.6	11.5	-2.9	-0.0	-2.6	-2.0	-1.6	-2.9	-3.0	-1.3	-2.5	-0.5	-2.8	-0.6	-2.6	-2.9	-2.9	-3.4	1.4	-3.1
Hand grip strength (left)	1.7	4.6	10.5	2.5	3.1	2.3	0.3	2.2	2.1	2.4	0.8	3.2	1.8	3.2	1.7	1.2	1.8	1.3	2.2	0.1	2.7
Worrier / anxious feelings	1.7	3.3	9.6	-2.2	-0.6	-1.7	-0.6	0.3	-1.8	-2.1	-0.7	-3.1	0.3	-1.6	-2.9	-2.3	-2.2	-1.9	-2.1	-1.4	-1.3
Average weekly spirits intake	1.6	1.9	7.0	-1.2	2.2	-0.5	-2.6	0.1	-0.8	-1.0	-0.7	-0.2	2.2	0.5	-1.6	-0.8	-2.2	-1.5	-0.8	-1.6	0.6
Noisy workplace	1.6	1.9	7.1	1.1	0.8	1.1	1.4	-0.2	1.6	1.1	1.4	1.9	-0.5	0.6	2.2	2.7	1.2	1.5	1.5	0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	12.4	-1.3	-1.7	-1.8	1.3	-3.3	-2.1	-1.4	-2.9	-2.1	-3.5	-1.6	1.2	-1.4	0.1	0.5	-0.9	0.0	-1.6
Medication: Blood pressure	1.6	3.1	6.0	-1.6	-1.3	-2.0	-1.4	-1.0	-2.2	-1.7	-1.1	-2.3	-1.1	-2.4	-0.2	-2.1	-2.0	-1.3	-2.3	1.5	-2.4
Primary Biliary Cirrhosis	1.5	2.1	5.9	1.6	0.4	1.8	-0.4	2.1	1.4	1.6	2.4	0.8	1.6	1.3	1.3	1.8	1.1	1.4	1.0	-0.0	1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	13.1	1.6	2.2	2.0	-1.3	2.5	1.1	1.8	2.5	0.5	3.6	2.4	0.1	0.4	1.0	1.5	1.4	-0.4	2.2
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.5	2.1	-0.8	1.4	-0.5	0.6	1.3	2.0	0.6	1.4	0.7	1.0	1.2	1.6	1.6	1.4	2.1	1.0	0.9
Shortness of breath walking on level ground	1.5	1.7	3.6	1.4	0.6	1.4	-0.1	0.7	1.6	1.5	1.3	1.3	1.5	1.5	1.0	1.7	0.6	1.6	1.9	1.0	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	7.0	1.0	-1.1	0.2	0.6	-0.4	-0.6	0.9	0.7	0.4	-1.9	-0.7	2.6	0.2	2.6	2.0	0.7	2.2	-0.6
Eye problems/disorders: Glaucoma	1.5	1.8	5.4	-1.4	-2.0	-1.0	0.5	-2.0	-0.9	-1.2	-2.3	-0.6	-1.6	-0.8	-1.7	-0.0	-1.6	0.1	-0.9	-2.0	-0.4
Diastolic blood pressure, automated reading	1.5	4.8	10.0	-1.3	0.1	-2.5	-0.0	-3.2	-2.8	-1.7	-2.3	-3.1	-2.0	-2.5	1.7	-2.1	-0.5	-0.3	-2.4	3.1	-3.0
Schizophrenia vs Biploar Disorder	1.4	1.8	5.4	-1.3	-1.4	-1.3	1.0	-2.1	-1.2	-1.2	-2.1	0.9	-1.4	-1.1	-0.8	-1.1	-1.5	0.3	0.1	-2.3	-0.7
Crohns Disease (2017)	1.4	3.1	6.7	2.0	1.5	2.2	-0.2	2.6	2.0	2.1	2.6	1.5	1.8	2.2	0.3	1.9	0.6	1.2	1.5	0.1	2.2
Neuroticism	1.4	3.3	9.1	-2.6	-0.3	-2.1	-0.3	-0.1	-1.3	-2.6	0.0	-2.6	0.2	-1.9	-1.6	-1.3	-1.7	-2.9	-3.0	1.0	-2.1
Nervous feelings	1.4	2.5	6.7	-2.2	0.7	-1.3	-1.9	0.0	-1.0	-2.1	-0.2	-2.0	0.9	-0.8	-2.6	-1.6	-1.8	-2.1	-2.4	-0.8	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	9.5	1.7	1.4	2.3	-1.4	2.1	1.4	1.9	2.0	0.8	3.1	2.5	0.2	0.8	1.1	1.9	1.6	-1.2	2.5
Qualifications: None of the above	1.4	3.0	9.8	1.2	0.8	2.2	-0.4	2.0	2.7	1.3	3.1	1.8	2.4	1.7	0.3	3.1	0.0	-0.1	0.5	0.2	1.7
Neuroticism score	1.4	3.0	9.3	-2.4	-0.1	-1.9	-0.6	-0.2	-1.2	-2.4	-0.0	-2.9	0.3	-1.7	-1.3	-1.4	-1.5	-2.3	-3.0	0.8	-1.9
Number of live births	1.4	2.0	6.0	-1.1	-0.5	-1.3	0.2	-0.7	-1.6	-1.2	-1.5	-2.4	-0.9	-1.6	-1.3	-1.7	-0.7	-1.5	-2.2	0.4	-1.8
Hair/balding pattern: Pattern 4	1.4	3.4	6.7	2.4	0.9	2.3	1.3	-0.6	1.9	2.3	-0.2	1.6	0.5	2.6	1.8	1.9	2.3	2.3	2.2	1.3	2.0
Blood clot in the leg (DVT)	1.4	1.9	6.8	1.2	0.8	1.9	-0.1	0.8	1.4	1.3	1.3	2.6	0.6	1.6	1.3	1.6	0.8	0.5	1.4	-1.3	1.8
Number of children fathered	1.4	1.5	8.0	0.3	1.6	0.8	-1.5	2.8	0.4	0.5	1.7	0.9	2.5	0.9	-1.0	-0.1	-0.5	-0.8	0.5	0.3	0.6
Pulse wave peak to peak time	1.4	1.7	4.0	-1.1	-1.3	-1.6	-1.1	-0.7	-1.5	-1.2	-2.0	-0.3	-1.4	-2.0	-0.2	-1.7	-0.2	-0.7	-1.4	0.5	-1.8
Hypertension (Self-reported)	1.4	4.0	8.2	-2.0	-0.3	-2.3	-1.9	-1.7	-2.2	-2.1	-2.1	-2.7	-0.5	-2.3	-0.4	-1.8	-2.2	-1.5	-2.9	1.8	-2.7
Qualifications: nursing, teaching	1.4	2.2	7.1	-1.4	-0.4	-1.9	0.6	-2.0	-1.6	-1.5	-2.7	-1.5	-2.1	-1.3	-1.1	-1.9	-0.3	-0.5	-0.4	-1.2	-1.7
Pack years of smoking	1.4	2.0	6.6	-1.7	-1.1	-0.8	-2.0	-0.3	-1.1	-1.8	0.6	-0.5	1.1	-1.5	-1.1	-1.1	-2.0	-2.6	-1.8	0.3	-1.6
Sensitivity / hurt feelings	1.3	2.3	6.4	-1.9	0.4	-1.2	-2.3	-0.7	-1.5	-1.8	-0.7	-2.1	0.3	-1.5	-0.6	-1.7	-1.7	-1.2	-2.5	0.9	-1.5
Forced vital capacity (FVC), Best measure	1.3	4.9	21.4	-1.9	-1.1	-2.3	1.9	-3.6	-1.9	-2.0	-4.2	-0.9	-4.6	-2.0	0.8	-1.5	-0.2	-0.7	-1.3	-0.0	-2.2
Eye problems/disorders: None of the above	1.3	1.5	3.0	1.3	1.2	1.4	-0.2	1.3	1.0	1.3	1.6	1.5	1.3	1.1	1.5	0.6	0.6	0.9	1.2	1.7	0.9
Illnesses of father: Heart disease	1.3	1.8	3.5	1.6	0.7	1.9	-0.0	0.2	1.5	1.4	1.1	1.4	0.9	1.7	1.9	1.3	1.1	1.3	1.6	0.5	1.8
Mood swings	1.3	2.3	7.0	-2.4	-0.9	-1.5	-0.3	0.2	-0.8	-2.3	0.2	-1.9	0.1	-1.7	-1.5	-0.6	-1.8	-2.2	-2.6	-0.4	-1.7
Breast cancer (self-reported)	1.3	1.6	3.7	-1.6	-0.8	-1.3	-0.8	-1.0	-1.3	-1.6	-0.9	-0.6	-1.1	-1.4	-0.8	-1.1	-1.9	-1.6	-1.6	-1.1	-1.2
Cholesterol lowering medication	1.3	1.9	7.2	-1.3	0.6	-0.2	-2.3	0.7	0.0	-1.3	1.1	-0.4	2.0	-0.4	-1.6	-0.5	-2.6	-2.7	-1.0	-0.7	-0.2
Neuroticism (Nagel 2018)	1.2	2.9	7.6	-2.5	-0.1	-1.9	-1.1	-0.6	-1.2	-2.6	-0.3	-2.2	0.2	-1.7	-1.2	-1.1	-1.8	-2.3	-2.8	1.1	-2.1
Triglycerides	1.2	2.0	5.5	-1.2	-1.6	-1.3	-0.8	-1.2	-1.8	-1.1	-2.2	-1.6	0.1	-1.1	-1.7	-1.8	-1.5	0.2	-0.5	-2.3	-0.6
Blood White Count	1.2	8.8	26.2	-1.9	-1.8	-2.2	1.0	-5.0	-3.5	-2.4	-3.2	-1.2	-5.1	-4.1	4.3	-1.8	1.2	-0.3	-1.8	2.5	-3.9
Systolic blood pressure, automated reading	1.2	3.6	7.5	-1.0	-1.8	-2.3	0.0	-2.7	-2.3	-1.2	-2.2	-2.6	-2.2	-2.6	0.9	-1.2	-0.9	0.3	-1.7	2.4	-2.5
High blood pressure	1.2	3.3	6.9	-1.7	-0.2	-2.0	-2.0	-1.4	-2.1	-1.8	-1.7	-2.6	-0.5	-2.2	-0.1	-1.5	-2.0	-1.1	-2.6	2.1	-2.4
Chronic bronchitis/emphysema (mother)	1.2	1.5	5.7	0.8	1.1	1.1	0.7	1.2	1.1	0.7	2.0	2.1	2.4	0.9	0.6	0.8	0.1	-0.6	1.0	1.1	1.0
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.0	1.7	0.1	1.1	1.4	0.6	1.5	1.8	0.9	-0.1	1.0	1.4	0.4	2.0	1.0	1.3	0.8	-0.3	1.4
Worry (Nagel 2018)	1.1	2.3	5.2	-2.1	0.3	-1.6	-1.4	-0.1	-1.3	-2.1	-0.3	-2.2	0.4	-1.3	-1.5	-1.5	-1.4	-2.1	-2.3	1.1	-1.7
Blood Platelet Count	1.1	12.9	29.9	-3.4	-3.7	-4.4	2.5	-5.2	-4.4	-3.7	-3.2	-2.2	-5.3	-5.5	1.6	-2.8	-0.9	-1.2	-3.0	0.8	-5.1
Allergy or Eczema	1.1	2.8	6.3	2.1	1.1	2.0	0.7	0.7	1.8	2.1	0.7	1.0	0.6	2.5	1.4	1.5	2.0	1.7	2.4	-1.2	2.5
Angina	1.1	1.4	3.2	-1.3	-0.9	-1.3	-1.6	-1.8	-1.2	-1.4	-1.6	-0.5	0.1	-1.3	-0.4	-0.9	-1.4	-0.9	-1.4	0.3	-1.2
Pack years adult smoking proportion	1.1	1.7	4.9	-1.5	-0.8	-0.6	-2.2	-0.0	-0.9	-1.6	0.7	-0.2	1.4	-1.3	-0.7	-1.0	-1.8	-2.2	-1.7	0.7	-1.4
Average weekly fortified wine intake	1.1	1.3	3.6	1.2	1.0	0.9	1.4	-0.7	1.0	1.2	0.0	1.5	-0.4	1.3	1.9	1.9	1.4	1.0	0.8	0.1	1.0
Serious illness, injury or assault to yourself	1.1	1.3	4.6	1.0	1.7	0.7	-2.0	-0.2	0.8	0.9	0.9	1.4	-0.0	0.3	2.1	1.3	1.6	0.4	1.1	1.1	0.1
Chronic bronchitis/emphysema (father)	1.1	1.3	3.2	1.1	1.0	0.9	0.6	0.8	1.4	1.1	1.8	1.6	0.8	1.2	1.0	1.5	1.2	0.8	1.1	0.1	1.1
Forced vital capacity (FVC)	1.1	4.3	14.0	-2.4	-0.3	-2.5	1.3	-2.9	-1.9	-2.4	-3.7	-1.3	-3.5	-1.8	-0.1	-2.1	-1.0	-1.3	-1.7	-0.7	-2.0
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	5.6	-1.6	-0.5	-1.3	-0.4	-1.3	-1.0	-1.6	-1.5	-2.4	-0.9	-1.2	-1.1	-1.3	-1.1	-0.6	-2.2	0.5	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	11.9	-1.8	-0.5	-2.0	1.6	-2.9	-1.6	-1.9	-3.4	-1.6	-3.4	-1.6	0.7	-1.6	-0.1	-1.0	-1.3	0.3	-1.9
Pulse wave Arterial Stiffness index	1.1	1.3	3.2	0.9	1.4	1.2	1.4	0.5	1.5	0.9	1.7	0.0	1.1	1.8	0.0	1.7	0.0	0.2	1.0	-0.4	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.1	0.6	1.7	1.3	-1.0	1.8	1.2	0.5	2.0	-0.3	2.0	1.5	0.5	0.5	0.1	-0.5	-0.2	0.9	1.3
Miserableness	1.1	1.9	7.4	-1.4	-0.5	-1.6	-0.6	-1.1	-0.7	-1.7	-0.7	-2.4	-0.4	-1.4	0.1	-0.8	-0.6	-1.2	-2.7	1.5	-1.9
Myopia	1.1	1.6	3.8	-0.9	-0.9	-1.5	-0.4	-1.9	-1.3	-1.1	-1.2	-1.9	-1.7	-1.4	0.3	-0.6	-1.1	-0.3	-1.8	1.1	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	4.0	0.9	1.2	1.5	-0.4	1.5	1.4	1.0	1.9	0.8	2.0	1.4	0.3	1.4	-0.2	0.4	0.5	0.2	1.4
Supplements: Calcium	1.1	1.2	3.5	-0.7	-1.8	-0.9	0.2	-1.1	-1.0	-0.7	-1.6	-0.6	-0.9	-0.6	-1.6	-1.3	-1.2	-0.5	-0.5	-1.9	-0.4
Alzheimer’s Disease (including proxy)	1.0	1.4	4.7	1.0	0.4	1.8	-1.0	0.9	1.4	1.1	0.2	1.5	1.2	1.9	-0.5	0.7	-0.0	0.5	1.3	-1.5	2.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.7	1.3	0.2	1.6	0.5	0.9	1.5	1.4	0.8	1.0	0.2	1.2	1.2	1.6	1.3	1.6	1.2	0.1	1.4
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	9.7	-2.1	-0.0	-2.2	1.0	-2.4	-1.6	-2.2	-3.1	-2.0	-2.7	-1.5	0.0	-2.0	-0.6	-1.4	-1.7	-0.3	-1.8
Glaucoma (self-reported)	1.0	1.2	3.7	-0.9	-1.4	-1.0	1.5	-1.9	-0.4	-0.9	-1.7	-0.4	-1.4	-0.7	-0.9	0.6	-0.8	-0.6	-0.9	-1.1	-0.4
Mineral and other dietary supplements	1.0	1.3	4.8	0.7	1.8	1.2	-0.4	1.8	0.9	0.6	2.2	1.0	1.5	1.0	0.8	1.4	0.6	-0.3	0.3	1.2	0.8
Medication: Atorvastatin	1.0	1.3	7.3	-0.4	0.4	0.3	-2.7	-0.3	0.4	-0.3	-0.3	0.8	2.0	0.3	-1.0	-0.2	-1.8	-1.2	-0.6	-1.9	0.7
Alcohol drinker status: Never	1.0	1.2	2.8	-1.1	-0.6	-1.3	1.2	-0.4	-1.3	-1.3	-0.2	-1.6	-0.7	-1.3	-0.4	-1.2	-0.5	-1.4	-1.7	0.6	-1.4
Depressed Affect (Nagel 2018)	0.9	2.0	5.5	-1.9	-0.7	-1.5	-0.7	-0.9	-0.4	-2.1	-0.0	-1.7	-0.1	-1.5	-0.1	-0.3	-1.0	-2.2	-2.3	1.8	-2.0
Prostate Cancer	0.9	1.3	5.9	-0.0	-1.9	-0.2	1.2	-1.3	-0.9	-0.2	-0.5	-0.1	-2.4	-1.3	1.4	-0.2	1.1	0.7	-0.3	1.8	-1.2
Crohns Disease (2012)	0.9	1.4	3.4	1.3	0.0	1.4	1.2	1.8	1.1	1.4	1.7	1.7	0.7	1.0	0.5	1.5	0.4	1.1	1.2	0.1	1.3
Neuroticism (2016)	0.9	1.2	3.9	-1.6	-0.6	-1.3	-0.3	-0.3	-0.6	-1.6	-0.0	-1.1	-0.9	-1.8	-0.4	-0.3	-1.3	-1.2	-2.0	-0.6	-1.4
Relative age of first facial hair	0.9	1.8	5.0	-0.9	-2.1	-1.4	-0.9	-1.6	-1.1	-0.8	-2.2	-1.4	-1.2	-1.1	-1.5	-1.5	-1.1	0.9	-0.2	-1.8	-0.7
Ever had hysterectomy (womb removed)	0.9	1.1	2.8	-0.7	-0.2	-0.9	-1.0	0.3	-1.3	-0.8	0.0	-1.6	-0.1	-1.2	-0.6	-1.4	-1.4	-1.7	-1.4	0.4	-1.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.8	0.5	-0.3	-0.4	0.3	-1.9	-0.4	0.4	-0.8	-0.5	-1.6	-0.1	1.3	-0.3	1.7	1.6	1.0	-1.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.8	1.2	0.0	1.0	1.7	0.0	1.8	1.1	0.3	1.2	0.5	1.1	1.1	2.0	1.3	0.7	0.3	0.6	0.9
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	4.2	-1.1	-0.3	-0.8	0.1	-0.4	-1.1	-1.1	-0.3	-2.0	-0.9	-1.3	-0.7	-1.1	-1.1	-1.1	-1.4	-0.5	-1.1
Stomach or abdominal pain in last month	0.9	1.2	3.6	-0.4	-1.0	-0.8	-0.3	-1.5	-0.8	-0.5	0.1	-0.3	-1.5	-1.5	1.5	0.3	-0.5	-0.5	-1.5	1.9	-1.6
Pulse rate	0.9	1.5	5.1	1.2	2.2	1.4	1.4	0.7	1.2	1.0	1.7	1.1	0.4	1.4	1.4	1.1	1.5	0.3	1.0	0.4	1.0
Exposure to tobacco smoke at home	0.9	1.0	2.8	-1.7	0.0	-0.5	-1.3	-0.8	-0.8	-1.5	-0.2	-0.9	-0.5	-1.0	-0.7	-0.1	-1.4	-0.7	-1.6	-1.3	-0.7
Birth weight	0.9	2.0	6.3	1.4	1.3	1.6	0.2	0.2	2.5	1.3	-0.3	1.7	0.8	1.9	2.1	2.0	1.5	1.0	1.0	0.8	1.4
Qualifications: College or University degree	0.9	2.9	12.6	-0.7	-1.0	-1.6	0.4	-2.9	-1.6	-0.9	-3.6	-1.6	-2.6	-1.7	0.7	-1.6	0.2	-0.0	-1.2	1.1	-2.2
Suffer from ‘nerves’	0.9	1.4	8.2	-0.5	1.9	-0.1	-0.1	0.8	-0.1	-0.8	1.4	-1.1	0.6	-0.4	0.3	-0.2	0.3	-1.8	-2.0	2.9	-1.1
Osteoarthritis (self-reported)	0.9	1.1	4.7	1.1	0.1	0.9	-0.8	-0.2	1.0	0.9	0.5	1.5	0.1	0.4	1.9	1.1	1.4	1.0	1.0	2.2	0.2
Basal cell carcinoma (self-reported)	0.9	1.1	3.3	0.8	0.5	1.3	-0.7	0.6	1.0	1.0	0.4	1.8	0.7	0.9	1.0	1.5	0.2	1.7	1.4	-0.3	1.2
Ovarian Cancer	0.8	1.0	6.2	0.7	-0.2	0.2	2.5	-0.5	0.4	0.5	0.8	0.9	-1.1	-0.1	0.9	0.6	2.0	-0.1	0.7	1.4	-0.7
Age at First Birth	0.8	1.2	3.2	-1.3	1.0	-1.2	-1.3	-0.2	-1.2	-1.2	-1.5	-0.7	0.1	-0.4	-1.8	-1.5	-1.2	-1.3	-0.6	-0.8	-0.2
Hearing difficulty/problems: Yes	0.8	1.1	3.7	0.9	0.2	0.3	1.6	-1.1	0.7	0.8	0.6	-0.2	-1.3	0.0	1.9	1.2	1.7	1.1	1.1	1.6	-0.1
Medication: Atenolol	0.8	0.9	5.0	-0.5	0.0	-0.3	-2.2	-0.4	-0.6	-0.5	-0.6	-0.4	0.3	-0.7	-0.4	-0.3	-1.4	-1.1	-1.6	1.7	-0.9
Past tobacco smoking	0.8	1.4	6.5	0.2	0.5	-0.5	0.3	0.0	-0.4	-0.1	0.8	-1.8	-1.3	-1.1	1.7	-0.3	2.0	-0.1	-1.5	2.5	-1.5
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.8	0.8	0.8	1.2	-1.0	1.2	1.3	0.9	0.8	-0.7	1.6	0.8	0.1	1.1	0.7	0.2	0.2	1.7	0.9
Headache pain in last month	0.8	1.4	3.0	-1.0	-1.7	-0.8	0.7	-1.0	-1.2	-1.1	-0.9	-1.7	-1.3	-1.7	-0.4	-1.0	-0.3	-1.0	-1.7	-0.2	-1.5
Gout (self-reported)	0.8	1.0	3.7	0.7	1.0	0.9	1.2	-0.2	0.8	0.6	0.4	1.6	-0.8	0.5	1.9	1.5	0.7	0.8	0.4	1.7	0.4
Angina (self-reported)	0.8	1.0	3.2	-1.1	-1.0	-1.2	-1.0	-1.8	-1.1	-1.1	-1.6	-0.4	-0.0	-1.1	-0.2	-0.9	-1.1	-0.6	-1.1	0.1	-0.9
Medication: Omeprazole	0.8	1.0	4.6	0.4	1.4	0.8	-0.7	1.5	0.8	0.4	2.0	0.1	2.2	0.8	0.1	0.6	-0.5	-0.5	-0.1	0.6	0.7
Pulse rate, automated reading	0.8	2.6	6.7	-1.8	0.2	-1.9	1.0	-1.9	-2.3	-2.0	-1.7	-1.7	-0.8	-1.5	-1.1	-2.6	-1.4	-1.4	-1.2	-1.7	-1.3
Comparative height size at age 10	0.8	4.4	15.4	-2.2	1.4	-2.1	2.6	-1.0	-0.4	-2.6	-1.2	-0.8	-1.9	-1.8	-0.6	-0.2	-1.1	-3.9	-3.5	2.3	-3.0
Supplements: Vitamin C	0.8	1.0	3.0	0.4	0.3	0.8	-0.5	1.3	0.9	0.6	0.6	0.4	1.7	1.1	-1.4	0.6	-0.8	-0.1	0.7	-1.7	1.6
Illnesses of siblings: Diabetes	0.8	0.9	3.0	-0.3	-0.5	-0.7	-0.3	0.2	-1.5	-0.5	0.7	-1.6	-1.4	-1.4	0.2	-1.0	1.1	-0.5	-0.6	0.9	-1.7
Long-standing illness, disability or infirmity	0.8	1.2	5.5	1.0	1.1	1.1	0.3	-1.0	1.3	0.8	1.2	0.6	0.1	0.5	2.1	2.4	1.1	0.3	0.4	1.3	0.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.9	-1.4	-0.7	-1.2	1.1	-1.4	-1.8	-1.4	-0.6	-0.2	-2.0	-1.1	0.5	-1.0	-0.7	-0.3	-0.5	-1.5	-1.0
Back pain experienced in last month	0.8	1.2	4.3	-1.6	-0.0	-1.1	0.1	-0.0	-0.8	-1.4	-0.5	-0.7	0.6	-1.0	-1.6	-0.8	-1.3	-2.1	-1.5	0.9	-1.0
Hearing aid user	0.8	0.9	3.3	0.5	-0.6	0.9	1.8	-0.2	0.9	0.6	1.3	0.7	-0.5	0.6	1.3	1.4	0.3	1.2	0.7	-0.5	1.1
Financial situation satisfaction	0.8	1.0	3.0	-1.5	0.5	-0.9	-1.7	0.3	-1.1	-1.2	-0.2	-0.3	0.2	-0.8	-1.2	-1.0	-1.4	-0.6	-0.8	-1.5	-0.4
Ever smoked	0.8	1.4	6.0	-0.5	0.3	0.1	-1.0	0.8	-0.2	-0.3	-0.4	1.1	1.6	0.8	-2.5	-0.7	-2.1	-1.0	0.6	-2.2	0.9
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.7	1.1	-0.2	1.5	2.1	1.2	1.5	1.3	1.2	2.2	0.0	1.7	-0.3	1.0	1.3	0.8	2.1	-2.1	2.0
Pain experienced in last month	0.8	1.3	4.3	1.3	1.1	0.9	-1.1	0.7	1.0	1.2	0.4	1.4	0.1	1.4	1.0	0.6	1.3	1.1	2.1	-0.9	1.4
Bipolar Disorder (2018)	0.7	1.1	6.0	0.5	0.5	0.1	-2.5	1.3	-0.0	0.6	0.1	-1.1	2.0	1.0	-1.5	-0.6	0.2	0.0	0.4	-0.8	0.8
Bipolar Disorder or Schizophrenia	0.7	1.8	10.2	-0.5	0.8	-0.4	-3.2	1.0	-0.7	-0.3	-0.3	-0.4	2.9	0.3	-2.0	-1.4	-1.2	-0.9	0.2	-1.4	0.2
Alzheimer’s Disease (in father)	0.7	0.8	9.0	0.2	-0.3	0.1	-3.0	-0.3	0.5	0.2	-0.4	-0.2	1.8	0.5	-0.5	0.1	-0.7	-0.0	0.1	0.2	0.3
Fasting Glucose	0.7	0.8	3.9	0.4	-0.8	-0.3	0.8	-2.0	-0.7	0.2	-1.7	-0.9	-0.9	-0.1	1.4	-0.3	0.3	0.5	-0.3	0.9	-0.4
LDL Cholesterol	0.7	1.1	3.5	-0.6	0.8	0.4	0.3	1.6	0.4	-0.3	0.8	1.4	1.7	0.8	-1.9	-0.4	-1.4	-0.6	0.4	-1.7	1.0
Heel T-Score	0.7	5.2	21.1	1.6	3.0	2.1	-2.9	4.0	0.6	1.7	3.6	0.2	4.6	2.6	-0.6	-0.8	0.3	0.5	0.7	-1.0	2.6
Systolic Blood Pressure	0.7	3.6	8.0	-1.0	-0.6	-2.2	-0.3	-2.0	-2.2	-1.3	-1.3	-2.7	-2.4	-2.7	1.3	-1.7	-0.6	-0.3	-2.2	2.8	-2.8
Severe depression (siblings)	0.7	0.7	5.1	-0.7	-0.1	-0.4	0.0	-0.1	-0.1	-0.6	-0.6	-1.0	0.8	0.4	-1.6	-0.6	-1.1	-0.5	-0.6	-2.3	0.5
Illnesses of siblings	0.7	0.9	4.3	0.4	0.8	0.9	0.4	1.1	1.4	0.5	0.7	1.3	2.1	1.2	-0.5	0.7	-0.4	0.1	0.8	0.4	1.3
Alcohol intake versus 10 years previously	0.7	1.0	3.7	-0.8	0.5	-0.9	1.0	-0.4	-0.2	-1.0	-0.0	-1.1	-1.0	-1.5	0.4	0.4	0.1	-1.1	-1.4	1.9	-1.6
Father’s age at death	0.7	0.9	5.9	-0.1	0.3	-0.0	-0.3	-1.5	0.1	-0.4	-0.3	0.9	-1.4	-0.5	2.4	0.2	0.9	-0.2	-0.1	1.6	-0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.6	-0.8	-1.0	-1.1	1.6	-1.3	-1.4	-0.9	-2.4	-1.1	-2.3	-0.9	-0.7	-1.8	0.1	-0.4	-0.7	-0.7	-1.3
Mouth/teeth dental problems: Dentures	0.7	1.2	4.5	1.1	2.1	0.8	-0.4	0.6	0.8	1.0	1.6	0.7	-0.0	0.5	1.7	1.3	1.2	0.1	0.7	1.7	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	4.6	0.2	0.4	0.6	1.6	-1.0	0.1	0.0	-0.5	0.3	-1.1	0.5	2.1	0.3	1.9	1.0	0.3	0.1	-0.0
Tense / ‘highly strung’	0.7	1.1	3.8	-1.8	-1.1	-1.0	-0.4	-0.2	-0.9	-1.7	-0.1	-1.3	-0.0	-1.1	-0.7	-0.3	-1.3	-0.8	-2.0	-0.3	-0.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.2	-1.3	0.4	-0.4	-1.8	0.0	-0.3	-1.2	1.0	-1.0	-0.0	-0.9	-0.3	0.0	-1.4	-1.0	-1.7	0.4	-1.1
Exposure to tobacco smoke outside home	0.7	0.9	4.5	0.2	2.1	1.0	-0.8	1.6	0.9	0.2	1.7	-0.5	1.2	0.8	0.3	0.5	0.4	-0.3	0.0	0.2	0.8
Health satisfaction	0.7	0.9	3.2	-0.9	1.0	-0.9	0.3	-0.4	-0.7	-1.0	0.1	-0.5	-0.0	-1.1	0.7	-0.2	-0.8	-1.5	-1.2	1.8	-1.6
Neck or shoulder pain in last month	0.7	0.9	3.6	-1.1	0.1	-0.5	0.5	-0.5	-1.1	-1.1	-0.0	-0.6	-0.8	-1.3	0.5	-0.2	-0.9	-1.2	-1.9	1.1	-1.5
Medication: Seretide 50 evohaler	0.7	0.8	3.1	0.8	0.8	0.4	-1.8	0.2	0.8	0.8	1.5	0.0	0.9	0.6	1.4	0.7	1.4	1.0	0.3	0.1	0.5
Had major operations	0.7	0.8	2.0	0.9	0.9	0.7	1.3	1.2	0.6	0.8	0.9	0.2	0.8	1.1	-0.2	0.2	1.4	0.6	1.0	-0.7	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	4.0	1.1	0.8	0.8	0.1	0.5	0.3	1.1	1.1	0.9	0.4	0.3	2.0	0.9	1.3	1.0	0.3	1.2	0.2
Average weekly red wine intake	0.7	1.0	2.8	-1.2	1.0	-1.4	-0.1	0.2	-1.3	-1.2	-1.7	-1.0	0.7	-0.7	-1.1	-1.4	-0.7	-0.4	-0.8	-0.6	-0.6
Loneliness, isolation	0.7	1.0	4.4	0.8	1.2	1.0	-0.4	1.1	1.4	0.7	1.1	-0.2	1.1	1.0	0.7	1.3	0.6	-0.5	-0.3	2.1	0.3
Ever had bowel cancer screening	0.7	0.8	4.0	0.1	-1.6	-1.0	0.5	-2.0	-0.7	-0.1	-1.2	-0.4	-1.4	-0.4	0.7	-0.5	-0.7	-0.2	-0.5	0.8	-0.8
Guilty feelings	0.7	1.0	4.7	-0.2	0.2	0.4	0.6	1.2	0.3	0.1	0.4	-0.3	1.7	1.0	-1.9	0.2	-1.3	0.2	0.1	-2.2	1.4
Number of operations (self-reported)	0.7	1.1	4.3	-0.9	0.3	-0.9	-0.6	0.0	-0.8	-1.2	0.8	-1.1	0.2	-1.4	0.2	-0.7	-0.4	-2.1	-1.5	1.2	-1.7
Heart disease (siblings)	0.7	0.9	3.9	-0.4	-1.4	-0.7	-0.7	-1.1	-1.4	-0.3	-2.0	-1.0	-1.0	-0.6	-0.5	-1.0	-0.7	0.6	0.0	-1.0	-0.3
Schizophrenia (2018)	0.6	1.2	4.4	-1.0	0.6	-0.6	-2.0	0.3	-0.9	-0.9	-0.5	0.4	2.1	-0.4	-1.4	-1.3	-1.7	-1.2	-0.1	-1.2	-0.4
Lupus	0.6	0.9	4.0	-1.3	-0.3	-0.7	-0.6	0.2	-1.0	-1.2	0.7	-0.2	-0.8	-1.1	-0.8	-0.5	-1.3	-0.5	-2.0	-0.7	-0.8
Ulcerative Colitis	0.6	0.9	2.3	-0.5	-1.3	-1.3	-0.8	-0.9	-1.2	-0.5	-0.7	-1.4	-0.8	-1.5	0.3	-0.8	-0.3	0.3	-0.6	0.5	-1.4
Waist Hip Ratio (WHR)	0.6	2.7	7.4	-0.1	1.8	-0.7	2.0	-1.7	-1.7	-0.7	0.8	-1.4	-2.4	-1.6	2.7	-0.6	1.8	-1.0	-0.9	2.7	-2.1
Qualifications: CSEs or equivalent	0.6	0.8	2.4	-0.8	-0.1	-0.6	0.4	1.2	-0.4	-0.7	0.6	-0.5	1.1	-0.5	-1.6	-0.8	-1.5	-1.5	-0.7	-0.2	-0.2
Medication: Levothyroxine sodium	0.6	1.0	3.8	1.5	-0.4	0.3	0.0	0.7	1.0	1.3	2.0	1.1	0.3	-0.0	1.7	1.0	1.6	0.3	0.5	0.9	0.0
Waist circumference	0.6	2.2	6.4	-1.4	1.5	-1.6	1.3	-1.9	-1.4	-1.6	-0.7	-1.4	-2.0	-2.0	0.8	-0.1	-0.1	-1.2	-1.5	1.7	-2.5
Alcohol usually taken with meals	0.6	0.9	3.0	-0.9	-0.4	-0.9	-0.7	0.1	-1.0	-1.0	-0.2	-1.4	-0.3	-1.6	-0.2	-0.8	-0.3	-0.8	-0.9	1.7	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.4	0.2	1.1	0.8	-0.5	1.8	1.3	0.3	1.4	0.2	1.7	1.0	-0.4	1.3	0.1	-1.0	-0.5	0.3	0.8
Diabetes (self-reported)	0.6	0.9	4.8	0.4	0.9	0.8	-2.2	0.5	1.3	0.5	1.2	0.6	1.3	0.6	0.2	1.2	0.5	0.0	1.1	0.4	0.7
Pulse wave reflection index	0.6	0.7	3.6	0.3	0.8	0.7	-0.9	0.7	0.8	0.4	1.9	-0.4	1.5	1.2	-0.1	0.5	-0.3	-0.1	0.1	-0.8	1.1
Comparative body size at age 10	0.6	1.8	13.8	0.7	-0.4	0.3	0.4	-0.8	0.2	0.5	-0.2	1.8	-1.7	-0.4	3.7	1.4	1.5	0.3	0.3	2.2	-0.9
Age at first live birth	0.6	1.0	3.2	1.0	0.5	0.8	-1.2	-0.3	1.3	0.9	-0.6	1.8	0.6	1.5	0.5	0.7	0.7	0.6	1.4	-0.4	1.2
Medication: Blood pressure	0.6	1.0	2.9	-1.5	0.7	-1.0	-1.1	-1.0	-0.5	-1.6	-1.0	-1.0	-0.0	-0.8	-0.5	-0.0	-1.1	-1.7	-1.4	0.4	-1.0
Medication: Ibuprofen	0.6	0.8	4.6	0.4	0.9	1.0	1.2	-0.0	0.5	0.2	0.4	0.8	-0.7	0.6	2.1	0.8	1.6	0.5	0.0	0.6	0.1
Alcohol intake frequency.	0.6	1.4	5.6	-1.1	-0.7	-0.7	0.0	-0.5	-0.6	-1.2	1.4	-1.8	-0.7	-1.9	1.0	0.2	-0.1	-1.1	-2.4	1.1	-1.6
Number of self-reported non-cancer illnesses	0.6	1.0	5.8	0.6	1.3	0.6	-1.1	-0.7	0.6	0.4	1.7	0.1	0.5	-0.1	2.4	1.4	0.7	-0.1	-0.5	1.4	-0.3
Commuting to job workplace: Public transport	0.6	0.7	1.9	-0.5	-0.6	-0.5	-0.0	-0.5	-0.7	-0.5	-1.0	-1.0	0.4	0.3	-1.2	-1.4	-1.3	-0.9	-0.7	-1.1	0.2
Illnesses of father: High blood pressure	0.6	0.8	4.2	0.5	0.6	0.8	1.2	0.0	0.7	0.5	0.5	0.8	-0.6	0.1	1.5	1.6	0.6	0.3	0.0	2.1	-0.1
Risk taking	0.6	0.9	2.3	1.5	0.2	0.9	-0.7	0.8	1.1	1.5	0.7	-0.0	0.9	1.0	0.2	0.7	1.2	1.3	1.0	-0.4	1.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.5	1.2	1.0	0.9	0.6	-0.3	0.5	1.1	0.2	0.6	0.1	0.8	1.2	0.4	1.2	0.9	0.9	0.1	0.6
HbA1C	0.5	0.5	3.1	-0.5	0.7	-0.3	-0.7	0.1	-0.5	-0.4	0.1	-0.8	1.4	0.2	-0.6	-1.0	-1.8	-0.4	-0.4	-0.5	0.4
Schizophrenia (2014)	0.5	1.2	4.4	-0.9	0.3	-0.4	-2.1	0.4	-0.9	-0.7	-0.3	0.1	2.0	-0.3	-1.5	-1.4	-1.9	-0.8	-0.3	-1.3	-0.2
Blood Eosinophil Count	0.5	4.2	17.8	-1.4	2.1	-1.4	0.1	-0.3	-0.3	-1.9	2.0	-2.2	-1.3	-2.6	2.1	0.6	0.3	-1.8	-2.8	4.2	-3.5
Chronotype (morning person)	0.5	1.3	2.9	-1.1	-1.6	-1.4	1.2	-1.0	-0.8	-1.1	-0.8	-1.3	-0.9	-1.3	-0.9	-1.1	-1.3	0.2	-1.1	-1.7	-0.4
Medication: Co-codamol	0.5	0.6	2.5	0.0	1.6	0.2	-1.2	0.8	0.3	0.1	0.9	0.1	1.3	0.1	0.1	0.5	-0.7	-0.5	-0.1	1.5	0.1
Medication: Metformin	0.5	0.7	3.2	0.4	0.7	0.9	-1.8	-0.1	0.9	0.5	0.7	0.9	0.3	0.6	0.6	1.4	0.6	0.5	1.3	0.4	0.5
Trunk fat percentage	0.5	2.2	8.8	-1.3	-0.7	-1.3	1.5	-2.6	-1.5	-1.3	-1.7	-0.8	-3.0	-2.0	0.6	0.0	0.3	0.6	-0.9	-0.0	-2.1
Townsend deprivation index at recruitment	0.5	0.8	3.3	0.4	-0.5	0.1	0.7	-1.2	0.5	0.2	-0.4	0.7	-1.5	-0.3	1.8	1.1	1.4	-0.1	0.2	1.2	-0.6
Taking other prescription medications	0.5	0.8	3.4	0.2	1.8	0.4	-0.9	0.5	0.6	0.1	1.5	0.7	1.0	0.2	1.4	1.2	0.1	-0.9	-0.6	0.5	0.0
Trunk fat mass	0.5	2.3	9.8	-1.4	-0.1	-1.4	2.1	-2.4	-1.1	-1.5	-1.7	-0.8	-3.1	-1.9	0.3	0.4	0.0	-0.2	-1.1	0.5	-2.2
Financial difficulties in last 2 years	0.5	0.7	6.1	0.2	0.8	0.3	-2.5	0.7	0.0	0.3	1.1	-0.5	0.7	-0.3	0.4	-0.2	0.4	0.3	-0.3	1.3	-0.4
Heart attack	0.5	0.6	2.0	-0.3	0.0	0.6	-1.3	0.5	0.9	-0.2	0.6	0.7	0.8	0.4	-1.1	0.8	-1.0	-0.6	-0.2	-1.4	0.8
Weight	0.5	2.4	6.0	-1.6	1.3	-1.4	2.3	-1.4	-0.4	-1.7	-1.2	-1.0	-2.5	-1.6	0.0	0.7	-0.6	-1.6	-1.7	1.7	-2.4
Falls in the last year	0.5	0.6	1.7	-1.1	1.2	-0.3	-0.7	0.2	-0.3	-1.0	0.3	0.6	0.6	-0.6	-0.1	-0.1	-1.3	-1.3	-0.9	1.1	-0.8
Length of working week for main job	0.5	0.6	1.8	0.8	1.3	0.4	0.5	1.2	0.5	0.7	1.1	-0.4	1.0	0.5	0.1	0.3	0.4	-0.7	-0.4	1.3	-0.0
Breastfed as a baby	0.5	0.7	2.4	1.3	-0.6	0.8	-0.1	0.5	0.9	1.2	-0.2	0.3	0.7	0.9	0.4	0.4	1.0	0.8	1.6	0.6	0.7
Loud music exposure frequency	0.5	0.6	2.6	0.5	0.4	0.9	-1.6	1.1	0.4	0.5	0.0	0.9	1.1	0.8	-0.3	-0.0	-0.6	0.5	0.3	0.7	0.8
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	4.3	1.4	-0.3	0.5	-0.1	0.4	1.2	1.2	1.1	2.1	0.5	0.4	1.6	1.4	0.9	0.4	0.3	0.3	0.3
Number of full brothers	0.5	0.6	3.9	-0.5	-0.3	-0.8	-2.0	0.4	-1.0	-0.5	-0.1	-0.4	0.2	-1.0	-0.1	-0.8	-0.6	-0.3	-0.7	1.2	-0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.4	0.0	-0.9	-1.1	0.1	-1.6	-0.5	-0.1	-0.4	-0.9	-0.6	-1.1	0.8	-0.0	0.1	0.5	0.0	1.4	-1.1
Heart disease (mother)	0.5	0.6	2.6	-0.3	0.3	-0.4	1.1	-0.4	-1.1	-0.2	-0.5	-0.9	-0.5	-0.3	-1.0	-1.6	-1.2	-0.5	-0.4	-0.1	-0.3
Overall health rating	0.5	1.0	4.6	-0.8	0.9	-0.5	-0.2	-0.5	-0.4	-0.9	0.6	-1.0	0.3	-1.0	0.3	0.0	-0.7	-1.6	-1.9	2.1	-1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	7.6	-0.0	-1.4	0.2	2.8	0.1	-0.1	-0.0	-0.2	0.3	-0.4	0.1	-0.1	0.6	-0.0	0.3	0.1	-0.2	0.3
Knee pain experienced in last month	0.5	0.8	2.5	-1.5	-1.0	-0.8	0.7	-1.6	-0.7	-1.3	-0.9	0.0	-0.2	-0.9	0.1	0.0	-1.6	-0.8	-0.8	-0.2	-0.7
Medication: Aspirin	0.5	0.7	1.9	0.4	0.6	0.7	-1.4	0.3	1.4	0.3	1.3	0.5	0.8	0.5	0.3	1.3	-0.1	-1.4	-0.1	0.5	0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.6	-0.6	0.5	-1.0	-0.2	0.3	-1.2	-0.6	-0.6	-1.2	-0.3	-0.7	-1.1	-1.3	-0.6	-0.5	-0.8	-1.0	-0.7
Ever taken oral contraceptive pill	0.5	0.6	2.1	0.0	-1.5	-0.5	-0.0	-0.4	-0.5	-0.0	-0.3	-1.4	-0.8	-0.8	0.3	-0.4	0.4	0.7	-0.7	1.4	-0.8
High cholesterol (Self-reported)	0.5	0.8	4.1	-0.4	0.2	0.5	-1.9	0.1	0.2	-0.4	0.4	1.1	2.0	0.5	-0.5	0.2	-1.4	-1.5	0.4	-0.6	0.6
Medication: Paracetamol	0.5	0.8	3.0	-1.1	-0.3	-0.4	-1.7	-0.9	-0.9	-1.1	-0.7	-1.4	-0.1	-0.8	-0.3	-0.4	-0.4	-0.5	-1.4	-0.5	-0.8
Average weekly beer plus cider intake	0.5	0.8	2.8	-0.9	-0.5	-1.7	0.6	-0.5	-1.1	-0.8	-0.9	-1.3	-0.2	-0.9	-1.1	-0.9	-0.7	-0.3	-0.6	0.2	-1.2
Fractured/broken bones in last 5 years	0.5	0.6	2.2	0.5	-0.4	1.0	-0.0	0.3	1.0	0.6	0.3	0.7	0.8	1.0	0.4	0.8	0.2	1.5	0.7	-0.7	1.4
Alcohol drinker status: Previous	0.5	0.5	1.6	0.2	-1.1	-0.3	-0.6	-1.2	-0.2	0.1	0.2	-0.3	-0.9	-0.5	0.9	-0.1	0.9	0.9	-0.4	1.3	-0.8
Arm predicted mass (left)	0.5	2.7	9.3	-1.5	2.3	-1.3	2.5	-0.2	0.4	-1.6	-0.7	-1.0	-1.7	-1.0	-0.5	0.6	-1.1	-3.1	-2.1	2.3	-2.2
Breast Cancer	0.4	1.0	3.7	1.4	0.6	0.3	1.7	-0.5	0.7	1.2	-0.2	-1.0	-1.1	0.4	1.1	0.8	1.9	1.6	0.6	0.4	0.2
Height	0.4	8.4	28.0	-2.3	0.2	-2.8	5.3	-2.5	1.0	-2.8	-3.6	-1.0	-5.0	-1.3	-1.6	0.8	-1.3	-4.4	-3.5	2.4	-3.6
Smoking Status	0.4	0.9	2.9	-0.6	-1.1	-0.8	-1.5	-1.7	-0.9	-0.5	-1.7	0.7	0.1	-0.3	-0.3	-0.8	-1.5	0.3	0.5	-0.7	-0.3
Supplements: Zinc	0.4	0.4	1.8	-0.2	-1.0	-0.1	0.6	-1.3	-0.2	-0.2	-0.3	0.5	-1.3	-0.2	0.7	-0.2	0.8	0.6	0.6	-0.6	-0.3
Diabetes (father)	0.4	0.4	3.7	-0.3	0.2	0.4	-0.2	0.4	0.4	-0.5	1.9	0.6	0.2	0.0	0.7	0.2	0.8	-1.0	-0.4	0.6	-0.6
Leg fat-free mass (left)	0.4	2.2	5.2	-1.3	1.8	-1.1	2.2	-0.6	0.6	-1.4	-0.6	-1.1	-1.8	-1.0	-0.1	0.8	-0.8	-2.2	-2.0	2.3	-2.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.7	0.1	0.1	0.4	0.1	0.0	-0.2	0.3	-0.5	0.0	-0.0	0.6	-0.7	-0.0	-0.5	1.3	0.6	-1.6	0.9
High blood pressure (mother)	0.4	0.6	2.3	-0.8	-0.5	-1.1	-0.1	-0.9	-1.0	-0.6	-0.5	-0.6	-0.8	-1.5	0.5	-0.3	-0.7	0.5	-0.5	0.2	-1.0
Leg predicted mass (left)	0.4	2.0	5.2	-1.2	1.8	-1.0	2.1	-0.6	0.6	-1.3	-0.6	-1.0	-1.7	-0.9	-0.0	0.9	-0.7	-2.0	-1.9	2.3	-1.9
Number of incorrect matches in round	0.4	0.6	2.2	-1.0	-0.7	-0.2	1.0	-0.8	-0.6	-0.9	0.4	0.5	-0.5	-1.0	0.2	0.4	-1.5	-0.9	-1.2	0.0	-0.6
Mouth/teeth dental problems	0.4	0.7	3.1	-0.0	-0.7	0.1	-0.8	0.8	0.1	-0.0	-1.2	-0.2	1.4	0.4	-1.7	-1.1	-0.8	-0.2	-0.3	-1.0	0.7
Impedance of arm (right)	0.4	1.9	6.5	-0.7	-2.5	-1.0	0.0	-2.5	-1.4	-1.0	-2.1	-0.4	-2.0	-1.3	-0.6	-1.8	0.1	0.7	-0.7	-1.4	-1.0
Arm fat percentage (right)	0.4	1.7	5.6	-1.3	-0.2	-1.2	1.1	-2.2	-1.6	-1.3	-1.3	-1.0	-2.4	-1.9	0.6	0.1	-0.1	0.5	-0.9	0.0	-1.8
Trunk fat-free mass	0.4	2.3	9.5	-1.0	2.8	-0.7	2.1	0.5	1.2	-1.1	-0.3	-0.7	-0.9	-0.2	-0.8	1.0	-1.2	-3.1	-1.7	2.4	-1.4
Hip circumference	0.4	1.6	3.8	-1.8	1.0	-1.6	0.4	-1.5	-0.9	-1.8	-1.8	-0.7	-1.4	-1.4	-0.4	-0.3	-1.0	-1.1	-1.4	0.2	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.9	-0.2	0.1	-0.7	0.4	0.8	-0.1	-0.1	-0.4	0.2	0.9	0.2	-1.5	-1.0	-0.2	-0.4	0.2	-1.7	0.3
Depression (self-reported)	0.4	0.4	3.0	0.5	0.7	0.0	-0.8	0.1	0.1	0.4	0.1	0.7	0.5	0.1	1.7	0.3	0.9	0.7	0.2	1.0	-0.0
Illnesses of mother	0.4	0.5	2.0	0.7	0.2	0.5	-1.4	0.1	1.0	0.5	0.1	-0.8	0.9	0.8	0.8	0.6	0.9	0.3	-0.1	1.2	0.2
Arm fat mass (right)	0.4	1.7	6.1	-1.3	0.5	-1.2	1.7	-1.9	-1.0	-1.4	-1.0	-0.9	-2.5	-1.7	0.7	0.5	-0.1	-0.3	-1.2	0.9	-2.0
Trunk predicted mass	0.4	2.2	8.7	-1.0	2.8	-0.7	2.2	0.4	1.2	-1.0	-0.3	-0.6	-1.0	-0.2	-0.7	1.0	-1.1	-3.0	-1.7	2.3	-1.4
Standing height	0.4	3.9	14.9	-1.5	1.3	-1.6	3.9	-1.2	1.0	-1.8	-2.1	-0.4	-3.0	-0.7	-1.4	0.2	-0.9	-3.4	-2.2	1.8	-2.4
Medication: Paracetamol	0.4	0.6	2.4	-0.8	-0.8	-0.2	-1.5	-1.3	-0.8	-0.8	-1.0	-1.1	-0.2	-0.6	-0.2	-0.4	-0.0	0.4	-0.9	-0.5	-0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.2	1.1	-0.8	0.9	0.8	1.1	0.7	1.2	0.9	0.8	-0.2	0.4	0.1	0.2	0.7	1.5	0.7	0.2	0.6
Body fat percentage	0.4	1.7	7.0	-1.2	-0.5	-1.0	1.2	-2.3	-1.4	-1.2	-1.3	-0.6	-2.6	-1.9	0.7	0.3	0.2	0.7	-0.7	0.0	-1.9
Arm fat-free mass (right)	0.4	2.1	7.3	-0.9	2.6	-0.6	2.4	0.5	1.0	-1.0	-0.0	-0.4	-1.1	-0.3	-0.2	1.1	-0.7	-2.7	-1.5	2.5	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.8	-0.5	-1.4	-0.8	-0.0	-1.3	-0.7	-0.6	-0.4	-1.2	-0.7	-0.8	0.8	-0.4	0.4	0.3	-0.8	-0.4	-0.6
Medication: Allopurinol	0.4	0.5	2.1	0.0	1.4	0.4	0.7	0.6	0.1	0.0	0.3	1.4	-0.7	0.1	0.6	0.8	-0.1	-0.0	-0.6	1.5	-0.1
Whole body fat mass	0.4	1.7	7.2	-1.3	0.4	-1.0	1.7	-2.0	-0.8	-1.3	-1.0	-0.5	-2.7	-1.7	0.8	0.7	0.1	-0.1	-0.9	0.9	-2.1
Arm predicted mass (right)	0.4	2.0	7.2	-1.2	2.1	-0.9	2.3	0.2	0.8	-1.2	-0.5	-0.9	-1.2	-0.6	-0.6	0.9	-1.0	-2.7	-1.7	2.0	-1.7
Family relationship satisfaction	0.4	0.5	2.1	-0.6	-0.4	0.3	-0.4	1.2	0.7	-0.3	1.1	-0.1	0.9	-0.1	-1.2	0.9	-1.5	-0.3	-0.5	-0.2	0.3
Leg pain on walking	0.4	0.6	2.2	-0.6	1.0	-0.6	-0.2	-0.0	-0.2	-0.6	0.6	-1.3	0.1	-0.7	-0.4	-0.0	-1.5	-0.8	-0.7	1.0	-0.8
Medication: Aspirin	0.4	0.6	2.7	0.1	0.4	0.5	-1.4	0.4	1.1	0.0	1.1	0.5	0.9	0.3	0.1	1.0	-0.4	-1.6	-0.3	0.7	0.3
Whole body fat-free mass	0.4	2.3	8.4	-1.2	2.3	-1.0	2.2	0.1	0.9	-1.4	-0.5	-1.0	-1.3	-0.6	-0.7	0.8	-1.2	-2.9	-2.0	2.3	-1.8
Leg fat-free mass (right)	0.4	2.1	5.9	-1.3	1.8	-1.2	2.1	-0.4	0.4	-1.5	-0.6	-1.4	-1.5	-0.9	-0.5	0.5	-0.9	-2.4	-2.1	2.0	-2.0
Arm fat percentage (left)	0.4	1.5	4.9	-1.3	-0.2	-1.1	1.0	-2.1	-1.5	-1.2	-1.2	-1.0	-2.2	-1.8	0.6	-0.0	-0.1	0.6	-0.8	0.1	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.6	0.3	0.5	0.4	-0.9	-0.3	-0.1	0.3	0.2	0.1	0.3	0.0	1.6	0.1	0.2	0.2	-0.7	1.5	-0.2
Commuting to job workplace: Walk	0.4	0.5	2.0	-0.1	1.0	-0.0	-0.7	-0.2	0.3	-0.3	-0.7	0.3	1.4	0.5	0.3	-0.6	-0.7	-1.0	-0.6	1.0	0.1
Medication for cholesterol	0.4	0.6	2.4	-0.2	-0.1	-0.0	1.5	-1.0	0.1	-0.1	-1.5	0.5	-1.0	0.3	-0.3	0.4	0.5	0.8	0.1	-1.6	0.4
Osteoporosis (self-reported)	0.4	0.5	2.1	-0.4	1.1	0.4	-0.6	-0.1	0.2	-0.3	-0.4	1.4	0.3	0.4	0.2	0.2	-1.4	-0.7	-0.2	-1.1	0.6
Whole body water mass	0.4	2.3	8.5	-1.1	2.4	-0.9	2.4	0.2	0.9	-1.2	-0.5	-0.9	-1.2	-0.5	-0.6	0.9	-1.1	-2.9	-1.9	2.5	-1.7
Leg predicted mass (right)	0.4	2.3	6.3	-1.4	1.8	-1.3	2.2	-0.5	0.4	-1.5	-0.7	-1.4	-1.6	-1.0	-0.4	0.5	-0.8	-2.5	-2.2	2.1	-2.1
Arm fat mass (left)	0.4	1.7	5.9	-1.3	0.6	-1.2	1.6	-1.8	-1.0	-1.4	-1.0	-0.8	-2.4	-1.7	0.8	0.5	-0.1	-0.3	-1.1	1.0	-2.0
Average weekly champagne plus white wine intake	0.4	0.5	2.5	0.0	-0.7	0.0	1.6	-0.9	-0.5	-0.0	-0.5	0.0	-1.6	-0.2	1.1	-0.3	0.4	0.9	-0.0	0.3	-0.0
Mother’s age at death	0.4	0.5	1.8	0.5	-0.7	0.6	-0.8	-0.4	0.1	0.6	-0.6	0.4	-0.8	0.6	0.4	0.3	0.7	1.3	1.2	-1.0	1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.9	0.1	-1.1	-0.6	0.6	-1.1	-0.5	0.1	-1.7	-0.1	-1.2	-0.5	-0.3	-0.7	-0.2	0.7	0.2	-0.1	-0.5
Basal metabolic rate	0.4	2.3	6.4	-1.3	2.1	-1.1	2.5	-0.4	0.6	-1.4	-0.6	-0.9	-1.8	-0.9	-0.3	0.9	-0.9	-2.5	-1.9	2.2	-2.0
Arm fat-free mass (left)	0.4	2.0	6.6	-0.9	2.5	-0.6	2.3	0.2	1.0	-1.0	-0.2	-0.4	-1.3	-0.4	0.0	1.3	-0.7	-2.5	-1.5	2.6	-1.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.7	-0.1	-0.2	0.7	-1.0	0.4	1.0	0.0	0.8	0.8	0.7	0.6	-0.9	0.9	-0.6	-0.5	-0.1	-1.3	0.8
Irritable Bowel Disease (IBD)	0.3	0.8	2.3	1.3	0.4	0.8	-0.8	1.1	0.6	1.3	1.5	0.5	0.7	0.4	1.1	0.8	0.4	1.1	0.8	0.9	0.4
Ulcerative Colitis (UC)	0.3	0.6	3.1	0.3	-0.5	-0.4	-0.8	-0.6	-0.6	0.2	0.3	-0.0	-0.7	-1.1	1.8	0.0	0.5	1.0	0.1	1.1	-1.2
Reaction Time	0.3	0.5	2.1	-0.8	-0.2	-0.8	-0.3	-0.2	-1.1	-0.8	-0.1	-0.2	-0.1	-0.7	-0.9	-0.9	-0.9	-0.4	-0.4	-1.4	-0.6
Bipolar Disorder (2011)	0.3	0.3	1.6	0.1	1.3	0.1	-1.1	0.7	-0.2	0.0	0.3	0.6	0.8	0.5	-0.2	0.0	0.2	-0.9	0.2	-0.3	0.1
Number of treatments/medications taken	0.3	0.6	2.6	-0.6	0.7	-0.5	0.5	-0.8	-0.4	-0.7	0.3	-0.8	-0.3	-0.9	0.6	0.5	-0.2	-1.6	-1.4	0.2	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.0	-0.4	0.8	-0.0	-0.5	0.6	0.4	-0.4	0.2	-0.5	0.9	-0.2	-0.0	0.8	-0.7	-0.8	-1.4	1.2	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.8	-0.5	0.3	-0.3	-0.9	0.7	-0.6	-0.5	1.1	0.1	0.9	0.1	-0.5	-1.0	-0.4	-0.8	-0.1	-1.4	-0.1
Diabetes (mother)	0.3	0.3	0.9	-0.6	0.7	-0.6	0.4	0.5	-0.6	-0.6	0.2	-0.9	-0.2	-0.4	-1.0	-0.6	-0.2	-0.4	-0.6	-0.6	-0.7
Fed-up feelings	0.3	0.6	2.2	-0.8	0.0	-0.0	0.2	0.7	0.6	-0.8	1.5	-0.7	0.8	-0.3	0.1	1.2	-0.5	-0.9	-1.4	0.3	-0.1
Supplements: Glucosamine	0.3	0.4	1.2	-0.6	-1.1	-0.5	-0.6	-0.7	-0.2	-0.5	-1.0	-0.8	0.3	-0.5	-0.9	-0.5	-0.8	0.4	-0.3	-0.3	-0.1
Sitting height	0.3	2.5	8.1	-1.1	1.2	-1.3	2.9	-0.7	0.4	-1.3	-2.1	-0.8	-2.2	-0.5	-1.8	-0.5	-0.8	-2.8	-1.8	1.2	-1.7
Hearing difficulty/problems with background noise	0.3	0.5	1.5	-0.1	-0.2	-0.7	0.5	-1.2	-0.7	-0.2	-1.0	-1.0	-1.1	-0.7	-0.0	-0.3	-0.3	-0.0	0.1	1.0	-0.7
Hair/balding pattern: Pattern 2	0.3	0.4	1.4	-0.7	-1.0	-0.2	0.1	0.7	-0.6	-0.7	0.3	0.3	-0.7	-1.2	0.4	0.2	-0.3	-0.3	-0.8	0.3	-0.7
Medication: Simvastatin	0.3	0.4	1.8	-1.0	1.2	-0.4	-0.3	-0.4	-0.4	-1.0	-0.2	0.2	0.4	-0.0	-0.5	-0.2	-0.9	-1.3	0.1	-0.2	-0.1
Time employed in main current job	0.3	0.3	1.3	-0.1	0.9	0.3	0.8	0.4	0.1	-0.1	1.0	0.3	0.1	0.0	-0.4	0.8	0.1	-0.7	-0.2	-1.1	0.0
Happiness	0.3	0.4	1.4	-0.7	0.4	-0.2	-0.3	0.6	-0.1	-0.5	0.9	-0.6	0.4	-0.4	0.0	0.4	-1.2	-0.4	-1.2	0.6	-0.4
Medication: Cholesterol lowering	0.3	0.4	1.6	-0.5	1.2	-0.3	-0.5	-0.7	-0.3	-0.6	-0.3	1.0	1.1	0.4	-0.1	-0.1	-0.5	-1.3	0.5	-0.8	0.3
Lung cancer (father)	0.3	0.3	2.8	-0.1	-0.2	-0.1	1.7	-0.4	-0.6	-0.0	-0.4	0.2	-1.0	-0.2	-0.2	-0.5	-0.2	0.2	0.1	-0.9	-0.0
Impedance of arm (left)	0.3	1.6	4.8	-0.7	-2.2	-1.0	-0.1	-2.2	-1.4	-0.9	-1.6	-0.4	-1.6	-1.2	-0.5	-1.7	0.1	0.6	-0.8	-1.4	-0.9
Peak expiratory flow (PEF)	0.3	0.8	4.0	0.5	0.3	-0.0	2.0	-1.1	0.4	0.4	-1.8	-0.4	-1.4	0.6	0.7	-0.0	1.2	0.7	0.5	-0.2	0.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.7	-0.3	-0.1	-0.0	0.9	0.3	0.3	-0.3	0.5	-0.6	1.0	0.3	-1.2	-0.1	-0.8	-1.3	-1.3	-0.2	0.2
Leg fat mass (right)	0.3	1.2	4.9	-1.1	0.7	-0.7	1.3	-1.6	-0.6	-1.1	-0.7	-0.2	-2.2	-1.4	1.1	0.9	0.1	0.2	-0.6	1.0	-1.7
Diabetes diagnosed by doctor	0.3	0.5	2.4	0.2	1.3	0.3	-1.5	0.1	0.7	0.1	1.1	-0.1	1.0	0.2	-0.0	0.7	0.5	-0.4	0.7	0.4	0.1
Eye problems/disorders: Cataract	0.3	0.3	1.3	-0.7	-0.6	-0.4	-0.2	-0.4	-0.3	-0.7	-0.5	-0.8	-1.1	-0.7	-0.4	0.2	-0.2	-0.3	-0.6	-0.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	2.1	-0.7	-0.0	-0.3	-0.2	0.3	-0.4	-0.7	-0.4	-0.6	0.4	-0.0	-1.4	-0.6	-0.5	-0.7	-0.7	-0.8	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	2.3	-0.2	-0.5	0.5	-1.5	0.5	0.1	-0.0	0.3	0.9	0.8	0.1	-0.3	-0.1	-0.8	-0.5	0.1	-0.6	0.5
Leg fat mass (left)	0.3	1.3	4.4	-1.3	0.7	-0.9	1.4	-1.5	-0.8	-1.3	-0.8	-0.4	-2.1	-1.6	0.7	0.6	-0.1	-0.2	-0.8	0.8	-1.9
Depression (Nagel 2018)	0.2	0.3	1.1	-0.6	-0.3	-0.4	-0.2	-0.6	0.2	-0.6	-0.6	-0.1	0.4	-0.4	0.2	0.7	-0.4	-0.8	-1.0	0.8	-0.6
HDL Cholesterol	0.2	0.3	1.1	0.6	0.6	0.3	0.4	0.6	0.7	0.5	0.9	0.4	0.5	0.6	-0.1	0.5	0.6	-0.7	0.1	1.0	0.1
Rheumatoid Arthritis	0.2	0.3	0.9	0.6	0.1	0.2	-0.3	0.7	0.6	0.6	0.7	0.0	0.9	0.4	0.1	1.0	0.1	0.2	0.4	0.7	0.3
Blood Red Count	0.2	2.1	13.2	0.5	3.6	0.8	-1.3	1.9	0.3	0.6	2.3	-0.3	3.0	1.5	-0.1	-0.4	-0.5	-0.3	-0.1	-0.7	0.9
BMI	0.2	1.1	3.0	-1.3	0.6	-1.1	0.3	-1.0	-1.4	-1.2	-0.7	-1.1	-1.4	-1.7	0.3	-0.1	-0.6	0.2	-0.8	1.0	-1.7
Hypothyroidism (self reported)	0.2	0.3	2.2	0.5	-0.2	-0.3	-0.3	-0.4	0.6	0.4	0.0	1.4	0.2	-0.3	1.5	0.7	0.6	-0.0	0.1	-0.0	-0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	3.0	-0.7	1.1	0.0	-1.7	-0.0	0.2	-0.7	0.8	-0.2	0.3	-0.3	-0.3	0.3	-0.5	-1.0	-0.3	0.3	-0.3
Lung FEV1/FVC ratio	0.2	1.1	5.5	0.8	0.3	0.7	-2.3	-0.4	1.0	0.6	-0.3	-1.7	1.4	0.8	1.1	0.5	0.9	0.4	0.5	1.8	0.4
Vitamin and mineral supplements	0.2	0.3	1.6	0.1	1.1	0.1	-0.2	0.1	-0.2	-0.1	0.2	-0.1	0.2	0.1	1.2	0.2	0.4	0.3	-0.4	1.3	-0.4
Hand grip strength (right)	0.2	0.6	2.1	-0.2	1.2	-0.1	1.4	1.4	-0.2	-0.1	-0.5	1.0	0.4	0.8	-0.8	-1.0	-0.3	-0.9	-0.0	-0.9	0.5
Age when periods started (menarche)	0.2	0.6	2.8	0.1	0.9	-1.0	-0.1	-0.1	-0.6	0.1	-1.2	-0.9	-0.4	-0.1	-1.5	-1.7	0.1	-0.1	0.4	0.2	-0.4
Body mass index (BMI)	0.2	0.8	2.3	-1.1	0.8	-0.9	0.5	-1.0	-1.0	-1.0	-0.3	-1.0	-1.1	-1.5	0.6	0.5	-0.3	-0.2	-0.8	0.8	-1.5
Pain all over the body in last month	0.2	0.2	0.5	-0.0	0.5	0.2	-0.7	0.2	0.2	-0.1	0.5	0.5	0.1	-0.2	0.7	0.5	0.6	-0.6	-0.4	-0.4	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	1.1	-0.3	0.4	-0.5	-0.6	0.5	0.2	-0.3	-0.3	-1.0	0.7	0.2	-0.9	-0.2	-0.6	-0.4	-0.4	-0.7	0.2
Medication: Lansoprazole	0.2	0.3	1.0	0.2	0.4	-0.2	-0.8	-0.8	-0.2	0.2	0.0	-0.5	-0.0	-0.5	1.0	0.6	-0.1	0.7	-0.6	0.4	-0.4
Prospective memory result	0.2	0.3	1.1	-0.7	0.5	-0.7	-0.1	-1.1	-0.2	-0.7	-0.2	-0.4	-0.2	-0.6	0.5	0.3	-0.5	0.7	0.0	0.2	-0.6
High blood pressure (siblings)	0.2	0.2	1.5	-0.1	0.1	-0.4	-1.2	-0.4	-0.8	-0.2	-0.1	-0.4	-0.4	-0.4	0.3	-0.3	-0.0	-0.5	-0.5	-0.4	-0.7
Leg fat percentage (right)	0.2	0.9	3.1	-0.5	0.3	-0.2	0.6	-1.6	-0.7	-0.5	-0.3	0.2	-1.7	-1.2	1.8	1.0	0.6	1.1	0.1	0.8	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.4	-0.4	-0.4	-0.1	-0.0	-0.6	-0.4	-0.0	-0.3	-0.5	-0.6	-0.6	-0.6	-0.8	-0.6	-0.2	0.7	-0.7
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	-0.3	-0.9	-1.1	0.6	-0.1	-0.8	-0.2	-0.3	-0.6	-0.8	-0.9	-0.6	-0.9	-0.3	0.3	0.3	0.1	-0.5
Mean time to correctly identify matches	0.2	0.4	3.4	-0.7	-0.3	-0.6	-0.4	-0.1	-0.6	-0.7	0.1	-0.3	0.2	-0.3	-1.3	-0.5	-0.5	-0.5	-0.1	-1.8	-0.2
Chest pain or discomfort	0.2	0.3	0.9	0.3	-0.4	0.8	-0.0	0.0	0.8	0.2	0.7	-0.1	1.0	0.7	0.1	0.8	-0.5	-0.6	-0.8	0.7	0.5
Age at last live birth	0.2	0.3	1.7	-0.2	0.1	-0.3	-0.9	-0.8	-0.0	-0.2	-1.3	0.5	-0.5	0.2	-0.3	-0.5	-0.0	-0.1	0.1	-1.1	0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.3	-0.5	0.5	0.1	0.7	-0.1	0.5	0.6	0.8	-0.8	-0.3	0.1	0.8	-0.2	0.4	0.7	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	2.3	-0.1	0.7	0.1	1.5	0.6	0.9	-0.0	-0.6	0.2	-0.2	0.7	-0.1	0.5	0.2	-0.5	-0.4	1.5	-0.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	1.1	-0.6	1.0	-0.3	-0.0	-0.4	-0.9	-0.6	-0.2	0.3	-0.6	-0.2	0.3	-0.7	0.2	0.0	-0.2	-0.1	-0.6
Friendships satisfaction	0.2	0.2	1.1	-0.6	-0.2	-0.3	-0.1	-0.1	-0.1	-0.5	0.4	0.0	0.2	-0.4	-0.5	0.4	-1.0	-0.2	-0.8	-0.6	-0.2
Asthma (self-reported)	0.2	0.3	1.0	-0.1	-0.0	-0.6	-0.8	-0.8	-0.4	-0.2	-0.4	-1.0	-0.3	-0.5	0.2	-0.5	0.2	-0.7	-0.9	0.4	-0.7
Wears glasses or contact lenses	0.2	0.3	1.4	0.1	0.2	-0.3	0.5	0.4	0.3	0.0	0.6	-1.2	0.2	-0.6	-0.3	0.5	0.5	-0.8	-0.3	0.8	-0.6
Medication: Lisinopril	0.2	0.2	0.9	0.2	0.3	-0.1	0.2	0.5	-0.2	0.1	0.6	-1.0	0.3	-0.1	-0.9	-0.4	0.1	-1.0	-0.2	0.4	-0.3
Leg fat percentage (left)	0.2	0.8	2.5	-0.6	0.2	-0.4	0.7	-1.5	-1.0	-0.6	-0.4	-0.0	-1.6	-1.3	1.3	0.6	0.5	0.9	0.1	0.3	-1.2
Unable to work because of sickness or disability	0.2	0.3	1.4	-0.6	0.7	0.1	-1.2	0.5	-0.0	-0.5	0.5	0.2	1.0	0.1	-0.6	0.4	-0.5	-0.7	-0.2	0.0	0.0
Impedance of whole body	0.2	1.2	4.8	-0.3	-2.2	-0.5	0.2	-1.7	-1.2	-0.5	-1.4	0.2	-1.4	-0.8	-0.4	-1.4	0.4	1.0	-0.1	-1.6	-0.4
Respiratory disease	0.1	0.3	1.2	0.6	-0.2	0.4	-0.1	0.8	0.6	0.6	1.1	0.6	0.4	-0.0	0.3	0.5	0.3	-0.5	-0.3	0.7	0.1
Tanning	0.1	1.0	3.9	0.3	-0.1	0.8	0.3	1.9	0.3	0.6	0.2	2.0	1.5	1.0	-1.1	-0.2	-1.0	-0.2	1.3	0.2	1.3
Impedance of leg (right)	0.1	0.5	2.0	0.3	-1.2	0.6	0.3	-0.9	-0.2	0.2	-0.5	1.4	-0.8	0.1	0.5	-0.2	0.7	1.3	0.8	-0.9	0.4
Maternal smoking around birth	0.1	0.2	0.8	0.4	-0.5	0.3	0.3	0.6	0.1	0.4	0.4	0.7	0.4	0.1	-0.2	0.1	-0.3	-0.0	0.9	0.4	0.5
Relative age voice broke	0.1	0.2	0.8	0.2	0.2	0.3	-0.9	0.0	0.6	0.2	-0.5	-0.3	0.7	0.7	-0.5	0.5	-0.2	0.5	0.1	-0.3	0.6
Multivitamins +/- minerals	0.1	0.1	0.3	0.4	0.2	0.3	-0.1	0.2	0.4	0.5	0.3	-0.3	0.0	0.2	-0.6	-0.3	0.3	0.1	0.2	0.1	0.1
Impedance of leg (left)	0.1	0.6	2.3	0.2	-1.2	0.4	0.4	-0.7	-0.5	0.2	-0.6	1.1	-0.6	0.1	-0.1	-0.7	0.7	1.1	0.8	-1.5	0.4
Had menopause	0.1	0.1	0.7	0.2	-0.1	-0.0	-0.1	0.1	0.1	0.1	0.1	0.3	-0.1	0.0	-0.0	-0.1	-0.2	-0.8	-0.2	0.6	-0.2
Asthma	0.1	0.2	0.9	0.3	0.3	-0.3	-1.0	-0.4	-0.1	0.2	-0.1	-0.7	0.1	-0.1	0.4	-0.4	0.3	-0.5	-0.5	0.4	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.5	-0.3	0.1	-0.3	-0.4	0.1	-0.6	-0.2	-0.5	-0.7	0.3	-0.2	0.3	-0.4	-0.4	-0.3	-0.2	0.5	-0.2
Number of full sisters	0.1	0.2	1.0	0.0	0.3	-0.0	-0.2	-0.5	-0.1	-0.1	-0.7	-0.2	0.5	0.4	0.2	-0.3	-0.6	-0.2	-0.2	-1.0	0.4
Irritability	0.1	0.2	0.7	-0.8	0.3	-0.1	0.3	-0.1	0.3	-0.8	-0.1	-0.7	-0.3	-0.1	0.0	0.6	-0.1	-0.5	-0.6	-0.3	0.0
Age started oral contraceptive pill	0.1	0.1	0.4	-0.5	0.4	-0.3	-0.6	-0.1	-0.0	-0.5	0.5	0.1	-0.1	-0.2	-0.0	-0.3	-0.2	-0.6	-0.1	-0.5	-0.3
Commuting to job workplace: Cycle	0.1	0.1	0.6	0.2	0.6	0.1	0.3	0.6	0.3	0.1	-0.6	0.1	0.4	0.4	0.0	-0.0	0.2	0.1	-0.2	0.8	0.2
Hair Pigment	0.0	0.5	3.3	-0.4	-0.8	-0.5	0.3	0.6	-0.1	-0.4	0.4	-0.5	-0.4	-0.8	-0.6	-0.6	0.5	-0.2	0.5	1.8	-0.9

Hub : Genes

SETDB2

Models

Trait associations