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chr14:50,199,169-51,830,366

Best TWAS P=5.23e-18 · Best GWAS P=1.17e-21 conditioned to 0.0132

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SAV1	0.09	0.03	blup	478	0.07	2.1e-08	5.0	6.1	1.4e-09	-0.69	0.50	0.50	FALSE
2	GTEx	Brain Cerebellar Hemisphere	SAV1	0.19	0.06	lasso	7	0.02	1.3e-01	5.2	5.4	5.2e-08	-0.66	0.10	0.31	FALSE
3	GTEx	Cells Transformed fibroblasts	MAP4K5	0.16	0.08	lasso	4	0.08	1.6e-06	9.0	7.6	3.0e-14	-0.85	0.06	0.94	FALSE
4	GTEx	Esophagus Mucosa	SAV1	0.13	0.15	enet	14	0.15	5.1e-10	5.1	5.2	1.7e-07	-0.70	0.99	0.01	FALSE
5	GTEx	Heart Atrial Appendage	SAV1	0.12	0.00	enet	18	0.00	2.1e-01	2.7	5.9	4.3e-09	-0.53	0.06	0.27	FALSE
6	GTEx	Liver	RP11-248J18.2	0.32	-0.01	enet	5	-0.01	7.0e-01	-4.8	-5.4	5.9e-08	0.41	0.04	0.41	FALSE
7	GTEx	Nerve Tibial	SAV1	0.08	0.04	lasso	2	0.04	9.1e-04	6.0	-8.4	3.2e-17	0.76	0.04	0.88	TRUE
8	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SAV1	0.07	0.05	enet	6	0.07	1.1e-06	5.0	5.5	3.2e-08	-0.69	0.88	0.12	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDKL1	0.04	0.01	blup	78	0.03	1.1e-07	-3.5	5.2	1.5e-07	-0.27	0.13	0.76	FALSE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	MAP4K5	0.03	0.02	lasso	3	0.02	8.0e-05	9.0	8.7	5.2e-18	-0.84	0.00	0.99	TRUE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	SAV1	0.02	0.01	lasso	2	0.02	1.5e-04	-9.5	7.7	1.8e-14	-0.94	0.01	0.98	FALSE
12	The Cancer Genome Atlas	Glioblastoma Multiforme	SAV1	0.10	0.02	blup	48	0.05	1.6e-02	-5.4	8.1	5.5e-16	-0.92	0.02	0.38	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	SAV1	0.07	0.02	enet	8	0.04	2.3e-05	-5.6	6.8	1.2e-11	-0.82	0.01	0.98	FALSE
14	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SAV1	0.26	0.08	lasso	1	0.07	5.6e-04	5.4	-5.4	7.8e-08	0.41	0.02	0.13	FALSE
15	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CDKL1	0.12	0.06	enet	6	0.05	3.2e-03	4.2	5.2	2.2e-07	-0.30	0.07	0.10	FALSE
16	The Cancer Genome Atlas	Stomach Adenocarcinoma	SAV1	0.03	0.02	blup	48	0.02	2.2e-02	-6.9	7.4	1.4e-13	-0.88	0.04	0.36	FALSE