TWAS hub - MAP4K5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1610	0.0450	1.2e-06	0.079	NA	0.076	NA	0.079	1.5e-06	NA	2.4e-06	NA	1.6e-06
2	YFS	Blood	0.0137	0.0079	2.9e-02	0.012	-0.001	0.004	0	0.003	6.7e-05	0.82000	1.3e-02	0.31	2.6e-02
3	TCGA	Breast Invasive Carcinoma	0.0265	0.0133	2.6e-03	0.021	0.013	0.014	NA	0.019	2.5e-05	0.00085	4.6e-04	NA	8.0e-05
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0370	0.0185	6.8e-04	0.010	0.026	0.021	NA	0.021	2.3e-02	0.00055	1.8e-03	NA	1.6e-03
5	TCGA	Lung Squamous Cell Carcinoma	0.0709	0.0287	2.7e-04	0.003	0.022	0.014	NA	0.013	1.5e-01	0.00130	8.3e-03	NA	1.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Smoking status: Previous	4.8	7.2	14.8	-3.9	-0.7	-3.6	-2.7	0.3
Hypertension (Self-reported)	4.7	13.1	22.2	4.7	1.2	4.4	3.4	3.4
Vascular/heart problems diagnosed by doctor	4.6	12.5	20.8	-4.6	-1.7	-4.3	-3.1	-3.2
Ever had stillbirth, spontaneous miscarriage or termination	4.5	4.8	8.4	2.3	2.9	2.0	2.4	0.9
Cardiovascular Disease	4.4	14.4	22.6	4.8	0.9	4.7	2.3	4.6
Myopia	4.3	6.2	9.9	2.9	1.3	2.2	3.2	2.4
Medication: Blood pressure	4.2	7.9	13.0	3.6	0.9	3.1	3.1	2.6
High blood pressure	4.1	11.3	18.9	4.3	1.5	4.0	3.0	3.2
Medication: Amlodipine	4.1	5.7	9.3	2.8	-0.1	2.5	2.3	3.1
Medication: Atorvastatin	3.6	4.4	6.8	2.6	2.1	2.0	2.1	1.5
Mean Putamen Volume	3.5	4.0	5.7	2.1	-1.6	2.4	1.4	2.3
Diabetes (father)	3.5	4.3	8.2	2.9	-0.1	2.8	1.8	1.6
Alzheimer’s Disease (including proxy)	3.2	4.7	17.4	0.3	-4.2	-0.0	0.7	2.3
Mouth/teeth dental problems: Dentures	3.2	5.4	9.1	2.3	-1.2	2.0	2.7	3.0
Alzheimer’s Disease (in father)	3.0	3.3	5.7	1.5	-1.6	0.5	2.4	2.4
Blood Platelet Count	3.0	34.2	74.8	7.6	0.7	8.7	3.8	4.9
Systolic Blood Pressure	3.0	15.2	30.7	5.5	0.7	5.1	2.3	3.7
Qualifications: College or University degree	3.0	9.5	26.0	-2.3	2.6	-2.1	-2.3	-5.1
Illnesses of father: High blood pressure	3.0	3.7	7.7	2.7	1.7	2.8	0.6	-0.2
Lung FEV1/FVC ratio	2.9	14.6	23.6	4.1	-2.8	4.2	2.8	4.9
Qualifications: A levels/AS levels or equivalent	2.9	6.3	25.7	-0.4	2.2	-0.4	-0.8	-5.1
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	11.0	-3.0	-1.0	-3.3	-1.1	-1.5
Medication: Blood pressure	2.8	4.9	10.6	2.9	0.6	3.3	1.0	2.1
Leg fat percentage (right)	2.6	9.5	32.6	2.2	-0.9	2.5	1.6	5.7
Medication: Bendroflumethiazide	2.6	3.9	6.7	2.3	0.6	2.0	1.8	2.6
Chronic bronchitis/emphysema (father)	2.4	2.8	4.8	-2.2	-1.4	-1.8	-1.8	-0.9
Time employed in main current job	2.4	2.7	6.0	2.0	-1.5	2.4	0.6	1.1
Birth weight	2.4	5.1	14.8	-1.8	1.7	-1.0	-2.0	-3.8
High cholesterol (Self-reported)	2.4	4.2	9.5	2.8	1.3	3.1	1.1	0.7
Had other major operations	2.3	2.8	8.0	1.3	0.7	0.4	2.8	1.9
Relative age of first facial hair	2.2	4.5	9.4	-1.8	2.6	-1.7	-0.5	-3.1
Hearing difficulty/problems with background noise	2.2	3.5	5.0	-1.5	1.8	-2.2	-1.4	-2.1
Age at first live birth	2.2	3.9	7.2	-2.5	1.2	-2.7	-1.5	-1.6
Leg fat percentage (left)	2.2	8.1	29.2	1.9	-0.4	2.1	1.8	5.4
Relative age voice broke	2.1	3.2	4.3	-2.1	1.6	-1.8	-2.0	-1.3
Age at last live birth	2.0	2.9	6.5	-2.3	-0.5	-2.5	-1.4	-0.6
Systolic blood pressure, automated reading	1.9	5.6	10.4	3.2	0.7	2.9	1.2	2.7
Exposure to tobacco smoke at home	1.9	2.1	6.0	0.2	-2.4	-0.4	1.1	1.7
Ever highly irritable/argumentative for 2 days	1.9	2.3	3.8	1.9	1.1	2.0	1.4	0.8
Body fat percentage	1.9	7.5	25.7	1.7	0.3	1.8	2.4	5.1
Medication for cholesterol	1.9	2.9	4.3	-2.1	-0.1	-1.8	-1.7	-2.0
Illnesses of father: None of the above (group 1)	1.9	2.3	5.6	-2.2	-0.2	-2.4	-0.6	1.0
Stomach or abdominal pain in last month	1.8	2.2	4.1	2.0	0.9	2.0	1.0	1.1
Medication: Atenolol	1.8	2.2	5.1	2.0	-0.2	2.3	1.3	0.4
Past tobacco smoking	1.8	3.4	7.8	2.6	-0.3	2.8	1.3	-0.6
Alzheimer’s Disease (in mother)	1.7	2.0	8.9	-0.2	-3.0	-0.3	-0.0	0.9
High blood pressure (mother)	1.7	2.4	9.1	1.0	3.0	0.3	1.3	0.1
Worrier / anxious feelings	1.7	3.3	4.5	-2.0	1.3	-2.1	-1.5	-2.0
Medication: Lansoprazole	1.7	1.9	4.2	-1.4	2.1	-0.7	-1.2	-1.2
Illnesses of siblings: Diabetes	1.7	2.1	5.7	1.7	1.0	0.7	2.4	0.7
Wears glasses or contact lenses	1.7	1.9	4.2	0.7	1.9	0.8	0.8	-2.0
Prostate Cancer	1.6	2.2	5.8	1.6	0.4	1.0	2.4	1.2
Pack years adult smoking proportion	1.6	2.4	7.3	0.2	-2.0	0.6	0.1	2.7
Sitting height	1.6	11.6	15.2	-3.8	-2.6	-2.8	-3.9	-3.8
Medication: Aspirin	1.6	2.0	5.2	1.9	1.2	2.3	0.1	0.1
Arm fat percentage (left)	1.6	6.4	20.0	1.8	0.6	1.7	2.4	4.5
Pack years of smoking	1.6	2.4	6.7	0.5	-2.0	0.8	0.5	2.6
Schizophrenia (2014)	1.5	3.2	6.1	2.0	0.5	2.4	-0.4	2.5
Arm fat percentage (right)	1.5	6.0	19.4	1.6	0.4	1.6	2.3	4.4
Peak expiratory flow (PEF)	1.5	3.6	5.6	2.3	-0.0	2.1	2.4	1.6
Neck or shoulder pain in last month	1.5	2.1	4.8	1.2	2.2	1.3	1.4	0.6
Chest pain or discomfort	1.5	2.1	3.2	1.8	1.7	1.6	1.4	0.3
Medication: Aspirin	1.5	2.0	5.8	1.8	1.1	2.4	-0.0	0.1
Primary Biliary Cirrhosis	1.4	1.9	8.4	0.6	-0.5	0.2	0.8	2.9
Qualifications: None of the above	1.4	3.0	11.3	-0.7	-1.4	-1.0	0.2	3.4
Mouth/teeth dental problems	1.4	2.2	3.2	-1.6	-0.8	-1.1	-1.8	-1.8
Alcohol intake versus 10 years previously	1.4	2.1	4.0	-2.0	-1.2	-1.8	-0.9	1.2
Leg fat mass (right)	1.4	5.3	20.7	1.2	-1.0	1.5	1.1	4.6
Coronary Artery Disease (CAD)	1.3	1.5	3.3	1.3	-1.6	1.8	-0.1	0.2
Ever had hysterectomy (womb removed)	1.3	1.5	3.3	-0.7	1.6	-0.6	-1.8	-0.9
Age when periods started (menarche)	1.3	3.0	12.4	-0.1	1.3	0.2	-1.1	-3.5
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	6.7	-1.2	0.8	-0.9	-2.2	-2.6
Mouth/teeth dental problems: Loose teeth	1.3	1.6	4.4	0.9	2.1	0.7	1.5	0.2
Overall health rating	1.3	2.8	4.4	1.8	1.2	1.2	1.9	2.1
Hearing aid user	1.3	1.5	3.3	-1.8	0.5	-1.4	-1.3	-0.3
Medication: Lisinopril	1.3	1.6	2.6	1.6	-0.6	1.4	1.2	1.3
Supplements: Zinc	1.2	1.3	2.7	-1.2	0.6	-1.6	-0.4	-1.4
Trunk fat percentage	1.2	4.9	16.5	1.1	0.8	1.1	2.3	4.1
Average weekly fortified wine intake	1.2	1.4	4.5	0.2	2.1	0.5	0.4	-1.5
Waist circumference	1.2	4.4	17.6	0.9	-0.7	1.2	1.3	4.2
Lung cancer (father)	1.2	1.4	3.2	-1.0	-0.5	-1.4	0.7	1.8
Birth weight of first child	1.2	2.1	7.0	0.6	0.9	1.1	-1.0	-2.7
Number of full sisters	1.2	1.4	2.2	-1.5	1.3	-1.1	-1.4	-0.1
Had major operations	1.2	1.5	3.8	-0.7	1.9	-1.4	0.9	-0.3
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.0	-1.4	-1.4	-1.4	-1.1	-0.7
Ever smoked	1.2	2.1	4.1	-1.6	1.9	-2.0	-0.2	-0.0
Cholesterol lowering medication	1.2	1.7	3.6	1.6	1.9	1.4	0.5	0.5
Basal cell carcinoma (self-reported)	1.2	1.4	3.2	-0.5	1.6	-0.9	0.4	-1.8
Leg fat mass (left)	1.2	4.9	19.5	1.0	-0.7	1.3	1.2	4.4
Schizophrenia (2018)	1.1	2.4	5.4	1.7	0.2	1.8	0.2	2.3
Body Mass Index (BMI) (2010)	1.1	1.5	6.2	-0.3	-1.0	-0.2	0.2	2.5
Lupus	1.1	1.7	3.5	-1.0	1.7	-1.0	0.2	-1.9
Ever used hormone-replacement therapy (HRT)	1.1	1.4	5.7	-1.0	-0.2	-0.4	-2.4	-0.5
Medication: Metformin	1.1	1.5	2.6	1.2	-1.2	1.3	0.7	1.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.9	1.5	-0.1	2.0	-0.7	0.5
Illnesses of siblings	1.1	1.6	3.3	-1.0	-1.3	-0.5	-1.8	1.3
Pulse rate	1.1	1.8	3.3	1.7	-0.7	1.5	0.5	1.8
Hair/balding pattern: Pattern 4	1.1	2.7	6.6	-1.3	-2.3	-0.1	-2.6	0.3
Number of children fathered	1.1	1.3	3.6	-1.2	-1.9	-0.7	-0.9	-0.0
Migraine (self-reported)	1.1	1.3	2.6	-1.5	-1.1	-1.6	-0.3	0.8
Mean time to correctly identify matches	1.1	2.2	4.8	1.4	-0.2	1.0	1.8	2.2
Commuting to job workplace: Car/motor vehicle	1.1	1.3	4.7	0.5	-0.6	-0.0	1.0	2.2
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.2	1.4	1.5	1.3	0.6	-0.5
Number of self-reported non-cancer illnesses	1.1	2.0	3.6	1.7	0.5	1.3	1.9	1.1
Fractured/broken bones in last 5 years	1.1	1.5	2.2	1.5	0.6	1.2	1.1	1.5
Age started oral contraceptive pill	1.1	1.4	2.6	0.8	1.3	1.4	0.2	-1.6
Diastolic blood pressure, automated reading	1.1	3.5	8.6	2.2	-0.0	1.8	0.8	2.9
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.2	-1.3	1.5	-0.6	-1.4	-1.1
Schizophrenia vs Biploar Disorder	1.0	1.3	3.6	1.6	0.1	1.9	0.1	0.5
Rheumatoid Arthritis	1.0	1.4	3.0	-1.6	1.0	-1.7	-0.5	0.1
Blood Red Count	1.0	9.4	27.4	0.1	4.0	0.4	-1.9	-5.2
Number of treatments/medications taken	1.0	1.9	3.5	1.3	1.9	0.8	1.6	0.9
Diabetes (mother)	1.0	1.3	5.0	-0.6	-0.8	0.2	-0.6	2.2
Townsend deprivation index at recruitment	1.0	1.4	3.1	0.8	1.8	0.0	1.7	0.6
Current tobacco smoking	1.0	1.6	2.7	1.6	-0.5	1.5	1.4	1.0
Financial difficulties in last 2 years	1.0	1.4	2.3	1.4	0.9	0.9	1.5	1.1
Medication: Ramipril	1.0	1.2	4.3	0.7	2.1	0.2	0.2	1.1
Blood clot in the leg (DVT)	1.0	1.4	2.0	-1.4	1.2	-0.7	-1.4	-1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.2	-1.5	-0.0	-1.4	-0.6	-1.4
Whole body fat mass	1.0	4.2	17.1	0.8	-0.3	1.0	1.4	4.1
Loneliness, isolation	1.0	1.4	4.0	1.0	0.9	0.4	2.0	1.1
Mother’s age at death	1.0	1.3	3.0	-1.6	0.6	-1.7	-0.5	-0.4
Bipolar Disorder or Schizophrenia	0.9	2.2	8.0	1.1	0.4	1.2	-0.4	2.8
Fasting Glucose	0.9	1.0	3.6	0.1	-1.9	1.1	-0.4	-0.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.8	1.0	-1.3	1.2	0.4	0.8
Angina	0.9	1.2	1.9	1.0	-0.9	1.1	1.4	1.1
Body mass index (BMI)	0.9	4.0	16.4	0.9	-0.6	1.0	1.2	4.0
Pain all over the body in last month	0.9	0.9	4.2	-0.3	0.1	0.5	-2.1	0.0
Impedance of arm (right)	0.9	4.3	11.7	1.1	3.4	0.3	2.4	-1.6
Length of working week for main job	0.9	1.0	3.1	0.1	-0.5	-0.4	1.2	1.7
Gout (self-reported)	0.9	1.2	2.4	1.1	0.5	0.4	1.5	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.0	-1.6	-0.8	-1.4	-2.0	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.0	-1.4	-0.1	-1.1	-0.9	-1.1
Alcohol drinker status: Never	0.9	1.1	1.7	0.5	-1.3	1.0	-0.8	1.3
Average weekly beer plus cider intake	0.9	1.3	2.3	-1.5	-0.2	-1.1	-1.1	1.1
Ever depressed for a whole week	0.9	1.1	2.6	1.6	0.5	1.6	-0.2	0.4
Intelligence (Savage-Jansen 2018)	0.8	2.5	6.0	-1.6	0.0	-1.7	-1.0	-2.5
Heel T-Score	0.8	6.4	22.7	-2.0	0.0	-0.9	-4.8	-2.1
BMI	0.8	4.9	19.3	1.1	-1.0	1.5	0.7	4.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.3	-1.0	1.2	-0.8	-1.5	-0.3
Severe depression (siblings)	0.8	0.9	2.2	-0.7	0.6	0.2	-1.5	-1.1
Taking other prescription medications	0.8	1.3	4.1	0.1	2.0	-0.5	1.4	0.3
Trunk fat mass	0.8	3.3	13.4	0.6	0.1	0.8	1.5	3.7
Happiness	0.8	1.0	2.4	1.0	0.3	0.8	0.8	1.6
Impedance of arm (left)	0.8	3.7	11.1	0.9	3.3	0.2	2.2	-1.2
Arm fat mass (right)	0.8	3.3	13.8	0.7	-0.2	0.9	1.2	3.7
Standing height	0.8	7.8	12.9	-3.6	-0.8	-2.7	-2.7	-3.2
High blood pressure (siblings)	0.8	1.2	2.4	1.5	1.0	1.1	1.2	-0.2
Pulse wave peak to peak time	0.8	0.9	4.1	-0.2	-0.2	-0.1	-0.6	-2.0
Diabetes diagnosed by doctor	0.8	1.3	3.0	1.1	-1.7	1.3	0.5	0.5
Smoking status: Current	0.8	1.3	2.4	1.6	-0.2	1.3	1.4	0.8
Arm fat mass (left)	0.8	3.1	13.2	0.6	-0.1	0.9	1.1	3.6
Neuroticism (Nagel 2018)	0.7	1.7	2.6	-1.3	1.4	-1.4	-1.6	-0.8
LDL Cholesterol	0.7	1.2	2.8	0.9	1.1	0.9	0.4	1.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.5	-0.6	-0.6	-0.1	-1.6	1.0
Height	0.7	13.4	22.2	-4.5	-1.4	-3.1	-3.7	-4.7
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.9	-1.2	0.5	-0.9	-1.7	-1.7
Trunk fat-free mass	0.7	4.1	6.9	-2.5	-1.9	-1.7	-2.6	-0.8
Number of live births	0.7	1.0	3.0	0.7	-1.7	0.6	-0.2	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.9	-0.3	1.7	-0.3	-0.2	-1.1
Medication: Cholesterol lowering	0.7	1.2	2.2	1.2	1.2	1.5	0.0	0.7
Illnesses of mother	0.7	0.9	3.3	-0.7	-1.8	-0.6	-0.2	0.1
Trunk predicted mass	0.7	4.0	6.8	-2.5	-1.8	-1.6	-2.6	-0.9
Arm fat-free mass (right)	0.7	3.4	5.7	-2.2	-2.0	-1.4	-2.4	0.5
Comparative body size at age 10	0.7	1.8	7.0	-0.6	-1.0	-0.5	0.7	2.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.3	-1.0	-0.8	-1.5	0.1	0.6
Angina (self-reported)	0.7	0.9	1.5	0.7	-0.7	1.0	1.2	1.1
Pulse rate, automated reading	0.7	2.4	7.3	0.4	-2.1	0.2	-0.2	2.7
Knee pain experienced in last month	0.7	1.1	3.2	0.6	-1.0	0.7	0.6	1.8
Qualifications: nursing, teaching	0.7	1.1	2.5	0.6	0.7	0.3	1.6	-1.5
Mineral and other dietary supplements	0.7	0.9	1.9	0.9	0.8	1.2	0.2	1.4
Unable to work because of sickness or disability	0.7	1.0	1.9	-1.2	-0.3	-1.1	-1.4	0.5
Commuting to job workplace: Cycle	0.7	0.8	2.3	0.2	-1.2	0.6	-0.3	-1.5
Heart disease (siblings)	0.7	0.9	1.7	0.8	1.3	0.3	1.3	-0.4
Depression (Nagel 2018)	0.6	0.9	2.6	-0.9	1.0	-0.5	-1.6	-0.3
Neuroticism (2016)	0.6	0.8	1.3	-1.0	0.8	-0.8	-1.1	0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.5	0.7	-1.9	0.9	-0.1	0.9
Hand grip strength (left)	0.6	1.5	5.6	-0.7	-1.0	-0.1	-2.4	-0.4
Medication: Co-codamol	0.6	0.7	1.4	-1.0	0.8	-1.2	-0.3	-0.6
Medication: Simvastatin	0.6	0.8	1.7	1.0	0.9	1.3	-0.3	0.7
Fluid intelligence score	0.6	1.3	3.7	-0.6	-0.0	-0.2	-1.5	-1.9
Hip circumference	0.6	2.8	12.3	0.3	-0.1	0.3	1.2	3.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.8	-0.4	1.2	-0.4	0.4	-1.3
Asthma	0.6	1.1	2.3	0.6	1.4	0.2	1.5	-0.8
Pulse wave Arterial Stiffness index	0.6	0.7	3.2	-0.1	0.1	-0.1	0.4	1.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.4	1.2	1.0	0.8	0.4	-0.8
Health satisfaction	0.6	0.8	1.7	1.1	0.1	1.0	0.4	1.3
Eye problems/disorders: None of the above	0.6	0.7	3.0	-0.0	1.7	-0.5	0.3	0.2
Illnesses of father: Heart disease	0.6	0.8	2.0	0.5	0.3	1.1	-0.7	-1.4
Long-standing illness, disability or infirmity	0.6	1.0	1.5	1.2	0.9	0.7	1.2	0.7
Commuting to job workplace: Walk	0.6	0.6	1.4	1.2	0.5	1.0	0.0	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.5	-1.2	1.1	-1.2	-0.6	0.2
Osteoporosis (self-reported)	0.6	0.8	2.4	0.8	-0.3	0.1	1.5	0.9
Financial situation satisfaction	0.6	0.8	2.1	-0.1	0.8	-0.0	-1.0	1.4
Commuting to job workplace: Public transport	0.6	0.7	2.1	0.3	1.4	0.7	-0.5	-0.8
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	1.1	-0.2	0.8	1.2	0.2
Pain experienced in last month	0.6	1.1	2.4	-0.7	-1.3	-0.2	-0.9	-1.5
Bipolar Disorder (2018)	0.5	0.8	2.7	-0.4	0.5	-0.3	-0.8	1.6
Depressed Affect (Nagel 2018)	0.5	1.0	2.8	-1.1	0.1	-0.9	-1.7	-0.0
Worry (Nagel 2018)	0.5	1.0	2.3	-0.5	1.5	-0.4	-0.7	-1.3
Crohns Disease (2017)	0.5	1.2	3.8	-0.3	-0.6	-1.2	0.3	1.9
Bipolar Disorder (2011)	0.5	0.5	2.1	-0.5	-0.1	0.1	-1.5	0.2
Crohns Disease (2012)	0.5	0.9	2.7	-1.0	0.4	-1.7	-0.2	0.7
Average weekly spirits intake	0.5	0.6	0.9	0.5	-1.0	0.8	0.8	0.8
Hand grip strength (right)	0.5	1.3	3.2	-0.6	-1.7	0.1	-1.8	0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.1	-0.6	0.4	-0.2	-1.4	-0.6
Medication: Levothyroxine sodium	0.5	0.9	1.6	0.9	1.3	0.6	1.2	-0.6
Neuroticism score	0.5	1.1	1.9	-0.9	1.4	-1.1	-0.8	-0.8
Depression (self-reported)	0.5	0.5	1.4	0.7	-0.2	0.4	1.2	0.8
Pulse wave reflection index	0.5	0.6	1.9	-0.7	1.4	-0.6	-0.1	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.7	0.4	1.4	-0.3	1.7	-0.1
Worry too long after embarrassment	0.5	0.8	2.2	-0.5	1.5	-1.1	-0.4	-0.4
Shortness of breath walking on level ground	0.5	0.6	2.4	-0.4	-0.0	-0.8	0.1	1.5
Emphysema/chronic bronchitis	0.5	0.6	1.3	-1.2	0.3	-1.1	-0.6	-0.1
Heart disease (mother)	0.5	0.7	2.0	0.1	-0.7	0.6	-1.4	0.6
Arm predicted mass (right)	0.5	2.6	4.5	-1.7	-2.1	-1.0	-2.0	0.6
Alcohol intake frequency.	0.5	1.1	1.8	0.8	-1.1	1.3	-0.7	1.2
Asthma (self-reported)	0.5	1.0	2.7	0.7	1.1	0.3	1.6	-0.6
Whole body water mass	0.5	2.7	4.6	-2.1	-1.7	-1.4	-2.0	-0.4
Average weekly champagne plus white wine intake	0.5	0.7	2.4	0.1	0.5	0.6	-0.8	-1.5
Miserableness	0.5	0.9	2.3	-0.8	0.7	-0.6	-1.5	-0.6
Ever taken oral contraceptive pill	0.5	0.5	1.2	1.1	-0.2	0.5	1.1	-0.2
Eye problems/disorders: Glaucoma	0.5	0.5	1.2	-0.7	-1.1	-0.4	-0.7	-0.6
Arm fat-free mass (left)	0.5	2.5	4.2	-1.9	-1.8	-1.1	-2.1	0.5
Arm predicted mass (left)	0.5	2.7	4.6	-1.9	-2.0	-1.0	-2.1	0.4
Reaction Time	0.4	0.8	2.7	0.5	-0.4	0.3	0.7	1.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.3	-0.8	0.6	-0.9	-0.8	-1.5
Ovarian Cancer	0.4	0.5	1.0	-0.6	0.5	-1.0	0.1	-0.9
Age at First Birth	0.4	0.5	2.0	-0.4	0.5	-0.3	-0.4	-1.4
HbA1C	0.4	0.5	1.4	0.8	-0.0	1.2	-0.4	0.5
Triglycerides	0.4	0.7	1.3	1.0	0.2	1.1	0.1	1.1
Smoking Status	0.4	1.1	1.9	-1.4	-0.9	-1.2	-1.1	-0.3
Hypothyroidism (self reported)	0.4	1.0	2.3	0.7	1.5	0.2	1.4	-0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	0.6	-0.5	0.5	1.3	0.1
Medication for hormone replacement therapy	0.4	0.5	0.9	-0.6	-1.0	-0.2	-0.9	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.4	-0.0	1.6	-0.2	0.0	-0.5
Multivitamins +/- minerals	0.4	0.5	1.0	-0.9	-0.4	-1.0	0.1	0.7
Number of incorrect matches in round	0.4	0.6	1.0	-0.6	-1.0	-0.1	-0.9	1.0
Alcohol usually taken with meals	0.4	0.6	2.0	0.1	0.6	-0.7	0.4	-1.4
Hair/balding pattern: Pattern 2	0.4	0.5	1.5	1.1	-0.1	1.2	0.1	0.2
Diabetes (self-reported)	0.4	0.6	1.8	0.5	-1.3	0.8	-0.2	0.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	0.3	0.2	-0.3	1.2	1.1
Noisy workplace	0.4	0.5	1.0	-0.4	-0.7	-0.2	-0.8	1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	1.0	0.7	1.1	0.3	-0.8
Glaucoma (self-reported)	0.4	0.5	1.4	-0.6	-1.2	-0.3	-0.6	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	0.4	-0.8	0.1	0.6	1.1
Medication for pain relief, constipation, heartburn	0.4	0.7	2.9	-0.6	-1.7	-0.5	-0.3	0.3
Comparative height size at age 10	0.4	2.0	2.8	-1.7	1.4	-1.4	-0.9	-1.6
Supplements: Vitamin C	0.4	0.5	0.9	-0.7	-0.3	-0.3	-1.0	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	0.3	-0.8	1.0	-0.8	-0.2
Whole body fat-free mass	0.4	2.5	4.5	-2.1	-1.6	-1.4	-1.9	-0.5
Mood swings	0.4	0.8	1.4	-0.4	1.2	-0.9	-0.8	-0.8
Ever had bowel cancer screening	0.4	0.5	1.5	0.3	0.4	-0.1	1.2	0.9
Eye problems/disorders: Cataract	0.4	0.5	1.7	-0.4	-0.4	0.3	-1.3	-0.6
Osteoarthritis (self-reported)	0.4	0.6	1.3	0.4	-1.1	0.3	0.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.8	1.4	0.5	0.8	1.3	0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	0.2	0.9	-0.5	1.0	0.6
Number of operations (self-reported)	0.4	0.5	2.0	-0.1	0.6	-0.5	1.4	0.1
Irritability	0.4	0.7	1.8	-1.0	0.3	-1.4	-0.0	0.6
Supplements: Calcium	0.4	0.4	1.4	-0.8	0.2	-1.2	-0.1	0.3
Impedance of whole body	0.4	1.8	6.6	0.8	2.6	0.4	1.2	-0.4
Irritable Bowel Disease (IBD)	0.3	0.8	1.8	-0.5	-0.8	-1.3	-0.2	1.1
Major Depression (MDD)	0.3	0.3	0.8	0.9	-0.4	0.4	0.4	-0.6
Breast Cancer	0.3	0.8	1.5	-0.7	0.9	-1.2	0.4	-1.1
Lung FVC	0.3	1.5	4.5	0.8	2.1	-0.0	1.5	0.2
Vitamin and mineral supplements	0.3	0.3	0.8	0.1	0.9	0.2	-0.5	-0.8
Maternal smoking around birth	0.3	0.4	1.1	-0.3	-1.0	0.3	-0.6	-0.6
Qualifications: CSEs or equivalent	0.3	0.4	1.1	0.4	-0.8	0.3	0.1	-1.0
Weight	0.3	1.4	5.7	-0.6	-0.9	-0.0	-0.1	2.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	0.4	1.4	0.2	0.2	0.4
Falls in the last year	0.3	0.4	1.4	0.3	0.6	-0.1	1.2	-0.6
Prospective memory result	0.3	0.3	0.9	-0.6	0.9	-0.4	-0.4	-0.4
Breastfed as a baby	0.3	0.3	1.5	0.1	1.2	0.1	0.3	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.8	-0.1	1.3	-0.4	-0.0	-0.2
Medication: Paracetamol	0.3	0.4	1.0	-0.8	0.7	-1.0	-0.0	-0.0
Exposure to tobacco smoke outside home	0.3	0.4	0.6	0.7	0.6	0.4	0.6	0.8
Wheeze or whistling in the chest in last year	0.3	0.6	1.3	0.9	0.8	0.1	1.2	0.3
Leg pain on walking	0.3	0.3	0.8	-0.6	-0.5	-0.9	-0.5	0.2
Back pain experienced in last month	0.3	0.5	1.5	-0.2	1.2	-0.6	0.5	0.4
Guilty feelings	0.3	0.5	1.0	0.3	1.0	-0.2	0.9	-0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	-0.5	0.6	-0.6	-0.1	1.1
Basal metabolic rate	0.3	1.8	3.1	-1.8	-1.5	-1.1	-1.5	0.4
Risk taking	0.3	0.5	0.8	-0.8	0.1	-0.9	0.3	0.9
Ulcerative Colitis (UC)	0.2	0.3	0.8	-0.4	-0.4	-0.9	-0.5	0.2
Blood Eosinophil Count	0.2	1.8	7.2	-0.7	-0.9	-0.7	0.5	2.7
Waist Hip Ratio (WHR)	0.2	0.8	1.1	0.5	-0.9	1.0	-0.8	1.1
Neuroticism	0.2	0.5	1.3	-0.5	0.8	-0.5	-1.1	-0.3
Sensitivity / hurt feelings	0.2	0.4	1.8	0.1	1.4	-0.2	0.3	-0.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.2	-0.7	-0.1	-0.8	-0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.8	-0.0	0.9	0.9	0.1
Supplements: Glucosamine	0.2	0.3	1.3	-0.2	-1.2	-0.0	-0.2	-0.4
Nervous feelings	0.2	0.4	1.2	-0.0	0.8	0.0	0.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.2	-0.1	1.1	0.2	-0.5	0.6
Had menopause	0.2	0.3	0.9	0.1	0.2	0.4	-0.7	-0.9
Allergy	0.2	0.3	0.9	0.1	-0.9	0.3	-0.8	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.4	1.2	-0.8	1.1	0.6	0.7
Tense / ‘highly strung’	0.2	0.3	1.1	0.0	1.1	-0.3	0.2	0.1
Loud music exposure frequency	0.2	0.2	0.6	-0.3	0.3	-0.8	-0.1	-0.4
Headache pain in last month	0.2	0.4	0.6	-0.7	0.8	-0.6	-0.3	-0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.5	0.2	0.8	-0.0	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.8	1.6	-0.8	0.5	-0.7	-1.1	-1.3
Medication: Omeprazole	0.2	0.2	0.7	0.3	0.3	0.3	-0.3	0.8
Medication: Seretide 50 evohaler	0.2	0.3	0.7	-0.2	-0.6	0.3	-0.8	0.5
Suffer from ‘nerves’	0.2	0.4	0.7	0.8	0.6	0.8	-0.1	-0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.3	-0.2	-1.1	-0.0	-0.4	0.1
Leg fat-free mass (right)	0.2	0.8	2.1	-1.5	-0.7	-1.1	-0.6	-0.3
Average weekly red wine intake	0.2	0.3	0.6	0.4	-0.8	-0.0	0.8	0.6
Medication: Paracetamol	0.2	0.3	0.8	-0.7	-0.2	-0.9	0.2	0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.0	0.2	0.1	0.2	-0.1	1.0
Alcohol drinker status: Previous	0.2	0.2	0.5	0.2	0.7	0.1	-0.7	-0.2
HDL Cholesterol	0.1	0.2	0.3	0.4	-0.4	0.2	0.4	0.6
Ulcerative Colitis	0.1	0.2	0.5	-0.2	0.3	-0.5	-0.7	0.0
Allergy or Eczema	0.1	0.1	0.3	0.2	-0.5	0.1	0.6	0.3
Respiratory disease	0.1	0.2	0.6	-0.7	0.2	-0.8	0.3	-0.2
Chronotype (morning person)	0.1	0.2	0.7	-0.3	-0.5	-0.2	-0.1	-0.8
Hair Pigment	0.1	3.7	14.4	1.2	-0.4	1.5	-0.7	3.8
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.1	0.2	-0.4	0.0	-0.7
Impedance of leg (right)	0.1	0.3	0.4	0.4	0.6	0.5	-0.4	0.6
Leg fat-free mass (left)	0.1	0.6	1.3	-1.1	-1.0	-0.7	-0.6	0.1
Fed-up feelings	0.1	0.2	0.6	-0.3	0.0	-0.1	-0.7	0.8
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.4	-0.2	0.6	0.0	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.0	0.3	0.3	-0.5	-0.1
Impedance of leg (left)	0.1	0.4	1.7	0.0	1.3	-0.1	-0.2	0.3
Leg predicted mass (left)	0.1	0.7	1.6	-1.3	-1.0	-0.8	-0.7	0.1
Forced vital capacity (FVC)	0.1	0.3	0.7	-0.4	0.4	-0.4	-0.4	-0.8
Heart attack	0.1	0.2	0.8	0.2	-0.3	0.2	0.1	0.9
Father’s age at death	0.1	0.2	0.5	-0.2	-0.1	0.3	-0.5	-0.7
Number of full brothers	0.1	0.2	0.3	-0.5	0.2	-0.5	-0.4	0.5
Medication: Ibuprofen	0.1	0.1	0.6	-0.1	0.8	0.2	0.0	-0.3
Medication: Allopurinol	0.1	0.1	0.3	0.1	0.3	-0.4	0.2	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	0.1	-0.4	-0.2	0.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.5	0.0	-0.4	0.7	-0.4	0.1
Breast cancer (self-reported)	0.1	0.2	0.4	0.2	0.6	-0.1	0.4	-0.5
Medication: Gliclazide	0.1	0.1	0.3	0.1	-0.4	0.4	-0.6	0.2
Leg predicted mass (right)	0.1	0.8	2.0	-1.4	-0.7	-1.0	-0.6	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	-0.0	0.4	0.3	-0.6	0.5
Blood White Count	0.0	0.0	0.1	0.0	0.4	0.1	-0.1	-0.2
Tanning	0.0	0.1	0.3	0.2	-0.1	-0.0	0.5	0.3
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.2	-0.2	-0.5	-0.0	0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.2	0.3	0.5	-0.4	0.5	-0.1	0.3
Family relationship satisfaction	0.0	0.1	0.1	-0.2	0.1	-0.3	-0.3	-0.2
Friendships satisfaction	0.0	0.0	0.1	0.0	-0.3	-0.1	0.2	0.1

Hub : Genes

MAP4K5

Models

Trait associations