Hub : Genes

MAP4K5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1610	0.0450	1.2e-06	0.079	NA	0.076	NA	0.079	1.5e-06	NA	2.4e-06	NA	1.6e-06
2	YFS	Blood	0.0137	0.0079	2.9e-02	0.012	-0.001	0.004	0	0.003	6.7e-05	0.82000	1.3e-02	0.31	2.6e-02
3	TCGA	Breast Invasive Carcinoma	0.0265	0.0133	2.6e-03	0.021	0.013	0.014	NA	0.019	2.5e-05	0.00085	4.6e-04	NA	8.0e-05
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0370	0.0185	6.8e-04	0.010	0.026	0.021	NA	0.021	2.3e-02	0.00055	1.8e-03	NA	1.6e-03
5	TCGA	Lung Squamous Cell Carcinoma	0.0709	0.0287	2.7e-04	0.003	0.022	0.014	NA	0.013	1.5e-01	0.00130	8.3e-03	NA	1.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.8	2.7	-0.4	0.5	-0.3	-0.8	1.6
Bipolar Disorder or Schizophrenia	0.9	2.2	8.0	1.1	0.4	1.2	-0.4	2.8
Depressed Affect (Nagel 2018)	0.5	1.0	2.8	-1.1	0.1	-0.9	-1.7	-0.0
Depression (Nagel 2018)	0.6	0.9	2.6	-0.9	1.0	-0.5	-1.6	-0.3
Intelligence (Savage-Jansen 2018)	0.8	2.5	6.0	-1.6	0.0	-1.7	-1.0	-2.5
Neuroticism (Nagel 2018)	0.7	1.7	2.6	-1.3	1.4	-1.4	-1.6	-0.8
Schizophrenia (2018)	1.1	2.4	5.4	1.7	0.2	1.8	0.2	2.3
Schizophrenia vs Biploar Disorder	1.0	1.3	3.6	1.6	0.1	1.9	0.1	0.5
Worry (Nagel 2018)	0.5	1.0	2.3	-0.5	1.5	-0.4	-0.7	-1.3
Alzheimer’s Disease (in mother)	1.7	2.0	8.9	-0.2	-3.0	-0.3	-0.0	0.9
Alzheimer’s Disease (in father)	3.0	3.3	5.7	1.5	-1.6	0.5	2.4	2.4
Alzheimer’s Disease (including proxy)	3.2	4.7	17.4	0.3	-4.2	-0.0	0.7	2.3
Crohns Disease (2017)	0.5	1.2	3.8	-0.3	-0.6	-1.2	0.3	1.9
Irritable Bowel Disease (IBD)	0.3	0.8	1.8	-0.5	-0.8	-1.3	-0.2	1.1
Ulcerative Colitis (UC)	0.2	0.3	0.8	-0.4	-0.4	-0.9	-0.5	0.2
Major Depression (MDD)	0.3	0.3	0.8	0.9	-0.4	0.4	0.4	-0.6
Reaction Time	0.4	0.8	2.7	0.5	-0.4	0.3	0.7	1.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.3	-0.8	0.6	-0.9	-0.8	-1.5
Breast Cancer	0.3	0.8	1.5	-0.7	0.9	-1.2	0.4	-1.1
Ovarian Cancer	0.4	0.5	1.0	-0.6	0.5	-1.0	0.1	-0.9
Prostate Cancer	1.6	2.2	5.8	1.6	0.4	1.0	2.4	1.2
Age at First Birth	0.4	0.5	2.0	-0.4	0.5	-0.3	-0.4	-1.4
Bipolar Disorder (2011)	0.5	0.5	2.1	-0.5	-0.1	0.1	-1.5	0.2
Body Mass Index (BMI) (2010)	1.1	1.5	6.2	-0.3	-1.0	-0.2	0.2	2.5
Coronary Artery Disease (CAD)	1.3	1.5	3.3	1.3	-1.6	1.8	-0.1	0.2
Crohns Disease (2012)	0.5	0.9	2.7	-1.0	0.4	-1.7	-0.2	0.7
Mean Putamen Volume	3.5	4.0	5.7	2.1	-1.6	2.4	1.4	2.3
Fasting Glucose	0.9	1.0	3.6	0.1	-1.9	1.1	-0.4	-0.1
HbA1C	0.4	0.5	1.4	0.8	-0.0	1.2	-0.4	0.5
HDL Cholesterol	0.1	0.2	0.3	0.4	-0.4	0.2	0.4	0.6
LDL Cholesterol	0.7	1.2	2.8	0.9	1.1	0.9	0.4	1.7
Lupus	1.1	1.7	3.5	-1.0	1.7	-1.0	0.2	-1.9
Neuroticism (2016)	0.6	0.8	1.3	-1.0	0.8	-0.8	-1.1	0.5
Primary Biliary Cirrhosis	1.4	1.9	8.4	0.6	-0.5	0.2	0.8	2.9
Rheumatoid Arthritis	1.0	1.4	3.0	-1.6	1.0	-1.7	-0.5	0.1
Schizophrenia (2014)	1.5	3.2	6.1	2.0	0.5	2.4	-0.4	2.5
Triglycerides	0.4	0.7	1.3	1.0	0.2	1.1	0.1	1.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.5	-0.6	-0.6	-0.1	-1.6	1.0
Ulcerative Colitis	0.1	0.2	0.5	-0.2	0.3	-0.5	-0.7	0.0
Blood Eosinophil Count	0.2	1.8	7.2	-0.7	-0.9	-0.7	0.5	2.7
Blood Platelet Count	3.0	34.2	74.8	7.6	0.7	8.7	3.8	4.9
Blood Red Count	1.0	9.4	27.4	0.1	4.0	0.4	-1.9	-5.2
Blood White Count	0.0	0.0	0.1	0.0	0.4	0.1	-0.1	-0.2
Heel T-Score	0.8	6.4	22.7	-2.0	0.0	-0.9	-4.8	-2.1
BMI	0.8	4.9	19.3	1.1	-1.0	1.5	0.7	4.4
Height	0.7	13.4	22.2	-4.5	-1.4	-3.1	-3.7	-4.7
Waist Hip Ratio (WHR)	0.2	0.8	1.1	0.5	-0.9	1.0	-0.8	1.1
Systolic Blood Pressure	3.0	15.2	30.7	5.5	0.7	5.1	2.3	3.7
Smoking Status	0.4	1.1	1.9	-1.4	-0.9	-1.2	-1.1	-0.3
Allergy or Eczema	0.1	0.1	0.3	0.2	-0.5	0.1	0.6	0.3
Cardiovascular Disease	4.4	14.4	22.6	4.8	0.9	4.7	2.3	4.6
Hypothyroidism (self reported)	0.4	1.0	2.3	0.7	1.5	0.2	1.4	-0.5
Respiratory disease	0.1	0.2	0.6	-0.7	0.2	-0.8	0.3	-0.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.5	0.7	-1.9	0.9	-0.1	0.9
Lung FEV1/FVC ratio	2.9	14.6	23.6	4.1	-2.8	4.2	2.8	4.9
Lung FVC	0.3	1.5	4.5	0.8	2.1	-0.0	1.5	0.2
Neuroticism	0.2	0.5	1.3	-0.5	0.8	-0.5	-1.1	-0.3
Chronotype (morning person)	0.1	0.2	0.7	-0.3	-0.5	-0.2	-0.1	-0.8
Hair Pigment	0.1	3.7	14.4	1.2	-0.4	1.5	-0.7	3.8
Tanning	0.0	0.1	0.3	0.2	-0.1	-0.0	0.5	0.3
Hand grip strength (left)	0.6	1.5	5.6	-0.7	-1.0	-0.1	-2.4	-0.4
Number of treatments/medications taken	1.0	1.9	3.5	1.3	1.9	0.8	1.6	0.9
Average weekly spirits intake	0.5	0.6	0.9	0.5	-1.0	0.8	0.8	0.8
Sensitivity / hurt feelings	0.2	0.4	1.8	0.1	1.4	-0.2	0.3	-0.0
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.3	-1.0	1.2	-0.8	-1.5	-0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.1	0.2	-0.4	0.0	-0.7
Relative age of first facial hair	2.2	4.5	9.4	-1.8	2.6	-1.7	-0.5	-3.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	0.6	-0.5	0.5	1.3	0.1
Ever used hormone-replacement therapy (HRT)	1.1	1.4	5.7	-1.0	-0.2	-0.4	-2.4	-0.5
Ever had hysterectomy (womb removed)	1.3	1.5	3.3	-0.7	1.6	-0.6	-1.8	-0.9
Systolic blood pressure, automated reading	1.9	5.6	10.4	3.2	0.7	2.9	1.2	2.7
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.8	1.0	-1.3	1.2	0.4	0.8
Angina	0.9	1.2	1.9	1.0	-0.9	1.1	1.4	1.1
Medication for hormone replacement therapy	0.4	0.5	0.9	-0.6	-1.0	-0.2	-0.9	0.4
Vitamin and mineral supplements	0.3	0.3	0.8	0.1	0.9	0.2	-0.5	-0.8
Supplements: Zinc	1.2	1.3	2.7	-1.2	0.6	-1.6	-0.4	-1.4
Medication: Co-codamol	0.6	0.7	1.4	-1.0	0.8	-1.2	-0.3	-0.6
Medication: Metformin	1.1	1.5	2.6	1.2	-1.2	1.3	0.7	1.6
Diabetes (father)	3.5	4.3	8.2	2.9	-0.1	2.8	1.8	1.6
Diabetes (mother)	1.0	1.3	5.0	-0.6	-0.8	0.2	-0.6	2.2
Severe depression (siblings)	0.8	0.9	2.2	-0.7	0.6	0.2	-1.5	-1.1
Pack years adult smoking proportion	1.6	2.4	7.3	0.2	-2.0	0.6	0.1	2.7
Impedance of leg (right)	0.1	0.3	0.4	0.4	0.6	0.5	-0.4	0.6
Leg fat-free mass (left)	0.1	0.6	1.3	-1.1	-1.0	-0.7	-0.6	0.1
Trunk fat percentage	1.2	4.9	16.5	1.1	0.8	1.1	2.3	4.1
Hand grip strength (right)	0.5	1.3	3.2	-0.6	-1.7	0.1	-1.8	0.1
Townsend deprivation index at recruitment	1.0	1.4	3.1	0.8	1.8	0.0	1.7	0.6
Current tobacco smoking	1.0	1.6	2.7	1.6	-0.5	1.5	1.4	1.0
Average weekly fortified wine intake	1.2	1.4	4.5	0.2	2.1	0.5	0.4	-1.5
Maternal smoking around birth	0.3	0.4	1.1	-0.3	-1.0	0.3	-0.6	-0.6
Fed-up feelings	0.1	0.2	0.6	-0.3	0.0	-0.1	-0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.4	-0.0	1.6	-0.2	0.0	-0.5
Relative age voice broke	2.1	3.2	4.3	-2.1	1.6	-1.8	-2.0	-1.3
Taking other prescription medications	0.8	1.3	4.1	0.1	2.0	-0.5	1.4	0.3
Age when periods started (menarche)	1.3	3.0	12.4	-0.1	1.3	0.2	-1.1	-3.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.1	-0.6	0.4	-0.2	-1.4	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	6.7	-1.2	0.8	-0.9	-2.2	-2.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.2	-0.7	-0.1	-0.8	-0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.1	0.4	-0.8	0.3	0.1	-1.0
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.4	-0.2	0.6	0.0	0.4
High blood pressure	4.1	11.3	18.9	4.3	1.5	4.0	3.0	3.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.8	-0.0	0.9	0.9	0.1
Multivitamins +/- minerals	0.4	0.5	1.0	-0.9	-0.4	-1.0	0.1	0.7
Stomach or abdominal pain in last month	1.8	2.2	4.1	2.0	0.9	2.0	1.0	1.1
Supplements: Glucosamine	0.2	0.3	1.3	-0.2	-1.2	-0.0	-0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.0	0.3	0.3	-0.5	-0.1
Medication: Atenolol	1.8	2.2	5.1	2.0	-0.2	2.3	1.3	0.4
Medication: Levothyroxine sodium	0.5	0.9	1.6	0.9	1.3	0.6	1.2	-0.6
Sitting height	1.6	11.6	15.2	-3.8	-2.6	-2.8	-3.9	-3.8
Chronic bronchitis/emphysema (father)	2.4	2.8	4.8	-2.2	-1.4	-1.8	-1.8	-0.9
High blood pressure (mother)	1.7	2.4	9.1	1.0	3.0	0.3	1.3	0.1
Body mass index (BMI)	0.9	4.0	16.4	0.9	-0.6	1.0	1.2	4.0
Impedance of leg (left)	0.1	0.4	1.7	0.0	1.3	-0.1	-0.2	0.3
Leg predicted mass (left)	0.1	0.7	1.6	-1.3	-1.0	-0.8	-0.7	0.1
Trunk fat mass	0.8	3.3	13.4	0.6	0.1	0.8	1.5	3.7
Waist circumference	1.2	4.4	17.6	0.9	-0.7	1.2	1.3	4.2
Number of incorrect matches in round	0.4	0.6	1.0	-0.6	-1.0	-0.1	-0.9	1.0
Past tobacco smoking	1.8	3.4	7.8	2.6	-0.3	2.8	1.3	-0.6
Alcohol usually taken with meals	0.4	0.6	2.0	0.1	0.6	-0.7	0.4	-1.4
Nervous feelings	0.2	0.4	1.2	-0.0	0.8	0.0	0.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.2	-0.1	1.1	0.2	-0.5	0.6
Hearing difficulty/problems with background noise	2.2	3.5	5.0	-1.5	1.8	-2.2	-1.4	-2.1
Hair/balding pattern: Pattern 2	0.4	0.5	1.5	1.1	-0.1	1.2	0.1	0.2
Had menopause	0.2	0.3	0.9	0.1	0.2	0.4	-0.7	-0.9
Had other major operations	2.3	2.8	8.0	1.3	0.7	0.4	2.8	1.9
Forced vital capacity (FVC)	0.1	0.3	0.7	-0.4	0.4	-0.4	-0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.9	-1.2	0.5	-0.9	-1.7	-1.7
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.9	1.5	-0.1	2.0	-0.7	0.5
Qualifications: None of the above	1.4	3.0	11.3	-0.7	-1.4	-1.0	0.2	3.4
Financial difficulties in last 2 years	1.0	1.4	2.3	1.4	0.9	0.9	1.5	1.1
Mouth/teeth dental problems	1.4	2.2	3.2	-1.6	-0.8	-1.1	-1.8	-1.8
Heart attack	0.1	0.2	0.8	0.2	-0.3	0.2	0.1	0.9
Allergy	0.2	0.3	0.9	0.1	-0.9	0.3	-0.8	0.3
Pain all over the body in last month	0.9	0.9	4.2	-0.3	0.1	0.5	-2.1	0.0
Diabetes (self-reported)	0.4	0.6	1.8	0.5	-1.3	0.8	-0.2	0.4
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.2	-0.2	-0.5	-0.0	0.0	-0.2
Medication: Ramipril	1.0	1.2	4.3	0.7	2.1	0.2	0.2	1.1
Medication: Simvastatin	0.6	0.8	1.7	1.0	0.9	1.3	-0.3	0.7
Fluid intelligence score	0.6	1.3	3.7	-0.6	-0.0	-0.2	-1.5	-1.9
Illnesses of siblings	1.1	1.6	3.3	-1.0	-1.3	-0.5	-1.8	1.3
Neuroticism score	0.5	1.1	1.9	-0.9	1.4	-1.1	-0.8	-0.8
Weight	0.3	1.4	5.7	-0.6	-0.9	-0.0	-0.1	2.4
Impedance of arm (right)	0.9	4.3	11.7	1.1	3.4	0.3	2.4	-1.6
Arm fat percentage (right)	1.5	6.0	19.4	1.6	0.4	1.6	2.3	4.4
Trunk fat-free mass	0.7	4.1	6.9	-2.5	-1.9	-1.7	-2.6	-0.8
Hip circumference	0.6	2.8	12.3	0.3	-0.1	0.3	1.2	3.5
Time employed in main current job	2.4	2.7	6.0	2.0	-1.5	2.4	0.6	1.1
Alcohol intake versus 10 years previously	1.4	2.1	4.0	-2.0	-1.2	-1.8	-0.9	1.2
Father’s age at death	0.1	0.2	0.5	-0.2	-0.1	0.3	-0.5	-0.7
Worrier / anxious feelings	1.7	3.3	4.5	-2.0	1.3	-2.1	-1.5	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	0.4	1.4	0.2	0.2	0.4
Falls in the last year	0.3	0.4	1.4	0.3	0.6	-0.1	1.2	-0.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	0.3	0.2	-0.3	1.2	1.1
Number of live births	0.7	1.0	3.0	0.7	-1.7	0.6	-0.2	1.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.4	1.2	-0.8	1.1	0.6	0.7
Pulse rate	1.1	1.8	3.3	1.7	-0.7	1.5	0.5	1.8
Happiness	0.8	1.0	2.4	1.0	0.3	0.8	0.8	1.6
Noisy workplace	0.4	0.5	1.0	-0.4	-0.7	-0.2	-0.8	1.0
Qualifications: A levels/AS levels or equivalent	2.9	6.3	25.7	-0.4	2.2	-0.4	-0.8	-5.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.8	-0.4	1.2	-0.4	0.4	-1.3
Mouth/teeth dental problems: Dentures	3.2	5.4	9.1	2.3	-1.2	2.0	2.7	3.0
Asthma	0.6	1.1	2.3	0.6	1.4	0.2	1.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.9	-0.3	1.7	-0.3	-0.2	-1.1
Medication: Cholesterol lowering	0.7	1.2	2.2	1.2	1.2	1.5	0.0	0.7
Depression (self-reported)	0.5	0.5	1.4	0.7	-0.2	0.4	1.2	0.8
Medication: Lansoprazole	1.7	1.9	4.2	-1.4	2.1	-0.7	-1.2	-1.2
Prospective memory result	0.3	0.3	0.9	-0.6	0.9	-0.4	-0.4	-0.4
Lung cancer (father)	1.2	1.4	3.2	-1.0	-0.5	-1.4	0.7	1.8
Illnesses of mother	0.7	0.9	3.3	-0.7	-1.8	-0.6	-0.2	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.2	0.3	0.5	-0.4	0.5	-0.1	0.3
Pulse wave Arterial Stiffness index	0.6	0.7	3.2	-0.1	0.1	-0.1	0.4	1.8
Impedance of arm (left)	0.8	3.7	11.1	0.9	3.3	0.2	2.2	-1.2
Arm fat mass (right)	0.8	3.3	13.8	0.7	-0.2	0.9	1.2	3.7
Trunk predicted mass	0.7	4.0	6.8	-2.5	-1.8	-1.6	-2.6	-0.9
Standing height	0.8	7.8	12.9	-3.6	-0.8	-2.7	-2.7	-3.2
Length of working week for main job	0.9	1.0	3.1	0.1	-0.5	-0.4	1.2	1.7
Exposure to tobacco smoke at home	1.9	2.1	6.0	0.2	-2.4	-0.4	1.1	1.7
Breastfed as a baby	0.3	0.3	1.5	0.1	1.2	0.1	0.3	0.2
Tense / ‘highly strung’	0.2	0.3	1.1	0.0	1.1	-0.3	0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.8	-0.1	1.3	-0.4	-0.0	-0.2
Hair/balding pattern: Pattern 4	1.1	2.7	6.6	-1.3	-2.3	-0.1	-2.6	0.3
Birth weight of first child	1.2	2.1	7.0	0.6	0.9	1.1	-1.0	-2.7
Peak expiratory flow (PEF)	1.5	3.6	5.6	2.3	-0.0	2.1	2.4	1.6
Pulse wave reflection index	0.5	0.6	1.9	-0.7	1.4	-0.6	-0.1	-0.3
Ever highly irritable/argumentative for 2 days	1.9	2.3	3.8	1.9	1.1	2.0	1.4	0.8
Loud music exposure frequency	0.2	0.2	0.6	-0.3	0.3	-0.8	-0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	1.0	0.7	1.1	0.3	-0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.4	1.2	1.0	0.8	0.4	-0.8
Blood clot in the leg (DVT)	1.0	1.4	2.0	-1.4	1.2	-0.7	-1.4	-1.0
Medication: Paracetamol	0.3	0.4	1.0	-0.8	0.7	-1.0	-0.0	-0.0
Headache pain in last month	0.2	0.4	0.6	-0.7	0.8	-0.6	-0.3	-0.6
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	11.0	-3.0	-1.0	-3.3	-1.1	-1.5
Glaucoma (self-reported)	0.4	0.5	1.4	-0.6	-1.2	-0.3	-0.6	-0.4
Gout (self-reported)	0.9	1.2	2.4	1.1	0.5	0.4	1.5	1.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.7	0.4	1.4	-0.3	1.7	-0.1
Medication: Amlodipine	4.1	5.7	9.3	2.8	-0.1	2.5	2.3	3.1
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.2	-1.5	-0.0	-1.4	-0.6	-1.4
Birth weight	2.4	5.1	14.8	-1.8	1.7	-1.0	-2.0	-3.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.5	0.2	0.8	-0.0	-0.4
High blood pressure (siblings)	0.8	1.2	2.4	1.5	1.0	1.1	1.2	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	1.6	-0.8	0.5	-0.7	-1.1	-1.3
Body fat percentage	1.9	7.5	25.7	1.7	0.3	1.8	2.4	5.1
Leg fat percentage (right)	2.6	9.5	32.6	2.2	-0.9	2.5	1.6	5.7
Arm fat-free mass (right)	0.7	3.4	5.7	-2.2	-2.0	-1.4	-2.4	0.5
Exposure to tobacco smoke outside home	0.3	0.4	0.6	0.7	0.6	0.4	0.6	0.8
Comparative body size at age 10	0.7	1.8	7.0	-0.6	-1.0	-0.5	0.7	2.6
Number of full brothers	0.1	0.2	0.3	-0.5	0.2	-0.5	-0.4	0.5
Worry too long after embarrassment	0.5	0.8	2.2	-0.5	1.5	-1.1	-0.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	0.4	-0.8	0.1	0.6	1.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.3	0.9	0.8	0.1	1.2	0.3
Number of children fathered	1.1	1.3	3.6	-1.2	-1.9	-0.7	-0.9	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.3	-1.0	-0.8	-1.5	0.1	0.6
Age at first live birth	2.2	3.9	7.2	-2.5	1.2	-2.7	-1.5	-1.6
Pulse wave peak to peak time	0.8	0.9	4.1	-0.2	-0.2	-0.1	-0.6	-2.0
Health satisfaction	0.6	0.8	1.7	1.1	0.1	1.0	0.4	1.3
Shortness of breath walking on level ground	0.5	0.6	2.4	-0.4	-0.0	-0.8	0.1	1.5
Qualifications: College or University degree	3.0	9.5	26.0	-2.3	2.6	-2.1	-2.3	-5.1
Eye problems/disorders: None of the above	0.6	0.7	3.0	-0.0	1.7	-0.5	0.3	0.2
Mouth/teeth dental problems: Loose teeth	1.3	1.6	4.4	0.9	2.1	0.7	1.5	0.2
Emphysema/chronic bronchitis	0.5	0.6	1.3	-1.2	0.3	-1.1	-0.6	-0.1
Medication for pain relief, constipation, heartburn	0.4	0.7	2.9	-0.6	-1.7	-0.5	-0.3	0.3
Neck or shoulder pain in last month	1.5	2.1	4.8	1.2	2.2	1.3	1.4	0.6
Medication: Blood pressure	2.8	4.9	10.6	2.9	0.6	3.3	1.0	2.1
Angina (self-reported)	0.7	0.9	1.5	0.7	-0.7	1.0	1.2	1.1
Migraine (self-reported)	1.1	1.3	2.6	-1.5	-1.1	-1.6	-0.3	0.8
Medication: Ibuprofen	0.1	0.1	0.6	-0.1	0.8	0.2	0.0	-0.3
Medication: Allopurinol	0.1	0.1	0.3	0.1	0.3	-0.4	0.2	0.5
Medication: Omeprazole	0.2	0.2	0.7	0.3	0.3	0.3	-0.3	0.8
Medication: Seretide 50 evohaler	0.2	0.3	0.7	-0.2	-0.6	0.3	-0.8	0.5
Mean time to correctly identify matches	1.1	2.2	4.8	1.4	-0.2	1.0	1.8	2.2
Heart disease (mother)	0.5	0.7	2.0	0.1	-0.7	0.6	-1.4	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	0.1	-0.4	-0.2	0.2	0.3
Whole body fat mass	1.0	4.2	17.1	0.8	-0.3	1.0	1.4	4.1
Leg fat mass (right)	1.4	5.3	20.7	1.2	-1.0	1.5	1.1	4.6
Arm predicted mass (right)	0.5	2.6	4.5	-1.7	-2.1	-1.0	-2.0	0.6
Pulse rate, automated reading	0.7	2.4	7.3	0.4	-2.1	0.2	-0.2	2.7
Alcohol intake frequency.	0.5	1.1	1.8	0.8	-1.1	1.3	-0.7	1.2
Comparative height size at age 10	0.4	2.0	2.8	-1.7	1.4	-1.4	-0.9	-1.6
Number of full sisters	1.2	1.4	2.2	-1.5	1.3	-1.1	-1.4	-0.1
Suffer from ‘nerves’	0.2	0.4	0.7	0.8	0.6	0.8	-0.1	-0.2
Overall health rating	1.3	2.8	4.4	1.8	1.2	1.2	1.9	2.1
Chest pain or discomfort	1.5	2.1	3.2	1.8	1.7	1.6	1.4	0.3
Had major operations	1.2	1.5	3.8	-0.7	1.9	-1.4	0.9	-0.3
Age at last live birth	2.0	2.9	6.5	-2.3	-0.5	-2.5	-1.4	-0.6
Family relationship satisfaction	0.0	0.1	0.1	-0.2	0.1	-0.3	-0.3	-0.2
Leg pain on walking	0.3	0.3	0.8	-0.6	-0.5	-0.9	-0.5	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.5	0.0	-0.4	0.7	-0.4	0.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	4.7	0.5	-0.6	-0.0	1.0	2.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.3	-0.2	-1.1	-0.0	-0.4	0.1
Medication: Aspirin	1.6	2.0	5.2	1.9	1.2	2.3	0.1	0.1
Supplements: Vitamin C	0.4	0.5	0.9	-0.7	-0.3	-0.3	-1.0	-0.9
Knee pain experienced in last month	0.7	1.1	3.2	0.6	-1.0	0.7	0.6	1.8
Hypertension (Self-reported)	4.7	13.1	22.2	4.7	1.2	4.4	3.4	3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	0.3	-0.8	1.0	-0.8	-0.2
Illnesses of father: Heart disease	0.6	0.8	2.0	0.5	0.3	1.1	-0.7	-1.4
Illnesses of siblings: Diabetes	1.7	2.1	5.7	1.7	1.0	0.7	2.4	0.7
Smoking status: Previous	4.8	7.2	14.8	-3.9	-0.7	-3.6	-2.7	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.0	-1.6	-0.8	-1.4	-2.0	-0.7
Whole body fat-free mass	0.4	2.5	4.5	-2.1	-1.6	-1.4	-1.9	-0.5
Leg fat-free mass (right)	0.2	0.8	2.1	-1.5	-0.7	-1.1	-0.6	-0.3
Arm fat percentage (left)	1.6	6.4	20.0	1.8	0.6	1.7	2.4	4.5
Average weekly red wine intake	0.2	0.3	0.6	0.4	-0.8	-0.0	0.8	0.6
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.2	1.4	1.5	1.3	0.6	-0.5
Mood swings	0.4	0.8	1.4	-0.4	1.2	-0.9	-0.8	-0.8
Loneliness, isolation	1.0	1.4	4.0	1.0	0.9	0.4	2.0	1.1
Long-standing illness, disability or infirmity	0.6	1.0	1.5	1.2	0.9	0.7	1.2	0.7
Ever had bowel cancer screening	0.4	0.5	1.5	0.3	0.4	-0.1	1.2	0.9
Diabetes diagnosed by doctor	0.8	1.3	3.0	1.1	-1.7	1.3	0.5	0.5
Ever had stillbirth, spontaneous miscarriage or termination	4.5	4.8	8.4	2.3	2.9	2.0	2.4	0.9
Friendships satisfaction	0.0	0.0	0.1	0.0	-0.3	-0.1	0.2	0.1
Qualifications: nursing, teaching	0.7	1.1	2.5	0.6	0.7	0.3	1.6	-1.5
Commuting to job workplace: Walk	0.6	0.6	1.4	1.2	0.5	1.0	0.0	-0.5
Eye problems/disorders: Cataract	0.4	0.5	1.7	-0.4	-0.4	0.3	-1.3	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.5	-1.2	1.1	-1.2	-0.6	0.2
Medication for cholesterol	1.9	2.9	4.3	-2.1	-0.1	-1.8	-1.7	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.0	-1.4	-0.1	-1.1	-0.9	-1.1
Back pain experienced in last month	0.3	0.5	1.5	-0.2	1.2	-0.6	0.5	0.4
Mineral and other dietary supplements	0.7	0.9	1.9	0.9	0.8	1.2	0.2	1.4
Breast cancer (self-reported)	0.1	0.2	0.4	0.2	0.6	-0.1	0.4	-0.5
Asthma (self-reported)	0.5	1.0	2.7	0.7	1.1	0.3	1.6	-0.6
Osteoporosis (self-reported)	0.6	0.8	2.4	0.8	-0.3	0.1	1.5	0.9
Osteoarthritis (self-reported)	0.4	0.6	1.3	0.4	-1.1	0.3	0.4	1.1
Medication: Aspirin	1.5	2.0	5.8	1.8	1.1	2.4	-0.0	0.1
Medication: Gliclazide	0.1	0.1	0.3	0.1	-0.4	0.4	-0.6	0.2
Illnesses of father: None of the above (group 1)	1.9	2.3	5.6	-2.2	-0.2	-2.4	-0.6	1.0
Smoking status: Current	0.8	1.3	2.4	1.6	-0.2	1.3	1.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.8	1.4	0.5	0.8	1.3	0.1
Whole body water mass	0.5	2.7	4.6	-2.1	-1.7	-1.4	-2.0	-0.4
Leg predicted mass (right)	0.1	0.8	2.0	-1.4	-0.7	-1.0	-0.6	-0.4
Arm fat mass (left)	0.8	3.1	13.2	0.6	-0.1	0.9	1.1	3.6
Number of self-reported non-cancer illnesses	1.1	2.0	3.6	1.7	0.5	1.3	1.9	1.1
Average weekly champagne plus white wine intake	0.5	0.7	2.4	0.1	0.5	0.6	-0.8	-1.5
Miserableness	0.5	0.9	2.3	-0.8	0.7	-0.6	-1.5	-0.6
Guilty feelings	0.3	0.5	1.0	0.3	1.0	-0.2	0.9	-0.7
Wears glasses or contact lenses	1.7	1.9	4.2	0.7	1.9	0.8	0.8	-2.0
Ever taken oral contraceptive pill	0.5	0.5	1.2	1.1	-0.2	0.5	1.1	-0.2
Hearing aid user	1.3	1.5	3.3	-1.8	0.5	-1.4	-1.3	-0.3
Mother’s age at death	1.0	1.3	3.0	-1.6	0.6	-1.7	-0.5	-0.4
Financial situation satisfaction	0.6	0.8	2.1	-0.1	0.8	-0.0	-1.0	1.4
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	0.2	0.9	-0.5	1.0	0.6
Commuting to job workplace: Public transport	0.6	0.7	2.1	0.3	1.4	0.7	-0.5	-0.8
Eye problems/disorders: Glaucoma	0.5	0.5	1.2	-0.7	-1.1	-0.4	-0.7	-0.6
Medication: Blood pressure	4.2	7.9	13.0	3.6	0.9	3.1	3.1	2.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	-0.5	0.6	-0.6	-0.1	1.1
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.0	-1.4	-1.4	-1.4	-1.1	-0.7
High cholesterol (Self-reported)	2.4	4.2	9.5	2.8	1.3	3.1	1.1	0.7
Medication: Bendroflumethiazide	2.6	3.9	6.7	2.3	0.6	2.0	1.8	2.6
Medication: Paracetamol	0.2	0.3	0.8	-0.7	-0.2	-0.9	0.2	0.0
Medication: Lisinopril	1.3	1.6	2.6	1.6	-0.6	1.4	1.2	1.3
Medication: Atorvastatin	3.6	4.4	6.8	2.6	2.1	2.0	2.1	1.5
Illnesses of father: High blood pressure	3.0	3.7	7.7	2.7	1.7	2.8	0.6	-0.2
Alcohol drinker status: Never	0.9	1.1	1.7	0.5	-1.3	1.0	-0.8	1.3
Ever smoked	1.2	2.1	4.1	-1.6	1.9	-2.0	-0.2	-0.0
Basal metabolic rate	0.3	1.8	3.1	-1.8	-1.5	-1.1	-1.5	0.4
Leg fat percentage (left)	2.2	8.1	29.2	1.9	-0.4	2.1	1.8	5.4
Arm fat-free mass (left)	0.5	2.5	4.2	-1.9	-1.8	-1.1	-2.1	0.5
Number of operations (self-reported)	0.4	0.5	2.0	-0.1	0.6	-0.5	1.4	0.1
Average weekly beer plus cider intake	0.9	1.3	2.3	-1.5	-0.2	-1.1	-1.1	1.1
Irritability	0.4	0.7	1.8	-1.0	0.3	-1.4	-0.0	0.6
Risk taking	0.3	0.5	0.8	-0.8	0.1	-0.9	0.3	0.9
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	1.1	-0.2	0.8	1.2	0.2
Fractured/broken bones in last 5 years	1.1	1.5	2.2	1.5	0.6	1.2	1.1	1.5
Age started oral contraceptive pill	1.1	1.4	2.6	0.8	1.3	1.4	0.2	-1.6
Diastolic blood pressure, automated reading	1.1	3.5	8.6	2.2	-0.0	1.8	0.8	2.9
Ever depressed for a whole week	0.9	1.1	2.6	1.6	0.5	1.6	-0.2	0.4
Unable to work because of sickness or disability	0.7	1.0	1.9	-1.2	-0.3	-1.1	-1.4	0.5
Commuting to job workplace: Cycle	0.7	0.8	2.3	0.2	-1.2	0.6	-0.3	-1.5
Myopia	4.3	6.2	9.9	2.9	1.3	2.2	3.2	2.4
Vascular/heart problems diagnosed by doctor	4.6	12.5	20.8	-4.6	-1.7	-4.3	-3.1	-3.2
Cholesterol lowering medication	1.2	1.7	3.6	1.6	1.9	1.4	0.5	0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	-0.0	0.4	0.3	-0.6	0.5
Pain experienced in last month	0.6	1.1	2.4	-0.7	-1.3	-0.2	-0.9	-1.5
Supplements: Calcium	0.4	0.4	1.4	-0.8	0.2	-1.2	-0.1	0.3
Basal cell carcinoma (self-reported)	1.2	1.4	3.2	-0.5	1.6	-0.9	0.4	-1.8
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.0	0.2	0.1	0.2	-0.1	1.0
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.2	-1.3	1.5	-0.6	-1.4	-1.1
Heart disease (siblings)	0.7	0.9	1.7	0.8	1.3	0.3	1.3	-0.4
Alcohol drinker status: Previous	0.2	0.2	0.5	0.2	0.7	0.1	-0.7	-0.2
Pack years of smoking	1.6	2.4	6.7	0.5	-2.0	0.8	0.5	2.6
Impedance of whole body	0.4	1.8	6.6	0.8	2.6	0.4	1.2	-0.4
Leg fat mass (left)	1.2	4.9	19.5	1.0	-0.7	1.3	1.2	4.4
Arm predicted mass (left)	0.5	2.7	4.6	-1.9	-2.0	-1.0	-2.1	0.4