Best TWAS P=1.95e-10 · Best GWAS P=1.57e-76 conditioned to 4.13e-66
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | CEP112 | 0.18 | 0.01 | enet | 22 | 0.02 | 5.0e-02 | 7.4 | -5.4 | 8.0e-08 | -0.27 | 0.12 | 0.05 | FALSE |
| 2 | GTEx | Colon Transverse | DDX42 | 0.19 | 0.07 | lasso | 4 | 0.11 | 4.4e-06 | 2.6 | 5.3 | 1.2e-07 | -0.02 | 0.41 | 0.46 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | PRKCA | 0.25 | 0.21 | enet | 13 | 0.25 | 1.2e-11 | 7.2 | -5.2 | 1.9e-07 | -0.20 | 0.99 | 0.00 | FALSE |
| 4 | GTEx | Heart Left Ventricle | PRKCA | 0.42 | 0.24 | enet | 40 | 0.26 | 4.0e-14 | 7.2 | -6.4 | 1.9e-10 | -0.22 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Lung | TEX2 | 0.04 | 0.02 | enet | 13 | 0.01 | 5.0e-02 | -4.5 | -6.0 | 1.7e-09 | -0.07 | 0.13 | 0.14 | TRUE |
| 6 | GTEx | Lung | PRKCA | 0.20 | 0.01 | enet | 38 | 0.03 | 1.9e-03 | -5.3 | 5.1 | 2.9e-07 | 0.19 | 0.38 | 0.02 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | PRKCA | 0.15 | 0.01 | enet | 31 | 0.06 | 4.5e-06 | -5.7 | 5.7 | 1.3e-08 | 0.14 | 0.19 | 0.14 | FALSE |
| 8 | NTR | Blood | LIMD2 | 0.04 | 0.03 | blup | 304 | 0.03 | 2.2e-10 | -4.6 | 5.3 | 1.4e-07 | -0.03 | 0.04 | 0.95 | FALSE |
| 9 | YFS | Blood | ERN1 | 0.01 | 0.00 | bslmm | 309 | 0.00 | 5.9e-02 | -3.7 | 5.3 | 9.7e-08 | -0.03 | 0.02 | 0.20 | FALSE |