Hub : Genes

CEP112

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Sigmoid 0.180 0.0740 0.0071 0.012 NA 0.023 NA 0.000 1.1e-01 NA 5.0e-02 NA 3.1e-01
2 GTEx Muscle Skeletal 0.102 0.0432 0.0092 0.059 NA 0.048 NA 0.058 1.8e-06 NA 1.5e-05 NA 2.1e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 3.1 4.8 8.9 -3.0 -0.9
Bipolar Disorder or Schizophrenia 0.9 2.2 4.2 -2.0 0.5
Depressed Affect (Nagel 2018) 0.9 2.0 3.6 1.9 0.6
Depression (Nagel 2018) 0.5 0.8 1.4 -1.2 0.5
Intelligence (Savage-Jansen 2018) 0.4 1.2 1.7 -1.3 -0.8
Neuroticism (Nagel 2018) 1.3 3.1 3.6 1.9 1.6
Schizophrenia (2018) 0.5 1.0 2.0 -0.2 1.4
Schizophrenia vs Biploar Disorder 3.4 4.4 7.7 2.8 1.1
Worry (Nagel 2018) 1.5 3.2 6.2 0.6 2.5
Alzheimer’s Disease (in mother) 2.0 2.3 4.2 2.1 -0.7
Alzheimer’s Disease (in father) 1.8 2.0 2.6 1.2 -1.6
Alzheimer’s Disease (including proxy) 5.4 7.9 12.7 3.6 -1.7
Crohns Disease (2017) 0.0 0.0 0.1 0.0 -0.3
Irritable Bowel Disease (IBD) 0.5 1.2 1.3 -1.1 -1.1
Ulcerative Colitis (UC) 0.8 1.6 1.8 -1.4 -1.1
Major Depression (MDD) 0.8 1.0 2.0 -1.4 -0.2
Reaction Time 1.1 2.0 3.1 -0.9 -1.8
Verbal and Numeric Reasoning (VNR) 1.1 2.6 4.4 -2.1 0.9
Breast Cancer 0.6 1.5 2.8 0.4 -1.7
Ovarian Cancer 1.1 1.5 3.0 -0.1 1.7
Prostate Cancer 0.4 0.5 1.0 1.0 -0.2
Age at First Birth 0.1 0.2 0.3 -0.3 0.6
Bipolar Disorder (2011) 2.7 2.6 5.2 -2.3 -0.1
Body Mass Index (BMI) (2010) 0.8 1.1 1.9 -1.4 -0.5
Coronary Artery Disease (CAD) 0.2 0.3 0.5 -0.1 -0.7
Crohns Disease (2012) 0.1 0.1 0.2 0.1 -0.5
Mean Putamen Volume 0.5 0.6 0.9 0.9 -0.6
Fasting Glucose 2.0 2.4 2.5 1.5 1.6
HbA1C 1.2 1.3 1.8 1.3 -0.9
HDL Cholesterol 0.2 0.4 0.7 0.8 -0.3
LDL Cholesterol 1.1 1.8 3.6 -1.9 -0.2
Lupus 0.5 0.7 1.4 0.2 1.2
Neuroticism (2016) 1.7 2.4 4.8 2.2 -0.2
Primary Biliary Cirrhosis 0.3 0.5 1.0 -1.0 0.1
Rheumatoid Arthritis 2.2 3.1 5.8 0.6 2.4
Schizophrenia (2014) 0.7 1.5 2.8 0.3 1.7
Triglycerides 0.3 0.6 0.9 -1.0 0.4
Type 2 Diabetes (T2D) (2012) 0.8 1.0 1.9 -1.4 0.1
Ulcerative Colitis 0.0 0.0 0.0 0.1 -0.1
Blood Eosinophil Count 0.8 6.1 12.0 -3.5 0.4
Blood Platelet Count 1.5 17.5 28.8 -5.4 2.5
Blood Red Count 0.2 2.1 2.5 1.3 1.6
Blood White Count 0.2 1.3 1.8 -0.9 -1.3
Heel T-Score 2.0 15.7 16.6 3.9 4.1
BMI 1.2 6.9 13.2 -3.6 -0.8
Height 1.9 36.3 67.1 8.2 -2.4
Waist Hip Ratio (WHR) 0.3 1.4 2.3 -1.5 -0.7
Systolic Blood Pressure 1.4 7.1 7.8 -2.8 2.5
Smoking Status 0.1 0.2 0.2 0.4 -0.4
Allergy or Eczema 0.1 0.2 0.4 0.6 -0.0
Cardiovascular Disease 1.4 4.6 6.6 -2.6 1.6
Hypothyroidism (self reported) 0.3 0.7 0.8 -0.9 0.7
Respiratory disease 0.1 0.1 0.3 0.5 -0.0
Type 2 Diabetes (T2D) (2018) 1.9 3.6 5.6 -1.3 -2.4
Lung FEV1/FVC ratio 1.1 5.3 10.5 -3.2 0.4
Lung FVC 0.8 4.3 8.5 2.9 0.2
Neuroticism 0.8 2.0 2.8 1.7 1.1
Chronotype (morning person) 1.1 2.6 3.9 2.0 1.1
Hair Pigment 0.2 5.2 6.5 2.5 -2.0
Tanning 0.0 0.1 0.2 -0.2 -0.5
Hand grip strength (left) 1.1 2.9 5.7 2.4 -0.3
Number of treatments/medications taken 1.9 3.4 5.1 -2.3 -1.3
Average weekly spirits intake 0.5 0.6 0.7 -0.7 0.8
Sensitivity / hurt feelings 0.4 0.7 1.3 1.1 0.4
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.1 -1.0 -0.6
Hearing difficulty/problems: Yes 0.2 0.2 0.4 -0.2 0.6
Relative age of first facial hair 3.1 6.4 10.2 3.2 -1.6
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 1.9 -1.4 -0.6
Ever used hormone-replacement therapy (HRT) 2.9 3.6 6.4 1.0 -2.5
Ever had hysterectomy (womb removed) 0.5 0.6 1.1 -0.3 -1.1
Systolic blood pressure, automated reading 0.4 1.2 1.6 -1.3 0.9
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.7 -0.8 -0.4
Angina 1.3 1.7 2.5 -0.9 -1.6
Medication for hormone replacement therapy 0.5 0.6 0.9 0.4 -1.0
Vitamin and mineral supplements 0.5 0.6 1.3 1.1 -0.1
Supplements: Zinc 0.3 0.4 0.4 0.6 -0.6
Medication: Co-codamol 0.6 0.7 1.4 -1.2 -0.1
Medication: Metformin 0.7 1.0 1.4 -1.2 -0.7
Diabetes (father) 0.6 0.7 1.0 -0.7 -1.0
Diabetes (mother) 1.6 2.0 3.1 -1.0 -1.8
Severe depression (siblings) 1.0 1.1 1.8 -0.6 -1.4
Pack years adult smoking proportion 0.1 0.1 0.2 0.3 -0.4
Impedance of leg (right) 0.3 1.3 2.5 0.5 -1.6
Leg fat-free mass (left) 0.1 0.6 0.9 1.0 -0.5
Trunk fat percentage 1.4 5.8 9.3 -3.0 -1.5
Hand grip strength (right) 1.8 5.0 9.4 3.1 -0.7
Townsend deprivation index at recruitment 0.7 1.0 1.2 -1.1 -0.9
Current tobacco smoking 2.5 4.0 8.0 -2.8 0.3
Average weekly fortified wine intake 3.3 3.9 4.5 -1.8 -2.1
Maternal smoking around birth 0.2 0.2 0.4 -0.7 0.2
Fed-up feelings 3.3 6.0 6.6 2.6 2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.4 0.3 1.2
Relative age voice broke 0.9 1.3 2.2 1.5 0.6
Taking other prescription medications 0.1 0.2 0.2 -0.5 -0.4
Age when periods started (menarche) 0.1 0.3 0.5 -0.7 -0.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.0 -0.8 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.0 5.6 2.4 0.7
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.5 1.9 0.4
Qualifications: CSEs or equivalent 0.9 1.1 1.1 -1.1 1.1
Serious illness, injury or assault to yourself 1.5 1.9 3.2 -0.7 -1.8
High blood pressure 0.7 1.9 2.7 -1.1 1.6
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.7 0.5 0.9
Multivitamins +/- minerals 0.2 0.2 0.4 -0.6 0.3
Stomach or abdominal pain in last month 0.2 0.3 0.4 -0.4 -0.6
Supplements: Glucosamine 0.8 1.1 1.2 1.1 0.9
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 2.0 -0.9 -1.4
Medication: Atenolol 2.4 3.0 4.6 -2.1 -1.1
Medication: Levothyroxine sodium 0.0 0.0 0.0 0.1 -0.0
Sitting height 3.4 24.0 47.7 6.9 0.5
Chronic bronchitis/emphysema (father) 6.6 7.7 15.0 0.7 -3.9
High blood pressure (mother) 1.2 1.7 3.1 -1.8 0.6
Body mass index (BMI) 0.6 2.7 5.0 -2.2 -0.6
Impedance of leg (left) 0.1 0.7 1.1 0.6 -1.1
Leg predicted mass (left) 0.1 0.6 0.9 1.0 -0.6
Trunk fat mass 0.7 3.0 3.5 -1.9 -1.6
Waist circumference 1.0 3.5 3.7 -1.8 -1.9
Number of incorrect matches in round 0.0 0.0 0.0 -0.2 -0.2
Past tobacco smoking 2.5 4.6 6.4 -2.5 1.7
Alcohol usually taken with meals 0.3 0.5 0.8 -0.5 0.9
Nervous feelings 2.6 4.8 7.3 1.5 2.7
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 0.8 0.9 0.8
Hearing difficulty/problems with background noise 0.1 0.1 0.1 0.3 -0.3
Hair/balding pattern: Pattern 2 1.2 1.5 2.6 1.6 -0.6
Had menopause 0.3 0.4 0.6 -0.5 -0.8
Had other major operations 2.6 3.1 4.8 -1.2 -2.2
Forced vital capacity (FVC) 1.2 4.6 9.2 3.0 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 3.5 1.9 1.3
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.5 1.2 0.5
Qualifications: None of the above 1.0 2.2 2.4 1.5 -1.4
Financial difficulties in last 2 years 0.6 0.8 1.5 -1.2 0.0
Mouth/teeth dental problems 0.3 0.5 0.5 -0.7 -0.7
Heart attack 1.1 1.4 2.7 -0.4 -1.6
Allergy 0.3 0.7 1.1 -1.0 -0.6
Pain all over the body in last month 0.4 0.4 0.9 0.9 -0.0
Diabetes (self-reported) 2.2 3.3 4.6 -1.4 -2.1
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.9 0.2 0.9
Medication: Ramipril 0.9 1.2 1.2 -1.1 1.0
Medication: Simvastatin 2.2 3.3 5.8 -0.9 -2.4
Fluid intelligence score 0.8 1.8 3.1 -1.8 0.6
Illnesses of siblings 0.2 0.3 0.5 -0.4 0.7
Neuroticism score 2.6 5.4 6.7 2.6 2.0
Weight 0.2 0.9 1.7 -0.1 -1.3
Impedance of arm (right) 0.6 2.6 4.2 -2.0 -1.0
Arm fat percentage (right) 2.1 8.5 15.3 -3.9 -1.3
Trunk fat-free mass 0.9 5.1 9.4 3.1 -0.9
Hip circumference 0.5 1.9 3.7 -0.4 -1.9
Time employed in main current job 2.1 2.4 4.9 -2.2 0.1
Alcohol intake versus 10 years previously 0.0 0.1 0.1 0.3 0.1
Father’s age at death 0.2 0.3 0.3 -0.5 0.5
Worrier / anxious feelings 2.2 4.1 7.3 1.0 2.7
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.2 -0.4 0.4
Falls in the last year 0.3 0.5 0.8 -0.9 0.3
Hair/balding pattern: Pattern 3 1.9 2.8 3.1 -1.6 1.8
Number of live births 0.2 0.3 0.4 -0.5 0.7
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 4.6 2.1 0.2
Pulse rate 0.5 0.9 1.8 1.3 0.1
Happiness 1.3 1.6 2.1 -1.0 1.4
Noisy workplace 0.4 0.5 1.0 0.2 -1.0
Qualifications: A levels/AS levels or equivalent 0.2 0.5 0.7 -0.9 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.7 -0.8 0.1
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 0.3 -0.5
Asthma 0.0 0.0 0.0 0.2 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.1 0.4 0.1
Medication: Cholesterol lowering 0.7 1.1 1.3 -1.1 -0.9
Depression (self-reported) 0.4 0.4 0.8 0.3 -0.9
Medication: Lansoprazole 0.3 0.3 0.6 0.8 0.1
Prospective memory result 0.5 0.6 0.9 0.9 -0.6
Lung cancer (father) 0.5 0.6 0.8 0.9 0.7
Illnesses of mother 0.3 0.4 0.6 0.8 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.7 4.5 2.1 0.9
Pulse wave Arterial Stiffness index 2.4 2.8 5.6 -0.2 -2.4
Impedance of arm (left) 0.7 3.3 4.2 -2.1 -1.5
Arm fat mass (right) 0.7 2.8 4.5 -2.1 -1.1
Trunk predicted mass 0.8 4.8 8.9 3.0 -0.8
Standing height 1.4 13.5 23.8 4.9 -1.8
Length of working week for main job 0.9 1.0 2.0 1.4 0.3
Exposure to tobacco smoke at home 0.1 0.1 0.2 0.3 -0.4
Breastfed as a baby 0.4 0.5 1.1 1.0 -0.0
Tense / ‘highly strung’ 2.2 3.7 4.1 2.0 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 2.2 1.5 -1.2
Hair/balding pattern: Pattern 4 0.9 2.1 2.2 -1.4 1.5
Birth weight of first child 0.2 0.4 0.4 -0.6 0.7
Peak expiratory flow (PEF) 1.9 4.4 7.3 2.7 -1.2
Pulse wave reflection index 0.9 1.1 1.5 -0.8 -1.2
Ever highly irritable/argumentative for 2 days 0.6 0.8 1.2 -0.6 1.1
Loud music exposure frequency 2.0 2.2 3.2 1.1 1.8
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.1 0.1 -0.2
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 1.5 -1.2 1.2
Blood clot in the leg (DVT) 0.5 0.7 1.1 1.0 -0.5
Medication: Paracetamol 0.9 1.4 2.3 -0.8 1.5
Headache pain in last month 0.3 0.5 0.7 -0.5 0.9
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.3 0.5 0.0
Glaucoma (self-reported) 1.3 1.6 2.8 0.6 -1.7
Gout (self-reported) 1.1 1.5 3.1 -1.8 -0.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.4 -0.6 0.3
Medication: Amlodipine 1.7 2.4 4.4 -2.1 0.7
Medication: Ventolin 100micrograms inhaler 0.9 1.1 2.2 -1.5 0.2
Birth weight 0.6 1.4 2.7 0.4 -1.6
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.2 -0.6 -1.1
High blood pressure (siblings) 0.2 0.3 0.6 0.8 -0.3
Forced vital capacity (FVC), Best measure 1.5 5.6 11.2 3.3 0.3
Body fat percentage 1.4 5.7 9.2 -3.0 -1.5
Leg fat percentage (right) 1.5 5.3 7.1 -2.7 -1.9
Arm fat-free mass (right) 0.9 4.5 8.4 2.9 -0.8
Exposure to tobacco smoke outside home 3.5 4.6 9.2 -3.0 0.3
Comparative body size at age 10 0.6 1.7 3.4 -1.8 -0.1
Number of full brothers 0.2 0.2 0.3 -0.6 -0.4
Worry too long after embarrassment 4.1 6.9 7.1 2.7 2.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.3 0.3 -1.1
Wheeze or whistling in the chest in last year 0.1 0.2 0.3 0.5 -0.2
Number of children fathered 0.6 0.6 1.1 1.0 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 3.4 1.8 0.5
Age at first live birth 2.0 3.5 5.8 -2.4 1.1
Pulse wave peak to peak time 2.2 2.6 4.9 0.6 2.2
Health satisfaction 0.3 0.4 0.8 -0.3 0.9
Shortness of breath walking on level ground 0.5 0.6 0.7 -0.8 0.7
Qualifications: College or University degree 0.6 1.7 2.6 -0.9 1.6
Eye problems/disorders: None of the above 2.9 3.3 4.5 2.1 1.4
Mouth/teeth dental problems: Loose teeth 1.0 1.1 1.7 1.3 0.8
Emphysema/chronic bronchitis 0.5 0.5 0.9 -0.4 0.9
Medication for pain relief, constipation, heartburn 1.6 2.7 5.5 2.3 -0.1
Neck or shoulder pain in last month 0.8 1.1 1.2 -1.1 1.1
Medication: Blood pressure 0.7 1.3 2.1 -1.4 0.7
Angina (self-reported) 1.4 1.9 2.6 -1.1 -1.6
Migraine (self-reported) 1.4 1.7 2.9 0.7 -1.7
Medication: Ibuprofen 0.1 0.2 0.2 -0.4 -0.4
Medication: Allopurinol 1.5 1.9 3.9 -2.0 0.0
Medication: Omeprazole 0.0 0.0 0.1 -0.1 0.3
Medication: Seretide 50 evohaler 0.8 0.9 1.7 0.4 -1.3
Mean time to correctly identify matches 1.3 2.4 4.5 -0.6 -2.1
Heart disease (mother) 0.8 0.9 1.3 -1.2 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.2 0.5 0.5
Whole body fat mass 0.6 2.4 3.2 -1.8 -1.2
Leg fat mass (right) 0.4 1.7 1.9 -1.4 -1.2
Arm predicted mass (right) 1.0 4.9 9.4 3.1 -0.6
Pulse rate, automated reading 0.5 1.7 3.4 1.9 -0.1
Alcohol intake frequency. 0.1 0.3 0.4 -0.6 -0.4
Comparative height size at age 10 0.4 2.0 4.0 2.0 -0.1
Number of full sisters 2.4 3.0 5.3 2.3 -0.8
Suffer from ‘nerves’ 0.6 0.9 1.6 0.4 1.3
Overall health rating 0.1 0.2 0.2 -0.3 -0.5
Chest pain or discomfort 0.1 0.1 0.2 -0.2 0.4
Had major operations 0.1 0.1 0.1 -0.4 0.3
Age at last live birth 1.4 2.0 2.3 -1.3 1.5
Family relationship satisfaction 0.4 0.4 0.7 -0.4 0.8
Leg pain on walking 2.3 2.9 5.3 -2.3 -0.7
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.6 0.0 1.6
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 -0.5 -0.1
Illness, injury, bereavement, stress in last 2 years 2.9 3.5 4.1 1.7 2.0
Medication: Aspirin 3.4 4.5 8.9 -3.0 -0.4
Supplements: Vitamin C 0.5 0.6 1.2 -1.1 -0.1
Knee pain experienced in last month 0.2 0.3 0.7 -0.8 0.1
Hypertension (Self-reported) 1.0 2.7 2.8 -1.6 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.5 2.8 -1.5 1.7
Illnesses of father: Heart disease 1.3 1.8 3.4 -1.8 -0.4
Illnesses of siblings: Diabetes 0.0 0.0 0.1 0.1 -0.2
Smoking status: Previous 3.3 5.0 7.0 2.6 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.0 1.0 0.3
Whole body fat-free mass 0.5 3.0 5.7 2.4 -0.5
Leg fat-free mass (right) 0.1 0.6 1.1 1.1 -0.1
Arm fat percentage (left) 2.2 8.7 15.3 -3.9 -1.5
Average weekly red wine intake 0.4 0.6 1.1 -1.0 -0.4
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.3 0.5 0.0
Mood swings 0.9 1.7 3.2 1.8 0.4
Loneliness, isolation 0.6 0.8 1.6 0.1 1.3
Long-standing illness, disability or infirmity 0.6 0.9 1.4 -1.2 -0.7
Ever had bowel cancer screening 0.7 0.9 1.7 1.3 0.0
Diabetes diagnosed by doctor 1.6 2.7 3.1 -1.5 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.3 -0.4
Friendships satisfaction 1.2 1.5 2.6 0.7 1.6
Qualifications: nursing, teaching 0.9 1.4 2.9 -0.1 -1.7
Commuting to job workplace: Walk 0.9 1.0 1.8 -1.4 0.4
Eye problems/disorders: Cataract 1.7 1.9 3.2 0.8 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 1.9 0.7 -1.4
Medication for cholesterol 1.9 2.9 4.0 2.0 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.1 0.3 -0.3
Back pain experienced in last month 0.6 0.9 1.2 -0.7 -1.1
Mineral and other dietary supplements 0.6 0.9 1.6 -1.3 -0.4
Breast cancer (self-reported) 0.1 0.1 0.1 -0.1 0.4
Asthma (self-reported) 0.0 0.1 0.1 0.4 -0.2
Osteoporosis (self-reported) 1.2 1.5 2.9 -0.2 -1.7
Osteoarthritis (self-reported) 0.7 1.0 1.8 -0.4 1.3
Medication: Aspirin 3.3 4.4 8.6 -2.9 -0.4
Medication: Gliclazide 0.1 0.2 0.2 -0.5 0.3
Illnesses of father: None of the above (group 1) 4.3 5.3 10.2 0.6 3.2
Smoking status: Current 2.0 3.2 6.2 -2.5 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 2.4 -0.8 1.6
Whole body water mass 0.5 3.0 5.8 2.4 -0.5
Leg predicted mass (right) 0.1 0.6 1.1 1.1 -0.1
Arm fat mass (left) 0.6 2.3 3.7 -1.9 -0.9
Number of self-reported non-cancer illnesses 0.6 1.0 1.4 -0.8 -1.2
Average weekly champagne plus white wine intake 0.1 0.1 0.1 0.2 -0.4
Miserableness 1.0 1.7 2.7 1.6 0.8
Guilty feelings 0.5 0.8 1.6 -0.2 1.2
Wears glasses or contact lenses 2.0 2.3 4.0 2.0 0.8
Ever taken oral contraceptive pill 0.2 0.2 0.4 0.3 -0.6
Hearing aid user 1.1 1.2 1.4 1.2 -1.0
Mother’s age at death 0.2 0.2 0.3 -0.4 0.6
Financial situation satisfaction 2.0 2.5 3.2 -1.8 1.4
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 -0.1 -0.6
Commuting to job workplace: Public transport 0.5 0.5 1.1 1.0 -0.0
Eye problems/disorders: Glaucoma 2.7 3.1 4.5 -1.3 -2.1
Medication: Blood pressure 0.9 1.7 3.0 -1.7 0.6
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.1 -0.5 -1.0
Supplements: Fish oil (including cod liver oil) 1.0 1.3 1.3 1.1 -1.1
High cholesterol (Self-reported) 1.2 2.1 2.6 -1.6 -1.3
Medication: Bendroflumethiazide 0.2 0.3 0.5 -0.3 0.7
Medication: Paracetamol 0.9 1.4 1.9 -0.9 1.4
Medication: Lisinopril 0.1 0.1 0.1 0.2 -0.4
Medication: Atorvastatin 3.3 4.1 6.8 -2.6 -1.2
Illnesses of father: High blood pressure 0.5 0.6 1.2 -1.1 -0.2
Alcohol drinker status: Never 0.5 0.7 0.8 0.7 -0.9
Ever smoked 1.6 2.7 4.2 1.1 -2.0
Basal metabolic rate 0.3 1.5 2.6 1.6 -0.6
Leg fat percentage (left) 1.4 5.2 7.5 -2.7 -1.7
Arm fat-free mass (left) 0.6 3.0 6.0 2.4 -0.3
Number of operations (self-reported) 1.8 2.7 4.2 -1.1 -2.0
Average weekly beer plus cider intake 1.3 1.8 3.0 -0.8 -1.7
Irritability 1.5 2.5 4.0 1.1 2.0
Risk taking 0.4 0.5 0.8 0.4 -0.9
Ever had prostate specific antigen (PSA) test 1.3 1.5 3.1 0.1 -1.8
Fractured/broken bones in last 5 years 2.9 3.7 4.2 -1.8 -2.0
Age started oral contraceptive pill 0.9 1.1 2.0 1.4 0.4
Diastolic blood pressure, automated reading 2.1 6.6 12.8 0.6 3.6
Ever depressed for a whole week 2.3 2.9 3.9 2.0 1.4
Unable to work because of sickness or disability 0.4 0.5 0.9 0.1 1.0
Commuting to job workplace: Cycle 1.3 1.6 2.3 -1.0 -1.5
Myopia 0.2 0.3 0.6 0.1 -0.8
Vascular/heart problems diagnosed by doctor 0.2 0.6 0.8 0.9 -0.7
Cholesterol lowering medication 2.9 4.2 4.4 -2.0 -2.1
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.3 -0.5 0.1
Pain experienced in last month 0.4 0.6 0.8 0.6 -0.9
Supplements: Calcium 2.2 2.4 4.4 2.1 -0.6
Basal cell carcinoma (self-reported) 0.4 0.5 0.6 -0.7 -0.7
Heart attack/myocardial infarction (self-reported) 1.3 1.7 3.3 -0.2 -1.8
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 0.8 0.9 -0.7
Heart disease (siblings) 0.1 0.1 0.2 0.2 -0.4
Alcohol drinker status: Previous 1.3 1.5 2.6 -0.7 1.6
Pack years of smoking 0.4 0.6 0.8 0.9 -0.6
Impedance of whole body 0.2 1.0 1.3 -0.9 -1.1
Leg fat mass (left) 0.4 1.6 2.0 -1.4 -1.1
Arm predicted mass (left) 0.8 3.8 7.5 2.7 -0.4