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chr17:71,991,083-74,629,867

Best TWAS P=2.46e-12 · Best GWAS P=1.74e-22 conditioned to 4.78e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	TRIM65	0.10	0.07	lasso	4	0.05	3.0e-05	-5.8	-6.2	5.9e-10	0.00	0.02	0.97	FALSE
2	GTEx	Adipose Subcutaneous	FBF1	0.36	0.29	lasso	2	0.29	5.4e-24	-6.1	-6.0	2.6e-09	0.00	0.02	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	FBF1	0.29	0.23	lasso	1	0.22	1.4e-11	-6.1	-6.1	8.2e-10	0.00	0.02	0.98	FALSE
4	GTEx	Artery Aorta	FBF1	0.32	0.27	lasso	2	0.26	2.2e-14	-6.1	-5.9	3.8e-09	0.00	0.02	0.98	FALSE
5	GTEx	Artery Tibial	FBF1	0.36	0.33	enet	12	0.33	3.7e-26	-6.1	-5.4	8.1e-08	0.01	0.02	0.98	FALSE
6	GTEx	Brain Cerebellar Hemisphere	CDR2L	0.31	0.00	enet	14	0.03	5.3e-02	2.5	5.2	1.8e-07	-0.46	0.04	0.13	FALSE
7	GTEx	Brain Hypothalamus	TRIM65	0.26	0.09	lasso	7	0.12	9.7e-04	-6.5	-5.3	1.1e-07	0.01	0.02	0.76	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	FBF1	0.29	0.32	lasso	2	0.29	1.9e-08	-5.8	-5.8	7.2e-09	0.00	0.05	0.92	FALSE
9	GTEx	Breast Mammary Tissue	FBF1	0.15	0.20	lasso	3	0.19	6.9e-10	-6.1	-6.2	6.3e-10	0.00	0.02	0.98	FALSE
10	GTEx	Breast Mammary Tissue (Female)	LLGL2	0.11	-0.01	lasso	1	0.03	6.0e-02	-6.5	6.5	7.5e-11	-0.04	0.02	0.48	TRUE
11	GTEx	Breast Mammary Tissue (Female)	FBF1	0.14	0.13	lasso	3	0.13	1.2e-04	-6.5	-5.8	7.8e-09	-0.01	0.01	0.92	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	TRIM47	0.42	0.07	lasso	4	0.06	4.0e-03	-5.5	-5.4	6.2e-08	-0.04	0.03	0.60	FALSE
13	GTEx	Cells Transformed fibroblasts	FBF1	0.14	0.08	lasso	5	0.07	5.1e-06	-6.1	-5.2	1.6e-07	-0.02	0.02	0.96	FALSE
14	GTEx	Colon Sigmoid	FBF1	0.38	0.10	enet	19	0.17	1.5e-06	-6.2	-5.2	1.9e-07	-0.02	0.03	0.97	FALSE
15	GTEx	Colon Transverse	TRIM65	0.32	0.13	lasso	6	0.12	3.1e-06	-6.1	-7.0	2.5e-12	0.02	0.03	0.97	TRUE
16	GTEx	Colon Transverse	FBF1	0.28	0.21	lasso	3	0.19	2.8e-09	-6.1	-5.8	9.1e-09	0.00	0.02	0.98	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	FBF1	0.33	0.16	lasso	6	0.13	2.3e-05	-5.8	-6.2	6.4e-10	0.01	0.04	0.94	FALSE
18	GTEx	Esophagus Muscularis	FBF1	0.34	0.33	lasso	3	0.32	5.5e-20	-6.1	-6.2	7.2e-10	0.01	0.02	0.98	FALSE
19	GTEx	Liver	GALK1	0.35	0.16	lasso	9	0.24	2.6e-07	-6.5	-5.9	3.5e-09	0.04	0.01	0.98	FALSE
20	GTEx	Lung	FBF1	0.20	0.18	lasso	1	0.17	2.6e-13	-6.1	-6.1	8.2e-10	0.00	0.02	0.98	FALSE
21	GTEx	Nerve Tibial	FBF1	0.54	0.46	enet	37	0.45	2.9e-35	-6.1	-5.3	9.9e-08	0.00	0.02	0.98	FALSE
22	GTEx	Pituitary	FBF1	0.34	0.37	lasso	4	0.39	7.6e-11	-6.1	-6.5	6.2e-11	0.01	0.02	0.97	FALSE
23	GTEx	Prostate	FBF1	0.26	0.24	lasso	1	0.20	1.2e-05	-6.1	-6.1	8.2e-10	0.00	0.02	0.96	FALSE
24	GTEx	Skin Sun Exposed Lower leg	TRIM65	0.19	0.00	enet	26	0.04	3.6e-04	4.2	-5.7	1.2e-08	0.02	0.02	0.92	FALSE
25	GTEx	Skin Sun Exposed Lower leg	FBF1	0.22	0.23	lasso	1	0.21	3.0e-17	-6.1	-6.1	8.2e-10	0.00	0.02	0.98	FALSE
26	GTEx	Stomach	FBF1	0.28	0.17	enet	12	0.17	1.5e-08	-6.1	-5.9	3.7e-09	0.02	0.02	0.98	FALSE
27	GTEx	Testis	TSEN54	0.50	0.34	enet	15	0.31	2.1e-14	-5.5	-6.1	1.0e-09	-0.01	0.40	0.60	TRUE
28	GTEx	Testis	FBF1	0.37	0.38	lasso	2	0.38	8.4e-18	-6.1	-6.1	1.3e-09	0.00	0.02	0.98	FALSE
29	GTEx	Thyroid	TRIM65	0.19	0.11	lasso	2	0.09	3.5e-07	-6.1	-6.2	7.0e-10	0.00	0.03	0.97	FALSE
30	GTEx	Thyroid	FBF1	0.24	0.23	lasso	2	0.23	8.0e-18	-6.1	-5.9	4.0e-09	0.00	0.02	0.98	FALSE
31	YFS	Blood	CD300LF	0.15	0.09	bslmm	440	0.12	2.3e-38	-2.1	6.7	2.9e-11	-0.72	0.98	0.02	TRUE
32	YFS	Blood	UNC13D	0.16	0.09	lasso	10	0.10	5.4e-30	4.2	6.3	2.5e-10	0.00	0.86	0.14	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FBF1	0.11	0.00	blup	41	0.00	1.9e-01	-1.4	-5.8	5.6e-09	0.02	0.01	0.20	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	CD300LF	0.05	0.02	blup	49	0.03	4.2e-04	-4.9	5.1	3.0e-07	-0.59	0.13	0.73	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRIM47	0.04	0.03	lasso	4	0.03	9.5e-04	-5.5	6.0	1.8e-09	0.01	0.02	0.71	FALSE
36	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRIM47	0.22	0.13	enet	7	0.17	1.7e-05	5.8	-6.0	2.2e-09	0.00	0.01	0.91	TRUE