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chr19:32,372,820-34,254,494

Best TWAS P=4.39e-16 · Best GWAS P=6.94e-16 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
40	GTEx	Thyroid	ANKRD27	0.15	0.01	enet	17	0.08	1.1e-06	7.8	-8.1	4.4e-16	-0.63	0.01	0.98	TRUE
26	GTEx	Heart Left Ventricle	PDCD5	0.18	0.01	enet	43	0.07	1.6e-04	1.8	6.5	5.6e-11	0.00	0.09	0.04	TRUE
44	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CEBPA	0.14	0.00	blup	39	0.07	1.6e-04	-0.8	6.5	7.9e-11	-0.04	0.01	0.21	TRUE
37	GTEx	Spleen	ANKRD27	0.43	0.06	enet	16	0.19	1.3e-05	-2.1	-6.0	2.1e-09	-0.50	0.06	0.80	TRUE
4	GTEx	Adrenal Gland	NUDT19	0.34	0.24	lasso	5	0.20	7.2e-08	5.4	-6.0	2.4e-09	-0.27	0.96	0.00	TRUE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NUDT19	0.13	0.08	blup	33	0.07	1.0e-04	5.4	-5.6	2.2e-08	-0.42	0.00	0.99	TRUE
2	GTEx	Adipose Subcutaneous	NUDT19	0.15	0.20	enet	6	0.20	6.6e-16	5.5	-5.5	3.6e-08	-0.31	1.00	0.00	TRUE
45	The Cancer Genome Atlas	Esophageal Carcinoma	PDCD5	0.25	-0.01	blup	59	0.05	1.2e-02	6.4	5.3	8.6e-08	0.31	0.01	0.13	TRUE
53	The Cancer Genome Atlas	Thyroid Carcinoma	ANKRD27	0.06	0.01	blup	77	0.03	5.1e-04	7.8	-7.9	3.3e-15	-0.68	0.02	0.93	FALSE
11	GTEx	Brain Frontal Cortex BA9	ANKRD27	0.35	0.41	lasso	9	0.37	9.3e-11	7.8	-7.9	3.9e-15	-0.93	0.01	0.99	FALSE
17	GTEx	Breast Mammary Tissue	ANKRD27	0.13	0.10	lasso	3	0.07	1.5e-04	7.8	-7.8	6.0e-15	-0.93	0.01	0.97	FALSE
29	GTEx	Muscle Skeletal	PDCD5	0.15	0.11	lasso	6	0.14	1.6e-13	-7.1	7.7	1.5e-14	0.21	0.79	0.21	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	ANKRD27	0.25	0.25	lasso	3	0.24	4.9e-07	7.8	-7.6	2.3e-14	-0.91	0.02	0.97	FALSE
52	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ANKRD27	0.18	0.01	lasso	11	0.03	2.5e-02	5.4	-7.6	2.4e-14	-0.62	0.01	0.45	FALSE
16	GTEx	Brain Putamen basal ganglia	ANKRD27	0.24	0.26	enet	16	0.18	3.9e-05	7.8	-7.5	5.0e-14	-0.87	0.02	0.96	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANKRD27	0.15	0.03	blup	77	0.08	1.8e-09	-3.2	-7.4	1.2e-13	-0.51	0.02	0.97	FALSE
7	GTEx	Artery Tibial	ANKRD27	0.47	0.19	enet	42	0.30	1.6e-23	-3.4	-7.3	2.9e-13	-0.45	0.99	0.01	FALSE
35	GTEx	Skin Sun Exposed Lower leg	ANKRD27	0.11	0.01	enet	16	0.02	1.4e-02	-6.1	-7.3	3.6e-13	-0.31	0.10	0.46	FALSE
1	GTEx	Adipose Subcutaneous	ANKRD27	0.23	0.02	enet	23	0.13	1.3e-10	-3.4	-7.2	6.9e-13	-0.53	0.06	0.91	FALSE
12	GTEx	Brain Frontal Cortex BA9	NUDT19	0.18	0.06	enet	25	0.12	5.0e-04	7.8	-7.0	3.6e-12	-0.63	0.03	0.89	FALSE
3	GTEx	Adipose Visceral Omentum	ANKRD27	0.16	0.02	lasso	7	0.06	2.8e-04	4.3	-6.8	8.1e-12	-0.77	0.03	0.96	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	ANKRD27	0.15	0.04	enet	8	0.09	2.7e-10	-3.4	-6.6	4.4e-11	-0.46	0.28	0.70	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC7A9	0.17	0.07	blup	59	0.13	1.1e-14	5.0	6.3	3.4e-10	0.23	0.01	0.99	FALSE
31	GTEx	Nerve Tibial	C19orf40	0.22	0.05	lasso	8	0.07	1.4e-05	4.0	-6.2	6.4e-10	-0.39	0.18	0.56	FALSE
20	GTEx	Cells Transformed fibroblasts	ANKRD27	0.21	0.08	lasso	6	0.08	7.0e-07	-3.4	-6.1	9.3e-10	-0.33	0.52	0.43	FALSE
13	GTEx	Brain Hippocampus	RHPN2	0.22	-0.01	enet	9	0.00	3.3e-01	-1.4	-6.1	1.2e-09	-0.50	0.04	0.41	FALSE
21	GTEx	Cells Transformed fibroblasts	NUDT19	0.25	0.25	lasso	4	0.26	1.5e-19	5.5	-6.1	1.3e-09	-0.32	1.00	0.00	FALSE
10	GTEx	Brain Cortex	ANKRD27	0.32	0.25	enet	23	0.28	1.6e-08	6.6	-6.0	2.0e-09	-0.76	0.05	0.93	FALSE
27	GTEx	Liver	NUDT19	0.42	0.25	lasso	9	0.25	1.2e-07	5.3	-6.0	2.0e-09	-0.30	0.68	0.03	FALSE
32	GTEx	Nerve Tibial	NUDT19	0.23	0.19	enet	20	0.18	3.8e-13	5.5	-5.9	3.4e-09	-0.27	1.00	0.00	FALSE
8	GTEx	Brain Caudate basal ganglia	ANKRD27	0.24	0.17	enet	12	0.21	1.0e-06	6.5	-5.9	3.5e-09	-0.85	0.07	0.91	FALSE
24	GTEx	Esophagus Muscularis	ANKRD27	0.28	0.02	lasso	12	0.06	9.5e-05	-3.2	-5.9	3.8e-09	-0.46	0.04	0.88	FALSE
22	GTEx	Colon Transverse	NUDT19	0.46	0.25	enet	14	0.26	1.1e-12	4.7	-5.9	3.9e-09	-0.26	1.00	0.00	FALSE
30	GTEx	Muscle Skeletal	NUDT19	0.17	0.15	lasso	5	0.15	1.2e-14	5.4	-5.7	9.2e-09	-0.30	1.00	0.00	FALSE
41	GTEx	Thyroid	NUDT19	0.20	0.19	lasso	4	0.20	3.5e-15	5.5	-5.7	1.2e-08	-0.30	1.00	0.00	FALSE
42	NTR	Blood	ANKRD27	0.07	0.08	bslmm	425	0.08	2.0e-25	7.8	5.7	1.3e-08	0.91	0.01	0.99	FALSE
39	GTEx	Testis	NUDT19	0.28	0.28	lasso	4	0.26	7.7e-12	5.3	-5.6	2.2e-08	-0.33	1.00	0.00	FALSE
5	GTEx	Artery Aorta	ANKRD27	0.23	0.05	enet	33	0.06	2.6e-04	-3.4	-5.6	2.5e-08	-0.37	0.08	0.86	FALSE
9	GTEx	Brain Caudate basal ganglia	RHPN2	0.20	-0.01	enet	18	0.03	4.8e-02	1.3	-5.5	3.0e-08	-0.51	0.07	0.21	FALSE
18	GTEx	Breast Mammary Tissue	C19orf40	0.23	0.00	enet	14	0.04	4.1e-03	-1.6	-5.5	3.0e-08	-0.32	0.17	0.19	FALSE
38	GTEx	Spleen	NUDT19	0.49	0.47	lasso	3	0.43	2.2e-12	5.5	-5.5	3.2e-08	-0.31	0.98	0.02	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	NUDT19	0.03	0.03	lasso	1	0.03	6.4e-05	5.5	-5.5	3.2e-08	-0.31	0.00	0.99	FALSE
33	GTEx	Pancreas	NUDT19	0.15	0.15	lasso	4	0.13	5.9e-06	5.5	-5.5	3.4e-08	-0.32	0.66	0.05	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NUDT19	0.10	0.09	lasso	2	0.10	2.3e-11	5.5	-5.4	5.3e-08	-0.31	0.00	1.00	FALSE
25	GTEx	Heart Atrial Appendage	NUDT19	0.29	0.21	lasso	5	0.21	6.3e-10	5.4	-5.3	8.6e-08	-0.31	1.00	0.00	FALSE
36	GTEx	Skin Sun Exposed Lower leg	NUDT19	0.22	0.24	enet	7	0.26	1.2e-21	5.5	-5.3	9.3e-08	-0.31	1.00	0.00	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	NUDT19	0.22	0.28	lasso	3	0.26	7.5e-10	5.4	-5.3	1.1e-07	-0.31	0.99	0.01	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	NUDT19	0.15	0.11	lasso	3	0.12	3.1e-07	5.4	-5.3	1.1e-07	-0.31	0.97	0.00	FALSE
19	GTEx	Breast Mammary Tissue	NUDT19	0.16	0.14	lasso	8	0.09	2.5e-05	5.5	-5.3	1.4e-07	-0.28	0.88	0.02	FALSE
14	GTEx	Brain Hippocampus	NUDT19	0.24	0.06	enet	16	0.13	5.9e-04	4.7	-5.3	1.5e-07	-0.62	0.05	0.74	FALSE
43	YFS	Blood	PDCD5	0.11	0.04	bslmm	389	0.09	8.3e-27	-7.1	5.2	1.9e-07	0.12	0.86	0.14	FALSE
6	GTEx	Artery Coronary	NUDT19	0.30	0.22	lasso	5	0.20	2.0e-07	5.4	-5.2	2.1e-07	-0.35	0.87	0.03	FALSE
28	GTEx	Lung	NUDT19	0.22	0.23	lasso	5	0.23	1.0e-17	5.4	-5.2	2.4e-07	-0.31	1.00	0.00	FALSE