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chr19:16,462,417-20,934,630

Best TWAS P=2.77e-43 · Best GWAS P=1.47e-45 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
59	YFS	Blood	GATAD2A	0.09	0.14	blup	365	0.14	7.5e-44	13.58	13.8	2.8e-43	0.34	0.88	0.12	TRUE
70	The Cancer Genome Atlas	Colon Adenocarcinoma	GATAD2A	0.04	0.03	blup	61	0.05	1.3e-03	13.04	13.1	3.2e-39	0.20	0.03	0.83	TRUE
52	ROSMAP	Brain Pre-frontal Cortex	ATP13A1	0.10	0.07	lasso	5	0.06	1.3e-08	14.17	-12.9	3.2e-38	-0.97	0.00	1.00	TRUE
57	ROSMAP	Brain Pre-frontal Cortex	HAPLN4	0.05	0.03	enet	15	0.03	1.7e-04	9.34	10.2	2.7e-24	0.01	0.97	0.01	TRUE
19	GTEx	Colon Transverse	YJEFN3	0.09	0.09	lasso	3	0.07	4.3e-04	9.86	-9.7	2.7e-22	0.08	0.40	0.04	TRUE
22	GTEx	Esophagus Muscularis	MYO9B	0.13	0.02	lasso	5	0.05	9.5e-04	6.76	-9.4	3.2e-21	0.00	0.04	0.94	TRUE
61	YFS	Blood	HAUS8	0.03	0.02	lasso	6	0.02	3.3e-07	8.08	-9.1	8.4e-20	0.03	1.00	0.00	TRUE
92	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HAUS8	0.21	0.11	enet	9	0.10	6.2e-05	-10.48	-7.3	2.2e-13	0.04	0.14	0.27	TRUE
32	GTEx	Nerve Tibial	FCHO1	0.21	0.04	enet	13	0.06	2.3e-05	5.12	-7.3	3.3e-13	0.00	0.02	0.92	TRUE
13	GTEx	Brain Hippocampus	DDX49	0.23	-0.01	lasso	4	-0.01	6.6e-01	6.65	-6.8	1.4e-11	-0.46	0.04	0.22	TRUE
6	GTEx	Artery Tibial	ZNF14	0.15	0.10	enet	13	0.10	5.5e-08	4.52	-6.4	1.3e-10	-0.06	0.96	0.00	TRUE
102	The Cancer Genome Atlas	Thyroid Carcinoma	HAUS8	0.04	0.06	lasso	2	0.05	2.2e-05	6.62	-5.9	2.8e-09	0.02	0.76	0.02	TRUE
37	GTEx	Thyroid	ZNF90	0.15	0.07	lasso	6	0.07	7.0e-06	6.43	5.9	3.1e-09	0.08	0.97	0.00	TRUE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	GMIP	0.07	0.04	blup	43	0.04	8.5e-06	2.55	5.4	8.2e-08	-0.10	0.84	0.00	TRUE
79	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST3	0.04	0.02	blup	65	0.01	7.3e-02	-3.64	5.3	1.1e-07	-0.01	0.01	0.43	TRUE
40	GTEx	Whole Blood	TMEM161A	0.06	0.00	enet	2	0.00	1.4e-01	13.48	-13.5	1.8e-41	-0.33	0.03	0.84	FALSE
73	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GATAD2A	0.02	0.02	lasso	1	0.02	2.1e-03	13.47	13.5	2.5e-41	0.34	0.02	0.80	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GATAD2A	0.13	0.30	lasso	7	0.29	2.4e-35	13.51	-13.4	5.5e-41	-0.31	0.90	0.10	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA0892	0.04	0.04	blup	43	0.02	4.1e-03	12.33	-12.9	2.5e-38	-0.35	0.05	0.90	FALSE
85	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSSK6	0.02	0.02	blup	33	0.02	1.8e-03	13.47	12.8	1.5e-37	0.16	0.01	0.84	FALSE
18	GTEx	Cells Transformed fibroblasts	GATAD2A	0.07	0.00	lasso	4	0.00	8.1e-01	13.48	12.7	6.3e-37	0.64	0.09	0.11	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	HAPLN4	0.08	0.06	blup	37	0.09	1.8e-09	12.45	12.6	2.4e-36	0.28	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	GATAD2A	0.04	0.03	lasso	2	0.03	2.9e-04	13.41	12.5	8.8e-36	0.43	0.02	0.94	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA0892	0.03	0.01	lasso	7	0.02	6.3e-03	12.33	-12.4	2.5e-35	-0.34	0.03	0.61	FALSE
43	GTEx	Whole Blood	GATAD2A	0.06	0.02	lasso	9	0.03	1.7e-03	13.17	12.3	6.0e-35	0.52	0.29	0.62	FALSE
77	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAPLN4	0.05	0.07	lasso	2	0.06	1.1e-07	12.33	12.1	1.5e-33	0.39	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	YJEFN3	0.04	0.05	lasso	7	0.04	1.6e-04	9.77	-11.9	1.3e-32	-0.06	0.07	0.78	FALSE
47	NTR	Blood	GATAD2A	0.02	0.02	blup	386	0.02	1.4e-07	12.94	11.7	2.0e-31	0.29	0.93	0.07	FALSE
36	GTEx	Spleen	ATP13A1	0.16	0.01	lasso	5	0.02	9.7e-02	13.52	11.6	2.5e-31	0.26	0.07	0.15	FALSE
7	GTEx	Artery Tibial	MAU2	0.07	0.05	lasso	4	0.05	1.3e-04	12.94	11.6	4.0e-31	0.33	0.51	0.12	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	HAPLN4	0.10	0.08	blup	38	0.11	8.5e-07	12.35	11.5	1.0e-30	0.17	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAPLN4	0.07	0.05	lasso	7	0.07	2.9e-08	9.17	11.5	1.9e-30	0.12	0.05	0.95	FALSE
27	GTEx	Muscle Skeletal	SUGP1	0.11	0.06	lasso	7	0.07	9.5e-08	9.28	-11.4	4.2e-30	-0.09	1.00	0.00	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GMIP	0.03	0.02	lasso	4	0.02	3.2e-03	9.14	11.4	4.7e-30	0.10	0.06	0.04	FALSE
97	The Cancer Genome Atlas	Soft Tissue Sarcoma	HAPLN4	0.11	0.01	blup	38	0.02	2.7e-02	9.17	11.4	5.6e-30	0.08	0.02	0.68	FALSE
14	GTEx	Cells Transformed fibroblasts	LPAR2	0.04	0.05	lasso	2	0.04	5.5e-04	9.14	-11.3	1.6e-29	-0.04	0.25	0.06	FALSE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SF4	0.03	0.01	enet	7	0.02	1.1e-03	13.34	11.2	3.0e-29	0.31	0.01	0.97	FALSE
28	GTEx	Muscle Skeletal	MAU2	0.09	0.04	lasso	4	0.05	5.1e-06	6.80	-11.1	9.6e-29	-0.48	0.97	0.03	FALSE
38	GTEx	Thyroid	YJEFN3	0.05	0.02	lasso	3	0.02	1.2e-02	9.63	-11.0	5.4e-28	-0.09	0.24	0.03	FALSE
10	GTEx	Brain Cerebellum	SUGP2	0.15	-0.01	enet	27	0.00	2.3e-01	9.34	10.9	1.5e-27	0.13	0.03	0.64	FALSE
11	GTEx	Brain Cerebellum	ARMC6	0.28	0.00	enet	43	0.13	1.5e-04	-2.80	10.9	1.6e-27	0.24	0.04	0.66	FALSE
90	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMIP	0.07	0.00	blup	43	0.02	2.3e-02	13.62	10.9	1.7e-27	0.39	0.03	0.05	FALSE
65	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAPLN4	0.04	0.07	lasso	4	0.06	1.3e-12	9.26	10.7	5.9e-27	0.06	0.96	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HAPLN4	0.07	0.10	lasso	6	0.10	5.3e-12	9.28	10.4	2.0e-25	0.02	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	CILP2	0.02	0.02	blup	30	0.02	1.6e-04	9.84	10.2	1.2e-24	0.01	0.16	0.25	FALSE
12	GTEx	Brain Cerebellum	PBX4	0.20	0.09	lasso	6	0.13	9.9e-05	13.62	10.2	1.6e-24	0.14	0.27	0.06	FALSE
60	YFS	Blood	GMIP	0.10	0.06	enet	37	0.08	9.6e-24	-6.26	10.2	2.1e-24	0.12	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MAU2	0.09	0.08	blup	369	0.10	1.0e-12	12.94	-9.9	3.9e-23	-0.35	0.99	0.01	FALSE
48	NTR	Blood	LPAR2	0.04	0.03	lasso	3	0.03	3.6e-11	9.14	-9.9	4.9e-23	0.04	1.00	0.00	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	YJEFN3	0.04	0.05	lasso	2	0.05	4.3e-06	9.78	-9.8	1.4e-22	0.05	0.63	0.22	FALSE
62	YFS	Blood	LPAR2	0.14	0.15	lasso	5	0.16	3.6e-48	9.16	-9.6	1.2e-21	0.08	1.00	0.00	FALSE
15	GTEx	Cells Transformed fibroblasts	ATP13A1	0.14	0.06	lasso	5	0.05	2.2e-04	8.80	9.5	1.5e-21	0.75	0.10	0.76	FALSE
75	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAUS8	0.08	0.07	blup	55	0.07	6.7e-08	6.66	-9.2	2.3e-20	0.05	0.96	0.04	FALSE
94	The Cancer Genome Atlas	Prostate Adenocarcinoma	HAUS8	0.13	0.10	blup	55	0.11	7.8e-12	6.66	-9.2	5.6e-20	0.04	1.00	0.00	FALSE
46	NTR	Blood	ATP13A1	0.01	0.01	blup	339	0.01	1.9e-04	0.83	9.1	1.3e-19	0.37	0.06	0.36	FALSE
8	GTEx	Artery Tibial	HAUS8	0.16	0.02	lasso	7	0.02	4.7e-03	6.66	-9.0	2.5e-19	0.02	0.08	0.90	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	TSSK6	0.04	0.00	blup	346	0.01	1.1e-02	9.14	8.9	5.1e-19	-0.05	0.37	0.04	FALSE
99	The Cancer Genome Atlas	Stomach Adenocarcinoma	HAPLN4	0.08	0.03	blup	37	0.04	7.2e-04	9.38	8.8	1.0e-18	0.08	0.15	0.63	FALSE
25	GTEx	Lung	LPAR2	0.07	0.09	lasso	3	0.05	9.9e-05	9.14	-8.6	6.2e-18	0.15	0.86	0.04	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAUS8	0.05	0.06	enet	12	0.06	2.9e-12	6.62	-8.4	5.0e-17	0.00	1.00	0.00	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	ZNF14	0.11	0.08	bslmm	292	0.07	1.8e-09	2.93	8.1	5.7e-16	0.19	1.00	0.00	FALSE
30	GTEx	Nerve Tibial	LPAR2	0.14	0.05	lasso	5	0.06	2.3e-05	9.14	-8.0	1.2e-15	0.17	0.66	0.10	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	SUGP1	0.03	0.00	blup	364	0.01	4.3e-02	6.65	7.8	9.3e-15	0.42	0.12	0.05	FALSE
29	GTEx	Muscle Skeletal	HAUS8	0.15	0.10	lasso	4	0.08	1.6e-08	6.62	-7.8	9.5e-15	0.02	1.00	0.00	FALSE
41	GTEx	Whole Blood	LPAR2	0.10	0.07	lasso	5	0.07	8.0e-07	9.14	-7.7	2.0e-14	0.25	0.91	0.06	FALSE
72	The Cancer Genome Atlas	Colon Adenocarcinoma	HAUS8	0.12	0.06	lasso	5	0.06	1.8e-04	6.66	-7.6	3.5e-14	0.01	0.44	0.23	FALSE
44	METSIM	Adipose	CILP2	0.04	0.03	lasso	5	0.07	2.7e-11	12.77	7.4	9.8e-14	0.20	0.88	0.05	FALSE
35	GTEx	Spleen	LPAR2	0.27	0.06	lasso	6	0.04	2.7e-02	4.79	-7.4	1.3e-13	0.20	0.10	0.25	FALSE
86	The Cancer Genome Atlas	Lung Adenocarcinoma	HAUS8	0.04	0.04	lasso	2	0.03	1.6e-04	6.66	-7.3	3.3e-13	0.03	0.58	0.01	FALSE
33	GTEx	Skin Sun Exposed Lower leg	ZNF14	0.08	0.01	enet	12	0.02	4.5e-03	8.03	-7.3	3.7e-13	-0.22	0.48	0.02	FALSE
9	GTEx	Brain Cerebellar Hemisphere	HAUS8	0.44	0.15	lasso	7	0.11	8.1e-04	6.62	-7.2	5.2e-13	0.00	0.25	0.14	FALSE
89	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HAUS8	0.06	0.04	enet	4	0.05	3.9e-06	6.76	-7.2	5.4e-13	0.01	0.92	0.00	FALSE
81	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TM6SF2	0.04	0.03	blup	35	0.03	2.5e-04	6.35	6.9	4.2e-12	0.57	0.31	0.22	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF14	0.03	0.02	lasso	2	0.02	2.1e-05	-6.39	-6.9	4.7e-12	-0.12	0.58	0.01	FALSE
91	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HAUS8	0.20	0.13	lasso	2	0.11	2.4e-05	6.62	-6.9	5.9e-12	0.03	0.49	0.07	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	TM6SF2	0.05	0.04	blup	34	0.05	2.8e-05	6.35	6.8	8.4e-12	0.55	0.45	0.30	FALSE
21	GTEx	Esophagus Mucosa	GATAD2A	0.11	0.02	lasso	3	0.02	2.3e-02	7.38	6.8	8.7e-12	0.48	0.10	0.29	FALSE
39	GTEx	Vagina	CTC-559E9.5	0.25	0.08	lasso	2	0.09	5.0e-03	8.15	-6.8	9.3e-12	-0.31	0.04	0.05	FALSE
105	The Cancer Genome Atlas	Thyroid Carcinoma	YJEFN3	0.08	0.06	blup	33	0.08	7.1e-08	9.78	-6.8	1.0e-11	0.23	0.89	0.10	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	HAUS8	0.05	0.05	enet	7	0.05	7.1e-07	6.63	-6.8	1.2e-11	0.02	0.98	0.00	FALSE
88	The Cancer Genome Atlas	Lung Adenocarcinoma	YJEFN3	0.03	0.03	blup	32	0.02	3.0e-03	9.86	-6.6	3.5e-11	0.24	0.10	0.10	FALSE
24	GTEx	Heart Atrial Appendage	TMEM161A	0.29	0.10	enet	19	0.23	1.3e-10	4.17	6.6	3.8e-11	0.33	0.66	0.02	FALSE
45	METSIM	Adipose	FCHO1	0.05	0.03	lasso	3	0.04	2.1e-06	5.12	-6.5	5.6e-11	0.04	0.04	0.96	FALSE
42	GTEx	Whole Blood	FCHO1	0.15	0.11	lasso	3	0.09	9.6e-09	-6.48	6.5	1.1e-10	-0.02	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	HAUS8	0.11	0.09	lasso	3	0.08	5.4e-07	6.62	-6.5	1.2e-10	0.02	0.87	0.11	FALSE
23	GTEx	Esophagus Muscularis	HAUS8	0.20	0.11	lasso	4	0.09	5.1e-06	6.62	-6.4	1.2e-10	0.03	0.67	0.15	FALSE
26	GTEx	Lung	MAP1S	0.12	0.09	enet	6	0.09	4.2e-07	-6.05	-6.3	2.3e-10	0.03	0.01	0.99	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	MYO9B	0.11	0.01	lasso	8	0.07	5.4e-09	0.41	-6.3	2.8e-10	-0.06	0.23	0.74	FALSE
16	GTEx	Cells Transformed fibroblasts	MAP1S	0.24	0.18	enet	24	0.14	4.9e-11	-6.05	-6.3	3.1e-10	0.03	0.01	0.99	FALSE
31	GTEx	Nerve Tibial	ZNF14	0.06	0.03	lasso	3	0.02	8.2e-03	8.09	-6.3	3.9e-10	-0.17	0.26	0.04	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAUS8	0.09	0.14	lasso	4	0.12	5.9e-14	6.62	-6.2	4.0e-10	0.04	1.00	0.00	FALSE
5	GTEx	Artery Aorta	HAUS8	0.18	0.12	lasso	2	0.09	7.3e-06	6.66	-6.2	4.8e-10	0.03	0.86	0.01	FALSE
58	YFS	Blood	FCHO1	0.10	0.07	bslmm	439	0.07	2.0e-21	4.87	-6.1	1.2e-09	0.01	0.98	0.02	FALSE
17	GTEx	Cells Transformed fibroblasts	HAUS8	0.12	0.05	enet	19	0.05	1.0e-04	6.66	-6.0	1.7e-09	-0.01	0.40	0.48	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	MAU2	0.17	0.05	bslmm	362	0.06	8.0e-08	2.77	-6.0	1.9e-09	-0.15	0.84	0.01	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	MAP1S	0.02	0.00	blup	45	0.01	4.7e-03	6.34	-5.9	3.0e-09	-0.01	0.02	0.68	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	YJEFN3	0.03	0.02	enet	18	0.02	2.1e-04	9.80	-5.8	5.9e-09	0.24	0.26	0.16	FALSE
87	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC25A42	0.04	0.04	blup	55	0.04	2.2e-05	4.18	5.8	7.0e-09	0.11	0.33	0.65	FALSE
98	The Cancer Genome Atlas	Skin Cutaneous Melanoma	MAP1S	0.16	0.10	lasso	1	0.05	1.6e-02	-5.65	-5.7	1.6e-08	-0.02	0.01	0.49	FALSE
34	GTEx	Skin Sun Exposed Lower leg	MAP1S	0.14	0.10	lasso	2	0.07	1.7e-06	-6.05	-5.6	1.7e-08	0.03	0.03	0.97	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	ABHD8	0.13	0.05	blup	425	0.05	1.3e-07	1.52	-5.6	2.8e-08	-0.12	0.93	0.00	FALSE
100	The Cancer Genome Atlas	Stomach Adenocarcinoma	HAUS8	0.06	0.04	blup	55	0.04	1.0e-03	6.62	-5.5	3.5e-08	0.06	0.07	0.06	FALSE
82	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GMIP	0.07	0.02	enet	6	0.04	1.9e-03	2.05	5.5	3.8e-08	-0.18	0.05	0.04	FALSE
95	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYO9B	0.14	0.07	blup	103	0.10	5.0e-11	-1.79	-5.3	1.1e-07	-0.10	0.34	0.66	FALSE
20	GTEx	Esophagus Mucosa	LPAR2	0.08	0.03	lasso	2	0.01	1.1e-01	4.88	-5.2	2.4e-07	0.10	0.33	0.03	FALSE