Best TWAS P=1.41e-15 · Best GWAS P=2.13e-22 conditioned to 1.17e-23
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | RP3-511B24.6 | 0.21 | 0.00 | lasso | 5 | 0.00 | 2.5e-01 | 5.4 | -6.5 | 7.2e-11 | 0.08 | 0.05 | 0.22 | TRUE |
| 2 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EMILIN3 | 0.08 | 0.06 | lasso | 5 | 0.08 | 2.7e-09 | 7.3 | 7.0 | 2.0e-12 | -0.08 | 0.04 | 0.96 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZHX3 | 0.04 | 0.02 | lasso | 2 | 0.02 | 2.4e-03 | 5.7 | 5.2 | 2.3e-07 | -0.07 | 0.03 | 0.04 | FALSE |
| 4 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LPIN3 | 0.10 | 0.02 | lasso | 5 | 0.07 | 6.1e-04 | 7.6 | 8.0 | 1.4e-15 | 0.02 | 0.00 | 0.76 | TRUE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZHX3 | 0.05 | 0.06 | lasso | 2 | 0.05 | 2.6e-06 | 6.1 | -5.9 | 3.0e-09 | 0.02 | 0.23 | 0.76 | FALSE |