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chr20:42,495,338-45,835,008

Best TWAS P=9.41e-12 · Best GWAS P=6.95e-15 conditioned to 3.74e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adrenal Gland	STK4	0.25	0.20	lasso	5	0.17	1.1e-06	6.56	6.8	9.4e-12	0.00	0.03	0.97	TRUE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNX21	0.08	0.01	lasso	4	0.03	1.1e-04	5.90	-6.7	2.4e-11	-0.07	0.05	0.84	TRUE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	WFDC13	0.06	0.02	lasso	4	0.03	1.0e-04	4.86	6.3	3.4e-10	0.01	0.06	0.93	TRUE
42	The Cancer Genome Atlas	Thyroid Carcinoma	JPH2	0.10	0.05	blup	127	0.07	3.6e-07	-4.25	-6.1	9.3e-10	0.73	0.00	1.00	TRUE
6	GTEx	Breast Mammary Tissue (Male)	ZNF334	0.36	0.08	enet	17	0.21	1.3e-05	4.10	5.6	1.8e-08	0.01	0.01	0.79	TRUE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	STK4	0.09	0.08	lasso	2	0.07	3.9e-08	6.49	6.7	1.9e-11	-0.01	0.03	0.97	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	STK4	0.04	0.05	lasso	4	0.02	2.3e-02	6.54	6.5	6.1e-11	-0.01	0.03	0.79	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	STK4	0.04	0.03	blup	88	0.03	7.1e-05	6.49	6.1	1.1e-09	0.04	0.03	0.96	FALSE
12	METSIM	Adipose	PIGT	0.03	0.00	enet	23	0.01	6.8e-03	0.64	6.0	1.6e-09	0.05	0.08	0.24	FALSE
3	GTEx	Artery Coronary	DNTTIP1	0.38	0.22	lasso	8	0.16	6.7e-06	5.47	-5.9	2.9e-09	-0.01	0.16	0.83	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	STK4	0.06	0.01	blup	88	0.02	4.9e-03	-3.96	5.9	3.0e-09	-0.03	0.04	0.73	FALSE
17	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	WFDC3	0.22	0.30	lasso	4	0.31	8.8e-16	5.92	-5.9	4.7e-09	0.02	0.84	0.16	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	JPH2	0.08	0.01	blup	127	0.06	1.6e-07	-7.79	-5.8	5.1e-09	0.62	0.00	0.99	FALSE
8	GTEx	Muscle Skeletal	DNTTIP1	0.09	0.08	lasso	4	0.08	1.5e-08	5.92	-5.8	6.3e-09	0.02	0.68	0.32	FALSE
40	The Cancer Genome Atlas	Skin Cutaneous Melanoma	WFDC3	0.21	0.21	lasso	1	0.17	2.8e-05	5.75	-5.8	8.9e-09	0.02	0.16	0.54	FALSE
5	GTEx	Breast Mammary Tissue (Male)	DNTTIP1	0.24	-0.01	enet	2	-0.01	7.2e-01	5.73	-5.7	9.3e-09	0.02	0.06	0.11	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	WFDC3	0.32	0.54	lasso	8	0.54	4.1e-82	5.71	-5.7	1.0e-08	0.02	0.89	0.11	FALSE
35	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	WFDC3	0.23	0.38	lasso	2	0.37	2.2e-26	5.73	-5.7	1.0e-08	0.02	0.85	0.15	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	WFDC3	0.45	0.57	lasso	9	0.58	1.5e-73	5.75	-5.7	1.0e-08	0.02	0.87	0.13	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	WFDC3	0.17	0.39	lasso	5	0.38	7.7e-46	5.75	-5.7	1.1e-08	0.01	0.88	0.12	FALSE
4	GTEx	Artery Tibial	DNTTIP1	0.18	0.17	lasso	5	0.18	7.4e-14	5.88	-5.7	1.2e-08	0.00	0.82	0.18	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	WFDC3	0.20	0.38	lasso	4	0.38	4.9e-47	5.71	-5.7	1.2e-08	0.01	0.89	0.11	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	WFDC13	0.06	0.05	enet	3	0.04	2.7e-03	4.55	5.7	1.5e-08	0.02	0.03	0.58	FALSE
39	The Cancer Genome Atlas	Soft Tissue Sarcoma	WFDC3	0.27	0.37	lasso	5	0.36	1.5e-22	5.71	-5.7	1.5e-08	0.01	0.89	0.11	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	WFDC3	0.36	0.56	lasso	9	0.57	4.3e-68	5.71	-5.7	1.5e-08	0.01	0.89	0.11	FALSE
1	GTEx	Adipose Visceral Omentum	DNTTIP1	0.14	0.15	enet	9	0.13	2.0e-07	5.90	-5.6	1.7e-08	0.00	0.34	0.66	FALSE
10	GTEx	Whole Blood	DNTTIP1	0.06	0.07	lasso	2	0.05	1.1e-05	5.73	-5.6	1.8e-08	0.02	0.74	0.26	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WFDC3	0.27	0.41	lasso	6	0.42	5.7e-51	5.71	-5.6	1.8e-08	0.01	0.89	0.11	FALSE
9	GTEx	Nerve Tibial	DNTTIP1	0.13	0.13	enet	20	0.10	1.7e-07	5.75	-5.6	1.9e-08	0.02	0.82	0.18	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	WFDC3	0.17	0.38	lasso	11	0.38	6.9e-45	5.75	-5.6	1.9e-08	0.01	0.89	0.11	FALSE
16	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	WFDC3	0.16	0.30	lasso	7	0.28	4.1e-24	5.71	-5.6	2.3e-08	0.00	0.86	0.14	FALSE
22	The Cancer Genome Atlas	Glioblastoma Multiforme	WFDC3	0.38	0.38	enet	14	0.41	9.1e-14	5.73	-5.5	2.8e-08	0.01	0.08	0.92	FALSE
11	METSIM	Adipose	DNTTIP1	0.04	0.03	enet	12	0.02	2.0e-04	5.75	-5.5	3.7e-08	0.01	0.54	0.42	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	WFDC3	0.41	0.53	lasso	6	0.53	1.3e-35	5.71	-5.4	6.4e-08	0.02	0.89	0.11	FALSE
15	YFS	Blood	DNTTIP1	0.11	0.17	lasso	10	0.17	4.3e-54	5.75	-5.4	7.3e-08	0.01	0.84	0.16	FALSE
21	The Cancer Genome Atlas	Esophageal Carcinoma	WFDC3	0.24	0.26	blup	59	0.29	1.0e-09	4.49	-5.4	7.4e-08	0.00	0.25	0.75	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	DNTTIP1	0.07	0.08	blup	54	0.11	3.3e-11	3.97	-5.3	1.0e-07	-0.02	0.36	0.64	FALSE
7	GTEx	Heart Left Ventricle	DNTTIP1	0.07	0.11	lasso	3	0.09	9.9e-06	4.81	-5.3	1.1e-07	0.00	0.37	0.60	FALSE
36	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DNTTIP1	0.08	0.07	blup	54	0.04	9.7e-03	5.90	-5.3	1.4e-07	0.00	0.04	0.51	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	STK4	0.05	0.02	blup	89	0.03	1.1e-03	-3.31	5.2	1.7e-07	0.01	0.06	0.82	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	WFDC3	0.26	0.36	enet	12	0.38	7.7e-23	5.71	-5.2	1.9e-07	0.02	0.87	0.13	FALSE
45	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	WFDC3	0.51	0.39	blup	57	0.42	8.7e-13	5.75	-5.2	1.9e-07	0.01	0.50	0.50	FALSE
13	METSIM	Adipose	SLPI	0.05	0.01	lasso	7	0.02	1.0e-03	-4.08	-5.2	2.2e-07	0.06	0.11	0.79	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	WFDC3	0.42	0.60	enet	18	0.62	4.8e-90	5.91	-5.2	2.3e-07	0.02	0.85	0.15	FALSE
30	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	WFDC3	0.30	0.26	lasso	7	0.29	4.3e-14	5.71	-5.2	2.4e-07	0.00	0.86	0.14	FALSE