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chr1:18,972,776-21,664,475

Best TWAS P=1.05e-11 · Best GWAS P=1.3e-11 conditioned to 0.0287

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Nerve Tibial	CAPZB	0.07	0.03	enet	14	0.01	3.5e-02	5.6	-6.8	1.0e-11	-0.84	0.11	0.84	TRUE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MUL1	0.10	0.07	lasso	4	0.11	4.2e-12	4.6	-5.8	7.2e-09	0.03	0.04	0.95	TRUE
9	ROSMAP	Brain Pre-frontal Cortex	PINK1	0.26	0.22	lasso	5	0.26	2.2e-33	-5.7	-5.6	1.9e-08	0.00	0.02	0.98	TRUE
7	ROSMAP	Brain Pre-frontal Cortex	CAPZB	0.28	0.39	lasso	4	0.38	9.4e-52	6.3	-6.3	2.2e-10	-0.90	0.11	0.89	FALSE
10	YFS	Blood	CAPZB	0.06	0.10	bslmm	534	0.09	5.1e-29	6.3	-6.2	5.7e-10	-0.89	0.12	0.88	FALSE
3	GTEx	Artery Aorta	CAPZB	0.14	0.10	lasso	6	0.10	5.0e-06	5.8	-6.2	6.0e-10	-0.88	0.09	0.90	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CAPZB	0.13	0.16	lasso	4	0.16	1.8e-19	6.1	-6.1	9.8e-10	-0.88	0.19	0.81	FALSE
4	GTEx	Artery Tibial	CAPZB	0.09	0.07	lasso	4	0.06	8.1e-06	6.5	-6.1	1.2e-09	-0.87	0.03	0.96	FALSE
2	GTEx	Adipose Subcutaneous	CAMK2N1	0.17	0.03	enet	30	0.03	8.9e-04	-3.3	5.6	2.4e-08	0.06	0.32	0.13	FALSE
11	YFS	Blood	CDA	0.32	0.31	enet	48	0.41	7.8e-145	-4.2	-5.4	7.2e-08	0.00	0.97	0.02	FALSE
15	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MUL1	0.07	0.06	blup	57	0.05	7.5e-04	4.8	-5.3	9.0e-08	0.02	0.04	0.70	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	MUL1	0.10	0.07	lasso	6	0.13	3.1e-26	4.6	-5.3	1.1e-07	0.03	0.10	0.88	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MUL1	0.14	0.09	enet	8	0.12	9.4e-14	-3.8	-5.2	1.7e-07	0.04	0.01	0.98	FALSE
6	GTEx	Thyroid	MUL1	0.26	0.13	lasso	3	0.24	1.8e-18	4.6	-5.2	1.9e-07	0.05	0.85	0.15	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	MUL1	0.43	0.43	lasso	6	0.48	3.8e-69	4.6	-5.2	2.6e-07	0.03	0.86	0.14	FALSE