[Hub]/) : Traits : Blood Platelet Count : ← →

chr1:6,149,122-12,786,444

Best TWAS P=8.75e-103 · Best GWAS P=6.46e-99 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
30	GTEx	Testis	MFN2	0.41	0.39	enet	16	0.39	1.2e-18	-21.06	21.5	8.7e-103	-0.97	0.00	1.00	TRUE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MFN2	0.02	0.02	blup	57	0.02	4.0e-03	15.07	17.8	3.0e-71	-0.73	0.09	0.21	TRUE
42	NTR	Blood	KIF1B	0.11	0.08	enet	11	0.09	3.7e-28	-13.91	-14.1	2.8e-45	-0.05	0.00	1.00	TRUE
46	NTR	Blood	TNFRSF9	0.02	0.00	enet	18	0.00	8.1e-03	4.18	10.1	4.6e-24	-0.06	0.05	0.52	TRUE
38	METSIM	Adipose	MFN2	0.06	0.07	lasso	3	0.06	1.0e-08	9.74	9.8	1.7e-22	-0.37	1.00	0.00	TRUE
51	YFS	Blood	CAMTA1	0.07	0.03	lasso	4	0.05	1.0e-14	-9.31	-8.8	8.6e-19	-0.03	1.00	0.00	TRUE
47	ROSMAP	Brain Pre-frontal Cortex	CLCN6	0.06	0.00	bslmm	467	0.02	9.9e-04	-0.37	-8.4	2.9e-17	0.10	0.17	0.04	TRUE
6	GTEx	Artery Tibial	CLCN6	0.14	0.04	lasso	6	0.04	5.0e-04	-6.17	-7.2	4.3e-13	0.03	0.88	0.01	TRUE
49	ROSMAP	Brain Pre-frontal Cortex	MIIP	0.10	0.07	enet	14	0.09	1.2e-11	5.68	-6.9	4.7e-12	0.29	1.00	0.00	TRUE
17	GTEx	Heart Left Ventricle	ENO1	0.09	0.04	lasso	4	0.00	2.0e-01	-6.54	-6.5	6.9e-11	-0.04	0.14	0.38	TRUE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	MIIP	0.15	0.11	lasso	2	0.08	2.0e-03	5.68	-6.4	1.8e-10	0.27	0.10	0.29	TRUE
52	YFS	Blood	ENO1	0.07	0.06	lasso	7	0.06	5.1e-19	-6.97	6.3	3.0e-10	0.01	1.00	0.00	TRUE
5	GTEx	Adipose Visceral Omentum	CAMTA1	0.26	0.05	enet	61	0.06	5.6e-04	6.13	5.5	3.0e-08	0.06	0.18	0.55	TRUE
16	GTEx	Esophagus Mucosa	MFN2	0.19	0.19	enet	14	0.14	2.6e-09	-21.06	21.1	2.1e-98	-0.97	0.00	1.00	FALSE
57	YFS	Blood	PLOD1	0.25	0.30	enet	31	0.36	8.7e-124	15.61	15.8	2.3e-56	-0.63	1.00	0.00	FALSE
35	GTEx	Whole Blood	KIAA2013	0.17	0.14	enet	19	0.16	1.6e-14	15.62	15.6	5.0e-55	-0.68	0.99	0.01	FALSE
29	GTEx	Spleen	MFN2	0.36	0.18	enet	12	0.18	2.6e-05	15.07	15.3	8.4e-53	-0.61	0.48	0.42	FALSE
13	GTEx	Colon Transverse	MFN2	0.16	0.05	lasso	5	0.08	1.2e-04	15.17	15.1	1.6e-51	-0.57	0.09	0.88	FALSE
53	YFS	Blood	KIAA2013	0.11	0.12	lasso	5	0.12	4.8e-37	13.78	15.0	6.9e-51	-0.57	1.00	0.00	FALSE
37	GTEx	Whole Blood	MIIP	0.22	0.19	lasso	3	0.19	2.5e-17	15.58	14.9	2.6e-50	-0.61	1.00	0.00	FALSE
32	GTEx	Vagina	FBXO6	0.45	0.14	lasso	8	0.10	3.2e-03	15.61	-14.8	1.2e-49	0.64	0.06	0.36	FALSE
26	GTEx	Skin Sun Exposed Lower leg	MFN2	0.10	0.02	lasso	3	0.01	5.1e-02	15.17	14.8	2.0e-49	-0.57	0.09	0.86	FALSE
36	GTEx	Whole Blood	MFN2	0.40	0.48	lasso	3	0.53	1.6e-56	15.62	14.2	4.5e-46	-0.58	1.00	0.00	FALSE
20	GTEx	Lung	MFN2	0.18	0.11	lasso	6	0.12	9.6e-10	15.60	14.1	7.5e-45	-0.56	1.00	0.00	FALSE
34	GTEx	Whole Blood	PLOD1	0.19	0.16	lasso	5	0.22	6.9e-20	15.60	14.0	1.5e-44	-0.56	1.00	0.00	FALSE
55	YFS	Blood	MFN2	0.45	0.58	lasso	7	0.65	2.1e-290	9.74	13.4	7.9e-41	-0.52	1.00	0.00	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	MFN2	0.11	0.04	lasso	6	0.05	1.4e-06	11.29	-12.9	5.4e-38	0.60	0.71	0.21	FALSE
75	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PLOD1	0.15	0.13	enet	9	0.06	1.9e-03	11.29	-12.7	3.7e-37	0.63	0.39	0.16	FALSE
1	GTEx	Adipose Subcutaneous	MFN2	0.18	0.12	lasso	5	0.12	4.6e-10	13.78	12.6	1.4e-36	-0.47	1.00	0.00	FALSE
54	YFS	Blood	KIF1B	0.30	0.26	enet	49	0.29	7.8e-97	-13.91	-12.5	8.4e-36	-0.06	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Colon Adenocarcinoma	MFN2	0.09	0.06	enet	8	0.07	4.2e-05	9.74	11.9	1.3e-32	-0.47	0.35	0.44	FALSE
12	GTEx	Cells Transformed fibroblasts	MFN2	0.17	0.17	lasso	5	0.19	4.4e-14	9.74	11.8	2.2e-32	-0.45	1.00	0.00	FALSE
43	NTR	Blood	MFN2	0.14	0.16	lasso	3	0.17	5.1e-52	9.74	11.6	3.4e-31	-0.45	1.00	0.00	FALSE
45	NTR	Blood	PLOD1	0.03	0.03	lasso	3	0.02	1.8e-08	9.73	11.4	3.3e-30	-0.40	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	MFN2	0.22	0.08	enet	4	0.10	7.5e-06	9.74	11.3	1.3e-29	-0.45	0.90	0.03	FALSE
2	GTEx	Adipose Subcutaneous	RP3-467L1.6	0.08	0.00	enet	3	0.01	8.3e-02	-9.93	-9.9	3.3e-23	0.01	0.13	0.04	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	RERE	0.04	0.01	blup	154	0.01	3.1e-02	-6.65	9.4	5.0e-21	-0.01	0.05	0.27	FALSE
62	The Cancer Genome Atlas	Colon Adenocarcinoma	MIIP	0.05	0.04	enet	3	0.04	2.8e-03	9.80	-9.2	2.9e-20	0.44	0.07	0.16	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	PGD	0.17	0.14	lasso	6	0.08	1.7e-03	-4.91	-8.5	1.3e-17	0.03	0.23	0.39	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	MIIP	0.03	0.03	lasso	4	0.02	1.1e-05	5.68	-8.5	2.1e-17	0.35	0.98	0.00	FALSE
14	GTEx	Colon Transverse	DFFA	0.13	0.01	enet	7	0.01	9.0e-02	-6.79	8.4	6.3e-17	-0.03	0.06	0.55	FALSE
15	GTEx	Esophagus Mucosa	KIF1B	0.10	0.00	enet	17	0.01	1.2e-01	4.08	8.2	1.5e-16	0.04	0.05	0.79	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	RERE	0.06	0.01	blup	154	0.03	2.7e-04	-4.00	8.1	6.8e-16	-0.01	0.38	0.11	FALSE
39	METSIM	Adipose	MTHFR	0.08	0.01	blup	482	0.03	1.9e-05	-4.31	-8.0	1.6e-15	0.25	0.48	0.03	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	MIIP	0.07	0.07	enet	5	0.07	3.6e-08	5.68	-7.8	8.8e-15	0.35	0.99	0.00	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VAMP3	0.06	0.00	blup	58	0.02	1.6e-03	3.44	7.5	4.5e-14	0.01	0.05	0.25	FALSE
22	GTEx	Lung	SLC45A1	0.09	0.00	enet	13	0.04	9.7e-04	-5.47	-7.5	7.2e-14	-0.01	0.45	0.02	FALSE
41	NTR	Blood	CLCN6	0.01	0.01	lasso	2	0.01	3.0e-04	-6.17	-7.0	2.2e-12	0.03	0.81	0.00	FALSE
24	GTEx	Nerve Tibial	CLCN6	0.11	0.04	lasso	2	0.05	3.5e-04	-6.71	-6.8	7.2e-12	0.10	0.49	0.02	FALSE
56	YFS	Blood	PER3	0.03	0.01	enet	17	0.02	1.6e-06	9.42	-6.8	9.2e-12	-0.05	0.83	0.04	FALSE
19	GTEx	Lung	ENO1	0.10	0.07	lasso	4	0.07	4.6e-06	-6.36	-6.8	1.2e-11	0.00	0.89	0.07	FALSE
23	GTEx	Muscle Skeletal	SLC45A1	0.08	0.08	lasso	4	0.06	8.0e-07	-6.65	-6.6	3.6e-11	0.05	0.96	0.00	FALSE
69	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NPPA	0.08	0.02	blup	79	0.03	1.0e-02	-3.23	6.6	5.1e-11	-0.28	0.09	0.06	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	APITD1	0.07	0.01	enet	12	0.04	4.6e-04	0.67	-6.5	6.9e-11	0.06	0.02	0.11	FALSE
25	GTEx	Skin Sun Exposed Lower leg	CLCN6	0.08	0.00	lasso	3	0.01	7.9e-02	-4.31	-6.5	8.9e-11	0.00	0.10	0.03	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	MTHFR	0.33	0.12	lasso	6	0.09	7.9e-04	-6.33	-6.3	2.4e-10	0.00	0.44	0.03	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	RERE	0.08	0.00	blup	154	0.03	6.8e-03	5.34	6.3	2.4e-10	-0.02	0.05	0.08	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PGD	0.04	0.03	lasso	4	0.02	2.1e-03	-6.44	-6.3	2.5e-10	0.00	0.06	0.39	FALSE
28	GTEx	Spleen	CLCN6	0.21	0.10	lasso	3	0.06	1.3e-02	-6.24	-6.1	1.4e-09	-0.04	0.13	0.05	FALSE
31	GTEx	Thyroid	DFFA	0.06	0.07	enet	5	0.04	8.1e-04	3.93	6.0	2.4e-09	-0.11	0.20	0.42	FALSE
9	GTEx	Breast Mammary Tissue (Female)	RERE	0.14	0.12	lasso	3	0.08	2.4e-03	-6.32	6.0	2.7e-09	-0.02	0.16	0.04	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	VAMP3	0.05	0.03	enet	11	0.03	9.1e-05	3.52	5.9	2.8e-09	0.06	0.23	0.05	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	MTHFR	0.07	0.01	blup	92	0.04	2.9e-03	-6.71	-5.7	1.2e-08	0.00	0.06	0.14	FALSE
7	GTEx	Brain Caudate basal ganglia	KIF1B	0.25	0.00	lasso	5	0.02	1.1e-01	0.44	5.5	3.3e-08	0.05	0.04	0.42	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	CAMTA1	0.08	0.03	bslmm	875	0.06	7.9e-08	-6.88	5.5	3.7e-08	0.10	0.97	0.01	FALSE
40	METSIM	Adipose	PLOD1	0.05	0.01	enet	16	0.02	6.5e-04	-12.16	5.5	4.2e-08	-0.27	0.94	0.01	FALSE
18	GTEx	Heart Left Ventricle	SLC45A1	0.15	0.24	lasso	1	0.23	1.2e-12	-5.47	-5.5	4.4e-08	0.06	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PEX14	0.08	0.01	enet	8	0.05	3.1e-03	3.71	5.5	5.1e-08	-0.09	0.04	0.29	FALSE
21	GTEx	Lung	DFFA	0.11	0.01	enet	30	0.00	1.9e-01	-3.81	5.3	8.8e-08	-0.04	0.19	0.17	FALSE
27	GTEx	Skin Sun Exposed Lower leg	PGD	0.08	0.06	lasso	5	0.06	1.3e-05	5.31	-5.3	9.1e-08	0.01	0.75	0.08	FALSE
44	NTR	Blood	MTHFR	0.09	0.07	enet	17	0.10	4.4e-31	-4.45	-5.3	9.4e-08	-0.05	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	RERE	0.22	0.17	lasso	5	0.17	5.2e-09	-3.76	5.2	1.5e-07	0.01	0.98	0.00	FALSE
33	GTEx	Whole Blood	CLCN6	0.10	0.02	lasso	3	0.04	2.1e-04	-6.17	-5.2	1.5e-07	-0.02	0.38	0.03	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RERE	0.04	0.02	blup	154	0.02	8.7e-04	-2.94	5.2	1.5e-07	-0.01	0.27	0.02	FALSE
8	GTEx	Brain Cerebellum	CLCN6	0.25	0.05	lasso	8	0.06	9.3e-03	-6.65	-5.2	1.6e-07	0.04	0.18	0.04	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	MIIP	0.09	0.08	enet	4	0.08	4.2e-09	5.68	-5.2	1.7e-07	0.23	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIF1B	0.05	0.01	blup	108	0.01	9.4e-04	-4.31	-5.1	2.8e-07	-0.01	0.31	0.09	FALSE