Hub : Genes

CAMK2N1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1680	0.0450	8.0e-06	0.030	NA	0.034	NA	0.029	1.6e-03	NA	8.8e-04	NA	1.9e-03
2	GTEx	Esophagus Muscularis	0.2910	0.0610	5.5e-07	0.117	NA	0.158	NA	0.136	1.5e-07	NA	7.3e-10	NA	1.4e-08
3	GTEx	Muscle Skeletal	0.1093	0.0352	6.8e-04	-0.003	NA	0.029	NA	0.008	8.9e-01	NA	6.9e-04	NA	4.7e-02
4	GTEx	Nerve Tibial	0.1345	0.0589	9.6e-03	0.053	NA	0.023	NA	0.038	1.3e-04	NA	8.2e-03	NA	9.9e-04
5	ROSMAP	Brain Pre-frontal Cortex	0.0464	0.0210	1.4e-02	0.002	0.012	0.006	0.012	0.002	1.8e-01	9.1e-03	4.3e-02	8.5e-03	1.6e-01
6	YFS	Blood	0.0551	0.0177	1.1e-05	0.026	0.016	0.037	0.033	0.040	4.7e-09	3.1e-06	2.9e-12	5.5e-11	5.1e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.1	3.3	8.1	-2.8	-2.2	-2.5	-0.7	0.4	-0.1
Bipolar Disorder or Schizophrenia	1.6	4.0	9.0	-2.9	-3.0	-2.4	0.0	-0.8	0.0
Depressed Affect (Nagel 2018)	0.5	1.1	2.3	-0.2	-1.5	-1.0	0.3	1.0	-1.5
Depression (Nagel 2018)	0.9	1.3	5.1	0.1	-1.4	-0.1	0.5	0.6	-2.3
Intelligence (Savage-Jansen 2018)	2.1	6.3	16.6	2.9	4.1	1.8	2.4	-1.9	0.1
Neuroticism (Nagel 2018)	0.5	1.2	2.2	0.6	-1.1	-1.1	1.3	0.5	-1.5
Schizophrenia (2018)	0.8	1.6	4.4	-1.4	-2.1	-1.0	0.6	-1.4	0.1
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	1.1	-0.6	0.9	1.0	0.0	1.3
Worry (Nagel 2018)	0.5	1.0	1.6	0.7	-1.3	-0.9	1.2	0.9	-1.0
Alzheimer’s Disease (in mother)	0.7	0.8	3.1	-0.5	0.8	0.2	-0.7	-0.6	1.8
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.1	-0.7	0.2	0.7	-0.2	0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.2	-0.0	0.4	0.5	-0.0	-0.1	1.1
Crohns Disease (2017)	0.5	1.0	3.3	-0.8	1.2	0.8	0.1	-0.2	1.8
Irritable Bowel Disease (IBD)	0.3	0.8	2.4	-1.5	0.0	0.4	-0.9	-0.3	1.0
Ulcerative Colitis (UC)	0.6	1.0	3.5	-1.5	-0.7	0.1	-1.9	-0.1	-0.0
Major Depression (MDD)	0.2	0.3	1.0	-1.0	-0.4	-0.7	-0.1	0.1	0.3
Reaction Time	1.3	2.5	5.8	-1.7	-1.8	-0.6	-1.6	0.4	2.4
Verbal and Numeric Reasoning (VNR)	2.8	6.7	22.8	2.2	4.8	1.8	0.5	-2.5	1.5
Breast Cancer	0.2	0.6	2.6	0.5	0.0	0.1	-0.4	0.6	-1.6
Ovarian Cancer	1.1	1.5	3.8	-2.0	-0.1	-1.7	-1.3	-0.8	-0.1
Prostate Cancer	1.0	1.4	3.3	1.1	1.5	1.0	0.7	-0.7	1.8
Age at First Birth	0.8	1.1	1.8	-1.1	-0.9	-1.2	-1.4	-1.0	0.7
Bipolar Disorder (2011)	0.5	0.5	1.4	-1.0	0.2	-0.5	-1.2	-0.2	0.6
Body Mass Index (BMI) (2010)	0.8	1.1	2.9	-0.0	-1.7	-0.9	1.3	0.4	-1.1
Coronary Artery Disease (CAD)	2.2	2.6	10.7	1.7	-0.7	0.8	3.3	0.0	-0.8
Crohns Disease (2012)	0.3	0.5	0.9	-0.7	0.8	0.7	0.9	0.0	0.5
Mean Putamen Volume	0.2	0.2	0.5	-0.3	0.3	0.4	0.7	-0.1	0.7
Fasting Glucose	2.8	3.3	9.9	0.9	0.7	-2.0	2.1	3.2	-0.5
HbA1C	0.6	0.7	2.8	0.3	-0.8	-0.6	0.2	1.7	0.1
HDL Cholesterol	1.4	2.3	10.2	-1.7	0.6	0.6	-3.2	-0.3	0.2
LDL Cholesterol	0.5	0.8	2.3	1.5	0.9	1.0	0.7	-0.4	0.3
Lupus	0.7	1.0	3.2	0.6	-1.1	-0.4	-0.1	1.2	1.8
Neuroticism (2016)	0.4	0.6	1.8	-1.0	-1.4	-0.7	0.4	-0.2	-0.1
Primary Biliary Cirrhosis	2.2	3.1	11.8	-0.7	-2.2	0.6	-0.8	3.4	-0.5
Rheumatoid Arthritis	0.3	0.4	1.0	0.8	0.0	-0.2	1.0	-0.4	0.9
Schizophrenia (2014)	0.7	1.6	4.0	-1.5	-2.0	-1.1	1.2	-0.5	-0.4
Triglycerides	4.2	6.8	21.3	4.6	2.7	2.2	2.7	-0.0	0.4
Type 2 Diabetes (T2D) (2012)	2.1	2.4	8.9	0.2	-0.5	-0.9	2.1	3.0	0.4
Ulcerative Colitis	1.6	2.3	4.3	-2.0	-2.1	-1.0	-1.9	-0.3	-1.0
Blood Eosinophil Count	0.0	0.3	0.8	-0.8	0.1	0.1	-0.0	0.2	0.9
Blood Platelet Count	1.1	12.3	31.1	5.6	4.3	3.2	-0.1	0.1	3.7
Blood Red Count	1.3	12.2	22.5	4.7	2.5	4.2	2.0	3.9	2.8
Blood White Count	0.8	6.3	15.3	3.9	2.8	1.2	1.9	1.0	2.9
Heel T-Score	0.2	1.8	4.5	-2.0	-0.0	0.9	-2.1	-0.0	1.2
BMI	0.5	3.0	9.7	1.2	-1.1	-1.0	3.1	2.2	-0.1
Height	1.0	18.3	42.4	-6.2	-6.5	-2.7	-2.7	-1.3	-3.6
Waist Hip Ratio (WHR)	1.0	4.6	10.8	1.9	1.3	1.5	0.7	3.0	3.3
Systolic Blood Pressure	1.6	8.1	14.1	3.3	3.8	3.0	0.5	-0.6	3.7
Smoking Status	0.2	0.5	1.4	-0.6	-0.6	-1.2	0.7	0.3	-0.5
Allergy or Eczema	0.3	0.8	3.3	0.4	-0.7	-0.2	0.5	-0.9	-1.8
Cardiovascular Disease	1.2	4.1	10.5	2.1	3.2	1.8	1.3	0.2	2.1
Hypothyroidism (self reported)	0.7	1.7	3.9	-2.0	-1.7	0.1	0.0	-1.1	-1.5
Respiratory disease	0.3	0.7	1.9	-0.1	0.2	-0.1	0.9	-1.3	-1.4
Type 2 Diabetes (T2D) (2018)	0.6	1.0	4.3	0.0	1.1	-0.5	0.2	2.1	0.6
Lung FEV1/FVC ratio	0.5	2.4	5.9	2.4	0.7	1.6	1.1	1.3	1.6
Lung FVC	0.6	3.2	7.6	1.8	2.8	1.5	-2.2	-1.0	0.9
Neuroticism	0.3	0.8	2.0	0.3	-1.1	-0.5	0.9	0.8	-1.4
Chronotype (morning person)	0.6	1.5	5.1	2.3	1.1	1.4	0.4	0.3	0.4
Hair Pigment	0.0	0.7	3.7	-0.5	0.3	-0.1	0.4	-0.3	-1.9
Tanning	0.1	0.8	2.0	0.8	-0.6	-1.4	0.1	1.3	0.7
Hand grip strength (left)	0.6	1.6	3.1	-1.5	0.2	0.0	-1.5	-1.8	-1.5
Number of treatments/medications taken	0.7	1.3	3.8	1.3	1.9	0.4	1.0	0.1	1.1
Average weekly spirits intake	1.5	1.8	4.2	1.8	0.5	1.3	2.0	1.3	-0.3
Sensitivity / hurt feelings	0.7	1.2	3.4	-0.9	-0.8	-1.9	1.0	-0.1	-1.2
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	0.6	-0.5	0.4	0.6	0.7	-1.2
Hearing difficulty/problems: Yes	1.1	1.7	2.9	-1.2	-1.4	-1.4	-0.8	-1.1	-1.7
Relative age of first facial hair	0.3	0.7	1.6	0.5	0.5	0.4	1.2	-0.5	-1.3
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	5.9	-1.9	0.7	-0.9	-2.4	2.4	1.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.8	-0.1	0.6	0.2	0.7	-0.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.1	-0.4	1.1	-0.8	0.3	-0.1	-0.7
Systolic blood pressure, automated reading	1.1	3.1	6.4	1.7	1.8	1.7	-1.0	1.5	2.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.0	0.0	0.5	0.6	0.7	-0.8
Angina	1.1	1.4	3.2	1.2	1.8	-0.4	0.6	-0.1	1.8
Medication for hormone replacement therapy	1.0	1.2	3.8	0.5	-0.5	1.9	-0.1	-1.2	-1.1
Vitamin and mineral supplements	1.1	1.5	4.7	1.6	0.7	0.7	2.2	0.3	-0.5
Supplements: Zinc	2.4	2.6	8.0	-0.2	-1.3	0.4	-2.4	2.8	-0.0
Medication: Co-codamol	0.4	0.5	1.5	0.7	0.3	0.3	0.6	-0.6	-1.2
Medication: Metformin	0.3	0.4	2.0	0.6	1.4	-0.3	-0.0	0.4	0.1
Diabetes (father)	0.1	0.1	0.4	0.4	0.6	-0.3	0.1	-0.5	-0.1
Diabetes (mother)	0.5	0.6	2.5	0.3	-1.6	-0.7	-0.4	-0.1	-0.5
Severe depression (siblings)	0.5	0.5	1.2	0.4	-0.6	-1.1	0.2	0.5	-1.1
Pack years adult smoking proportion	1.0	1.6	3.4	-1.8	-0.7	-1.5	-1.4	1.3	0.1
Impedance of leg (right)	0.3	1.6	5.2	1.1	0.9	1.1	-0.1	-0.9	2.3
Leg fat-free mass (left)	0.6	3.2	8.5	-1.7	-2.5	-0.8	0.8	0.1	-2.9
Trunk fat percentage	0.6	2.5	8.5	0.3	-1.1	-1.0	2.9	1.7	-1.2
Hand grip strength (right)	0.5	1.3	3.9	-1.3	1.0	0.5	-0.9	-2.0	-0.2
Townsend deprivation index at recruitment	2.6	3.7	8.0	-2.8	-2.5	-2.6	-0.5	-0.2	0.9
Current tobacco smoking	1.0	1.6	5.8	-1.1	-1.3	-2.4	0.4	1.0	-0.1
Average weekly fortified wine intake	0.8	1.0	2.9	-0.5	0.6	0.4	-0.9	1.2	-1.7
Maternal smoking around birth	0.7	1.0	2.5	0.2	-0.6	0.3	1.5	0.8	-1.6
Fed-up feelings	0.1	0.2	0.6	-0.4	-0.8	-0.2	-0.0	0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	2.1	0.1	-0.0	0.7	-0.2	-0.2	-1.5
Relative age voice broke	0.7	1.1	2.6	-0.3	1.5	1.6	-0.4	-0.8	-1.0
Taking other prescription medications	0.3	0.5	1.1	-0.1	0.7	-0.5	0.8	-0.8	1.1
Age when periods started (menarche)	0.9	2.2	3.9	-1.9	1.1	-1.4	-1.2	-2.0	1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.6	-0.7	0.0	-0.3	0.1	1.3	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	2.0	-1.4	-0.1	-0.6	0.1	-0.3	-0.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.8	0.6	0.4	1.7	0.6	0.1	-0.7
Qualifications: CSEs or equivalent	1.9	2.5	4.8	2.2	1.5	1.6	2.1	0.6	0.8
Serious illness, injury or assault to yourself	1.5	1.8	4.4	-0.1	1.7	-0.3	0.5	1.8	2.1
High blood pressure	1.5	4.2	9.5	1.6	3.1	1.6	0.5	1.4	2.9
Hayfever, allergic rhinitis or eczema	0.7	1.5	5.0	-0.3	-0.7	-0.3	0.3	-2.2	-1.8
Multivitamins +/- minerals	2.6	3.3	7.0	-2.6	-1.7	-1.3	-2.6	0.3	-1.2
Stomach or abdominal pain in last month	0.7	0.9	1.6	1.3	0.8	1.0	1.2	0.4	-0.7
Supplements: Glucosamine	1.3	1.7	7.2	-0.8	0.3	-0.3	-2.7	-1.4	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	-0.5	-0.5	-0.2	-0.3	0.1	0.6
Medication: Atenolol	0.8	1.0	1.4	0.9	1.2	1.2	1.0	0.1	1.1
Medication: Levothyroxine sodium	0.8	1.4	3.3	-1.8	-1.5	-0.6	-0.8	-0.1	-1.3
Sitting height	1.3	9.3	21.4	-3.8	-4.6	-1.6	0.9	-1.9	-3.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	-0.2	-0.6	0.6	0.5	-0.6	-0.7
High blood pressure (mother)	0.7	1.0	4.3	0.1	-0.1	-0.0	0.9	-1.1	-2.1
Body mass index (BMI)	0.7	3.1	8.0	0.8	-1.3	-0.1	2.6	2.8	-1.2
Impedance of leg (left)	0.2	1.1	4.4	0.9	0.8	1.0	-0.3	-0.3	2.1
Leg predicted mass (left)	0.6	3.2	8.6	-1.8	-2.5	-0.8	0.8	0.1	-2.9
Trunk fat mass	0.6	2.8	7.3	-0.4	-1.9	-1.0	2.7	1.4	-1.6
Waist circumference	0.9	3.2	8.2	-0.3	-2.3	-1.1	2.1	2.9	-0.0
Number of incorrect matches in round	1.7	2.9	9.1	-2.1	-3.0	-1.9	-0.2	0.4	0.1
Past tobacco smoking	0.4	0.7	3.3	0.3	0.7	-0.0	-0.2	1.8	-0.5
Alcohol usually taken with meals	0.5	0.8	3.2	1.8	0.7	-0.1	0.4	1.0	0.5
Nervous feelings	1.1	2.0	7.0	-0.3	-2.7	-0.8	-0.1	1.0	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	5.2	-0.9	-0.7	0.9	-1.3	0.6	-2.3
Hearing difficulty/problems with background noise	1.7	2.7	8.4	-2.0	-2.9	-0.6	-1.0	0.2	-1.6
Hair/balding pattern: Pattern 2	0.7	0.9	3.0	1.0	0.7	1.7	-0.4	0.4	-0.4
Had menopause	1.6	2.0	4.8	-1.1	-2.2	-1.5	-0.7	1.4	1.0
Had other major operations	1.3	1.6	4.6	-2.1	-1.5	-1.0	-0.0	-0.1	-1.3
Forced vital capacity (FVC)	0.3	1.0	2.4	-0.3	-0.1	1.2	-1.4	-1.6	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	-0.6	-0.7	0.6	0.5	0.4	-0.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.8	0.3	0.6	-1.2	1.4	-0.7	1.3
Qualifications: None of the above	2.2	4.6	18.1	0.3	-2.7	1.2	0.8	4.2	-0.6
Financial difficulties in last 2 years	0.8	1.1	3.1	1.5	-0.6	-0.3	1.8	-0.1	-0.6
Mouth/teeth dental problems	0.4	0.6	1.5	-0.3	0.9	0.7	-0.7	0.5	1.2
Heart attack	1.4	1.8	8.0	0.7	0.7	0.2	2.8	0.0	1.4
Allergy	0.5	1.2	4.8	-0.2	0.9	0.1	-0.6	1.1	2.2
Pain all over the body in last month	1.8	1.9	5.8	1.5	-0.2	0.9	1.2	2.4	-1.1
Diabetes (self-reported)	0.7	1.0	3.6	1.0	1.9	0.5	0.2	1.1	0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	3.1	-0.7	-0.1	0.0	-0.6	0.2	-1.8
Medication: Ramipril	1.9	2.4	6.0	1.8	2.4	0.1	1.1	1.5	1.2
Medication: Simvastatin	1.0	1.4	6.0	0.7	2.5	1.0	0.5	-0.3	0.8
Fluid intelligence score	2.7	5.6	15.2	2.0	3.9	1.2	0.6	-3.1	1.8
Illnesses of siblings	0.6	0.8	2.1	1.3	-0.4	-0.1	1.4	-0.7	-0.8
Neuroticism score	0.6	1.2	3.1	-0.1	-1.0	-0.6	0.8	1.7	-1.4
Weight	0.8	3.7	7.9	-0.7	-2.8	-0.6	2.3	1.6	-2.3
Impedance of arm (right)	0.4	1.7	7.8	0.2	1.4	-0.1	-0.6	-2.8	-0.3
Arm fat percentage (right)	0.5	2.1	6.4	0.3	-1.0	-0.4	2.5	1.5	-1.7
Trunk fat-free mass	0.7	3.9	12.2	-2.5	-3.5	-0.7	-0.2	0.0	-2.2
Hip circumference	1.0	4.4	10.7	-1.2	-3.3	-1.5	1.6	1.8	-2.5
Time employed in main current job	2.1	2.5	4.9	2.0	2.2	2.0	0.4	-1.1	0.8
Alcohol intake versus 10 years previously	0.5	0.8	1.8	-0.8	0.2	-1.4	-0.9	-0.3	1.1
Father’s age at death	3.2	4.3	11.3	-3.0	-2.2	-0.6	-3.4	-0.4	-0.2
Worrier / anxious feelings	0.1	0.2	0.8	0.2	-0.5	0.1	0.6	-0.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.6	1.4	-0.1	0.3	1.9	-0.0	-0.9
Falls in the last year	0.4	0.6	1.5	-1.2	-0.1	-1.0	0.6	-0.5	0.5
Hair/balding pattern: Pattern 3	1.0	1.4	5.2	0.8	0.2	-0.7	1.1	-1.0	2.3
Number of live births	0.8	1.1	2.4	1.5	1.0	0.8	1.4	0.8	0.2
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.5	0.4	0.6	1.6	-1.2	-0.7	0.6
Pulse rate	0.4	0.7	3.0	1.7	0.0	0.3	0.6	0.4	0.8
Happiness	0.5	0.6	1.7	-0.8	0.4	-1.0	-1.3	0.3	0.4
Noisy workplace	0.1	0.1	0.2	0.5	-0.2	0.4	0.3	-0.2	0.1
Qualifications: A levels/AS levels or equivalent	1.6	3.6	10.1	0.3	3.2	1.3	-1.2	-2.8	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	0.6	-1.3	-1.1	0.5	-0.0	0.1
Mouth/teeth dental problems: Dentures	0.7	1.2	3.9	0.2	-2.0	-0.2	1.0	1.5	-0.1
Asthma	0.3	0.6	1.5	0.2	0.1	0.8	1.2	-1.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	5.5	2.4	0.3	1.6	0.6	-0.3	0.6
Medication: Cholesterol lowering	1.4	2.2	6.0	1.2	2.0	0.3	1.0	-1.0	2.5
Depression (self-reported)	0.9	1.0	2.9	1.0	1.0	-1.0	0.2	1.7	0.5
Medication: Lansoprazole	1.0	1.1	3.5	-0.2	0.7	0.8	1.9	1.2	0.7
Prospective memory result	1.4	1.7	5.5	-1.2	-2.3	-0.7	-1.4	0.1	1.0
Lung cancer (father)	1.0	1.1	2.5	1.3	0.5	-0.2	1.6	0.6	1.4
Illnesses of mother	1.1	1.3	3.8	1.1	0.5	1.9	1.5	-0.0	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.9	0.3	0.6	1.0	-1.1	-1.4	0.7
Pulse wave Arterial Stiffness index	0.9	1.0	3.2	-0.1	0.1	-1.8	-0.4	1.4	1.0
Impedance of arm (left)	0.3	1.5	5.2	0.3	1.8	-0.3	-0.3	-2.3	-0.3
Arm fat mass (right)	0.7	3.1	5.1	-0.3	-2.0	-0.6	2.1	2.1	-2.3
Trunk predicted mass	0.7	3.7	11.7	-2.4	-3.4	-0.5	-0.3	-0.0	-2.2
Standing height	0.8	7.7	16.6	-3.7	-4.1	-1.4	-0.4	-2.2	-3.1
Length of working week for main job	1.2	1.3	4.2	0.5	0.8	-0.1	2.0	-1.6	0.4
Exposure to tobacco smoke at home	1.3	1.5	4.2	0.5	-1.3	0.0	0.1	2.0	1.7
Breastfed as a baby	1.1	1.3	1.9	-0.6	-1.4	-1.4	1.3	-1.1	1.0
Tense / ‘highly strung’	0.5	0.8	2.7	0.4	-1.1	0.3	-0.1	1.6	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	1.0	-0.2	-0.4	-0.4	1.0	0.3	-0.2
Hair/balding pattern: Pattern 4	0.3	0.8	1.9	0.3	-0.3	0.2	-1.1	1.4	-1.3
Birth weight of first child	0.3	0.5	2.9	0.1	-0.2	-0.1	0.1	-1.7	0.6
Peak expiratory flow (PEF)	0.8	1.8	4.2	1.4	2.0	1.9	-0.3	0.8	-0.2
Pulse wave reflection index	1.1	1.4	4.3	-0.1	0.3	-1.2	-1.1	2.1	1.1
Ever highly irritable/argumentative for 2 days	1.4	1.7	5.8	0.1	0.3	0.8	1.7	2.4	0.7
Loud music exposure frequency	0.3	0.3	1.0	-0.1	-0.7	0.4	-0.2	1.0	-0.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	8.5	-0.2	0.6	-0.4	-0.9	-2.9	0.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.2	1.8	0.9	0.5	1.3	-0.2	-0.6
Blood clot in the leg (DVT)	0.8	1.1	1.9	1.3	0.7	0.1	1.3	0.8	-1.4
Medication: Paracetamol	2.5	4.2	8.1	2.8	1.8	2.7	2.3	0.3	-1.2
Headache pain in last month	0.9	1.6	4.9	2.2	1.9	0.5	0.4	0.4	0.6
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	6.8	-1.8	-2.2	-1.1	-1.0	-0.0	-2.6
Glaucoma (self-reported)	1.6	1.9	8.6	0.0	-2.9	-0.7	0.2	-1.0	-1.2
Gout (self-reported)	0.6	0.8	2.3	0.6	-0.2	1.3	1.5	-0.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.1	-1.8	-1.1	-0.1	-0.2	-1.2	-1.1
Medication: Amlodipine	1.4	1.9	4.6	1.9	1.4	2.1	0.8	0.3	0.7
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.3	0.5	0.1	0.2	-0.1	-0.2	-0.2
Birth weight	0.7	1.4	5.9	-0.8	-1.4	-0.0	-0.1	-2.4	0.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	3.1	0.6	-0.2	0.1	0.5	1.8	-0.5
High blood pressure (siblings)	0.4	0.6	0.9	-0.7	-0.9	0.7	-0.8	0.6	0.7
Forced vital capacity (FVC), Best measure	0.2	0.8	3.0	-0.4	-0.3	0.5	-1.2	-1.7	0.1
Body fat percentage	0.6	2.4	9.1	0.7	-0.8	-0.6	3.0	1.8	-0.9
Leg fat percentage (right)	0.9	3.3	8.9	1.7	-0.8	0.7	3.0	2.6	-0.3
Arm fat-free mass (right)	0.6	3.0	9.9	-1.7	-3.1	-0.8	0.8	1.2	-1.6
Exposure to tobacco smoke outside home	1.1	1.5	2.2	0.3	-1.5	1.2	1.4	1.3	-1.1
Comparative body size at age 10	0.5	1.5	6.3	1.1	2.5	0.5	-0.2	0.9	0.4
Number of full brothers	0.7	0.8	1.7	-0.3	-1.1	1.3	0.1	1.2	0.6
Worry too long after embarrassment	0.7	1.1	5.2	-0.1	-0.5	-0.9	0.7	0.1	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.1	0.0	-0.7	0.0	-0.5	-0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	0.1	0.5	-0.2	0.5	-0.3	-0.1
Number of children fathered	0.3	0.3	0.7	-0.4	-0.6	0.5	-0.0	0.5	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	0.6	-0.5	-1.1	1.2	-0.5	0.6
Age at first live birth	1.5	2.6	6.7	-1.1	1.1	0.2	-2.6	-2.4	0.8
Pulse wave peak to peak time	1.0	1.2	2.6	-0.4	-0.5	1.5	0.3	-1.6	-1.3
Health satisfaction	0.5	0.7	1.6	-0.8	1.2	-0.4	-0.6	-1.2	-0.1
Shortness of breath walking on level ground	1.2	1.4	5.1	-1.2	-0.7	0.3	0.5	-1.0	-2.2
Qualifications: College or University degree	2.3	7.4	25.6	-0.0	3.9	1.1	-1.5	-5.1	-0.6
Eye problems/disorders: None of the above	0.8	0.9	2.2	-0.3	0.4	-1.5	-0.9	-0.7	1.2
Mouth/teeth dental problems: Loose teeth	0.7	0.9	3.2	-0.4	-0.5	-0.8	0.3	1.8	-0.9
Emphysema/chronic bronchitis	0.4	0.4	0.9	-0.3	-0.5	-0.8	-0.9	-0.6	-0.5
Medication for pain relief, constipation, heartburn	1.4	2.4	4.8	-2.2	-1.8	-1.6	-1.9	-0.0	-0.6
Neck or shoulder pain in last month	0.5	0.7	2.7	0.2	-0.8	-0.6	-0.6	1.6	0.5
Medication: Blood pressure	1.1	1.9	4.7	1.3	1.6	1.1	0.9	0.5	2.2
Angina (self-reported)	1.0	1.3	3.3	1.3	1.8	-0.4	0.5	-0.2	1.7
Migraine (self-reported)	0.5	0.7	2.3	0.2	-1.5	-0.2	1.2	-0.2	-0.3
Medication: Ibuprofen	0.8	1.0	3.8	2.0	-0.2	1.0	0.4	-0.5	0.8
Medication: Allopurinol	0.4	0.5	1.2	-0.8	0.2	-0.5	0.4	-0.9	-1.1
Medication: Omeprazole	2.4	2.9	7.6	1.9	1.5	1.6	2.8	-0.1	-1.1
Medication: Seretide 50 evohaler	0.5	0.6	3.1	-0.2	-0.1	-1.8	0.6	0.2	-0.3
Mean time to correctly identify matches	2.2	4.2	6.6	-2.5	-2.4	-1.2	-2.2	0.7	2.6
Heart disease (mother)	1.0	1.3	3.7	-1.2	-0.6	-1.9	-1.1	-0.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.5	-1.2	-0.7	-0.6	0.5	1.4	1.6
Whole body fat mass	0.6	2.7	6.7	-0.2	-1.9	-0.7	2.6	1.9	-1.5
Leg fat mass (right)	0.7	2.8	7.0	0.5	-1.8	0.0	2.6	2.2	-1.2
Arm predicted mass (right)	0.6	3.2	10.9	-1.8	-3.3	-0.9	0.8	1.3	-1.5
Pulse rate, automated reading	0.7	2.2	6.9	2.6	0.5	-0.4	0.5	1.9	1.4
Alcohol intake frequency.	0.8	1.9	9.6	0.6	-0.1	-1.2	-0.2	3.1	0.4
Comparative height size at age 10	0.6	3.3	11.6	-2.2	-3.4	-1.6	-0.0	-0.1	-1.0
Number of full sisters	1.6	1.9	7.1	-1.5	-1.3	-2.7	-0.3	0.6	-0.2
Suffer from ‘nerves’	0.7	1.1	2.5	0.2	-0.8	-1.0	1.4	1.6	-0.6
Overall health rating	1.1	2.4	5.4	1.7	-0.3	-0.7	0.9	2.2	2.3
Chest pain or discomfort	0.4	0.6	2.3	0.8	0.4	-0.6	1.5	0.1	0.5
Had major operations	1.5	1.8	4.8	2.2	1.9	0.1	1.3	-0.5	-0.6
Age at last live birth	1.5	2.2	4.4	-0.7	1.8	0.0	-1.6	-2.1	1.6
Family relationship satisfaction	0.5	0.7	2.9	-0.1	-0.1	-0.7	-0.4	-1.7	0.7
Leg pain on walking	0.6	0.7	2.4	0.4	-0.3	0.7	1.6	-0.4	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	0.1	-1.1	1.0	0.6	0.2	0.7
Commuting to job workplace: Car/motor vehicle	2.7	3.1	7.5	1.3	2.7	1.7	1.9	-0.2	1.6
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	5.9	-1.0	0.1	0.7	-1.8	-2.4	-1.4
Medication: Aspirin	0.6	0.8	2.6	0.1	1.6	-0.4	-0.4	0.1	1.3
Supplements: Vitamin C	0.4	0.5	1.3	0.1	-1.1	-0.8	0.9	0.1	0.4
Knee pain experienced in last month	0.2	0.4	1.1	0.4	-0.8	-0.2	-0.2	0.3	1.0
Hypertension (Self-reported)	1.5	4.3	10.7	1.5	3.3	1.9	0.6	1.4	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	4.4	0.2	-0.2	0.1	2.1	0.9	-0.8
Illnesses of father: Heart disease	0.7	1.0	3.5	1.3	1.9	-0.2	-0.3	0.3	0.8
Illnesses of siblings: Diabetes	0.3	0.4	0.8	-0.5	0.8	0.7	-0.9	0.2	0.3
Smoking status: Previous	0.7	1.1	3.6	0.4	-0.0	1.0	0.4	-1.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	-0.7	-0.0	0.7	-0.2	-0.7	0.5
Whole body fat-free mass	0.7	3.8	10.5	-2.2	-3.2	-0.7	0.3	0.3	-2.6
Leg fat-free mass (right)	0.6	3.3	8.6	-1.9	-2.5	-1.0	0.6	0.3	-2.9
Arm fat percentage (left)	0.6	2.2	7.8	0.4	-0.7	-0.5	2.8	1.5	-1.6
Average weekly red wine intake	1.0	1.5	4.3	1.4	2.1	-0.4	1.4	-0.7	-0.1
Handedness (chirality/laterality): Left-handed	1.6	1.9	5.1	-2.1	-0.2	-2.3	-0.2	0.8	-1.0
Mood swings	0.6	1.0	3.0	-1.5	-1.7	-0.6	-0.3	0.7	-0.4
Loneliness, isolation	1.1	1.6	4.3	2.1	-0.0	0.6	0.5	1.8	-1.1
Long-standing illness, disability or infirmity	2.4	3.6	8.0	0.4	0.6	-2.8	1.5	1.8	2.8
Ever had bowel cancer screening	0.7	0.8	2.1	0.2	-1.1	0.7	1.5	-0.1	-1.0
Diabetes diagnosed by doctor	0.4	0.7	2.1	0.2	1.5	0.0	-0.2	1.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	1.0	0.3	-0.3	0.5	0.7	0.7
Friendships satisfaction	0.5	0.6	2.1	0.4	0.6	-0.2	0.7	-1.4	-0.6
Qualifications: nursing, teaching	2.6	4.0	9.6	-1.3	2.8	-0.3	-1.8	-3.1	-1.1
Commuting to job workplace: Walk	1.6	1.7	6.0	-0.6	-1.2	-2.5	-0.1	0.9	-1.2
Eye problems/disorders: Cataract	1.2	1.3	3.7	1.2	1.4	1.9	0.8	0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.1	-0.4	0.5	-0.5	0.4	-0.8	-1.0
Medication for cholesterol	0.7	1.1	2.8	-1.0	-1.2	-0.8	-1.7	-0.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	-0.1	-0.5	1.2	-0.1	1.0	-1.1
Back pain experienced in last month	0.6	0.8	1.7	-0.3	-1.2	-0.7	1.3	0.3	1.2
Mineral and other dietary supplements	2.3	3.2	12.9	1.5	-0.2	0.5	3.6	-0.9	-1.6
Breast cancer (self-reported)	0.1	0.1	0.3	-0.6	0.0	-0.3	-0.2	0.3	0.3
Asthma (self-reported)	0.3	0.6	1.4	0.3	0.2	0.9	1.0	-1.2	-0.5
Osteoporosis (self-reported)	0.8	1.0	2.2	0.4	0.5	-1.2	0.1	1.5	1.3
Osteoarthritis (self-reported)	0.4	0.5	2.0	-0.1	0.6	0.8	-1.4	0.4	0.1
Medication: Aspirin	0.6	0.8	3.0	0.7	1.7	-0.2	0.1	0.4	1.0
Medication: Gliclazide	0.6	0.7	2.0	0.2	0.6	-1.4	-0.9	0.4	0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.6	-0.7	-0.0	-0.4	-0.6	0.4
Smoking status: Current	1.1	1.7	5.9	-1.0	-1.5	-2.4	0.5	0.9	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	7.0	-0.5	0.8	0.8	-2.6	1.0	0.8
Whole body water mass	0.6	3.6	10.1	-2.1	-3.2	-0.7	0.3	0.3	-2.5
Leg predicted mass (right)	0.6	3.1	8.0	-1.8	-2.5	-0.9	0.6	0.3	-2.8
Arm fat mass (left)	0.8	3.2	5.8	-0.4	-2.1	-0.6	2.4	2.1	-2.1
Number of self-reported non-cancer illnesses	0.7	1.2	2.3	0.8	1.5	0.5	1.1	1.5	0.8
Average weekly champagne plus white wine intake	0.3	0.4	1.0	0.2	0.5	-0.2	-0.6	-0.7	-1.0
Miserableness	0.7	1.2	5.1	-0.5	-0.8	0.5	-0.5	0.8	-2.2
Guilty feelings	0.3	0.4	1.1	0.6	-0.1	0.2	0.5	0.9	-1.1
Wears glasses or contact lenses	0.5	0.6	1.8	-0.5	-0.9	0.7	-1.4	0.3	0.5
Ever taken oral contraceptive pill	1.3	1.5	3.2	1.5	1.1	-0.4	1.8	-1.1	-0.9
Hearing aid user	0.8	0.9	1.4	1.0	1.0	0.3	0.9	0.9	-1.2
Mother’s age at death	0.4	0.5	1.3	0.6	0.4	0.1	-1.2	-0.8	0.4
Financial situation satisfaction	1.2	1.5	3.9	2.0	1.3	1.1	1.2	-0.5	0.7
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.2	-0.9	-1.5	-0.8	-0.4	-1.8	0.8
Commuting to job workplace: Public transport	0.8	0.9	2.8	-0.5	-0.4	-1.7	-0.4	-1.0	-1.1
Eye problems/disorders: Glaucoma	0.4	0.5	2.5	0.3	-1.6	-0.3	0.4	-0.1	-0.3
Medication: Blood pressure	1.5	2.8	9.6	1.4	3.1	0.2	1.8	0.6	1.3
Pain type(s) experienced in last month: Hip pain	0.4	0.4	1.7	0.9	0.0	0.3	1.3	-0.1	0.4
Supplements: Fish oil (including cod liver oil)	2.6	3.4	9.0	-2.2	0.4	-1.2	-3.0	0.8	2.0
High cholesterol (Self-reported)	0.3	0.6	1.3	0.1	1.0	-0.9	0.2	0.5	1.1
Medication: Bendroflumethiazide	1.3	2.0	6.1	1.4	2.5	0.6	0.8	0.8	1.6
Medication: Paracetamol	2.4	3.8	8.2	2.9	1.4	2.2	2.5	-0.4	-1.0
Medication: Lisinopril	0.9	1.2	6.6	-0.0	2.6	-0.1	-0.3	0.5	0.5
Medication: Atorvastatin	0.2	0.3	1.1	0.2	0.5	0.4	-0.3	-1.0	0.2
Illnesses of father: High blood pressure	2.0	2.4	4.6	2.1	2.0	0.8	2.0	0.1	1.2
Alcohol drinker status: Never	0.6	0.7	1.7	-0.1	-0.1	1.0	1.1	0.6	-1.3
Ever smoked	0.5	0.9	1.9	-1.2	-1.4	-0.5	-0.1	-1.3	0.2
Basal metabolic rate	0.7	3.7	10.2	-1.9	-3.2	-0.6	0.7	0.6	-2.7
Leg fat percentage (left)	1.0	3.7	9.4	1.8	-0.8	0.7	3.1	2.9	-0.4
Arm fat-free mass (left)	0.6	3.1	10.8	-1.5	-3.3	-0.3	0.6	1.1	-2.0
Number of operations (self-reported)	0.4	0.6	2.9	-0.5	-0.3	-0.3	0.1	-0.2	-1.7
Average weekly beer plus cider intake	0.8	1.2	3.0	-0.6	-0.5	1.7	-1.4	0.2	1.2
Irritability	0.1	0.2	0.6	-0.2	0.0	0.8	0.4	-0.5	0.5
Risk taking	0.5	0.7	2.6	0.0	-1.6	-1.0	-0.0	0.6	-0.3
Ever had prostate specific antigen (PSA) test	1.5	1.8	3.9	1.1	-1.4	1.0	2.0	0.6	-1.4
Fractured/broken bones in last 5 years	2.2	2.8	9.7	0.6	-0.7	1.2	1.3	-1.8	-3.1
Age started oral contraceptive pill	1.2	1.5	7.0	0.8	0.6	-0.3	0.3	1.0	2.6
Diastolic blood pressure, automated reading	1.4	4.2	7.5	2.5	0.8	2.3	-0.4	2.3	2.7
Ever depressed for a whole week	1.2	1.5	2.9	1.5	1.6	-0.3	1.7	-0.8	0.8
Unable to work because of sickness or disability	1.3	1.7	2.8	-1.3	-1.6	-1.7	-0.9	1.6	-0.1
Commuting to job workplace: Cycle	2.0	2.4	10.8	0.2	1.0	1.4	0.3	-3.3	-0.7
Myopia	1.6	2.3	6.0	1.8	2.4	2.0	-0.4	0.4	0.5
Vascular/heart problems diagnosed by doctor	1.6	4.4	11.4	-1.7	-3.1	-0.8	-0.9	-1.0	-3.4
Cholesterol lowering medication	0.7	1.1	2.9	0.0	1.7	0.0	-0.2	1.7	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	5.5	1.1	1.4	1.3	2.4	-0.5	-0.8
Pain experienced in last month	0.7	1.2	3.4	-1.1	0.6	-1.9	-0.7	-1.2	0.6
Supplements: Calcium	2.1	2.3	5.9	-0.9	-0.1	-1.4	-2.0	1.1	2.4
Basal cell carcinoma (self-reported)	0.2	0.3	0.9	0.1	0.0	0.9	-0.6	-0.5	-0.2
Heart attack/myocardial infarction (self-reported)	1.4	1.8	8.4	0.8	0.6	0.2	2.9	-0.1	1.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.6	1.6	0.7	0.2	1.2	0.8	-1.2
Heart disease (siblings)	0.5	0.6	2.5	-0.5	0.2	-0.7	-0.4	0.6	1.6
Alcohol drinker status: Previous	0.9	1.1	2.7	0.4	0.0	-1.0	-1.0	1.3	-1.6
Pack years of smoking	1.1	1.6	3.6	-1.9	-0.6	-1.4	-1.2	1.3	0.5
Impedance of whole body	0.2	0.9	3.0	0.6	1.1	0.1	0.1	-1.7	0.7
Leg fat mass (left)	0.8	2.9	6.5	0.4	-1.9	-0.1	2.6	2.4	-1.4
Arm predicted mass (left)	0.8	3.8	13.5	-1.8	-3.7	-0.6	0.5	1.1	-2.1