Hub : Genes

PINK1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0680	0.0230	3.1e-04	0.033	0.020	0.021	0.021	0.025	6.2e-05	1.5e-03	1.2e-03	1.1e-03	4.4e-04
2	GTEx	Adrenal Gland	0.2205	0.0822	8.9e-03	0.146	NA	0.063	NA	0.090	6.4e-06	NA	2.8e-03	NA	3.9e-04
3	GTEx	Cells Transformed fibroblasts	0.2480	0.0650	2.9e-06	0.029	NA	0.032	NA	0.039	2.8e-03	NA	1.7e-03	NA	6.4e-04
4	GTEx	Esophagus Mucosa	0.1150	0.0380	1.0e-03	0.068	NA	0.035	NA	0.067	2.5e-05	NA	2.0e-03	NA	2.8e-05
5	GTEx	Muscle Skeletal	0.2978	0.0488	1.1e-14	0.273	NA	0.292	NA	0.299	8.8e-27	NA	6.1e-29	NA	1.1e-29
6	GTEx	Skin Sun Exposed Lower leg	0.1990	0.0460	2.6e-07	0.100	NA	0.126	NA	0.118	1.2e-08	NA	1.3e-10	NA	5.6e-10
7	NTR	Blood	0.0233	0.0091	1.3e-03	0.001	0.005	0.005	0.006	0.005	1.7e-01	9.7e-03	7.2e-03	2.7e-03	8.6e-03
8	ROSMAP	Brain Pre-frontal Cortex	0.2597	0.0404	0.0e+00	0.218	0.239	0.257	0.259	0.261	1.4e-27	2.3e-30	7.7e-33	3.3e-33	2.2e-33
9	YFS	Blood	0.1256	0.0250	1.3e-15	0.027	0.064	0.070	0.074	0.056	3.1e-09	4.1e-20	5.0e-22	3.8e-23	8.9e-18
10	TCGA	Breast Invasive Carcinoma	0.0182	0.0100	3.4e-03	0.005	0.007	0.002	NA	0.004	2.5e-02	1.2e-02	1.1e-01	NA	5.3e-02
11	TCGA	Liver Hepatocellular Carcinoma	0.0820	0.0400	3.6e-03	0.043	0.041	0.014	NA	0.021	4.4e-03	5.3e-03	6.7e-02	NA	3.4e-02
12	TCGA	Rectum Adenocarcinoma	0.3820	0.1310	5.9e-03	0.050	0.083	0.048	NA	0.104	2.6e-02	5.5e-03	2.8e-02	NA	2.1e-03
13	TCGA	Thyroid Carcinoma	0.1160	0.0420	6.9e-08	0.045	0.094	0.067	NA	0.080	3.3e-05	2.0e-09	4.4e-07	NA	3.3e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.1	0.1	0.6	-0.1	-0.1	0.4	0.6	0.0	0.0	0.8	0.2	-0.8	0.1	0.3	0.4	0.1
Bipolar Disorder or Schizophrenia	0.2	0.4	2.2	-0.1	0.4	-0.1	0.1	0.4	-1.5	0.5	0.5	-0.7	-0.1	0.2	1.2	0.5
Depressed Affect (Nagel 2018)	0.3	0.6	2.2	-0.6	0.9	-0.5	0.7	0.9	0.2	0.7	1.0	0.1	0.6	0.9	0.0	1.5
Depression (Nagel 2018)	0.8	1.1	3.0	-1.3	0.8	-0.4	1.7	0.7	1.1	-0.4	0.9	0.8	0.9	1.6	0.3	1.7
Intelligence (Savage-Jansen 2018)	0.4	1.2	4.0	0.7	-1.1	1.0	-0.5	-1.2	-0.6	-0.7	-1.5	-0.4	-1.1	-1.7	-0.5	-2.0
Neuroticism (Nagel 2018)	0.0	0.1	0.7	-0.8	-0.4	0.4	0.4	-0.2	-0.1	-0.4	0.1	-0.1	0.1	-0.3	0.1	-0.2
Schizophrenia (2018)	0.3	0.5	3.6	-0.0	0.6	-0.4	-0.4	0.5	-1.9	0.0	0.5	-0.3	-0.3	-0.1	1.3	0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	2.1	0.5	0.5	-0.8	-0.6	0.4	-1.4	-0.9	0.3	-0.2	-0.4	-0.1	-0.6	0.2
Worry (Nagel 2018)	0.1	0.3	0.8	-0.8	0.4	0.2	0.5	0.5	-0.0	-0.7	0.9	0.2	0.5	0.5	0.4	0.4
Alzheimer’s Disease (in mother)	0.2	0.2	2.0	-0.2	0.0	0.4	-0.5	0.1	-0.5	0.0	0.3	0.1	0.2	-0.2	1.4	-0.3
Alzheimer’s Disease (in father)	2.0	2.1	6.4	0.6	0.9	-2.3	-2.5	0.8	-2.2	-0.8	0.4	-2.0	-1.6	-0.2	-1.2	0.4
Alzheimer’s Disease (including proxy)	0.7	1.1	4.9	0.2	0.0	-0.6	-2.1	0.0	-2.2	-0.6	-0.1	-1.4	-0.8	-0.8	0.1	-0.5
Crohns Disease (2017)	0.1	0.2	1.6	0.0	0.3	0.1	-0.1	0.2	-1.3	0.2	0.2	-0.0	0.3	0.0	-0.3	0.4
Irritable Bowel Disease (IBD)	0.1	0.4	1.3	0.4	0.9	-0.8	-0.7	0.8	-1.1	0.3	0.5	-0.1	-0.1	-0.2	-0.0	0.5
Ulcerative Colitis (UC)	0.1	0.1	0.3	0.3	0.5	-0.6	-0.6	0.4	-0.5	-0.0	0.2	-0.2	-0.1	-0.4	0.3	0.3
Major Depression (MDD)	0.8	0.9	2.8	0.7	1.7	-1.0	0.1	1.5	-1.0	0.7	0.9	-0.6	-1.0	-0.3	0.2	1.3
Reaction Time	0.5	1.0	3.6	-1.2	0.3	0.2	1.2	0.6	0.6	0.3	1.2	0.4	1.8	1.9	0.7	0.8
Verbal and Numeric Reasoning (VNR)	0.7	1.6	5.9	1.1	-0.6	0.4	-0.8	-0.8	-1.0	-0.8	-1.5	-0.7	-1.6	-2.4	-0.5	-2.3
Breast Cancer	1.9	4.6	14.8	1.5	-2.4	1.0	-1.1	-2.6	-0.6	-0.2	-2.9	-0.2	-1.6	-2.6	-3.9	-3.3
Ovarian Cancer	1.1	1.5	2.7	1.2	-1.5	1.5	0.5	-1.3	0.7	1.5	-1.3	0.8	-0.3	-1.6	1.6	-0.9
Prostate Cancer	0.7	1.0	3.6	-1.2	-1.4	1.9	0.6	-1.4	-0.2	-1.4	-0.9	-0.3	-0.0	-0.3	0.3	-0.8
Age at First Birth	0.6	0.8	2.2	-0.8	0.8	-0.6	0.6	0.9	0.2	-0.0	1.3	-0.4	1.2	1.5	0.7	1.2
Bipolar Disorder (2011)	0.4	0.4	1.5	-0.7	0.8	0.3	1.2	0.7	0.1	0.2	0.5	0.0	0.6	1.0	0.2	0.9
Body Mass Index (BMI) (2010)	0.3	0.4	2.0	-1.4	0.1	0.3	-0.6	-0.1	-0.6	-1.0	0.4	-0.7	0.6	0.4	-0.3	-0.0
Coronary Artery Disease (CAD)	1.2	1.4	5.1	0.3	-0.4	-0.6	-1.9	-0.3	-1.6	-1.6	-0.2	-2.2	-1.1	-1.2	-0.7	-1.0
Crohns Disease (2012)	1.2	2.0	5.1	-1.9	0.9	0.6	1.2	1.2	0.8	-1.3	1.8	0.7	2.2	2.1	0.7	1.6
Mean Putamen Volume	0.3	0.4	1.0	-0.9	0.2	0.2	1.0	0.2	0.9	-0.1	0.3	0.8	0.8	0.7	-0.6	0.2
Fasting Glucose	0.8	0.9	2.6	1.6	-1.0	1.3	0.1	-1.1	-0.5	0.2	-1.2	0.6	-0.6	-1.4	0.8	-0.9
HbA1C	0.9	1.0	3.9	2.0	0.4	-0.8	-1.5	-0.0	-1.7	0.8	-0.3	-0.3	-1.2	-1.0	-0.1	-0.4
HDL Cholesterol	1.5	2.5	7.2	-1.5	-0.9	2.1	2.7	-0.7	2.3	0.2	-0.0	1.5	2.0	1.0	2.1	0.3
LDL Cholesterol	0.6	1.0	2.0	0.5	0.7	-1.3	-1.2	0.5	-1.4	-1.1	0.2	-1.3	-1.2	-0.6	-1.3	0.0
Lupus	0.4	0.7	1.8	-0.8	0.3	0.1	1.0	0.5	1.2	-0.0	1.1	-0.0	1.2	1.3	0.3	1.0
Neuroticism (2016)	0.3	0.5	1.7	1.2	0.7	-1.3	0.1	0.6	-0.6	0.9	0.3	0.6	-0.3	-0.0	-0.6	0.4
Primary Biliary Cirrhosis	2.8	4.0	12.2	-1.4	0.7	0.8	3.0	0.7	3.5	-0.0	1.4	2.4	2.6	2.5	1.8	1.7
Rheumatoid Arthritis	0.6	0.8	2.5	0.6	1.1	-1.6	-1.3	1.0	-1.1	-0.3	0.7	-0.0	-0.7	0.0	-0.5	0.7
Schizophrenia (2014)	0.2	0.5	1.3	0.3	0.5	0.2	1.1	0.4	0.1	0.9	0.3	1.1	0.6	0.6	0.9	0.5
Triglycerides	1.1	1.8	5.4	-0.4	-0.9	-0.1	-1.3	-1.2	-1.2	-2.3	-1.3	-1.2	-1.1	-1.0	-2.3	-1.0
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.4	0.1	-0.2	1.2	0.9	-0.3	-0.2	1.0	-0.2	1.1	0.4	-0.2	-0.7	-0.4
Ulcerative Colitis	0.5	0.7	1.3	0.0	1.0	-0.4	0.7	1.0	1.0	0.3	1.1	1.0	1.1	1.1	0.2	0.5
Blood Eosinophil Count	0.1	0.8	3.6	-1.7	-0.5	0.9	0.4	-0.6	0.3	-1.9	-0.2	-0.2	0.9	-0.1	-0.9	-0.5
Blood Platelet Count	1.0	11.2	31.6	0.7	-4.4	3.8	0.1	-5.0	-0.5	-2.3	-5.6	0.1	-2.2	-4.3	-1.8	-4.8
Blood Red Count	1.0	9.8	26.1	-3.3	-2.7	5.1	4.5	-2.7	3.9	-2.6	-1.8	3.9	3.3	0.6	0.6	-1.9
Blood White Count	0.2	1.3	3.8	1.1	0.1	-1.0	-1.9	-0.4	-0.8	-0.1	-1.4	0.2	-1.9	-1.5	-1.5	-0.6
Heel T-Score	0.6	4.8	11.9	-1.8	2.7	-2.8	-0.7	2.8	-0.2	-0.8	3.2	-1.7	1.2	3.0	0.4	3.5
BMI	0.1	0.7	1.9	-1.4	-0.1	1.0	0.8	-0.2	0.1	0.8	0.1	1.0	1.4	0.8	-1.3	0.2
Height	0.4	8.4	24.7	-1.9	2.6	-2.1	1.4	3.3	1.9	3.2	4.6	0.4	3.0	5.0	2.3	2.7
Waist Hip Ratio (WHR)	0.4	2.0	7.3	-2.5	-1.3	2.0	1.0	-1.3	-0.5	-2.7	-0.8	-1.0	0.8	0.1	-0.2	-1.1
Systolic Blood Pressure	0.4	1.9	5.2	0.1	2.3	-1.9	-0.3	2.2	-1.3	-1.5	1.5	-0.8	-1.1	-0.1	0.6	1.7
Smoking Status	0.9	2.1	8.5	1.5	-1.7	1.1	-0.7	-1.7	0.0	2.9	-1.9	1.1	-0.2	-1.1	0.0	-1.8
Allergy or Eczema	0.5	1.3	2.8	-0.3	-1.3	1.4	0.4	-1.4	1.7	-0.4	-0.9	1.4	1.0	0.1	-1.6	-1.3
Cardiovascular Disease	0.3	0.9	2.3	-0.6	1.4	-1.5	-0.7	1.3	-1.0	-1.1	0.9	-0.9	-0.6	0.2	-0.3	1.0
Hypothyroidism (self reported)	0.6	1.3	6.2	-0.4	0.4	-1.4	-1.6	0.7	-0.9	-1.3	1.2	-2.5	0.4	0.4	-0.6	0.7
Respiratory disease	0.5	1.2	3.4	-1.3	-0.8	1.3	1.2	-0.8	1.6	0.1	-0.1	1.3	1.9	1.0	0.8	0.3
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.8	0.3	-1.5	0.8	-0.4	-1.5	-1.1	0.2	-1.7	-0.8	-0.6	-0.8	0.2	-1.2
Lung FEV1/FVC ratio	0.2	0.9	4.5	-1.1	-0.5	1.5	0.5	-0.3	-0.5	-2.1	0.2	-0.6	1.0	-0.6	1.3	-0.3
Lung FVC	0.7	3.7	11.7	1.3	-1.9	1.6	0.8	-2.5	0.8	-1.1	-3.4	1.1	-1.6	-2.3	-1.8	-2.6
Neuroticism	0.1	0.4	1.2	-1.1	-0.0	0.2	0.7	0.1	0.0	-1.1	0.5	-0.6	0.4	0.6	0.5	0.6
Chronotype (morning person)	0.4	0.9	6.3	0.6	-0.6	0.4	0.0	-0.9	0.1	2.5	-1.3	0.9	-0.3	-0.1	-0.3	-0.7
Hair Pigment	0.0	0.8	4.5	0.0	-0.3	0.3	0.4	-0.2	1.0	0.3	0.2	0.6	1.6	0.7	2.1	0.5
Tanning	0.1	0.8	3.5	1.4	-0.4	0.7	0.5	-0.3	0.4	1.4	-0.5	1.9	0.1	-0.4	1.2	-0.2
Hand grip strength (left)	0.2	0.4	1.7	0.7	0.7	-0.7	0.0	0.8	-0.4	1.3	0.8	-0.2	-0.3	-0.1	0.5	0.5
Number of treatments/medications taken	0.9	1.7	4.8	0.5	2.2	-1.7	-0.5	1.8	-1.3	0.3	0.8	-0.1	-1.6	-0.6	-1.5	1.7
Average weekly spirits intake	0.4	0.5	2.9	-0.1	0.2	0.7	1.2	0.2	0.6	0.4	0.1	1.7	0.9	0.4	-0.5	0.5
Sensitivity / hurt feelings	0.5	0.9	3.1	0.3	-1.4	0.8	-0.6	-1.6	-0.3	0.1	-1.5	0.0	-0.4	-0.8	-0.4	-1.8
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.7	-0.7	1.0	-0.5	1.1	0.8	-0.4	-0.9	0.9	0.0	0.1	1.2	-0.7	1.6
Hearing difficulty/problems: Yes	0.2	0.2	0.6	-0.0	-0.7	0.8	-0.5	-0.5	0.2	-0.7	-0.2	-0.4	0.2	-0.5	0.7	-0.4
Relative age of first facial hair	0.4	0.9	2.7	-0.9	-1.3	1.1	0.6	-1.1	1.0	1.1	-0.9	0.3	0.4	-0.5	-0.4	-1.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	-0.8	-0.3	0.7	0.6	-0.4	0.6	-0.6	-0.3	-0.4	0.5	0.2	0.1	0.3
Ever used hormone-replacement therapy (HRT)	0.9	1.1	4.0	2.0	0.8	-0.9	-0.2	0.4	0.4	1.2	-0.7	1.1	-1.7	-0.9	-1.4	0.3
Ever had hysterectomy (womb removed)	0.8	0.9	3.3	-1.3	-0.7	0.6	-0.8	-0.9	-0.7	-1.8	-0.7	-1.2	-0.3	-0.6	0.3	-1.1
Systolic blood pressure, automated reading	0.1	0.4	1.3	-0.5	0.8	0.1	1.1	0.6	0.2	-1.1	0.2	0.7	0.0	0.4	-0.2	0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.9	-0.4	0.0	-0.0	0.1	0.0	0.0	-0.7	0.2	-0.1	0.5	0.5	1.4	0.8
Angina	1.2	1.6	4.3	0.8	0.2	-1.0	-1.9	-0.1	-2.1	-1.1	-0.6	-1.8	-1.6	-0.9	-1.7	0.1
Medication for hormone replacement therapy	0.3	0.3	0.9	-0.2	0.5	-0.5	-0.9	0.4	-0.9	-0.2	0.3	-0.1	-0.7	-0.5	0.4	-0.5
Vitamin and mineral supplements	0.2	0.3	2.2	-0.1	-0.4	0.2	-0.2	-0.5	0.3	-0.5	-0.4	-0.2	-0.0	-0.1	-1.5	-0.8
Supplements: Zinc	0.1	0.2	0.4	-0.5	-0.6	0.3	0.2	-0.7	0.0	-0.2	-0.6	-0.3	0.1	0.3	-0.2	-0.4
Medication: Co-codamol	0.3	0.3	0.8	0.6	0.5	-0.2	0.7	0.3	-0.1	0.3	-0.4	0.5	-0.8	-0.5	-0.9	0.8
Medication: Metformin	2.1	2.9	7.7	0.0	-2.8	2.2	-0.5	-2.7	-0.5	-0.5	-2.5	-0.8	-0.7	-1.8	-0.3	-2.6
Diabetes (father)	1.1	1.3	3.0	0.5	-1.4	0.8	-1.0	-1.5	-0.9	-0.9	-1.7	-0.9	-1.1	-1.6	0.5	-1.3
Diabetes (mother)	1.5	1.9	6.8	1.1	-0.4	1.3	2.2	-0.3	2.6	1.5	-0.5	2.5	0.4	-0.1	1.1	0.3
Severe depression (siblings)	0.8	0.9	3.4	-0.5	-0.3	0.9	1.7	-0.2	1.9	-0.7	0.0	1.2	1.1	0.9	0.7	0.3
Pack years adult smoking proportion	0.4	0.7	3.4	-0.6	-0.6	0.4	-0.7	-0.5	-1.5	0.3	-0.2	-1.8	0.3	-0.1	1.2	-0.1
Impedance of leg (right)	0.3	1.2	4.2	2.0	0.2	-1.0	-1.3	0.0	-1.3	0.4	-0.8	-0.6	-1.9	-1.0	-1.2	-0.1
Leg fat-free mass (left)	0.4	2.4	9.1	-3.0	-0.1	0.8	1.4	0.2	0.9	0.1	1.6	0.2	2.7	2.1	2.0	0.3
Trunk fat percentage	0.3	1.1	3.6	-0.6	-1.5	1.9	1.0	-1.3	0.9	0.6	-0.7	1.2	1.5	-0.1	0.6	-0.8
Hand grip strength (right)	0.3	0.8	1.9	0.4	1.2	-0.6	0.3	1.3	-0.7	1.2	1.4	0.2	0.1	0.4	1.0	0.9
Townsend deprivation index at recruitment	1.0	1.3	3.2	1.8	0.5	-1.2	-1.5	0.5	-1.4	1.6	0.1	-1.2	-1.3	-1.2	1.1	0.2
Current tobacco smoking	0.2	0.2	1.4	0.5	-0.6	-0.1	-0.0	-0.6	0.3	1.2	-0.6	0.5	-0.1	-0.0	0.1	-0.2
Average weekly fortified wine intake	0.2	0.2	0.8	0.5	0.1	-0.0	-0.5	-0.1	0.6	0.2	-0.5	-0.2	-0.8	-0.9	-0.5	-0.2
Maternal smoking around birth	0.2	0.3	2.2	-0.6	-0.2	0.3	0.2	-0.2	-0.5	-0.0	-0.1	-0.5	-0.4	-0.3	-1.5	-0.3
Fed-up feelings	1.4	2.6	8.5	-0.4	2.6	-2.1	0.2	2.5	-0.2	0.7	2.3	-0.2	-0.1	1.2	0.5	2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.7	-1.5	0.7	0.1	1.9	0.6	0.9	-0.2	0.9	1.3	1.3	1.5	-0.0	1.5
Relative age voice broke	1.0	1.6	4.9	-2.0	0.3	1.0	2.0	0.7	0.8	0.0	1.4	0.4	2.2	1.3	1.2	0.5
Taking other prescription medications	1.3	2.0	5.3	1.6	2.1	-1.7	0.1	1.9	-0.3	0.5	1.1	0.7	-1.2	-0.1	-2.3	2.0
Age when periods started (menarche)	0.7	1.7	4.5	1.3	-1.7	0.9	-1.1	-1.5	-0.8	1.1	-1.7	-0.4	-0.7	-2.1	0.4	-1.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	-1.2	0.8	-0.0	0.8	0.7	0.3	-0.2	0.9	0.7	0.3	0.3	-0.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	6.1	-1.7	1.5	-1.3	-0.3	1.7	-0.9	-0.8	2.5	-1.2	1.4	1.9	1.5	1.6
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	5.9	-2.4	-0.3	-0.0	-0.5	-0.2	-0.5	-1.6	0.4	-1.1	0.5	0.5	-0.1	-0.6
Qualifications: CSEs or equivalent	1.1	1.4	3.5	0.3	1.5	-1.7	-1.3	1.4	-1.9	0.1	1.1	-1.0	-1.0	-0.1	1.4	0.9
Serious illness, injury or assault to yourself	0.6	0.7	2.0	0.6	-0.4	1.4	0.6	-0.5	0.1	1.4	-0.8	1.1	0.1	-1.1	0.8	-0.9
High blood pressure	0.2	0.5	2.2	-1.5	0.3	0.1	0.1	0.2	-0.7	-1.4	0.2	-1.1	0.0	-0.2	-0.6	0.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.1	-0.4	-1.3	1.2	-0.3	-1.3	0.7	-0.7	-0.8	0.4	0.3	-0.5	-1.2	-1.4
Multivitamins +/- minerals	0.6	0.8	3.1	-0.4	-0.7	1.1	0.9	-0.7	1.8	0.7	-0.5	0.9	0.5	0.1	1.6	-0.2
Stomach or abdominal pain in last month	0.8	1.0	3.5	-0.1	0.2	0.9	1.9	0.4	1.1	1.0	0.5	1.4	1.6	0.4	1.1	0.2
Supplements: Glucosamine	0.5	0.6	5.7	-0.4	-0.2	0.0	0.0	-0.4	-0.0	-1.0	-0.5	-0.2	-0.6	-0.6	2.4	-0.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.0	-1.1	-0.1	0.6	1.2	-0.1	1.6	-0.8	0.4	1.3	2.0	1.5	-0.1	0.2
Medication: Atenolol	0.3	0.4	1.7	-1.3	-0.4	0.8	-0.2	-0.3	-0.4	-0.9	0.0	-0.5	0.4	-0.4	1.1	-0.2
Medication: Levothyroxine sodium	0.2	0.4	2.4	0.0	0.1	-0.4	-0.6	0.3	-0.3	-0.1	0.7	-1.6	0.4	0.0	-0.6	0.8
Sitting height	0.4	3.2	9.9	-2.0	1.6	-1.4	0.4	2.1	0.9	0.9	3.1	-0.1	1.8	3.1	1.1	1.6
Chronic bronchitis/emphysema (father)	0.3	0.4	1.2	-0.0	-0.3	0.3	0.6	-0.4	0.7	1.0	-0.4	1.1	0.4	0.0	-0.7	-0.8
High blood pressure (mother)	1.1	1.6	5.7	-2.4	0.2	0.4	1.3	0.3	1.4	-0.6	1.1	0.5	2.0	1.7	1.2	1.0
Body mass index (BMI)	0.3	1.2	3.2	-1.5	-0.9	1.7	1.5	-0.9	1.0	0.6	-0.3	1.3	1.8	0.6	0.0	-0.1
Impedance of leg (left)	0.2	1.0	3.6	1.9	-0.3	-0.3	-0.9	-0.4	-1.0	0.7	-1.2	-0.2	-1.7	-1.1	-1.3	-0.3
Leg predicted mass (left)	0.5	2.5	9.5	-3.1	-0.1	0.8	1.4	0.2	0.9	0.1	1.6	0.2	2.7	2.2	2.1	0.3
Trunk fat mass	0.3	1.5	4.5	-1.5	-1.1	1.8	1.5	-0.9	1.2	0.8	-0.1	1.4	2.1	0.8	0.7	-0.4
Waist circumference	0.4	1.5	4.1	-2.0	-0.3	1.3	1.9	-0.3	1.4	0.3	0.2	1.3	2.0	1.3	-0.1	0.2
Number of incorrect matches in round	0.3	0.5	1.7	-0.0	0.7	-0.9	0.8	0.5	0.3	-0.6	0.2	0.3	-0.4	0.8	-0.9	1.3
Past tobacco smoking	0.6	1.1	2.2	-0.8	1.2	-1.4	-0.1	1.1	-0.2	-1.3	1.0	-1.5	-0.4	1.0	-1.0	1.4
Alcohol usually taken with meals	0.8	1.3	3.7	1.5	0.7	-1.6	-1.4	0.4	-1.0	0.1	-0.3	-1.3	-1.9	-1.0	-1.4	-0.3
Nervous feelings	0.8	1.4	4.1	-0.8	1.1	-0.6	0.4	1.4	0.2	-0.1	1.9	0.3	1.6	2.0	1.3	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	3.8	-1.9	0.9	-0.3	1.1	1.0	0.5	-0.8	1.6	-0.6	1.3	2.0	0.3	1.7
Hearing difficulty/problems with background noise	0.9	1.4	4.4	-1.3	0.4	0.1	0.9	0.8	1.2	0.7	1.6	0.5	2.1	1.7	1.8	0.7
Hair/balding pattern: Pattern 2	0.4	0.5	1.8	0.5	-0.2	-0.2	-1.3	-0.3	-0.7	-0.3	-0.4	-0.5	-0.9	-1.1	-0.8	-0.7
Had menopause	0.7	0.8	2.9	1.4	0.6	-1.2	-1.1	0.4	-1.1	0.6	-0.2	-0.7	-1.7	-0.6	-0.6	0.5
Had other major operations	1.7	2.1	4.0	-1.7	1.2	0.3	1.7	1.5	1.9	0.6	2.0	0.4	1.3	1.6	1.1	1.8
Forced vital capacity (FVC)	0.1	0.3	1.4	-0.3	0.4	-0.8	-0.5	0.1	-0.2	-0.2	-0.2	-0.0	-1.0	0.1	-1.2	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	7.4	-2.7	0.9	-0.6	0.2	1.1	-0.5	-1.3	2.2	-1.1	2.0	2.4	0.8	1.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.7	1.5	-0.4	0.6	0.4	-0.7	-0.4	0.5	-1.4	1.1	-1.6	-1.6	-1.1	-0.8
Qualifications: None of the above	0.6	1.3	3.7	-1.2	1.2	-0.3	0.9	1.2	0.1	0.4	1.4	0.4	1.3	1.9	-0.2	1.9
Financial difficulties in last 2 years	0.3	0.4	1.0	-0.4	-0.1	0.4	1.0	-0.1	0.4	0.2	0.1	0.9	0.8	0.9	0.9	0.6
Mouth/teeth dental problems	0.7	1.1	2.4	0.8	1.4	-1.4	-0.9	1.5	-1.5	0.0	1.1	-0.6	-0.7	0.1	1.0	1.0
Heart attack	0.4	0.6	2.6	0.3	0.1	-0.8	-1.6	0.1	-1.0	-0.9	0.1	-1.0	-0.9	-0.6	0.1	-0.1
Allergy	0.4	1.0	3.3	0.9	0.8	-1.3	-0.9	0.8	-1.8	0.4	0.3	-1.3	-1.4	-0.6	0.9	0.6
Pain all over the body in last month	0.3	0.4	1.8	-0.6	0.1	0.6	0.5	0.3	0.0	0.2	0.6	0.2	1.3	1.2	0.2	0.1
Diabetes (self-reported)	1.6	2.4	6.7	-0.3	-2.6	2.2	-0.2	-2.5	-0.3	-0.7	-2.2	-0.6	-0.0	-1.4	1.1	-2.2
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	8.3	-0.7	-2.3	2.9	0.9	-2.2	0.3	0.5	-1.5	-0.4	1.2	-0.2	-0.4	-1.6
Medication: Ramipril	0.5	0.7	1.6	0.4	-0.6	0.3	-1.1	-0.7	-1.0	-0.2	-1.1	-1.1	-1.0	-1.2	-0.3	-0.8
Medication: Simvastatin	0.3	0.5	3.8	0.6	0.4	-0.6	-0.1	0.2	0.0	0.2	-0.3	0.4	-0.7	-0.5	-1.9	-0.5
Fluid intelligence score	0.8	1.7	4.8	1.8	-0.4	-0.3	-1.5	-0.7	-0.8	-0.3	-1.6	-0.4	-1.9	-2.2	-0.5	-1.7
Illnesses of siblings	0.1	0.2	0.7	0.4	0.1	-0.0	0.1	0.2	0.7	0.8	0.2	0.7	0.3	0.5	-0.3	-0.1
Neuroticism score	0.3	0.6	2.2	-1.0	-0.9	0.9	0.0	-0.8	-0.7	-1.5	-0.3	-1.0	0.3	0.1	-0.4	-0.4
Weight	0.4	2.2	7.0	-2.3	-0.0	1.0	1.7	0.2	1.4	1.0	1.2	1.3	2.6	2.1	1.0	0.6
Impedance of arm (right)	0.2	0.9	3.5	0.6	-0.8	-0.0	-1.2	-0.5	-0.9	-1.8	-0.3	-1.9	-0.5	-0.8	0.0	-0.7
Arm fat percentage (right)	0.2	0.7	2.2	-1.3	-1.0	1.5	0.9	-0.8	0.7	0.1	-0.2	0.5	1.4	0.0	-0.0	-0.4
Trunk fat-free mass	0.9	5.0	12.8	-3.3	1.3	-0.0	2.2	1.6	1.9	1.2	2.8	1.3	3.2	3.6	2.0	1.7
Hip circumference	0.3	1.2	3.1	-1.4	0.2	0.3	1.1	0.3	1.5	1.3	0.9	1.3	1.8	1.6	0.3	0.7
Time employed in main current job	0.9	1.0	2.3	-0.7	-1.3	1.4	-0.1	-1.3	-0.3	-1.5	-1.1	-0.4	0.0	-1.1	-0.6	-1.5
Alcohol intake versus 10 years previously	0.9	1.3	4.3	1.7	-0.5	-0.0	-1.0	-0.8	-0.6	1.0	-1.5	-0.3	-1.8	-2.1	0.3	-0.8
Father’s age at death	0.5	0.7	3.2	-0.8	-0.2	0.7	0.9	-0.3	1.8	0.3	0.1	0.8	1.2	0.8	-0.6	-0.2
Worrier / anxious feelings	0.6	1.1	3.0	-0.2	-0.7	0.3	-1.0	-0.7	-1.7	-1.4	-0.6	-1.3	-1.0	-1.1	-1.2	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.7	0.5	-0.0	0.6	0.4	0.0	-0.5	0.5	0.4	0.3	0.3	0.6	0.7
Falls in the last year	2.3	3.1	9.1	1.0	1.8	-0.7	1.8	2.0	2.0	3.0	1.7	2.0	1.0	1.0	1.7	2.0
Hair/balding pattern: Pattern 3	0.3	0.5	2.6	0.3	-0.3	0.5	0.8	-0.3	1.1	-1.6	-0.5	0.3	-0.7	-0.6	0.1	-0.2
Number of live births	0.9	1.2	3.1	-0.8	-0.9	1.8	1.3	-0.9	1.6	-0.8	-0.5	0.9	1.3	0.7	-1.3	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.2	-0.6	0.3	-0.5	-0.5	0.1	-0.8	-1.1	-0.1	-0.6	-0.9	-0.2	-0.7	-0.7
Pulse rate	0.2	0.3	1.3	1.1	-0.5	0.2	0.8	-0.6	0.2	-0.0	-0.9	0.6	-0.5	-0.3	-0.0	0.1
Happiness	1.1	1.3	4.8	0.2	-0.4	1.4	2.2	-0.4	2.0	0.8	-0.5	2.1	0.7	-0.2	-0.2	-0.3
Noisy workplace	1.6	1.9	4.4	0.6	-2.0	1.4	-1.2	-1.8	-0.7	0.3	-1.7	-0.5	-0.7	-2.1	1.2	-2.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.2	-0.2	-1.5	1.8	0.4	-1.3	1.7	-1.1	-0.9	0.3	0.9	-0.6	0.4	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.4	1.0	-0.1	0.7	1.5	-0.2	1.1	0.8	-0.3	1.8	-0.0	0.3	-1.1	0.3
Mouth/teeth dental problems: Dentures	0.8	1.3	3.1	-1.5	-0.1	1.2	1.8	0.0	1.7	1.3	0.5	1.2	1.4	1.0	0.8	0.8
Asthma	0.6	1.2	3.8	-1.9	0.1	0.6	1.5	0.2	1.4	-0.3	0.8	0.7	1.7	1.4	-0.5	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.3	-0.5	0.6	-0.4	-1.2	0.4	-0.5	-0.4	0.1	-0.3	-0.8	-0.5	-1.5	-0.3
Medication: Cholesterol lowering	1.0	1.5	3.8	1.4	-0.4	-0.2	-0.9	-0.7	-1.5	-0.7	-1.3	-0.6	-2.0	-1.8	-1.6	-1.2
Depression (self-reported)	1.3	1.5	3.8	-0.5	-1.7	1.7	0.8	-2.0	0.9	0.4	-2.0	1.1	0.1	-0.5	-0.8	-1.5
Medication: Lansoprazole	2.1	2.3	6.9	1.2	2.5	-1.8	-0.5	2.5	-0.6	1.2	2.0	-0.1	-0.2	0.8	0.4	2.6
Prospective memory result	0.5	0.7	2.1	-1.4	-0.2	0.6	0.7	-0.1	-0.9	-0.7	0.5	-1.3	0.6	0.9	0.5	0.9
Lung cancer (father)	0.5	0.6	1.6	0.3	1.1	-1.3	-0.2	1.0	-0.5	0.9	0.5	-0.3	-0.5	0.7	0.4	1.1
Illnesses of mother	0.5	0.6	1.7	0.2	0.8	-1.1	-0.8	0.8	-0.6	-0.8	0.6	-0.9	-0.9	-0.1	-1.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.8	-0.1	0.2	-0.5	-0.3	0.1	-0.5	-0.9	-0.1	-0.5	-0.8	-0.3	0.0	-0.3
Pulse wave Arterial Stiffness index	0.7	0.8	2.5	0.2	-0.9	1.6	1.2	-1.0	0.4	0.7	-1.1	1.2	-0.2	-0.6	-0.6	-0.4
Impedance of arm (left)	0.2	0.9	2.1	1.2	-0.7	-0.1	-1.4	-0.5	-1.0	-1.3	-0.6	-1.5	-0.8	-1.1	0.3	-0.8
Arm fat mass (right)	0.3	1.4	4.4	-1.9	-0.9	1.7	1.4	-0.8	1.3	0.5	0.1	0.9	2.1	0.9	0.5	-0.1
Trunk predicted mass	0.9	4.9	12.6	-3.3	1.3	-0.0	2.2	1.6	1.9	1.1	2.8	1.3	3.2	3.5	2.0	1.7
Standing height	0.4	4.4	13.0	-2.0	1.9	-1.6	0.6	2.4	0.9	1.2	3.4	0.0	2.1	3.6	2.5	1.8
Length of working week for main job	0.4	0.4	1.7	0.5	0.4	-0.6	-0.4	0.4	-0.3	1.3	0.3	0.4	-0.8	-0.7	1.2	0.1
Exposure to tobacco smoke at home	1.3	1.5	4.8	-1.4	0.3	0.4	1.4	0.3	1.3	0.1	0.9	1.0	2.1	2.2	-1.4	0.4
Breastfed as a baby	1.3	1.6	4.7	1.7	0.8	-1.9	-1.7	0.6	-1.5	0.2	-0.2	-1.0	-2.2	-1.3	-0.6	-0.0
Tense / ‘highly strung’	0.1	0.2	0.7	-0.1	-0.2	0.5	-0.2	-0.1	-0.5	-0.1	0.1	-0.8	0.0	-0.2	-0.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.5	-1.0	-0.7	1.8	1.9	-0.7	0.6	0.5	-0.6	0.8	0.4	-0.0	1.2	0.1
Hair/balding pattern: Pattern 4	0.1	0.4	1.6	0.5	-0.8	0.7	0.6	-0.7	1.3	-0.4	-0.6	0.5	0.3	-0.1	-0.3	-0.1
Birth weight of first child	0.9	1.7	3.6	-0.5	-1.0	-0.1	-1.6	-1.1	-1.9	-1.2	-1.2	-1.6	-1.6	-1.7	-0.3	-1.4
Peak expiratory flow (PEF)	0.2	0.4	1.8	-1.0	-0.4	0.0	-0.6	-0.5	-0.3	-1.3	-0.4	-0.5	-0.2	-0.2	-0.2	-1.0
Pulse wave reflection index	0.4	0.5	3.8	0.2	-0.4	0.7	-0.4	-0.5	-0.7	0.0	-0.6	0.0	-0.1	-0.2	-1.9	-0.6
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.0	-0.3	-1.7	1.2	-0.3	-1.7	-0.2	-0.3	-1.5	-1.1	-0.8	-1.2	-0.1	-1.0
Loud music exposure frequency	1.5	1.7	4.8	-0.9	-2.2	1.5	-0.1	-2.1	0.5	-1.0	-1.8	-0.4	-0.5	-1.1	0.1	-1.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.7	0.7	-0.5	-0.2	-1.2	-0.5	-1.1	-0.9	-0.6	-1.2	-0.8	-1.3	-0.2	-0.9
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.7	0.2	-1.7	1.9	0.4	-1.9	0.7	-1.0	-1.6	1.2	0.4	-0.7	-1.1	-1.4
Blood clot in the leg (DVT)	0.4	0.6	1.6	0.7	-0.9	0.6	0.1	-0.9	-0.2	-0.0	-1.1	-0.1	-0.8	-1.3	-0.3	-1.2
Medication: Paracetamol	1.0	1.7	5.3	-0.8	0.9	0.2	1.8	0.9	1.8	0.9	1.0	2.3	1.7	1.2	0.2	1.2
Headache pain in last month	0.2	0.3	1.3	0.2	0.2	0.3	0.2	0.1	0.7	0.9	-0.3	1.2	0.3	-0.7	0.4	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.2	0.2	-0.3	0.2	0.2	-0.3	1.0	1.1	-0.2	1.1	0.5	0.4	-0.4	-0.1
Glaucoma (self-reported)	1.1	1.3	4.5	0.3	0.2	0.4	1.8	0.4	2.0	1.2	0.5	2.1	1.1	0.8	-0.2	0.6
Gout (self-reported)	0.6	0.8	2.7	-1.4	-0.5	1.0	0.5	0.0	-0.5	-1.1	0.8	-0.8	1.6	0.7	1.1	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.2	0.2	0.7	-1.4	-1.2	0.9	-0.6	-0.9	1.2	-1.8	0.3	0.3	-0.2	1.2
Medication: Amlodipine	0.5	0.6	1.6	-1.3	0.9	-0.5	-0.2	0.9	-1.1	-0.4	0.9	-1.3	0.3	0.3	0.7	0.6
Medication: Ventolin 100micrograms inhaler	1.3	1.6	5.0	-0.1	1.7	-0.6	1.4	1.6	0.9	0.8	1.6	1.1	0.8	1.4	0.7	2.2
Birth weight	0.2	0.3	1.4	-0.8	0.3	-0.4	-0.1	0.4	-0.6	-1.2	0.6	-0.6	0.5	0.5	0.7	0.3
Chronic bronchitis/emphysema (mother)	1.5	1.8	6.4	-0.4	-1.1	1.4	1.7	-1.0	1.3	0.9	-0.5	1.8	2.5	1.7	0.6	-0.0
High blood pressure (siblings)	0.5	0.7	5.0	-2.2	0.2	-0.0	0.5	0.2	-0.2	-1.1	0.6	-0.6	0.6	0.8	-0.3	0.3
Forced vital capacity (FVC), Best measure	0.0	0.2	0.7	-0.2	-0.2	-0.4	-0.4	-0.4	-0.1	-0.2	-0.5	-0.2	-0.8	-0.1	-0.2	-0.8
Body fat percentage	0.3	1.0	3.2	-0.7	-1.3	1.8	1.1	-1.2	0.8	0.7	-0.8	1.2	1.3	-0.1	0.0	-0.6
Leg fat percentage (right)	0.3	1.3	3.1	-0.7	-1.2	1.8	1.5	-1.3	0.9	0.8	-1.1	1.6	1.2	-0.0	-0.8	-0.4
Arm fat-free mass (right)	0.7	3.7	8.9	-2.6	1.0	0.2	2.0	1.2	1.5	1.7	2.1	1.7	2.7	3.0	1.8	1.4
Exposure to tobacco smoke outside home	1.1	1.5	5.3	-1.9	-0.0	0.7	1.3	0.1	0.9	-0.6	1.0	0.1	2.2	2.3	-0.8	0.7
Comparative body size at age 10	0.2	0.4	1.5	-0.0	-0.7	0.5	0.2	-0.7	-1.0	-1.1	-0.8	-1.2	0.0	-0.2	-0.1	0.3
Number of full brothers	2.5	3.1	12.2	-2.2	-0.2	1.4	2.3	0.2	1.8	-1.0	1.4	1.3	3.5	2.7	0.5	0.9
Worry too long after embarrassment	0.8	1.4	3.1	0.1	-1.6	0.5	-1.1	-1.5	-1.3	-1.8	-1.0	-1.4	-0.5	-1.0	-1.0	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	8.1	-0.9	-1.7	2.8	2.4	-1.6	1.8	0.3	-1.0	1.7	1.8	0.1	0.9	-0.7
Wheeze or whistling in the chest in last year	0.1	0.2	1.1	0.7	0.1	-0.1	-0.3	0.1	0.4	1.1	-0.1	0.2	0.3	-0.4	-0.5	0.1
Number of children fathered	0.2	0.2	0.8	-0.2	-0.1	0.3	-0.3	0.1	0.5	-0.6	0.2	-0.2	0.8	0.2	-0.9	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.5	-0.5	-0.2	1.1	1.4	-0.0	0.5	-0.4	0.5	1.1	1.5	0.9	1.6	0.8
Age at first live birth	1.5	2.6	7.1	-0.3	-2.7	1.9	-0.7	-2.5	-0.4	-1.7	-2.1	-1.5	-0.0	-1.5	0.3	-2.2
Pulse wave peak to peak time	0.9	1.0	3.2	-0.4	1.1	-1.8	-1.1	1.3	-0.4	-0.4	1.5	-1.2	0.3	0.9	0.8	0.6
Health satisfaction	0.2	0.2	1.1	0.1	-0.0	0.4	0.7	-0.2	1.1	-0.0	-0.4	0.5	-0.6	-0.6	-0.4	-0.2
Shortness of breath walking on level ground	0.4	0.5	2.6	-1.6	-0.2	0.7	0.4	0.0	-0.0	-0.2	0.8	-0.3	1.4	0.7	0.0	0.5
Qualifications: College or University degree	0.5	1.6	5.2	-0.5	-1.8	1.5	0.2	-1.7	0.9	-1.6	-1.4	-0.4	0.1	-1.0	0.8	-2.3
Eye problems/disorders: None of the above	3.7	4.3	13.0	2.9	-0.2	-1.9	-3.6	-0.4	-2.4	1.0	-1.5	-1.6	-3.1	-2.6	-0.8	-1.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.8	0.9	-1.4	1.2	0.3	-1.5	1.4	1.2	-1.7	0.5	-0.4	-1.1	-0.6	-0.9
Emphysema/chronic bronchitis	0.5	0.5	2.0	0.5	-0.4	0.7	1.1	-0.4	1.1	0.5	-0.4	1.4	0.8	0.4	0.1	-0.0
Medication for pain relief, constipation, heartburn	0.7	1.2	3.3	1.2	-1.1	-0.3	-1.1	-0.9	-1.4	-0.6	-1.0	-1.8	-1.2	-1.0	0.4	-1.1
Neck or shoulder pain in last month	0.1	0.2	1.0	0.1	-0.2	0.2	-0.1	-0.3	-0.4	1.0	-0.4	0.0	0.3	0.1	-0.8	0.1
Medication: Blood pressure	0.4	0.7	2.5	-1.6	0.2	0.5	0.6	0.4	-0.2	-1.2	0.9	-0.9	1.1	0.7	0.7	0.6
Angina (self-reported)	1.1	1.4	3.1	0.9	0.2	-1.0	-1.8	-0.1	-1.7	-1.2	-0.7	-1.5	-1.6	-0.8	-1.7	0.0
Migraine (self-reported)	0.6	0.8	1.6	0.6	-0.9	0.5	-1.3	-0.9	-1.1	-0.5	-0.9	-1.3	-0.5	-1.3	0.1	-0.6
Medication: Ibuprofen	0.8	1.0	2.8	-0.2	0.6	-0.8	-1.6	0.4	-1.4	-0.5	0.0	-0.9	-1.7	-1.1	-1.2	-0.2
Medication: Allopurinol	0.5	0.6	1.9	-0.6	0.3	0.1	0.1	0.7	-0.6	-0.8	1.4	-1.2	1.1	0.7	0.8	0.7
Medication: Omeprazole	1.1	1.3	3.2	-1.1	0.2	0.6	1.7	0.2	1.7	-1.1	0.5	1.8	1.4	1.2	-0.9	0.6
Medication: Seretide 50 evohaler	1.7	1.9	6.1	1.4	-0.7	-0.1	-1.3	-1.0	-0.4	1.7	-1.6	-0.0	-1.2	-1.7	-2.5	-2.0
Mean time to correctly identify matches	0.9	1.6	4.5	-0.6	0.7	0.2	2.1	0.9	1.4	0.5	1.3	1.0	1.9	1.9	0.9	1.5
Heart disease (mother)	2.9	3.5	10.1	1.6	-1.1	-0.0	-2.7	-1.3	-2.8	0.8	-2.0	-1.2	-2.4	-3.2	0.4	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.4	0.7	1.8	-1.4	-0.6	1.6	-0.6	1.3	1.0	0.6	-0.8	0.4	-1.0	1.3
Whole body fat mass	0.3	1.3	3.6	-1.5	-1.0	1.7	1.4	-0.9	1.1	0.9	-0.2	1.3	1.9	0.7	0.3	-0.4
Leg fat mass (right)	0.4	1.4	3.8	-1.5	-0.9	1.7	1.7	-0.9	1.0	0.9	-0.3	1.5	2.0	0.8	-0.2	-0.3
Arm predicted mass (right)	0.7	3.7	8.6	-2.5	0.9	0.3	2.2	1.1	1.6	2.0	2.0	1.8	2.7	2.9	1.9	1.3
Pulse rate, automated reading	1.0	3.3	6.9	1.7	-1.9	2.2	2.4	-2.1	1.7	1.2	-2.6	2.5	0.3	-0.7	-0.3	-1.6
Alcohol intake frequency.	0.2	0.5	3.2	0.3	0.6	-0.3	0.3	0.3	1.2	1.8	-0.1	0.8	0.0	0.2	-0.3	0.9
Comparative height size at age 10	1.9	10.3	30.2	-2.3	2.8	-1.4	2.7	3.2	2.8	1.2	4.4	2.0	3.7	5.5	2.6	4.1
Number of full sisters	1.1	1.3	3.6	1.9	-0.7	-0.4	-1.4	-0.8	-0.9	1.1	-1.2	-0.7	-1.3	-1.8	-0.2	-0.9
Suffer from ‘nerves’	0.9	1.4	3.6	-0.5	0.8	0.5	1.9	1.1	1.6	0.8	1.5	1.6	1.4	0.9	0.7	1.1
Overall health rating	0.5	1.0	3.7	1.5	1.0	-0.6	0.1	0.6	-0.1	1.9	-0.4	1.0	-1.2	-0.8	-1.1	0.9
Chest pain or discomfort	0.9	1.2	3.6	0.4	-1.5	1.3	0.1	-1.7	-0.2	0.7	-1.9	0.3	-0.6	-1.5	-0.2	-1.5
Had major operations	0.8	0.9	2.4	0.9	-1.1	1.2	-0.3	-1.1	-0.4	-0.1	-1.1	0.7	-0.5	-1.6	0.8	-1.2
Age at last live birth	1.8	2.6	7.6	-0.7	-2.7	2.8	0.7	-2.5	1.0	-1.6	-2.0	0.5	1.1	-0.6	0.7	-1.4
Family relationship satisfaction	0.6	0.8	1.9	1.1	1.3	-1.4	-0.2	1.3	-0.4	0.5	0.8	0.0	-1.0	-0.2	0.8	1.0
Leg pain on walking	0.9	1.2	3.2	-0.8	-0.9	1.8	1.5	-0.8	1.7	0.2	-0.2	1.0	1.7	0.5	0.8	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	3.3	-1.3	-1.1	1.8	1.2	-1.0	0.3	-0.7	-0.4	0.9	1.1	0.6	0.4	-0.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.8	-1.3	-0.2	0.9	1.3	-0.2	0.7	-0.7	0.2	0.5	0.7	0.9	0.9	1.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	7.6	-0.7	0.5	-1.5	-2.2	0.8	-1.5	-1.9	1.0	-2.8	-0.7	-0.3	0.2	0.1
Medication: Aspirin	0.3	0.3	1.3	0.1	1.2	-0.8	-0.1	0.9	0.1	0.7	0.6	-0.0	-0.5	-0.0	-0.4	0.6
Supplements: Vitamin C	0.4	0.5	1.1	-0.8	0.6	-0.5	0.3	0.7	-0.5	-0.4	1.0	0.1	0.6	0.9	0.7	1.0
Knee pain experienced in last month	0.2	0.4	1.2	-0.6	-0.9	0.7	0.5	-1.1	-0.2	-0.6	-1.0	0.1	0.1	-0.0	0.5	-0.3
Hypertension (Self-reported)	0.2	0.6	2.4	-1.5	0.4	-0.1	0.1	0.3	-0.8	-1.4	0.3	-1.2	-0.0	-0.1	-0.7	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	6.6	-0.2	2.0	-1.1	0.9	2.1	1.8	1.1	2.3	2.0	1.8	2.6	-0.9	2.0
Illnesses of father: Heart disease	5.5	7.7	16.3	1.4	-1.2	-1.0	-4.0	-1.5	-4.0	-2.5	-2.1	-3.6	-3.2	-3.3	-2.8	-2.9
Illnesses of siblings: Diabetes	0.2	0.3	1.2	-0.4	-0.5	0.6	0.1	-0.4	0.2	-1.1	-0.1	-0.5	0.0	-0.2	1.1	-0.0
Smoking status: Previous	0.6	0.9	2.8	-0.2	-0.9	1.7	0.8	-0.8	0.1	0.5	-0.5	1.6	1.2	-0.1	1.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	7.7	-2.6	1.1	-0.2	0.3	1.3	-0.1	0.4	2.1	-0.3	1.9	2.1	2.8	1.4
Whole body fat-free mass	0.7	4.1	11.2	-3.3	0.7	0.5	2.1	1.0	1.7	0.9	2.3	1.2	3.2	3.1	2.1	1.1
Leg fat-free mass (right)	0.5	2.8	9.7	-3.1	-0.2	1.1	1.7	0.1	1.2	0.3	1.5	0.5	2.8	2.2	2.3	0.3
Arm fat percentage (left)	0.2	0.7	2.4	-1.2	-1.0	1.5	0.9	-0.9	0.7	0.1	-0.3	0.7	1.4	-0.0	0.2	-0.5
Average weekly red wine intake	0.8	1.1	4.4	1.3	-1.0	0.3	-0.5	-1.0	1.3	0.8	-1.3	0.7	-0.3	-1.0	-0.8	-2.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	0.7	-0.4	-0.0	-0.6	-0.4	-0.1	-0.2	-0.4	-0.8	-0.6	-0.9	-0.4	-0.3
Mood swings	0.3	0.5	1.4	-0.5	0.8	-1.0	-1.0	0.8	-1.2	0.4	0.8	-0.8	-0.1	0.3	-0.2	0.5
Loneliness, isolation	0.3	0.3	1.1	-0.9	-0.3	0.5	0.8	-0.4	0.4	-1.1	-0.3	-0.2	0.3	0.4	-0.8	0.2
Long-standing illness, disability or infirmity	0.7	1.1	2.9	1.2	1.6	-1.5	-0.2	1.4	-0.5	1.7	0.6	0.7	-0.7	-0.2	-0.3	1.3
Ever had bowel cancer screening	1.1	1.3	3.0	-1.2	0.9	-0.6	1.1	1.0	1.7	-0.3	1.3	0.6	1.6	1.4	0.2	1.6
Diabetes diagnosed by doctor	1.2	2.0	5.4	-0.5	-2.3	2.0	-0.3	-2.2	-0.5	-1.0	-1.9	-0.9	-0.1	-1.2	0.2	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.9	-1.0	-0.9	1.5	1.4	-0.6	1.1	-0.4	0.1	0.6	1.7	1.2	-0.1	-0.5
Friendships satisfaction	0.4	0.5	1.8	0.8	0.4	0.0	-0.2	0.4	-0.3	-0.9	0.1	-0.2	-1.3	-1.4	0.7	-0.3
Qualifications: nursing, teaching	0.5	0.8	2.9	1.0	-0.1	-0.9	-1.2	-0.4	0.4	-0.2	-1.0	-0.4	-1.7	-1.4	0.3	-0.6
Commuting to job workplace: Walk	1.4	1.5	9.9	3.1	0.3	-0.9	-0.3	0.4	-0.1	2.4	-0.2	0.9	-0.0	-0.1	-1.2	-0.1
Eye problems/disorders: Cataract	2.6	3.0	7.1	-2.3	0.1	1.4	2.7	0.2	2.6	-1.2	0.9	1.8	2.5	2.1	1.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.0	-1.5	-0.2	0.8	1.3	0.1	1.1	-1.5	0.9	0.3	2.2	1.5	-0.1	0.2
Medication for cholesterol	0.8	1.3	4.0	-0.4	-1.0	1.1	1.5	-0.5	1.1	-0.9	0.5	-0.2	2.0	1.5	1.7	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	5.5	-2.4	-0.7	1.7	1.7	-0.8	1.2	-0.8	-0.1	1.2	1.6	1.0	1.0	-0.3
Back pain experienced in last month	0.4	0.5	1.8	0.2	-0.6	0.5	-0.2	-0.8	-0.7	0.6	-1.0	0.2	-0.7	-1.3	-0.6	-0.9
Mineral and other dietary supplements	0.3	0.4	2.1	-0.2	-0.3	0.3	0.6	-0.1	0.8	-0.1	0.3	0.8	1.5	0.7	-0.4	-0.2
Breast cancer (self-reported)	0.4	0.4	2.1	0.3	0.2	-0.2	-0.5	0.4	-0.9	1.0	0.3	-0.5	-0.5	-0.5	1.4	0.4
Asthma (self-reported)	0.5	1.0	3.1	-1.8	-0.1	0.7	1.3	-0.0	1.4	-0.1	0.5	0.8	1.5	1.1	-0.6	0.8
Osteoporosis (self-reported)	0.8	1.0	2.6	1.6	1.0	-1.3	-0.8	0.6	-0.4	1.6	-0.1	0.7	-1.4	-0.6	0.5	0.5
Osteoarthritis (self-reported)	1.6	2.1	4.3	-0.4	2.0	-0.9	1.6	2.1	1.9	0.6	1.8	1.0	0.6	1.4	0.6	2.1
Medication: Aspirin	0.1	0.2	0.6	-0.0	0.8	-0.5	0.1	0.5	0.1	0.4	0.2	0.2	-0.5	-0.0	-0.5	0.4
Medication: Gliclazide	3.2	3.6	9.3	2.0	-1.7	0.4	-1.7	-1.8	-2.1	-0.2	-2.4	-1.8	-2.7	-3.0	-0.1	-2.0
Illnesses of father: None of the above (group 1)	0.7	0.9	3.0	-0.8	-0.2	1.0	1.7	-0.2	1.4	0.9	0.2	1.1	0.5	0.9	1.1	0.6
Smoking status: Current	0.4	0.7	2.7	0.9	-0.9	0.1	-0.2	-1.0	0.5	1.6	-1.1	0.8	-0.4	-0.5	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.5	-0.2	0.2	0.2	0.7	-0.2	0.6	-0.4	-0.5	0.5	-0.2	0.1	-0.4	0.0
Whole body water mass	0.7	4.1	11.2	-3.4	0.8	0.4	2.0	1.1	1.6	0.9	2.3	1.1	3.2	3.1	2.3	1.2
Leg predicted mass (right)	0.5	2.7	9.5	-3.1	-0.2	1.2	1.7	0.1	1.2	0.2	1.4	0.6	2.8	2.2	2.2	0.3
Arm fat mass (left)	0.3	1.4	4.5	-1.9	-0.7	1.5	1.4	-0.6	1.4	0.7	0.2	1.1	2.1	1.0	0.5	-0.0
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	0.1	0.8	-0.7	-0.5	0.6	-0.7	-0.6	0.2	-0.4	-0.6	-0.5	-0.5	0.7
Average weekly champagne plus white wine intake	0.8	1.1	3.0	0.8	-1.1	0.8	-0.2	-1.3	-0.6	0.1	-1.6	-0.1	-1.2	-1.7	-0.8	-1.4
Miserableness	0.6	1.1	3.3	-1.7	-0.0	0.9	1.5	0.1	0.7	0.7	0.8	0.1	1.8	1.4	-0.1	1.1
Guilty feelings	0.4	0.6	1.1	-0.1	-0.9	0.6	-0.7	-0.9	-1.0	-0.8	-0.8	-1.1	-0.7	-0.5	-0.9	-1.0
Wears glasses or contact lenses	1.0	1.1	2.9	0.9	1.5	-1.6	-0.2	1.2	0.1	0.7	0.2	1.4	-1.1	-0.1	-1.7	0.7
Ever taken oral contraceptive pill	1.0	1.1	3.6	1.2	-0.6	-0.5	-1.9	-0.7	-0.8	-0.3	-1.0	0.1	-1.5	-1.5	-0.8	-1.0
Hearing aid user	1.4	1.5	4.0	0.2	-1.9	1.2	0.2	-2.0	1.1	-1.0	-1.9	0.5	-0.4	-0.9	-0.9	-1.7
Mother’s age at death	0.5	0.6	1.9	-0.0	-1.1	1.1	0.3	-1.2	0.1	-0.1	-1.4	-0.2	-0.5	-1.0	0.0	-0.7
Financial situation satisfaction	0.8	1.0	3.6	-1.2	-0.4	1.2	1.8	-0.3	1.1	-1.9	0.0	0.7	0.4	-0.1	1.1	-0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	0.4	-0.4	0.9	0.9	-0.3	1.1	0.1	-0.1	0.9	0.5	-0.2	0.0	-0.3
Commuting to job workplace: Public transport	1.4	1.7	4.6	1.4	-1.7	0.5	-0.7	-1.8	-0.1	0.1	-2.1	0.6	-0.8	-1.6	-0.6	-2.1
Eye problems/disorders: Glaucoma	0.8	1.0	4.2	-0.0	0.3	0.7	2.1	0.4	1.2	0.8	0.7	1.5	1.0	0.9	-1.0	0.6
Medication: Blood pressure	0.6	1.2	4.8	0.3	1.3	-1.5	-1.2	0.8	-0.7	0.5	-0.2	-0.0	-1.6	-1.1	-2.2	0.3
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.1	0.1	-0.6	0.1	-1.2	-0.6	-1.4	-0.8	-0.6	-0.9	-1.0	-1.4	-0.1	-0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.3	0.1	-0.1	0.3	-0.4	-0.4	-0.5	0.2	-0.6	-0.2	-1.1	-0.4	-0.4	-0.3
High cholesterol (Self-reported)	0.2	0.4	1.2	0.4	1.0	-1.1	-0.1	0.8	-0.1	0.5	0.3	0.6	-0.4	0.3	-0.9	0.2
Medication: Bendroflumethiazide	0.2	0.3	2.3	-1.5	0.2	-0.3	-0.3	0.0	0.4	-0.7	0.0	-0.8	0.1	0.1	-0.8	0.2
Medication: Paracetamol	0.9	1.4	4.8	-0.2	1.6	-0.8	1.1	1.4	1.1	1.1	1.1	2.2	0.9	0.8	0.4	1.5
Medication: Lisinopril	0.2	0.3	1.7	0.1	0.1	-0.1	0.5	-0.1	1.3	0.1	-0.5	0.9	-0.4	-0.1	0.2	0.5
Medication: Atorvastatin	0.6	0.8	3.0	0.8	1.4	-1.7	-0.9	0.9	-0.8	-0.3	0.2	-0.4	-0.9	-0.1	0.2	1.1
Illnesses of father: High blood pressure	0.7	0.9	5.0	0.6	0.9	-0.4	1.3	0.9	0.4	0.7	0.5	2.2	0.8	0.6	-0.4	0.9
Alcohol drinker status: Never	2.2	2.6	5.5	-1.9	2.2	-1.4	1.1	2.1	1.1	0.1	2.3	0.5	1.4	2.3	-0.1	1.9
Ever smoked	0.2	0.3	1.0	0.5	-0.9	0.3	-0.5	-0.7	0.0	0.2	-0.4	-0.0	0.1	-0.7	1.0	-0.9
Basal metabolic rate	0.6	3.6	10.2	-3.2	0.5	0.6	1.9	0.8	1.6	0.9	2.1	1.0	3.1	2.9	1.9	1.0
Leg fat percentage (left)	0.5	1.9	5.8	-0.8	-1.7	2.4	1.7	-1.7	0.9	0.8	-1.4	1.8	1.3	-0.2	-0.8	-0.6
Arm fat-free mass (left)	0.7	3.6	8.1	-2.8	0.9	0.3	2.0	1.2	1.6	1.4	2.2	1.3	2.7	2.9	1.8	1.4
Number of operations (self-reported)	1.2	1.8	3.8	-1.1	1.1	0.6	1.8	1.2	1.9	0.4	1.6	1.9	1.6	1.1	0.9	1.4
Average weekly beer plus cider intake	0.9	1.3	2.8	-1.4	-1.7	1.6	-0.6	-1.4	-1.6	-0.8	-0.4	-1.7	0.8	-0.2	0.4	-0.9
Irritability	0.6	1.0	3.4	-1.9	-1.2	1.5	0.4	-1.2	0.1	-1.1	-0.5	-0.3	1.0	0.0	0.6	-1.3
Risk taking	2.0	2.9	6.4	1.3	-1.8	0.9	-1.8	-2.1	-1.6	1.9	-2.5	-0.2	-1.0	-2.1	-0.7	-2.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	3.0	-0.6	-0.2	-0.1	-0.3	-0.3	-0.3	-1.4	-0.3	0.0	-0.0	0.5	-1.7	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-1.1	-0.9	1.1	0.3	-0.8	0.5	-0.8	-0.2	0.3	0.7	0.0	-0.2	-1.0
Age started oral contraceptive pill	0.2	0.3	0.7	0.9	0.7	-0.1	0.5	0.6	-0.1	-0.7	0.2	0.5	0.1	-0.1	-0.7	0.5
Diastolic blood pressure, automated reading	0.2	0.5	2.4	-1.1	-0.5	1.0	0.7	-0.6	-0.7	-1.6	-0.6	0.3	0.2	0.1	0.1	-0.4
Ever depressed for a whole week	1.7	2.1	5.4	1.9	-1.2	0.8	-0.1	-1.4	-0.5	0.4	-2.3	0.6	-2.1	-2.2	-1.6	-1.4
Unable to work because of sickness or disability	0.3	0.4	2.0	0.6	-0.6	0.8	0.8	-0.6	0.3	1.4	-0.6	0.5	0.0	-0.4	0.8	0.2
Commuting to job workplace: Cycle	0.4	0.5	1.4	-0.0	1.1	-1.2	-0.2	1.0	-0.5	-0.1	0.8	-0.5	-0.1	-0.1	0.7	0.9
Myopia	2.3	3.3	10.0	0.4	-1.9	1.1	-1.5	-2.1	-1.1	-3.2	-2.3	-1.5	-1.5	-2.2	-0.3	-2.3
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.0	0.6	-0.4	0.1	0.5	-0.2	1.3	1.4	0.0	1.4	0.7	0.9	0.6	-0.2
Cholesterol lowering medication	0.2	0.3	1.0	0.1	0.3	-0.5	-0.2	-0.1	0.3	1.0	-0.7	0.5	-0.6	-0.4	-0.8	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.9	-1.1	0.7	-0.0	1.5	0.8	1.7	-1.0	1.1	1.5	1.5	1.5	-0.7	1.4
Pain experienced in last month	0.2	0.3	1.6	1.3	0.4	-0.6	-0.5	0.6	-0.1	-0.3	0.4	0.2	-0.9	-0.2	0.3	0.2
Supplements: Calcium	0.5	0.6	1.7	0.6	1.1	-1.2	-0.7	0.9	-0.9	1.3	0.4	-0.1	-0.7	-0.5	0.2	-0.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	-0.1	-1.0	1.3	0.7	-0.8	0.9	-0.5	-0.4	1.0	1.1	-0.1	0.7	-0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.1	0.5	0.3	-0.9	-1.4	0.3	-0.7	-0.8	0.2	-0.7	-0.9	-0.5	-0.0	0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	0.5	-0.7	0.5	0.2	-0.7	-0.2	-0.0	-0.9	-0.0	-0.8	-1.0	-0.2	-0.9
Heart disease (siblings)	1.5	1.8	6.2	2.1	0.6	-1.1	-1.4	0.1	-1.7	0.5	-1.0	-0.1	-2.5	-2.1	-0.8	-0.1
Alcohol drinker status: Previous	1.6	1.8	3.8	1.8	-1.4	1.0	0.1	-1.5	1.7	1.9	-1.9	1.5	-0.3	-1.2	-0.2	-1.2
Pack years of smoking	0.4	0.6	3.1	-0.5	-0.5	0.4	-0.5	-0.4	-1.3	0.2	-0.3	-1.8	0.2	-0.2	1.4	0.1
Impedance of whole body	0.3	1.3	3.2	1.8	-0.6	-0.4	-1.6	-0.5	-1.6	-0.6	-0.9	-1.4	-1.6	-1.4	-0.6	-0.7
Leg fat mass (left)	0.4	1.6	4.0	-1.5	-1.1	2.0	1.8	-1.0	1.0	1.0	-0.4	1.5	2.0	0.8	-0.1	-0.3
Arm predicted mass (left)	0.7	3.5	7.8	-2.7	1.0	0.2	2.0	1.2	1.6	1.6	2.2	1.3	2.6	2.8	1.8	1.4