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chr4:16,885,388-18,507,692

Best TWAS P=4.8e-22 · Best GWAS P=5.33e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Artery Aorta	DCAF16	0.10	0.01	enet	6	0.02	4.7e-02	8.8	-9.7	4.8e-22	-0.71	0.03	0.88	TRUE
43	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MED28	0.08	0.05	blup	34	0.05	2.9e-03	8.3	-8.4	5.2e-17	-0.18	0.02	0.77	TRUE
48	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LAP3	0.04	0.02	blup	36	0.02	1.5e-02	8.3	8.1	5.3e-16	0.15	0.01	0.76	TRUE
16	GTEx	Nerve Tibial	DCAF16	0.16	0.14	lasso	3	0.14	2.8e-10	-6.7	-7.9	4.0e-15	-0.28	0.99	0.01	TRUE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FAM184B	0.02	0.03	lasso	2	0.02	2.6e-03	7.6	7.8	5.4e-15	0.18	0.06	0.74	TRUE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	NCAPG	0.08	0.04	blup	34	0.09	1.1e-05	8.4	7.3	2.6e-13	0.80	0.01	0.99	TRUE
31	ROSMAP	Brain Pre-frontal Cortex	DCAF16	0.04	0.02	bslmm	379	0.01	3.9e-02	8.4	-6.6	4.2e-11	-0.76	0.07	0.75	TRUE
29	ROSMAP	Brain Pre-frontal Cortex	FAM184B	0.17	0.14	enet	31	0.18	5.1e-23	8.0	9.4	4.8e-21	0.27	0.59	0.41	FALSE
9	GTEx	Breast Mammary Tissue (Male)	DCAF16	0.24	0.03	enet	18	-0.01	4.4e-01	8.4	-9.4	8.1e-21	-0.69	0.04	0.64	FALSE
24	GTEx	Thyroid	DCAF16	0.11	0.02	lasso	5	0.03	2.3e-03	-6.7	-9.2	2.4e-20	-0.47	0.17	0.70	FALSE
8	GTEx	Breast Mammary Tissue	DCAF16	0.12	0.08	lasso	4	0.10	6.4e-06	-6.7	-9.2	3.3e-20	-0.44	0.15	0.63	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCAF16	0.09	0.02	lasso	3	0.04	5.2e-05	-6.5	-9.2	3.7e-20	-0.55	0.04	0.90	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	DCAF16	0.04	0.04	blup	31	0.04	2.2e-05	-6.7	-9.1	1.0e-19	-0.50	0.26	0.25	FALSE
21	GTEx	Spleen	DCAF16	0.35	0.02	lasso	5	0.11	8.5e-04	-6.7	-8.5	1.6e-17	-0.57	0.06	0.50	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	DCAF16	0.07	0.04	blup	31	0.07	4.9e-07	-6.4	-8.5	1.8e-17	-0.56	0.22	0.66	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCAPG	0.02	0.03	lasso	1	0.02	9.0e-04	8.4	8.4	6.3e-17	0.81	0.02	0.66	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	MED28	0.03	0.03	blup	34	0.02	3.4e-03	8.5	-8.4	6.4e-17	-0.16	0.01	0.81	FALSE
15	GTEx	Muscle Skeletal	MED28	0.05	0.03	enet	8	0.02	3.1e-03	8.0	-8.3	8.9e-17	-0.16	0.39	0.31	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	MED28	0.02	0.01	blup	34	0.01	8.5e-03	8.2	-8.3	1.2e-16	-0.16	0.03	0.80	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NCAPG	0.14	0.07	lasso	3	0.07	5.2e-08	8.4	8.2	2.5e-16	0.79	0.03	0.97	FALSE
27	NTR	Blood	MED28	0.09	0.18	lasso	2	0.18	3.7e-54	8.0	-8.2	2.6e-16	-0.17	0.81	0.19	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	MED28	0.06	0.05	enet	3	0.07	1.7e-07	8.3	-8.2	2.6e-16	-0.15	0.02	0.98	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	MED28	0.02	0.01	bslmm	411	0.00	1.9e-01	8.1	-8.1	6.6e-16	-0.31	0.21	0.09	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MED28	0.03	0.02	blup	34	0.03	2.3e-04	7.6	-8.1	7.9e-16	-0.14	0.05	0.90	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	MED28	0.02	0.01	enet	4	0.01	4.0e-03	7.5	-8.0	1.2e-15	-0.12	0.02	0.84	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LAP3	0.02	0.02	lasso	4	0.01	2.2e-02	8.0	8.0	1.2e-15	0.15	0.01	0.87	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM184B	0.14	0.25	enet	21	0.24	2.0e-28	7.9	-8.0	1.3e-15	-0.15	0.93	0.07	FALSE
49	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MED28	0.10	0.12	enet	8	0.12	1.6e-05	7.9	-8.0	1.3e-15	-0.14	0.02	0.94	FALSE
13	GTEx	Esophagus Mucosa	DCAF16	0.10	0.02	lasso	4	0.02	8.3e-03	-6.7	-8.0	1.4e-15	-0.29	0.09	0.59	FALSE
11	GTEx	Cells Transformed fibroblasts	LAP3	0.20	0.12	lasso	6	0.13	3.0e-10	8.2	8.0	1.6e-15	0.14	0.89	0.11	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	DCAF16	0.16	0.08	lasso	5	0.12	4.4e-07	-6.9	-8.0	1.6e-15	-0.30	0.56	0.16	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LAP3	0.05	0.06	lasso	2	0.05	4.8e-07	7.8	7.9	3.0e-15	0.13	0.95	0.05	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	MED28	0.07	0.06	lasso	2	0.06	4.5e-07	8.0	-7.9	3.6e-15	-0.13	0.02	0.98	FALSE
23	GTEx	Testis	LAP3	0.28	0.19	lasso	3	0.19	5.1e-09	7.6	7.8	9.1e-15	0.12	0.92	0.08	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LAP3	0.04	0.08	enet	5	0.08	1.9e-09	7.6	7.7	1.2e-14	0.11	0.07	0.93	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MED28	0.07	0.09	enet	9	0.11	7.1e-13	8.0	-7.7	1.6e-14	-0.20	0.83	0.17	FALSE
54	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MED28	0.08	0.05	lasso	3	0.05	8.7e-03	7.3	-7.6	4.2e-14	-0.14	0.03	0.57	FALSE
26	NTR	Blood	LAP3	0.06	0.07	lasso	5	0.07	1.6e-22	7.6	7.5	4.3e-14	0.11	1.00	0.00	FALSE
25	GTEx	Whole Blood	LAP3	0.06	0.02	enet	7	0.02	1.1e-02	7.3	7.5	5.9e-14	0.13	0.65	0.08	FALSE
53	The Cancer Genome Atlas	Stomach Adenocarcinoma	LAP3	0.07	0.03	blup	36	0.06	5.3e-05	7.2	7.5	7.1e-14	0.16	0.02	0.98	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	LAP3	0.12	0.09	lasso	6	0.10	1.9e-12	7.6	7.5	9.6e-14	0.11	0.99	0.01	FALSE
5	GTEx	Adipose Visceral Omentum	DCAF16	0.19	0.06	enet	10	0.11	3.9e-06	-6.7	-7.4	1.2e-13	-0.28	0.43	0.20	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LAP3	0.09	0.06	lasso	2	0.05	3.3e-06	7.3	7.4	1.4e-13	0.14	0.58	0.40	FALSE
19	GTEx	Skin Sun Exposed Lower leg	DCAF16	0.14	0.12	enet	14	0.12	5.4e-10	-6.7	-7.3	2.0e-13	-0.21	1.00	0.00	FALSE
7	GTEx	Artery Tibial	DCAF16	0.16	0.16	lasso	5	0.13	1.5e-10	-6.5	-7.3	2.1e-13	-0.27	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	NCAPG	0.02	0.02	blup	34	0.02	3.4e-03	7.8	7.3	2.3e-13	0.72	0.02	0.59	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	LAP3	0.03	0.03	blup	36	0.03	2.4e-04	7.5	7.3	3.9e-13	0.13	0.09	0.80	FALSE
20	GTEx	Spleen	LAP3	0.15	0.16	lasso	3	0.15	1.3e-04	6.4	7.2	7.4e-13	0.15	0.38	0.08	FALSE
22	GTEx	Stomach	DCAF16	0.21	0.04	lasso	6	0.02	5.6e-02	-6.4	-7.0	2.4e-12	-0.16	0.19	0.05	FALSE
12	GTEx	Colon Transverse	MED28	0.13	0.05	lasso	3	0.02	5.8e-02	7.3	-7.0	3.1e-12	-0.13	0.20	0.06	FALSE
10	GTEx	Breast Mammary Tissue (Female)	DCAF16	0.16	0.13	lasso	2	0.06	7.8e-03	-6.7	-6.8	7.9e-12	-0.19	0.06	0.07	FALSE
14	GTEx	Esophagus Muscularis	DCAF16	0.16	0.14	lasso	3	0.14	9.3e-09	-6.7	-6.8	1.1e-11	-0.18	0.99	0.00	FALSE
32	YFS	Blood	DCAF16	0.02	0.02	lasso	1	0.01	1.1e-04	-6.5	-6.5	1.1e-10	-0.17	0.85	0.02	FALSE
4	GTEx	Adipose Subcutaneous	DCAF16	0.21	0.15	lasso	3	0.17	5.1e-14	-6.7	-6.4	2.0e-10	-0.16	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	NCAPG	0.06	0.02	blup	34	0.04	1.0e-05	8.4	6.0	1.7e-09	0.66	0.02	0.82	FALSE
17	GTEx	Pituitary	DCAF16	0.27	0.20	enet	15	0.19	1.3e-05	-6.7	-5.7	9.4e-09	-0.32	0.09	0.16	FALSE