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chr4:37,915,462-39,483,162

Best TWAS P=2.83e-14 · Best GWAS P=8e-14 conditioned to 0.924

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
60	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FLJ13197	0.06	0.00	blup	81	0.01	3.4e-02	-4.9	-7.6	2.8e-14	0.84	0.01	0.83	TRUE
49	ROSMAP	Brain Pre-frontal Cortex	TLR10	0.08	0.01	blup	517	0.03	3.4e-05	-2.7	6.7	2.1e-11	-0.56	0.70	0.12	TRUE
54	The Cancer Genome Atlas	Esophageal Carcinoma	FLJ13197	0.16	0.04	lasso	2	0.02	8.9e-02	-7.5	-7.5	7.5e-14	1.00	0.00	0.90	FALSE
31	GTEx	Muscle Skeletal	AC021860.1	0.16	0.10	lasso	7	0.13	1.1e-12	-7.5	-7.5	8.6e-14	0.85	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ13197	0.06	0.04	enet	9	0.06	1.3e-07	-7.5	-7.3	2.2e-13	0.83	0.00	1.00	FALSE
27	GTEx	Heart Left Ventricle	AC021860.1	0.26	0.15	lasso	5	0.19	1.4e-10	-7.5	-7.2	5.8e-13	0.90	0.00	1.00	FALSE
35	GTEx	Pancreas	RP11-617D20.1	0.34	0.27	lasso	6	0.33	1.8e-14	-7.5	-7.1	1.1e-12	0.88	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Soft Tissue Sarcoma	FLJ13197	0.08	0.02	enet	9	0.04	1.7e-03	-6.4	-7.1	1.3e-12	0.67	0.03	0.42	FALSE
12	GTEx	Brain Cerebellum	AC021860.1	0.63	0.33	lasso	16	0.43	5.7e-14	-7.5	-7.1	1.6e-12	0.83	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	FLJ13197	0.20	0.01	blup	85	0.09	1.4e-03	-4.4	-7.0	2.0e-12	0.83	0.01	0.86	FALSE
29	GTEx	Lung	AC021860.1	0.19	0.07	enet	14	0.14	8.2e-11	-7.5	-7.0	3.7e-12	0.81	0.00	1.00	FALSE
34	GTEx	Pancreas	AC021860.1	0.41	0.33	lasso	6	0.44	5.0e-20	-7.5	-7.0	3.8e-12	0.87	0.00	1.00	FALSE
26	GTEx	Heart Atrial Appendage	RP11-617D20.1	0.29	0.14	lasso	6	0.17	3.7e-08	-4.8	-6.8	1.2e-11	0.82	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ13197	0.04	0.02	blup	80	0.03	3.2e-07	-4.3	-6.8	1.3e-11	0.76	0.25	0.75	FALSE
61	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLJ13197	0.13	0.07	blup	81	0.08	2.7e-04	-7.5	-6.8	1.4e-11	0.74	0.00	0.96	FALSE
48	METSIM	Adipose	AC021860.1	0.18	0.07	bslmm	596	0.12	4.0e-17	-4.3	-6.7	1.6e-11	0.75	0.20	0.80	FALSE
10	GTEx	Brain Cerebellar Hemisphere	AC021860.1	0.50	0.30	lasso	6	0.34	1.7e-09	-7.5	-6.7	1.8e-11	0.89	0.00	1.00	FALSE
7	GTEx	Artery Aorta	RP11-617D20.1	0.27	0.18	lasso	6	0.24	1.6e-13	-4.4	-6.6	3.2e-11	0.82	0.01	0.99	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	RP11-617D20.1	0.14	0.08	enet	18	0.13	6.8e-16	-4.8	-6.6	3.7e-11	0.73	0.01	0.99	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	RP11-617D20.1	0.65	0.14	lasso	14	0.27	7.6e-08	-7.5	-6.5	6.2e-11	0.75	0.00	0.99	FALSE
13	GTEx	Brain Cerebellum	RP11-617D20.1	0.59	0.23	lasso	8	0.39	1.0e-12	-7.5	-6.5	6.8e-11	0.80	0.00	1.00	FALSE
15	GTEx	Brain Frontal Cortex BA9	RP11-617D20.1	0.34	0.14	lasso	4	0.14	1.7e-04	-7.5	-6.5	7.6e-11	0.84	0.01	0.97	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ13197	0.11	0.07	blup	85	0.10	3.4e-11	-4.4	-6.5	7.8e-11	0.71	0.09	0.91	FALSE
52	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FLJ13197	0.14	0.00	blup	81	0.04	6.7e-03	2.8	-6.5	8.1e-11	0.60	0.02	0.14	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	FLJ13197	0.16	0.08	blup	82	0.13	7.1e-13	-7.5	-6.5	9.3e-11	0.74	0.00	1.00	FALSE
45	GTEx	Vagina	RP11-617D20.1	0.31	0.01	lasso	8	0.02	1.4e-01	-4.3	-6.4	1.6e-10	0.79	0.02	0.69	FALSE
9	GTEx	Artery Tibial	RP11-617D20.1	0.32	0.23	enet	39	0.28	5.0e-22	-4.4	-6.3	2.2e-10	0.78	0.04	0.96	FALSE
24	GTEx	Esophagus Muscularis	RP11-617D20.1	0.35	0.26	lasso	6	0.31	2.5e-19	-4.3	-6.3	2.4e-10	0.77	0.04	0.96	FALSE
41	GTEx	Testis	AC021860.1	0.23	0.16	lasso	5	0.23	1.3e-10	-4.3	-6.3	3.2e-10	0.75	0.02	0.98	FALSE
47	GTEx	Whole Blood	RP11-617D20.1	0.14	0.06	lasso	3	0.05	4.2e-05	5.5	-6.2	4.0e-10	0.78	0.02	0.97	FALSE
36	GTEx	Prostate	AC021860.1	0.28	0.15	enet	29	0.28	8.1e-08	-7.5	-6.2	4.1e-10	0.66	0.00	0.98	FALSE
6	GTEx	Artery Aorta	AC021860.1	0.34	0.14	lasso	4	0.32	6.5e-18	-7.5	-6.2	4.2e-10	0.77	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	RP11-617D20.1	0.28	0.26	lasso	6	0.28	2.4e-23	-4.8	-6.2	4.9e-10	0.71	0.98	0.02	FALSE
38	GTEx	Skin Sun Exposed Lower leg	RP11-617D20.1	0.20	0.10	lasso	4	0.11	3.2e-09	-4.4	-6.2	5.6e-10	0.75	0.10	0.90	FALSE
8	GTEx	Artery Tibial	AC021860.1	0.30	0.09	enet	30	0.22	1.5e-17	-4.4	-6.2	6.3e-10	0.63	0.12	0.88	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	AC021860.1	0.23	0.11	enet	14	0.11	8.9e-05	-4.4	-6.2	6.7e-10	0.68	0.03	0.96	FALSE
32	GTEx	Nerve Tibial	AC021860.1	0.43	0.20	lasso	13	0.30	8.5e-22	3.0	-6.2	7.0e-10	0.72	0.26	0.74	FALSE
46	GTEx	Whole Blood	AC021860.1	0.14	0.07	lasso	7	0.10	2.5e-09	-4.4	-6.1	8.5e-10	0.72	0.04	0.96	FALSE
23	GTEx	Esophagus Muscularis	AC021860.1	0.40	0.19	enet	24	0.36	3.9e-23	-4.4	-6.1	8.9e-10	0.72	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLJ13197	0.08	0.04	enet	11	0.06	1.7e-07	-4.4	-6.1	8.9e-10	0.74	0.03	0.97	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-617D20.1	0.31	0.10	enet	21	0.17	3.9e-09	-4.8	-6.1	1.1e-09	0.49	0.84	0.15	FALSE
44	GTEx	Thyroid	RP11-617D20.1	0.31	0.22	enet	20	0.29	3.5e-22	-4.8	-6.1	1.1e-09	0.71	0.17	0.83	FALSE
28	GTEx	Heart Left Ventricle	RP11-617D20.1	0.28	0.14	lasso	5	0.14	6.8e-08	-4.9	-6.0	1.4e-09	0.68	0.14	0.86	FALSE
25	GTEx	Heart Atrial Appendage	AC021860.1	0.48	0.07	lasso	15	0.19	8.1e-09	-4.8	-6.0	1.5e-09	0.72	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	AC021860.1	0.32	0.28	enet	20	0.36	2.7e-30	-4.4	-6.0	1.8e-09	0.71	0.96	0.04	FALSE
64	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ13197	0.22	0.05	blup	85	0.10	2.4e-04	3.4	-6.0	1.9e-09	0.71	0.02	0.58	FALSE
21	GTEx	Colon Transverse	AC021860.1	0.32	0.10	lasso	10	0.07	2.4e-04	-4.9	-6.0	2.0e-09	0.71	0.03	0.96	FALSE
33	GTEx	Nerve Tibial	RP11-617D20.1	0.35	0.10	enet	81	0.20	7.0e-14	-4.3	-5.9	3.0e-09	0.53	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ13197	0.11	0.07	blup	85	0.08	7.0e-10	-4.4	-5.9	3.3e-09	0.62	0.16	0.84	FALSE
3	GTEx	Adipose Visceral Omentum	AC021860.1	0.33	0.08	lasso	9	0.13	3.2e-07	-4.4	-5.8	7.2e-09	0.57	0.18	0.78	FALSE
20	GTEx	Colon Sigmoid	RP11-617D20.1	0.45	0.34	lasso	8	0.34	9.5e-13	-4.8	-5.8	8.9e-09	0.65	0.33	0.66	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ13197	0.12	0.00	blup	85	0.05	9.1e-04	-4.4	-5.7	9.5e-09	0.51	0.08	0.45	FALSE
30	GTEx	Lung	RP11-617D20.1	0.19	0.14	enet	9	0.14	1.3e-10	-4.4	-5.7	9.9e-09	0.67	0.30	0.70	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLJ13197	0.20	0.10	blup	81	0.14	4.2e-14	-4.8	-5.7	1.0e-08	0.62	0.65	0.35	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	AC021860.1	0.37	0.05	enet	20	0.12	5.2e-04	3.0	-5.7	1.2e-08	0.63	0.02	0.93	FALSE
42	GTEx	Testis	RP11-617D20.1	0.28	0.16	lasso	5	0.18	1.9e-08	-4.3	-5.7	1.5e-08	0.76	0.01	0.99	FALSE
39	GTEx	Stomach	AC021860.1	0.37	0.14	enet	27	0.18	5.9e-09	-4.8	-5.6	2.1e-08	0.56	0.26	0.72	FALSE
18	GTEx	Brain Putamen basal ganglia	RP11-617D20.1	0.44	0.12	lasso	7	0.26	8.3e-07	-7.5	-5.6	2.3e-08	0.77	0.00	0.99	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	AC021860.1	0.43	0.32	lasso	8	0.35	4.0e-20	-4.4	-5.5	3.7e-08	0.69	0.59	0.41	FALSE
40	GTEx	Stomach	RP11-617D20.1	0.32	0.23	enet	13	0.20	6.5e-10	-4.8	-5.5	4.0e-08	0.58	0.70	0.30	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ13197	0.08	0.05	blup	85	0.03	6.4e-03	-4.3	-5.4	5.9e-08	0.58	0.09	0.75	FALSE
19	GTEx	Breast Mammary Tissue	AC021860.1	0.49	0.13	enet	29	0.27	2.2e-14	-4.4	-5.4	8.2e-08	0.55	0.68	0.31	FALSE
5	GTEx	Adrenal Gland	AC021860.1	0.30	0.11	lasso	5	0.12	4.1e-05	-4.9	-5.2	1.8e-07	0.53	0.08	0.73	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RP11-617D20.1	0.53	0.25	lasso	8	0.32	5.1e-09	-7.5	-5.2	2.3e-07	0.83	0.00	0.99	FALSE
14	GTEx	Brain Cortex	AC021860.1	0.42	0.32	lasso	3	0.38	1.3e-11	3.0	-5.2	2.3e-07	0.65	0.09	0.91	FALSE
43	GTEx	Thyroid	AC021860.1	0.30	0.22	lasso	4	0.30	5.4e-23	3.0	-5.2	2.5e-07	0.58	0.99	0.01	FALSE