Best TWAS P=9.96e-30 · Best GWAS P=8.99e-46 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | REST | 0.04 | 0.01 | lasso | 5 | 0.02 | 7.8e-04 | 5.3 | 11.3 | 1.0e-29 | -0.70 | 0.05 | 0.75 | TRUE |
| 2 | GTEx | Colon Transverse | REST | 0.26 | 0.04 | lasso | 9 | 0.10 | 1.9e-05 | 4.5 | 10.4 | 4.0e-25 | -0.65 | 0.03 | 0.93 | TRUE |
| 4 | METSIM | Adipose | RP11-738E22.3 | 0.07 | 0.04 | lasso | 6 | 0.05 | 7.7e-08 | 5.3 | -8.0 | 1.3e-15 | 0.46 | 0.85 | 0.15 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | POLR2B | 0.04 | 0.00 | blup | 116 | 0.01 | 5.2e-02 | 1.6 | 8.0 | 1.7e-15 | -0.53 | 0.04 | 0.23 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | REST | 0.04 | 0.02 | bslmm | 536 | 0.02 | 3.4e-03 | 7.3 | 6.7 | 2.3e-11 | -0.39 | 0.22 | 0.48 | TRUE |
| 1 | GTEx | Artery Aorta | NOA1 | 0.17 | 0.06 | lasso | 4 | 0.06 | 3.5e-04 | -9.3 | 8.6 | 7.8e-18 | -0.46 | 0.36 | 0.23 | FALSE |
| 3 | GTEx | Muscle Skeletal | REST | 0.05 | 0.01 | enet | 9 | 0.02 | 3.9e-03 | 4.6 | 8.2 | 2.4e-16 | -0.43 | 0.28 | 0.59 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf14 | 0.03 | 0.04 | lasso | 3 | 0.04 | 1.9e-05 | 8.7 | 8.0 | 1.6e-15 | -0.37 | 0.23 | 0.21 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C4orf14 | 0.13 | 0.11 | lasso | 2 | 0.10 | 6.2e-05 | 6.6 | 5.5 | 4.8e-08 | -0.22 | 0.12 | 0.04 | FALSE |