Best TWAS P=1.41e-34 · Best GWAS P=7.14e-40 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PCDHGA2 | 0.04 | 0.03 | enet | 3 | 0.04 | 1.0e-05 | 4.717 | -5.2 | 2.0e-07 | 0.05 | 0.14 | 0.85 | FALSE |
2 | GTEx | Esophagus Muscularis | PCDHGA2 | 0.11 | 0.08 | lasso | 3 | 0.07 | 4.4e-05 | 5.085 | -5.1 | 3.1e-07 | 0.07 | 0.08 | 0.90 | FALSE |
3 | GTEx | Muscle Skeletal | NDFIP1 | 0.20 | 0.10 | lasso | 9 | 0.12 | 3.8e-12 | -13.183 | 12.3 | 1.4e-34 | -0.93 | 0.01 | 0.99 | TRUE |
4 | GTEx | Skin Not Sun Exposed Suprapubic | GNPDA1 | 0.18 | 0.02 | lasso | 8 | 0.01 | 6.2e-02 | -7.433 | 7.1 | 1.6e-12 | -0.56 | 0.04 | 0.66 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | GNPDA1 | 0.11 | 0.00 | enet | 23 | 0.00 | 1.5e-01 | 7.025 | 5.8 | 7.8e-09 | -0.69 | 0.02 | 0.92 | TRUE |
6 | METSIM | Adipose | GNPDA1 | 0.10 | 0.03 | lasso | 6 | 0.04 | 3.5e-06 | 2.583 | 5.6 | 1.7e-08 | -0.35 | 0.86 | 0.02 | TRUE |
7 | METSIM | Adipose | NDFIP1 | 0.23 | 0.15 | lasso | 8 | 0.16 | 7.1e-23 | -10.754 | -10.0 | 2.2e-23 | 0.73 | 1.00 | 0.00 | TRUE |
8 | NTR | Blood | NDFIP1 | 0.03 | 0.00 | blup | 610 | 0.01 | 2.9e-03 | -8.111 | -5.6 | 1.8e-08 | 0.63 | 0.02 | 0.96 | FALSE |
9 | YFS | Blood | GNPDA1 | 0.06 | 0.03 | blup | 538 | 0.04 | 1.2e-13 | -0.021 | 7.7 | 1.5e-14 | -0.32 | 1.00 | 0.00 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NDFIP1 | 0.04 | 0.01 | lasso | 3 | 0.01 | 1.2e-03 | -2.530 | 5.4 | 5.2e-08 | -0.65 | 0.09 | 0.24 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | PCDHGA10 | 0.06 | 0.00 | blup | 93 | 0.01 | 6.7e-03 | 1.492 | 5.8 | 6.6e-09 | -0.08 | 0.01 | 0.19 | TRUE |
12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PCDHGA8 | 0.05 | 0.01 | blup | 101 | 0.02 | 2.6e-03 | -5.792 | 5.3 | 9.4e-08 | -0.01 | 0.00 | 0.91 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | GNPDA1 | 0.11 | 0.00 | blup | 67 | 0.03 | 1.5e-03 | -3.716 | -5.5 | 4.2e-08 | 0.19 | 0.01 | 0.07 | TRUE |