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chr11:60,846,825-63,284,510

Best TWAS P=3.03e-24 · Best GWAS P=2.3e-34 conditioned to 8.96e-28

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	EML3	0.07	0.00	enet	22	0.02	6.0e-03	0.16	-6.9	4.6e-12	-0.24	0.11	0.10	TRUE
2	GTEx	Artery Aorta	FADS2	0.18	0.17	lasso	3	0.14	3.2e-08	10.06	9.6	6.5e-22	-0.01	0.00	1.00	FALSE
3	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	5.40	6.0	2.6e-09	0.00	0.13	0.73	FALSE
4	GTEx	Cells Transformed fibroblasts	FADS2	0.20	0.23	lasso	3	0.23	4.6e-17	10.06	10.1	5.3e-24	-0.01	0.00	1.00	FALSE
5	GTEx	Colon Sigmoid	FADS2	0.24	0.12	lasso	5	0.13	2.2e-05	6.30	6.4	1.7e-10	0.00	0.02	0.94	FALSE
6	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	10.06	8.5	2.1e-17	-0.04	0.00	1.00	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	FADS2	0.22	0.22	lasso	2	0.20	7.8e-08	10.06	10.0	1.6e-23	-0.01	0.00	1.00	FALSE
8	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	10.06	9.7	3.1e-22	0.00	0.00	1.00	FALSE
9	GTEx	Heart Atrial Appendage	FADS2	0.16	0.11	lasso	1	0.04	5.1e-03	10.06	10.1	8.1e-24	-0.01	0.00	1.00	FALSE
10	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	7.81	8.9	6.0e-19	-0.02	0.01	0.99	FALSE
11	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	4.41	6.3	2.3e-10	0.01	0.22	0.76	FALSE
12	GTEx	Nerve Tibial	FADS2	0.20	0.14	lasso	3	0.13	1.5e-09	10.06	10.2	3.0e-24	-0.01	0.00	1.00	TRUE
13	GTEx	Nerve Tibial	RP11-727F15.9	0.13	0.00	enet	28	0.06	9.1e-05	-0.81	-5.1	3.1e-07	-0.17	0.12	0.11	FALSE
14	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	10.06	9.6	1.0e-21	0.00	0.00	1.00	FALSE
15	GTEx	Thyroid	FADS2	0.16	0.18	lasso	4	0.17	7.0e-13	10.06	10.0	1.9e-23	-0.01	0.00	1.00	FALSE
16	GTEx	Whole Blood	FADS2	0.49	0.48	lasso	5	0.48	3.0e-49	10.06	10.0	1.5e-23	0.00	0.00	1.00	FALSE
17	METSIM	Adipose	FADS2	0.07	0.05	lasso	3	0.04	3.2e-07	10.06	10.1	5.6e-24	-0.01	0.00	1.00	FALSE
18	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	5.40	5.4	5.3e-08	0.00	1.00	0.00	FALSE
19	NTR	Blood	FADS2	0.30	0.33	lasso	7	0.33	9.0e-109	10.06	9.9	3.5e-23	0.00	0.00	1.00	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	5.40	5.2	1.9e-07	0.02	1.00	0.00	FALSE
21	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	10.06	8.9	7.1e-19	0.00	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS2	0.05	0.04	lasso	2	0.04	2.2e-09	10.06	9.4	3.3e-21	0.00	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	10.06	9.3	1.2e-20	0.00	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FADS2	0.05	0.04	lasso	3	0.05	1.9e-06	10.06	9.1	6.0e-20	0.01	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	10.06	9.1	1.2e-19	-0.01	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	10.06	9.1	1.0e-19	0.02	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	4.94	-5.5	2.9e-08	0.02	0.75	0.16	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	FADS2	0.04	0.04	lasso	4	0.02	1.7e-03	10.06	9.9	3.3e-23	0.00	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FADS2	0.15	0.16	lasso	2	0.12	8.8e-06	10.06	9.4	3.8e-21	-0.01	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf10	0.02	0.01	enet	11	0.01	1.6e-02	5.40	5.5	3.1e-08	0.02	0.03	0.46	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS2	0.07	0.07	lasso	4	0.06	1.9e-06	10.06	9.1	8.6e-20	0.01	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	10.06	9.7	4.4e-22	0.01	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	10.06	6.4	1.3e-10	0.00	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	10.06	9.5	2.8e-21	0.00	0.00	1.00	FALSE