Best TWAS P=5.17e-10 · Best GWAS P=1.68e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C2orf82 | 0.14 | 0.22 | lasso | 6 | 0.23 | 3.8e-27 | -5.9 | 5.9 | 3.6e-09 | -1.00 | 0.01 | 0.99 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | C2orf82 | 0.27 | 0.26 | lasso | 1 | 0.24 | 1.2e-07 | -6.0 | 6.0 | 1.7e-09 | -1.00 | 0.01 | 0.99 | FALSE |
3 | GTEx | Brain Cerebellum | C2orf82 | 0.15 | 0.18 | lasso | 2 | 0.13 | 1.1e-04 | -6.0 | 6.0 | 2.2e-09 | -1.00 | 0.01 | 0.97 | FALSE |
4 | GTEx | Brain Cortex | C2orf82 | 0.17 | 0.18 | lasso | 1 | 0.08 | 2.8e-03 | -6.0 | 6.0 | 1.7e-09 | -1.00 | 0.02 | 0.95 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | C2orf82 | 0.24 | 0.16 | lasso | 10 | 0.12 | 3.9e-04 | -5.9 | 6.2 | 5.2e-10 | -0.97 | 0.02 | 0.97 | TRUE |
6 | GTEx | Brain Nucleus accumbens basal ganglia | C2orf82 | 0.19 | 0.18 | lasso | 5 | 0.14 | 1.1e-04 | -6.0 | 5.8 | 9.0e-09 | -0.96 | 0.01 | 0.97 | FALSE |
7 | GTEx | Brain Putamen basal ganglia | C2orf82 | 0.28 | 0.22 | lasso | 3 | 0.18 | 5.3e-05 | -6.0 | 6.2 | 6.1e-10 | -0.98 | 0.02 | 0.91 | FALSE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | C2orf82 | 0.19 | 0.19 | lasso | 5 | 0.20 | 5.5e-11 | -6.0 | 5.9 | 3.9e-09 | -0.99 | 0.00 | 1.00 | FALSE |
9 | GTEx | Skin Sun Exposed Lower leg | C2orf82 | 0.16 | 0.14 | lasso | 4 | 0.15 | 1.3e-12 | -6.0 | 6.0 | 1.5e-09 | -0.98 | 0.00 | 1.00 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | C2orf82 | 0.31 | 0.50 | enet | 24 | 0.50 | 1.3e-73 | -5.9 | 6.1 | 8.2e-10 | -0.99 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Glioblastoma Multiforme | C2orf82 | 0.20 | 0.24 | lasso | 8 | 0.20 | 9.1e-07 | -5.9 | 5.9 | 3.3e-09 | -0.99 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EFHD1 | 0.11 | 0.01 | blup | 70 | 0.03 | 1.0e-02 | 2.0 | 5.2 | 2.7e-07 | -0.39 | 0.01 | 0.53 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C2orf82 | 0.14 | 0.20 | enet | 6 | 0.19 | 3.1e-21 | -5.9 | 5.9 | 3.1e-09 | -0.98 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NGEF | 0.03 | 0.01 | blup | 130 | 0.01 | 2.0e-02 | -5.2 | 5.4 | 5.3e-08 | -0.91 | 0.01 | 0.92 | FALSE |
15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | KCNJ13 | 0.07 | 0.07 | blup | 36 | 0.06 | 2.4e-03 | -5.2 | 5.5 | 3.8e-08 | -0.78 | 0.01 | 0.87 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GIGYF2 | 0.04 | 0.00 | blup | 103 | 0.02 | 2.1e-03 | -5.9 | -6.2 | 5.8e-10 | 0.83 | 0.02 | 0.90 | FALSE |