Hub : Genes

EPHA4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0720 0.0290 7.3e-03 0.012 -0.002 -0.002 0.001 0.001 1.0e-02 6.2e-01 7.8e-01 2.1e-01 2.0e-01
2 GTEx Testis 0.4450 0.0830 7.7e-07 0.043 NA 0.122 NA 0.049 5.3e-03 NA 4.7e-06 NA 3.1e-03
3 GTEx Thyroid 0.1000 0.0420 9.2e-03 0.015 NA 0.022 NA 0.007 2.3e-02 NA 7.4e-03 NA 8.5e-02
4 METSIM Adipose 0.0401 0.0167 2.7e-03 0.010 0.023 0.010 0.022 0.007 1.1e-02 1.6e-04 9.8e-03 2.1e-04 3.0e-02
5 NTR Blood 0.0635 0.0147 2.4e-11 0.057 0.040 0.051 0.049 0.053 1.0e-17 5.1e-13 4.9e-16 1.5e-15 1.3e-16
6 ROSMAP Brain Pre-frontal Cortex 0.0443 0.0211 1.3e-02 0.029 0.005 -0.002 0.004 0.004 1.2e-04 6.5e-02 7.9e-01 8.6e-02 7.7e-02
7 YFS Blood 0.0893 0.0172 0.0e+00 0.099 0.077 0.105 0.105 0.106 1.1e-30 4.6e-24 1.5e-32 1.8e-32 1.2e-32
8 TCGA Testicular Germ Cell Tumors 0.2520 0.1110 8.6e-03 0.126 0.026 0.106 NA 0.072 3.4e-05 4.1e-02 1.4e-04 NA 1.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.4 0.6 1.2 0.4 0.1 1.0 -1.1 -1.0 -0.5 -0.8 -0.7
Bipolar Disorder or Schizophrenia 0.9 2.3 7.1 1.3 -0.6 -0.5 -0.5 -2.5 -0.2 -2.7 -1.5
Depressed Affect (Nagel 2018) 0.6 1.2 4.9 1.0 -2.2 -1.2 0.5 -0.5 0.0 -0.9 0.8
Depression (Nagel 2018) 0.4 0.6 2.5 0.2 -1.6 -0.9 0.4 0.2 -0.3 -0.0 -1.1
Intelligence (Savage-Jansen 2018) 0.4 1.1 2.4 0.4 1.0 1.3 -1.4 -0.8 -0.9 -0.6 -1.5
Neuroticism (Nagel 2018) 1.0 2.4 7.5 0.6 -1.9 -0.2 -0.5 -2.5 -0.4 -2.7 -0.9
Schizophrenia (2018) 1.3 2.6 7.4 1.5 -1.1 -1.5 0.3 -2.5 0.2 -2.7 -1.3
Schizophrenia vs Biploar Disorder 1.1 1.5 2.9 1.3 -0.8 -1.7 1.7 -1.0 1.0 -1.3 -0.0
Worry (Nagel 2018) 1.2 2.5 7.0 1.0 -1.3 0.7 -0.1 -2.6 0.7 -2.6 -1.4
Alzheimer’s Disease (in mother) 1.0 1.1 5.1 -2.3 1.6 0.5 -0.6 -0.7 -0.3 -0.2 0.5
Alzheimer’s Disease (in father) 1.0 1.1 3.0 1.4 0.0 -0.9 -1.0 0.9 -1.7 0.6 -0.9
Alzheimer’s Disease (including proxy) 0.6 0.9 3.5 -0.9 1.2 -0.2 -0.8 -0.5 -1.9 -0.4 0.6
Crohns Disease (2017) 0.8 1.8 5.5 2.3 1.5 -1.7 -0.8 -1.4 0.5 -1.0 -0.1
Irritable Bowel Disease (IBD) 0.3 0.7 2.8 1.7 -0.4 -0.8 -0.4 -0.2 1.2 0.1 -0.4
Ulcerative Colitis (UC) 0.4 0.8 3.1 0.4 -1.8 0.3 0.2 0.7 1.3 1.0 -0.3
Major Depression (MDD) 1.0 1.2 3.8 1.9 -1.7 -0.3 0.0 -0.3 -0.4 -0.4 1.7
Reaction Time 1.8 3.4 8.4 1.3 -2.9 -0.6 1.8 2.9 -0.5 2.1 0.6
Verbal and Numeric Reasoning (VNR) 0.6 1.5 3.5 0.6 1.1 1.9 -0.9 -1.5 -0.2 -1.4 -1.4
Breast Cancer 0.4 1.0 3.5 -1.9 1.4 -0.4 1.0 -0.0 0.8 0.2 0.7
Ovarian Cancer 0.3 0.4 1.8 0.8 -0.2 1.3 -0.3 0.1 0.7 0.3 -0.5
Prostate Cancer 1.3 1.8 5.3 -1.2 2.3 -1.5 -1.1 -0.2 -0.8 0.1 -1.8
Age at First Birth 0.8 1.1 4.1 1.1 0.2 -0.4 -0.5 -0.9 1.0 -1.1 -2.0
Bipolar Disorder (2011) 1.4 1.3 3.3 0.7 -1.4 -1.1 -1.4 0.9 -0.6 0.9 1.8
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 0.6 -0.4 -0.6 0.0 -0.6 0.6 -1.0 -0.6
Coronary Artery Disease (CAD) 1.1 1.3 4.5 -0.5 -0.8 0.6 2.1 1.4 1.0 1.2 0.5
Crohns Disease (2012) 0.7 1.1 3.9 1.3 0.0 -2.0 -0.7 -0.4 1.0 -0.2 -1.1
Mean Putamen Volume 0.2 0.2 1.3 -0.5 -0.0 -1.1 -0.3 0.1 0.1 0.1 0.3
Fasting Glucose 1.5 1.7 5.4 -0.3 2.3 1.5 -0.3 -0.9 -2.0 -0.7 0.9
HbA1C 0.5 0.5 1.7 0.1 -0.3 0.2 -1.3 -0.4 -1.2 -0.5 -0.7
HDL Cholesterol 1.4 2.3 6.5 -0.3 1.4 -0.3 -2.4 -1.0 -2.5 -0.6 1.8
LDL Cholesterol 0.5 0.8 1.9 1.0 -0.9 0.5 0.6 -1.2 0.6 -1.4 0.7
Lupus 1.1 1.6 4.3 1.1 0.8 0.7 -0.2 -2.1 -0.3 -1.9 1.5
Neuroticism (2016) 0.3 0.4 1.8 -0.6 -0.6 0.2 -0.3 -0.2 -1.3 -0.4 0.1
Primary Biliary Cirrhosis 0.2 0.3 1.3 0.2 -0.4 1.1 -0.1 0.1 -0.7 0.0 0.4
Rheumatoid Arthritis 1.1 1.5 4.1 0.9 -1.0 0.5 1.6 1.0 2.0 1.3 -1.1
Schizophrenia (2014) 1.0 2.2 4.5 1.9 -1.5 -1.4 0.6 -1.9 0.3 -2.1 -1.1
Triglycerides 0.3 0.5 2.2 -0.6 -0.3 -0.7 0.4 0.2 0.4 0.3 -1.5
Type 2 Diabetes (T2D) (2012) 1.1 1.3 3.2 -0.3 -1.8 0.9 1.2 1.4 0.4 0.9 -1.3
Ulcerative Colitis 1.1 1.6 4.7 0.3 -1.8 0.6 0.7 1.7 0.9 2.2 -0.3
Blood Eosinophil Count 0.1 0.6 2.5 0.6 1.6 -0.2 0.2 -0.5 1.1 -0.4 0.0
Blood Platelet Count 0.3 3.4 13.0 1.2 1.6 -0.4 -3.6 0.7 -2.2 1.5 1.4
Blood Red Count 0.2 2.1 8.0 0.1 -2.8 -0.5 0.1 0.2 2.8 0.2 -0.7
Blood White Count 0.2 1.2 3.9 2.0 0.3 -0.6 -0.1 0.7 1.8 1.2 -0.0
Heel T-Score 0.4 2.8 10.0 -0.1 -0.7 -1.4 0.7 -2.7 0.5 -3.2 -1.6
BMI 0.3 1.7 4.7 0.4 -1.6 -0.6 -1.1 -1.2 2.2 -1.1 -1.2
Height 0.2 4.0 9.0 -1.7 -0.6 2.4 2.6 -1.6 0.7 -1.9 -3.0
Waist Hip Ratio (WHR) 0.6 2.5 4.7 -0.8 -0.4 -2.1 2.2 2.0 0.1 1.4 2.1
Systolic Blood Pressure 0.2 1.1 4.0 -1.7 -0.3 2.0 0.9 -0.6 0.5 -0.3 0.2
Smoking Status 0.4 0.9 2.7 0.3 -0.6 -0.4 1.7 -0.9 0.4 -1.2 -1.0
Allergy or Eczema 0.4 1.0 4.9 1.4 0.6 -2.2 -0.4 0.4 -0.5 0.4 0.2
Cardiovascular Disease 0.8 2.8 9.5 -0.2 0.7 0.5 -1.7 -3.1 -0.7 -2.7 -1.2
Hypothyroidism (self reported) 0.5 1.2 5.2 0.5 -0.8 1.0 2.3 1.1 0.1 1.1 0.5
Respiratory disease 1.0 2.3 6.2 2.5 -1.6 -2.3 -1.1 0.4 -0.1 0.3 -1.6
Type 2 Diabetes (T2D) (2018) 0.7 1.3 5.3 -0.7 1.4 2.3 -0.3 0.3 -0.0 0.5 -1.4
Lung FEV1/FVC ratio 0.2 0.9 3.4 -0.5 -0.2 0.5 -0.9 1.2 -0.1 1.1 -1.9
Lung FVC 0.2 1.2 2.6 1.5 -0.8 -0.8 -1.1 -0.9 -1.6 -1.3 0.4
Neuroticism 0.8 2.0 5.9 1.1 -1.5 -0.8 -0.5 -2.3 0.1 -2.4 -0.4
Chronotype (morning person) 0.7 1.7 5.1 -0.8 1.0 -0.6 -0.8 -2.2 -0.8 -2.1 0.9
Hair Pigment 6.5 186.1 441.0 0.1 -14.0 19.4 21.0 11.7 15.0 9.1 5.7
Tanning 0.2 2.1 6.1 0.1 1.8 -2.5 -1.4 0.2 -2.5 0.2 0.2
Hand grip strength (left) 0.4 0.9 2.1 0.2 0.3 -0.5 -1.2 -1.3 -1.0 -1.4 -0.8
Number of treatments/medications taken 0.4 0.7 2.5 -0.0 -1.1 -0.2 -1.3 -0.2 -1.6 -0.1 0.0
Average weekly spirits intake 1.4 1.8 4.1 0.1 1.9 -0.3 -2.0 -0.2 -1.8 -0.2 -1.8
Sensitivity / hurt feelings 1.7 2.9 6.0 -0.7 1.6 -0.8 -2.0 -2.4 -2.2 -2.1 0.2
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.5 -1.5 -0.8 -1.6 0.3 0.3 -1.1 -0.1 1.0
Hearing difficulty/problems: Yes 0.4 0.6 1.8 -0.4 0.1 0.4 0.1 1.1 -0.1 1.4 1.3
Relative age of first facial hair 1.6 3.2 7.1 -1.5 0.2 1.3 2.0 -1.5 2.5 -1.5 -2.7
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 6.1 1.1 -1.1 -0.1 1.7 2.5 1.1 2.2 -0.1
Ever used hormone-replacement therapy (HRT) 1.1 1.5 2.6 1.4 1.6 -0.5 -1.4 -1.0 -1.3 -0.6 -1.4
Ever had hysterectomy (womb removed) 0.6 0.7 1.6 1.2 0.5 -1.3 -0.5 -0.9 -0.9 -0.7 0.3
Systolic blood pressure, automated reading 0.1 0.3 1.6 -1.3 -0.5 0.0 0.4 0.0 -0.1 0.3 -0.8
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.5 0.5 0.3 -0.6 1.2 0.5 1.2 0.3 -0.4
Angina 0.4 0.5 1.2 -0.9 1.1 -0.3 0.8 0.3 1.1 0.5 0.4
Medication for hormone replacement therapy 2.8 3.2 6.0 1.6 0.3 -1.3 -2.1 -2.3 -2.4 -2.2 -0.6
Vitamin and mineral supplements 1.6 2.1 5.4 -0.5 -1.5 -0.1 1.4 1.9 2.3 1.8 0.3
Supplements: Zinc 0.5 0.5 1.4 0.9 -0.5 1.2 1.2 0.2 -0.3 0.2 -0.3
Medication: Co-codamol 1.3 1.5 6.7 1.4 -0.9 -2.6 1.5 -0.4 0.0 -0.4 0.1
Medication: Metformin 0.5 0.7 2.5 0.5 1.6 0.7 -1.0 -0.4 -0.5 -0.1 -0.7
Diabetes (father) 1.9 2.3 7.0 -0.9 -1.4 0.2 2.6 1.2 2.0 1.4 1.0
Diabetes (mother) 0.2 0.2 0.5 0.7 -0.2 -0.2 0.7 0.5 0.5 0.2 0.4
Severe depression (siblings) 1.1 1.3 4.5 2.1 -0.7 -1.1 -0.3 -0.1 -1.0 -0.3 1.7
Pack years adult smoking proportion 0.2 0.3 0.5 -0.3 -0.7 0.4 -0.5 0.7 -0.1 0.7 -0.4
Impedance of leg (right) 0.2 0.8 4.5 0.3 2.1 0.6 -0.1 -0.7 -0.5 -0.4 -0.9
Leg fat-free mass (left) 0.3 1.6 5.6 -0.6 -2.4 0.6 1.1 -0.4 1.7 -0.8 -1.3
Trunk fat percentage 0.4 1.4 3.2 -0.1 -1.6 -0.2 -0.1 -1.5 0.3 -1.7 -1.8
Hand grip strength (right) 0.4 1.1 4.4 0.5 0.9 -0.2 -2.1 -1.1 -0.4 -1.2 -0.7
Townsend deprivation index at recruitment 0.9 1.3 2.3 0.7 -1.3 -0.9 1.3 1.5 1.1 1.4 0.3
Current tobacco smoking 0.5 0.8 2.6 0.3 -1.6 -1.2 0.7 1.0 0.9 0.5 0.0
Average weekly fortified wine intake 0.2 0.3 0.9 0.2 -1.0 -0.3 -0.7 -0.3 -0.4 -0.3 0.7
Maternal smoking around birth 1.0 1.5 7.1 0.8 1.0 -1.2 2.7 -0.0 0.5 -0.2 1.2
Fed-up feelings 0.5 0.9 1.9 1.4 -1.1 -0.3 0.0 -0.7 -0.5 -1.1 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 4.3 -0.3 0.5 -2.1 -0.5 -0.2 -1.4 -0.3 0.1
Relative age voice broke 1.4 2.1 4.7 -1.4 1.0 1.3 2.2 -1.3 1.6 -1.1 -1.4
Taking other prescription medications 0.5 0.8 2.5 0.9 -0.8 -0.1 -0.4 0.6 -1.6 0.9 1.0
Age when periods started (menarche) 0.5 1.2 4.2 -1.4 -0.4 -0.4 2.1 -0.2 1.7 -0.2 0.4
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 3.7 1.2 1.0 -0.8 -1.9 -1.3 -0.8 -0.9 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 11.7 0.6 -1.6 -1.1 1.2 -2.6 0.3 -3.4 0.7
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 -0.5 -0.6 -0.0 -0.5 0.3 -0.4 0.0 -0.1
Qualifications: CSEs or equivalent 0.5 0.7 2.1 0.3 0.3 -1.4 -1.4 -0.5 -0.5 -0.3 0.8
Serious illness, injury or assault to yourself 0.3 0.3 0.9 0.7 -0.5 0.9 0.9 0.1 0.4 -0.2 -0.1
High blood pressure 0.5 1.4 4.0 -2.0 0.2 0.7 -0.4 -2.0 -0.6 -1.4 -0.7
Hayfever, allergic rhinitis or eczema 0.8 1.7 5.0 1.0 0.3 -2.2 -0.3 1.7 -1.1 1.6 0.9
Multivitamins +/- minerals 1.5 1.9 5.2 0.6 0.4 -0.1 -1.6 -2.3 -1.4 -2.2 -0.1
Stomach or abdominal pain in last month 0.4 0.5 1.2 0.1 -0.7 0.9 -1.0 0.4 -0.2 0.5 1.1
Supplements: Glucosamine 0.5 0.7 3.0 -0.2 -1.7 -0.6 0.6 -0.0 -0.7 -0.4 -1.0
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 2.2 1.1 0.1 0.6 0.4 -0.3 0.1 -0.6 1.5
Medication: Atenolol 0.4 0.5 0.9 -0.3 -0.8 -0.9 0.1 0.7 0.8 0.9 -0.2
Medication: Levothyroxine sodium 0.5 0.9 1.6 1.1 -0.9 1.0 1.2 1.0 0.2 1.1 0.0
Sitting height 0.6 4.2 11.8 -2.0 0.0 3.4 2.5 -1.2 0.7 -1.6 -2.7
Chronic bronchitis/emphysema (father) 1.1 1.3 2.4 1.3 -1.6 -1.4 -1.1 -0.7 -1.2 -0.7 0.8
High blood pressure (mother) 0.6 0.9 3.6 -0.7 0.1 1.9 -1.2 -0.6 0.0 -0.6 -1.0
Body mass index (BMI) 0.3 1.3 4.8 0.6 -2.2 -0.8 -0.6 -0.6 1.3 -0.9 -1.2
Impedance of leg (left) 0.3 1.4 5.8 0.3 2.4 0.6 -0.4 -1.2 -1.2 -1.1 -0.6
Leg predicted mass (left) 0.3 1.6 5.5 -0.6 -2.3 0.6 1.1 -0.4 1.7 -0.8 -1.3
Trunk fat mass 0.4 1.6 4.2 -0.3 -1.8 0.2 0.0 -1.5 0.6 -1.7 -2.0
Waist circumference 0.2 0.7 2.3 0.1 -1.1 -0.6 0.1 -0.3 1.5 -0.6 -1.1
Number of incorrect matches in round 0.6 1.0 2.9 -1.7 1.4 -0.8 0.5 0.5 0.1 0.5 1.3
Past tobacco smoking 0.9 1.7 7.5 0.2 -0.2 -0.6 -1.0 1.2 -0.7 1.7 2.7
Alcohol usually taken with meals 0.2 0.3 0.7 0.7 0.9 0.9 -0.1 0.3 -0.6 0.1 -0.2
Nervous feelings 1.0 1.8 4.3 0.2 -1.0 0.5 0.6 -1.7 2.1 -1.8 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 3.7 -0.1 -0.4 -1.9 -0.7 -0.9 -1.5 -0.9 -0.1
Hearing difficulty/problems with background noise 0.5 0.8 1.8 0.7 -1.3 -1.4 0.1 1.1 0.0 1.0 0.5
Hair/balding pattern: Pattern 2 2.8 3.5 8.9 2.5 -0.6 -1.6 -0.0 -2.7 -0.8 -3.0 -1.6
Had menopause 0.8 1.0 5.8 1.2 0.0 -0.2 0.2 -0.1 0.6 0.2 -2.4
Had other major operations 0.7 0.9 2.1 -0.3 -0.1 -1.1 1.4 -1.1 -0.3 -1.4 0.7
Forced vital capacity (FVC) 0.1 0.2 0.9 0.4 0.1 0.2 -0.1 -0.8 0.1 -0.9 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.4 12.0 1.4 -0.9 -1.7 0.0 -3.0 0.3 -3.5 0.6
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 4.4 -0.5 -1.0 -1.3 0.8 -1.6 -0.3 -2.1 1.4
Qualifications: None of the above 1.6 3.4 9.5 -0.1 -0.1 -1.3 2.2 3.1 1.5 2.9 -0.5
Financial difficulties in last 2 years 0.1 0.1 0.4 -0.4 -0.6 0.1 0.3 0.3 -0.2 -0.1 -0.0
Mouth/teeth dental problems 1.2 1.8 4.6 -0.5 1.6 -1.2 -2.1 1.5 -0.6 1.6 -0.1
Heart attack 0.6 0.8 3.0 1.7 -0.2 0.1 -0.9 -0.7 -1.3 -0.3 0.6
Allergy 0.6 1.3 2.7 -1.6 0.1 1.4 0.7 -1.3 1.5 -1.3 -0.5
Pain all over the body in last month 1.2 1.2 7.4 -0.1 -0.5 0.3 1.1 0.5 2.7 0.5 -0.7
Diabetes (self-reported) 0.6 0.9 2.8 -1.5 1.7 1.1 -0.3 0.4 0.6 0.7 -0.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.6 -0.7 -1.3 0.5 -0.1 -0.7 -0.1 -0.6 -0.7
Medication: Ramipril 0.4 0.5 2.6 0.5 -0.1 0.3 0.5 0.5 -0.2 0.6 1.6
Medication: Simvastatin 0.4 0.5 1.2 -1.1 0.3 -0.2 -1.1 -0.4 -0.8 -0.1 1.0
Fluid intelligence score 0.5 1.0 2.7 0.0 0.8 1.4 -1.0 -1.6 0.3 -1.2 0.2
Illnesses of siblings 0.4 0.6 2.0 -1.3 0.5 1.4 0.2 0.0 -0.1 -0.2 -0.8
Neuroticism score 0.8 1.7 5.9 0.7 -0.3 -1.0 -0.9 -2.2 -0.7 -2.4 -0.1
Weight 0.3 1.6 4.0 -0.4 -1.9 0.4 0.4 -1.0 1.5 -1.3 -2.0
Impedance of arm (right) 0.2 0.7 2.1 -1.0 1.4 -0.6 0.9 -0.8 -0.2 -0.9 -0.5
Arm fat percentage (right) 0.3 1.3 2.7 -0.0 -1.6 -1.0 -0.4 -1.1 1.1 -1.3 -1.5
Trunk fat-free mass 0.3 1.5 3.8 -0.7 -1.5 1.6 1.4 0.2 2.0 -0.2 -1.0
Hip circumference 0.4 1.6 3.7 0.3 -1.2 0.9 -0.5 -1.5 1.2 -1.7 -1.9
Time employed in main current job 0.4 0.5 1.3 -0.5 -0.3 -0.2 -1.0 -1.2 -0.1 -1.1 0.3
Alcohol intake versus 10 years previously 0.6 0.9 1.9 -1.2 0.0 0.7 1.0 -1.0 1.4 -1.1 -0.1
Father’s age at death 2.6 3.4 13.5 0.1 -1.7 2.4 1.6 0.4 3.7 0.4 -1.4
Worrier / anxious feelings 1.3 2.5 7.7 0.4 0.5 1.4 -0.4 -2.8 0.0 -2.6 -1.7
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 3.3 1.2 -1.6 -1.8 1.7 0.8 1.0 0.7 0.6
Falls in the last year 0.3 0.5 1.4 -0.0 0.3 0.5 1.2 -0.7 0.6 -0.6 0.8
Hair/balding pattern: Pattern 3 0.3 0.5 1.9 -0.4 -0.6 1.4 -0.5 0.0 1.1 0.0 0.1
Number of live births 0.4 0.5 1.2 -0.2 -0.7 0.5 -0.2 0.8 1.0 1.1 -0.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.5 0.3 -0.5 -0.3 -0.1 -0.5 0.1 -0.7 -0.5
Pulse rate 0.6 0.9 5.4 0.8 -2.3 0.2 -0.9 0.5 0.4 0.4 -0.4
Happiness 0.8 0.9 2.6 -0.1 0.4 0.5 -0.1 1.4 -1.6 1.0 1.2
Noisy workplace 1.4 1.8 3.6 -1.7 -0.4 -1.3 1.9 1.9 0.0 1.3 0.9
Qualifications: A levels/AS levels or equivalent 0.6 1.3 5.4 -0.0 0.7 0.4 0.2 -1.8 -1.0 -2.3 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.5 1.2 0.5 -1.0 0.2 -1.0 -0.4 -0.9 -0.2
Mouth/teeth dental problems: Dentures 0.7 1.2 7.7 -0.4 -1.0 0.3 2.8 -0.5 0.4 -0.5 0.2
Asthma 0.9 1.7 7.6 2.8 0.0 -0.5 -1.2 1.3 -0.2 1.5 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.6 -1.9 -1.8 0.4 -0.6 -0.1 0.1 -0.2 0.9
Medication: Cholesterol lowering 0.6 1.0 2.8 -0.9 0.2 1.1 -1.7 -0.8 -1.3 -0.7 0.5
Depression (self-reported) 1.6 1.9 5.5 0.1 -1.6 -1.2 0.0 -1.4 -2.4 -1.8 -0.7
Medication: Lansoprazole 0.7 0.8 1.6 1.3 1.1 0.6 -1.2 0.7 -0.1 1.1 0.6
Prospective memory result 0.4 0.5 2.9 -1.2 0.1 -1.7 0.2 -0.1 -0.2 -0.1 0.2
Lung cancer (father) 0.5 0.6 1.7 -0.4 1.3 1.0 -0.6 -0.0 -1.1 0.0 -0.4
Illnesses of mother 0.6 0.7 1.9 -0.6 -1.2 -1.4 0.9 0.7 -0.0 0.3 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 1.0 0.1 -0.8 -0.3 -0.3 -0.3 -0.3 -0.8 -1.0
Pulse wave Arterial Stiffness index 0.7 0.8 2.2 0.4 1.5 -0.2 -1.2 -0.1 -1.2 -0.2 -0.9
Impedance of arm (left) 0.1 0.6 1.6 -1.0 1.3 -0.7 0.9 -0.5 -0.4 -0.5 0.0
Arm fat mass (right) 0.3 1.3 2.9 -0.2 -1.6 -0.2 -0.1 -1.2 1.3 -1.4 -1.7
Trunk predicted mass 0.3 1.6 3.8 -0.7 -1.6 1.7 1.5 0.1 2.0 -0.2 -0.9
Standing height 0.3 2.9 6.9 -2.3 0.3 2.6 2.3 -0.9 0.8 -1.2 -1.9
Length of working week for main job 1.1 1.2 2.4 -1.1 0.4 0.3 -1.4 -1.5 -0.9 -1.1 1.2
Exposure to tobacco smoke at home 0.7 0.8 1.7 1.1 -1.3 -0.4 -0.4 0.9 0.2 1.2 1.1
Breastfed as a baby 0.5 0.6 1.4 1.0 0.5 0.8 -0.1 -1.2 -0.2 -1.1 -0.1
Tense / ‘highly strung’ 1.8 3.0 6.3 0.3 0.6 -1.1 -2.3 -2.5 -2.1 -2.5 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.3 2.7 0.3 -1.4 -1.0 -0.6 -1.4 -1.6 -1.6 -0.4
Hair/balding pattern: Pattern 4 2.4 5.8 19.4 -0.5 0.2 -0.1 2.1 4.3 0.5 4.4 1.9
Birth weight of first child 0.5 1.0 4.8 -0.5 -0.2 2.2 -0.7 0.4 -1.1 0.1 -1.0
Peak expiratory flow (PEF) 0.2 0.4 1.2 1.1 -0.1 0.3 -0.8 -0.6 -0.1 -1.1 -0.1
Pulse wave reflection index 0.5 0.6 3.0 -0.5 0.5 -0.7 0.1 -0.4 -1.7 -1.0 0.1
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.4 -0.8 -0.8 -0.2 0.3 -1.4 -1.2 -1.5 -0.5
Loud music exposure frequency 0.2 0.2 0.6 -0.6 0.2 -0.3 -0.7 -0.1 -0.8 -0.3 -0.5
Qualifications: O levels/GCSEs or equivalent 1.2 1.8 5.3 0.5 0.3 2.2 -0.3 -1.9 0.5 -2.3 0.8
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.0 0.7 -1.2 0.8 0.5 -1.4 -0.3 -1.1 -0.0
Blood clot in the leg (DVT) 2.4 3.1 7.7 -0.3 2.0 -0.8 -2.8 -2.0 -2.4 -1.6 -0.3
Medication: Paracetamol 1.2 1.9 4.4 -1.3 -1.3 -1.6 -0.2 -1.9 -0.1 -2.1 1.2
Headache pain in last month 1.0 1.7 9.9 -1.3 -3.1 -0.9 0.6 0.2 0.8 0.0 0.6
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 2.7 1.2 -1.0 -0.9 1.5 1.6 1.3 1.2 0.5
Glaucoma (self-reported) 0.6 0.7 3.8 0.1 -0.6 1.1 1.9 0.3 0.4 0.2 -0.1
Gout (self-reported) 0.7 1.0 3.3 0.9 0.7 1.3 -1.0 0.3 -1.8 0.4 0.7
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.0 0.6 -0.1 1.4 1.1 0.8 -0.4 0.9 0.8
Medication: Amlodipine 0.2 0.3 0.8 -0.5 -0.3 0.2 -0.9 -0.6 -0.3 -0.2 -0.9
Medication: Ventolin 100micrograms inhaler 1.6 2.1 5.6 2.0 -0.6 0.3 -1.8 -0.0 -1.9 -0.1 -2.4
Birth weight 0.4 0.9 2.9 -1.7 -0.7 0.6 -0.4 -0.1 -1.0 -0.3 -1.5
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.5 0.7 0.1 0.5 0.5 1.2 0.5 1.1 -0.8
High blood pressure (siblings) 0.5 0.8 3.6 1.9 -1.1 -1.1 -0.1 -0.2 0.2 0.1 0.0
Forced vital capacity (FVC), Best measure 0.1 0.2 0.8 0.2 -0.5 -0.1 0.1 -0.5 -0.0 -0.9 -0.6
Body fat percentage 0.4 1.5 3.1 0.3 -1.6 -0.8 -0.7 -1.6 0.4 -1.6 -1.8
Leg fat percentage (right) 0.4 1.5 2.6 0.9 -1.5 -0.8 -1.3 -1.5 0.4 -1.4 -1.6
Arm fat-free mass (right) 0.3 1.5 3.9 -0.2 -1.7 2.0 0.8 -0.4 1.3 -0.6 -1.6
Exposure to tobacco smoke outside home 0.4 0.5 1.9 1.4 -0.6 -1.1 -0.2 0.0 -0.6 0.1 -0.3
Comparative body size at age 10 0.3 0.9 5.7 1.1 -2.4 0.1 -0.6 0.1 -0.0 -0.1 -0.3
Number of full brothers 1.2 1.5 3.2 0.0 0.5 0.6 -1.6 -1.8 -1.3 -1.5 -1.3
Worry too long after embarrassment 0.6 1.0 5.9 -0.0 -2.4 0.0 0.9 -0.1 0.7 -0.5 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 4.1 -1.0 -1.6 -1.3 -0.7 -0.7 -2.0 -1.0 -0.8
Wheeze or whistling in the chest in last year 1.8 3.2 5.1 2.0 -1.5 -1.9 1.6 2.2 1.6 2.1 0.7
Number of children fathered 1.4 1.6 7.2 -0.9 0.8 1.2 -1.5 0.6 -2.7 0.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.2 -0.1 -0.9 1.1 0.6 -0.3 -1.5 -0.4 -0.3
Age at first live birth 0.7 1.3 3.8 -0.1 1.5 1.6 -1.9 -0.8 -0.1 -0.8 -0.6
Pulse wave peak to peak time 0.5 0.6 1.5 -0.7 -1.2 0.6 1.1 0.0 1.0 0.1 0.6
Health satisfaction 0.9 1.2 7.8 2.8 -0.3 -0.5 0.2 -0.5 -0.2 -0.9 -0.1
Shortness of breath walking on level ground 0.3 0.3 1.3 1.2 0.0 0.6 -0.0 -0.2 -0.8 -0.1 0.4
Qualifications: College or University degree 0.4 1.2 2.7 0.3 0.4 1.0 -1.6 -1.5 -0.8 -1.3 -0.8
Eye problems/disorders: None of the above 0.8 0.9 4.6 0.7 -0.0 -1.2 -2.1 0.2 -0.9 0.1 -0.1
Mouth/teeth dental problems: Loose teeth 1.5 1.8 4.2 -0.6 -0.5 1.8 1.2 -1.2 -1.1 -1.3 2.0
Emphysema/chronic bronchitis 0.4 0.5 1.5 -0.5 -1.2 -0.2 -0.1 -0.4 0.7 -0.8 -0.8
Medication for pain relief, constipation, heartburn 0.8 1.3 4.0 1.4 1.7 0.7 0.7 -0.4 0.6 -0.3 -2.0
Neck or shoulder pain in last month 1.1 1.6 7.6 -0.3 -0.2 -0.8 -2.8 -0.7 -1.7 -1.0 -0.4
Medication: Blood pressure 0.6 1.0 5.0 -2.2 0.8 0.0 -0.2 -1.2 0.1 -0.6 -1.0
Angina (self-reported) 0.4 0.5 1.2 -1.1 1.0 -0.4 0.8 0.2 1.1 0.4 0.2
Migraine (self-reported) 0.8 0.9 3.2 0.5 -0.5 0.1 0.9 1.2 1.8 1.0 -0.6
Medication: Ibuprofen 1.0 1.2 5.4 -2.3 -1.0 0.0 -0.5 0.7 -0.1 0.5 1.4
Medication: Allopurinol 1.0 1.4 8.1 2.9 -0.5 1.3 -0.6 -0.3 -0.7 -0.2 -0.3
Medication: Omeprazole 0.5 0.5 2.6 0.3 0.9 -1.6 -0.6 -0.0 0.5 0.2 0.4
Medication: Seretide 50 evohaler 0.9 1.0 3.5 1.1 0.6 -0.6 -1.6 0.4 -1.9 0.1 -0.3
Mean time to correctly identify matches 1.7 3.3 8.5 0.7 -2.8 0.4 2.0 2.9 -0.7 2.3 -0.4
Heart disease (mother) 1.3 1.5 3.4 1.9 0.9 0.6 -1.9 -1.4 -0.7 -1.1 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 2.1 -0.7 1.4 0.7 -1.2 -0.1 -1.4 0.1 1.3
Whole body fat mass 0.4 1.5 3.2 0.1 -1.8 0.1 -0.2 -1.4 0.9 -1.6 -1.8
Leg fat mass (right) 0.4 1.7 4.1 0.5 -1.7 -0.0 -0.7 -1.6 1.0 -1.6 -2.0
Arm predicted mass (right) 0.3 1.5 3.8 -0.3 -1.9 1.9 0.8 -0.2 1.5 -0.3 -1.3
Pulse rate, automated reading 0.4 1.4 6.9 0.2 -2.6 1.2 -0.8 -0.2 -0.3 -0.5 -1.3
Alcohol intake frequency. 0.8 1.8 4.7 0.1 -1.1 -1.4 0.8 1.4 1.2 1.5 2.2
Comparative height size at age 10 0.1 0.7 1.9 -0.5 0.8 1.4 1.3 0.1 -0.2 -0.2 -1.1
Number of full sisters 1.7 2.1 5.4 -0.7 1.5 0.6 -0.7 -2.3 -1.6 -2.3 -0.1
Suffer from ‘nerves’ 0.9 1.5 4.4 0.1 -1.4 -0.7 -0.5 -2.1 -0.0 -2.0 0.7
Overall health rating 0.9 1.9 5.8 1.0 -1.7 -1.3 1.6 0.2 1.1 -0.1 2.4
Chest pain or discomfort 1.0 1.4 3.7 1.1 1.1 -1.5 1.2 -0.0 1.9 0.0 -1.2
Had major operations 0.4 0.4 0.7 -0.8 -0.7 0.4 0.6 -0.6 -0.6 -0.7 0.9
Age at last live birth 0.6 0.9 2.2 0.3 1.4 1.5 -1.2 -0.6 0.6 -0.3 0.7
Family relationship satisfaction 0.2 0.2 1.0 0.4 -0.4 0.3 -0.1 -0.0 -0.7 -0.2 1.0
Leg pain on walking 0.9 1.2 3.5 0.4 -1.1 -1.9 0.2 -1.4 -0.6 -1.4 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.9 -0.5 1.7 -0.5 -1.3 -0.5 -1.2 -0.3 0.5
Commuting to job workplace: Car/motor vehicle 1.7 1.9 4.2 2.0 -0.1 1.6 -1.2 -1.6 -0.4 -1.7 1.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.4 -0.8 -0.1 0.6 -1.5 0.8 -0.6 1.1 -0.3
Medication: Aspirin 0.7 1.0 2.3 1.5 -1.1 1.2 0.0 1.2 0.4 1.2 0.1
Supplements: Vitamin C 1.4 1.7 3.4 -1.4 0.9 1.0 0.4 -1.7 -1.7 -1.9 -0.1
Knee pain experienced in last month 0.3 0.4 0.9 0.0 -0.8 -0.7 -0.6 -0.7 -0.9 -0.6 0.2
Hypertension (Self-reported) 0.5 1.4 3.9 -1.8 0.2 0.6 -0.3 -2.0 -0.8 -1.4 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.6 6.1 0.3 -0.0 2.5 -1.1 0.9 1.5 1.4 0.4
Illnesses of father: Heart disease 0.5 0.7 1.5 0.7 -0.2 -0.8 0.8 0.9 0.5 1.2 -1.2
Illnesses of siblings: Diabetes 0.2 0.3 0.9 0.3 0.2 0.1 -1.0 0.6 -0.4 0.7 0.2
Smoking status: Previous 0.9 1.4 5.0 -0.6 0.3 1.2 1.7 -0.4 0.8 -0.6 -2.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 3.8 -2.0 -0.3 0.2 0.5 -0.0 -0.4 -0.4 -0.1
Whole body fat-free mass 0.3 1.6 3.6 -0.7 -1.9 1.4 1.3 -0.2 1.8 -0.5 -1.1
Leg fat-free mass (right) 0.3 1.4 5.3 -0.8 -2.3 0.5 1.1 -0.4 1.4 -0.9 -0.9
Arm fat percentage (left) 0.3 1.2 3.7 0.1 -1.9 -1.0 -0.5 -1.0 1.1 -1.1 -1.4
Average weekly red wine intake 0.8 1.1 4.1 0.6 0.2 0.1 -2.0 -0.4 -1.8 -0.8 0.5
Handedness (chirality/laterality): Left-handed 1.0 1.2 5.1 -0.4 -0.8 -2.2 0.7 -0.4 1.8 -0.3 -0.1
Mood swings 0.4 0.8 1.7 1.3 0.3 -1.1 -0.8 -0.4 -1.0 -0.8 1.0
Loneliness, isolation 0.5 0.7 3.1 0.6 -0.5 0.6 -0.5 -0.6 -1.8 -0.9 0.6
Long-standing illness, disability or infirmity 0.3 0.4 1.2 0.6 -0.1 -0.6 -0.4 0.9 0.5 1.1 0.6
Ever had bowel cancer screening 1.4 1.6 6.8 0.4 0.2 -1.6 -2.6 -0.7 -1.6 -0.4 0.2
Diabetes diagnosed by doctor 1.0 1.6 4.4 -1.7 1.7 2.1 -0.5 0.8 0.2 1.0 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 8.2 -0.7 -0.5 2.9 0.6 0.2 2.3 0.3 -0.3
Friendships satisfaction 0.1 0.1 0.6 -0.1 -0.0 0.2 0.7 -0.1 0.2 -0.7 0.0
Qualifications: nursing, teaching 0.8 1.3 4.8 0.6 -0.8 0.8 -1.1 -1.0 -2.2 -1.1 -0.7
Commuting to job workplace: Walk 1.2 1.2 7.7 -2.8 0.5 -0.4 0.1 -0.0 0.2 0.0 -1.3
Eye problems/disorders: Cataract 0.8 0.9 2.1 0.2 -1.3 -0.6 0.9 -1.2 0.5 -1.5 0.8
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.9 1.8 -0.7 0.7 -0.0 -0.2 0.5 -0.7 -2.0
Medication for cholesterol 0.6 0.9 2.0 -0.5 -0.7 1.4 1.3 0.8 1.4 0.2 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 3.0 -0.5 0.5 -1.7 -0.8 -1.4 -1.7 -1.6 0.9
Back pain experienced in last month 0.4 0.6 1.2 1.1 0.5 -0.7 0.7 1.0 -1.0 0.6 0.3
Mineral and other dietary supplements 0.7 1.0 2.0 -0.6 0.6 -0.6 -0.2 1.3 1.1 1.4 1.3
Breast cancer (self-reported) 0.4 0.5 2.0 -0.3 0.9 0.5 0.4 0.9 -0.4 1.4 -0.0
Asthma (self-reported) 0.9 1.9 8.0 2.8 0.1 -0.7 -1.5 1.1 -0.5 1.3 -0.9
Osteoporosis (self-reported) 0.5 0.6 1.7 1.3 0.2 -0.6 1.0 0.9 0.2 0.8 0.2
Osteoarthritis (self-reported) 0.9 1.1 3.8 -0.7 -1.8 -2.0 -0.5 -0.1 -0.6 -0.3 -0.9
Medication: Aspirin 0.9 1.2 2.3 1.2 -1.2 1.1 0.7 1.5 0.7 1.5 -0.3
Medication: Gliclazide 0.8 0.9 2.6 1.6 0.7 -0.9 -1.2 -0.7 0.3 -0.4 -1.0
Illnesses of father: None of the above (group 1) 0.7 0.8 4.0 0.3 0.5 2.0 -0.6 -0.7 -0.3 -0.9 0.8
Smoking status: Current 0.3 0.4 1.5 0.6 -1.2 -0.8 0.2 0.6 0.5 0.1 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 3.0 1.1 -1.7 -1.7 -0.1 -0.5 -0.4 -0.6 1.3
Whole body water mass 0.3 1.6 3.7 -0.7 -1.9 1.5 1.3 -0.2 1.8 -0.6 -1.2
Leg predicted mass (right) 0.2 1.3 5.1 -0.7 -2.2 0.5 1.1 -0.4 1.3 -0.8 -0.9
Arm fat mass (left) 0.3 1.2 2.9 -0.0 -1.7 -0.2 -0.1 -1.1 1.3 -1.2 -1.6
Number of self-reported non-cancer illnesses 0.7 1.3 6.8 0.7 0.0 0.1 -1.2 -0.9 -2.6 -0.8 0.3
Average weekly champagne plus white wine intake 0.6 0.8 2.4 -0.2 0.2 0.3 -1.5 -1.1 -0.9 -1.4 0.2
Miserableness 0.7 1.2 3.2 0.1 -1.2 -1.6 1.0 -0.8 0.2 -0.9 1.8
Guilty feelings 1.3 1.9 3.9 -0.9 -2.0 0.2 -0.7 -1.6 -1.1 -1.8 -1.8
Wears glasses or contact lenses 0.7 0.8 4.7 -2.2 -0.5 1.0 -0.3 -0.2 -0.7 -0.2 -0.3
Ever taken oral contraceptive pill 0.6 0.7 2.0 -1.0 1.4 0.0 -0.5 -0.7 -0.6 -0.6 -0.8
Hearing aid user 0.6 0.7 2.0 -1.4 0.2 0.5 -0.4 0.2 -0.9 0.5 1.3
Mother’s age at death 0.7 0.9 1.6 0.3 0.3 1.2 -1.3 0.9 -0.1 1.1 1.3
Financial situation satisfaction 1.8 2.3 9.1 0.5 -0.9 -0.9 1.7 1.3 1.1 1.2 3.0
Tinnitus: Yes, now most or all of the time 1.9 2.2 5.0 0.5 1.4 1.4 -2.0 0.7 -2.2 1.2 1.5
Commuting to job workplace: Public transport 0.8 1.0 3.6 -1.9 -0.2 -0.0 1.1 1.2 0.4 1.1 0.5
Eye problems/disorders: Glaucoma 1.5 1.8 7.4 -0.5 -0.9 2.0 2.7 0.8 0.7 0.8 0.2
Medication: Blood pressure 0.3 0.5 1.0 -0.7 -0.7 0.1 1.0 0.7 0.6 1.0 0.6
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 -0.1 -0.4 -0.9 0.1 -0.9 -0.3 -0.7 0.1
Supplements: Fish oil (including cod liver oil) 1.0 1.4 3.7 0.8 -0.2 1.5 -0.4 -1.4 -0.7 -1.2 -1.9
High cholesterol (Self-reported) 0.6 1.0 3.1 -0.4 1.8 0.7 -0.7 -0.5 -1.2 -0.0 1.5
Medication: Bendroflumethiazide 0.3 0.5 1.9 -1.1 0.3 -0.3 0.2 -0.4 0.7 0.0 -1.4
Medication: Paracetamol 1.0 1.5 3.1 -1.6 -0.7 -1.8 -0.3 -1.6 -0.8 -1.7 0.2
Medication: Lisinopril 1.0 1.3 4.7 -2.2 -0.0 0.1 1.5 0.6 1.5 0.9 -0.2
Medication: Atorvastatin 0.5 0.7 2.5 0.0 0.9 0.5 -0.2 -0.4 1.3 -0.2 -1.6
Illnesses of father: High blood pressure 0.6 0.7 3.6 -0.4 -0.4 -0.7 -0.2 -0.8 0.6 -0.7 -1.9
Alcohol drinker status: Never 2.2 2.6 9.9 -0.8 0.7 -0.5 0.4 2.0 0.5 2.2 3.1
Ever smoked 0.8 1.3 6.4 0.1 0.0 0.2 0.4 -1.1 0.3 -1.7 -2.5
Basal metabolic rate 0.3 1.5 3.7 -0.7 -1.9 1.1 1.1 -0.4 1.8 -0.7 -1.3
Leg fat percentage (left) 0.6 2.0 3.9 1.0 -1.3 -0.7 -1.6 -1.9 -0.1 -2.0 -1.6
Arm fat-free mass (left) 0.3 1.5 3.3 -0.4 -1.4 1.7 0.7 -0.6 1.4 -0.9 -1.8
Number of operations (self-reported) 0.8 1.2 3.8 -0.5 0.2 -0.7 0.6 -1.6 -1.5 -2.0 -0.1
Average weekly beer plus cider intake 1.1 1.6 7.0 -0.6 -1.3 -1.3 2.6 0.9 0.0 0.6 1.1
Irritability 1.8 3.0 6.8 0.8 0.7 -0.3 -2.6 -2.4 -2.1 -2.3 -0.7
Risk taking 0.2 0.3 1.2 0.2 0.2 0.1 1.1 0.5 -0.5 0.3 0.9
Ever had prostate specific antigen (PSA) test 2.0 2.3 6.7 -1.1 0.9 1.4 -2.6 -0.4 -2.2 -0.2 -1.5
Fractured/broken bones in last 5 years 0.4 0.5 1.4 0.7 0.5 -0.1 0.6 0.6 1.2 0.2 -1.1
Age started oral contraceptive pill 0.7 0.9 3.1 0.0 0.1 1.8 0.5 1.2 -0.2 1.5 -0.3
Diastolic blood pressure, automated reading 1.0 3.0 11.4 0.5 -3.4 -0.3 1.5 -1.3 1.3 -1.7 -1.9
Ever depressed for a whole week 1.9 2.4 9.2 -0.4 -1.3 -1.4 1.7 1.4 0.5 0.8 3.0
Unable to work because of sickness or disability 0.1 0.2 0.6 0.3 -0.1 -0.4 0.7 -0.2 0.0 -0.1 0.8
Commuting to job workplace: Cycle 1.6 2.0 4.7 -1.2 0.3 0.2 1.6 1.6 0.6 2.0 2.2
Myopia 0.9 1.3 3.3 1.7 -0.0 -1.5 0.1 -1.4 0.4 -1.8 -0.6
Vascular/heart problems diagnosed by doctor 0.4 1.0 3.4 1.8 -0.3 -0.8 0.2 1.6 0.6 1.0 -0.2
Cholesterol lowering medication 0.6 0.9 2.8 1.1 0.2 -0.7 1.0 0.8 0.2 1.1 1.7
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.2 0.0 0.9 -1.1 -0.5 -0.0 0.5 0.4 0.9
Pain experienced in last month 0.7 1.2 3.4 -0.5 1.1 0.4 0.5 1.8 0.9 1.8 -0.3
Supplements: Calcium 1.0 1.1 2.3 1.5 0.7 -0.9 0.3 1.5 0.2 1.5 -0.6
Basal cell carcinoma (self-reported) 0.4 0.5 2.1 0.5 -0.6 0.3 1.0 0.3 0.4 -0.2 -1.4
Heart attack/myocardial infarction (self-reported) 0.7 0.8 2.8 1.7 -0.2 0.3 -1.0 -0.8 -1.4 -0.5 0.5
Deep venous thrombosis (DVT) (self-reported) 2.8 3.6 8.3 0.0 2.2 -1.0 -2.9 -2.2 -2.5 -1.8 -0.2
Heart disease (siblings) 0.5 0.6 1.5 1.2 -1.0 0.1 1.1 -0.4 0.8 -0.2 -0.3
Alcohol drinker status: Previous 0.1 0.1 0.2 0.3 -0.4 0.3 0.4 0.1 0.5 0.3 -0.1
Pack years of smoking 0.4 0.5 0.9 -0.5 -1.0 0.8 -0.4 0.9 0.1 0.8 -0.9
Impedance of whole body 0.2 0.9 4.0 -0.5 2.0 0.1 0.3 -1.0 -1.0 -1.0 -0.6
Leg fat mass (left) 0.5 1.8 3.8 0.5 -1.5 0.0 -0.9 -1.8 0.6 -1.9 -1.9
Arm predicted mass (left) 0.3 1.3 2.9 -0.1 -1.4 1.6 0.9 -0.4 1.3 -0.7 -1.7