Best TWAS P=8.33e-09 · Best GWAS P=4.26e-08 conditioned to 0.0481
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | NOA1 | 0.17 | 0.06 | lasso | 4 | 0.06 | 3.5e-04 | 4.6 | -5.3 | 1.4e-07 | 0.71 | 0.03 | 0.93 | FALSE |
| 2 | GTEx | Muscle Skeletal | REST | 0.05 | 0.01 | enet | 9 | 0.02 | 3.9e-03 | -4.2 | -5.5 | 5.1e-08 | 0.74 | 0.04 | 0.94 | FALSE |
| 3 | METSIM | Adipose | RP11-738E22.3 | 0.07 | 0.04 | lasso | 6 | 0.05 | 7.7e-08 | -4.9 | 5.4 | 6.7e-08 | -0.78 | 0.03 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf14 | 0.03 | 0.04 | lasso | 3 | 0.04 | 1.9e-05 | -5.3 | -5.3 | 1.2e-07 | 0.82 | 0.01 | 0.97 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | REST | 0.04 | 0.01 | lasso | 5 | 0.02 | 7.8e-04 | -5.0 | -5.8 | 8.3e-09 | 0.71 | 0.03 | 0.83 | TRUE |