Best TWAS P=2.42e-53 · Best GWAS P=5.81e-77 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C4orf22 | 0.09 | 0.08 | lasso | 5 | 0.07 | 4.5e-09 | 11.6 | 11.9 | 9.4e-33 | 0.01 | 1.00 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | FGF5 | 0.07 | 0.06 | lasso | 2 | 0.05 | 5.4e-07 | 11.6 | 10.8 | 2.1e-27 | 0.03 | 0.89 | 0.00 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | ANXA3 | 0.05 | -0.01 | enet | 4 | -0.01 | 5.7e-01 | 8.7 | -8.9 | 7.8e-19 | 0.42 | 0.04 | 0.10 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | FRAS1 | 0.21 | 0.00 | enet | 31 | 0.01 | 5.0e-02 | -16.8 | -7.0 | 2.3e-12 | 0.35 | 0.26 | 0.03 | FALSE |
| 5 | GTEx | Colon Sigmoid | FRAS1 | 0.19 | 0.01 | enet | 22 | 0.01 | 2.0e-01 | 7.2 | 10.5 | 6.4e-26 | -0.49 | 0.07 | 0.41 | FALSE |
| 6 | GTEx | Esophagus Muscularis | ANXA3 | 0.29 | 0.23 | enet | 20 | 0.29 | 8.5e-18 | 6.9 | -5.4 | 8.4e-08 | 0.27 | 1.00 | 0.00 | TRUE |
| 7 | GTEx | Muscle Skeletal | FRAS1 | 0.11 | 0.06 | enet | 9 | 0.08 | 6.3e-08 | -13.4 | -13.1 | 5.2e-39 | 0.64 | 0.91 | 0.09 | TRUE |
| 8 | GTEx | Nerve Tibial | FRAS1 | 0.36 | 0.18 | enet | 33 | 0.28 | 2.8e-20 | -13.7 | 15.4 | 2.4e-53 | -0.66 | 1.00 | 0.00 | TRUE |
| 9 | GTEx | Nerve Tibial | ANXA3 | 0.40 | 0.16 | enet | 26 | 0.30 | 9.0e-22 | 5.5 | 8.6 | 5.6e-18 | -0.45 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | ANXA3 | 0.12 | 0.07 | lasso | 7 | 0.06 | 4.6e-04 | -12.4 | -9.8 | 6.6e-23 | 0.50 | 0.23 | 0.29 | TRUE |
| 11 | GTEx | Stomach | FRAS1 | 0.11 | -0.01 | enet | 24 | 0.01 | 7.7e-02 | 5.1 | 7.0 | 3.6e-12 | -0.35 | 0.14 | 0.27 | TRUE |
| 12 | METSIM | Adipose | BMP2K | 0.04 | 0.02 | enet | 29 | 0.03 | 2.7e-05 | -4.3 | 5.6 | 2.2e-08 | -0.23 | 0.93 | 0.00 | TRUE |
| 13 | METSIM | Adipose | CNOT6L | 0.09 | 0.03 | blup | 529 | 0.05 | 1.2e-07 | -3.0 | 7.6 | 2.3e-14 | -0.32 | 1.00 | 0.00 | TRUE |
| 14 | NTR | Blood | BMP2K | 0.02 | 0.00 | blup | 447 | 0.00 | 4.3e-02 | 4.2 | 12.7 | 6.0e-37 | -0.56 | 0.17 | 0.18 | TRUE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ANXA3 | 0.04 | 0.02 | lasso | 3 | 0.01 | 2.7e-03 | 5.5 | -6.5 | 9.2e-11 | 0.31 | 0.36 | 0.01 | TRUE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ANXA3 | 0.02 | 0.02 | blup | 93 | 0.02 | 2.4e-03 | 2.8 | -9.3 | 1.3e-20 | 0.43 | 0.10 | 0.05 | TRUE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SHROOM3 | 0.05 | 0.03 | enet | 7 | 0.02 | 9.0e-04 | 5.6 | -6.2 | 7.1e-10 | 0.06 | 0.57 | 0.19 | TRUE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FRAS1 | 0.11 | 0.05 | enet | 14 | 0.06 | 8.7e-08 | 8.3 | -7.4 | 1.6e-13 | 0.33 | 0.94 | 0.01 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | C4orf22 | 0.03 | 0.02 | blup | 200 | 0.02 | 8.3e-04 | -6.6 | -7.3 | 2.0e-13 | -0.01 | 0.78 | 0.01 | TRUE |
| 20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FRAS1 | 0.09 | 0.04 | lasso | 4 | 0.04 | 5.1e-04 | 7.6 | 9.5 | 2.8e-21 | -0.38 | 0.80 | 0.03 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FRAS1 | 0.04 | 0.02 | lasso | 6 | 0.03 | 5.2e-04 | 6.2 | 6.1 | 9.3e-10 | -0.25 | 0.17 | 0.11 | FALSE |