Best TWAS P=6.17e-22 · Best GWAS P=4.91e-24 conditioned to 0.000944
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | E2F3 | 0.05 | 0.00 | bslmm | 538 | 0.01 | 3.0e-02 | -6.1 | -9.0 | 2.4e-19 | 0.63 | 0.04 | 0.77 | FALSE |
| 2 | GTEx | Brain Nucleus accumbens basal ganglia | E2F3 | 0.30 | 0.04 | lasso | 12 | 0.06 | 1.2e-02 | 4.4 | -5.7 | 9.6e-09 | 0.46 | 0.13 | 0.29 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | CDKAL1 | 0.13 | -0.01 | enet | 24 | 0.00 | 1.8e-01 | 4.1 | 5.2 | 2.7e-07 | -0.42 | 0.12 | 0.09 | FALSE |
| 4 | GTEx | Thyroid | CDKAL1 | 0.10 | 0.07 | lasso | 4 | 0.08 | 1.9e-06 | -8.7 | 9.6 | 6.2e-22 | -0.90 | 0.02 | 0.98 | TRUE |