Hub : Genes

E2F3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0450	0.0200	3.8e-03	0.000	0.008	0.000	0.008	0.000	3.1e-01	3.6e-02	3.6e-01	3.0e-02	2.8e-01
2	GTEx	Brain Nucleus accumbens basal ganglia	0.3010	0.0840	9.1e-05	0.040	NA	0.013	NA	0.057	3.1e-02	NA	1.4e-01	NA	1.2e-02
3	NTR	Blood	0.0372	0.0122	6.3e-05	0.021	0.018	0.037	0.028	0.034	2.2e-07	1.1e-06	5.9e-12	1.3e-09	4.5e-11
4	YFS	Blood	0.0649	0.0184	2.0e-06	0.025	0.021	0.042	0.036	0.039	9.7e-09	1.0e-07	1.3e-13	5.6e-12	7.0e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	2.0	-0.1	0.1	-0.4	-1.4
Bipolar Disorder or Schizophrenia	0.9	2.1	4.2	1.4	2.1	1.4	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.6	0.3	-0.4	-0.0
Depression (Nagel 2018)	1.3	2.0	6.3	0.1	2.5	-1.0	-0.7
Intelligence (Savage-Jansen 2018)	1.5	4.8	11.1	-2.5	-3.3	-1.1	0.5
Neuroticism (Nagel 2018)	0.6	1.5	2.8	-1.6	-1.7	-0.7	-0.2
Schizophrenia (2018)	2.0	4.1	6.5	1.9	2.5	2.1	1.4
Schizophrenia vs Biploar Disorder	1.5	2.0	3.8	1.7	0.7	2.0	0.9
Worry (Nagel 2018)	0.5	1.1	2.7	-0.5	-0.7	-1.6	-0.9
Alzheimer’s Disease (in mother)	1.3	1.6	5.1	0.1	-0.3	-2.3	-1.0
Alzheimer’s Disease (in father)	0.7	0.8	2.0	0.6	1.4	-0.3	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	3.1	0.7	1.2	-1.8	-1.2
Crohns Disease (2017)	1.5	3.4	8.9	3.0	0.7	0.4	2.0
Irritable Bowel Disease (IBD)	0.7	1.8	5.0	2.2	-0.2	-0.4	1.4
Ulcerative Colitis (UC)	0.2	0.4	0.9	0.4	-0.9	-0.5	0.3
Major Depression (MDD)	0.6	0.8	1.7	-1.0	0.3	-0.5	-1.3
Reaction Time	0.5	1.0	3.4	0.1	1.8	-0.6	-0.4
Verbal and Numeric Reasoning (VNR)	0.9	2.3	4.1	-1.9	-2.0	-1.1	0.5
Breast Cancer	3.5	8.4	17.7	3.2	1.9	-4.2	-1.4
Ovarian Cancer	0.8	1.1	3.2	0.1	-1.1	-1.8	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.3	1.9	5.1	-0.4	-2.2	-1.3	0.9
Bipolar Disorder (2011)	0.7	0.6	1.2	1.1	1.1	0.4	-0.1
Body Mass Index (BMI) (2010)	1.0	1.4	2.2	-1.4	-1.1	-1.5	0.1
Coronary Artery Disease (CAD)	1.4	1.6	3.4	-1.8	-1.1	-0.1	1.3
Crohns Disease (2012)	2.7	4.3	9.5	3.1	0.4	1.2	2.5
Mean Putamen Volume	0.8	0.9	2.5	-0.8	-1.6	0.6	-0.2
Fasting Glucose	4.6	5.5	14.1	-2.1	-3.8	1.8	-0.3
HbA1C	5.3	5.9	12.6	-3.3	-3.6	0.1	-0.3
HDL Cholesterol	0.4	0.7	2.3	-0.4	0.6	-1.5	0.3
LDL Cholesterol	0.1	0.2	0.3	-0.6	0.4	0.4	0.5
Lupus	0.3	0.4	0.7	0.0	-0.8	-0.6	-0.7
Neuroticism (2016)	0.3	0.5	0.7	0.7	0.0	-0.9	-0.8
Primary Biliary Cirrhosis	0.5	0.7	2.5	0.0	0.3	1.6	0.3
Rheumatoid Arthritis	1.0	1.4	2.9	1.1	1.1	-1.7	0.4
Schizophrenia (2014)	1.8	4.0	6.7	1.6	2.5	2.6	0.7
Triglycerides	1.1	1.8	3.7	-1.9	-1.7	0.6	-0.5
Type 2 Diabetes (T2D) (2012)	3.3	3.9	9.6	-3.1	-2.2	-0.8	-0.4
Ulcerative Colitis	0.3	0.4	0.8	0.9	0.1	-0.8	-0.0
Blood Eosinophil Count	0.0	0.4	1.2	-1.1	-0.0	0.3	0.5
Blood Platelet Count	0.7	8.4	25.1	-5.0	-1.9	1.5	1.6
Blood Red Count	0.8	7.4	19.5	-2.7	-1.4	4.4	-1.1
Blood White Count	0.4	2.7	9.7	-3.1	0.1	0.8	0.8
Heel T-Score	0.5	3.8	10.1	1.5	1.4	-3.2	-0.9
BMI	0.4	2.3	6.8	-2.6	-1.2	-0.9	0.7
Height	0.2	4.0	14.3	3.8	0.2	-0.2	1.3
Waist Hip Ratio (WHR)	2.4	11.0	30.9	-5.6	-2.9	2.2	0.1
Systolic Blood Pressure	1.0	5.2	9.0	-3.0	-2.8	2.0	-0.2
Smoking Status	0.5	1.2	1.9	-1.0	-1.3	-0.3	-1.4
Allergy or Eczema	0.6	1.5	3.2	1.6	0.2	0.5	1.8
Cardiovascular Disease	2.4	8.0	19.8	-4.5	-2.6	1.5	1.8
Hypothyroidism (self reported)	0.2	0.4	1.3	0.2	1.1	0.1	0.6
Respiratory disease	0.1	0.2	0.4	0.3	-0.7	0.3	0.1
Type 2 Diabetes (T2D) (2018)	10.9	20.3	43.4	-6.1	-6.6	0.9	-0.5
Lung FEV1/FVC ratio	0.5	2.6	5.2	-1.6	-1.6	0.3	2.3
Lung FVC	0.3	1.5	3.8	0.2	0.5	1.9	1.4
Neuroticism	0.5	1.3	2.5	-1.5	-1.6	-0.7	0.1
Chronotype (morning person)	1.2	2.8	8.6	1.1	2.9	-1.2	0.5
Hair Pigment	1.1	30.6	80.8	-9.0	-5.7	2.8	1.0
Tanning	0.2	1.9	4.5	2.1	1.6	-0.1	-0.5
Hand grip strength (left)	0.6	1.7	4.0	2.0	-0.5	1.6	0.2
Number of treatments/medications taken	3.5	6.2	13.1	-3.6	-3.1	-1.2	0.9
Average weekly spirits intake	0.6	0.7	1.1	0.6	-1.0	-1.0	-0.6
Sensitivity / hurt feelings	1.7	2.9	6.1	-2.5	-1.9	-1.2	0.6
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.2	-1.8	0.5	-0.6	-1.0
Hearing difficulty/problems: Yes	1.5	2.2	4.3	-0.4	-1.4	-1.6	2.1
Relative age of first facial hair	1.9	3.9	11.4	-1.9	-3.4	0.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.2	-0.4	0.2	-1.0	1.1
Ever used hormone-replacement therapy (HRT)	3.4	4.3	11.8	-1.5	-1.6	-3.4	-0.6
Ever had hysterectomy (womb removed)	1.6	1.8	3.6	-1.9	-1.8	-0.4	0.5
Systolic blood pressure, automated reading	0.8	2.2	4.5	-2.1	-2.1	-0.3	0.1
Eye problems/disorders: Diabetes related eye disease	2.8	3.0	6.7	-0.9	-2.1	2.6	0.6
Angina	0.8	1.0	2.7	0.7	1.0	-0.0	1.6
Medication for hormone replacement therapy	0.3	0.4	0.7	0.8	0.1	-0.4	0.9
Vitamin and mineral supplements	1.5	2.1	6.9	0.6	1.0	0.4	2.6
Supplements: Zinc	1.8	2.0	4.6	-1.1	-2.1	-0.5	-1.3
Medication: Co-codamol	0.9	1.1	2.7	-1.0	-0.5	-1.6	0.6
Medication: Metformin	2.8	3.9	8.9	-2.5	-3.0	-0.6	0.7
Diabetes (father)	10.6	13.2	26.1	-4.9	-5.1	1.6	-0.5
Diabetes (mother)	3.6	4.6	8.9	-2.8	-3.0	0.3	1.2
Severe depression (siblings)	0.4	0.5	0.8	-0.9	0.1	-0.6	-0.9
Pack years adult smoking proportion	0.4	0.7	1.1	-0.5	-1.0	1.0	0.6
Impedance of leg (right)	1.5	7.5	15.9	-4.0	-2.8	2.2	-1.2
Leg fat-free mass (left)	0.5	2.7	6.1	2.5	1.6	-1.1	1.0
Trunk fat percentage	1.6	6.4	10.5	-3.2	-2.9	-0.4	2.6
Hand grip strength (right)	1.2	3.2	6.5	2.5	-0.6	2.3	0.9
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.4	0.6	0.2	-0.3
Current tobacco smoking	0.4	0.6	1.3	0.5	0.9	1.1	-0.4
Average weekly fortified wine intake	1.7	2.0	7.6	-0.7	-2.8	0.0	0.2
Maternal smoking around birth	1.0	1.4	2.7	0.6	1.7	-0.0	-1.6
Fed-up feelings	0.2	0.3	0.6	-0.5	0.8	0.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.3	5.8	1.3	2.4	-1.6	-1.8
Relative age voice broke	1.0	1.6	5.1	2.2	-0.5	-1.0	0.0
Taking other prescription medications	1.1	1.6	5.0	-2.2	-0.8	-0.7	0.5
Age when periods started (menarche)	1.8	4.4	14.1	-1.1	-3.8	-1.4	-0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.0	0.4	-0.1	-1.0	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	0.8	1.0	0.2	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.6	-0.5	-1.3	0.1	-0.1
Qualifications: CSEs or equivalent	0.4	0.5	1.9	0.2	1.4	0.2	0.4
Serious illness, injury or assault to yourself	0.6	0.7	2.4	-1.5	-0.6	-0.5	-0.2
High blood pressure	2.7	7.6	19.4	-4.4	-3.1	0.6	1.1
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.8	2.0	0.2	0.8	1.6
Multivitamins +/- minerals	1.4	1.8	6.4	-0.6	-0.4	-0.3	-2.5
Stomach or abdominal pain in last month	0.5	0.6	1.0	0.6	1.0	-0.9	-0.5
Supplements: Glucosamine	1.7	2.2	8.0	-0.8	-0.3	-2.8	-0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	3.1	-1.8	-0.1	-0.6	-0.2
Medication: Atenolol	0.7	0.9	3.3	-1.8	-0.6	0.1	0.2
Medication: Levothyroxine sodium	0.4	0.7	2.2	-0.1	0.6	-1.5	0.3
Sitting height	0.6	4.4	8.5	2.9	2.4	1.3	1.2
Chronic bronchitis/emphysema (father)	0.8	0.9	2.7	0.7	1.6	-0.6	0.0
High blood pressure (mother)	0.7	0.9	1.4	-1.2	-0.4	1.1	1.0
Body mass index (BMI)	0.3	1.1	1.9	-0.8	0.1	-1.4	1.4
Impedance of leg (left)	1.4	6.7	12.3	-3.5	-2.9	2.5	-0.1
Leg predicted mass (left)	0.5	2.8	6.4	2.5	1.6	-1.0	1.0
Trunk fat mass	0.9	3.7	7.0	-2.0	-1.9	-0.4	2.6
Waist circumference	0.4	1.4	2.5	-1.6	-0.9	-0.9	1.2
Number of incorrect matches in round	0.7	1.2	3.3	1.0	-0.3	-1.8	0.7
Past tobacco smoking	1.6	2.9	9.6	1.3	3.1	0.4	0.6
Alcohol usually taken with meals	0.3	0.5	1.3	0.7	-0.1	-1.1	-0.4
Nervous feelings	1.2	2.3	3.1	-1.6	-1.8	-1.2	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.3	-2.1	-1.1	-0.2	-1.1
Hearing difficulty/problems with background noise	0.4	0.6	1.2	-0.3	-1.1	-0.7	0.9
Hair/balding pattern: Pattern 2	2.2	2.8	4.4	0.8	2.1	-1.8	-1.8
Had menopause	0.4	0.5	0.8	0.7	-0.7	-0.9	0.6
Had other major operations	0.3	0.4	0.7	0.5	0.1	-0.8	-0.7
Forced vital capacity (FVC)	0.7	2.9	6.7	1.6	1.0	2.6	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.0	1.5	2.2	0.4	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.6	-1.3	-0.2	-0.6	0.0
Qualifications: None of the above	0.2	0.4	1.3	-0.4	0.4	0.4	1.2
Financial difficulties in last 2 years	1.6	2.1	6.4	-0.0	1.3	-2.5	-0.7
Mouth/teeth dental problems	0.5	0.8	1.3	0.4	0.7	1.0	1.1
Heart attack	0.8	1.0	3.0	-1.7	-0.5	-0.6	-0.5
Allergy	0.6	1.4	2.9	-1.7	-0.1	-1.3	-1.0
Pain all over the body in last month	3.0	3.2	11.4	-3.4	-0.5	-0.5	-1.0
Diabetes (self-reported)	4.0	6.2	14.6	-3.2	-3.8	-0.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.3	1.1	0.1	0.5	1.0
Medication: Ramipril	2.9	3.8	9.7	-3.1	-2.2	-0.8	-0.1
Medication: Simvastatin	1.4	2.0	4.6	-2.1	-1.6	-0.6	0.8
Fluid intelligence score	0.7	1.4	3.6	-1.3	-1.9	-0.1	0.3
Illnesses of siblings	1.1	1.5	4.3	2.1	1.0	-0.5	-0.6
Neuroticism score	0.6	1.3	2.9	-1.7	-1.4	-0.7	-0.2
Weight	0.2	1.0	2.7	0.5	0.1	-0.9	1.6
Impedance of arm (right)	1.4	6.5	17.5	-2.7	-4.2	1.0	-0.6
Arm fat percentage (right)	0.9	3.7	6.3	-2.5	-2.1	-1.2	1.7
Trunk fat-free mass	1.1	6.1	14.4	3.8	3.0	-0.8	0.4
Hip circumference	0.4	1.8	3.1	1.4	0.7	-1.2	1.8
Time employed in main current job	0.8	0.9	1.6	1.3	0.1	1.1	0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.4	-1.2	-0.1	-0.5	0.3
Father’s age at death	0.6	0.7	2.5	0.2	-1.6	-0.4	0.4
Worrier / anxious feelings	0.1	0.3	0.5	-0.3	0.2	-0.7	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	1.8	-1.3	-1.0	-1.1	0.9
Falls in the last year	0.8	1.0	3.1	-0.9	-0.3	1.8	-0.5
Hair/balding pattern: Pattern 3	0.2	0.2	0.7	-0.5	0.2	0.1	0.8
Number of live births	0.3	0.4	0.9	0.1	-0.7	-1.0	-0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.5	0.6	0.7	1.9	1.6
Pulse rate	0.7	1.1	2.3	-0.9	-1.1	1.5	-0.5
Happiness	0.4	0.5	1.5	0.1	-0.6	-1.2	-0.1
Noisy workplace	0.3	0.4	0.6	-0.7	-0.8	0.7	0.3
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.8	-1.6	-2.2	-0.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.4	1.0	1.2	-0.9	0.3
Mouth/teeth dental problems: Dentures	0.7	1.2	2.0	1.0	1.4	-0.7	1.2
Asthma	0.6	1.3	3.9	-0.8	-2.0	0.7	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.6	-1.3	-0.7	0.9	-0.0
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.2	-0.2	0.5	0.9
Depression (self-reported)	0.3	0.3	0.8	-0.3	-0.3	-0.9	0.5
Medication: Lansoprazole	1.9	2.2	4.1	1.8	2.0	0.1	1.1
Prospective memory result	1.0	1.2	2.6	-0.8	-1.6	0.2	-1.2
Lung cancer (father)	2.0	2.3	2.9	1.7	1.6	1.4	1.4
Illnesses of mother	0.6	0.8	2.0	0.7	0.2	-1.4	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	6.7	1.0	0.9	2.6	2.1
Pulse wave Arterial Stiffness index	0.7	0.9	2.3	-0.8	-0.6	-1.5	0.1
Impedance of arm (left)	1.3	5.8	15.3	-2.7	-3.9	0.7	-0.1
Arm fat mass (right)	0.4	1.6	3.0	-1.4	-0.9	-0.8	1.7
Trunk predicted mass	1.1	6.4	15.0	3.9	3.1	-0.9	0.3
Standing height	0.3	2.6	7.6	2.8	0.1	1.3	1.1
Length of working week for main job	0.7	0.8	2.0	0.5	-0.5	1.4	-0.8
Exposure to tobacco smoke at home	0.7	0.8	1.7	-0.0	1.0	-1.3	-0.7
Breastfed as a baby	0.3	0.4	0.6	0.5	0.7	-0.6	0.8
Tense / ‘highly strung’	1.4	2.4	5.2	-0.9	0.2	-1.9	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.9	-1.4	-1.4	0.8	0.5
Hair/balding pattern: Pattern 4	2.8	6.8	11.4	-3.4	-2.6	3.0	0.1
Birth weight of first child	1.0	1.9	4.4	2.1	1.5	-0.0	-1.0
Peak expiratory flow (PEF)	0.3	0.7	1.7	0.3	0.1	1.0	1.3
Pulse wave reflection index	0.7	0.8	2.6	-0.4	0.8	-1.6	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	0.1	-0.7	0.2	0.2
Loud music exposure frequency	1.2	1.3	3.3	-1.8	-1.3	0.4	-0.0
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	5.8	0.7	-0.7	-2.4	-0.3
Mouth/teeth dental problems: Bleeding gums	2.8	3.6	6.8	-1.8	-2.0	0.6	-2.6
Blood clot in the leg (DVT)	0.3	0.4	1.1	0.5	1.1	-0.2	0.2
Medication: Paracetamol	1.3	2.2	4.8	-2.2	0.8	1.3	-1.2
Headache pain in last month	0.4	0.7	1.0	-0.8	-0.4	-1.0	-0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.0	1.4	0.9	-0.8	-1.1
Glaucoma (self-reported)	0.7	0.8	1.4	-0.5	-1.2	-1.1	-0.1
Gout (self-reported)	1.0	1.4	3.2	-1.5	0.3	1.8	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	0.1	0.8	-0.4	-0.3
Medication: Amlodipine	0.6	0.9	1.6	-0.9	-0.2	1.3	1.1
Medication: Ventolin 100micrograms inhaler	2.7	3.5	6.7	-2.4	-1.4	2.6	-0.1
Birth weight	3.0	6.6	15.7	3.3	4.0	-0.1	-0.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.0	1.0	-0.4	-0.0	-0.6
High blood pressure (siblings)	0.5	0.7	1.3	-1.1	0.3	1.1	0.6
Forced vital capacity (FVC), Best measure	1.2	4.5	8.2	2.1	1.7	2.9	1.6
Body fat percentage	1.6	6.4	11.5	-3.4	-2.8	-0.7	2.5
Leg fat percentage (right)	1.2	4.4	12.1	-3.5	-1.6	-1.1	1.3
Arm fat-free mass (right)	0.7	3.4	7.1	2.7	2.3	-0.3	1.0
Exposure to tobacco smoke outside home	0.7	1.0	3.6	-1.9	0.2	-0.4	-0.0
Comparative body size at age 10	0.3	0.7	1.4	-1.2	-1.1	0.2	0.4
Number of full brothers	2.3	2.9	8.4	-2.9	-1.6	0.7	0.2
Worry too long after embarrassment	2.4	4.0	9.3	-2.1	-3.1	1.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.5	0.7	-0.2	-0.5
Wheeze or whistling in the chest in last year	2.0	3.6	7.3	-2.7	-2.6	0.4	-0.3
Number of children fathered	0.5	0.6	1.6	-0.5	-1.2	-0.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.5	-0.5	-2.1	-0.7	1.3
Age at first live birth	0.3	0.5	1.1	-0.1	-0.8	1.0	0.3
Pulse wave peak to peak time	0.9	1.1	2.5	1.1	0.7	1.6	-0.1
Health satisfaction	0.9	1.2	4.3	-0.4	0.4	-2.1	-0.3
Shortness of breath walking on level ground	0.3	0.3	0.6	0.8	-0.7	0.2	0.2
Qualifications: College or University degree	0.9	2.7	6.0	-0.9	-1.9	-0.6	-2.4
Eye problems/disorders: None of the above	1.1	1.2	1.9	1.2	1.4	1.2	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	0.8	0.0	-0.3	-0.2
Emphysema/chronic bronchitis	0.7	0.8	2.3	0.8	1.5	0.1	-0.3
Medication for pain relief, constipation, heartburn	1.3	2.2	7.3	2.7	1.1	0.5	-0.3
Neck or shoulder pain in last month	0.6	0.8	1.5	1.2	0.9	0.9	-0.4
Medication: Blood pressure	1.7	3.0	6.3	-2.5	-2.2	0.7	0.7
Angina (self-reported)	0.8	1.1	3.0	0.6	0.9	0.4	1.7
Migraine (self-reported)	0.4	0.5	1.2	-0.0	1.1	-1.0	-0.0
Medication: Ibuprofen	0.6	0.7	1.3	-1.2	-0.4	1.0	0.2
Medication: Allopurinol	0.8	1.0	2.0	-1.4	-0.2	1.3	0.5
Medication: Omeprazole	1.0	1.2	2.8	-1.1	0.6	-0.6	1.7
Medication: Seretide 50 evohaler	0.7	0.8	1.6	-1.1	-1.3	0.2	-0.6
Mean time to correctly identify matches	0.3	0.6	1.4	-0.4	1.2	-1.0	-0.2
Heart disease (mother)	1.9	2.3	4.8	0.1	0.3	2.1	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.8	-0.9	-0.9	-0.8	-0.4
Whole body fat mass	0.8	3.1	6.0	-1.8	-1.7	-0.6	2.5
Leg fat mass (right)	0.5	1.8	3.0	-1.7	-0.9	-0.8	1.7
Arm predicted mass (right)	0.7	3.5	6.5	2.5	2.5	-0.3	1.1
Pulse rate, automated reading	1.0	3.1	9.7	-3.1	-1.6	-0.2	0.5
Alcohol intake frequency.	0.3	0.8	1.3	0.9	1.2	0.6	-0.8
Comparative height size at age 10	0.1	0.6	1.8	1.4	-0.4	0.3	0.4
Number of full sisters	0.6	0.8	1.5	0.4	1.2	-0.7	-0.9
Suffer from ‘nerves’	2.2	3.4	5.1	-2.0	-1.7	-1.4	-2.2
Overall health rating	0.6	1.3	4.2	-2.0	-0.4	-0.2	-1.0
Chest pain or discomfort	1.6	2.3	6.0	-1.5	-0.9	2.4	0.5
Had major operations	0.3	0.4	1.3	-0.2	-0.3	-1.1	-0.1
Age at last live birth	1.1	1.5	3.7	-0.7	-1.9	1.2	-0.7
Family relationship satisfaction	0.3	0.3	0.6	0.5	-0.1	-0.7	-0.8
Leg pain on walking	0.2	0.3	0.8	0.2	-0.4	-0.9	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.8	-0.8	0.4	2.0	1.1
Commuting to job workplace: Car/motor vehicle	2.1	2.5	5.0	2.2	0.5	1.1	1.8
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	7.8	0.3	-0.8	2.8	0.8
Medication: Aspirin	3.3	4.4	6.8	-2.1	-2.6	-2.5	-0.8
Supplements: Vitamin C	1.0	1.2	2.5	-0.4	-1.3	-0.6	-1.6
Knee pain experienced in last month	0.0	0.0	0.1	0.0	-0.1	-0.2	0.3
Hypertension (Self-reported)	2.7	7.4	18.0	-4.2	-3.1	0.6	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.1	-1.1	-0.5	0.1	0.0
Illnesses of father: Heart disease	0.4	0.6	0.9	-0.2	-0.8	-1.0	0.9
Illnesses of siblings: Diabetes	3.2	3.9	10.9	-3.3	-2.1	0.4	0.1
Smoking status: Previous	2.2	3.3	9.2	-1.5	-3.0	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.9	1.4	1.4	-0.6	0.6
Whole body fat-free mass	0.8	4.6	10.9	3.3	2.5	-0.8	0.7
Leg fat-free mass (right)	0.8	4.0	10.1	3.2	1.7	-1.0	1.4
Arm fat percentage (left)	1.0	3.8	6.4	-2.5	-1.9	-1.1	1.9
Average weekly red wine intake	0.8	1.1	2.2	-1.5	-1.2	-0.7	0.7
Handedness (chirality/laterality): Left-handed	3.4	4.0	9.2	-1.4	-1.5	-1.7	-3.0
Mood swings	0.1	0.2	0.4	-0.5	0.6	0.4	0.1
Loneliness, isolation	2.6	3.6	8.5	-0.8	0.8	-2.1	-2.9
Long-standing illness, disability or infirmity	0.4	0.7	1.5	-1.2	0.5	-0.3	0.9
Ever had bowel cancer screening	0.8	0.9	3.4	-0.6	0.1	-1.8	0.1
Diabetes diagnosed by doctor	4.4	7.2	18.0	-3.2	-4.2	0.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.8	-1.0	-0.6	-2.0	0.9
Friendships satisfaction	1.0	1.2	2.0	-1.4	-1.1	-0.4	-1.2
Qualifications: nursing, teaching	0.8	1.2	3.4	-1.2	-1.8	0.5	0.0
Commuting to job workplace: Walk	0.4	0.4	0.8	-0.5	-0.5	0.7	0.9
Eye problems/disorders: Cataract	0.8	0.9	2.6	0.6	0.3	-0.6	1.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	4.5	0.1	-0.3	-1.9	-2.1
Medication for cholesterol	2.5	3.8	8.3	2.9	1.9	1.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.5	1.2	0.4	-0.2	-0.2
Back pain experienced in last month	0.1	0.2	0.5	-0.0	0.7	-0.3	-0.3
Mineral and other dietary supplements	3.1	4.2	4.8	1.7	2.1	2.2	2.2
Breast cancer (self-reported)	0.3	0.3	0.8	-0.9	0.1	-0.2	-0.8
Asthma (self-reported)	0.6	1.2	3.5	-0.9	-1.9	0.6	0.2
Osteoporosis (self-reported)	0.9	1.1	1.7	0.7	1.3	1.1	1.0
Osteoarthritis (self-reported)	0.2	0.2	0.5	-0.2	-0.7	-0.4	0.4
Medication: Aspirin	2.4	3.1	4.6	-1.8	-2.0	-2.1	-0.9
Medication: Gliclazide	3.2	3.7	8.1	-1.4	-2.8	1.5	1.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	0.2	1.2	-0.1	0.5
Smoking status: Current	0.3	0.4	1.1	0.5	0.6	1.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.4	1.2	0.5	0.5	0.6
Whole body water mass	0.8	4.7	11.4	3.4	2.5	-0.8	0.7
Leg predicted mass (right)	0.7	4.0	10.0	3.2	1.7	-1.0	1.4
Arm fat mass (left)	0.4	1.5	3.2	-1.3	-0.7	-0.8	1.8
Number of self-reported non-cancer illnesses	2.2	3.8	8.1	-2.9	-2.3	-1.3	0.6
Average weekly champagne plus white wine intake	0.2	0.3	1.0	1.0	-0.0	-0.3	0.1
Miserableness	0.4	0.6	1.7	-1.3	-0.5	0.8	0.0
Guilty feelings	0.8	1.2	2.4	-1.2	-1.5	-0.1	1.0
Wears glasses or contact lenses	0.5	0.6	2.0	0.2	-0.2	-1.4	0.3
Ever taken oral contraceptive pill	0.4	0.4	0.9	-0.5	-0.8	-0.9	-0.1
Hearing aid user	0.7	0.7	2.0	-1.4	0.3	-0.4	0.8
Mother’s age at death	1.0	1.2	3.1	0.4	-1.8	1.1	0.8
Financial situation satisfaction	1.7	2.1	6.0	-2.4	-1.4	0.1	0.9
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.1	-1.0	-0.5	-0.7	0.2
Commuting to job workplace: Public transport	1.9	2.3	5.8	-1.4	-0.7	-2.4	-0.8
Eye problems/disorders: Glaucoma	1.5	1.7	3.5	0.0	-1.8	-0.4	1.9
Medication: Blood pressure	2.5	4.8	12.4	-3.5	-1.9	-1.3	1.2
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.8	1.2	1.7	0.6	-0.7
Supplements: Fish oil (including cod liver oil)	3.1	4.0	4.9	-1.4	-2.2	-2.2	-2.1
High cholesterol (Self-reported)	0.6	1.1	4.0	-0.4	-0.3	-0.5	2.0
Medication: Bendroflumethiazide	1.1	1.7	3.1	-1.3	-1.8	0.4	1.3
Medication: Paracetamol	1.1	1.7	4.3	-2.1	0.7	1.2	-0.9
Medication: Lisinopril	0.8	1.1	2.8	-1.1	-1.7	0.4	0.4
Medication: Atorvastatin	0.4	0.5	0.9	0.2	0.6	-0.8	-0.9
Illnesses of father: High blood pressure	0.8	1.0	2.5	0.2	-0.5	1.6	-1.0
Alcohol drinker status: Never	0.2	0.2	0.5	0.5	0.3	-0.7	-0.4
Ever smoked	1.6	2.7	9.7	-0.7	-3.1	0.3	0.7
Basal metabolic rate	0.6	3.1	7.0	2.6	1.9	-0.9	1.0
Leg fat percentage (left)	1.1	4.0	8.6	-2.9	-1.5	-1.0	2.0
Arm fat-free mass (left)	0.5	2.7	5.8	2.4	2.1	-0.4	0.5
Number of operations (self-reported)	0.1	0.2	0.6	-0.1	-0.2	-0.8	-0.3
Average weekly beer plus cider intake	0.7	1.0	2.2	-1.0	1.5	-0.6	-0.7
Irritability	0.7	1.1	2.5	-0.7	-1.6	-0.9	0.9
Risk taking	0.4	0.6	1.1	0.7	0.9	1.0	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	0.6	-0.2	0.3	0.8
Fractured/broken bones in last 5 years	2.0	2.5	5.2	-2.0	-2.3	1.0	-0.4
Age started oral contraceptive pill	1.2	1.5	3.6	-1.4	-1.9	0.7	0.5
Diastolic blood pressure, automated reading	1.0	3.2	7.5	-2.7	-1.6	1.0	1.3
Ever depressed for a whole week	4.2	5.2	13.2	-2.6	-3.6	0.8	-0.1
Unable to work because of sickness or disability	0.6	0.8	2.3	0.5	1.5	0.5	-0.5
Commuting to job workplace: Cycle	0.6	0.7	1.3	0.9	1.1	-0.1	0.9
Myopia	0.5	0.7	1.4	-1.2	-1.1	0.3	-0.2
Vascular/heart problems diagnosed by doctor	2.8	7.8	20.2	4.5	3.2	-0.1	-0.9
Cholesterol lowering medication	1.5	2.3	5.2	-2.3	-1.3	-1.1	0.9
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	6.6	-0.5	0.3	-0.7	2.6
Pain experienced in last month	0.3	0.5	1.4	1.2	-0.1	0.4	0.4
Supplements: Calcium	0.6	0.6	1.4	-0.2	-1.2	-0.4	-1.0
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	0.6	-0.6	0.2	0.7
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.1	-1.4	-0.4	-1.0	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.1	0.7	-0.7	-0.1
Heart disease (siblings)	0.6	0.8	1.9	-1.4	-0.3	-0.2	1.0
Alcohol drinker status: Previous	0.8	1.0	1.3	-1.2	0.5	-1.0	-1.1
Pack years of smoking	0.6	0.9	2.0	-0.6	-1.4	0.9	0.7
Impedance of whole body	1.6	8.3	16.9	-3.7	-4.1	1.7	-0.2
Leg fat mass (left)	0.5	1.9	4.2	-1.5	-0.8	-0.8	2.0
Arm predicted mass (left)	0.5	2.7	6.0	2.4	2.1	-0.6	0.6