Best TWAS P=3.24e-15 · Best GWAS P=2.51e-17 conditioned to 0.000474
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | SUPT3H | 0.37 | 0.14 | lasso | 11 | 0.18 | 1.3e-05 | -3.6 | -6.2 | 4.7e-10 | 0.00 | 0.18 | 0.68 | TRUE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | SUPT3H | 0.27 | 0.01 | lasso | 3 | 0.00 | 2.7e-01 | 5.3 | 5.2 | 2.3e-07 | -0.04 | 0.07 | 0.51 | FALSE |
| 3 | GTEx | Muscle Skeletal | CLIC5 | 0.13 | 0.08 | lasso | 4 | 0.06 | 7.8e-07 | -6.3 | 6.5 | 7.9e-11 | -0.61 | 0.59 | 0.39 | FALSE |
| 4 | GTEx | Testis | CLIC5 | 0.40 | 0.17 | lasso | 7 | 0.20 | 2.0e-09 | -8.1 | -7.9 | 3.2e-15 | 0.83 | 0.07 | 0.93 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CLIC5 | 0.06 | 0.00 | blup | 182 | 0.02 | 1.0e-03 | -7.9 | 5.4 | 6.5e-08 | -0.54 | 0.18 | 0.57 | FALSE |