Hub : Genes

CLIC5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1660 0.0360 4.9e-12 0.083 0.113 0.095 0.105 0.088 2.6e-10 1.3e-13 1.3e-11 8.9e-13 7.6e-11
2 GTEx Muscle Skeletal 0.1336 0.0387 7.0e-05 0.077 NA 0.051 NA 0.063 5.7e-08 NA 9.3e-06 NA 7.8e-07
3 GTEx Nerve Tibial 0.1729 0.0596 1.4e-03 0.041 NA 0.096 NA 0.090 6.3e-04 NA 2.6e-07 NA 5.9e-07
4 GTEx Testis 0.3980 0.0740 4.9e-08 0.168 NA 0.199 NA 0.204 6.7e-08 NA 3.2e-09 NA 2.0e-09
5 GTEx Thyroid 0.0840 0.0310 4.0e-03 0.062 NA 0.063 NA 0.060 1.7e-05 NA 1.3e-05 NA 2.3e-05
6 YFS Blood 0.1433 0.0232 0.0e+00 0.105 0.092 0.100 0.108 0.109 1.3e-32 1.2e-28 4.2e-31 2.1e-33 7.3e-34
7 TCGA Glioblastoma Multiforme 0.2680 0.1050 3.6e-03 -0.009 0.082 0.010 NA -0.007 8.8e-01 1.8e-03 1.5e-01 NA 6.2e-01
8 TCGA Brain Lower Grade Glioma 0.0648 0.0223 3.0e-05 0.002 0.023 0.022 NA 0.008 2.0e-01 1.1e-03 1.2e-03 NA 3.8e-02
9 TCGA Prostate Adenocarcinoma 0.0737 0.0336 9.1e-03 -0.001 0.010 0.000 NA -0.003 4.0e-01 2.8e-02 3.2e-01 NA 9.7e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.8 1.3 4.8 0.5 -1.6 -1.1 2.2 0.1 0.2 -1.3 -0.9 -0.7
Bipolar Disorder or Schizophrenia 1.3 3.3 8.3 -1.8 -1.2 -1.8 1.3 -1.7 -1.4 -2.9 -2.2 1.3
Depressed Affect (Nagel 2018) 0.5 1.0 2.2 -1.4 -1.5 1.0 0.1 0.7 1.2 0.5 -0.4 -1.2
Depression (Nagel 2018) 1.3 1.9 6.7 -2.6 -2.1 -0.8 1.1 -0.9 0.3 -1.1 -1.4 -0.2
Intelligence (Savage-Jansen 2018) 1.0 3.0 7.6 2.7 1.2 0.3 -1.1 1.4 0.9 2.8 2.6 -0.4
Neuroticism (Nagel 2018) 0.6 1.3 3.0 -1.7 -0.7 1.2 -1.3 1.6 1.2 1.1 0.1 -0.6
Schizophrenia (2018) 1.9 3.9 7.7 -2.8 -0.2 -1.5 -0.0 -2.3 -2.0 -2.6 -2.1 2.2
Schizophrenia vs Biploar Disorder 0.8 1.1 5.0 -1.1 0.1 -0.6 -0.4 -0.7 -0.9 -1.0 -0.9 2.2
Worry (Nagel 2018) 0.7 1.4 9.1 -3.0 -0.4 0.4 -1.1 0.1 0.2 -0.4 -0.9 0.9
Alzheimer’s Disease (in mother) 1.2 1.4 4.5 0.6 0.4 -0.1 -0.5 2.1 1.9 1.6 0.7 0.6
Alzheimer’s Disease (in father) 1.3 1.4 3.8 0.5 -1.9 0.5 1.6 1.2 1.4 -0.8 -0.4 -1.2
Alzheimer’s Disease (including proxy) 1.5 2.1 9.1 0.8 -0.6 0.5 -0.1 3.0 2.6 1.2 0.6 -0.1
Crohns Disease (2017) 0.6 1.3 3.7 -0.7 -1.9 -0.4 0.9 -1.5 -0.1 -1.1 -1.3 1.1
Irritable Bowel Disease (IBD) 0.1 0.3 1.9 0.2 -1.4 -0.5 0.1 -0.7 0.1 0.1 -0.3 0.3
Ulcerative Colitis (UC) 0.1 0.3 0.7 0.8 -0.4 -0.3 -0.3 0.5 0.2 0.9 0.6 -0.3
Major Depression (MDD) 1.8 2.2 6.1 -2.5 -1.1 -0.4 0.4 -1.7 0.4 -1.4 -2.2 -1.6
Reaction Time 0.6 1.2 4.2 -1.2 -2.0 -0.1 0.8 -1.0 0.9 0.1 -1.2 0.9
Verbal and Numeric Reasoning (VNR) 1.8 4.3 13.4 2.8 1.8 0.8 -1.3 2.2 -0.1 2.6 3.7 -0.8
Breast Cancer 1.2 3.0 6.5 -2.0 -1.4 -2.5 1.8 -2.3 -0.4 -1.4 -1.5 1.0
Ovarian Cancer 1.3 1.8 4.6 -0.7 -1.8 -0.7 2.1 -1.4 -0.7 -1.0 -1.5 1.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.8 2.7 10.8 3.3 1.1 1.2 -0.8 2.0 0.1 1.9 1.2 -0.9
Bipolar Disorder (2011) 4.0 3.9 10.5 -2.5 -1.1 -2.0 1.8 -1.4 -0.5 -3.2 -2.7 -0.1
Body Mass Index (BMI) (2010) 1.1 1.5 4.8 -0.8 -2.2 -0.4 1.2 -1.3 0.9 -0.8 -1.5 -1.2
Coronary Artery Disease (CAD) 0.3 0.3 0.8 -0.9 0.3 0.5 -0.2 0.4 0.9 -0.2 -0.8 0.0
Crohns Disease (2012) 0.6 1.0 3.8 0.0 -2.0 0.5 0.6 -1.0 0.4 -1.3 -1.4 -0.3
Mean Putamen Volume 0.6 0.7 2.0 -1.4 -0.1 -0.2 0.2 -1.1 0.9 -0.2 -0.8 1.3
Fasting Glucose 0.9 1.1 2.1 -1.1 0.7 1.0 -1.4 -0.7 -1.4 -1.0 0.1 1.4
HbA1C 0.7 0.8 2.8 1.2 -0.4 0.2 1.1 -0.4 -0.3 0.5 1.0 1.7
HDL Cholesterol 0.5 0.8 4.7 0.8 0.5 0.4 -0.9 -0.3 0.8 0.3 0.5 -2.2
LDL Cholesterol 0.3 0.5 1.5 -1.2 0.8 -0.7 -1.1 0.1 -0.4 0.0 0.2 0.3
Lupus 0.9 1.3 8.2 -0.2 -0.2 0.4 -1.1 -0.8 2.9 1.0 -0.4 -0.3
Neuroticism (2016) 1.0 1.5 3.2 0.3 -1.6 1.3 -1.4 1.8 1.3 0.7 0.1 -1.3
Primary Biliary Cirrhosis 0.5 0.7 2.5 -0.6 -1.6 -0.3 -0.1 -1.3 0.2 -0.2 -0.5 1.2
Rheumatoid Arthritis 0.5 0.8 1.7 -0.8 0.1 1.3 -0.5 -0.8 1.0 -1.0 -1.1 0.3
Schizophrenia (2014) 1.0 2.1 5.8 -2.4 -0.3 -0.8 -0.5 -1.5 -1.0 -1.9 -1.5 1.9
Triglycerides 0.1 0.2 0.6 0.6 0.1 -0.0 -0.4 0.7 0.2 0.8 -0.0 0.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.5 -0.9 -0.8 -0.3 -0.7 -1.0 -1.6 -0.3 -0.7 0.1
Ulcerative Colitis 0.1 0.2 0.8 -0.5 -0.3 -0.2 -0.3 0.2 0.5 -0.1 -0.5 0.9
Blood Eosinophil Count 0.4 3.3 10.3 -1.1 -1.1 0.4 3.2 -1.7 -1.8 -1.8 -1.4 2.3
Blood Platelet Count 0.0 0.5 1.1 -0.2 0.5 0.4 -0.9 1.1 0.6 0.7 0.2 1.0
Blood Red Count 0.4 3.5 15.8 4.0 0.2 0.5 1.4 1.2 0.3 2.2 2.7 0.5
Blood White Count 0.5 3.5 6.1 -1.4 -0.4 -2.5 2.4 -2.4 -1.1 -1.7 -1.6 2.4
Heel T-Score 1.7 13.2 31.1 3.1 4.5 -1.3 -5.6 -0.6 4.6 4.0 3.2 2.8
BMI 0.4 2.3 5.6 2.4 0.9 0.1 1.2 0.9 1.4 0.8 2.2 2.1
Height 0.2 2.9 17.1 -0.8 -1.3 4.1 -0.1 2.2 -0.7 -0.0 -0.7 -1.0
Waist Hip Ratio (WHR) 1.3 5.7 13.9 -2.3 -2.6 -2.5 3.7 -1.5 -2.3 -2.1 -2.8 0.0
Systolic Blood Pressure 0.7 3.6 8.4 -2.9 -2.0 -1.5 1.3 -0.7 -1.6 -2.9 -2.1 0.7
Smoking Status 0.4 0.9 3.4 0.8 1.1 -1.8 0.2 -1.0 -1.0 0.6 0.1 0.8
Allergy or Eczema 0.9 2.3 11.2 0.3 -1.1 -0.4 3.3 -0.8 -2.0 -1.6 -0.8 0.8
Cardiovascular Disease 0.5 1.8 6.0 -2.5 -1.2 -0.8 0.5 -1.0 -0.4 -2.0 -0.9 1.1
Hypothyroidism (self reported) 1.3 3.0 13.2 1.1 -1.6 1.4 -1.4 2.0 3.6 0.9 0.2 1.3
Respiratory disease 0.4 0.8 2.0 -0.8 -1.4 0.5 1.2 0.6 -1.2 -0.2 -0.4 -0.9
Type 2 Diabetes (T2D) (2018) 0.6 1.1 6.2 2.5 -0.5 -0.6 0.7 1.2 0.8 0.4 0.1 0.8
Lung FEV1/FVC ratio 1.8 8.9 25.0 2.2 2.4 5.0 -2.0 3.6 3.6 2.8 2.7 -0.6
Lung FVC 0.7 3.5 17.2 -2.2 1.6 -0.7 -4.1 -0.5 1.1 0.7 1.2 1.5
Neuroticism 0.7 1.7 4.8 -0.5 -0.9 1.5 -1.1 2.2 1.0 1.7 1.0 -1.2
Chronotype (morning person) 2.4 5.4 13.7 -0.9 3.2 2.3 -3.7 2.9 0.4 1.9 2.1 1.6
Hair Pigment 0.7 20.9 62.1 2.8 6.5 2.7 -7.9 2.3 3.8 4.2 5.4 1.2
Tanning 0.1 1.2 3.7 -0.1 -1.9 -0.3 1.9 0.6 0.9 -0.9 -0.5 -1.1
Hand grip strength (left) 0.2 0.4 0.9 -0.5 0.8 -0.9 -0.5 0.3 -0.5 -0.9 0.4 0.7
Number of treatments/medications taken 0.4 0.7 1.8 -1.4 -0.7 1.1 -0.2 0.8 -0.7 -0.3 -0.2 1.1
Average weekly spirits intake 0.4 0.5 2.4 0.2 0.3 -1.6 -0.0 -0.5 0.0 0.2 0.8 1.1
Sensitivity / hurt feelings 0.8 1.3 3.5 0.6 -0.2 0.8 -1.4 1.9 1.0 1.4 1.2 0.9
Frequency of depressed mood in last 2 weeks 1.1 1.5 6.5 -2.6 -1.9 0.1 0.5 0.1 0.5 -1.0 -0.9 0.9
Hearing difficulty/problems: Yes 1.4 2.2 8.1 -0.9 1.5 1.9 -2.8 0.8 1.4 1.3 0.6 -0.7
Relative age of first facial hair 0.1 0.2 0.5 -0.1 0.5 0.7 -0.7 0.5 -0.2 0.2 0.6 0.3
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 3.4 -0.3 0.9 1.9 -1.2 0.5 1.0 0.5 1.0 -0.8
Ever used hormone-replacement therapy (HRT) 0.9 1.2 4.1 -0.5 -1.3 2.0 -0.9 0.5 1.4 1.0 -0.4 -0.7
Ever had hysterectomy (womb removed) 0.6 0.7 3.3 0.1 -0.3 -1.3 -0.1 0.1 1.1 1.8 -0.4 -0.0
Systolic blood pressure, automated reading 0.3 0.8 2.6 -1.2 -0.9 0.2 0.7 1.0 -1.6 -0.6 -0.7 -0.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 2.0 1.4 0.3 0.7 -0.7 0.8 1.1 0.6 0.7 -0.1
Angina 0.4 0.5 1.9 -0.3 -0.7 1.0 1.4 0.6 0.8 0.2 0.2 0.6
Medication for hormone replacement therapy 0.2 0.2 0.4 -0.7 -0.4 0.3 0.6 0.3 -0.5 -0.5 -0.3 0.6
Vitamin and mineral supplements 0.9 1.2 5.2 1.6 -0.1 2.3 0.5 0.3 0.2 0.4 0.2 -1.5
Supplements: Zinc 1.1 1.2 3.2 -1.8 0.5 -0.8 -1.6 -1.5 -1.0 -0.3 -0.8 0.7
Medication: Co-codamol 0.5 0.6 4.2 -0.7 0.0 -0.3 -0.3 0.1 2.0 -0.1 -0.2 0.2
Medication: Metformin 0.7 1.0 2.7 -0.2 -1.1 -1.2 0.5 -1.0 -0.6 -0.8 -1.3 1.7
Diabetes (father) 0.3 0.4 1.5 -0.6 0.0 -0.7 -1.1 0.1 1.2 0.1 -0.1 0.3
Diabetes (mother) 0.4 0.4 1.4 -0.5 -0.1 -1.2 -0.2 -1.0 -0.8 -0.6 0.0 0.6
Severe depression (siblings) 0.6 0.7 2.2 1.5 -0.4 -0.2 1.5 0.6 -0.9 0.5 0.2 -0.5
Pack years adult smoking proportion 1.3 2.0 6.4 0.1 0.8 -1.9 -0.6 -2.5 0.2 -0.8 0.4 2.5
Impedance of leg (right) 0.4 1.9 5.0 -1.6 -0.3 -1.1 -0.5 -1.0 -1.9 -1.0 -1.6 -2.2
Leg fat-free mass (left) 0.4 2.2 7.1 1.4 -0.5 2.7 1.1 2.1 1.6 0.7 1.2 0.2
Trunk fat percentage 0.2 1.0 3.5 0.0 -1.1 0.7 1.7 0.4 0.3 -1.9 0.1 0.7
Hand grip strength (right) 0.1 0.3 0.9 -0.5 0.7 -0.4 -0.1 -0.0 0.4 -0.9 -0.2 0.7
Townsend deprivation index at recruitment 0.3 0.4 1.1 -1.0 -0.7 -0.2 0.8 0.0 -1.1 -0.2 -0.3 0.6
Current tobacco smoking 0.7 1.1 3.2 -0.0 1.1 -1.5 0.1 -0.9 -1.5 0.1 0.3 1.8
Average weekly fortified wine intake 1.4 1.6 5.9 0.1 0.9 0.4 -0.8 1.3 0.8 0.4 2.1 2.4
Maternal smoking around birth 0.3 0.4 1.0 -1.0 -0.2 -1.0 0.3 -0.5 -0.5 -1.0 -0.6 -0.3
Fed-up feelings 1.2 2.2 7.8 -1.4 -2.8 0.0 1.5 -0.4 0.5 -1.4 -1.7 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.0 -1.4 -1.1 -0.9 0.9 -0.2 -0.3 -0.7 -0.6 0.8
Relative age voice broke 1.0 1.6 6.8 -0.7 1.0 1.0 -1.2 1.5 0.3 0.2 0.9 2.6
Taking other prescription medications 0.6 1.0 3.6 -0.9 -1.9 0.9 1.1 0.1 0.1 -0.5 -1.3 -0.7
Age when periods started (menarche) 0.9 2.1 5.4 -2.1 -1.0 -0.5 0.9 -1.7 -1.2 -1.6 -2.3 -0.3
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.3 -0.3 -0.8 0.6 -1.0 0.1 0.5 0.5 1.0 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.8 0.5 1.7 -0.1 -1.2 0.5 0.3 1.2 0.6 1.1
Tinnitus: Yes, but not now, but have in the past 2.8 2.9 7.1 -2.4 -1.1 -1.6 1.8 -0.4 -1.0 -2.7 -2.1 0.8
Qualifications: CSEs or equivalent 1.3 1.7 5.6 -2.4 -0.3 -0.5 -0.9 -1.6 1.2 -1.6 -0.5 1.3
Serious illness, injury or assault to yourself 0.3 0.4 2.2 -0.6 -0.1 1.5 0.1 -0.2 0.1 0.6 0.4 0.1
High blood pressure 0.3 0.9 4.6 -2.1 -0.5 -0.8 -0.1 -0.8 -0.5 -1.4 -0.2 -0.2
Hayfever, allergic rhinitis or eczema 1.1 2.5 9.9 -0.6 -1.6 -0.6 3.1 -1.1 -1.6 -1.9 -0.9 0.9
Multivitamins +/- minerals 0.5 0.6 1.7 -1.3 -0.3 -1.3 0.0 -0.0 0.7 -0.5 -0.5 0.9
Stomach or abdominal pain in last month 0.9 1.1 6.4 0.1 -0.9 2.5 -0.6 -0.2 1.4 0.1 0.1 0.0
Supplements: Glucosamine 0.7 0.9 2.2 0.4 -1.1 1.4 0.3 1.5 0.4 -0.1 0.7 1.5
Diverticular disease/diverticulitis (self-reported) 1.1 1.2 3.8 -2.0 -0.5 -0.4 0.0 -0.4 0.8 -1.0 -1.7 -1.5
Medication: Atenolol 3.1 3.8 8.8 -1.7 -1.1 -2.5 1.6 -2.7 -1.0 -3.0 -1.8 1.2
Medication: Levothyroxine sodium 1.7 2.9 12.7 1.4 -0.6 1.1 -1.6 0.8 3.6 1.6 0.5 2.0
Sitting height 0.5 3.2 12.9 -0.5 0.9 3.6 -1.8 2.0 2.0 1.5 1.1 -0.5
Chronic bronchitis/emphysema (father) 0.7 0.8 2.9 -0.3 -0.8 -0.1 1.3 -0.9 -1.7 -0.3 -0.7 -0.1
High blood pressure (mother) 1.5 2.1 6.0 -2.4 -1.8 -1.1 0.8 -0.6 -1.7 -1.2 -1.4 -1.0
Body mass index (BMI) 0.3 1.1 2.7 1.1 -0.4 0.8 1.1 0.8 1.1 -0.3 1.3 1.6
Impedance of leg (left) 0.4 1.9 4.0 -1.7 0.3 -1.0 -0.9 -0.9 -1.9 -1.1 -1.6 -2.0
Leg predicted mass (left) 0.4 2.2 7.1 1.4 -0.5 2.7 1.1 2.1 1.7 0.7 1.2 0.2
Trunk fat mass 0.2 0.9 2.9 0.3 -1.0 1.3 1.7 0.8 0.6 -1.3 0.3 0.3
Waist circumference 0.3 0.9 4.5 0.3 -0.7 0.2 2.1 0.3 -0.3 -1.2 0.6 1.2
Number of incorrect matches in round 0.8 1.3 3.3 -1.5 0.7 -0.4 -1.8 -1.3 0.8 0.0 -0.2 1.7
Past tobacco smoking 0.4 0.8 2.2 -1.2 -0.5 -0.3 0.1 -1.5 0.4 -1.2 -0.9 0.9
Alcohol usually taken with meals 2.1 3.5 8.1 1.5 2.9 2.3 -2.0 0.7 -0.0 1.7 2.0 1.9
Nervous feelings 1.3 2.4 9.2 -3.0 -1.8 -0.2 1.1 0.1 -0.2 -1.6 -1.8 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.3 -1.1 -0.9 1.5 -0.6 -0.4 0.8 0.1 -0.8 -1.0
Hearing difficulty/problems with background noise 1.2 2.0 7.9 -0.7 1.8 0.7 -2.8 0.8 0.8 1.4 0.8 -1.4
Hair/balding pattern: Pattern 2 2.0 2.5 6.2 1.0 1.5 2.0 -1.4 2.4 -0.5 0.7 2.5 -0.8
Had menopause 0.5 0.7 1.7 0.6 -0.2 0.5 -0.8 1.2 1.3 0.3 -0.3 -1.3
Had other major operations 1.7 2.1 4.8 0.7 2.0 1.4 -0.8 1.1 0.3 1.5 1.8 2.2
Forced vital capacity (FVC) 0.3 1.1 5.0 -1.2 0.4 0.7 -2.2 0.5 0.4 1.0 0.5 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.3 1.2 1.1 -0.0 -1.2 0.0 -0.1 1.5 0.7 1.5
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 3.5 0.7 0.3 -0.3 0.9 -0.3 -1.9 0.1 -0.5 -0.3
Qualifications: None of the above 0.4 0.8 2.0 -1.4 -1.2 -0.1 -0.2 0.0 -1.0 -0.7 -1.4 -0.2
Financial difficulties in last 2 years 0.3 0.4 1.6 -0.9 0.1 -0.1 -0.8 0.4 1.3 0.1 -0.3 0.6
Mouth/teeth dental problems 2.7 4.1 16.8 2.7 4.1 0.9 -1.8 0.6 -1.2 1.4 2.3 0.2
Heart attack 0.5 0.6 1.8 -0.4 1.2 0.5 -1.3 0.5 1.3 -0.3 0.3 -0.0
Allergy 0.8 1.9 8.5 0.6 1.6 0.4 -2.9 0.2 1.8 1.4 0.8 -0.2
Pain all over the body in last month 1.0 1.1 2.3 -1.5 -1.3 0.7 1.2 -0.9 -0.2 -0.6 -1.4 -0.7
Diabetes (self-reported) 0.7 1.1 5.6 2.4 0.3 -0.9 0.1 0.3 -0.2 0.8 0.6 1.3
Hayfever/allergic rhinitis (self-reported) 2.4 3.2 7.9 -1.8 -1.9 0.6 2.4 -1.4 -1.5 -2.8 -2.0 0.5
Medication: Ramipril 0.6 0.8 3.5 -1.9 -0.4 -1.0 0.4 -0.4 0.2 -1.0 -0.9 -0.3
Medication: Simvastatin 0.5 0.7 1.7 -1.3 -0.2 -1.0 0.1 0.1 0.1 0.9 -1.3 0.8
Fluid intelligence score 2.9 6.1 11.7 2.7 2.3 2.5 -2.1 3.1 1.3 2.9 3.4 -0.8
Illnesses of siblings 2.3 3.2 12.7 1.9 3.6 -0.5 -1.9 0.8 -0.9 1.4 2.0 1.1
Neuroticism score 0.3 0.7 1.7 -0.6 -1.3 1.2 -0.5 1.2 0.6 0.5 0.4 -0.6
Weight 0.3 1.5 4.6 0.9 -0.7 2.1 1.1 1.6 1.3 -0.0 1.1 0.8
Impedance of arm (right) 0.4 1.7 4.1 -1.0 -1.5 -0.9 1.3 -1.2 -1.3 -2.0 -1.4 -0.9
Arm fat percentage (right) 0.4 1.4 5.8 0.5 -1.2 -0.0 2.4 -0.2 0.1 -1.9 0.3 1.3
Trunk fat-free mass 0.2 0.9 4.3 0.7 -0.1 2.1 0.6 1.3 0.7 0.8 0.5 -0.4
Hip circumference 0.5 2.3 4.5 1.3 -0.4 2.1 1.0 1.7 2.1 -0.5 1.4 2.0
Time employed in main current job 1.1 1.3 4.8 -1.1 1.1 -0.6 -0.2 -0.6 -2.2 -1.1 -0.1 1.6
Alcohol intake versus 10 years previously 0.2 0.3 1.1 -0.0 -1.1 -0.6 0.7 -0.4 0.5 0.3 0.1 0.0
Father’s age at death 0.2 0.3 1.4 0.3 0.2 -1.2 0.3 0.5 0.2 0.5 0.5 0.2
Worrier / anxious feelings 0.7 1.4 4.1 -0.7 0.5 1.5 -2.0 2.0 -0.0 1.2 0.2 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 4.8 -1.1 -2.2 0.5 1.1 0.4 1.4 0.3 -0.6 1.1
Falls in the last year 2.5 3.4 8.4 1.2 2.6 1.2 -1.9 1.1 -0.3 1.7 2.2 2.9
Hair/balding pattern: Pattern 3 1.5 2.2 5.0 -0.7 -1.0 -2.1 1.7 -1.3 -2.2 -1.3 -0.7 1.2
Number of live births 0.6 0.8 3.4 0.6 -0.5 0.5 1.0 0.9 -1.8 -0.7 0.0 0.8
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 8.1 -0.3 0.8 2.9 -2.5 2.0 1.7 2.2 1.4 -1.2
Pulse rate 1.1 1.9 5.5 -1.8 -0.8 -0.8 -0.6 -2.3 0.6 -1.9 -1.6 -0.6
Happiness 1.0 1.3 3.8 -1.4 -0.7 1.3 0.9 0.8 0.6 -0.6 -1.1 -1.9
Noisy workplace 0.8 1.0 4.2 -0.0 -0.3 -1.6 -0.5 -2.0 -1.4 -0.1 -0.1 0.7
Qualifications: A levels/AS levels or equivalent 1.1 2.5 12.5 3.5 1.1 0.9 -0.6 0.9 0.2 1.6 1.9 -0.7
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 4.1 -1.0 -0.3 2.0 -0.8 1.6 1.0 0.2 1.3 0.2
Mouth/teeth dental problems: Dentures 1.0 1.6 4.5 -2.1 -0.8 -1.0 -0.0 -0.8 0.5 -1.8 -1.4 1.6
Asthma 0.6 1.2 3.9 0.5 -1.5 0.4 2.0 0.6 -1.2 -0.4 -0.5 -1.3
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 1.4 0.4 -0.5 -0.5 0.6 0.1 -0.3 -0.6 1.2 0.5
Medication: Cholesterol lowering 0.7 1.0 2.4 -0.9 -1.1 -1.6 0.8 -0.7 0.4 -1.0 -0.5 1.5
Depression (self-reported) 0.6 0.7 1.9 -1.4 0.6 0.6 -0.2 0.9 0.6 -1.0 -0.0 1.2
Medication: Lansoprazole 0.8 0.9 2.8 -1.0 -1.7 0.7 1.1 0.7 0.1 -0.5 -1.0 -0.7
Prospective memory result 1.4 1.7 8.3 -1.0 0.0 -1.9 -0.4 -1.4 -0.4 -0.7 0.1 2.9
Lung cancer (father) 0.3 0.3 1.1 0.7 0.4 0.0 0.3 1.0 0.2 0.6 0.5 0.6
Illnesses of mother 1.0 1.3 4.1 2.0 1.3 1.7 -0.6 0.5 0.3 1.2 0.7 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.0 13.0 -0.2 1.8 2.9 -3.6 1.9 2.2 3.0 1.8 -0.7
Pulse wave Arterial Stiffness index 1.1 1.3 2.7 0.8 -1.3 0.1 1.3 -1.7 -1.3 -0.7 -1.0 -1.4
Impedance of arm (left) 0.3 1.3 3.6 -1.0 -1.4 -0.6 0.9 -1.0 -0.9 -1.9 -1.2 -0.6
Arm fat mass (right) 0.3 1.1 3.4 0.7 -0.8 0.9 1.9 0.6 0.6 -1.2 0.7 1.3
Trunk predicted mass 0.2 0.9 4.0 0.6 -0.0 2.0 0.6 1.2 0.8 0.8 0.4 -0.4
Standing height 0.2 2.1 10.6 -0.4 -0.5 3.2 0.1 1.8 0.4 0.5 -0.3 -2.0
Length of working week for main job 1.6 1.8 5.4 2.1 0.0 0.7 -0.2 1.6 0.7 2.3 0.7 -1.3
Exposure to tobacco smoke at home 0.6 0.7 3.6 1.9 0.4 0.2 -0.2 -0.6 -0.7 0.1 1.0 0.5
Breastfed as a baby 0.6 0.7 3.0 -0.3 -1.1 0.6 1.7 -0.3 0.2 -0.9 -0.7 0.6
Tense / ‘highly strung’ 0.9 1.5 5.3 -2.3 -1.3 0.1 0.1 -0.6 0.0 -1.4 -1.4 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.5 -0.1 -0.4 -1.2 0.2 1.6 1.5 0.7 -0.2 -0.5
Hair/balding pattern: Pattern 4 0.7 1.6 8.2 -0.4 -2.9 -0.5 1.3 -0.5 0.8 -1.3 -1.1 -0.3
Birth weight of first child 0.1 0.2 0.6 0.2 -0.1 0.2 0.2 -0.5 0.1 -0.8 -0.6 0.1
Peak expiratory flow (PEF) 1.4 3.2 10.7 0.4 0.9 3.3 -2.6 1.4 1.5 2.1 1.1 -0.6
Pulse wave reflection index 1.6 1.9 5.2 2.2 -1.7 -0.1 1.9 0.3 -0.7 0.0 -0.2 -2.3
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.3 0.4 0.0 0.5 -0.1 -0.7 -0.9 -0.4 1.1 0.1
Loud music exposure frequency 1.0 1.1 3.0 -0.1 -0.6 -0.9 1.3 -1.3 -1.7 -1.1 -0.6 -0.5
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 4.8 1.1 0.3 0.3 0.8 -0.1 -0.4 0.7 0.0 -2.2
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 9.9 -0.2 -3.1 0.3 1.2 1.2 1.2 -0.6 -1.4 -0.5
Blood clot in the leg (DVT) 0.6 0.7 2.6 -0.4 -1.6 0.4 0.5 0.7 1.6 0.1 0.1 -0.6
Medication: Paracetamol 0.8 1.4 6.6 -1.6 0.8 -0.3 -0.6 0.4 0.6 1.3 0.2 2.6
Headache pain in last month 0.8 1.3 5.2 -0.6 -1.1 0.5 0.6 -0.0 1.6 1.2 -0.6 2.3
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 3.6 1.9 1.3 1.9 -0.2 1.4 -0.0 1.7 0.7 -0.6
Glaucoma (self-reported) 2.7 3.2 8.0 2.8 0.1 2.1 0.6 2.3 -0.1 1.6 2.7 -0.7
Gout (self-reported) 1.0 1.3 5.2 0.8 -2.3 -1.0 1.4 -0.9 0.2 -1.4 -0.1 0.3
Hypothyroidism/myxoedema (self-reported) 1.8 3.6 10.8 1.8 -1.0 2.0 -1.6 2.2 3.3 1.7 0.8 1.4
Medication: Amlodipine 0.8 1.1 4.9 -0.8 -0.6 -2.2 -0.6 -1.2 -1.3 -0.7 0.1 0.6
Medication: Ventolin 100micrograms inhaler 0.8 1.0 3.8 -0.7 -0.0 0.3 1.6 0.9 -2.0 -0.1 -0.0 1.1
Birth weight 1.9 4.1 8.2 -2.6 -0.9 -0.8 0.9 -2.7 -2.1 -2.9 -2.7 0.0
Chronic bronchitis/emphysema (mother) 0.8 0.9 3.3 -0.1 0.7 -1.8 0.8 -0.4 -1.7 -0.4 -0.3 0.8
High blood pressure (siblings) 0.7 1.0 3.1 -1.6 -1.8 0.3 0.5 0.0 0.3 -0.8 -1.0 -0.9
Forced vital capacity (FVC), Best measure 0.8 2.8 9.9 -0.7 1.5 1.6 -3.1 1.3 1.1 2.3 1.2 -0.6
Body fat percentage 0.2 0.7 2.4 0.1 -0.9 0.5 1.5 0.3 0.2 -1.6 0.2 0.8
Leg fat percentage (right) 0.1 0.4 1.0 0.3 -0.5 0.2 1.0 0.5 -0.3 -0.6 0.5 1.0
Arm fat-free mass (right) 0.3 1.6 6.2 0.9 0.3 2.5 0.1 1.8 1.6 0.9 0.5 -0.8
Exposure to tobacco smoke outside home 1.4 1.8 8.8 0.1 1.3 -0.2 -1.1 1.1 -0.7 0.4 1.6 3.0
Comparative body size at age 10 0.6 1.8 10.4 3.2 0.6 -0.3 -0.1 -0.3 1.2 0.1 1.9 -0.2
Number of full brothers 0.9 1.1 2.3 -1.5 -0.2 -0.7 -1.2 -1.4 0.8 -0.5 -1.5 0.8
Worry too long after embarrassment 0.6 1.0 2.3 0.3 0.3 1.4 -1.1 1.4 -0.5 0.7 1.5 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.9 -0.4 -0.0 -0.7 0.9 -0.4 -0.2 -1.0 -0.1 0.1
Wheeze or whistling in the chest in last year 1.0 1.8 3.3 0.2 1.8 1.2 -0.2 1.3 -1.6 1.8 1.6 1.4
Number of children fathered 0.2 0.2 1.4 0.3 -0.1 0.3 -0.0 0.2 0.5 0.0 -0.1 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 1.1 0.4 0.5 0.3 -0.2 -0.4 -1.1 -0.5 0.3 0.4
Age at first live birth 0.4 0.7 3.1 0.8 0.2 0.5 1.8 -0.6 -0.8 -0.7 0.2 -0.5
Pulse wave peak to peak time 1.0 1.2 2.7 -0.8 1.3 0.1 -1.2 1.7 1.3 0.7 0.9 1.1
Health satisfaction 1.6 2.1 6.1 -0.9 -2.4 0.7 2.5 0.7 0.6 -1.6 -1.1 0.9
Shortness of breath walking on level ground 0.5 0.6 2.3 0.4 -0.7 1.5 0.7 0.8 1.1 -0.1 0.4 0.4
Qualifications: College or University degree 0.9 2.8 12.7 3.6 0.3 1.2 0.6 1.7 0.4 1.7 1.6 -1.6
Eye problems/disorders: None of the above 0.6 0.7 3.8 -0.8 -0.5 -0.3 -0.3 0.5 0.3 0.5 -1.0 -1.9
Mouth/teeth dental problems: Loose teeth 1.1 1.3 4.0 -1.1 -2.0 -0.4 0.9 -0.9 -0.4 -1.7 -0.1 -1.3
Emphysema/chronic bronchitis 0.3 0.3 1.2 0.2 -0.0 0.4 -0.2 0.5 -1.0 -0.6 0.1 -1.1
Medication for pain relief, constipation, heartburn 0.5 0.8 3.1 1.7 0.3 -0.5 -0.5 -0.1 0.8 0.3 -0.3 -1.8
Neck or shoulder pain in last month 0.4 0.6 1.6 -0.3 -0.9 -0.9 1.2 -0.3 -0.3 0.2 -0.8 1.3
Medication: Blood pressure 0.6 1.1 4.1 -0.7 -0.6 -2.0 -0.0 -1.6 -0.0 -1.4 0.1 0.3
Angina (self-reported) 0.3 0.5 1.3 -0.2 -0.7 0.9 1.1 0.4 1.0 0.2 0.2 0.6
Migraine (self-reported) 1.9 2.3 5.8 -2.2 -2.4 -0.2 2.0 0.0 0.3 -2.3 -0.8 0.6
Medication: Ibuprofen 0.5 0.6 3.4 0.9 0.4 -0.2 -0.4 0.7 0.3 0.4 1.8 0.5
Medication: Allopurinol 0.8 1.1 3.5 1.7 -1.9 -0.4 1.4 0.3 -0.0 -0.8 0.4 -0.4
Medication: Omeprazole 0.8 0.9 3.0 -0.9 0.5 1.7 -1.3 -0.9 0.5 -0.6 0.5 1.0
Medication: Seretide 50 evohaler 0.5 0.6 2.3 0.1 -0.3 -1.5 1.3 -0.2 -0.7 0.4 -0.0 0.4
Mean time to correctly identify matches 0.7 1.3 4.2 -1.7 -2.0 -0.2 0.6 -1.0 0.9 0.0 -1.4 0.6
Heart disease (mother) 1.4 1.7 6.1 -1.0 -1.4 -1.2 1.3 -1.1 2.5 -0.7 -1.1 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.1 -0.1 0.1 0.8 -0.3 0.6 1.1 0.5 0.5 0.4
Whole body fat mass 0.2 0.9 2.5 0.6 -0.7 1.2 1.6 0.8 0.7 -1.0 0.6 0.5
Leg fat mass (right) 0.2 0.8 2.0 0.9 -0.6 1.0 1.4 1.2 0.5 -0.3 0.8 0.7
Arm predicted mass (right) 0.3 1.3 4.8 1.0 0.2 2.2 -0.0 1.5 1.4 0.8 0.5 -1.0
Pulse rate, automated reading 2.1 6.9 21.2 -1.9 -1.6 -3.7 2.0 -4.6 -1.2 -2.4 -3.1 0.1
Alcohol intake frequency. 0.2 0.6 2.1 0.1 -0.9 0.4 1.2 0.2 -0.6 -0.3 0.3 1.5
Comparative height size at age 10 0.5 2.6 8.7 0.5 -1.5 3.0 0.3 1.9 1.1 1.3 -0.7 -2.3
Number of full sisters 1.1 1.3 6.4 -2.5 -0.4 0.2 -1.5 0.4 1.4 -0.7 -0.8 0.3
Suffer from ‘nerves’ 0.6 1.0 5.7 -2.4 -0.7 0.3 -0.8 0.1 0.7 -0.0 -0.8 1.1
Overall health rating 1.0 2.2 4.2 -1.5 -2.0 -0.4 2.0 -1.7 -0.1 -1.5 -2.0 0.2
Chest pain or discomfort 0.8 1.2 3.7 -1.5 -1.3 -0.9 0.4 -1.0 1.9 0.1 -1.1 -0.4
Had major operations 1.2 1.4 3.4 -1.6 -1.0 -0.9 0.6 -1.8 -0.2 -1.2 -1.9 -0.1
Age at last live birth 1.0 1.5 3.2 -0.6 -0.2 -1.4 1.7 -1.5 -1.6 -1.8 -0.6 0.1
Family relationship satisfaction 0.5 0.6 2.0 0.5 0.9 1.3 -0.7 -0.0 1.4 0.0 0.4 -0.7
Leg pain on walking 2.8 3.5 9.1 -1.0 -3.0 -0.8 2.6 -1.7 -0.3 -2.9 -1.7 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.0 -0.7 0.6 -0.8 0.0 0.5 -1.0 0.0 0.8 0.6
Commuting to job workplace: Car/motor vehicle 1.6 1.9 5.3 -0.3 2.3 1.1 -1.6 0.5 -1.4 0.8 1.6 1.5
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 7.1 2.7 0.3 -0.7 0.2 -0.2 -0.3 0.3 0.4 -0.8
Medication: Aspirin 0.7 0.9 6.7 -0.4 0.6 -0.1 -0.6 0.2 0.8 -0.2 0.2 2.6
Supplements: Vitamin C 0.9 1.1 4.0 -1.7 0.4 -1.1 -0.1 -0.2 -2.0 0.4 -0.9 -0.5
Knee pain experienced in last month 1.3 2.0 6.5 -1.0 -2.6 -0.1 2.1 -0.1 0.4 -0.9 -2.1 -0.7
Hypertension (Self-reported) 0.4 1.1 6.1 -2.5 -0.2 -0.9 -0.5 -1.1 -0.4 -1.2 -0.1 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.2 1.2 0.5 -0.0 -1.0 0.5 0.8 1.5 0.5 -1.2
Illnesses of father: Heart disease 0.5 0.7 1.6 -1.3 -0.4 -1.2 0.2 0.9 1.2 0.0 -0.7 -0.5
Illnesses of siblings: Diabetes 0.3 0.3 0.9 -0.4 -0.9 -0.6 0.9 0.0 0.2 0.2 -0.9 -0.0
Smoking status: Previous 0.6 0.9 2.8 0.9 0.5 0.4 -0.2 1.7 -0.5 1.3 0.8 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.8 -1.4 -1.7 0.8 1.5 0.1 -0.1 -0.4 -1.6 0.2
Whole body fat-free mass 0.3 1.5 6.0 1.1 -0.1 2.5 0.7 1.8 1.2 0.9 0.9 -0.2
Leg fat-free mass (right) 0.4 2.3 7.1 1.5 -0.1 2.7 1.0 2.2 1.6 0.7 1.3 0.6
Arm fat percentage (left) 0.3 1.3 4.9 0.6 -1.3 0.1 2.2 -0.1 0.5 -1.7 0.4 1.3
Average weekly red wine intake 2.9 4.3 8.0 2.3 2.3 1.9 -2.6 1.1 0.5 2.7 2.8 0.9
Handedness (chirality/laterality): Left-handed 2.9 3.5 8.2 -1.4 -2.9 -1.2 2.3 -1.0 -2.1 -2.4 -1.4 1.3
Mood swings 0.4 0.8 1.9 -0.8 -1.0 1.4 -0.2 1.0 1.0 0.9 0.5 -0.8
Loneliness, isolation 1.2 1.7 7.8 -2.8 -0.5 -0.2 0.1 -1.6 -0.4 -1.8 -1.1 0.1
Long-standing illness, disability or infirmity 0.3 0.4 1.6 -0.8 -0.5 0.3 0.5 0.0 -0.1 -0.9 0.0 1.3
Ever had bowel cancer screening 0.5 0.6 1.9 1.3 -0.0 -0.7 0.4 -0.8 -0.0 0.2 1.4 0.5
Diabetes diagnosed by doctor 0.2 0.4 1.5 1.2 -0.4 -0.5 0.3 0.4 0.4 0.3 -0.2 1.1
Ever had stillbirth, spontaneous miscarriage or termination 2.8 3.0 7.2 -1.6 -1.4 -2.0 1.6 -2.7 -1.2 -2.0 -1.6 0.7
Friendships satisfaction 0.6 0.7 1.9 -0.6 0.3 -0.8 -0.1 -1.1 0.9 -0.6 -1.0 -1.4
Qualifications: nursing, teaching 0.3 0.4 1.8 1.3 0.4 0.0 -0.2 -0.5 -0.2 1.0 0.5 0.6
Commuting to job workplace: Walk 0.7 0.8 3.8 0.7 -0.7 0.5 0.0 1.0 2.0 -0.2 0.6 -0.7
Eye problems/disorders: Cataract 0.4 0.4 1.1 0.2 0.4 0.9 -0.8 -0.3 1.0 -0.3 -0.1 1.0
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.9 -0.9 -1.4 0.1 -0.1 0.6 1.2 0.6 -0.1 -0.3
Medication for cholesterol 0.5 0.8 2.0 1.4 0.7 -0.9 -0.8 -1.1 1.2 -0.0 0.6 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 2.7 -0.7 -0.3 -0.4 0.1 0.2 -0.7 -0.0 0.2 1.6
Back pain experienced in last month 0.4 0.6 1.6 0.8 0.9 -1.1 -0.0 -0.9 -0.0 0.3 0.3 1.3
Mineral and other dietary supplements 0.3 0.4 2.2 1.5 0.3 0.4 0.1 -0.1 0.3 0.4 0.7 -0.7
Breast cancer (self-reported) 0.4 0.4 1.3 -0.2 0.8 0.6 -0.6 0.9 0.2 0.5 0.4 1.1
Asthma (self-reported) 0.5 1.0 2.6 0.7 -1.4 0.8 1.6 0.8 -0.9 -0.2 -0.2 -1.3
Osteoporosis (self-reported) 0.5 0.6 3.6 -0.7 -0.3 -0.9 0.3 -0.1 -0.5 -1.9 -0.4 0.1
Osteoarthritis (self-reported) 0.9 1.1 4.1 -1.2 -2.0 0.4 1.3 0.7 -0.2 -1.0 -1.1 -0.6
Medication: Aspirin 0.7 0.9 5.7 -0.0 0.5 0.3 -0.9 0.1 1.2 0.0 0.6 2.4
Medication: Gliclazide 0.6 0.7 3.7 1.1 0.6 -1.9 -0.2 -0.5 0.4 0.2 0.8 -0.4
Illnesses of father: None of the above (group 1) 1.6 2.0 6.0 1.4 1.9 1.5 -1.4 -0.1 -0.5 1.0 2.5 0.9
Smoking status: Current 0.5 0.8 2.2 0.1 0.9 -1.5 -0.1 -1.0 -1.2 -0.0 0.2 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 8.2 -1.0 1.5 0.8 -2.9 0.6 0.7 2.3 0.5 -0.5
Whole body water mass 0.3 1.4 6.0 1.0 -0.1 2.5 0.7 1.6 1.1 0.8 0.8 -0.3
Leg predicted mass (right) 0.4 2.2 6.9 1.5 -0.1 2.6 1.1 2.2 1.6 0.6 1.3 0.6
Arm fat mass (left) 0.3 1.2 3.1 0.9 -0.9 1.0 1.8 0.6 1.2 -1.1 0.8 1.2
Number of self-reported non-cancer illnesses 0.5 0.8 2.6 -1.2 -1.3 0.9 0.7 0.3 -0.0 -1.6 -0.4 -0.2
Average weekly champagne plus white wine intake 1.2 1.6 3.4 1.8 1.1 1.7 0.3 1.1 -1.3 1.1 1.1 -1.2
Miserableness 0.8 1.3 4.5 0.6 -0.6 1.0 -0.7 2.1 1.0 1.8 1.0 -0.4
Guilty feelings 2.9 4.4 10.6 1.8 0.7 2.9 -1.2 3.2 0.8 2.7 2.1 -1.7
Wears glasses or contact lenses 1.3 1.5 4.2 -2.0 0.6 -1.1 -0.4 -1.8 -1.4 -0.1 -1.5 0.5
Ever taken oral contraceptive pill 0.4 0.5 2.5 0.8 -0.1 1.6 0.3 0.3 0.6 0.6 -0.3 -0.7
Hearing aid user 1.2 1.4 5.4 -1.0 2.3 0.8 -2.1 0.3 -0.5 0.6 0.3 0.7
Mother’s age at death 0.2 0.3 1.4 1.2 -0.6 -0.2 0.1 -0.7 0.5 -0.2 0.4 0.0
Financial situation satisfaction 1.0 1.2 2.4 -0.8 -0.8 0.7 1.0 -0.8 1.1 -1.5 -1.5 -1.2
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.0 -0.0 0.8 0.3 -0.5 -0.3 -0.8 0.8 -0.7 -1.0
Commuting to job workplace: Public transport 0.4 0.5 1.1 0.5 -0.6 -0.4 1.1 0.5 0.5 -1.0 0.1 -1.0
Eye problems/disorders: Glaucoma 2.4 2.8 6.1 2.4 0.3 1.8 0.2 2.5 0.2 1.8 2.4 -0.7
Medication: Blood pressure 0.6 1.2 5.9 -2.4 -0.6 0.0 0.2 0.2 -1.0 -1.1 -1.0 -1.0
Pain type(s) experienced in last month: Hip pain 1.2 1.5 3.5 0.7 -1.6 -1.8 1.4 -0.5 1.1 -0.6 0.1 1.9
Supplements: Fish oil (including cod liver oil) 0.3 0.3 1.0 -0.6 0.2 -0.0 -1.0 0.2 0.9 0.8 -0.4 0.2
High cholesterol (Self-reported) 0.6 1.1 3.9 -0.4 -2.0 1.1 1.4 1.2 -0.2 -0.6 -0.5 0.1
Medication: Bendroflumethiazide 0.1 0.2 0.7 -0.4 -0.2 -0.5 0.1 0.8 -0.3 -0.5 0.1 0.5
Medication: Paracetamol 1.1 1.7 9.9 -1.0 0.3 0.2 -0.7 0.1 1.2 1.4 0.6 3.1
Medication: Lisinopril 1.6 2.1 5.1 -1.8 -1.5 -1.3 1.6 -1.0 -0.6 -1.6 -2.3 -0.7
Medication: Atorvastatin 1.4 1.8 4.4 1.0 -1.2 1.7 1.4 2.1 1.1 0.2 1.5 0.7
Illnesses of father: High blood pressure 0.3 0.4 1.2 -0.5 -0.7 1.1 0.2 -0.6 -0.3 -0.6 -0.3 -0.6
Alcohol drinker status: Never 0.9 1.1 2.5 0.8 0.3 1.6 -1.2 1.2 0.1 1.0 1.5 0.4
Ever smoked 0.6 1.0 1.8 0.8 1.2 1.1 -0.8 1.0 -0.7 1.3 1.3 0.3
Basal metabolic rate 0.3 1.5 5.8 1.0 -0.3 2.4 1.0 1.8 1.2 0.5 0.9 0.2
Leg fat percentage (left) 0.1 0.3 1.0 0.2 -0.1 0.3 0.8 0.5 -0.2 -0.8 0.5 1.0
Arm fat-free mass (left) 0.2 1.1 4.5 0.7 0.2 2.1 0.3 1.6 1.2 0.6 0.6 -0.2
Number of operations (self-reported) 0.6 0.9 5.9 -0.5 -0.2 -0.3 0.5 -0.7 -0.1 -0.2 0.7 2.4
Average weekly beer plus cider intake 1.2 1.7 6.3 -2.5 -1.5 -0.9 0.1 -0.4 0.6 -0.5 -2.1 -1.0
Irritability 0.2 0.3 1.0 -0.4 -0.8 0.3 0.2 0.2 -0.2 -1.0 0.9 0.0
Risk taking 1.5 2.1 3.6 1.9 1.0 1.0 -1.8 0.9 1.9 1.4 1.1 -1.6
Ever had prostate specific antigen (PSA) test 1.2 1.3 6.5 -1.0 0.5 -0.6 -0.4 -2.5 -1.0 -1.7 0.2 0.1
Fractured/broken bones in last 5 years 1.1 1.5 5.4 1.0 -1.0 1.8 0.9 2.3 0.2 0.9 0.8 -0.2
Age started oral contraceptive pill 0.6 0.7 2.2 -1.5 -0.3 -1.3 0.0 -0.9 -1.2 -0.5 -0.4 0.1
Diastolic blood pressure, automated reading 0.9 2.7 7.3 -2.7 -1.7 -1.0 1.7 -0.7 -0.7 -2.2 -2.0 -0.3
Ever depressed for a whole week 0.4 0.4 1.7 -0.2 1.3 0.4 -0.6 0.1 -0.4 0.6 -0.1 -1.1
Unable to work because of sickness or disability 0.8 1.1 2.5 -1.5 0.5 -1.6 -0.6 -0.9 -1.0 -0.5 -1.3 0.6
Commuting to job workplace: Cycle 1.5 1.9 5.6 1.1 -1.4 1.7 1.8 2.4 0.2 0.9 0.4 -0.7
Myopia 0.9 1.3 3.5 -1.9 -1.0 0.3 1.2 -0.1 -1.2 -1.6 -1.0 0.6
Vascular/heart problems diagnosed by doctor 0.5 1.2 6.2 2.5 0.8 0.4 -0.4 0.6 0.7 1.6 0.5 -0.5
Cholesterol lowering medication 1.1 1.6 5.2 -1.2 -0.9 2.0 1.0 2.3 -0.4 0.5 -0.8 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.2 -1.6 -0.3 1.8 -0.3 -0.9 -0.1 -1.4 -0.1 0.3
Pain experienced in last month 0.8 1.4 5.1 0.5 2.3 -0.1 -1.7 0.6 -0.9 0.5 0.9 -1.4
Supplements: Calcium 0.3 0.3 1.4 -0.0 0.7 -0.2 -0.7 -0.1 -1.2 -0.0 0.4 -0.5
Basal cell carcinoma (self-reported) 0.6 0.8 2.8 0.1 0.4 -0.0 0.8 -0.2 -1.1 -1.0 -0.9 -1.7
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.7 -0.2 1.3 0.4 -1.2 0.6 1.2 -0.2 0.5 0.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.7 -0.6 -1.6 0.3 0.6 0.9 1.6 0.3 -0.1 -0.6
Heart disease (siblings) 2.9 3.5 12.0 -2.1 -3.5 1.3 1.5 0.4 0.1 -1.7 -2.2 -1.8
Alcohol drinker status: Previous 0.9 1.0 3.2 1.8 -0.3 0.4 1.2 1.5 0.3 0.5 1.3 -0.4
Pack years of smoking 1.2 1.8 5.9 0.1 0.7 -1.8 -0.7 -2.3 0.2 -0.6 0.4 2.4
Impedance of whole body 0.3 1.3 2.2 -1.5 -0.6 -0.7 -0.2 -0.8 -1.3 -1.5 -1.4 -1.5
Leg fat mass (left) 0.2 0.7 1.6 0.8 -0.3 1.3 1.2 1.2 0.6 -0.4 0.8 0.6
Arm predicted mass (left) 0.3 1.3 4.9 0.9 0.5 2.2 -0.1 1.7 1.1 0.9 1.1 -0.2