Best TWAS P=2.16e-137 · Best GWAS P=1.23e-145 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EZR | 0.06 | 0.02 | enet | 24 | 0.02 | 1.1e-03 | -22.63 | -20.6 | 1.5e-94 | -0.88 | 0.01 | 0.98 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | TULP4 | 0.16 | 0.08 | bslmm | 596 | 0.12 | 2.9e-14 | 2.92 | 5.3 | 1.5e-07 | 0.20 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Artery Aorta | DYNLT1 | 0.17 | 0.16 | lasso | 1 | 0.14 | 5.0e-08 | -6.53 | 6.5 | 6.5e-11 | 0.18 | 0.98 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | DYNLT1 | 0.14 | 0.09 | lasso | 5 | 0.11 | 3.9e-07 | 1.72 | -6.3 | 3.0e-10 | -0.32 | 0.78 | 0.02 | TRUE |
| 5 | GTEx | Muscle Skeletal | EZR | 0.07 | 0.04 | lasso | 5 | 0.03 | 8.2e-04 | -24.09 | -24.9 | 2.2e-137 | -0.59 | 0.67 | 0.12 | TRUE |
| 6 | GTEx | Muscle Skeletal | TULP4 | 0.08 | 0.01 | enet | 20 | 0.02 | 1.9e-03 | 1.79 | -7.2 | 4.4e-13 | -0.34 | 0.24 | 0.32 | TRUE |
| 7 | GTEx | Ovary | DYNLT1 | 0.43 | 0.03 | lasso | 5 | 0.01 | 2.0e-01 | 0.49 | 8.6 | 1.1e-17 | 0.13 | 0.06 | 0.07 | TRUE |
| 8 | GTEx | Stomach | TULP4 | 0.25 | 0.18 | lasso | 7 | 0.16 | 2.6e-08 | -4.95 | -5.5 | 3.2e-08 | -0.07 | 1.00 | 0.00 | TRUE |
| 9 | GTEx | Thyroid | TULP4 | 0.09 | 0.02 | lasso | 4 | 0.03 | 1.4e-03 | -4.84 | -15.0 | 1.0e-50 | -0.54 | 0.10 | 0.45 | TRUE |
| 10 | GTEx | Thyroid | TATDN2P2 | 0.10 | 0.03 | lasso | 3 | 0.02 | 1.1e-02 | 3.24 | -5.6 | 2.1e-08 | -0.17 | 0.38 | 0.04 | FALSE |
| 11 | METSIM | Adipose | DYNLT1 | 0.06 | 0.03 | enet | 14 | 0.03 | 9.3e-06 | 1.72 | -5.1 | 2.8e-07 | -0.18 | 0.99 | 0.00 | FALSE |
| 12 | NTR | Blood | DYNLT1 | 0.04 | 0.00 | bslmm | 497 | 0.02 | 6.0e-07 | 1.41 | -8.8 | 8.7e-19 | -0.31 | 0.21 | 0.06 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | EZR | 0.11 | 0.11 | lasso | 8 | 0.12 | 8.3e-15 | -19.08 | -22.3 | 3.9e-110 | -0.88 | 0.11 | 0.89 | TRUE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TULP4 | 0.09 | 0.05 | blup | 148 | 0.04 | 2.0e-05 | -2.39 | 6.0 | 1.7e-09 | 0.09 | 0.77 | 0.01 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DYNLT1 | 0.04 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | -6.55 | -6.5 | 5.7e-11 | -0.18 | 0.02 | 0.83 | TRUE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EZR | 0.14 | 0.00 | blup | 75 | 0.02 | 1.8e-02 | 1.55 | -16.7 | 1.9e-62 | -0.42 | 0.01 | 0.08 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | EZR | 0.03 | 0.03 | lasso | 2 | 0.02 | 9.2e-04 | -10.84 | -11.1 | 2.1e-28 | -0.39 | 0.06 | 0.36 | TRUE |