Best TWAS P=5.16e-37 · Best GWAS P=1.54e-36 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | CREM | 0.15 | 0.12 | enet | 11 | 0.15 | 1.3e-05 | 12.5 | -12.3 | 5.6e-35 | -0.99 | 0.05 | 0.94 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CREM | 0.06 | 0.03 | enet | 3 | 0.03 | 1.6e-03 | 6.4 | -10.6 | 2.8e-26 | -0.87 | 0.05 | 0.84 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | CUL2 | 0.07 | 0.02 | enet | 4 | 0.00 | 2.5e-01 | 8.6 | -8.6 | 5.9e-18 | -0.64 | 0.27 | 0.24 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | PARD3 | 0.15 | 0.07 | lasso | 6 | 0.12 | 2.0e-09 | -6.3 | 5.6 | 1.7e-08 | 0.11 | 0.98 | 0.01 | TRUE |
| 5 | NTR | Blood | CUL2 | 0.04 | 0.09 | lasso | 13 | 0.09 | 4.4e-26 | 12.5 | -12.6 | 1.5e-36 | -1.00 | 0.04 | 0.96 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | CREM | 0.03 | 0.02 | enet | 26 | 0.03 | 3.3e-05 | 12.4 | -11.0 | 2.7e-28 | -0.88 | 0.05 | 0.95 | FALSE |
| 7 | YFS | Blood | CCNY | 0.02 | 0.00 | blup | 447 | 0.01 | 4.6e-04 | 1.1 | -5.6 | 2.3e-08 | -0.52 | 0.30 | 0.21 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CUL2 | 0.02 | 0.02 | blup | 64 | 0.01 | 7.6e-02 | 12.6 | -12.7 | 5.2e-37 | -0.99 | 0.03 | 0.89 | TRUE |