Best TWAS P=7.95e-11 · Best GWAS P=2.6e-13 conditioned to 0.000931
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | ADD3 | 0.06 | 0.03 | enet | 7 | 0.04 | 4.1e-03 | -6.0 | -6.0 | 1.8e-09 | 0.00 | 0.03 | 0.95 | TRUE |
| 2 | GTEx | Artery Aorta | ADD3 | 0.12 | 0.10 | lasso | 3 | 0.11 | 9.4e-07 | -5.4 | -5.6 | 1.7e-08 | -0.03 | 0.05 | 0.95 | FALSE |
| 3 | GTEx | Artery Tibial | ADRA2A | 0.09 | 0.05 | lasso | 5 | 0.01 | 2.5e-02 | 6.1 | 5.1 | 2.8e-07 | 0.76 | 0.03 | 0.94 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | ADD3 | 0.40 | 0.34 | lasso | 6 | 0.45 | 4.2e-13 | -5.8 | -5.8 | 9.0e-09 | 0.01 | 0.05 | 0.95 | FALSE |
| 5 | GTEx | Brain Cerebellum | ADD3 | 0.36 | 0.31 | lasso | 11 | 0.33 | 1.4e-10 | -5.8 | -5.5 | 3.9e-08 | 0.00 | 0.05 | 0.95 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | ADD3 | 0.08 | 0.05 | lasso | 3 | 0.04 | 3.4e-03 | -5.4 | -5.6 | 2.1e-08 | -0.02 | 0.03 | 0.78 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Female) | ADD3 | 0.07 | 0.02 | lasso | 1 | 0.09 | 1.3e-03 | -5.9 | -5.8 | 4.9e-09 | 0.01 | 0.04 | 0.47 | FALSE |
| 8 | GTEx | Colon Sigmoid | ADD3 | 0.10 | 0.04 | lasso | 7 | 0.03 | 3.3e-02 | -5.3 | -5.7 | 1.2e-08 | -0.02 | 0.04 | 0.87 | FALSE |
| 9 | GTEx | Heart Left Ventricle | ADD3 | 0.10 | 0.02 | enet | 17 | 0.03 | 1.2e-02 | -6.0 | -5.3 | 8.9e-08 | 0.04 | 0.04 | 0.95 | FALSE |
| 10 | GTEx | Lung | ADD3 | 0.07 | 0.05 | lasso | 4 | 0.04 | 2.2e-04 | -5.6 | -5.7 | 1.5e-08 | -0.01 | 0.09 | 0.90 | FALSE |
| 11 | GTEx | Nerve Tibial | ADD3 | 0.08 | 0.07 | lasso | 3 | 0.04 | 4.3e-04 | -5.4 | -5.8 | 7.9e-09 | -0.01 | 0.04 | 0.96 | FALSE |
| 12 | GTEx | Pituitary | ADD3 | 0.27 | 0.05 | enet | 9 | 0.08 | 4.0e-03 | -4.8 | -5.9 | 3.4e-09 | -0.02 | 0.05 | 0.85 | FALSE |
| 13 | GTEx | Spleen | XPNPEP1 | 0.25 | 0.04 | lasso | 5 | 0.05 | 2.4e-02 | -4.8 | -5.7 | 1.1e-08 | -0.02 | 0.04 | 0.50 | FALSE |
| 14 | GTEx | Spleen | ADD3 | 0.36 | 0.27 | lasso | 5 | 0.28 | 7.2e-08 | -5.4 | -5.8 | 5.9e-09 | -0.01 | 0.05 | 0.92 | FALSE |
| 15 | GTEx | Thyroid | ADD3 | 0.06 | 0.00 | enet | 4 | 0.01 | 1.2e-01 | -5.1 | -5.6 | 2.7e-08 | -0.01 | 0.05 | 0.72 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | ADD3 | 0.04 | 0.03 | lasso | 4 | 0.02 | 2.1e-03 | -6.0 | -5.8 | 7.0e-09 | 0.01 | 0.02 | 0.97 | FALSE |
| 17 | YFS | Blood | PDCD4 | 0.25 | 0.23 | enet | 47 | 0.33 | 3.3e-110 | 2.0 | 5.2 | 2.0e-07 | 0.66 | 1.00 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADD3 | 0.04 | 0.03 | lasso | 2 | 0.02 | 8.5e-04 | -5.2 | -5.9 | 3.3e-09 | -0.04 | 0.05 | 0.52 | FALSE |
| 19 | The Cancer Genome Atlas | Rectum Adenocarcinoma | LOC282997 | 0.27 | 0.07 | lasso | 2 | 0.09 | 3.5e-03 | 6.5 | -6.5 | 7.9e-11 | -0.88 | 0.00 | 0.88 | TRUE |