Hub : Genes

ADRA2A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0840 0.0350 0.0059 0.001 0.008 0.001 0.013 -0.002 0.25000 0.033 0.22 0.0079 0.870
2 GTEx Artery Tibial 0.0871 0.0354 0.0043 0.046 NA 0.005 NA 0.014 0.00016 NA 0.12 NA 0.025

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.9 3.0 5.4 -0.8 2.3
Bipolar Disorder or Schizophrenia 0.8 2.0 2.6 -1.6 1.2
Depressed Affect (Nagel 2018) 0.3 0.5 0.8 0.9 -0.5
Depression (Nagel 2018) 1.3 2.0 3.3 1.8 -0.8
Intelligence (Savage-Jansen 2018) 0.3 1.1 1.9 1.4 -0.4
Neuroticism (Nagel 2018) 0.2 0.5 0.9 1.0 -0.1
Schizophrenia (2018) 0.5 1.0 1.8 -1.3 -0.4
Schizophrenia vs Biploar Disorder 0.8 1.1 2.1 0.4 -1.4
Worry (Nagel 2018) 0.3 0.6 0.9 0.9 0.6
Alzheimer’s Disease (in mother) 2.3 2.7 4.9 0.7 2.2
Alzheimer’s Disease (in father) 0.6 0.7 0.7 -0.8 0.8
Alzheimer’s Disease (including proxy) 3.5 5.1 9.6 -0.8 3.1
Crohns Disease (2017) 0.2 0.4 0.7 0.8 0.2
Irritable Bowel Disease (IBD) 0.8 1.8 2.3 1.5 -1.1
Ulcerative Colitis (UC) 1.5 2.9 4.5 1.1 -2.1
Major Depression (MDD) 1.4 1.7 2.5 1.6 -0.9
Reaction Time 0.2 0.4 0.8 0.2 0.9
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.5 0.3 -1.6
Breast Cancer 0.0 0.0 0.0 -0.1 0.1
Ovarian Cancer 1.4 1.8 2.4 1.2 -1.5
Prostate Cancer 1.4 2.0 3.0 1.7 -1.0
Age at First Birth 0.0 0.0 0.0 -0.2 -0.2
Bipolar Disorder (2011) 0.7 0.7 1.2 -1.1 0.4
Body Mass Index (BMI) (2010) 1.0 1.4 1.9 1.4 -0.9
Coronary Artery Disease (CAD) 0.4 0.5 0.6 0.6 -0.8
Crohns Disease (2012) 0.6 0.9 1.3 0.7 1.1
Mean Putamen Volume 0.1 0.1 0.2 0.0 -0.5
Fasting Glucose 9.5 11.3 17.9 4.2 -2.2
HbA1C 0.4 0.5 0.9 1.0 0.1
HDL Cholesterol 1.2 2.0 3.3 -0.8 1.8
LDL Cholesterol 0.2 0.2 0.4 0.2 0.7
Lupus 0.9 1.3 2.0 1.4 -0.8
Neuroticism (2016) 0.9 1.2 1.5 1.2 1.0
Primary Biliary Cirrhosis 0.3 0.5 0.7 0.5 -0.8
Rheumatoid Arthritis 2.1 2.8 5.3 2.3 -0.6
Schizophrenia (2014) 0.4 0.9 1.5 -0.5 1.2
Triglycerides 0.8 1.4 2.2 1.5 -0.7
Type 2 Diabetes (T2D) (2012) 6.2 7.2 10.6 3.2 -1.9
Ulcerative Colitis 0.4 0.6 1.3 0.0 -1.1
Blood Eosinophil Count 0.2 1.2 2.1 -0.6 1.5
Blood Platelet Count 0.0 0.2 0.3 -0.4 -0.5
Blood Red Count 0.4 4.0 7.3 -0.8 2.7
Blood White Count 0.1 0.6 1.1 1.1 0.1
Heel T-Score 0.4 2.9 5.8 0.3 2.4
BMI 0.2 1.1 1.7 0.8 -1.3
Height 0.0 0.2 0.3 0.5 0.4
Waist Hip Ratio (WHR) 0.1 0.3 0.4 -0.5 0.6
Systolic Blood Pressure 1.2 6.1 9.9 -1.5 3.1
Smoking Status 0.4 1.1 1.6 1.2 -0.7
Allergy or Eczema 0.0 0.1 0.1 -0.4 -0.2
Cardiovascular Disease 0.6 2.0 4.0 0.1 2.0
Hypothyroidism (self reported) 0.5 1.1 2.0 -0.4 1.4
Respiratory disease 0.6 1.4 2.4 -0.6 1.5
Type 2 Diabetes (T2D) (2018) 2.3 4.3 6.4 1.5 -2.5
Lung FEV1/FVC ratio 0.3 1.4 2.0 0.9 1.4
Lung FVC 0.5 2.4 3.0 1.3 -1.7
Neuroticism 0.1 0.2 0.4 0.6 0.0
Chronotype (morning person) 0.1 0.3 0.6 0.1 0.8
Hair Pigment 0.5 14.3 26.4 -1.5 5.1
Tanning 0.0 0.5 0.6 0.7 -0.8
Hand grip strength (left) 1.2 3.0 3.9 1.5 2.0
Number of treatments/medications taken 0.3 0.5 0.7 -0.5 0.9
Average weekly spirits intake 1.0 1.2 2.2 1.5 0.4
Sensitivity / hurt feelings 0.5 0.8 0.8 0.9 -0.9
Frequency of depressed mood in last 2 weeks 1.6 2.2 4.2 2.0 -0.4
Hearing difficulty/problems: Yes 0.2 0.3 0.6 0.8 -0.3
Relative age of first facial hair 0.4 0.8 1.1 -1.1 0.6
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.3 -0.5 -1.1
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.4 -1.2 -0.1
Ever had hysterectomy (womb removed) 1.6 1.8 3.1 -0.8 1.8
Systolic blood pressure, automated reading 0.5 1.4 2.6 -0.5 1.6
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.3 -0.4
Angina 0.6 0.8 1.1 0.7 -1.0
Medication for hormone replacement therapy 0.3 0.3 0.5 0.3 0.7
Vitamin and mineral supplements 0.3 0.5 0.7 0.5 0.8
Supplements: Zinc 1.3 1.4 2.5 -0.5 1.6
Medication: Co-codamol 0.2 0.2 0.3 -0.5 0.5
Medication: Metformin 0.7 1.0 1.9 0.2 -1.4
Diabetes (father) 4.2 5.2 7.3 1.8 -2.7
Diabetes (mother) 2.7 3.5 6.9 0.3 -2.6
Severe depression (siblings) 0.6 0.7 1.3 -1.1 -0.2
Pack years adult smoking proportion 0.9 1.4 1.9 -1.4 -1.0
Impedance of leg (right) 0.6 2.8 5.3 -0.6 2.3
Leg fat-free mass (left) 0.1 0.5 0.8 0.9 -0.5
Trunk fat percentage 0.0 0.1 0.2 -0.3 -0.4
Hand grip strength (right) 0.5 1.4 2.8 1.7 0.1
Townsend deprivation index at recruitment 0.3 0.5 1.0 -0.1 1.0
Current tobacco smoking 0.3 0.5 0.6 0.6 -0.7
Average weekly fortified wine intake 0.3 0.3 0.4 0.5 0.6
Maternal smoking around birth 1.6 2.4 4.6 0.4 2.1
Fed-up feelings 2.1 3.9 5.6 2.4 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.3 1.5 0.4
Relative age voice broke 0.4 0.6 1.1 0.2 -1.1
Taking other prescription medications 0.4 0.7 1.3 0.1 1.1
Age when periods started (menarche) 0.2 0.6 1.1 1.1 -0.2
Bilateral oophorectomy (both ovaries removed) 2.6 3.0 4.3 -2.1 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 2.8 -0.5 1.7
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.1 -0.2 0.0
Qualifications: CSEs or equivalent 0.7 0.9 1.8 1.3 -0.1
Serious illness, injury or assault to yourself 0.2 0.3 0.5 0.2 0.7
High blood pressure 0.1 0.2 0.3 -0.2 0.6
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.6 -0.8 -0.4
Multivitamins +/- minerals 0.1 0.1 0.2 0.4 -0.3
Stomach or abdominal pain in last month 0.2 0.3 0.5 -0.3 -0.7
Supplements: Glucosamine 0.0 0.1 0.1 -0.2 0.3
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 0.7 -0.7 -0.8
Medication: Atenolol 0.9 1.2 2.2 1.5 -0.3
Medication: Levothyroxine sodium 0.5 0.9 1.2 -0.7 1.1
Sitting height 0.0 0.2 0.3 0.1 0.6
Chronic bronchitis/emphysema (father) 0.5 0.6 0.8 -0.9 -0.6
High blood pressure (mother) 3.0 4.2 8.4 -0.1 -2.9
Body mass index (BMI) 0.1 0.6 1.2 0.1 -1.1
Impedance of leg (left) 0.3 1.4 1.6 -1.1 1.3
Leg predicted mass (left) 0.1 0.6 0.8 0.9 -0.5
Trunk fat mass 0.0 0.1 0.2 -0.1 -0.4
Waist circumference 0.1 0.3 0.6 0.8 -0.2
Number of incorrect matches in round 1.2 2.1 4.1 -0.2 2.0
Past tobacco smoking 0.4 0.8 1.5 -1.2 0.2
Alcohol usually taken with meals 0.2 0.3 0.6 -0.3 -0.8
Nervous feelings 0.2 0.3 0.4 0.6 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.3 -0.3 1.1
Hearing difficulty/problems with background noise 1.3 2.1 3.3 1.8 0.9
Hair/balding pattern: Pattern 2 0.4 0.5 0.7 0.6 0.8
Had menopause 0.9 1.1 1.4 -1.2 -0.9
Had other major operations 0.2 0.2 0.3 -0.3 -0.5
Forced vital capacity (FVC) 0.1 0.4 0.5 -0.5 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 1.4 -1.0 1.2
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.1 0.2 0.4
Qualifications: None of the above 0.1 0.1 0.2 0.1 -0.5
Financial difficulties in last 2 years 1.4 1.9 2.6 1.1 1.6
Mouth/teeth dental problems 0.1 0.1 0.1 -0.3 0.4
Heart attack 0.2 0.2 0.3 0.6 0.4
Allergy 0.5 1.2 2.3 1.5 -0.4
Pain all over the body in last month 1.3 1.4 2.8 1.7 0.2
Diabetes (self-reported) 1.9 3.0 4.3 1.3 -2.1
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 0.9 -0.8 0.9
Medication: Ramipril 0.9 1.2 2.1 -1.4 0.5
Medication: Simvastatin 0.3 0.5 0.5 -0.7 0.7
Fluid intelligence score 0.0 0.0 0.0 0.1 -0.1
Illnesses of siblings 0.2 0.3 0.6 0.8 -0.1
Neuroticism score 0.1 0.3 0.5 0.7 0.1
Weight 0.0 0.1 0.2 0.3 -0.5
Impedance of arm (right) 0.1 0.4 0.7 -0.3 0.8
Arm fat percentage (right) 0.0 0.1 0.2 0.0 -0.5
Trunk fat-free mass 0.1 0.3 0.4 0.6 0.5
Hip circumference 0.1 0.4 0.8 0.9 -0.0
Time employed in main current job 0.9 1.1 1.7 -0.7 1.3
Alcohol intake versus 10 years previously 0.1 0.2 0.3 0.6 0.0
Father’s age at death 2.0 2.7 5.4 -0.2 -2.3
Worrier / anxious feelings 1.2 2.3 4.5 2.1 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.1 0.4 0.3
Falls in the last year 0.1 0.1 0.1 -0.4 -0.2
Hair/balding pattern: Pattern 3 0.6 0.9 1.8 0.1 -1.3
Number of live births 0.3 0.5 0.5 0.7 -0.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.6 -0.1 -0.8
Pulse rate 0.9 1.5 2.6 1.6 0.7
Happiness 0.9 1.1 1.6 -1.3 0.8
Noisy workplace 1.4 1.7 3.1 1.8 0.5
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.5 -1.2 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.1 1.0 -0.5
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 -0.4 -0.1
Asthma 1.0 2.0 2.9 -1.7 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.4 0.6 -0.4
Medication: Cholesterol lowering 0.0 0.0 0.0 -0.2 0.1
Depression (self-reported) 0.2 0.3 0.6 -0.8 0.1
Medication: Lansoprazole 3.6 4.1 8.3 0.0 -2.9
Prospective memory result 1.0 1.2 2.1 1.5 -0.5
Lung cancer (father) 1.0 1.2 2.3 0.3 1.5
Illnesses of mother 0.2 0.2 0.4 0.3 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 1.3 1.1 -1.1
Pulse wave Arterial Stiffness index 2.2 2.5 3.1 1.8 -1.4
Impedance of arm (left) 0.1 0.4 0.8 -0.1 0.9
Arm fat mass (right) 0.1 0.2 0.4 0.3 -0.6
Trunk predicted mass 0.1 0.3 0.4 0.7 0.5
Standing height 0.1 0.7 1.3 0.3 1.1
Length of working week for main job 0.9 1.0 1.6 0.7 -1.3
Exposure to tobacco smoke at home 0.4 0.5 0.6 0.6 0.8
Breastfed as a baby 0.8 1.0 1.8 -0.5 -1.4
Tense / ‘highly strung’ 0.4 0.6 1.1 -0.4 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.1 1.0 -0.5
Hair/balding pattern: Pattern 4 1.1 2.7 5.4 -0.2 2.3
Birth weight of first child 0.9 1.6 3.1 -1.8 0.2
Peak expiratory flow (PEF) 0.1 0.3 0.4 -0.3 0.7
Pulse wave reflection index 0.1 0.1 0.2 -0.0 0.4
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.3 -0.2 -1.5
Loud music exposure frequency 0.2 0.2 0.4 0.1 -0.6
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 -0.5 0.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.5 0.7 -0.2
Blood clot in the leg (DVT) 0.1 0.1 0.3 0.0 0.5
Medication: Paracetamol 0.5 0.9 1.8 1.4 -0.0
Headache pain in last month 0.9 1.6 2.1 -1.1 -1.4
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.1 -0.2 0.3
Glaucoma (self-reported) 1.2 1.4 2.6 -0.6 1.6
Gout (self-reported) 0.1 0.1 0.1 -0.3 0.3
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 1.3 -1.2 0.9
Medication: Amlodipine 0.8 1.1 1.7 1.3 0.6
Medication: Ventolin 100micrograms inhaler 1.4 1.9 3.5 -0.5 1.9
Birth weight 1.9 4.1 7.8 -0.6 -2.8
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.3 0.6 0.5
High blood pressure (siblings) 0.9 1.3 2.5 -1.6 0.4
Forced vital capacity (FVC), Best measure 0.1 0.2 0.3 0.4 -0.6
Body fat percentage 0.0 0.2 0.3 -0.3 -0.5
Leg fat percentage (right) 0.0 0.0 0.0 0.1 0.2
Arm fat-free mass (right) 0.0 0.2 0.2 0.4 -0.4
Exposure to tobacco smoke outside home 0.6 0.9 1.7 0.2 -1.3
Comparative body size at age 10 1.5 4.2 8.2 0.5 -2.9
Number of full brothers 0.5 0.6 1.0 -0.4 1.0
Worry too long after embarrassment 0.5 0.8 1.1 1.0 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 3.3 0.6 1.8
Wheeze or whistling in the chest in last year 0.2 0.4 0.6 -0.5 0.8
Number of children fathered 0.1 0.1 0.2 0.2 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.3 0.2 1.1
Age at first live birth 0.4 0.7 1.0 -1.0 0.7
Pulse wave peak to peak time 1.8 2.1 2.5 -1.6 1.3
Health satisfaction 0.1 0.1 0.2 -0.4 -0.2
Shortness of breath walking on level ground 0.7 0.9 1.0 0.9 -1.0
Qualifications: College or University degree 0.2 0.5 0.7 -0.8 -0.6
Eye problems/disorders: None of the above 1.1 1.2 2.4 0.2 1.6
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.4 -0.3 0.6
Emphysema/chronic bronchitis 0.9 1.0 1.7 0.6 1.3
Medication for pain relief, constipation, heartburn 0.3 0.5 0.5 -0.7 0.7
Neck or shoulder pain in last month 0.3 0.4 0.8 0.9 -0.3
Medication: Blood pressure 0.0 0.0 0.0 -0.1 0.2
Angina (self-reported) 0.7 0.9 1.3 0.7 -1.1
Migraine (self-reported) 0.5 0.6 1.0 1.0 -0.5
Medication: Ibuprofen 0.2 0.2 0.3 0.5 -0.4
Medication: Allopurinol 0.1 0.2 0.3 -0.5 -0.1
Medication: Omeprazole 0.2 0.3 0.3 -0.5 0.5
Medication: Seretide 50 evohaler 2.3 2.7 5.0 -0.6 2.2
Mean time to correctly identify matches 0.4 0.8 1.6 -0.3 1.3
Heart disease (mother) 0.1 0.1 0.1 -0.3 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 1.4 0.8 1.2
Whole body fat mass 0.0 0.2 0.3 -0.0 -0.6
Leg fat mass (right) 0.0 0.1 0.1 0.2 -0.3
Arm predicted mass (right) 0.0 0.2 0.2 0.4 -0.4
Pulse rate, automated reading 2.8 9.1 16.8 4.1 -1.1
Alcohol intake frequency. 0.6 1.4 1.4 -1.2 -1.1
Comparative height size at age 10 0.2 1.0 1.8 0.4 1.3
Number of full sisters 0.1 0.1 0.2 -0.1 0.4
Suffer from ‘nerves’ 0.1 0.2 0.2 -0.5 0.4
Overall health rating 0.7 1.6 2.4 1.5 -0.9
Chest pain or discomfort 0.3 0.4 0.8 -0.4 0.9
Had major operations 0.0 0.0 0.1 -0.2 0.2
Age at last live birth 0.1 0.2 0.3 -0.3 0.5
Family relationship satisfaction 0.2 0.2 0.3 -0.4 0.5
Leg pain on walking 0.1 0.1 0.1 -0.4 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 0.8 0.9 0.3
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.1 0.0 1.1
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 3.7 -1.9 0.3
Medication: Aspirin 0.0 0.0 0.0 -0.1 0.2
Supplements: Vitamin C 0.1 0.1 0.1 -0.4 -0.2
Knee pain experienced in last month 0.2 0.4 0.5 0.7 0.5
Hypertension (Self-reported) 0.1 0.3 0.5 -0.1 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 0.4 -0.4
Illnesses of father: Heart disease 0.2 0.2 0.2 -0.5 -0.4
Illnesses of siblings: Diabetes 1.0 1.2 2.0 1.4 -0.7
Smoking status: Previous 0.4 0.5 1.0 1.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.7 -0.8 0.1
Whole body fat-free mass 0.0 0.2 0.4 0.7 -0.0
Leg fat-free mass (right) 0.1 0.6 0.9 0.4 -1.0
Arm fat percentage (left) 0.0 0.1 0.2 0.3 -0.5
Average weekly red wine intake 0.5 0.7 0.8 0.8 -0.9
Handedness (chirality/laterality): Left-handed 1.7 2.1 4.1 -0.2 2.0
Mood swings 0.2 0.3 0.6 0.3 0.8
Loneliness, isolation 0.0 0.1 0.1 0.2 0.3
Long-standing illness, disability or infirmity 0.0 0.0 0.1 0.1 -0.3
Ever had bowel cancer screening 0.7 0.8 1.3 -1.2 0.5
Diabetes diagnosed by doctor 2.4 3.9 6.0 1.3 -2.5
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.8 1.3 0.2
Friendships satisfaction 0.3 0.4 0.5 0.7 -0.5
Qualifications: nursing, teaching 0.1 0.1 0.2 -0.5 -0.0
Commuting to job workplace: Walk 0.0 0.0 0.1 0.3 -0.2
Eye problems/disorders: Cataract 2.0 2.3 4.5 0.3 -2.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.6 0.5 -0.7
Medication for cholesterol 1.4 2.2 4.3 -0.2 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.9 -1.0 -0.5
Back pain experienced in last month 0.6 0.9 1.6 -1.3 0.3
Mineral and other dietary supplements 0.4 0.5 0.6 0.7 -0.7
Breast cancer (self-reported) 3.6 4.3 7.8 2.8 0.9
Asthma (self-reported) 1.1 2.2 3.2 -1.8 1.1
Osteoporosis (self-reported) 0.0 0.1 0.1 0.3 -0.1
Osteoarthritis (self-reported) 0.2 0.3 0.4 -0.4 -0.6
Medication: Aspirin 0.1 0.1 0.2 -0.1 0.4
Medication: Gliclazide 0.1 0.1 0.2 -0.4 0.3
Illnesses of father: None of the above (group 1) 0.7 0.9 1.1 1.1 0.8
Smoking status: Current 0.6 0.9 1.3 0.8 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 0.8 0.9 -0.6
Whole body water mass 0.0 0.2 0.4 0.7 -0.0
Leg predicted mass (right) 0.1 0.5 0.8 0.4 -0.9
Arm fat mass (left) 0.1 0.4 0.6 0.3 -0.8
Number of self-reported non-cancer illnesses 1.2 2.1 3.8 0.5 1.9
Average weekly champagne plus white wine intake 1.0 1.3 1.7 -1.3 -1.0
Miserableness 0.2 0.3 0.7 0.8 0.1
Guilty feelings 0.3 0.5 1.0 -0.0 1.0
Wears glasses or contact lenses 0.1 0.1 0.1 -0.1 -0.4
Ever taken oral contraceptive pill 0.7 0.8 1.5 0.2 1.2
Hearing aid user 0.6 0.7 1.4 0.3 -1.2
Mother’s age at death 0.1 0.1 0.2 -0.3 0.5
Financial situation satisfaction 1.4 1.8 3.1 -0.7 1.8
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 0.1 0.7
Commuting to job workplace: Public transport 1.6 1.9 3.8 -0.2 -1.9
Eye problems/disorders: Glaucoma 0.3 0.4 0.4 0.6 0.7
Medication: Blood pressure 0.3 0.5 0.9 -0.4 0.9
Pain type(s) experienced in last month: Hip pain 1.4 1.8 2.0 -1.4 1.3
Supplements: Fish oil (including cod liver oil) 0.0 0.1 0.1 0.3 -0.2
High cholesterol (Self-reported) 0.7 1.2 1.8 1.3 0.8
Medication: Bendroflumethiazide 0.1 0.2 0.2 -0.5 -0.3
Medication: Paracetamol 0.0 0.0 0.0 0.2 -0.1
Medication: Lisinopril 0.9 1.1 1.8 1.4 -0.6
Medication: Atorvastatin 2.2 2.8 3.5 1.9 1.4
Illnesses of father: High blood pressure 0.4 0.5 0.9 -1.0 -0.2
Alcohol drinker status: Never 2.0 2.4 4.8 -2.2 -0.0
Ever smoked 0.5 0.8 1.5 1.2 -0.3
Basal metabolic rate 0.0 0.2 0.4 0.6 -0.3
Leg fat percentage (left) 0.0 0.2 0.2 -0.3 -0.5
Arm fat-free mass (left) 0.0 0.2 0.3 0.4 -0.5
Number of operations (self-reported) 1.1 1.6 2.7 0.7 -1.7
Average weekly beer plus cider intake 1.5 2.2 3.0 -1.2 1.7
Irritability 0.2 0.3 0.4 0.6 -0.5
Risk taking 0.5 0.7 1.2 -0.4 1.1
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 -0.5 0.1
Fractured/broken bones in last 5 years 1.7 2.2 4.0 -0.7 -2.0
Age started oral contraceptive pill 0.2 0.3 0.5 -0.3 0.7
Diastolic blood pressure, automated reading 1.1 3.3 6.2 0.6 2.5
Ever depressed for a whole week 0.2 0.2 0.4 0.6 0.0
Unable to work because of sickness or disability 0.4 0.5 1.0 1.0 0.1
Commuting to job workplace: Cycle 2.2 2.7 5.3 -2.3 0.2
Myopia 0.2 0.3 0.7 0.8 -0.1
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.3 0.0 -0.6
Cholesterol lowering medication 0.5 0.7 0.9 0.8 0.9
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.1 -0.3 0.3
Pain experienced in last month 0.5 0.8 1.3 -0.6 1.2
Supplements: Calcium 0.4 0.5 0.6 -0.8 0.6
Basal cell carcinoma (self-reported) 0.5 0.5 0.6 0.7 0.8
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.3 0.5 0.5
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.5 0.5 0.7
Heart disease (siblings) 0.6 0.7 0.9 0.7 1.0
Alcohol drinker status: Previous 1.7 1.9 3.7 -0.3 1.9
Pack years of smoking 1.2 1.8 2.8 -1.7 -0.9
Impedance of whole body 0.1 0.8 1.2 -0.6 1.1
Leg fat mass (left) 0.1 0.4 0.7 0.0 -0.9
Arm predicted mass (left) 0.0 0.1 0.2 0.4 -0.2