Hub : Genes

ADRA2A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0840	0.0350	0.0059	0.001	0.008	0.001	0.013	-0.002	0.25000	0.033	0.22	0.0079	0.870
2	GTEx	Artery Tibial	0.0871	0.0354	0.0043	0.046	NA	0.005	NA	0.014	0.00016	NA	0.12	NA	0.025

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder (2018)	1.9	3.0	5.4	-0.8	2.3
Bipolar Disorder or Schizophrenia	0.8	2.0	2.6	-1.6	1.2
Depressed Affect (Nagel 2018)	0.3	0.5	0.8	0.9	-0.5
Depression (Nagel 2018)	1.3	2.0	3.3	1.8	-0.8
Intelligence (Savage-Jansen 2018)	0.3	1.1	1.9	1.4	-0.4
Neuroticism (Nagel 2018)	0.2	0.5	0.9	1.0	-0.1
Schizophrenia (2018)	0.5	1.0	1.8	-1.3	-0.4
Schizophrenia vs Biploar Disorder	0.8	1.1	2.1	0.4	-1.4
Worry (Nagel 2018)	0.3	0.6	0.9	0.9	0.6
Alzheimer’s Disease (in mother)	2.3	2.7	4.9	0.7	2.2
Alzheimer’s Disease (in father)	0.6	0.7	0.7	-0.8	0.8
Alzheimer’s Disease (including proxy)	3.5	5.1	9.6	-0.8	3.1
Crohns Disease (2017)	0.2	0.4	0.7	0.8	0.2
Irritable Bowel Disease (IBD)	0.8	1.8	2.3	1.5	-1.1
Ulcerative Colitis (UC)	1.5	2.9	4.5	1.1	-2.1
Major Depression (MDD)	1.4	1.7	2.5	1.6	-0.9
Reaction Time	0.2	0.4	0.8	0.2	0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.5	0.3	-1.6
Breast Cancer	0.0	0.0	0.0	-0.1	0.1
Ovarian Cancer	1.4	1.8	2.4	1.2	-1.5
Prostate Cancer	1.4	2.0	3.0	1.7	-1.0
Age at First Birth	0.0	0.0	0.0	-0.2	-0.2
Bipolar Disorder (2011)	0.7	0.7	1.2	-1.1	0.4
Body Mass Index (BMI) (2010)	1.0	1.4	1.9	1.4	-0.9
Coronary Artery Disease (CAD)	0.4	0.5	0.6	0.6	-0.8
Crohns Disease (2012)	0.6	0.9	1.3	0.7	1.1
Mean Putamen Volume	0.1	0.1	0.2	0.0	-0.5
Fasting Glucose	9.5	11.3	17.9	4.2	-2.2
HbA1C	0.4	0.5	0.9	1.0	0.1
HDL Cholesterol	1.2	2.0	3.3	-0.8	1.8
LDL Cholesterol	0.2	0.2	0.4	0.2	0.7
Lupus	0.9	1.3	2.0	1.4	-0.8
Neuroticism (2016)	0.9	1.2	1.5	1.2	1.0
Primary Biliary Cirrhosis	0.3	0.5	0.7	0.5	-0.8
Rheumatoid Arthritis	2.1	2.8	5.3	2.3	-0.6
Schizophrenia (2014)	0.4	0.9	1.5	-0.5	1.2
Triglycerides	0.8	1.4	2.2	1.5	-0.7
Type 2 Diabetes (T2D) (2012)	6.2	7.2	10.6	3.2	-1.9
Ulcerative Colitis	0.4	0.6	1.3	0.0	-1.1
Blood Eosinophil Count	0.2	1.2	2.1	-0.6	1.5
Blood Platelet Count	0.0	0.2	0.3	-0.4	-0.5
Blood Red Count	0.4	4.0	7.3	-0.8	2.7
Blood White Count	0.1	0.6	1.1	1.1	0.1
Heel T-Score	0.4	2.9	5.8	0.3	2.4
BMI	0.2	1.1	1.7	0.8	-1.3
Height	0.0	0.2	0.3	0.5	0.4
Waist Hip Ratio (WHR)	0.1	0.3	0.4	-0.5	0.6
Systolic Blood Pressure	1.2	6.1	9.9	-1.5	3.1
Smoking Status	0.4	1.1	1.6	1.2	-0.7
Allergy or Eczema	0.0	0.1	0.1	-0.4	-0.2
Cardiovascular Disease	0.6	2.0	4.0	0.1	2.0
Hypothyroidism (self reported)	0.5	1.1	2.0	-0.4	1.4
Respiratory disease	0.6	1.4	2.4	-0.6	1.5
Type 2 Diabetes (T2D) (2018)	2.3	4.3	6.4	1.5	-2.5
Lung FEV1/FVC ratio	0.3	1.4	2.0	0.9	1.4
Lung FVC	0.5	2.4	3.0	1.3	-1.7
Neuroticism	0.1	0.2	0.4	0.6	0.0
Chronotype (morning person)	0.1	0.3	0.6	0.1	0.8
Hair Pigment	0.5	14.3	26.4	-1.5	5.1
Tanning	0.0	0.5	0.6	0.7	-0.8
Hand grip strength (left)	1.2	3.0	3.9	1.5	2.0
Number of treatments/medications taken	0.3	0.5	0.7	-0.5	0.9
Average weekly spirits intake	1.0	1.2	2.2	1.5	0.4
Sensitivity / hurt feelings	0.5	0.8	0.8	0.9	-0.9
Frequency of depressed mood in last 2 weeks	1.6	2.2	4.2	2.0	-0.4
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.8	-0.3
Relative age of first facial hair	0.4	0.8	1.1	-1.1	0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.3	-0.5	-1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.4	-1.2	-0.1
Ever had hysterectomy (womb removed)	1.6	1.8	3.1	-0.8	1.8
Systolic blood pressure, automated reading	0.5	1.4	2.6	-0.5	1.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.3	-0.4
Angina	0.6	0.8	1.1	0.7	-1.0
Medication for hormone replacement therapy	0.3	0.3	0.5	0.3	0.7
Vitamin and mineral supplements	0.3	0.5	0.7	0.5	0.8
Supplements: Zinc	1.3	1.4	2.5	-0.5	1.6
Medication: Co-codamol	0.2	0.2	0.3	-0.5	0.5
Medication: Metformin	0.7	1.0	1.9	0.2	-1.4
Diabetes (father)	4.2	5.2	7.3	1.8	-2.7
Diabetes (mother)	2.7	3.5	6.9	0.3	-2.6
Severe depression (siblings)	0.6	0.7	1.3	-1.1	-0.2
Pack years adult smoking proportion	0.9	1.4	1.9	-1.4	-1.0
Impedance of leg (right)	0.6	2.8	5.3	-0.6	2.3
Leg fat-free mass (left)	0.1	0.5	0.8	0.9	-0.5
Trunk fat percentage	0.0	0.1	0.2	-0.3	-0.4
Hand grip strength (right)	0.5	1.4	2.8	1.7	0.1
Townsend deprivation index at recruitment	0.3	0.5	1.0	-0.1	1.0
Current tobacco smoking	0.3	0.5	0.6	0.6	-0.7
Average weekly fortified wine intake	0.3	0.3	0.4	0.5	0.6
Maternal smoking around birth	1.6	2.4	4.6	0.4	2.1
Fed-up feelings	2.1	3.9	5.6	2.4	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.3	1.5	0.4
Relative age voice broke	0.4	0.6	1.1	0.2	-1.1
Taking other prescription medications	0.4	0.7	1.3	0.1	1.1
Age when periods started (menarche)	0.2	0.6	1.1	1.1	-0.2
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	4.3	-2.1	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.8	-0.5	1.7
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.2	0.0
Qualifications: CSEs or equivalent	0.7	0.9	1.8	1.3	-0.1
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.2	0.7
High blood pressure	0.1	0.2	0.3	-0.2	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.6	-0.8	-0.4
Multivitamins +/- minerals	0.1	0.1	0.2	0.4	-0.3
Stomach or abdominal pain in last month	0.2	0.3	0.5	-0.3	-0.7
Supplements: Glucosamine	0.0	0.1	0.1	-0.2	0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.7	-0.7	-0.8
Medication: Atenolol	0.9	1.2	2.2	1.5	-0.3
Medication: Levothyroxine sodium	0.5	0.9	1.2	-0.7	1.1
Sitting height	0.0	0.2	0.3	0.1	0.6
Chronic bronchitis/emphysema (father)	0.5	0.6	0.8	-0.9	-0.6
High blood pressure (mother)	3.0	4.2	8.4	-0.1	-2.9
Body mass index (BMI)	0.1	0.6	1.2	0.1	-1.1
Impedance of leg (left)	0.3	1.4	1.6	-1.1	1.3
Leg predicted mass (left)	0.1	0.6	0.8	0.9	-0.5
Trunk fat mass	0.0	0.1	0.2	-0.1	-0.4
Waist circumference	0.1	0.3	0.6	0.8	-0.2
Number of incorrect matches in round	1.2	2.1	4.1	-0.2	2.0
Past tobacco smoking	0.4	0.8	1.5	-1.2	0.2
Alcohol usually taken with meals	0.2	0.3	0.6	-0.3	-0.8
Nervous feelings	0.2	0.3	0.4	0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.3	-0.3	1.1
Hearing difficulty/problems with background noise	1.3	2.1	3.3	1.8	0.9
Hair/balding pattern: Pattern 2	0.4	0.5	0.7	0.6	0.8
Had menopause	0.9	1.1	1.4	-1.2	-0.9
Had other major operations	0.2	0.2	0.3	-0.3	-0.5
Forced vital capacity (FVC)	0.1	0.4	0.5	-0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.4	-1.0	1.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	0.2	0.4
Qualifications: None of the above	0.1	0.1	0.2	0.1	-0.5
Financial difficulties in last 2 years	1.4	1.9	2.6	1.1	1.6
Mouth/teeth dental problems	0.1	0.1	0.1	-0.3	0.4
Heart attack	0.2	0.2	0.3	0.6	0.4
Allergy	0.5	1.2	2.3	1.5	-0.4
Pain all over the body in last month	1.3	1.4	2.8	1.7	0.2
Diabetes (self-reported)	1.9	3.0	4.3	1.3	-2.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	0.9	-0.8	0.9
Medication: Ramipril	0.9	1.2	2.1	-1.4	0.5
Medication: Simvastatin	0.3	0.5	0.5	-0.7	0.7
Fluid intelligence score	0.0	0.0	0.0	0.1	-0.1
Illnesses of siblings	0.2	0.3	0.6	0.8	-0.1
Neuroticism score	0.1	0.3	0.5	0.7	0.1
Weight	0.0	0.1	0.2	0.3	-0.5
Impedance of arm (right)	0.1	0.4	0.7	-0.3	0.8
Arm fat percentage (right)	0.0	0.1	0.2	0.0	-0.5
Trunk fat-free mass	0.1	0.3	0.4	0.6	0.5
Hip circumference	0.1	0.4	0.8	0.9	-0.0
Time employed in main current job	0.9	1.1	1.7	-0.7	1.3
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.6	0.0
Father’s age at death	2.0	2.7	5.4	-0.2	-2.3
Worrier / anxious feelings	1.2	2.3	4.5	2.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.1	0.4	0.3
Falls in the last year	0.1	0.1	0.1	-0.4	-0.2
Hair/balding pattern: Pattern 3	0.6	0.9	1.8	0.1	-1.3
Number of live births	0.3	0.5	0.5	0.7	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	-0.1	-0.8
Pulse rate	0.9	1.5	2.6	1.6	0.7
Happiness	0.9	1.1	1.6	-1.3	0.8
Noisy workplace	1.4	1.7	3.1	1.8	0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.5	-1.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.1	1.0	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.4	-0.1
Asthma	1.0	2.0	2.9	-1.7	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.4	0.6	-0.4
Medication: Cholesterol lowering	0.0	0.0	0.0	-0.2	0.1
Depression (self-reported)	0.2	0.3	0.6	-0.8	0.1
Medication: Lansoprazole	3.6	4.1	8.3	0.0	-2.9
Prospective memory result	1.0	1.2	2.1	1.5	-0.5
Lung cancer (father)	1.0	1.2	2.3	0.3	1.5
Illnesses of mother	0.2	0.2	0.4	0.3	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	1.3	1.1	-1.1
Pulse wave Arterial Stiffness index	2.2	2.5	3.1	1.8	-1.4
Impedance of arm (left)	0.1	0.4	0.8	-0.1	0.9
Arm fat mass (right)	0.1	0.2	0.4	0.3	-0.6
Trunk predicted mass	0.1	0.3	0.4	0.7	0.5
Standing height	0.1	0.7	1.3	0.3	1.1
Length of working week for main job	0.9	1.0	1.6	0.7	-1.3
Exposure to tobacco smoke at home	0.4	0.5	0.6	0.6	0.8
Breastfed as a baby	0.8	1.0	1.8	-0.5	-1.4
Tense / ‘highly strung’	0.4	0.6	1.1	-0.4	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.1	1.0	-0.5
Hair/balding pattern: Pattern 4	1.1	2.7	5.4	-0.2	2.3
Birth weight of first child	0.9	1.6	3.1	-1.8	0.2
Peak expiratory flow (PEF)	0.1	0.3	0.4	-0.3	0.7
Pulse wave reflection index	0.1	0.1	0.2	-0.0	0.4
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.3	-0.2	-1.5
Loud music exposure frequency	0.2	0.2	0.4	0.1	-0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.5	0.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.7	-0.2
Blood clot in the leg (DVT)	0.1	0.1	0.3	0.0	0.5
Medication: Paracetamol	0.5	0.9	1.8	1.4	-0.0
Headache pain in last month	0.9	1.6	2.1	-1.1	-1.4
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	-0.2	0.3
Glaucoma (self-reported)	1.2	1.4	2.6	-0.6	1.6
Gout (self-reported)	0.1	0.1	0.1	-0.3	0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	1.3	-1.2	0.9
Medication: Amlodipine	0.8	1.1	1.7	1.3	0.6
Medication: Ventolin 100micrograms inhaler	1.4	1.9	3.5	-0.5	1.9
Birth weight	1.9	4.1	7.8	-0.6	-2.8
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.3	0.6	0.5
High blood pressure (siblings)	0.9	1.3	2.5	-1.6	0.4
Forced vital capacity (FVC), Best measure	0.1	0.2	0.3	0.4	-0.6
Body fat percentage	0.0	0.2	0.3	-0.3	-0.5
Leg fat percentage (right)	0.0	0.0	0.0	0.1	0.2
Arm fat-free mass (right)	0.0	0.2	0.2	0.4	-0.4
Exposure to tobacco smoke outside home	0.6	0.9	1.7	0.2	-1.3
Comparative body size at age 10	1.5	4.2	8.2	0.5	-2.9
Number of full brothers	0.5	0.6	1.0	-0.4	1.0
Worry too long after embarrassment	0.5	0.8	1.1	1.0	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.3	0.6	1.8
Wheeze or whistling in the chest in last year	0.2	0.4	0.6	-0.5	0.8
Number of children fathered	0.1	0.1	0.2	0.2	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.3	0.2	1.1
Age at first live birth	0.4	0.7	1.0	-1.0	0.7
Pulse wave peak to peak time	1.8	2.1	2.5	-1.6	1.3
Health satisfaction	0.1	0.1	0.2	-0.4	-0.2
Shortness of breath walking on level ground	0.7	0.9	1.0	0.9	-1.0
Qualifications: College or University degree	0.2	0.5	0.7	-0.8	-0.6
Eye problems/disorders: None of the above	1.1	1.2	2.4	0.2	1.6
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.3	0.6
Emphysema/chronic bronchitis	0.9	1.0	1.7	0.6	1.3
Medication for pain relief, constipation, heartburn	0.3	0.5	0.5	-0.7	0.7
Neck or shoulder pain in last month	0.3	0.4	0.8	0.9	-0.3
Medication: Blood pressure	0.0	0.0	0.0	-0.1	0.2
Angina (self-reported)	0.7	0.9	1.3	0.7	-1.1
Migraine (self-reported)	0.5	0.6	1.0	1.0	-0.5
Medication: Ibuprofen	0.2	0.2	0.3	0.5	-0.4
Medication: Allopurinol	0.1	0.2	0.3	-0.5	-0.1
Medication: Omeprazole	0.2	0.3	0.3	-0.5	0.5
Medication: Seretide 50 evohaler	2.3	2.7	5.0	-0.6	2.2
Mean time to correctly identify matches	0.4	0.8	1.6	-0.3	1.3
Heart disease (mother)	0.1	0.1	0.1	-0.3	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.4	0.8	1.2
Whole body fat mass	0.0	0.2	0.3	-0.0	-0.6
Leg fat mass (right)	0.0	0.1	0.1	0.2	-0.3
Arm predicted mass (right)	0.0	0.2	0.2	0.4	-0.4
Pulse rate, automated reading	2.8	9.1	16.8	4.1	-1.1
Alcohol intake frequency.	0.6	1.4	1.4	-1.2	-1.1
Comparative height size at age 10	0.2	1.0	1.8	0.4	1.3
Number of full sisters	0.1	0.1	0.2	-0.1	0.4
Suffer from ‘nerves’	0.1	0.2	0.2	-0.5	0.4
Overall health rating	0.7	1.6	2.4	1.5	-0.9
Chest pain or discomfort	0.3	0.4	0.8	-0.4	0.9
Had major operations	0.0	0.0	0.1	-0.2	0.2
Age at last live birth	0.1	0.2	0.3	-0.3	0.5
Family relationship satisfaction	0.2	0.2	0.3	-0.4	0.5
Leg pain on walking	0.1	0.1	0.1	-0.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.8	0.9	0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	0.0	1.1
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	3.7	-1.9	0.3
Medication: Aspirin	0.0	0.0	0.0	-0.1	0.2
Supplements: Vitamin C	0.1	0.1	0.1	-0.4	-0.2
Knee pain experienced in last month	0.2	0.4	0.5	0.7	0.5
Hypertension (Self-reported)	0.1	0.3	0.5	-0.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.4	-0.4
Illnesses of father: Heart disease	0.2	0.2	0.2	-0.5	-0.4
Illnesses of siblings: Diabetes	1.0	1.2	2.0	1.4	-0.7
Smoking status: Previous	0.4	0.5	1.0	1.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	-0.8	0.1
Whole body fat-free mass	0.0	0.2	0.4	0.7	-0.0
Leg fat-free mass (right)	0.1	0.6	0.9	0.4	-1.0
Arm fat percentage (left)	0.0	0.1	0.2	0.3	-0.5
Average weekly red wine intake	0.5	0.7	0.8	0.8	-0.9
Handedness (chirality/laterality): Left-handed	1.7	2.1	4.1	-0.2	2.0
Mood swings	0.2	0.3	0.6	0.3	0.8
Loneliness, isolation	0.0	0.1	0.1	0.2	0.3
Long-standing illness, disability or infirmity	0.0	0.0	0.1	0.1	-0.3
Ever had bowel cancer screening	0.7	0.8	1.3	-1.2	0.5
Diabetes diagnosed by doctor	2.4	3.9	6.0	1.3	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.8	1.3	0.2
Friendships satisfaction	0.3	0.4	0.5	0.7	-0.5
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.5	-0.0
Commuting to job workplace: Walk	0.0	0.0	0.1	0.3	-0.2
Eye problems/disorders: Cataract	2.0	2.3	4.5	0.3	-2.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.6	0.5	-0.7
Medication for cholesterol	1.4	2.2	4.3	-0.2	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	0.9	-1.0	-0.5
Back pain experienced in last month	0.6	0.9	1.6	-1.3	0.3
Mineral and other dietary supplements	0.4	0.5	0.6	0.7	-0.7
Breast cancer (self-reported)	3.6	4.3	7.8	2.8	0.9
Asthma (self-reported)	1.1	2.2	3.2	-1.8	1.1
Osteoporosis (self-reported)	0.0	0.1	0.1	0.3	-0.1
Osteoarthritis (self-reported)	0.2	0.3	0.4	-0.4	-0.6
Medication: Aspirin	0.1	0.1	0.2	-0.1	0.4
Medication: Gliclazide	0.1	0.1	0.2	-0.4	0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	1.1	1.1	0.8
Smoking status: Current	0.6	0.9	1.3	0.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.8	0.9	-0.6
Whole body water mass	0.0	0.2	0.4	0.7	-0.0
Leg predicted mass (right)	0.1	0.5	0.8	0.4	-0.9
Arm fat mass (left)	0.1	0.4	0.6	0.3	-0.8
Number of self-reported non-cancer illnesses	1.2	2.1	3.8	0.5	1.9
Average weekly champagne plus white wine intake	1.0	1.3	1.7	-1.3	-1.0
Miserableness	0.2	0.3	0.7	0.8	0.1
Guilty feelings	0.3	0.5	1.0	-0.0	1.0
Wears glasses or contact lenses	0.1	0.1	0.1	-0.1	-0.4
Ever taken oral contraceptive pill	0.7	0.8	1.5	0.2	1.2
Hearing aid user	0.6	0.7	1.4	0.3	-1.2
Mother’s age at death	0.1	0.1	0.2	-0.3	0.5
Financial situation satisfaction	1.4	1.8	3.1	-0.7	1.8
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.1	0.7
Commuting to job workplace: Public transport	1.6	1.9	3.8	-0.2	-1.9
Eye problems/disorders: Glaucoma	0.3	0.4	0.4	0.6	0.7
Medication: Blood pressure	0.3	0.5	0.9	-0.4	0.9
Pain type(s) experienced in last month: Hip pain	1.4	1.8	2.0	-1.4	1.3
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	0.3	-0.2
High cholesterol (Self-reported)	0.7	1.2	1.8	1.3	0.8
Medication: Bendroflumethiazide	0.1	0.2	0.2	-0.5	-0.3
Medication: Paracetamol	0.0	0.0	0.0	0.2	-0.1
Medication: Lisinopril	0.9	1.1	1.8	1.4	-0.6
Medication: Atorvastatin	2.2	2.8	3.5	1.9	1.4
Illnesses of father: High blood pressure	0.4	0.5	0.9	-1.0	-0.2
Alcohol drinker status: Never	2.0	2.4	4.8	-2.2	-0.0
Ever smoked	0.5	0.8	1.5	1.2	-0.3
Basal metabolic rate	0.0	0.2	0.4	0.6	-0.3
Leg fat percentage (left)	0.0	0.2	0.2	-0.3	-0.5
Arm fat-free mass (left)	0.0	0.2	0.3	0.4	-0.5
Number of operations (self-reported)	1.1	1.6	2.7	0.7	-1.7
Average weekly beer plus cider intake	1.5	2.2	3.0	-1.2	1.7
Irritability	0.2	0.3	0.4	0.6	-0.5
Risk taking	0.5	0.7	1.2	-0.4	1.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.5	0.1
Fractured/broken bones in last 5 years	1.7	2.2	4.0	-0.7	-2.0
Age started oral contraceptive pill	0.2	0.3	0.5	-0.3	0.7
Diastolic blood pressure, automated reading	1.1	3.3	6.2	0.6	2.5
Ever depressed for a whole week	0.2	0.2	0.4	0.6	0.0
Unable to work because of sickness or disability	0.4	0.5	1.0	1.0	0.1
Commuting to job workplace: Cycle	2.2	2.7	5.3	-2.3	0.2
Myopia	0.2	0.3	0.7	0.8	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	0.0	-0.6
Cholesterol lowering medication	0.5	0.7	0.9	0.8	0.9
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	-0.3	0.3
Pain experienced in last month	0.5	0.8	1.3	-0.6	1.2
Supplements: Calcium	0.4	0.5	0.6	-0.8	0.6
Basal cell carcinoma (self-reported)	0.5	0.5	0.6	0.7	0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.3	0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	0.5	0.7
Heart disease (siblings)	0.6	0.7	0.9	0.7	1.0
Alcohol drinker status: Previous	1.7	1.9	3.7	-0.3	1.9
Pack years of smoking	1.2	1.8	2.8	-1.7	-0.9
Impedance of whole body	0.1	0.8	1.2	-0.6	1.1
Leg fat mass (left)	0.1	0.4	0.7	0.0	-0.9
Arm predicted mass (left)	0.0	0.1	0.2	0.4	-0.2