Hub : Genes

PDCD4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1420	0.0510	0.00450	0.051	NA	0.012	NA	0.021	1.0e-04	NA	3.8e-02	NA	9.5e-03
2	GTEx	Nerve Tibial	0.1071	0.0478	0.00870	0.001	NA	0.019	NA	-0.004	2.9e-01	NA	1.6e-02	NA	8.0e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.0956	0.0280	0.00015	0.002	0.029	0.047	0.031	0.038	1.6e-01	1.1e-04	9.7e-07	5.8e-05	9.4e-06
4	YFS	Blood	0.2516	0.0291	0.00000	0.228	0.306	0.326	0.313	0.324	4.3e-73	1.6e-102	3.3e-110	2.9e-105	2.2e-109
5	TCGA	Liver Hepatocellular Carcinoma	0.1510	0.0710	0.00460	-0.001	0.025	0.008	NA	0.008	3.7e-01	2.3e-02	1.3e-01	NA	1.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.3	2.1	4.6	0.5	-1.8	-0.6	2.2	-1.4
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	0.0	-0.6	-0.0	0.4	0.3
Depressed Affect (Nagel 2018)	0.3	0.5	1.8	-0.8	1.4	-0.1	-0.1	0.5
Depression (Nagel 2018)	0.3	0.5	1.3	-0.2	1.1	-0.2	-0.8	0.7
Intelligence (Savage-Jansen 2018)	0.6	1.8	6.2	-0.8	2.5	1.1	-1.0	-0.1
Neuroticism (Nagel 2018)	0.1	0.3	1.0	-0.7	1.0	-0.2	0.1	0.2
Schizophrenia (2018)	0.4	0.9	2.4	-0.3	0.7	0.5	-1.2	1.5
Schizophrenia vs Biploar Disorder	1.5	1.9	5.7	0.4	1.4	0.8	-1.1	2.4
Worry (Nagel 2018)	0.2	0.4	0.9	0.8	0.1	0.0	0.9	0.7
Alzheimer’s Disease (in mother)	0.6	0.7	1.2	0.8	0.3	-0.9	1.1	-0.6
Alzheimer’s Disease (in father)	1.2	1.3	2.5	-0.4	-1.6	-1.2	0.4	-1.5
Alzheimer’s Disease (including proxy)	1.5	2.2	4.0	0.6	-1.2	-1.8	2.0	-1.4
Crohns Disease (2017)	0.1	0.3	0.6	-0.4	0.5	0.5	-0.8	0.1
Irritable Bowel Disease (IBD)	0.5	1.1	2.5	-1.0	1.2	0.3	-1.6	0.7
Ulcerative Colitis (UC)	1.1	2.1	5.6	-1.5	1.6	0.1	-2.4	0.6
Major Depression (MDD)	0.4	0.5	0.7	-0.7	-0.8	-0.9	0.0	0.8
Reaction Time	0.8	1.5	3.2	-0.4	-1.8	-1.2	1.5	-0.6
Verbal and Numeric Reasoning (VNR)	1.2	2.9	6.9	-0.3	2.6	1.0	-2.5	0.4
Breast Cancer	0.1	0.3	1.2	-0.0	-0.6	0.1	-0.1	1.1
Ovarian Cancer	0.8	1.0	2.4	-0.9	0.3	0.2	-1.5	1.2
Prostate Cancer	0.9	1.2	2.4	-1.5	1.1	0.3	-1.5	0.5
Age at First Birth	0.3	0.5	1.9	-0.5	1.4	-0.2	-0.5	0.0
Bipolar Disorder (2011)	0.5	0.5	1.6	0.2	-1.3	-0.3	0.9	0.1
Body Mass Index (BMI) (2010)	1.0	1.4	4.4	-1.5	-2.1	-0.2	-0.7	-0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.3	-1.2	0.7	0.2	-0.4	-0.5
Crohns Disease (2012)	0.3	0.5	2.3	0.1	-0.3	-1.5	0.1	-0.5
Mean Putamen Volume	0.6	0.7	1.8	-0.8	-1.4	-0.5	-0.6	-0.5
Fasting Glucose	0.9	1.1	2.4	-1.2	1.5	0.2	-1.4	0.1
HbA1C	1.2	1.4	2.5	-1.4	-1.4	-0.6	-0.1	-1.6
HDL Cholesterol	1.3	2.2	3.8	1.2	-2.0	-0.8	1.4	-1.7
LDL Cholesterol	0.3	0.4	1.2	0.5	0.4	1.1	0.7	-0.1
Lupus	1.4	2.1	5.3	0.3	2.3	1.4	-0.3	1.8
Neuroticism (2016)	0.3	0.5	1.6	0.3	0.5	0.7	-0.1	1.2
Primary Biliary Cirrhosis	0.3	0.5	1.3	-0.5	1.2	0.9	-0.2	0.2
Rheumatoid Arthritis	0.4	0.6	1.8	0.3	-0.4	0.1	0.9	1.3
Schizophrenia (2014)	0.4	0.8	1.4	1.1	1.2	0.6	-0.2	1.0
Triglycerides	0.3	0.5	1.6	0.2	0.4	0.7	-0.6	1.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.5	-1.0	1.1	-0.8	-1.9	-0.1
Ulcerative Colitis	0.6	0.9	2.2	-0.3	1.1	-0.7	-1.5	0.7
Blood Eosinophil Count	0.2	1.6	2.9	1.5	-1.2	-1.2	1.7	0.4
Blood Platelet Count	0.1	0.9	2.4	-1.6	0.6	-0.2	-1.2	0.5
Blood Red Count	0.4	3.5	6.5	-0.9	-2.5	-1.7	2.3	-1.3
Blood White Count	0.1	0.4	1.3	0.5	0.3	-0.5	-0.5	1.1
Heel T-Score	0.5	3.9	12.6	2.5	-0.5	0.6	3.5	0.6
BMI	0.2	1.0	3.1	-1.1	-0.5	-0.1	-1.8	0.6
Height	0.0	0.5	1.0	-0.8	-0.2	-0.3	0.8	-1.0
Waist Hip Ratio (WHR)	0.2	0.9	3.2	0.3	-0.6	1.8	-0.3	0.8
Systolic Blood Pressure	0.6	3.1	9.7	3.1	-0.1	1.4	1.5	1.1
Smoking Status	0.1	0.3	0.7	-0.6	-0.4	-0.2	0.8	0.7
Allergy or Eczema	0.3	0.8	2.9	-0.4	0.2	1.7	0.9	-0.1
Cardiovascular Disease	0.6	2.1	5.0	1.3	-2.2	-1.3	1.4	-0.1
Hypothyroidism (self reported)	0.5	1.3	3.2	0.5	-0.6	1.5	1.8	-0.5
Respiratory disease	1.0	2.3	5.8	1.9	-0.5	0.9	2.4	1.1
Type 2 Diabetes (T2D) (2018)	2.0	3.7	9.4	-2.5	3.1	1.7	-0.3	-0.5
Lung FEV1/FVC ratio	0.3	1.8	4.2	1.0	-2.0	-1.8	0.6	-0.1
Lung FVC	0.2	1.2	4.4	-2.1	-0.3	-0.2	-1.0	-0.5
Neuroticism	0.5	1.2	4.4	-0.4	2.1	1.1	-0.3	0.2
Chronotype (morning person)	0.5	1.0	2.9	1.4	1.7	-0.1	-0.4	-0.5
Hair Pigment	0.4	11.8	27.0	4.0	-1.7	0.7	5.2	-3.6
Tanning	0.1	1.3	3.5	0.6	-1.7	-0.2	-0.2	1.9
Hand grip strength (left)	1.1	2.8	8.0	-0.4	-0.9	1.0	2.0	-2.8
Number of treatments/medications taken	0.9	1.6	3.2	-0.4	-1.2	-1.8	1.6	-0.5
Average weekly spirits intake	0.6	0.7	1.8	0.3	0.1	-1.3	1.2	0.3
Sensitivity / hurt feelings	1.5	2.6	6.8	-2.6	0.3	1.4	-1.6	-1.2
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.7	-0.2	1.3	1.3	-1.1	1.3
Hearing difficulty/problems: Yes	0.3	0.4	1.1	-0.3	0.0	-0.9	-0.4	-1.0
Relative age of first facial hair	0.1	0.1	0.3	-0.2	0.6	-0.3	-0.4	-0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.5	0.1	-0.2	-1.2	-0.8	1.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	-0.2	-0.6	-1.1	-0.7	-1.0
Ever had hysterectomy (womb removed)	1.4	1.6	3.0	0.5	-1.4	-1.7	0.7	-1.5
Systolic blood pressure, automated reading	0.7	1.9	7.1	2.7	0.5	0.3	-0.2	1.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.2	-0.9	1.0	1.0	-0.2	-1.1
Angina	0.6	0.8	2.8	-0.3	-1.0	-1.7	-0.1	-0.0
Medication for hormone replacement therapy	0.4	0.4	1.3	0.2	-0.7	-0.5	1.1	0.1
Vitamin and mineral supplements	0.5	0.7	2.2	0.5	-0.6	-0.4	0.7	-1.5
Supplements: Zinc	1.3	1.4	3.2	0.7	-0.3	-1.8	1.6	-0.8
Medication: Co-codamol	0.9	1.1	3.3	-0.9	0.9	1.8	0.5	-0.5
Medication: Metformin	1.7	2.5	7.4	-0.1	2.7	2.1	-0.2	0.7
Diabetes (father)	1.7	2.1	4.8	-1.0	2.1	0.7	-2.2	0.1
Diabetes (mother)	2.6	3.3	6.9	-2.6	2.2	1.8	-1.0	-0.6
Severe depression (siblings)	0.6	0.6	1.1	-1.0	0.3	0.7	-1.1	0.5
Pack years adult smoking proportion	0.3	0.5	1.4	0.2	-0.1	-1.0	-1.2	-0.2
Impedance of leg (right)	0.3	1.3	5.2	0.3	-0.0	-0.4	2.3	-1.0
Leg fat-free mass (left)	0.1	0.7	0.9	-0.8	0.5	0.8	-0.9	-0.9
Trunk fat percentage	0.4	1.7	3.8	-1.1	2.0	-0.1	-1.8	-0.6
Hand grip strength (right)	0.5	1.3	3.9	-0.6	1.1	0.9	0.6	-2.0
Townsend deprivation index at recruitment	0.3	0.4	1.2	-0.4	-0.1	1.1	0.8	0.2
Current tobacco smoking	0.3	0.5	1.8	-0.6	1.4	-0.1	0.4	-0.2
Average weekly fortified wine intake	0.3	0.4	1.2	-0.5	-0.2	-1.1	0.0	-0.6
Maternal smoking around birth	1.8	2.7	4.8	1.8	0.1	1.6	2.2	-1.7
Fed-up feelings	0.7	1.3	4.6	-1.0	0.5	0.3	-2.1	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	-0.6	0.2	-0.3	-0.4	-0.7
Relative age voice broke	0.3	0.4	1.1	-0.5	0.3	0.2	-1.0	0.7
Taking other prescription medications	0.7	1.1	2.1	0.1	-1.4	-1.4	1.1	-0.5
Age when periods started (menarche)	0.7	1.7	4.6	-2.1	-0.6	-0.4	0.8	-1.6
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	6.7	-1.0	-0.1	-1.0	0.3	-2.6
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	7.2	1.6	-0.3	1.2	2.7	0.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.3	-0.1	0.6	0.1	-0.3
Qualifications: CSEs or equivalent	0.3	0.3	1.4	-0.2	-0.6	0.1	-0.0	1.2
Serious illness, injury or assault to yourself	0.5	0.6	1.0	0.5	0.8	-1.0	1.0	0.2
High blood pressure	0.4	1.1	3.2	1.2	-1.1	-0.2	0.2	1.8
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.6	0.3	1.2	1.9	0.5	0.3
Multivitamins +/- minerals	0.1	0.2	0.4	-0.5	0.3	-0.4	0.1	0.6
Stomach or abdominal pain in last month	0.9	1.1	2.5	0.7	1.6	0.8	-1.2	0.7
Supplements: Glucosamine	0.6	0.8	2.0	1.4	-0.9	-0.9	-0.2	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.0	-0.6	-0.1	-0.9	-1.0	0.0
Medication: Atenolol	0.2	0.2	0.9	0.4	-0.2	-1.0	-0.2	0.1
Medication: Levothyroxine sodium	0.5	0.8	3.0	-0.3	0.7	0.5	1.7	-0.2
Sitting height	0.0	0.3	1.4	0.1	-0.3	1.2	0.1	-0.0
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	-0.9	-0.8	0.1	0.2	0.5
High blood pressure (mother)	3.7	5.2	8.7	-1.8	2.2	2.9	-2.4	1.8
Body mass index (BMI)	0.2	0.8	2.9	-0.5	0.7	-0.5	-1.7	0.5
Impedance of leg (left)	0.1	0.5	1.9	-0.4	0.0	-0.4	1.4	-0.1
Leg predicted mass (left)	0.1	0.6	0.8	-0.7	0.5	0.9	-0.9	-0.8
Trunk fat mass	0.4	1.5	3.4	-0.8	1.9	0.2	-1.8	-0.5
Waist circumference	0.1	0.4	1.7	0.2	0.6	0.1	-1.3	0.0
Number of incorrect matches in round	0.4	0.7	1.9	1.4	-0.3	-1.0	0.8	-0.1
Past tobacco smoking	0.9	1.6	3.5	-0.1	1.9	0.3	-1.4	-1.5
Alcohol usually taken with meals	0.6	0.9	1.8	1.0	0.7	0.1	-1.4	1.1
Nervous feelings	0.2	0.3	1.0	0.2	0.5	1.0	0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.9	1.1	1.4	0.2	0.3	-0.5
Hearing difficulty/problems with background noise	1.2	1.8	7.3	-0.3	1.2	-0.3	0.6	-2.7
Hair/balding pattern: Pattern 2	0.4	0.6	1.8	1.3	0.1	0.0	0.9	0.4
Had menopause	0.7	0.9	3.3	0.8	-0.1	-0.9	-0.0	1.8
Had other major operations	0.6	0.7	2.1	0.6	0.5	-0.1	0.8	1.5
Forced vital capacity (FVC)	0.3	1.3	3.7	-1.9	0.2	1.1	0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.7	0.7	-0.9	1.0	1.9	-0.4
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.9	0.7	0.3	0.6	1.4	1.4
Qualifications: None of the above	0.7	1.5	4.4	-1.1	-0.5	-2.1	0.1	-1.2
Financial difficulties in last 2 years	0.8	1.1	2.2	1.0	-1.5	0.7	1.3	-0.4
Mouth/teeth dental problems	1.1	1.7	3.0	1.7	-1.4	0.9	-0.7	1.4
Heart attack	0.6	0.8	2.5	0.8	-0.5	-1.6	0.7	-0.2
Allergy	0.3	0.7	1.6	-0.6	-0.3	-1.2	-1.2	-0.2
Pain all over the body in last month	1.0	1.1	3.0	-0.5	-0.6	-1.7	0.1	-1.3
Diabetes (self-reported)	1.5	2.3	6.6	-2.1	2.6	0.4	-0.3	-0.6
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.1	0.3	-1.2	1.3	2.0	-0.9
Medication: Ramipril	0.4	0.5	1.4	1.2	-0.8	-0.1	0.5	0.5
Medication: Simvastatin	0.1	0.1	0.3	-0.3	0.1	-0.6	-0.3	-0.4
Fluid intelligence score	0.7	1.5	3.9	0.2	2.0	1.3	-1.3	0.6
Illnesses of siblings	0.2	0.3	0.8	0.0	-0.8	-0.2	0.9	0.2
Neuroticism score	0.8	1.8	4.6	-0.2	1.9	2.1	-0.2	0.6
Weight	0.1	0.6	1.9	-0.6	0.7	-0.1	-1.4	-0.4
Impedance of arm (right)	0.1	0.3	0.4	-0.6	0.7	0.4	0.0	-0.6
Arm fat percentage (right)	0.3	1.0	3.2	-0.1	1.3	-0.1	-1.8	0.2
Trunk fat-free mass	0.0	0.3	0.7	0.3	-0.5	0.5	0.0	-0.8
Hip circumference	0.2	0.8	2.1	-0.4	1.0	-0.4	-1.5	-0.7
Time employed in main current job	2.1	2.4	4.1	-1.7	-2.0	-1.0	1.1	-1.7
Alcohol intake versus 10 years previously	1.0	1.5	3.6	0.2	1.4	1.9	-1.2	0.4
Father’s age at death	1.2	1.6	4.9	-0.6	1.4	0.2	-2.2	1.0
Worrier / anxious feelings	0.2	0.5	1.9	-0.2	0.4	1.4	0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.0	-0.8	1.4	0.2	-0.8	-0.7
Falls in the last year	0.1	0.2	0.4	-0.5	-0.7	0.0	0.1	0.4
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	-0.1	-0.2	0.5	-1.2	0.7
Number of live births	1.0	1.4	3.5	-0.4	0.6	1.6	0.3	1.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.7	-1.6	-0.1	0.6	-0.0	-0.9
Pulse rate	0.5	0.8	2.2	-0.3	-1.5	-1.2	-0.6	0.4
Happiness	0.3	0.3	0.8	-0.9	0.4	-0.3	0.1	-0.8
Noisy workplace	1.0	1.2	2.4	-0.7	1.5	0.5	1.3	-1.1
Qualifications: A levels/AS levels or equivalent	1.6	3.5	8.2	2.1	1.7	2.9	-0.3	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.5	-1.2	-0.4	0.3	0.5	-0.0
Mouth/teeth dental problems: Dentures	0.3	0.6	0.9	-0.8	0.9	-0.9	0.5	-0.4
Asthma	0.7	1.3	2.6	1.2	-1.0	0.3	1.6	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.1	-0.5	1.5	0.0	0.2	-0.0
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.5	0.5	0.0	0.3	-0.0
Depression (self-reported)	0.0	0.1	0.1	0.4	0.3	0.0	-0.2	-0.0
Medication: Lansoprazole	3.2	3.6	9.7	-1.8	1.0	1.7	-3.1	1.1
Prospective memory result	0.4	0.5	1.1	-0.7	1.0	-0.4	-0.9	-0.2
Lung cancer (father)	0.5	0.6	2.1	0.0	0.0	-1.5	0.8	-0.5
Illnesses of mother	1.0	1.2	3.7	0.2	-1.1	-1.9	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	4.4	-2.1	-0.0	0.4	-0.1	-0.6
Pulse wave Arterial Stiffness index	1.0	1.2	3.9	0.5	0.7	-0.3	-1.1	2.0
Impedance of arm (left)	0.1	0.5	1.2	-1.1	0.7	0.4	0.1	-0.8
Arm fat mass (right)	0.3	1.2	4.3	-0.4	1.2	0.1	-2.1	-0.1
Trunk predicted mass	0.0	0.3	0.8	0.3	-0.5	0.5	-0.0	-0.9
Standing height	0.1	0.8	2.7	-0.5	0.0	0.8	0.3	-1.6
Length of working week for main job	0.5	0.5	1.8	-0.3	0.1	0.4	-0.7	1.3
Exposure to tobacco smoke at home	0.7	0.8	1.3	1.1	-0.7	-0.7	1.2	0.5
Breastfed as a baby	0.8	1.0	2.5	-0.1	1.5	-0.0	-1.6	-0.1
Tense / ‘highly strung’	1.1	1.9	4.2	2.0	2.0	0.9	0.7	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.8	8.3	0.2	2.9	-0.1	-0.2	0.6
Hair/balding pattern: Pattern 4	0.6	1.3	2.7	1.6	-0.2	-0.0	1.6	-1.1
Birth weight of first child	1.9	3.4	6.1	-2.1	2.5	1.8	-0.7	-1.7
Peak expiratory flow (PEF)	0.5	1.1	3.0	0.2	-1.5	0.2	1.7	-0.2
Pulse wave reflection index	0.5	0.6	1.4	0.8	-0.0	-0.9	0.4	1.2
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.9	-0.9	0.4	1.4	-1.7	1.3
Loud music exposure frequency	0.4	0.5	1.8	0.4	0.4	1.4	0.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.7	0.6	-0.2	1.3	-0.4	0.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.2	-1.5	-0.6	-0.7	0.2	-0.5
Blood clot in the leg (DVT)	0.7	0.9	3.3	0.0	1.8	0.7	-0.6	-0.4
Medication: Paracetamol	0.3	0.5	1.3	-0.9	0.6	-1.1	0.4	0.2
Headache pain in last month	1.0	1.7	4.6	-2.1	1.6	0.4	-0.7	-0.9
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.4	0.7	-0.0	-0.1	0.2	0.0
Glaucoma (self-reported)	0.6	0.7	1.8	-0.1	-0.3	-0.0	1.2	-1.4
Gout (self-reported)	0.1	0.1	0.4	-0.1	-0.6	-0.1	0.4	-0.4
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.3	-0.2	-0.1	1.4	1.5	-0.7
Medication: Amlodipine	1.0	1.5	2.7	0.6	1.6	1.7	-1.1	0.8
Medication: Ventolin 100micrograms inhaler	1.1	1.5	5.1	0.9	-0.3	1.0	2.3	0.4
Birth weight	1.2	2.5	4.5	-1.7	1.7	1.2	-2.1	1.0
Chronic bronchitis/emphysema (mother)	0.6	0.8	2.0	0.2	0.6	1.4	1.0	0.6
High blood pressure (siblings)	0.6	0.9	2.3	0.2	1.5	1.3	-0.6	0.3
Forced vital capacity (FVC), Best measure	0.3	1.2	4.0	-2.0	0.1	0.7	0.6	-1.1
Body fat percentage	0.3	1.3	3.0	-0.8	1.7	-0.1	-1.6	-0.2
Leg fat percentage (right)	0.2	0.7	1.7	-0.6	1.3	-0.8	-0.7	-0.3
Arm fat-free mass (right)	0.0	0.1	0.3	-0.5	-0.1	0.2	-0.5	-0.4
Exposure to tobacco smoke outside home	0.6	0.8	3.0	-1.7	-0.5	0.2	0.1	0.7
Comparative body size at age 10	0.9	2.4	6.0	0.2	0.4	0.7	-2.5	2.3
Number of full brothers	0.8	1.0	2.0	0.3	-0.9	-1.4	1.4	-0.4
Worry too long after embarrassment	0.1	0.2	0.5	0.0	0.6	0.7	-0.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.9	2.0	0.7	0.0	0.2	-0.5
Wheeze or whistling in the chest in last year	0.1	0.1	0.6	0.0	-0.2	-0.2	0.8	0.2
Number of children fathered	0.1	0.1	0.2	0.2	-0.2	-0.5	-0.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.3	0.8	0.9	0.6	1.8	-0.4
Age at first live birth	0.3	0.5	1.4	-0.1	1.2	0.5	-0.9	0.4
Pulse wave peak to peak time	0.9	1.0	3.3	-0.3	-0.6	0.5	1.1	-1.8
Health satisfaction	0.3	0.3	0.5	-0.7	-0.4	-0.5	0.4	0.7
Shortness of breath walking on level ground	0.5	0.6	1.2	-1.1	0.8	0.4	-0.9	-0.0
Qualifications: College or University degree	0.3	0.9	1.6	-0.1	1.2	1.3	-1.1	0.5
Eye problems/disorders: None of the above	0.9	1.1	3.6	0.6	-0.7	-0.1	1.9	-0.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.6	-0.9	-0.1	-1.0	1.3	-0.9
Emphysema/chronic bronchitis	0.9	1.0	2.8	1.3	0.1	-0.5	1.7	0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.4	0.8	-0.7	1.2	-0.2	-0.8
Neck or shoulder pain in last month	1.0	1.5	4.2	-1.0	2.0	1.2	0.1	-0.8
Medication: Blood pressure	0.1	0.2	0.4	-0.1	-0.7	0.5	-0.4	0.4
Angina (self-reported)	0.8	1.0	3.8	-0.3	-1.1	-1.9	-0.2	-0.0
Migraine (self-reported)	0.1	0.1	0.2	0.2	0.0	0.3	-0.4	-0.1
Medication: Ibuprofen	0.9	1.1	5.4	-0.2	2.3	-0.2	0.2	0.2
Medication: Allopurinol	0.2	0.3	0.7	0.1	-0.6	-0.9	-0.7	-0.2
Medication: Omeprazole	1.3	1.6	3.6	-1.9	-1.4	-1.4	0.0	-0.5
Medication: Seretide 50 evohaler	3.1	3.5	8.7	1.3	-2.5	0.8	3.0	0.7
Mean time to correctly identify matches	1.1	2.1	4.0	-0.3	-1.6	-1.6	2.0	-1.2
Heart disease (mother)	0.2	0.2	0.6	0.8	0.2	0.1	0.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.0	1.4	0.6	0.7	1.2	0.5
Whole body fat mass	0.3	1.3	3.4	-0.8	1.5	0.2	-1.8	-0.3
Leg fat mass (right)	0.2	0.9	1.9	-0.9	1.4	-0.1	-1.2	-0.5
Arm predicted mass (right)	0.0	0.1	0.2	-0.3	-0.2	0.3	-0.4	-0.3
Pulse rate, automated reading	0.7	2.4	6.3	-2.0	-0.6	-0.9	-2.5	-0.7
Alcohol intake frequency.	0.9	2.1	3.1	-1.5	-1.2	-1.8	-1.4	-1.3
Comparative height size at age 10	0.2	1.3	3.5	-0.2	-0.7	-1.9	0.1	-1.5
Number of full sisters	0.4	0.4	1.0	0.4	0.1	1.0	-1.0	0.4
Suffer from ‘nerves’	0.8	1.3	2.2	1.5	1.4	0.8	0.5	1.2
Overall health rating	0.3	0.7	1.4	-0.5	0.9	-1.2	-0.8	0.2
Chest pain or discomfort	0.5	0.7	1.8	-1.3	0.3	-0.4	0.5	-1.1
Had major operations	0.7	0.8	2.1	1.3	-0.5	-0.0	0.5	1.4
Age at last live birth	0.5	0.7	1.7	-0.7	1.3	1.1	-0.4	-0.4
Family relationship satisfaction	0.6	0.7	2.3	-0.2	1.0	0.5	1.5	-0.2
Leg pain on walking	0.1	0.1	0.2	0.1	-0.1	0.5	-0.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	0.3	0.6	1.1	0.1	0.6
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.6	1.6	0.7	-0.1	0.8	0.7
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.0	0.7	1.4	-1.4	-1.0	-0.3
Medication: Aspirin	0.5	0.6	1.9	0.3	-0.1	-1.4	0.8	0.7
Supplements: Vitamin C	0.7	0.8	1.7	0.0	1.0	0.4	-1.0	1.3
Knee pain experienced in last month	0.4	0.6	1.9	-0.5	0.3	-0.7	0.3	-1.4
Hypertension (Self-reported)	0.5	1.4	2.6	1.4	-1.6	-0.4	0.5	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.1	0.1	-0.5	-1.0	-1.8	-0.6
Illnesses of father: Heart disease	0.1	0.2	0.5	0.5	0.2	0.1	-0.2	0.7
Illnesses of siblings: Diabetes	0.3	0.4	0.9	-0.8	0.4	1.0	-0.3	0.2
Smoking status: Previous	0.6	0.8	2.0	0.1	-1.4	-0.3	0.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.5	-1.7	0.0	1.9	0.1	-0.0
Whole body fat-free mass	0.0	0.2	0.5	-0.1	-0.2	0.7	-0.3	-0.7
Leg fat-free mass (right)	0.1	0.7	1.6	-0.9	0.3	0.9	-1.3	-0.4
Arm fat percentage (left)	0.2	1.0	3.0	-0.4	1.3	-0.1	-1.7	0.2
Average weekly red wine intake	0.9	1.4	5.2	0.3	0.9	0.7	-0.6	2.3
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.8	0.6	-1.7	0.3	1.1	0.1
Mood swings	0.0	0.1	0.1	-0.3	0.3	0.2	-0.0	0.2
Loneliness, isolation	0.6	0.8	1.7	-1.0	1.3	0.2	-0.7	-0.9
Long-standing illness, disability or infirmity	1.0	1.5	5.8	0.3	2.4	-0.5	1.2	0.2
Ever had bowel cancer screening	5.4	6.3	17.9	1.4	4.2	3.3	-0.7	0.3
Diabetes diagnosed by doctor	2.2	3.7	10.0	-2.4	3.2	1.5	-0.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	-0.7	0.0	1.1	0.1	1.0
Friendships satisfaction	0.3	0.3	0.6	-0.8	0.5	-0.2	0.4	0.8
Qualifications: nursing, teaching	0.3	0.5	1.4	0.4	1.2	-0.1	-0.5	0.9
Commuting to job workplace: Walk	1.0	1.1	2.1	-1.4	-1.1	0.1	-0.4	-1.4
Eye problems/disorders: Cataract	1.1	1.3	2.9	-0.8	-0.3	-0.3	-1.7	1.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	-0.6	1.1	0.4	-0.8	-0.2
Medication for cholesterol	2.1	3.1	5.0	-1.5	2.1	2.0	-2.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	0.8	0.2	-1.0	-0.6	0.9
Back pain experienced in last month	0.2	0.2	0.9	-0.4	1.0	0.2	0.1	0.0
Mineral and other dietary supplements	0.0	0.0	0.1	-0.1	0.0	0.3	-0.3	0.0
Breast cancer (self-reported)	0.5	0.5	1.3	0.3	-0.1	-1.0	1.1	0.6
Asthma (self-reported)	0.6	1.2	2.3	1.2	-1.0	0.4	1.5	0.9
Osteoporosis (self-reported)	0.3	0.4	1.6	-1.3	0.3	0.2	-0.4	0.3
Osteoarthritis (self-reported)	0.4	0.5	1.9	0.6	1.4	0.2	-0.5	0.1
Medication: Aspirin	0.7	0.9	1.4	1.0	0.4	-1.2	1.0	1.1
Medication: Gliclazide	0.6	0.7	1.4	0.8	0.5	-1.2	1.1	-0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.4	-0.4	0.2	0.4	-0.8
Smoking status: Current	0.5	0.7	2.2	-1.1	1.5	0.3	0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	5.8	-2.4	0.8	0.6	-0.6	-0.9
Whole body water mass	0.0	0.2	0.4	0.0	-0.1	0.6	-0.4	-0.6
Leg predicted mass (right)	0.1	0.7	1.5	-0.9	0.3	0.9	-1.2	-0.4
Arm fat mass (left)	0.3	1.2	4.0	-0.6	1.3	0.1	-2.0	0.2
Number of self-reported non-cancer illnesses	0.6	1.0	2.8	0.7	-0.1	-0.0	1.7	-1.3
Average weekly champagne plus white wine intake	0.5	0.8	1.2	-0.5	1.1	1.0	-0.8	0.8
Miserableness	0.5	0.9	2.4	-0.6	1.1	1.6	0.6	0.5
Guilty feelings	0.7	1.1	3.8	0.3	1.2	1.9	-0.3	-0.1
Wears glasses or contact lenses	0.4	0.5	1.2	0.1	0.9	-1.1	0.4	-0.4
Ever taken oral contraceptive pill	0.8	0.9	2.5	0.1	-0.2	-1.0	0.8	-1.6
Hearing aid user	0.6	0.7	1.5	-1.1	0.7	0.3	-1.2	0.5
Mother’s age at death	0.8	0.9	2.1	0.7	-1.2	-1.4	0.8	0.3
Financial situation satisfaction	0.7	0.8	2.3	-0.4	-0.4	-0.3	1.2	-1.5
Tinnitus: Yes, now most or all of the time	1.7	1.9	3.5	1.9	-0.3	0.4	1.7	1.7
Commuting to job workplace: Public transport	1.8	2.1	3.8	-1.9	0.3	0.9	-1.9	1.6
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	-0.1	0.8	0.6	0.4	-1.3
Medication: Blood pressure	0.4	0.9	2.0	1.4	-1.0	-0.9	0.6	0.1
Pain type(s) experienced in last month: Hip pain	1.2	1.5	5.6	2.4	1.3	-0.5	-0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.3	-0.5	-0.1	0.2	-0.4
High cholesterol (Self-reported)	0.8	1.3	3.9	-0.6	-2.0	-1.5	0.3	-0.4
Medication: Bendroflumethiazide	0.4	0.7	1.4	-1.1	-0.5	0.7	-1.2	-0.1
Medication: Paracetamol	0.4	0.6	1.7	-0.9	0.1	-1.3	0.7	-0.1
Medication: Lisinopril	0.5	0.7	1.5	-1.2	0.6	1.0	-0.8	-0.2
Medication: Atorvastatin	3.1	3.8	7.3	1.7	-2.1	-2.0	2.7	-0.5
Illnesses of father: High blood pressure	0.4	0.5	1.1	-0.8	1.0	0.4	-0.8	-0.2
Alcohol drinker status: Never	0.6	0.7	2.0	0.1	0.3	-1.4	-0.9	-0.7
Ever smoked	0.9	1.6	4.7	0.3	-2.2	-0.5	1.1	1.3
Basal metabolic rate	0.1	0.3	0.5	-0.4	0.1	0.6	-0.7	-0.7
Leg fat percentage (left)	0.3	1.0	1.8	-1.0	1.3	-0.7	-1.4	0.2
Arm fat-free mass (left)	0.0	0.2	0.5	-0.3	0.1	0.4	-0.7	-0.4
Number of operations (self-reported)	0.3	0.5	1.5	-0.8	0.0	-0.5	-0.2	1.2
Average weekly beer plus cider intake	0.9	1.3	2.2	1.3	1.2	0.6	0.9	-1.5
Irritability	1.1	1.9	6.9	-0.2	2.6	0.9	-1.1	0.9
Risk taking	0.9	1.4	5.8	-0.2	-0.5	0.3	2.4	-0.8
Ever had prostate specific antigen (PSA) test	1.5	1.8	4.8	1.1	0.7	2.2	0.3	1.5
Fractured/broken bones in last 5 years	0.3	0.4	1.7	-0.3	-0.5	-0.4	-0.2	1.3
Age started oral contraceptive pill	1.3	1.6	5.6	0.4	-1.5	-2.4	0.1	-0.4
Diastolic blood pressure, automated reading	0.4	1.2	4.5	2.1	0.1	-0.1	1.2	0.4
Ever depressed for a whole week	0.8	1.0	2.3	-1.5	1.2	0.5	0.5	0.8
Unable to work because of sickness or disability	0.1	0.1	0.5	-0.1	-0.1	-0.1	-0.0	-0.7
Commuting to job workplace: Cycle	1.1	1.3	6.1	0.2	0.4	2.5	0.5	0.2
Myopia	0.2	0.3	0.5	0.7	-0.0	0.6	0.3	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.8	-1.2	1.1	0.4	-0.3	-1.7
Cholesterol lowering medication	2.0	2.9	8.0	0.5	-2.3	-2.8	1.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.8	-2.0	-1.4	-1.2	0.1	-1.0
Pain experienced in last month	0.8	1.3	4.5	0.9	-2.1	-0.5	0.5	0.7
Supplements: Calcium	0.5	0.5	2.0	0.5	1.4	-0.6	0.0	0.0
Basal cell carcinoma (self-reported)	0.9	1.1	2.8	-0.2	-1.7	0.8	1.0	-0.9
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.2	0.9	-0.6	-1.8	0.9	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.2	0.4	1.8	0.7	-0.5	-0.0
Heart disease (siblings)	0.2	0.3	0.6	0.6	-0.2	-0.5	0.8	-0.3
Alcohol drinker status: Previous	3.5	4.0	6.2	0.2	-2.2	-2.0	2.2	-2.5
Pack years of smoking	0.4	0.6	1.5	0.7	-0.2	-1.2	-1.0	0.3
Impedance of whole body	0.1	0.4	0.8	-0.9	0.6	0.3	0.7	-0.2
Leg fat mass (left)	0.4	1.4	3.3	-1.2	1.5	-0.0	-1.8	-0.2
Arm predicted mass (left)	0.0	0.1	0.3	-0.1	0.1	0.5	-0.5	-0.3