Best TWAS P=8.07e-23 · Best GWAS P=9.61e-57 conditioned to 3.87e-22
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PDE4B | 0.15 | 0.10 | lasso | 10 | 0.11 | 3.7e-13 | 10.2 | -9.8 | 8.1e-23 | -0.56 | 1.00 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | TCTEX1D1 | 0.06 | 0.00 | bslmm | 574 | 0.03 | 5.1e-05 | -2.9 | 6.5 | 9.1e-11 | 0.52 | 0.47 | 0.13 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | SGIP1 | 0.19 | 0.01 | enet | 22 | 0.10 | 3.8e-08 | 2.3 | 6.9 | 6.9e-12 | 0.29 | 0.51 | 0.29 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | LEPR | 0.09 | 0.07 | blup | 505 | 0.06 | 4.6e-08 | -4.0 | 5.7 | 1.1e-08 | 0.14 | 1.00 | 0.00 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PDE4B | 0.03 | 0.00 | blup | 320 | 0.01 | 3.5e-02 | -5.2 | -9.3 | 2.0e-20 | -0.40 | 0.06 | 0.68 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGIP1 | 0.06 | 0.02 | blup | 240 | 0.04 | 5.4e-05 | -2.3 | 5.2 | 2.1e-07 | 0.21 | 0.55 | 0.02 | TRUE |