Hub : Genes

PDE4B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1530 0.0330 6.9e-09 0.103 0.076 0.095 0.105 0.109 1.8e-12 1.4e-09 1.3e-11 8.8e-13 3.7e-13
2 YFS Blood 0.0294 0.0112 1.3e-03 0.003 0.008 0.005 0.008 0.002 2.0e-02 9.4e-04 8.6e-03 9.1e-04 8.9e-02
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0346 0.0177 8.0e-03 0.003 0.008 0.006 NA 0.006 1.3e-01 3.5e-02 5.8e-02 NA 6.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 1.0 2.0 1.4 -0.4 -0.8
Bipolar Disorder or Schizophrenia 1.2 2.8 5.8 1.5 0.8 -2.4
Depressed Affect (Nagel 2018) 0.8 1.7 3.7 1.1 0.4 -1.9
Depression (Nagel 2018) 1.2 1.8 2.9 0.7 1.7 -1.5
Intelligence (Savage-Jansen 2018) 0.6 2.0 3.4 1.8 1.6 0.4
Neuroticism (Nagel 2018) 1.0 2.3 4.0 2.0 0.4 -1.6
Schizophrenia (2018) 1.3 2.8 5.9 0.7 1.4 -2.4
Schizophrenia vs Biploar Disorder 1.4 1.8 2.2 1.5 1.1 -1.4
Worry (Nagel 2018) 0.6 1.3 3.3 1.8 -0.5 0.7
Alzheimer’s Disease (in mother) 0.8 0.9 1.6 -0.8 -0.7 -1.2
Alzheimer’s Disease (in father) 0.4 0.5 1.3 1.1 -0.1 -0.3
Alzheimer’s Disease (including proxy) 1.0 1.5 4.1 0.5 -0.3 -2.0
Crohns Disease (2017) 1.5 3.4 6.9 2.6 0.8 1.6
Irritable Bowel Disease (IBD) 0.8 1.8 3.6 1.9 0.3 1.3
Ulcerative Colitis (UC) 0.2 0.4 0.6 0.8 -0.4 0.6
Major Depression (MDD) 2.3 2.8 5.4 -0.7 -2.3 -1.6
Reaction Time 1.9 3.6 9.1 -1.2 -0.5 -3.0
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.4 1.2 0.7 -0.1
Breast Cancer 1.5 3.6 8.1 -0.3 1.6 -2.8
Ovarian Cancer 0.8 1.1 1.9 1.4 1.2 -0.2
Prostate Cancer 0.3 0.4 0.6 0.7 0.8 -0.5
Age at First Birth 1.9 2.7 4.8 1.4 1.2 2.2
Bipolar Disorder (2011) 1.7 1.6 2.4 1.4 0.8 1.6
Body Mass Index (BMI) (2010) 0.6 0.9 1.9 -1.4 -0.5 -0.6
Coronary Artery Disease (CAD) 0.4 0.5 0.5 0.7 0.7 -0.6
Crohns Disease (2012) 0.8 1.2 3.5 1.9 0.4 0.0
Mean Putamen Volume 1.8 2.1 2.5 -1.3 -1.6 -1.5
Fasting Glucose 0.8 1.0 1.4 1.2 0.4 1.2
HbA1C 0.7 0.8 1.2 1.0 1.1 -0.0
HDL Cholesterol 0.8 1.3 3.3 -0.6 -1.8 -0.4
LDL Cholesterol 0.6 0.9 1.4 -1.2 1.0 -0.5
Lupus 0.3 0.4 0.9 -0.1 -0.9 0.6
Neuroticism (2016) 0.7 1.0 2.4 0.7 0.4 -1.6
Primary Biliary Cirrhosis 0.3 0.5 0.7 -0.8 -0.4 -0.8
Rheumatoid Arthritis 0.1 0.1 0.3 -0.1 0.6 0.3
Schizophrenia (2014) 1.0 2.1 4.8 1.1 0.7 -2.2
Triglycerides 0.8 1.3 3.3 -0.3 0.6 -1.8
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 -0.2 -0.5 0.3
Ulcerative Colitis 0.1 0.2 0.3 0.3 0.4 0.5
Blood Eosinophil Count 0.1 0.4 0.8 -0.6 -0.2 0.9
Blood Platelet Count 0.2 2.6 5.6 -0.4 -1.5 2.4
Blood Red Count 0.3 2.7 3.5 -1.5 -1.6 1.9
Blood White Count 1.4 10.4 30.2 0.9 0.2 5.5
Heel T-Score 0.5 3.7 7.6 -2.8 -1.0 -1.6
BMI 2.7 15.9 45.4 -1.4 0.6 -6.7
Height 0.2 4.2 8.2 -2.9 -1.0 -1.8
Waist Hip Ratio (WHR) 0.3 1.5 2.4 -1.1 -1.6 -0.8
Systolic Blood Pressure 0.6 3.2 4.9 1.8 -2.2 1.2
Smoking Status 8.0 19.0 42.8 -2.7 -2.6 -6.5
Allergy or Eczema 0.4 1.0 2.2 -0.7 0.5 1.5
Cardiovascular Disease 0.8 2.8 5.6 0.6 -2.4 -1.6
Hypothyroidism (self reported) 0.4 1.0 2.4 -0.2 0.8 -1.6
Respiratory disease 0.5 1.1 3.3 -0.2 -0.2 -1.8
Type 2 Diabetes (T2D) (2018) 1.4 2.7 4.7 1.5 2.2 -1.0
Lung FEV1/FVC ratio 0.7 3.3 8.1 -0.3 -1.4 -2.8
Lung FVC 0.3 1.3 3.1 0.2 -0.9 1.8
Neuroticism 0.7 1.7 4.0 1.0 -0.4 -2.0
Chronotype (morning person) 4.6 10.5 17.4 -4.2 -3.3 -1.7
Hair Pigment 0.1 3.4 5.4 -2.3 -0.4 -2.2
Tanning 5.6 68.9 96.6 -9.8 -4.9 -9.3
Hand grip strength (left) 1.4 3.7 6.0 -2.4 -2.0 -1.1
Number of treatments/medications taken 0.2 0.4 1.0 0.4 0.4 -1.0
Average weekly spirits intake 0.0 0.0 0.0 0.1 0.1 -0.2
Sensitivity / hurt feelings 0.9 1.6 3.2 0.6 1.8 -1.1
Frequency of depressed mood in last 2 weeks 1.2 1.7 4.8 -0.2 0.6 -2.2
Hearing difficulty/problems: Yes 1.8 2.8 4.3 0.5 -2.0 -2.1
Relative age of first facial hair 0.7 1.5 2.8 0.0 1.3 1.7
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 5.8 2.4 0.6 1.7
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.8 1.4 0.4 0.7
Ever had hysterectomy (womb removed) 2.3 2.6 6.1 1.0 2.5 0.8
Systolic blood pressure, automated reading 0.4 1.1 2.0 1.4 -1.0 0.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 0.8 -0.7 -0.9 -0.8
Angina 0.5 0.7 1.8 0.4 -0.0 -1.4
Medication for hormone replacement therapy 2.2 2.4 4.4 1.4 1.0 2.1
Vitamin and mineral supplements 0.1 0.2 0.5 -0.4 -0.0 -0.7
Supplements: Zinc 0.5 0.6 0.8 0.4 -0.8 -0.9
Medication: Co-codamol 0.6 0.7 1.6 -1.3 -0.4 -0.5
Medication: Metformin 0.4 0.5 0.7 0.5 0.8 -0.8
Diabetes (father) 1.0 1.3 2.9 -1.7 0.5 0.9
Diabetes (mother) 0.2 0.2 0.6 0.2 0.7 0.0
Severe depression (siblings) 0.7 0.8 1.4 0.9 -1.2 -0.4
Pack years adult smoking proportion 2.2 3.4 5.4 -1.1 -1.8 -2.3
Impedance of leg (right) 0.6 2.9 5.2 -1.1 -2.3 1.5
Leg fat-free mass (left) 1.1 5.9 16.9 -0.6 0.6 -4.1
Trunk fat percentage 2.4 9.6 26.5 -1.5 -0.0 -5.1
Hand grip strength (right) 0.2 0.5 0.8 -0.9 -0.8 -0.3
Townsend deprivation index at recruitment 1.2 1.7 2.8 1.7 -1.3 -0.8
Current tobacco smoking 5.8 9.4 13.8 -3.0 -2.4 -3.7
Average weekly fortified wine intake 0.3 0.3 0.5 0.7 0.6 -0.4
Maternal smoking around birth 2.2 3.2 5.0 -0.4 -2.1 -2.2
Fed-up feelings 0.3 0.6 1.0 1.0 0.5 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 3.0 -0.3 0.5 -1.7
Relative age voice broke 0.8 1.2 1.7 -0.8 1.3 1.1
Taking other prescription medications 2.1 3.2 6.1 2.5 1.8 0.3
Age when periods started (menarche) 2.6 6.2 7.6 2.8 2.3 2.4
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 2.8 -0.0 0.4 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.0 -0.5 1.0 1.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.6 0.2 -0.1 -0.8
Qualifications: CSEs or equivalent 1.7 2.2 3.8 -1.5 -2.0 -0.7
Serious illness, injury or assault to yourself 1.8 2.1 3.4 1.8 -1.0 1.4
High blood pressure 0.2 0.6 1.2 0.7 -1.1 0.0
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.3 0.2 0.2 0.5
Multivitamins +/- minerals 0.5 0.7 1.4 0.0 -0.8 1.2
Stomach or abdominal pain in last month 1.4 1.8 3.0 0.8 -1.3 -1.7
Supplements: Glucosamine 1.1 1.4 3.2 0.8 -1.8 0.7
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 4.8 -0.3 2.2 -1.2
Medication: Atenolol 0.5 0.6 1.9 1.4 -0.0 0.1
Medication: Levothyroxine sodium 0.1 0.1 0.3 0.3 0.5 -0.0
Sitting height 0.2 1.6 3.1 0.8 1.1 1.8
Chronic bronchitis/emphysema (father) 1.4 1.6 4.2 -0.2 -0.8 -2.0
High blood pressure (mother) 1.1 1.5 3.8 1.9 -0.1 0.8
Body mass index (BMI) 2.1 8.8 25.5 -0.2 0.9 -5.0
Impedance of leg (left) 0.5 2.6 3.0 -1.4 -1.7 1.6
Leg predicted mass (left) 1.0 5.5 15.8 -0.5 0.6 -4.0
Trunk fat mass 2.6 11.3 31.3 -1.6 -0.1 -5.6
Waist circumference 1.9 7.0 20.6 -0.5 0.3 -4.5
Number of incorrect matches in round 0.5 0.8 2.2 0.4 1.5 0.2
Past tobacco smoking 6.2 11.4 23.4 2.1 2.5 4.8
Alcohol usually taken with meals 0.4 0.6 0.9 -0.7 0.6 1.0
Nervous feelings 0.6 1.2 3.2 1.8 0.2 0.6
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.4 4.8 2.2 1.5 -0.4
Hearing difficulty/problems with background noise 1.0 1.6 3.6 0.6 -0.9 -1.9
Hair/balding pattern: Pattern 2 2.0 2.6 6.4 -0.2 -2.5 -1.1
Had menopause 1.8 2.3 3.2 1.6 1.0 1.8
Had other major operations 0.3 0.3 0.6 0.8 0.6 -0.2
Forced vital capacity (FVC) 0.2 0.8 1.6 -0.7 -1.3 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.8 -0.1 1.4 1.1
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 2.4 -0.7 -1.5 -1.2
Qualifications: None of the above 0.6 1.3 3.6 -0.1 -1.9 -0.6
Financial difficulties in last 2 years 1.0 1.4 4.1 -0.0 -0.3 -2.0
Mouth/teeth dental problems 2.5 3.8 5.3 1.4 2.0 2.3
Heart attack 1.2 1.6 3.5 0.8 1.9 0.8
Allergy 0.0 0.1 0.1 -0.2 -0.1 0.3
Pain all over the body in last month 1.1 1.1 1.8 1.3 1.2 0.2
Diabetes (self-reported) 2.3 3.5 5.5 1.7 2.3 -1.5
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.6 -0.0 1.9 -0.5
Medication: Ramipril 0.6 0.8 2.1 -0.4 0.4 -1.4
Medication: Simvastatin 0.2 0.2 0.5 0.7 -0.3 0.3
Fluid intelligence score 0.5 1.1 2.0 1.4 1.0 -0.3
Illnesses of siblings 1.9 2.6 4.8 -2.2 1.7 -0.5
Neuroticism score 0.6 1.2 2.2 1.5 0.6 -1.1
Weight 2.0 9.8 28.2 -1.1 0.4 -5.3
Impedance of arm (right) 0.3 1.3 1.7 -0.9 -1.3 1.2
Arm fat percentage (right) 2.0 8.0 23.4 -0.8 0.0 -4.8
Trunk fat-free mass 0.5 3.1 8.8 -0.7 0.3 -3.0
Hip circumference 1.8 7.9 22.3 -0.1 1.1 -4.7
Time employed in main current job 0.4 0.4 0.7 -0.7 0.2 0.8
Alcohol intake versus 10 years previously 0.5 0.7 2.0 1.4 -0.3 0.0
Father’s age at death 0.3 0.4 0.8 -0.9 0.7 -0.1
Worrier / anxious feelings 0.2 0.3 0.8 0.5 0.2 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 3.0 1.7 0.6 -0.0
Falls in the last year 2.1 2.9 7.8 -0.6 -0.6 -2.8
Hair/balding pattern: Pattern 3 0.3 0.5 0.9 -0.7 -0.9 -0.4
Number of live births 0.4 0.5 1.6 0.0 -1.2 -0.1
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.7 -1.0 -1.6 -0.5
Pulse rate 0.3 0.4 0.9 -0.9 -0.4 0.5
Happiness 1.6 1.9 5.1 0.2 2.3 0.8
Noisy workplace 2.0 2.4 4.8 -1.3 -2.2 -0.8
Qualifications: A levels/AS levels or equivalent 3.6 8.0 11.0 2.7 2.4 3.3
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.1 0.1 0.2 0.2 0.3
Mouth/teeth dental problems: Dentures 2.3 3.9 8.1 -1.7 -2.9 -0.8
Asthma 0.1 0.2 0.7 0.8 0.1 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.2 -0.3 -0.5
Medication: Cholesterol lowering 0.3 0.4 1.0 1.0 0.4 -0.1
Depression (self-reported) 0.6 0.7 0.9 0.9 0.9 -0.8
Medication: Lansoprazole 1.4 1.6 4.0 -0.8 0.2 -2.0
Prospective memory result 0.3 0.4 0.7 -0.8 0.7 -0.2
Lung cancer (father) 0.3 0.3 0.8 0.1 -0.9 -0.4
Illnesses of mother 0.1 0.1 0.4 -0.0 0.0 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.1 -0.8 -1.5 -0.2
Pulse wave Arterial Stiffness index 1.8 2.1 5.3 -0.3 -2.3 1.0
Impedance of arm (left) 0.2 1.1 1.8 -1.0 -0.8 1.4
Arm fat mass (right) 2.3 9.5 27.5 -0.8 0.6 -5.2
Trunk predicted mass 0.5 3.0 8.6 -0.6 0.4 -2.9
Standing height 0.3 2.8 5.1 -2.2 -1.2 -1.4
Length of working week for main job 0.5 0.6 1.3 0.3 1.1 -0.6
Exposure to tobacco smoke at home 0.3 0.3 0.8 -0.9 -0.2 0.2
Breastfed as a baby 0.7 0.9 1.5 0.4 0.9 1.2
Tense / ‘highly strung’ 1.0 1.7 3.4 1.9 -0.6 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 4.6 2.1 -1.0 -0.9
Hair/balding pattern: Pattern 4 0.1 0.3 0.7 0.0 0.5 0.8
Birth weight of first child 0.8 1.4 3.1 -0.1 1.0 -1.8
Peak expiratory flow (PEF) 0.2 0.4 0.6 -0.4 -0.7 -0.8
Pulse wave reflection index 0.4 0.5 0.8 0.9 -0.7 -0.3
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.7 0.6 -0.8 0.1
Loud music exposure frequency 1.1 1.2 2.3 1.5 1.2 0.0
Qualifications: O levels/GCSEs or equivalent 0.7 1.0 2.4 0.8 0.3 1.5
Mouth/teeth dental problems: Bleeding gums 1.4 1.9 3.9 0.5 -1.2 -2.0
Blood clot in the leg (DVT) 0.2 0.3 0.5 0.7 -0.4 -0.4
Medication: Paracetamol 0.1 0.2 0.5 -0.0 -0.3 -0.7
Headache pain in last month 0.3 0.5 1.6 0.0 0.1 -1.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.6 -0.8 -0.7 -0.3
Glaucoma (self-reported) 1.6 1.9 3.0 1.1 1.7 1.2
Gout (self-reported) 0.3 0.4 0.6 -0.8 -0.8 -0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.6 0.4 0.8 -0.6
Medication: Amlodipine 0.1 0.2 0.3 0.3 -0.5 -0.5
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.1 0.5 0.4
Birth weight 0.9 1.9 3.9 -0.6 -1.1 -2.0
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.3 0.5 -0.5 -0.5
High blood pressure (siblings) 2.9 4.1 9.5 3.1 -0.4 1.6
Forced vital capacity (FVC), Best measure 0.3 1.1 2.0 -1.0 -1.4 0.7
Body fat percentage 2.4 9.5 26.8 -1.3 -0.2 -5.2
Leg fat percentage (right) 2.4 8.7 24.5 -0.9 -0.9 -5.0
Arm fat-free mass (right) 0.9 4.4 12.1 -0.8 0.7 -3.5
Exposure to tobacco smoke outside home 0.5 0.7 1.3 -0.2 -0.9 -1.2
Comparative body size at age 10 1.9 5.2 15.1 0.1 0.7 -3.9
Number of full brothers 0.5 0.6 1.3 0.3 -1.1 -0.6
Worry too long after embarrassment 1.2 2.0 4.0 1.4 2.0 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.3 6.9 2.6 0.4 -0.2
Wheeze or whistling in the chest in last year 0.6 1.1 2.9 0.0 -0.7 -1.7
Number of children fathered 1.0 1.2 1.7 1.3 1.0 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.6 -0.2 0.5 -0.8
Age at first live birth 3.4 6.0 11.1 0.3 2.6 3.3
Pulse wave peak to peak time 1.5 1.8 4.3 0.2 2.1 -1.0
Health satisfaction 0.6 0.7 2.1 -0.0 -0.2 -1.5
Shortness of breath walking on level ground 0.0 0.0 0.1 -0.2 -0.2 0.2
Qualifications: College or University degree 1.4 4.5 6.4 2.0 2.5 1.7
Eye problems/disorders: None of the above 1.6 1.8 4.7 -0.8 -2.2 0.4
Mouth/teeth dental problems: Loose teeth 3.7 4.4 6.8 -0.4 -2.5 -2.6
Emphysema/chronic bronchitis 2.6 3.0 6.0 -0.8 -2.4 -1.5
Medication for pain relief, constipation, heartburn 0.5 0.9 1.3 -1.1 -0.6 1.0
Neck or shoulder pain in last month 0.7 1.0 1.6 0.0 -1.3 1.2
Medication: Blood pressure 0.7 1.3 1.6 1.0 1.3 1.1
Angina (self-reported) 0.6 0.8 2.2 0.3 0.1 -1.5
Migraine (self-reported) 2.5 3.0 4.2 -2.0 -1.5 -1.6
Medication: Ibuprofen 0.1 0.1 0.2 -0.2 -0.3 -0.4
Medication: Allopurinol 0.3 0.4 0.8 -0.9 0.1 -0.6
Medication: Omeprazole 1.1 1.3 2.6 1.1 0.1 -1.6
Medication: Seretide 50 evohaler 2.0 2.3 5.2 1.2 2.3 0.5
Mean time to correctly identify matches 0.7 1.2 3.6 -0.4 -0.1 -1.9
Heart disease (mother) 0.7 0.8 1.7 0.5 0.6 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.8 0.4 0.2 0.9
Whole body fat mass 2.6 10.8 30.7 -1.3 0.0 -5.5
Leg fat mass (right) 2.6 10.0 29.3 -0.8 -0.3 -5.4
Arm predicted mass (right) 1.0 5.3 14.4 -0.7 1.1 -3.8
Pulse rate, automated reading 0.3 0.9 1.3 -1.1 -0.9 -0.6
Alcohol intake frequency. 0.8 1.8 3.8 1.2 -0.5 2.0
Comparative height size at age 10 3.1 17.3 22.2 -4.1 -3.6 -4.7
Number of full sisters 0.6 0.7 2.0 0.2 0.0 -1.4
Suffer from ‘nerves’ 1.0 1.5 2.0 1.4 1.1 1.2
Overall health rating 1.0 2.2 5.5 1.0 -0.2 -2.3
Chest pain or discomfort 0.7 1.1 3.0 0.1 -0.4 -1.7
Had major operations 0.6 0.7 2.1 1.4 0.2 -0.3
Age at last live birth 0.6 0.9 1.8 0.1 1.0 1.4
Family relationship satisfaction 0.5 0.6 1.1 -0.8 1.0 -0.1
Leg pain on walking 0.6 0.8 1.2 -1.1 -1.0 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.4 -0.3 -0.6 0.1
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.8 -0.9 -0.0 0.1
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.8 -0.9 0.8 0.1
Medication: Aspirin 2.5 3.3 4.3 2.1 1.9 1.4
Supplements: Vitamin C 0.6 0.7 1.6 0.1 1.3 0.6
Knee pain experienced in last month 0.9 1.4 3.2 -0.7 -1.8 -0.7
Hypertension (Self-reported) 0.2 0.7 1.2 0.9 -1.1 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.8 1.3 0.3 -0.0
Illnesses of father: Heart disease 0.3 0.5 0.5 0.6 -0.7 -0.7
Illnesses of siblings: Diabetes 0.1 0.1 0.3 0.5 -0.1 0.2
Smoking status: Previous 2.4 3.7 8.1 -0.7 -1.6 -2.9
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.3 -0.5 -0.5 -0.1
Whole body fat-free mass 0.7 4.3 12.1 -0.7 0.5 -3.5
Leg fat-free mass (right) 0.9 4.8 13.4 -0.7 0.8 -3.7
Arm fat percentage (left) 2.1 8.2 23.5 -1.0 0.4 -4.8
Average weekly red wine intake 0.2 0.3 0.5 0.3 0.6 0.7
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.6 -1.3 0.4 -0.6
Mood swings 0.6 1.1 1.6 1.3 0.1 -1.3
Loneliness, isolation 0.4 0.6 1.3 1.1 0.7 0.3
Long-standing illness, disability or infirmity 0.9 1.4 3.2 1.0 -0.4 -1.8
Ever had bowel cancer screening 1.9 2.2 3.5 1.9 -0.5 1.7
Diabetes diagnosed by doctor 1.4 2.3 3.6 1.8 1.9 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.4 0.5 -0.4 -1.2
Friendships satisfaction 0.1 0.1 0.2 0.2 0.3 0.5
Qualifications: nursing, teaching 0.6 1.0 1.6 1.0 0.6 1.3
Commuting to job workplace: Walk 0.7 0.8 1.6 1.3 0.6 0.6
Eye problems/disorders: Cataract 2.6 3.0 5.0 2.2 2.0 0.2
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 -0.2 0.3 -0.0
Medication for cholesterol 0.8 1.2 3.0 -1.7 -0.8 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 0.4 -0.5 -0.2
Back pain experienced in last month 1.0 1.4 3.3 0.2 -1.0 -1.8
Mineral and other dietary supplements 1.4 1.8 3.4 -0.6 1.3 -1.9
Breast cancer (self-reported) 1.1 1.4 3.4 -0.7 0.5 -1.9
Asthma (self-reported) 0.1 0.2 0.3 0.6 -0.4 -0.3
Osteoporosis (self-reported) 0.8 1.0 1.7 1.3 0.2 1.1
Osteoarthritis (self-reported) 1.8 2.4 6.6 -0.4 -0.5 -2.6
Medication: Aspirin 1.6 2.1 3.0 1.7 1.5 1.0
Medication: Gliclazide 1.7 1.9 2.7 1.6 -0.9 1.5
Illnesses of father: None of the above (group 1) 0.6 0.7 1.6 0.0 0.7 1.3
Smoking status: Current 5.8 9.1 13.2 -2.9 -2.4 -3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.6 0.1 -0.8 -0.5
Whole body water mass 0.8 4.3 12.2 -0.7 0.5 -3.5
Leg predicted mass (right) 0.9 4.9 13.5 -0.6 0.8 -3.7
Arm fat mass (left) 2.5 10.2 29.3 -1.0 0.6 -5.4
Number of self-reported non-cancer illnesses 0.6 1.1 1.8 1.4 1.0 -0.7
Average weekly champagne plus white wine intake 0.7 1.0 2.8 0.5 1.7 -0.2
Miserableness 0.8 1.3 2.4 1.5 0.8 -1.0
Guilty feelings 0.9 1.4 4.0 0.2 0.1 -2.0
Wears glasses or contact lenses 0.4 0.5 1.0 0.6 -1.0 0.3
Ever taken oral contraceptive pill 1.1 1.2 1.4 -1.2 -1.1 1.0
Hearing aid user 2.1 2.3 3.4 -1.4 -1.8 -1.3
Mother’s age at death 2.2 2.8 5.1 1.2 1.3 2.3
Financial situation satisfaction 0.0 0.0 0.1 -0.1 0.0 -0.4
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 -0.2 -0.7 0.4
Commuting to job workplace: Public transport 0.4 0.5 0.8 0.6 -0.9 -0.3
Eye problems/disorders: Glaucoma 3.4 4.0 6.4 1.7 2.5 1.7
Medication: Blood pressure 0.5 0.9 1.6 1.0 -0.4 -1.3
Pain type(s) experienced in last month: Hip pain 1.5 1.9 4.2 -0.1 -1.2 -2.1
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.6 0.0 -0.8 0.5
High cholesterol (Self-reported) 0.2 0.3 0.8 0.9 -0.2 -0.3
Medication: Bendroflumethiazide 0.6 0.9 1.8 0.9 -1.4 -0.4
Medication: Paracetamol 0.1 0.2 0.4 -0.1 -0.3 -0.6
Medication: Lisinopril 2.4 3.1 3.6 1.4 1.9 1.9
Medication: Atorvastatin 1.9 2.3 5.7 2.4 0.6 -1.0
Illnesses of father: High blood pressure 0.4 0.5 1.3 -0.3 -0.5 -1.1
Alcohol drinker status: Never 0.0 0.0 0.1 0.3 0.0 0.2
Ever smoked 8.1 14.3 27.5 -2.9 -2.6 -5.2
Basal metabolic rate 1.1 6.0 17.1 -0.8 0.5 -4.1
Leg fat percentage (left) 2.2 8.0 22.9 -1.0 -0.4 -4.8
Arm fat-free mass (left) 0.9 4.4 12.5 -0.5 0.7 -3.5
Number of operations (self-reported) 1.1 1.7 2.1 1.1 1.3 -1.5
Average weekly beer plus cider intake 1.0 1.5 2.8 1.7 0.5 -1.2
Irritability 1.5 2.6 5.1 2.3 0.4 -1.6
Risk taking 1.1 1.6 4.3 -0.0 0.6 -2.1
Ever had prostate specific antigen (PSA) test 1.2 1.4 2.8 0.3 1.2 1.7
Fractured/broken bones in last 5 years 0.7 0.9 2.4 1.6 0.4 -0.5
Age started oral contraceptive pill 0.4 0.5 0.7 -0.9 -0.4 0.7
Diastolic blood pressure, automated reading 0.6 2.0 4.6 -0.4 -1.1 -2.1
Ever depressed for a whole week 1.2 1.4 3.5 0.2 -1.9 -0.9
Unable to work because of sickness or disability 0.7 0.9 1.1 1.0 -0.7 -1.1
Commuting to job workplace: Cycle 1.1 1.3 2.4 1.6 1.2 -0.1
Myopia 0.6 0.8 1.3 1.1 -1.1 0.2
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.8 -0.2 0.9 0.2
Cholesterol lowering medication 1.2 1.8 5.4 2.3 0.3 0.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.2 0.9 -0.3 -1.1
Pain experienced in last month 2.0 3.3 6.5 1.5 1.1 2.5
Supplements: Calcium 2.2 2.4 3.7 1.9 1.1 1.6
Basal cell carcinoma (self-reported) 0.6 0.7 1.3 0.8 0.2 1.1
Heart attack/myocardial infarction (self-reported) 0.8 1.1 2.8 0.5 1.7 0.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.0 1.0 -0.3 -0.2
Heart disease (siblings) 2.5 3.1 4.7 -0.8 -2.0 -2.2
Alcohol drinker status: Previous 1.2 1.4 2.0 -0.7 -1.4 -1.3
Pack years of smoking 1.6 2.4 3.4 -0.9 -1.7 -1.8
Impedance of whole body 0.4 1.9 2.9 -1.1 -1.3 1.7
Leg fat mass (left) 2.5 9.6 28.2 -0.8 -0.2 -5.3
Arm predicted mass (left) 0.9 4.8 13.8 -0.6 0.6 -3.7