Best TWAS P=1.2e-13 · Best GWAS P=1.68e-13 conditioned to 0.0213
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | ADO | 0.15 | 0.16 | lasso | 8 | 0.16 | 1.1e-15 | -4.9 | -5.1 | 2.8e-07 | -0.63 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Muscle Skeletal | RP11-436D10.3 | 0.08 | 0.04 | enet | 13 | 0.06 | 3.2e-06 | 5.8 | -5.7 | 1.4e-08 | -0.73 | 0.19 | 0.80 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | NRBF2 | 0.06 | 0.01 | lasso | 3 | 0.00 | 4.0e-01 | 7.4 | -7.4 | 1.2e-13 | -0.81 | 0.02 | 0.74 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | ADO | 0.06 | 0.04 | lasso | 2 | 0.06 | 3.1e-08 | 5.8 | -6.4 | 1.3e-10 | -0.83 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADO | 0.03 | 0.02 | blup | 53 | 0.03 | 1.8e-06 | -5.1 | -6.3 | 3.8e-10 | -0.77 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADO | 0.10 | 0.03 | enet | 6 | 0.06 | 4.6e-07 | -5.3 | -6.4 | 1.2e-10 | -0.81 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADO | 0.06 | 0.04 | blup | 55 | 0.01 | 1.4e-01 | 5.8 | -6.2 | 7.1e-10 | -0.83 | 0.01 | 0.76 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | ADO | 0.12 | 0.10 | lasso | 5 | 0.09 | 5.2e-09 | 5.8 | -6.2 | 5.2e-10 | -0.86 | 0.03 | 0.97 | FALSE |