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chr11:67,976,812-69,623,641

Best TWAS P=5.6e-55 · Best GWAS P=4.03e-49 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RP11-554A11.9	0.34	0.13	enet	43	0.26	4.1e-21	-13.09	-7.7	1.9e-14	0.39	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	RP11-554A11.9	0.28	0.01	enet	27	0.13	4.3e-07	-13.09	-6.6	4.2e-11	0.41	0.31	0.15	FALSE
3	GTEx	Adrenal Gland	IGHMBP2	0.25	0.10	enet	25	0.18	5.1e-07	-3.56	-5.1	2.7e-07	0.20	0.78	0.01	FALSE
4	GTEx	Artery Aorta	TPCN2	0.21	0.17	lasso	2	0.16	5.5e-09	-8.15	-5.8	8.3e-09	0.08	0.99	0.00	FALSE
5	GTEx	Artery Aorta	RP11-554A11.9	0.37	0.18	enet	23	0.27	3.3e-15	-13.09	-9.8	6.6e-23	0.38	0.98	0.01	FALSE
6	GTEx	Artery Tibial	RP11-554A11.9	0.34	0.06	enet	35	0.22	4.0e-17	0.99	-8.8	1.1e-18	0.45	0.99	0.00	FALSE
7	GTEx	Brain Cerebellar Hemisphere	RP11-554A11.9	0.49	0.17	lasso	9	0.20	8.5e-06	-14.15	-9.8	1.4e-22	0.84	0.01	0.99	TRUE
8	GTEx	Brain Cerebellum	RP11-554A11.9	0.59	0.16	enet	29	0.33	1.4e-10	-11.07	-9.9	3.5e-23	0.66	0.01	0.98	FALSE
9	GTEx	Brain Cortex	RP11-554A11.9	0.47	0.18	enet	31	0.22	7.0e-07	-11.07	-10.8	2.7e-27	0.66	0.01	0.97	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	IGHMBP2	0.37	0.08	enet	46	0.12	5.6e-04	-3.44	-7.4	1.3e-13	0.27	0.25	0.09	TRUE
11	GTEx	Breast Mammary Tissue	TPCN2	0.21	0.01	enet	44	0.12	1.7e-06	-5.61	-8.0	1.9e-15	0.10	0.09	0.04	FALSE
12	GTEx	Breast Mammary Tissue	RP11-554A11.9	0.32	0.11	lasso	7	0.26	9.4e-14	-13.09	-7.8	4.3e-15	0.56	0.41	0.49	FALSE
13	GTEx	Breast Mammary Tissue (Male)	RP11-554A11.9	0.23	0.08	lasso	4	0.08	6.7e-03	-10.48	-8.6	1.2e-17	0.71	0.05	0.35	TRUE
14	GTEx	Breast Mammary Tissue (Female)	TPCN2	0.11	-0.01	enet	7	0.03	5.2e-02	-4.32	-10.1	8.1e-24	0.26	0.05	0.07	FALSE
15	GTEx	Breast Mammary Tissue (Female)	RP11-554A11.9	0.40	0.25	enet	18	0.30	1.5e-09	-13.09	-8.0	1.1e-15	0.47	0.49	0.17	FALSE
16	GTEx	Colon Sigmoid	RP11-554A11.9	0.65	0.29	enet	36	0.41	8.3e-16	-13.09	-9.7	3.6e-22	0.59	0.97	0.02	FALSE
17	GTEx	Colon Transverse	RP11-554A11.9	0.26	0.11	lasso	9	0.10	2.5e-05	-11.07	-12.6	1.6e-36	0.81	0.02	0.95	FALSE
18	GTEx	Esophagus Mucosa	RP11-554A11.9	0.23	0.18	lasso	3	0.18	4.0e-12	-13.09	-12.6	2.8e-36	0.35	1.00	0.00	FALSE
19	GTEx	Esophagus Muscularis	TPCN2	0.23	0.01	lasso	5	0.01	6.0e-02	10.85	-10.3	4.5e-25	0.29	0.12	0.07	FALSE
20	GTEx	Esophagus Muscularis	RP11-554A11.9	0.31	0.18	lasso	9	0.22	1.4e-13	-13.09	-13.9	9.7e-44	0.57	0.96	0.03	TRUE
21	GTEx	Heart Atrial Appendage	IGHMBP2	0.26	0.27	lasso	4	0.26	3.9e-12	-5.57	-5.3	9.4e-08	0.10	1.00	0.00	FALSE
22	GTEx	Heart Atrial Appendage	RP11-554A11.9	0.24	0.05	lasso	8	0.09	9.5e-05	-3.89	-10.8	2.5e-27	0.61	0.04	0.76	FALSE
23	GTEx	Heart Left Ventricle	RP11-554A11.9	0.16	0.11	lasso	3	0.09	2.2e-05	-13.09	-13.5	1.7e-41	0.54	0.26	0.34	FALSE
24	GTEx	Lung	RP11-554A11.9	0.28	0.10	enet	34	0.20	1.6e-15	-13.09	-10.9	1.1e-27	0.60	0.24	0.76	FALSE
25	GTEx	Nerve Tibial	RP11-554A11.9	0.43	0.10	lasso	11	0.33	8.7e-24	-13.09	-9.5	2.0e-21	0.55	0.78	0.21	FALSE
26	GTEx	Prostate	RP11-554A11.9	0.44	0.11	enet	13	0.18	2.8e-05	-11.62	-15.6	5.6e-55	0.85	0.01	0.94	TRUE
27	GTEx	Skin Not Sun Exposed Suprapubic	TPCN2	0.19	0.10	lasso	4	0.10	3.0e-06	-8.15	-10.1	4.4e-24	0.19	0.90	0.01	TRUE
28	GTEx	Skin Not Sun Exposed Suprapubic	RP11-554A11.9	0.28	0.13	lasso	9	0.21	1.5e-11	3.18	-5.6	1.9e-08	0.54	0.27	0.68	FALSE
29	GTEx	Skin Sun Exposed Lower leg	TPCN2	0.09	0.00	lasso	5	0.03	8.0e-04	-8.15	-5.8	9.2e-09	0.08	0.14	0.04	FALSE
30	GTEx	Testis	TPCN2	0.26	0.05	lasso	3	0.07	5.9e-04	-8.21	-9.5	1.9e-21	0.14	0.14	0.04	FALSE
31	GTEx	Thyroid	RP11-554A11.9	0.40	0.14	lasso	7	0.25	8.1e-19	-13.09	-11.9	1.7e-32	0.59	0.83	0.16	FALSE
32	GTEx	Vagina	IGHMBP2	0.34	-0.01	enet	34	0.16	2.0e-04	-4.58	-6.7	2.9e-11	0.16	0.09	0.06	FALSE
33	GTEx	Vagina	RP11-554A11.9	0.49	0.11	lasso	6	0.12	9.5e-04	-14.15	-14.5	6.9e-48	0.81	0.01	0.87	FALSE
34	METSIM	Adipose	MRGPRF	0.18	0.14	enet	13	0.19	2.8e-27	-4.27	-5.8	6.0e-09	0.14	1.00	0.00	FALSE
35	METSIM	Adipose	TPCN2	0.42	0.29	enet	46	0.34	1.1e-51	-4.27	-10.5	5.6e-26	0.26	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	TPCN2	0.06	0.04	blup	98	0.04	8.4e-06	-13.09	-7.7	1.9e-14	0.29	0.51	0.02	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	TPCN2	0.11	0.05	lasso	5	0.05	1.5e-05	9.82	-11.1	9.7e-29	0.29	0.91	0.04	TRUE