Hub : Genes

MRGPRF

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.121	0.0380	1.5e-05	0.110	0.044	0.081	0.095	0.102	2.4e-13	4.5e-06	4.7e-10	1.3e-11	2.2e-12
2	GTEx	Adipose Subcutaneous	0.073	0.0320	3.4e-03	0.027	NA	0.006	NA	0.013	2.5e-03	NA	9.7e-02	NA	3.0e-02
3	GTEx	Brain Cerebellum	0.175	0.0740	6.3e-03	0.191	NA	0.106	NA	0.144	2.5e-06	NA	5.0e-04	NA	5.1e-05
4	GTEx	Esophagus Muscularis	0.093	0.0410	3.9e-03	0.014	NA	-0.004	NA	0.006	4.5e-02	NA	7.4e-01	NA	1.3e-01
5	GTEx	Liver	0.275	0.1020	6.0e-03	0.026	NA	0.014	NA	0.021	6.3e-02	NA	1.3e-01	NA	8.6e-02
6	METSIM	Adipose	0.183	0.0421	1.3e-14	0.135	0.126	0.187	0.170	0.070	1.3e-19	2.5e-18	2.8e-27	1.2e-24	1.2e-10
7	ROSMAP	Brain Pre-frontal Cortex	0.107	0.0279	1.1e-07	0.099	0.078	0.108	0.109	0.108	1.0e-12	2.8e-10	9.4e-14	6.9e-14	1.1e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.6	4.1	11.1	2.0	-1.3	3.3	-2.4	1.1	-1.5	1.7
Bipolar Disorder or Schizophrenia	1.1	2.6	10.7	0.4	-1.4	3.3	-1.0	-0.3	-2.0	0.3
Depressed Affect (Nagel 2018)	1.5	3.1	8.8	1.3	1.2	3.0	-2.5	0.3	0.8	1.7
Depression (Nagel 2018)	0.8	1.2	2.8	-0.6	1.7	1.6	-1.1	-0.8	0.7	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.5	-0.1	0.9	-0.2	1.2	-0.0	0.4	0.6
Neuroticism (Nagel 2018)	0.9	2.1	7.0	0.9	0.4	2.2	-2.6	-0.5	0.4	1.1
Schizophrenia (2018)	0.6	1.2	2.2	-1.1	-0.8	1.5	0.7	-1.1	-1.4	-0.9
Schizophrenia vs Biploar Disorder	3.7	4.9	9.4	-3.0	1.0	-1.3	1.9	-3.1	-0.4	-3.0
Worry (Nagel 2018)	0.4	0.8	4.6	-0.1	-0.2	0.7	-2.1	-0.3	0.0	-0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.1	-0.7	-0.7	0.1	0.2	-0.1	-0.4
Alzheimer’s Disease (in father)	0.4	0.4	1.4	0.7	-1.2	0.0	0.3	0.4	-0.5	0.5
Alzheimer’s Disease (including proxy)	1.1	1.7	4.7	1.7	-2.2	-0.6	0.5	1.1	-1.0	1.1
Crohns Disease (2017)	0.6	1.3	3.8	-0.9	0.6	-2.0	2.0	-0.4	0.3	-0.5
Irritable Bowel Disease (IBD)	0.6	1.3	2.5	-1.3	1.6	-1.5	0.6	-0.9	0.9	-1.0
Ulcerative Colitis (UC)	0.5	0.9	2.4	-1.1	1.5	-0.6	-0.2	-0.6	1.2	-0.9
Major Depression (MDD)	0.4	0.5	1.0	-0.4	-0.4	1.0	-1.0	0.9	0.4	-0.6
Reaction Time	0.6	1.1	3.9	1.0	-2.0	0.8	-0.4	1.2	-0.1	0.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.4	0.8	0.5	-0.3	1.8	0.5	-0.2	1.4
Breast Cancer	0.3	0.6	2.7	0.6	-0.7	0.5	0.4	1.6	-0.1	0.6
Ovarian Cancer	0.7	0.9	2.2	-0.7	1.5	1.0	-0.6	-1.4	0.5	-0.6
Prostate Cancer	0.4	0.5	1.2	-0.7	-1.1	-0.6	-0.1	-0.6	-0.6	-0.9
Age at First Birth	0.4	0.5	1.2	-0.6	0.0	-1.1	0.8	-1.0	-0.6	-0.3
Bipolar Disorder (2011)	2.4	2.3	6.1	1.9	-1.7	0.0	-2.5	0.0	0.6	1.8
Body Mass Index (BMI) (2010)	1.9	2.7	7.1	-1.0	2.6	-0.5	1.4	-2.7	0.4	-1.2
Coronary Artery Disease (CAD)	0.4	0.5	1.6	0.4	-1.3	0.9	-0.7	0.5	-0.0	0.5
Crohns Disease (2012)	0.6	0.9	4.2	-0.3	-0.6	-2.0	1.1	0.5	-0.7	-0.5
Mean Putamen Volume	0.2	0.3	1.3	-0.0	0.0	0.4	-0.5	-1.1	-0.3	0.1
Fasting Glucose	1.0	1.2	3.7	0.4	-1.0	-0.9	1.9	0.9	-1.4	0.5
HbA1C	0.3	0.3	1.2	-0.3	-0.2	-0.8	1.1	-0.2	0.1	-0.4
HDL Cholesterol	0.7	1.2	3.3	1.2	-1.8	-0.9	0.3	1.3	-0.8	0.6
LDL Cholesterol	0.7	1.1	3.7	-0.1	-1.9	-0.7	-0.7	-0.3	-1.5	-0.6
Lupus	0.1	0.2	0.8	0.0	0.9	-0.6	0.2	-0.1	0.5	0.2
Neuroticism (2016)	0.4	0.6	1.8	0.7	-1.3	0.5	-0.5	0.6	0.1	1.0
Primary Biliary Cirrhosis	0.5	0.7	2.6	-0.4	0.3	1.6	-1.5	0.0	-0.4	-0.1
Rheumatoid Arthritis	1.0	1.4	4.2	0.4	1.8	1.1	-0.1	0.6	2.1	0.9
Schizophrenia (2014)	0.7	1.5	5.1	-0.5	-1.2	1.5	0.3	-0.9	-2.3	-0.7
Triglycerides	0.7	1.2	2.9	-0.9	1.7	-0.1	-1.2	-1.6	-0.2	-0.8
Type 2 Diabetes (T2D) (2012)	1.4	1.7	5.2	1.1	-1.5	0.8	-0.9	0.8	-2.3	1.0
Ulcerative Colitis	0.4	0.5	1.2	-0.8	1.0	-0.2	-0.5	0.3	1.1	-0.7
Blood Eosinophil Count	0.9	6.6	19.4	-2.6	2.2	-3.0	4.4	-1.2	1.1	-1.7
Blood Platelet Count	0.1	0.7	2.3	-0.5	-0.1	-1.0	0.1	1.5	1.2	-0.2
Blood Red Count	0.4	4.0	12.1	-1.0	-2.4	-3.5	2.6	1.1	-0.1	-0.8
Blood White Count	0.0	0.3	0.8	-0.9	0.4	0.8	0.1	-0.1	0.5	-0.8
Heel T-Score	6.5	51.4	225.0	-4.0	2.9	-10.1	15.0	-2.0	-0.7	-2.1
BMI	1.2	7.1	15.6	-1.7	4.0	-1.2	3.9	0.7	3.7	0.1
Height	2.4	46.3	174.2	-2.5	5.5	-10.3	13.2	-1.3	2.3	-0.6
Waist Hip Ratio (WHR)	0.8	3.5	6.9	2.6	-0.7	2.1	-1.9	0.9	1.8	2.2
Systolic Blood Pressure	1.7	8.7	21.3	3.7	-4.6	1.3	-2.0	2.6	-2.2	2.9
Smoking Status	0.2	0.6	2.2	0.2	-0.6	1.5	0.3	-1.0	-0.5	-0.3
Allergy or Eczema	1.5	4.0	14.0	0.8	-1.9	-2.3	1.4	3.7	1.0	1.3
Cardiovascular Disease	0.1	0.5	1.8	0.8	-1.3	0.4	-0.4	0.1	-0.0	0.7
Hypothyroidism (self reported)	0.7	1.5	4.7	-0.2	-0.1	0.6	-2.2	-1.8	-1.4	-0.6
Respiratory disease	0.4	1.0	1.5	-1.2	0.9	-1.0	0.7	0.1	1.2	-1.2
Type 2 Diabetes (T2D) (2018)	2.1	3.9	8.5	2.9	-1.7	-0.2	-0.6	2.1	-1.7	2.8
Lung FEV1/FVC ratio	0.3	1.7	4.9	-1.3	1.2	-0.6	2.2	-0.6	1.4	-0.9
Lung FVC	0.9	4.7	13.1	-1.3	2.7	-2.4	3.6	-1.3	1.7	-0.6
Neuroticism	0.8	1.8	5.8	0.9	-0.2	2.4	-2.3	-0.3	0.1	0.9
Chronotype (morning person)	0.5	1.1	5.4	-0.8	2.3	0.2	-0.4	-1.2	0.3	-0.5
Hair Pigment	2.6	74.4	316.8	-5.1	7.2	-2.4	8.3	6.9	17.8	-1.9
Tanning	0.7	8.7	33.9	2.8	-3.0	0.4	-1.6	-2.1	-5.8	1.7
Hand grip strength (left)	3.0	8.0	16.7	-2.2	3.1	-4.0	4.1	-1.9	1.3	-1.7
Number of treatments/medications taken	0.7	1.2	2.8	1.6	-1.0	0.3	-0.6	1.2	0.7	1.7
Average weekly spirits intake	1.7	2.1	5.7	1.7	-0.4	0.1	0.3	2.4	1.3	2.0
Sensitivity / hurt feelings	0.5	0.8	2.6	0.1	1.6	-0.5	0.4	-1.0	1.0	0.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	0.3	0.5	1.0	-1.0	-1.1	-1.0	0.2
Hearing difficulty/problems: Yes	1.6	2.4	4.3	-1.5	-0.6	-0.7	1.2	-2.1	-2.0	-2.0
Relative age of first facial hair	0.2	0.3	2.1	-0.0	-0.0	0.3	-0.2	1.4	0.4	-0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.9	0.2	-0.0	-0.1	-0.7	0.9	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	-0.6	0.8	-0.3	0.6	-0.9	0.5	-0.4
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	-0.1	0.7	-0.7	0.9	-0.6	-0.1	-0.4
Systolic blood pressure, automated reading	2.0	5.9	13.2	3.0	-3.6	1.1	-1.6	3.0	-1.1	2.3
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	4.4	0.9	-0.7	1.6	-0.3	2.1	1.3	1.1
Angina	0.7	0.9	1.6	1.3	-1.2	0.3	-0.7	1.0	-0.8	1.2
Medication for hormone replacement therapy	0.7	0.8	4.2	0.3	-0.3	2.1	-0.8	-0.6	-0.5	0.4
Vitamin and mineral supplements	0.3	0.4	1.9	0.1	0.4	0.2	-0.2	1.4	0.8	0.2
Supplements: Zinc	4.7	5.1	11.0	-2.9	2.2	-0.4	1.8	-3.3	0.5	-2.8
Medication: Co-codamol	0.3	0.4	1.3	-0.2	-0.1	-0.3	1.0	-1.1	0.2	-0.3
Medication: Metformin	0.7	1.0	2.3	1.3	0.2	0.6	-0.6	1.2	-0.7	1.5
Diabetes (father)	1.6	2.0	8.2	-0.8	2.9	-0.1	-0.3	-1.6	1.3	-0.9
Diabetes (mother)	1.4	1.8	3.1	1.8	-1.7	0.2	-0.4	1.7	-1.0	1.7
Severe depression (siblings)	0.7	0.7	2.1	0.4	0.6	1.4	-1.4	-0.2	0.2	0.8
Pack years adult smoking proportion	0.5	0.7	2.0	-0.6	0.1	1.4	-1.4	-0.4	-0.3	-0.4
Impedance of leg (right)	2.4	11.8	36.0	3.3	-4.5	2.6	-6.0	0.7	-2.4	1.8
Leg fat-free mass (left)	4.6	24.5	82.8	-2.7	6.0	-5.8	9.1	-0.8	3.3	-0.9
Trunk fat percentage	0.7	2.9	8.4	0.9	0.9	0.7	0.5	2.6	2.9	1.6
Hand grip strength (right)	2.3	6.4	12.1	-2.3	2.6	-3.3	3.5	-2.3	0.3	-2.0
Townsend deprivation index at recruitment	0.9	1.3	4.1	0.3	-1.9	2.0	-0.4	0.2	-1.2	-0.2
Current tobacco smoking	0.1	0.2	1.0	-0.0	-0.3	1.0	0.4	-0.4	-0.2	-0.2
Average weekly fortified wine intake	0.6	0.7	1.6	-0.3	-0.6	0.9	-0.8	-1.3	-1.1	-0.7
Maternal smoking around birth	0.6	0.9	3.6	-0.2	0.1	-1.3	1.9	-0.9	-0.3	0.0
Fed-up feelings	0.6	1.1	2.3	1.3	0.6	1.4	-0.8	0.5	0.7	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	6.7	-0.9	2.2	2.6	-1.3	-0.9	1.0	-0.7
Relative age voice broke	0.4	0.6	1.3	-0.7	1.0	-1.1	0.8	0.8	-0.4	-0.4
Taking other prescription medications	0.8	1.3	3.1	1.0	-0.8	1.3	-1.8	0.7	1.1	1.0
Age when periods started (menarche)	0.1	0.3	0.6	-0.5	-0.3	-0.1	-0.8	0.4	0.7	-0.6
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	4.6	-1.1	2.1	0.5	0.1	-1.3	1.9	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	4.6	10.5	39.7	-2.8	2.5	-3.6	6.3	-1.9	-0.1	-1.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.1	-0.8	-0.1	0.3	0.7	-0.9	0.3
Qualifications: CSEs or equivalent	0.6	0.8	2.0	1.0	0.3	-1.4	0.9	0.2	-0.6	1.2
Serious illness, injury or assault to yourself	2.0	2.4	4.2	1.9	-1.9	1.5	-0.6	1.3	1.2	2.0
High blood pressure	0.2	0.5	2.1	0.2	-1.4	-1.1	-0.0	0.2	-0.4	-0.1
Hayfever, allergic rhinitis or eczema	1.2	2.6	7.6	-0.1	-0.8	-2.8	2.0	2.3	0.6	0.5
Multivitamins +/- minerals	0.3	0.4	0.8	-0.3	0.8	-0.7	0.9	-0.6	0.6	-0.0
Stomach or abdominal pain in last month	0.4	0.5	1.6	0.6	0.0	0.0	0.4	1.3	-0.6	0.8
Supplements: Glucosamine	0.4	0.6	1.8	-0.0	-0.7	1.0	1.3	-0.9	0.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.2	1.0	-1.1	0.5	0.1	-0.1	-1.5	0.8
Medication: Atenolol	0.5	0.7	1.2	1.1	-0.3	-0.7	0.7	1.0	0.5	1.1
Medication: Levothyroxine sodium	1.3	2.2	4.7	-0.8	-1.2	1.8	-2.2	-1.6	-1.1	-1.4
Sitting height	2.5	17.8	55.7	-2.0	4.4	-6.1	7.5	-1.3	2.4	-0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	-0.6	0.3	0.8	-0.4	0.0	0.0	-0.6
High blood pressure (mother)	1.2	1.7	5.8	2.1	0.5	0.3	-0.4	0.9	0.1	2.4
Body mass index (BMI)	0.9	3.7	8.8	-0.8	2.9	-0.3	2.6	1.2	3.0	0.5
Impedance of leg (left)	3.1	14.8	41.6	3.6	-5.2	3.3	-6.5	1.1	-2.6	1.9
Leg predicted mass (left)	4.6	24.4	82.5	-2.7	5.9	-5.8	9.1	-0.8	3.4	-0.9
Trunk fat mass	1.2	4.9	12.6	0.2	2.4	-1.1	2.9	2.2	3.5	1.3
Waist circumference	0.9	3.1	8.9	0.7	1.5	-0.1	1.6	2.3	3.0	1.6
Number of incorrect matches in round	0.5	0.8	2.0	-0.0	0.2	1.3	-1.0	0.9	1.4	-0.1
Past tobacco smoking	0.2	0.3	1.8	-0.0	0.1	-0.0	-1.4	0.4	0.3	-0.1
Alcohol usually taken with meals	0.9	1.5	4.5	-2.1	1.0	0.2	-0.0	-1.2	0.7	-1.7
Nervous feelings	0.3	0.6	2.6	-0.1	-0.3	0.5	-1.6	0.2	1.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	6.5	0.4	0.3	2.4	-2.5	0.3	0.2	0.5
Hearing difficulty/problems with background noise	1.1	1.8	3.6	-1.9	0.3	-1.4	1.2	-1.5	0.0	-1.8
Hair/balding pattern: Pattern 2	3.6	4.6	7.5	-2.7	2.5	-2.7	2.0	-1.5	0.9	-2.1
Had menopause	0.8	0.9	3.8	0.3	-2.0	-1.4	-0.3	0.8	0.2	-0.0
Had other major operations	0.4	0.5	1.7	-0.2	0.5	0.8	-1.3	0.6	0.9	-0.0
Forced vital capacity (FVC)	3.2	12.3	36.1	-1.3	3.8	-5.2	6.0	-2.3	0.9	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	5.3	12.2	46.6	-2.8	1.9	-3.7	6.8	-2.7	-1.0	-2.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	2.9	-0.0	-0.0	1.6	-1.7	0.4	1.3	0.1
Qualifications: None of the above	0.3	0.7	2.1	-0.2	-0.5	0.6	-0.6	1.4	1.4	-0.3
Financial difficulties in last 2 years	1.5	2.1	7.5	-0.0	-0.4	2.7	-2.3	-0.9	-0.3	-0.7
Mouth/teeth dental problems	0.5	0.7	2.4	-0.1	-0.4	-1.3	0.7	-0.6	-1.6	0.1
Heart attack	0.8	1.1	2.5	1.2	-0.9	-0.4	0.7	1.6	-0.6	1.3
Allergy	0.6	1.5	5.3	0.8	0.3	2.3	-1.6	-1.2	-0.4	0.5
Pain all over the body in last month	0.5	0.6	1.8	0.1	0.9	1.0	-0.3	-0.2	1.3	0.3
Diabetes (self-reported)	1.5	2.4	4.3	2.1	-1.6	0.6	-1.4	1.0	-1.8	1.8
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	7.5	1.3	-2.7	-0.9	-0.4	2.0	-0.4	1.3
Medication: Ramipril	0.3	0.3	0.9	0.8	-0.7	-0.4	-0.0	1.0	0.1	0.4
Medication: Simvastatin	1.1	1.7	4.4	0.7	-0.7	2.1	-2.0	1.0	-0.9	0.7
Fluid intelligence score	0.6	1.3	4.0	1.3	-0.0	-0.1	1.5	1.0	0.2	2.0
Illnesses of siblings	1.9	2.6	5.6	-1.8	2.2	-0.6	0.7	-2.4	1.0	-1.8
Neuroticism score	0.6	1.2	3.1	1.1	0.0	1.6	-1.8	-0.2	0.6	1.1
Weight	2.7	13.1	43.4	-1.4	4.4	-3.8	6.6	0.6	3.4	0.2
Impedance of arm (right)	0.8	3.8	13.9	1.5	-2.7	1.5	-3.7	0.5	-0.9	0.3
Arm fat percentage (right)	0.6	2.2	7.8	0.2	1.5	0.8	0.5	1.9	2.8	0.9
Trunk fat-free mass	4.4	25.2	89.5	-2.4	5.0	-6.8	9.5	-0.9	2.8	-0.7
Hip circumference	0.8	3.3	7.4	-0.8	2.2	-1.6	2.7	1.6	2.2	0.3
Time employed in main current job	0.7	0.8	3.0	0.8	-0.5	0.5	-1.7	0.9	0.1	0.9
Alcohol intake versus 10 years previously	1.2	1.8	5.4	0.9	-1.6	1.7	-2.3	0.6	-0.3	0.5
Father’s age at death	1.1	1.4	2.8	-1.4	1.2	-1.3	0.9	0.2	1.7	-1.1
Worrier / anxious feelings	1.1	2.1	6.3	-0.6	-0.0	1.8	-2.5	-1.7	-0.5	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.7	1.0	-0.4	1.1	-0.6	-0.9	-1.3	0.9
Falls in the last year	1.3	1.8	6.4	-0.0	-0.0	2.4	-2.5	0.0	0.8	0.0
Hair/balding pattern: Pattern 3	1.5	2.2	6.7	1.8	-2.6	0.7	-0.9	1.0	-1.1	1.4
Number of live births	0.4	0.5	1.6	0.3	-0.6	0.7	-1.3	-0.7	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1)	3.5	11.7	36.5	-1.4	3.9	-4.7	6.0	-2.2	0.9	-0.4
Pulse rate	1.3	2.2	3.8	-1.9	1.1	-0.4	1.0	-1.7	-1.5	-2.0
Happiness	1.6	1.9	5.1	-1.9	1.0	-0.5	0.2	-2.3	0.2	-1.9
Noisy workplace	1.2	1.5	5.4	0.3	-0.3	2.3	-2.1	0.0	0.5	0.2
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.3	-1.2	1.5	-0.4	1.0	-0.2	0.5	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.8	-0.7	0.9	-0.1	0.1	-0.1	-0.7	-0.5
Mouth/teeth dental problems: Dentures	0.7	1.2	4.1	-0.1	0.1	2.0	-1.2	1.3	1.1	-0.2
Asthma	0.5	0.9	2.5	-1.5	0.3	-0.7	-0.3	-0.7	0.6	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	6.4	-0.7	0.6	1.2	-0.1	-2.5	-0.4	-0.8
Medication: Cholesterol lowering	0.9	1.4	3.1	1.5	-0.9	0.8	-1.8	1.1	-0.3	1.4
Depression (self-reported)	0.7	0.8	1.7	-1.2	-0.3	-0.7	0.3	-1.2	0.4	-1.3
Medication: Lansoprazole	0.9	1.0	2.3	1.1	-0.2	0.6	0.2	1.5	1.0	1.5
Prospective memory result	1.2	1.5	3.9	2.0	-0.9	0.4	-1.1	1.2	-0.1	1.8
Lung cancer (father)	1.1	1.3	3.7	-1.9	0.3	-0.2	0.1	-1.4	0.2	-1.7
Illnesses of mother	2.3	2.8	7.0	-2.6	0.9	-0.5	1.0	-2.1	0.7	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	3.2	10.3	33.3	-1.4	3.2	-4.5	5.8	-2.0	1.3	-0.6
Pulse wave Arterial Stiffness index	0.3	0.3	1.4	-0.2	1.2	-0.3	0.0	-0.7	0.5	-0.1
Impedance of arm (left)	0.9	4.2	11.6	1.6	-2.8	1.9	-3.4	1.0	-1.4	0.6
Arm fat mass (right)	1.3	5.3	12.3	-0.7	3.1	-1.3	3.5	1.3	3.3	0.6
Trunk predicted mass	4.4	25.2	89.9	-2.4	5.0	-6.8	9.5	-0.9	2.8	-0.7
Standing height	2.6	25.9	90.6	-2.0	4.0	-8.1	9.5	-1.8	1.3	-1.0
Length of working week for main job	1.4	1.5	3.3	-1.4	1.8	-0.6	0.6	-1.5	1.0	-1.1
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.0	-0.2	0.8	-0.6	0.2	0.7	-0.3
Breastfed as a baby	0.2	0.3	1.7	0.1	-0.1	1.3	-0.0	-0.3	-0.1	0.3
Tense / ‘highly strung’	0.3	0.5	3.0	0.2	-0.2	0.6	-1.7	-0.1	0.2	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.2	-1.5	1.8	0.8	-0.4	-1.8	0.1	-1.2
Hair/balding pattern: Pattern 4	0.3	0.8	3.9	-0.5	2.0	0.9	0.2	-0.6	0.5	-0.3
Birth weight of first child	1.5	2.8	10.4	0.4	0.3	-3.2	2.8	-0.0	0.1	0.9
Peak expiratory flow (PEF)	2.4	5.6	18.7	-1.0	2.0	-3.3	4.3	-2.0	-0.3	-0.2
Pulse wave reflection index	0.8	0.9	3.7	0.5	0.8	-0.4	0.4	0.7	1.9	1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.4	-0.3	0.3	1.8	-0.5	0.4	1.0	-0.3
Loud music exposure frequency	1.1	1.2	4.0	-0.9	1.4	2.0	-0.8	-0.7	-0.2	-0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	0.4	-0.2	-0.7	-0.5	-0.6	-0.9	-0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	0.1	-0.1	-0.2	-0.9	-0.8	-0.7	-0.2
Blood clot in the leg (DVT)	0.8	1.0	4.1	-0.5	0.6	-0.9	0.4	-2.0	-0.6	-0.9
Medication: Paracetamol	0.2	0.4	0.9	0.8	-0.4	0.4	-1.0	-0.6	-0.1	0.6
Headache pain in last month	0.8	1.3	4.1	0.2	0.8	2.0	-2.0	-0.3	-0.8	0.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	2.9	-1.7	0.6	-0.6	1.4	-1.6	-0.4	-1.7
Glaucoma (self-reported)	0.9	1.0	3.0	-1.7	0.9	0.7	-0.1	-0.9	0.7	-1.3
Gout (self-reported)	0.6	0.8	2.2	-0.5	0.9	-1.5	0.5	0.7	1.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.9	-0.1	-1.2	1.0	-2.2	-1.4	-1.5	-0.5
Medication: Amlodipine	1.1	1.5	4.0	1.2	-0.9	-2.0	0.9	1.2	0.7	1.3
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	-0.3	-0.1	-0.6	0.6	0.7	-0.2	-0.1
Birth weight	0.6	1.4	3.9	-0.7	1.1	-2.0	1.7	0.5	1.0	-0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.2	0.8	-1.0	-0.4	-0.7	1.1	-0.8	0.7
High blood pressure (siblings)	1.4	2.0	3.4	1.8	-1.9	-0.3	-1.5	0.9	-0.8	1.8
Forced vital capacity (FVC), Best measure	2.9	10.7	33.5	-1.2	3.2	-5.0	5.8	-1.9	1.0	-0.4
Body fat percentage	0.8	3.1	7.8	1.1	0.6	1.4	-0.2	2.7	2.8	1.8
Leg fat percentage (right)	0.8	3.0	7.5	1.4	0.0	1.5	-1.2	2.7	2.1	1.9
Arm fat-free mass (right)	3.8	19.5	73.8	-1.5	4.6	-5.5	8.6	-0.1	3.0	0.1
Exposure to tobacco smoke outside home	0.4	0.5	1.1	0.9	-0.6	0.5	0.5	-0.5	-1.1	0.8
Comparative body size at age 10	1.0	2.8	7.2	-0.9	2.7	-1.4	2.3	0.1	2.1	0.2
Number of full brothers	1.0	1.2	2.9	0.2	-0.6	1.7	-1.6	1.2	1.0	0.4
Worry too long after embarrassment	1.2	2.0	4.2	1.6	-0.9	1.2	-2.1	-0.2	-1.3	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.9	0.5	0.2	1.4	-0.8	-0.3	0.1	0.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	0.4	-0.4	0.6	-0.6	0.6	0.9	0.6
Number of children fathered	1.3	1.5	4.5	-1.1	-0.5	-1.8	2.1	-0.6	-0.3	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.2	0.7	1.8	-0.4	0.8	0.0	0.7	1.1
Age at first live birth	0.4	0.8	3.1	-0.5	0.2	-1.8	1.1	-0.8	0.3	-0.2
Pulse wave peak to peak time	0.2	0.3	0.9	0.2	-1.0	-0.3	0.5	0.7	-0.5	0.1
Health satisfaction	0.3	0.4	0.6	-0.8	0.5	-0.4	-0.6	-0.6	-0.7	-0.8
Shortness of breath walking on level ground	0.2	0.3	0.8	0.3	0.4	0.9	-0.7	-0.2	0.2	0.6
Qualifications: College or University degree	0.1	0.4	1.0	0.1	0.4	-0.6	0.7	-0.4	-1.0	0.8
Eye problems/disorders: None of the above	0.6	0.7	2.2	0.5	-1.3	0.3	-1.5	-0.1	-0.4	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	0.2	0.2	0.5	0.0	-0.6	-0.6	0.2
Emphysema/chronic bronchitis	0.3	0.3	1.0	-0.3	-0.3	-0.5	0.6	1.0	0.7	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	-0.9	0.5	0.2	-0.6	-0.1	0.2	-1.0
Neck or shoulder pain in last month	0.7	1.0	2.2	-0.3	-1.5	-1.0	1.2	-0.5	-1.1	-0.7
Medication: Blood pressure	1.0	1.7	4.3	2.1	-1.1	-0.4	-0.7	1.4	-0.0	2.0
Angina (self-reported)	0.4	0.5	0.9	0.9	-0.9	0.1	-0.6	0.5	-0.7	0.7
Migraine (self-reported)	0.4	0.5	1.3	-0.4	0.9	0.6	-0.4	-0.5	1.1	-0.6
Medication: Ibuprofen	2.2	2.6	9.9	-1.5	1.0	1.6	-0.4	-3.1	-0.2	-1.5
Medication: Allopurinol	0.4	0.6	1.4	-0.4	0.8	0.6	-1.2	-0.4	1.1	-0.3
Medication: Omeprazole	3.9	4.7	15.0	2.1	-1.7	0.8	-0.3	3.9	1.7	2.6
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.1	-0.4	-0.7	0.5	0.5	0.3	0.2
Mean time to correctly identify matches	0.7	1.4	5.9	0.2	-2.4	1.1	-0.7	1.5	-0.1	-0.3
Heart disease (mother)	0.9	1.0	1.7	1.3	-1.0	0.9	-1.1	0.7	-0.7	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	3.2	0.8	-0.3	-0.2	-0.1	1.8	0.6	0.8
Whole body fat mass	1.1	4.4	11.4	0.2	2.5	-0.9	2.7	1.9	3.4	1.3
Leg fat mass (right)	0.9	3.6	8.2	0.4	2.1	-0.9	2.4	1.9	2.9	1.5
Arm predicted mass (right)	3.5	17.8	68.4	-1.4	4.5	-5.1	8.3	-0.0	2.9	0.3
Pulse rate, automated reading	2.2	7.0	14.7	-3.8	3.8	-1.0	2.5	-1.6	1.0	-3.0
Alcohol intake frequency.	0.7	1.7	4.2	0.6	0.2	1.5	-2.0	1.5	1.6	0.1
Comparative height size at age 10	2.0	11.1	37.3	-1.9	1.9	-4.9	6.1	-1.4	2.1	-1.6
Number of full sisters	1.0	1.2	3.4	-1.0	-0.7	1.9	-1.3	0.2	-0.5	-1.2
Suffer from ‘nerves’	0.2	0.3	0.6	0.2	0.6	-0.3	-0.6	0.6	0.8	0.1
Overall health rating	0.4	0.9	1.6	1.3	-0.4	1.1	-1.2	0.9	0.2	1.2
Chest pain or discomfort	0.6	0.9	2.4	-0.2	0.2	1.4	-1.6	-1.1	-0.8	-0.4
Had major operations	2.1	2.5	4.7	1.2	-2.0	2.2	-1.8	0.3	-1.7	1.1
Age at last live birth	0.8	1.2	3.3	1.6	-0.8	0.0	-0.8	0.6	-0.9	1.8
Family relationship satisfaction	0.6	0.7	4.1	-0.5	0.1	0.3	-0.4	-0.2	-2.0	-0.5
Leg pain on walking	0.6	0.7	2.6	0.5	1.6	0.8	-0.3	0.4	0.7	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	-0.1	-0.0	0.6	-1.4	-1.0	0.2	-0.8
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.8	1.2	0.1	-0.2	-1.3	0.5	0.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.8	0.5	-0.5	-1.1	1.4	-0.1	-0.4	0.4
Medication: Aspirin	1.4	1.8	3.9	1.1	-0.4	-2.0	1.9	1.4	-0.0	1.5
Supplements: Vitamin C	1.3	1.5	2.5	-1.1	-1.5	-0.9	0.8	-1.3	-1.1	-1.6
Knee pain experienced in last month	0.7	1.0	2.4	1.0	-1.6	1.1	-0.6	0.4	-1.1	1.1
Hypertension (Self-reported)	0.3	0.7	3.2	0.4	-1.8	-1.0	-0.1	0.4	-0.5	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-0.2	-0.4	1.0	0.7	1.1	0.8	0.3
Illnesses of father: Heart disease	0.8	1.1	2.7	0.3	-0.2	1.5	-1.3	1.7	0.3	0.8
Illnesses of siblings: Diabetes	2.0	2.5	7.0	1.6	-2.1	-0.1	-0.2	1.1	-2.6	1.5
Smoking status: Previous	0.1	0.2	1.2	-0.0	0.0	-0.3	1.1	-0.1	0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.7	15.4	-0.4	1.9	-3.5	3.9	-1.1	0.0	-0.1
Whole body fat-free mass	4.5	25.8	91.0	-2.6	5.5	-6.5	9.5	-0.9	3.1	-0.8
Leg fat-free mass (right)	4.3	23.1	81.0	-2.6	5.7	-5.5	9.0	-0.7	3.0	-0.9
Arm fat percentage (left)	0.7	2.7	7.6	0.5	1.5	0.9	0.7	2.4	2.8	1.3
Average weekly red wine intake	1.4	2.1	6.0	-1.9	0.7	-0.3	1.2	-2.5	-0.4	-1.7
Handedness (chirality/laterality): Left-handed	2.4	2.9	5.6	-2.4	1.2	-2.3	1.0	-1.4	-0.7	-2.2
Mood swings	0.9	1.6	4.2	1.3	0.4	2.0	-0.9	0.6	1.2	1.6
Loneliness, isolation	0.7	1.0	2.2	1.2	0.9	1.5	-1.1	0.1	-0.0	1.2
Long-standing illness, disability or infirmity	0.3	0.5	1.3	0.4	-0.6	0.9	-1.1	-0.2	0.7	0.4
Ever had bowel cancer screening	2.2	2.6	12.0	1.0	-3.5	0.7	-0.7	1.4	-1.5	0.6
Diabetes diagnosed by doctor	1.9	3.1	5.8	2.4	-1.6	0.5	-1.5	1.7	-1.7	2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.7	-1.0	1.3	0.1	0.6	-0.6	-0.7	-1.1
Friendships satisfaction	1.6	2.0	5.2	-2.0	-0.0	-0.6	0.4	-2.3	-0.3	-2.0
Qualifications: nursing, teaching	0.4	0.7	2.3	0.3	0.8	-0.6	1.5	-0.2	-0.8	0.7
Commuting to job workplace: Walk	1.0	1.1	2.4	-1.5	1.2	-0.4	1.3	-0.3	0.1	-1.4
Eye problems/disorders: Cataract	1.3	1.5	5.3	-0.3	1.5	-2.3	1.7	-0.3	-0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	7.0	-1.2	1.0	0.0	0.7	-0.1	2.7	-1.0
Medication for cholesterol	0.2	0.3	1.4	-0.1	0.4	-1.2	0.6	0.1	-0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.9	-1.4	-0.5	-0.2	0.8	-1.9	-0.6	-2.0
Back pain experienced in last month	0.5	0.7	2.3	1.2	0.0	-0.5	0.6	0.7	0.6	1.5
Mineral and other dietary supplements	0.6	0.7	3.2	-0.1	1.8	1.2	-0.5	-0.5	0.3	0.0
Breast cancer (self-reported)	0.9	1.0	1.8	1.0	-0.5	-1.2	1.3	0.7	1.0	1.1
Asthma (self-reported)	0.5	0.9	2.2	-1.5	0.5	-0.7	-0.3	-0.5	0.9	-1.5
Osteoporosis (self-reported)	5.3	6.5	22.5	2.5	-1.3	2.9	-4.7	1.8	0.8	1.7
Osteoarthritis (self-reported)	0.2	0.2	0.7	-0.5	-0.4	0.3	0.8	0.0	0.5	-0.3
Medication: Aspirin	1.8	2.3	4.1	1.6	-0.7	-1.8	1.6	1.9	-0.2	2.0
Medication: Gliclazide	0.6	0.7	2.1	0.6	0.4	1.4	-1.4	0.3	-0.6	0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	2.7	0.0	-0.4	-0.3	0.1	-1.6	-0.9	-0.4
Smoking status: Current	0.2	0.3	0.7	-0.1	-0.3	0.8	0.5	-0.7	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	5.5	0.2	1.8	-1.0	2.3	-0.1	0.7	0.9
Whole body water mass	4.6	26.0	91.8	-2.7	5.6	-6.4	9.6	-0.9	3.1	-0.9
Leg predicted mass (right)	4.4	23.7	83.0	-2.8	5.8	-5.5	9.1	-0.7	3.1	-1.0
Arm fat mass (left)	1.3	5.5	12.4	-0.5	3.0	-1.2	3.5	1.7	3.5	0.8
Number of self-reported non-cancer illnesses	0.2	0.4	1.3	-0.5	-1.1	-0.0	0.1	-0.0	0.9	-0.7
Average weekly champagne plus white wine intake	0.5	0.7	3.5	-0.4	-0.2	-0.8	1.9	-0.7	0.4	-0.4
Miserableness	0.5	1.0	3.5	0.1	0.2	1.9	-1.6	-0.1	0.6	0.4
Guilty feelings	0.6	0.9	2.2	1.1	-0.5	0.9	-1.5	-0.7	-0.2	1.1
Wears glasses or contact lenses	1.1	1.2	5.1	-0.4	-2.3	0.2	-1.7	0.5	-0.1	-0.5
Ever taken oral contraceptive pill	0.8	0.9	2.8	-0.1	0.6	1.0	-1.7	-1.0	-0.9	-0.4
Hearing aid user	0.7	0.8	1.7	-1.0	0.4	-0.1	1.0	-1.3	-0.7	-1.1
Mother’s age at death	0.4	0.5	1.1	-1.1	0.9	-0.7	0.4	0.1	0.7	-0.8
Financial situation satisfaction	0.4	0.4	1.3	0.2	0.7	1.1	-0.4	-1.0	-0.1	-0.1
Tinnitus: Yes, now most or all of the time	1.9	2.2	8.8	0.6	-2.1	-1.1	0.6	-0.5	-3.0	-0.1
Commuting to job workplace: Public transport	0.9	1.1	3.6	-1.1	-0.8	-0.0	0.5	-0.8	-1.9	-1.1
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	-0.8	0.1	0.9	-0.2	0.5	0.6	-0.4
Medication: Blood pressure	0.0	0.1	0.3	0.2	-0.5	-0.1	-0.1	0.2	0.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	1.0	-0.8	-0.5	-0.4	0.2	0.1	0.7
Supplements: Fish oil (including cod liver oil)	1.6	2.1	5.1	0.8	-2.3	-1.9	0.6	1.6	-1.5	0.7
High cholesterol (Self-reported)	0.6	1.0	2.1	0.4	-0.9	1.2	-1.5	1.4	0.4	0.6
Medication: Bendroflumethiazide	0.5	0.8	1.7	1.1	-1.2	-0.4	-0.1	1.3	0.4	1.0
Medication: Paracetamol	0.3	0.5	2.2	0.4	-0.3	0.6	-1.5	-0.3	0.7	0.4
Medication: Lisinopril	0.3	0.4	1.4	0.6	1.2	-0.1	-0.6	0.4	0.3	0.6
Medication: Atorvastatin	0.5	0.6	1.3	1.1	-0.4	0.3	-0.9	1.0	0.1	1.1
Illnesses of father: High blood pressure	0.3	0.4	0.7	0.8	-0.0	-0.7	0.2	0.8	-0.2	0.8
Alcohol drinker status: Never	1.2	1.5	2.6	1.5	-1.6	0.7	-1.2	1.5	0.8	0.9
Ever smoked	0.3	0.5	1.4	0.7	0.1	0.2	1.2	0.0	-0.1	1.1
Basal metabolic rate	4.1	23.0	81.2	-2.4	5.3	-5.9	9.0	-0.6	3.2	-0.6
Leg fat percentage (left)	0.9	3.3	8.5	1.3	-0.1	1.9	-1.3	2.9	2.1	1.8
Arm fat-free mass (left)	3.8	19.2	68.6	-1.9	4.6	-5.5	8.3	-0.4	3.2	-0.3
Number of operations (self-reported)	0.4	0.6	1.8	-0.3	-1.2	-0.7	-0.3	-0.4	-1.3	-0.3
Average weekly beer plus cider intake	1.6	2.3	4.9	-2.2	1.0	-0.8	1.0	-2.0	-0.2	-2.2
Irritability	0.3	0.6	1.3	1.2	-0.4	1.1	-0.3	0.2	0.4	1.1
Risk taking	1.3	1.9	6.9	-0.4	1.3	-0.3	2.6	0.6	2.0	0.5
Ever had prostate specific antigen (PSA) test	0.5	0.5	2.3	0.0	-0.2	0.1	-0.9	1.5	0.7	0.5
Fractured/broken bones in last 5 years	0.7	0.8	3.5	-0.2	-0.6	1.4	-1.9	-0.1	0.2	-0.4
Age started oral contraceptive pill	0.4	0.6	1.5	-0.2	-0.1	0.7	-1.2	0.9	1.0	-0.0
Diastolic blood pressure, automated reading	0.2	0.6	1.2	0.8	0.3	0.2	0.0	1.1	1.1	1.1
Ever depressed for a whole week	0.5	0.6	2.6	0.4	-0.3	1.6	-0.7	0.2	0.8	0.6
Unable to work because of sickness or disability	0.4	0.5	1.2	-0.6	1.1	0.1	-0.5	-0.7	1.1	-0.2
Commuting to job workplace: Cycle	1.1	1.4	4.0	-0.5	-0.8	-1.2	2.0	0.6	1.6	-0.4
Myopia	0.5	0.7	1.6	-0.3	1.1	-0.9	1.1	-1.3	-0.4	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.4	2.1	-0.6	1.5	0.3	0.5	-0.1	0.1	-0.1
Cholesterol lowering medication	1.0	1.5	3.2	1.2	-1.0	1.8	-0.5	1.7	0.1	1.4
Medication: Omeprazole (e.g. Zanprol)	4.8	5.9	17.6	2.8	-1.9	0.8	-0.2	4.2	1.2	3.1
Pain experienced in last month	1.1	1.8	3.1	-1.8	1.3	-1.7	1.1	-0.1	1.1	-1.5
Supplements: Calcium	0.9	1.0	2.0	1.3	-0.5	-0.4	-0.2	1.2	1.2	1.4
Basal cell carcinoma (self-reported)	1.7	2.0	7.2	-0.7	-0.2	-2.7	2.4	0.3	0.7	-0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.5	1.1	-0.7	-0.5	0.7	1.6	-0.3	1.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	3.1	-0.2	0.6	-0.9	0.2	-1.8	-0.6	-0.6
Heart disease (siblings)	0.2	0.2	0.6	-0.1	0.4	0.5	0.1	0.7	0.7	0.2
Alcohol drinker status: Previous	3.0	3.4	8.4	-2.5	1.1	-0.2	-0.7	-2.5	0.9	-2.9
Pack years of smoking	0.3	0.4	1.1	-0.6	0.1	1.0	-1.1	-0.2	-0.1	-0.4
Impedance of whole body	2.0	10.1	27.7	2.9	-4.3	2.9	-5.3	1.3	-2.0	1.5
Leg fat mass (left)	0.9	3.6	8.2	0.5	1.9	-0.7	2.4	2.1	2.9	1.6
Arm predicted mass (left)	3.7	18.8	68.6	-1.9	4.5	-5.4	8.3	-0.6	3.1	-0.3