Best TWAS P=1.21e-27 · Best GWAS P=2e-38 conditioned to 7.25e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RBBP5 | 0.15 | 0.07 | bslmm | 617 | 0.10 | 2.3e-12 | -10.8 | -10.7 | 1.6e-26 | 0.68 | 0.93 | 0.07 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | TMEM81 | 0.07 | 0.04 | lasso | 5 | 0.03 | 6.4e-05 | -6.9 | -7.0 | 1.8e-12 | 0.41 | 0.84 | 0.06 | FALSE |
| 3 | GTEx | Artery Tibial | TMCC2 | 0.36 | 0.14 | lasso | 5 | 0.26 | 2.3e-20 | 3.7 | -5.2 | 1.8e-07 | 0.15 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Brain Cerebellum | RBBP5 | 0.19 | 0.03 | enet | 6 | 0.00 | 3.9e-01 | 4.0 | -6.2 | 4.0e-10 | 0.38 | 0.12 | 0.08 | FALSE |
| 5 | GTEx | Brain Cerebellum | TMEM81 | 0.25 | 0.02 | enet | 21 | 0.11 | 3.0e-04 | -10.2 | -8.4 | 3.0e-17 | 0.68 | 0.04 | 0.84 | FALSE |
| 6 | GTEx | Brain Nucleus accumbens basal ganglia | RBBP5 | 0.25 | 0.00 | enet | 16 | 0.04 | 3.5e-02 | 2.8 | -7.8 | 6.2e-15 | 0.60 | 0.04 | 0.69 | FALSE |
| 7 | GTEx | Muscle Skeletal | TMCC2 | 0.04 | 0.04 | lasso | 1 | 0.03 | 4.4e-04 | -8.1 | 8.1 | 5.5e-16 | -0.39 | 0.46 | 0.31 | FALSE |
| 8 | GTEx | Thyroid | RBBP5 | 0.05 | 0.02 | enet | 8 | 0.04 | 2.9e-04 | -8.1 | -7.2 | 4.1e-13 | 0.33 | 0.60 | 0.06 | FALSE |
| 9 | METSIM | Adipose | TMEM81 | 0.03 | 0.01 | blup | 584 | 0.01 | 5.0e-03 | 3.7 | -6.7 | 2.4e-11 | 0.42 | 0.65 | 0.06 | FALSE |
| 10 | NTR | Blood | TMCC2 | 0.01 | 0.00 | blup | 582 | 0.00 | 1.3e-02 | 3.8 | -5.2 | 2.1e-07 | 0.35 | 0.27 | 0.03 | FALSE |
| 11 | YFS | Blood | TMCC2 | 0.03 | 0.02 | blup | 582 | 0.02 | 2.5e-06 | 3.8 | -6.2 | 5.1e-10 | 0.49 | 0.90 | 0.10 | FALSE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CNTN2 | 0.04 | 0.02 | enet | 8 | 0.02 | 1.3e-02 | -11.4 | -10.7 | 1.0e-26 | 0.77 | 0.01 | 0.91 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DSTYK | 0.02 | 0.01 | enet | 6 | 0.01 | 1.3e-02 | -7.1 | 7.1 | 1.1e-12 | -0.41 | 0.19 | 0.03 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CNTN2 | 0.03 | 0.01 | blup | 98 | 0.01 | 8.7e-03 | -5.0 | -7.0 | 2.4e-12 | 0.56 | 0.01 | 0.75 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DSTYK | 0.05 | 0.04 | blup | 67 | 0.07 | 6.2e-08 | 3.9 | 5.9 | 3.0e-09 | -0.34 | 0.99 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMEM81 | 0.10 | 0.05 | lasso | 3 | 0.06 | 6.0e-07 | 4.7 | -7.9 | 2.2e-15 | 0.56 | 0.18 | 0.82 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | RBBP5 | 0.03 | 0.01 | blup | 79 | 0.02 | 1.2e-03 | 4.0 | -8.7 | 4.3e-18 | 0.65 | 0.08 | 0.49 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DSTYK | 0.06 | 0.00 | blup | 67 | 0.02 | 1.2e-03 | 2.5 | -5.5 | 3.2e-08 | 0.37 | 0.04 | 0.12 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CNTN2 | 0.09 | 0.04 | enet | 16 | 0.07 | 3.8e-08 | -10.8 | -9.5 | 1.9e-21 | 0.65 | 0.07 | 0.93 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RBBP5 | 0.03 | 0.02 | lasso | 2 | 0.03 | 2.7e-04 | 3.9 | -5.7 | 9.4e-09 | 0.34 | 0.36 | 0.11 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | CNTN2 | 0.14 | 0.03 | blup | 98 | 0.11 | 1.0e-10 | -5.5 | -8.1 | 4.0e-16 | 0.57 | 0.28 | 0.72 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | RBBP5 | 0.09 | 0.04 | blup | 80 | 0.05 | 4.8e-06 | -10.9 | -10.9 | 1.2e-27 | 0.70 | 0.03 | 0.96 | TRUE |