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chr1:154,282,146-156,450,740

Best TWAS P=3.92e-18 · Best GWAS P=3.68e-18 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FDPS	0.04	0.04	lasso	2	0.04	3.3e-05	5.7	-5.7	1.1e-08	-0.04	0.86	0.02	FALSE
2	CommonMind	Brain Pre-frontal Cortex	YY1AP1	0.35	0.52	bslmm	291	0.52	1.4e-73	5.4	5.3	1.1e-07	0.04	0.10	0.90	FALSE
3	GTEx	Adrenal Gland	HCN3	0.13	0.09	lasso	2	0.05	7.1e-03	5.4	-5.4	5.7e-08	-0.05	0.12	0.06	FALSE
4	GTEx	Artery Coronary	ASH1L	0.15	-0.01	enet	25	0.00	5.1e-01	5.5	-5.4	6.3e-08	0.16	0.08	0.06	FALSE
5	GTEx	Artery Coronary	HCN3	0.17	-0.01	lasso	6	-0.01	7.4e-01	5.5	-5.3	9.1e-08	-0.06	0.05	0.16	FALSE
6	GTEx	Brain Cerebellar Hemisphere	DCST2	0.45	0.10	lasso	6	0.16	6.6e-05	3.7	-7.1	9.8e-13	0.75	0.01	0.96	FALSE
7	GTEx	Brain Putamen basal ganglia	FAM189B	0.34	0.01	lasso	4	0.01	1.7e-01	5.4	-5.8	6.3e-09	-0.05	0.09	0.05	FALSE
8	GTEx	Breast Mammary Tissue (Male)	FAM189B	0.21	0.00	lasso	7	-0.01	6.3e-01	5.8	-5.9	4.3e-09	-0.01	0.05	0.11	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	ADAM15	0.18	0.00	lasso	4	-0.01	7.4e-01	5.5	-5.3	1.2e-07	-0.09	0.08	0.06	FALSE
10	GTEx	Cells Transformed fibroblasts	HCN3	0.05	0.05	lasso	5	0.06	3.8e-05	5.3	-5.5	3.8e-08	-0.02	0.88	0.00	FALSE
11	GTEx	Colon Transverse	GBA	0.06	0.09	enet	8	0.08	7.9e-05	5.7	-5.6	2.3e-08	0.05	0.65	0.02	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	GBA	0.13	0.12	lasso	6	0.11	8.7e-05	5.4	-5.6	1.9e-08	-0.07	0.58	0.02	FALSE
13	GTEx	Esophagus Mucosa	GBA	0.28	0.30	enet	26	0.34	4.2e-23	5.9	-5.8	7.9e-09	0.03	1.00	0.00	FALSE
14	GTEx	Lung	HCN3	0.08	0.01	lasso	5	0.00	3.4e-01	5.5	-5.4	7.7e-08	-0.08	0.14	0.03	FALSE
15	GTEx	Muscle Skeletal	MSTO2P	0.07	0.05	lasso	2	0.05	1.1e-05	5.7	-5.3	1.0e-07	-0.03	0.02	0.97	FALSE
16	GTEx	Nerve Tibial	HCN3	0.17	0.28	lasso	6	0.25	5.8e-18	5.3	-5.6	2.3e-08	-0.02	1.00	0.00	FALSE
17	GTEx	Nerve Tibial	RUSC1	0.08	0.10	lasso	5	0.09	8.9e-07	5.8	-5.3	9.2e-08	0.02	0.91	0.00	FALSE
18	GTEx	Pancreas	THBS3	0.36	0.14	lasso	6	0.12	1.0e-05	-4.0	5.4	6.7e-08	-0.34	0.18	0.53	FALSE
19	GTEx	Pancreas	RP11-263K19.4	0.22	0.06	enet	23	0.05	3.1e-03	-4.0	5.1	2.7e-07	-0.43	0.06	0.49	FALSE
20	GTEx	Skin Sun Exposed Lower leg	ADAM15	0.14	0.09	lasso	4	0.08	6.1e-07	-8.7	8.2	2.1e-16	-0.96	0.00	1.00	FALSE
21	GTEx	Stomach	GBAP1	0.09	0.12	lasso	3	0.13	1.2e-06	-3.8	-5.2	1.5e-07	0.04	0.87	0.02	FALSE
22	GTEx	Stomach	MTX1P1	0.22	-0.01	lasso	4	0.01	1.7e-01	5.4	-6.2	7.1e-10	0.07	0.03	0.18	TRUE
23	GTEx	Thyroid	DAP3	0.11	0.04	lasso	9	0.04	8.9e-04	5.3	-5.6	2.6e-08	-0.01	0.03	0.93	FALSE
24	GTEx	Thyroid	HCN3	0.05	0.05	lasso	1	0.04	5.2e-04	5.4	-5.4	6.7e-08	-0.02	0.29	0.07	FALSE
25	GTEx	Thyroid	FAM189B	0.08	0.10	lasso	2	0.11	5.3e-09	4.7	-5.2	2.0e-07	-0.04	1.00	0.00	FALSE
26	GTEx	Whole Blood	GBA	0.07	0.11	lasso	4	0.09	1.2e-08	5.8	5.8	5.7e-09	-0.02	1.00	0.00	FALSE
27	NTR	Blood	ZBTB7B	0.02	0.02	lasso	1	0.01	5.4e-05	-5.5	-5.5	3.9e-08	0.67	0.87	0.03	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBA	0.03	0.00	blup	26	0.02	3.1e-04	5.3	-5.2	2.3e-07	0.03	0.02	0.82	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	LENEP	0.01	0.00	blup	37	0.01	1.6e-03	3.5	-5.7	9.7e-09	0.48	0.02	0.30	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCST2	0.04	0.01	blup	50	0.03	2.0e-04	3.1	5.5	3.3e-08	-0.37	0.22	0.10	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADAM15	0.18	0.04	blup	49	0.06	2.4e-07	-3.5	-5.9	3.5e-09	0.09	0.17	0.03	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GBA	0.04	0.01	blup	26	0.01	8.3e-03	4.7	-5.2	2.0e-07	-0.05	0.01	0.65	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HCN3	0.03	0.03	lasso	1	0.03	2.3e-04	5.7	-5.7	1.1e-08	-0.03	0.01	0.97	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GBA	0.02	0.00	blup	27	0.01	1.2e-02	5.5	-5.4	6.5e-08	-0.04	0.01	0.49	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZBTB7B	0.05	0.06	lasso	2	0.05	1.8e-06	-8.7	8.7	3.9e-18	-1.00	0.00	1.00	TRUE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	FDPS	0.02	0.02	lasso	2	0.01	1.6e-02	5.5	-5.5	3.4e-08	-0.01	0.01	0.66	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	MSTO1	0.03	0.03	blup	6	0.03	2.1e-04	5.4	-5.2	1.5e-07	-0.04	0.00	0.98	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	MSTO2P	0.04	0.00	enet	9	0.02	4.2e-03	4.6	-5.8	7.1e-09	0.06	0.00	0.16	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	C1orf104	0.03	0.00	blup	21	0.02	3.7e-03	5.4	5.8	6.3e-09	-0.04	0.01	0.49	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	FDPS	0.16	0.17	enet	7	0.18	1.2e-17	5.4	5.6	1.7e-08	0.01	0.01	0.99	FALSE