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chr2:197,134,790-200,117,777

Best TWAS P=9.31e-22 · Best GWAS P=6.78e-20 conditioned to 0.00234

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SF3B1	0.06	0.07	enet	10	0.07	2.5e-09	8.85	8.8	8.8e-19	0.51	0.05	0.95	FALSE
2	GTEx	Adipose Subcutaneous	RFTN2	0.14	0.10	enet	11	0.13	5.3e-11	9.06	7.3	2.3e-13	0.91	0.02	0.98	FALSE
3	GTEx	Adrenal Gland	ANKRD44	0.15	0.05	lasso	5	0.15	3.9e-06	-0.69	-6.0	1.7e-09	-0.41	0.09	0.77	FALSE
4	GTEx	Breast Mammary Tissue	SF3B1	0.06	0.06	lasso	4	0.03	6.6e-03	8.78	9.4	3.2e-21	0.64	0.08	0.85	FALSE
5	GTEx	Breast Mammary Tissue (Female)	SF3B1	0.05	-0.01	lasso	3	-0.01	8.1e-01	8.85	9.4	4.1e-21	0.68	0.04	0.26	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	MARS2	0.15	0.14	lasso	4	0.07	2.6e-03	-7.86	-7.5	4.9e-14	-0.70	0.09	0.55	FALSE
7	GTEx	Colon Transverse	MARS2	0.17	0.12	lasso	4	0.13	7.4e-07	-7.86	-7.0	3.5e-12	-0.63	0.26	0.38	FALSE
8	GTEx	Esophagus Mucosa	SF3B1	0.04	0.02	lasso	4	0.01	5.7e-02	8.59	8.7	4.6e-18	0.51	0.09	0.74	FALSE
9	GTEx	Esophagus Muscularis	SF3B1	0.06	0.02	lasso	4	0.03	1.0e-02	8.11	7.6	4.0e-14	0.45	0.11	0.48	FALSE
10	GTEx	Lung	SF3B1	0.06	0.04	enet	23	0.02	2.2e-02	8.59	7.1	1.1e-12	0.48	0.07	0.88	FALSE
11	GTEx	Lung	RFTN2	0.06	0.08	lasso	8	0.06	2.7e-05	8.87	9.1	1.3e-19	0.91	0.10	0.90	FALSE
12	GTEx	Nerve Tibial	SF3B1	0.06	0.09	lasso	8	0.08	3.3e-06	8.85	8.7	2.6e-18	0.57	0.19	0.81	FALSE
13	GTEx	Pituitary	HSPD1	0.10	0.03	enet	12	0.06	1.3e-02	4.36	7.8	6.6e-15	0.48	0.08	0.37	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	SF3B1	0.08	0.00	enet	19	0.01	1.6e-01	8.87	6.7	1.5e-11	0.34	0.07	0.79	FALSE
15	GTEx	Skin Sun Exposed Lower leg	MARS2	0.04	0.05	enet	8	0.03	1.2e-03	8.55	-8.7	2.3e-18	-0.91	0.08	0.92	FALSE
16	GTEx	Spleen	RFTN2	0.11	0.03	enet	26	0.05	2.4e-02	8.47	9.4	3.8e-21	0.88	0.08	0.46	FALSE
17	GTEx	Spleen	MARS2	0.12	0.04	lasso	5	0.00	3.4e-01	8.59	-8.7	2.2e-18	-0.86	0.06	0.41	FALSE
18	GTEx	Stomach	SF3B1	0.11	0.00	enet	19	0.00	4.0e-01	8.12	5.4	6.4e-08	0.30	0.08	0.28	FALSE
19	GTEx	Testis	ANKRD44	0.33	0.35	enet	15	0.36	6.2e-17	7.53	7.6	2.8e-14	0.39	0.99	0.01	FALSE
20	GTEx	Testis	SF3B1	0.10	0.07	enet	17	0.08	2.6e-04	8.85	8.8	8.9e-19	0.57	0.08	0.91	FALSE
21	GTEx	Thyroid	SF3B1	0.04	0.02	enet	14	0.02	2.0e-02	8.28	9.4	4.3e-21	0.76	0.08	0.85	FALSE
22	GTEx	Thyroid	PLCL1	0.04	0.01	lasso	4	0.00	2.6e-01	8.26	9.3	1.7e-20	0.81	0.16	0.61	FALSE
23	GTEx	Thyroid	RFTN2	0.04	0.01	enet	11	0.01	9.5e-02	8.54	6.9	5.1e-12	0.84	0.14	0.58	FALSE
24	GTEx	Whole Blood	PLCL1	0.08	0.08	enet	15	0.05	4.1e-05	8.87	8.5	1.7e-17	0.97	0.02	0.98	FALSE
25	NTR	Blood	ANKRD44	0.03	0.00	bslmm	417	0.02	2.7e-06	8.24	-7.0	2.1e-12	-0.50	0.11	0.81	FALSE
26	NTR	Blood	PLCL1	0.02	0.01	enet	14	0.02	1.9e-06	8.87	6.4	2.0e-10	0.76	0.04	0.95	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	SF3B1	0.02	0.01	blup	336	0.01	6.2e-03	8.12	8.4	4.4e-17	0.52	0.13	0.80	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	RFTN2	0.03	0.04	blup	351	0.03	1.5e-04	8.07	-6.8	1.1e-11	-0.26	0.70	0.25	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	MARS2	0.05	0.03	enet	14	0.05	2.2e-07	-8.12	-7.1	1.0e-12	-0.79	0.15	0.85	FALSE
30	YFS	Blood	ANKRD44	0.02	0.00	blup	416	0.01	6.3e-04	1.65	-6.5	6.0e-11	-0.40	0.12	0.54	FALSE
31	YFS	Blood	PLCL1	0.10	0.10	lasso	9	0.14	1.5e-43	9.13	8.6	7.0e-18	0.88	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLCL1	0.04	0.00	blup	130	0.02	4.0e-03	-1.55	5.8	7.8e-09	0.64	0.05	0.37	FALSE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFTN2	0.05	0.01	blup	61	0.02	3.1e-02	8.87	9.6	9.3e-22	0.74	0.02	0.62	TRUE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLCL1	0.07	0.06	blup	130	0.07	1.8e-07	7.78	-6.0	2.2e-09	-0.25	0.98	0.01	FALSE