Best TWAS P=2.98e-09 · Best GWAS P=1.73e-08 conditioned to 0.171
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C6orf106 | 0.29 | 0.21 | bslmm | 382 | 0.23 | 6.9e-28 | -5.6 | -5.4 | 7.8e-08 | 0.84 | 0.01 | 0.99 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | PACSIN1 | 0.07 | 0.01 | lasso | 6 | 0.02 | 1.1e-03 | -5.5 | -5.9 | 3.0e-09 | 0.82 | 0.01 | 0.96 | TRUE |
3 | GTEx | Nerve Tibial | C6orf106 | 0.11 | 0.07 | enet | 17 | 0.07 | 1.3e-05 | -5.5 | -5.7 | 1.5e-08 | 0.89 | 0.01 | 0.99 | FALSE |
4 | GTEx | Thyroid | C6orf106 | 0.09 | 0.01 | enet | 29 | 0.01 | 1.1e-01 | -5.4 | -5.7 | 1.6e-08 | 0.75 | 0.01 | 0.84 | FALSE |
5 | METSIM | Adipose | C6orf106 | 0.04 | 0.02 | blup | 381 | 0.02 | 7.7e-04 | -4.3 | -5.5 | 3.5e-08 | 0.61 | 0.04 | 0.91 | FALSE |
6 | NTR | Blood | C6orf106 | 0.03 | 0.02 | lasso | 6 | 0.02 | 7.2e-07 | -5.4 | -5.8 | 7.5e-09 | 0.98 | 0.01 | 0.99 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | C6orf106 | 0.30 | 0.26 | bslmm | 372 | 0.33 | 9.3e-44 | -5.4 | -5.4 | 7.5e-08 | 0.85 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C6orf106 | 0.04 | 0.01 | blup | 68 | 0.01 | 2.4e-02 | -5.5 | -5.7 | 1.1e-08 | 0.88 | 0.01 | 0.74 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf106 | 0.04 | 0.05 | lasso | 4 | 0.03 | 8.1e-05 | -5.5 | -5.5 | 3.2e-08 | 0.98 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf106 | 0.14 | 0.07 | enet | 6 | 0.06 | 1.0e-04 | -5.4 | -5.9 | 4.0e-09 | 0.87 | 0.01 | 0.98 | FALSE |