Hub : Genes

C5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1600	0.0450	1.4e-09	0.087	0.088	0.085	0.092	0.096	1.0e-10	7.2e-11	1.6e-10	2.6e-11	1.1e-11
2	GTEx	Adipose Subcutaneous	0.1740	0.0460	3.6e-14	0.219	NA	0.197	NA	0.218	8.1e-18	NA	5.6e-16	NA	1.1e-17
3	GTEx	Artery Aorta	0.0640	0.0360	4.1e-03	0.016	NA	0.009	NA	0.019	4.1e-02	NA	1.0e-01	NA	2.9e-02
4	GTEx	Lung	0.1038	0.0446	1.5e-05	0.137	NA	0.101	NA	0.116	1.3e-10	NA	3.8e-08	NA	3.7e-09
5	GTEx	Nerve Tibial	0.1104	0.0457	8.3e-04	0.068	NA	0.039	NA	0.037	1.5e-05	NA	8.8e-04	NA	1.3e-03
6	GTEx	Testis	0.0860	0.0430	1.8e-03	0.057	NA	0.029	NA	0.038	1.6e-03	NA	1.9e-02	NA	8.6e-03
7	GTEx	Whole Blood	0.0370	0.0190	5.5e-03	0.011	NA	0.014	NA	0.015	2.8e-02	NA	1.6e-02	NA	1.5e-02
8	METSIM	Adipose	0.2434	0.0542	0.0e+00	0.258	0.218	0.256	0.257	0.256	2.2e-38	5.0e-32	5.0e-38	2.8e-38	4.3e-38
9	YFS	Blood	0.2421	0.0441	0.0e+00	0.273	0.272	0.290	0.284	0.288	9.6e-90	2.5e-89	2.7e-96	9.2e-94	2.1e-95
10	TCGA	Prostate Adenocarcinoma	0.0364	0.0205	4.5e-04	0.012	0.029	0.014	NA	0.019	1.6e-02	4.6e-04	1.1e-02	NA	3.5e-03
11	TCGA	Thyroid Carcinoma	0.1010	0.0490	1.1e-03	0.043	0.041	0.048	NA	0.041	4.8e-05	6.5e-05	1.6e-05	NA	7.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.7	1.0	2.2	1.0	1.3	-0.9	-0.3	0.8	1.3	0.4	1.5	1.4	1.2	0.2
Bipolar Disorder or Schizophrenia	2.0	5.0	7.5	2.7	2.5	-1.8	1.5	2.7	2.5	1.3	2.2	1.9	2.7	2.1
Depressed Affect (Nagel 2018)	0.6	1.3	3.7	1.2	0.8	-0.9	1.9	1.0	1.1	1.7	0.3	0.7	1.4	0.8
Depression (Nagel 2018)	2.6	3.9	6.1	1.7	1.9	-1.8	2.2	1.6	2.2	2.3	1.9	2.1	2.5	1.4
Intelligence (Savage-Jansen 2018)	0.1	0.5	3.2	-0.4	-0.2	-0.0	-0.5	-0.9	0.0	-0.0	0.1	0.5	-0.4	-1.8
Neuroticism (Nagel 2018)	0.9	2.1	5.0	1.4	1.1	-1.2	2.2	1.4	1.4	1.8	0.5	0.8	1.8	1.6
Schizophrenia (2018)	2.2	4.7	8.4	2.7	2.2	-1.6	2.1	2.9	2.2	1.3	1.6	1.3	2.5	2.6
Schizophrenia vs Biploar Disorder	0.8	1.1	9.1	0.1	-0.4	0.9	0.6	0.4	-0.1	-0.3	-0.9	-0.7	0.1	3.0
Worry (Nagel 2018)	0.4	0.9	3.9	1.0	0.6	-0.8	0.7	0.8	0.7	0.6	0.4	0.5	1.4	2.0
Alzheimer’s Disease (in mother)	0.7	0.9	3.8	0.6	0.9	-0.5	1.0	0.6	0.7	0.7	0.9	0.9	0.6	-2.0
Alzheimer’s Disease (in father)	2.0	2.2	3.9	1.3	1.7	-0.0	1.3	1.4	1.7	1.7	1.9	2.0	1.4	-0.6
Alzheimer’s Disease (including proxy)	1.7	2.5	5.1	1.1	1.7	0.2	1.5	1.0	1.6	1.6	1.9	2.3	1.2	-2.0
Crohns Disease (2017)	0.4	0.8	3.0	0.6	0.6	-1.7	1.2	0.4	0.9	1.1	0.7	0.9	0.5	-0.2
Irritable Bowel Disease (IBD)	0.1	0.4	1.8	-0.3	-0.2	-1.4	0.5	-0.6	0.1	0.8	0.2	0.4	-0.4	-0.7
Ulcerative Colitis (UC)	0.3	0.5	1.3	-0.9	-0.7	-0.8	-0.3	-1.2	-0.4	0.3	-0.2	-0.0	-0.9	-1.0
Major Depression (MDD)	0.1	0.2	0.7	0.3	0.3	-0.2	0.4	0.2	0.5	0.4	0.3	0.3	0.8	0.4
Reaction Time	2.8	5.4	11.4	-2.3	-2.5	3.4	-1.6	-2.3	-2.7	-2.5	-2.4	-2.0	-2.4	-0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.9	-0.2	-0.1	-0.6	-0.9	-0.6	0.1	-0.0	-0.0	0.3	-0.1	-0.1
Breast Cancer	3.2	7.6	17.1	2.2	2.4	-4.1	3.3	2.0	2.8	3.6	2.2	2.3	3.2	0.1
Ovarian Cancer	2.0	2.7	5.6	2.0	1.7	-2.4	0.8	1.9	1.5	0.9	1.5	1.1	2.1	1.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.4	2.7	0.5	0.4	1.7	-0.3	0.6	-0.2	-0.2	0.2	0.2	0.3	0.7
Bipolar Disorder (2011)	1.2	1.1	2.3	0.8	1.1	-1.4	-0.5	0.8	1.1	0.3	1.2	1.1	1.3	1.5
Body Mass Index (BMI) (2010)	2.0	2.8	4.5	-1.5	-2.0	0.4	-1.4	-1.7	-1.8	-2.0	-2.1	-2.0	-1.2	1.1
Coronary Artery Disease (CAD)	0.1	0.2	1.0	0.4	0.2	-0.1	-0.3	-0.0	0.4	-0.1	0.2	0.4	0.0	1.0
Crohns Disease (2012)	0.1	0.2	1.1	0.1	0.0	0.4	0.1	-0.0	0.0	0.1	0.1	0.1	-0.6	-1.1
Mean Putamen Volume	0.2	0.2	0.4	0.5	0.4	-0.5	0.5	0.4	0.5	0.6	0.4	0.4	0.6	-0.3
Fasting Glucose	2.6	3.1	5.7	1.6	1.6	-2.4	1.6	1.4	1.9	2.2	1.5	1.9	2.1	0.7
HbA1C	0.3	0.3	1.0	0.7	0.4	-0.5	-0.1	0.4	0.7	0.2	0.3	0.6	0.4	1.0
HDL Cholesterol	0.6	1.0	3.7	-1.0	-0.5	1.1	-1.9	-0.8	-1.0	-1.1	-0.1	-0.1	-1.0	-0.9
LDL Cholesterol	0.1	0.1	0.2	0.4	-0.1	-0.5	0.2	0.2	-0.3	-0.3	0.0	-0.4	-0.4	-0.2
Lupus	0.2	0.3	2.3	0.2	0.2	0.0	1.5	0.3	0.4	0.6	0.0	0.1	-0.0	-0.7
Neuroticism (2016)	0.7	1.1	1.8	0.8	1.2	-1.2	0.4	1.1	1.0	0.7	1.2	0.9	1.3	1.2
Primary Biliary Cirrhosis	0.5	0.7	1.8	0.7	0.9	1.3	-0.8	0.9	0.6	-0.7	1.0	0.6	0.5	1.0
Rheumatoid Arthritis	3.8	5.2	12.7	-1.6	-2.2	3.6	-0.7	-1.4	-2.5	-2.4	-2.3	-2.9	-2.9	-1.0
Schizophrenia (2014)	3.7	8.2	11.6	3.2	3.2	-2.4	1.8	3.3	3.3	2.1	2.9	2.7	3.4	2.8
Triglycerides	0.3	0.6	2.6	-0.0	-0.6	-0.6	1.6	-0.1	-0.4	-0.0	-1.1	-1.2	0.0	0.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	7.0	0.2	0.4	0.8	-2.6	0.0	0.2	-1.2	0.8	0.5	-0.1	0.9
Ulcerative Colitis	0.5	0.7	2.0	-1.4	-1.0	-0.5	-0.1	-1.3	-0.7	0.2	-0.6	-0.4	-1.0	-0.7
Blood Eosinophil Count	0.5	3.6	17.8	-0.9	-0.9	4.2	-0.9	-0.2	-1.8	-2.6	-1.2	-1.8	-1.9	-0.9
Blood Platelet Count	2.2	25.1	40.4	4.6	5.2	-4.7	3.6	4.4	5.7	5.3	5.0	5.9	6.4	3.5
Blood Red Count	1.3	12.2	16.6	-3.4	-3.7	4.1	-3.1	-3.5	-4.0	-3.7	-3.6	-3.5	-3.9	-0.6
Blood White Count	1.4	10.5	21.4	2.0	2.6	-3.0	2.5	1.9	3.5	4.1	2.2	3.8	4.6	3.9
Heel T-Score	0.5	3.6	6.7	-2.6	-2.3	2.4	-1.0	-2.3	-1.7	-1.1	-2.1	-1.0	-2.0	1.4
BMI	0.2	1.0	3.5	0.4	0.6	-0.0	1.1	0.0	1.3	1.9	0.3	1.4	1.1	0.5
Height	1.0	19.7	67.9	-4.7	-4.2	-2.2	-0.1	-4.4	-4.2	-2.7	-3.6	-4.7	-5.0	-8.2
Waist Hip Ratio (WHR)	1.0	4.7	7.5	-2.7	-2.7	-0.1	-1.1	-2.6	-2.4	-1.7	-2.7	-2.6	-2.4	-0.8
Systolic Blood Pressure	1.1	5.7	13.6	-1.7	-2.0	3.7	-3.2	-1.5	-2.3	-3.2	-1.8	-2.1	-2.4	0.4
Smoking Status	1.4	3.2	6.9	1.7	1.6	-2.0	2.6	1.5	2.0	2.5	1.4	1.4	1.8	-0.0
Allergy or Eczema	3.3	8.8	32.5	-1.1	-1.8	5.7	-3.0	-0.7	-2.7	-4.4	-1.7	-3.3	-3.0	0.9
Cardiovascular Disease	0.9	3.0	4.7	1.9	1.8	-1.1	1.1	1.8	2.1	1.5	1.6	1.6	2.2	1.9
Hypothyroidism (self reported)	4.6	10.5	17.4	-2.9	-3.1	4.2	-3.3	-3.0	-3.3	-3.7	-2.8	-3.0	-3.8	-2.1
Respiratory disease	2.2	4.8	18.3	-1.5	-1.7	4.3	-2.3	-1.3	-2.0	-3.2	-1.3	-1.7	-1.9	-0.5
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.5	0.4	-0.2	-1.9	1.4	0.3	0.1	0.2	-0.8	-0.7	0.8	1.7
Lung FEV1/FVC ratio	0.2	0.8	2.6	0.6	0.2	0.9	-1.6	0.8	-0.5	-1.6	0.4	-0.7	-0.6	-0.2
Lung FVC	0.3	1.4	4.9	-0.1	-0.6	0.6	-1.4	0.2	-1.0	-1.9	-0.9	-1.3	-0.3	2.2
Neuroticism	0.2	0.4	2.0	0.3	0.1	-0.3	1.0	0.3	0.5	0.8	-0.2	0.2	0.8	1.4
Chronotype (morning person)	0.6	1.4	2.2	-1.1	-1.3	1.4	-1.1	-1.2	-1.2	-0.9	-1.4	-1.2	-1.5	-0.0
Hair Pigment	0.5	13.4	29.9	-3.1	-3.4	5.5	-2.4	-2.8	-4.2	-4.0	-3.2	-3.7	-4.3	-2.5
Tanning	0.0	0.3	0.8	0.7	0.6	0.2	-0.9	0.4	0.6	-0.5	0.7	0.3	0.6	0.1
Hand grip strength (left)	1.6	4.3	9.5	-2.1	-1.9	0.3	-2.4	-2.3	-1.8	-2.1	-1.6	-1.5	-2.5	-3.1
Number of treatments/medications taken	0.2	0.3	1.1	0.2	0.2	-0.3	1.0	0.5	0.2	0.4	-0.0	-0.1	0.5	1.0
Average weekly spirits intake	0.2	0.3	1.3	0.0	0.4	-0.4	0.6	0.2	0.3	-0.1	0.7	0.4	0.6	-1.2
Sensitivity / hurt feelings	0.2	0.4	1.0	0.7	0.6	0.2	0.8	1.0	0.5	0.1	0.5	0.2	0.6	0.8
Frequency of depressed mood in last 2 weeks	2.6	3.6	5.8	2.0	2.1	-1.1	1.7	1.8	2.3	2.0	2.0	1.8	2.4	1.5
Hearing difficulty/problems: Yes	0.2	0.3	1.0	-0.2	-0.6	-0.1	0.2	-0.1	-0.8	-0.6	-0.9	-1.0	-0.4	0.4
Relative age of first facial hair	0.6	1.3	5.6	-0.4	-0.5	1.3	-0.2	-0.1	-1.2	-1.2	-0.5	-1.2	-1.4	-2.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.1	4.0	-1.1	-1.4	1.9	-1.0	-0.8	-1.9	-2.0	-1.6	-1.9	-1.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.5	0.6	0.4	-0.7	1.6	0.7	0.4	1.3	-0.0	0.4	1.0	1.0
Ever had hysterectomy (womb removed)	0.8	0.9	2.0	-0.7	-1.2	0.8	1.2	-0.6	-1.0	0.0	-1.4	-1.3	-1.0	-0.2
Systolic blood pressure, automated reading	1.7	4.8	10.6	-2.2	-2.2	2.6	-3.2	-2.1	-2.0	-2.3	-1.9	-1.7	-2.3	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.9	0.1	-0.0	-0.1	-0.3	0.1	-0.1	-0.7	-0.2	-0.2	0.5	0.9
Angina	1.0	1.3	6.3	-0.0	-0.4	2.1	-0.4	0.2	-0.5	-1.2	-0.6	-1.1	-0.1	2.5
Medication for hormone replacement therapy	0.7	0.8	1.6	-0.8	-1.1	-0.1	-0.7	-0.7	-1.2	-1.0	-1.3	-1.2	-0.7	0.4
Vitamin and mineral supplements	0.2	0.3	1.1	-0.1	-0.3	-1.1	0.5	-0.4	-0.2	1.0	-0.4	-0.0	-0.1	-0.5
Supplements: Zinc	0.2	0.2	0.5	-0.6	-0.3	0.4	0.4	-0.3	-0.4	-0.4	-0.5	-0.3	-0.1	-0.7
Medication: Co-codamol	1.7	1.9	3.2	0.8	1.2	-0.6	1.7	1.3	1.6	1.8	0.9	1.2	1.6	1.8
Medication: Metformin	2.2	3.1	5.1	1.9	1.4	-2.1	2.2	1.4	2.0	2.1	1.0	1.3	2.2	1.4
Diabetes (father)	3.5	4.3	6.1	-2.5	-2.4	1.8	-0.9	-2.3	-2.4	-1.8	-2.4	-2.2	-2.3	-1.1
Diabetes (mother)	0.7	0.9	3.0	-0.7	-0.6	-1.7	1.5	-0.8	0.1	1.4	-0.9	-0.1	0.3	0.8
Severe depression (siblings)	0.1	0.1	1.0	-0.3	-0.1	-1.0	-0.3	-0.2	-0.1	0.1	0.0	0.1	0.2	-0.2
Pack years adult smoking proportion	1.3	2.0	4.3	0.7	1.3	-0.8	1.2	0.7	2.0	1.9	1.3	2.1	1.8	1.0
Impedance of leg (right)	2.6	12.6	18.1	-3.8	-3.7	3.5	-2.2	-3.3	-4.3	-3.7	-3.6	-3.9	-4.1	-2.5
Leg fat-free mass (left)	0.5	2.6	7.4	0.6	1.0	-2.7	2.2	0.4	1.4	1.9	0.9	1.1	0.9	-2.5
Trunk fat percentage	0.3	1.3	3.0	-1.4	-1.1	1.7	0.7	-1.4	-0.6	0.1	-1.4	-0.7	-1.0	-1.5
Hand grip strength (right)	1.7	4.7	11.8	-2.4	-2.1	-0.1	-2.0	-2.5	-1.9	-2.0	-1.6	-1.4	-2.6	-3.4
Townsend deprivation index at recruitment	1.0	1.4	2.3	-1.4	-1.4	1.5	-0.7	-1.4	-1.1	-0.8	-1.1	-1.1	-1.5	-0.3
Current tobacco smoking	1.3	2.2	6.8	1.1	1.2	-1.0	2.6	1.0	1.4	2.2	1.2	1.2	1.1	-1.3
Average weekly fortified wine intake	1.2	1.4	2.4	-1.5	-1.2	0.7	-1.0	-1.1	-1.2	-1.4	-1.2	-1.2	-1.3	-0.5
Maternal smoking around birth	1.2	1.7	4.3	0.5	0.8	-2.0	1.7	0.6	1.5	2.1	0.5	1.2	1.2	1.0
Fed-up feelings	0.8	1.4	4.7	1.1	1.1	-0.4	2.2	1.2	1.3	1.6	0.9	0.6	1.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.9	3.9	7.3	1.6	1.9	-1.7	2.6	1.5	2.3	2.7	1.9	1.8	2.1	1.1
Relative age voice broke	0.5	0.8	1.6	0.8	0.8	-1.3	0.9	1.1	0.6	1.0	0.6	0.5	1.0	1.0
Taking other prescription medications	0.1	0.2	1.2	-0.2	-0.1	0.4	-1.1	-0.4	0.1	0.0	0.2	0.1	0.2	0.8
Age when periods started (menarche)	0.1	0.2	0.8	0.0	0.1	-0.3	0.7	0.3	0.1	0.3	0.2	0.1	0.4	0.9
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.2	-1.1	-1.4	1.4	-0.4	-1.0	-1.2	-0.6	-1.5	-1.0	-0.8	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.2	2.9	-1.7	-1.7	1.6	-1.3	-1.3	-1.4	-1.3	-1.6	-1.3	-1.7	1.0
Tinnitus: Yes, but not now, but have in the past	2.6	2.7	6.8	0.8	1.3	-2.4	1.6	0.6	2.2	2.6	1.4	1.7	1.7	0.2
Qualifications: CSEs or equivalent	0.7	1.0	7.3	0.7	0.2	2.7	0.4	1.0	-0.1	-0.5	0.2	-0.3	-0.1	1.2
Serious illness, injury or assault to yourself	1.4	1.6	4.2	-1.4	-1.2	2.0	-1.6	-1.4	-0.9	-1.5	-1.2	-0.8	-1.0	0.2
High blood pressure	0.7	1.9	3.1	1.5	1.3	-1.6	0.5	1.3	1.7	1.2	1.1	0.9	1.8	1.6
Hayfever, allergic rhinitis or eczema	4.9	10.6	40.9	-1.4	-2.1	6.4	-3.1	-1.0	-3.0	-4.7	-2.0	-3.4	-3.3	0.8
Multivitamins +/- minerals	0.3	0.4	1.8	-0.1	-0.1	0.9	-0.4	0.3	-0.2	-1.4	-0.1	-0.4	0.1	1.0
Stomach or abdominal pain in last month	0.2	0.2	0.6	-0.2	-0.2	-0.0	0.1	0.1	-0.8	-0.8	-0.5	-0.7	0.1	0.4
Supplements: Glucosamine	1.2	1.6	8.0	-0.9	-0.3	-1.9	1.5	-1.0	0.2	1.1	-0.1	0.3	-0.2	-2.8
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	2.2	-1.5	-1.4	1.3	-0.6	-1.3	-1.5	-1.2	-1.5	-1.1	-1.2	-1.2
Medication: Atenolol	1.2	1.4	3.3	1.5	1.6	-0.9	0.9	1.8	1.2	0.6	1.4	0.7	1.4	0.4
Medication: Levothyroxine sodium	1.9	3.2	6.4	-1.6	-1.7	2.5	-2.0	-1.4	-1.8	-2.2	-1.6	-1.8	-1.9	-0.6
Sitting height	0.5	3.7	19.0	-0.7	0.1	-4.0	1.9	-0.6	0.4	1.0	0.5	0.3	-0.0	-4.4
Chronic bronchitis/emphysema (father)	1.5	1.7	5.0	1.2	1.1	-2.2	0.9	0.7	1.4	1.5	1.1	1.5	1.4	-0.0
High blood pressure (mother)	0.3	0.5	1.3	-0.4	-0.6	0.7	1.2	-0.1	-0.7	0.2	-1.0	-1.0	-0.4	-0.3
Body mass index (BMI)	0.2	0.7	2.2	0.5	0.5	0.3	1.2	0.2	1.2	1.5	0.2	1.0	0.9	0.5
Impedance of leg (left)	2.3	11.2	15.0	-3.5	-3.5	3.8	-2.3	-3.2	-3.9	-3.5	-3.2	-3.4	-3.8	-2.3
Leg predicted mass (left)	0.5	2.6	7.5	0.5	0.9	-2.7	2.2	0.4	1.3	1.9	0.9	1.1	0.9	-2.6
Trunk fat mass	0.4	1.8	6.0	-1.7	-1.4	0.8	0.9	-1.7	-0.8	0.1	-1.5	-0.9	-1.2	-2.4
Waist circumference	0.3	1.3	3.2	-1.5	-1.4	0.5	0.0	-1.8	-0.7	-0.2	-1.4	-0.7	-1.0	-1.5
Number of incorrect matches in round	0.4	0.6	2.5	-0.4	-0.2	1.5	-1.6	-0.3	-0.3	-1.1	0.0	-0.1	-0.4	0.6
Past tobacco smoking	1.0	1.9	2.5	-1.1	-1.3	1.5	-1.5	-1.0	-1.3	-1.6	-1.5	-1.5	-1.5	1.2
Alcohol usually taken with meals	1.8	3.0	5.9	-1.4	-1.5	1.6	-1.9	-1.4	-1.6	-2.4	-1.4	-1.7	-2.0	-1.8
Nervous feelings	0.2	0.4	1.7	-0.6	-0.7	0.1	-0.4	-0.5	-0.6	-0.4	-0.8	-0.8	-0.2	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	2.1	0.3	0.2	0.0	1.4	0.3	0.4	0.9	-0.1	-0.0	0.9	0.8
Hearing difficulty/problems with background noise	0.2	0.4	1.4	-0.0	-0.3	-1.2	0.4	0.2	-0.3	0.1	-0.8	-0.9	0.3	0.8
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	-0.7	-0.4	0.0	-0.6	-0.6	-0.2	-0.2	-0.4	0.1	-0.2	0.3
Had menopause	0.2	0.2	0.6	-0.2	-0.5	-0.6	0.8	-0.2	-0.3	0.4	-0.6	-0.4	0.1	0.6
Had other major operations	0.3	0.4	1.0	-0.6	-0.4	1.0	-0.4	-0.4	-0.7	-0.6	-0.4	-0.1	-0.6	-1.0
Forced vital capacity (FVC)	0.5	2.1	3.6	-1.4	-1.3	0.4	-0.7	-1.0	-1.7	-1.6	-1.3	-1.8	-1.8	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.9	-1.3	-1.2	1.4	-1.0	-0.9	-0.9	-0.9	-1.0	-0.5	-1.1	1.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.6	0.5	0.1	0.0	1.3	0.6	0.0	0.0	-0.1	-0.6	0.2	0.2
Qualifications: None of the above	0.3	0.5	1.7	-0.4	-0.1	-0.9	0.9	-0.5	0.5	1.3	-0.1	0.6	0.6	1.1
Financial difficulties in last 2 years	0.8	1.1	2.4	-1.2	-1.3	1.6	0.2	-1.1	-1.0	-0.5	-1.4	-1.1	-0.8	0.2
Mouth/teeth dental problems	1.8	2.7	4.5	-2.1	-1.7	0.4	-1.7	-2.0	-1.7	-1.1	-1.5	-1.3	-2.0	-1.9
Heart attack	0.1	0.1	0.4	-0.5	-0.0	0.3	-0.4	-0.4	0.2	-0.0	0.3	0.6	0.3	0.3
Allergy	3.1	7.2	33.2	0.8	1.7	-5.8	1.9	0.4	2.4	3.8	1.8	2.8	2.3	-1.3
Pain all over the body in last month	3.1	3.3	6.7	-1.9	-2.0	2.6	1.1	-1.8	-1.8	-1.1	-2.4	-1.9	-1.7	-1.1
Diabetes (self-reported)	0.6	1.0	2.9	1.2	0.6	-1.7	1.3	0.9	0.8	0.7	0.1	0.1	1.2	1.0
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	10.8	-0.9	-1.0	3.3	-1.0	-0.6	-1.3	-1.8	-1.0	-1.6	-1.4	0.2
Medication: Ramipril	0.5	0.7	4.4	-0.4	-0.4	-1.0	-0.7	-0.7	0.2	0.3	-0.4	0.2	0.4	2.1
Medication: Simvastatin	0.1	0.1	0.9	0.4	0.1	-0.2	-0.3	0.4	0.2	0.1	0.0	-0.2	0.2	1.0
Fluid intelligence score	0.1	0.2	1.3	0.0	0.0	-1.1	-0.0	-0.1	0.1	0.1	0.0	0.1	0.2	0.7
Illnesses of siblings	0.5	0.7	4.3	-0.7	-0.5	0.3	-0.5	-0.7	-0.5	-0.3	-0.1	-0.4	-1.2	-2.1
Neuroticism score	0.6	1.2	2.1	1.2	1.1	-0.2	1.3	1.4	1.2	0.9	0.8	0.5	1.4	1.5
Weight	0.3	1.3	7.4	-1.1	-0.7	-0.6	1.2	-1.2	-0.1	0.6	-0.8	-0.2	-0.6	-2.7
Impedance of arm (right)	0.6	3.0	5.1	-1.8	-1.7	2.3	-0.8	-1.5	-1.7	-1.8	-1.5	-1.9	-2.0	-1.6
Arm fat percentage (right)	0.1	0.5	1.8	-0.4	-0.3	1.4	1.1	-0.6	0.4	0.9	-0.6	0.2	0.1	-0.3
Trunk fat-free mass	0.5	2.7	16.3	-0.9	-0.3	-3.1	1.1	-1.0	-0.1	0.8	-0.1	0.0	-0.5	-4.0
Hip circumference	0.2	0.7	5.2	-0.7	-0.3	0.9	0.1	-0.9	0.2	0.1	-0.1	0.5	-0.3	-2.3
Time employed in main current job	0.6	0.7	1.6	-1.1	-1.1	-0.9	-0.9	-1.3	-0.8	-0.1	-0.9	-0.5	-0.8	-0.0
Alcohol intake versus 10 years previously	2.3	3.4	5.0	1.8	1.8	-1.8	1.9	1.4	2.2	2.1	2.0	2.1	1.8	0.8
Father’s age at death	0.7	1.0	1.6	-1.3	-1.0	0.2	-0.7	-0.8	-1.0	-0.9	-1.0	-1.2	-0.9	-1.2
Worrier / anxious feelings	0.6	1.1	3.4	1.0	0.9	-1.2	0.5	1.2	1.0	0.6	0.7	0.2	1.3	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	-0.3	-0.4	-0.8	1.2	-0.3	0.0	0.9	-0.9	-0.4	0.4	1.0
Falls in the last year	0.5	0.6	1.6	0.8	0.8	0.0	0.4	0.5	1.0	1.0	0.8	1.3	0.8	0.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	0.7	0.7	0.1	1.1	1.0	0.5	0.5	0.6	0.4	0.6	-0.4
Number of live births	0.5	0.7	2.1	-1.3	-0.9	-0.1	-0.4	-1.4	-0.8	0.2	-0.6	0.1	-0.7	-1.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	5.1	-1.3	-1.4	1.2	-1.3	-0.9	-1.9	-2.3	-1.4	-2.1	-2.0	-1.2
Pulse rate	1.2	2.0	5.5	1.3	1.2	-2.3	1.0	1.0	1.2	1.6	1.0	1.3	1.6	1.6
Happiness	2.7	3.3	7.7	1.4	1.8	-1.7	1.9	1.3	2.1	2.8	1.9	1.9	1.9	0.5
Noisy workplace	1.0	1.2	2.3	-1.2	-1.3	1.0	-1.2	-1.5	-0.8	-0.9	-1.2	-0.6	-1.4	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.6	0.1	0.1	-1.1	0.7	0.2	0.1	-0.3	-0.4	-0.6	0.3	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	3.1	0.3	0.1	-1.8	0.8	-0.0	0.5	0.9	-0.0	0.5	0.9	0.2
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.6	0.7	-0.3	-0.0	0.5	0.5	0.4	0.7	0.9	1.0	0.2
Asthma	0.8	1.5	11.0	0.2	-0.3	3.3	-0.1	0.5	-0.6	-1.6	-0.5	-0.9	-0.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	3.1	1.7	1.6	-1.2	1.0	1.7	1.5	1.1	1.7	1.3	1.8	1.2
Medication: Cholesterol lowering	0.4	0.7	2.5	1.1	0.8	-0.2	-0.3	1.0	0.7	0.4	0.9	0.5	0.6	1.6
Depression (self-reported)	0.3	0.4	1.2	1.1	0.4	0.3	0.3	1.1	0.2	-0.5	0.1	-0.5	0.4	0.9
Medication: Lansoprazole	0.7	0.7	4.4	0.2	-0.1	2.1	-0.5	0.4	-0.3	-0.7	-0.1	-0.6	-0.2	1.5
Prospective memory result	1.6	1.9	3.2	-1.6	-1.5	1.4	-1.8	-1.6	-1.3	-1.5	-1.2	-1.1	-1.5	0.1
Lung cancer (father)	2.2	2.5	4.9	1.3	1.2	-2.1	1.1	0.8	1.7	2.2	0.8	1.8	2.2	1.3
Illnesses of mother	0.2	0.3	0.9	0.8	0.2	-0.3	1.0	0.8	-0.0	-0.2	-0.2	-0.5	0.1	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	9.7	-1.3	-1.8	1.3	-1.3	-0.9	-2.4	-3.1	-2.0	-2.9	-2.3	-1.3
Pulse wave Arterial Stiffness index	2.5	2.9	6.7	1.6	1.4	-2.6	1.9	1.5	1.5	1.9	1.3	1.4	1.7	1.8
Impedance of arm (left)	0.6	2.9	5.2	-1.7	-1.6	2.3	-0.9	-1.4	-1.8	-1.8	-1.5	-1.8	-2.1	-1.5
Arm fat mass (right)	0.2	0.6	2.6	-0.7	-0.4	0.4	1.2	-0.9	0.2	1.0	-0.6	0.2	-0.2	-1.6
Trunk predicted mass	0.5	2.7	16.2	-0.9	-0.4	-3.0	1.1	-1.1	-0.1	0.8	-0.1	0.0	-0.6	-4.0
Standing height	1.0	10.2	48.2	-3.3	-2.6	-2.2	0.1	-3.0	-2.6	-1.6	-2.0	-2.6	-3.4	-6.9
Length of working week for main job	0.2	0.3	0.9	-0.3	0.2	0.3	-0.9	-0.2	-0.0	0.2	0.6	0.8	-0.0	-1.0
Exposure to tobacco smoke at home	0.8	0.9	1.5	1.0	1.0	0.7	0.2	0.9	1.2	0.8	1.2	1.0	1.2	0.9
Breastfed as a baby	0.9	1.1	5.5	-0.7	-0.5	1.6	-2.4	-0.7	-0.6	-1.2	-0.1	-0.3	-0.9	-0.5
Tense / ‘highly strung’	0.1	0.1	0.3	-0.5	-0.3	-0.4	-0.6	-0.6	-0.2	0.1	-0.2	-0.2	-0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.4	-0.3	-0.6	-0.5	1.6	-0.4	-0.0	1.0	-1.0	-0.4	0.4	1.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	-0.5	-0.7	-0.3	-0.4	-0.4	-0.8	-0.9	-0.9	-1.2	-0.6	-0.1
Birth weight of first child	1.4	2.5	5.9	1.2	1.2	-2.4	1.8	1.1	1.6	1.9	1.0	1.4	1.7	1.3
Peak expiratory flow (PEF)	0.7	1.6	5.9	-0.8	-0.8	1.6	-0.4	-0.7	-1.2	-1.6	-0.8	-1.0	-1.3	-2.4
Pulse wave reflection index	0.3	0.4	0.8	-0.9	-0.8	-0.2	0.1	-0.6	-0.6	-0.4	-0.6	-0.8	-0.9	-0.6
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.7	0.8	1.1	-0.7	0.6	1.0	1.4	1.2	1.0	1.1	1.6	1.9
Loud music exposure frequency	0.3	0.4	1.6	0.6	0.5	-0.2	0.4	0.6	0.6	0.3	0.3	0.6	0.5	1.3
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	4.0	1.2	0.9	-0.2	2.0	1.2	0.7	0.9	0.2	0.1	0.6	-0.5
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	3.6	1.9	1.7	-0.9	1.2	1.6	1.9	1.5	1.6	1.4	1.6	1.0
Blood clot in the leg (DVT)	0.4	0.5	1.6	-0.0	-0.4	0.8	-0.8	0.2	-0.6	-1.3	-0.4	-0.9	-0.5	1.0
Medication: Paracetamol	0.8	1.4	4.6	0.9	1.1	-0.5	2.1	1.5	0.9	1.2	0.9	0.8	1.3	0.8
Headache pain in last month	0.8	1.3	3.9	1.6	1.5	-0.1	0.2	2.0	0.9	0.0	1.4	0.5	1.3	1.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	1.0	-0.8	-0.3	0.2	0.2	-0.7	-0.1	0.2	-0.2	0.2	-0.2	-1.0
Glaucoma (self-reported)	0.8	1.0	5.7	1.0	0.6	-0.8	2.4	0.8	0.6	1.0	0.1	0.2	0.7	-0.7
Gout (self-reported)	2.6	3.5	6.3	2.5	2.0	-1.8	1.1	2.2	2.1	1.6	1.8	1.4	1.8	1.9
Hypothyroidism/myxoedema (self-reported)	3.4	6.6	8.8	-2.5	-2.5	3.0	-2.8	-2.5	-2.6	-3.0	-2.3	-2.4	-2.9	-1.5
Medication: Amlodipine	0.5	0.8	1.3	-1.0	-1.0	-0.1	-1.2	-0.9	-0.8	-0.9	-0.8	-1.1	-0.9	0.0
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.9	0.2	-0.5	2.2	-1.0	0.4	-0.8	-1.7	-0.6	-1.3	-0.4	1.8
Birth weight	2.2	4.8	11.0	1.7	1.9	-3.3	2.3	1.4	2.2	3.0	1.6	2.3	2.5	0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	-1.2	-1.0	-0.4	0.6	-1.1	-0.9	-0.3	-1.1	-0.5	-0.3	-0.5
High blood pressure (siblings)	0.3	0.4	1.3	0.5	0.3	-0.6	1.1	0.5	0.3	0.5	-0.2	0.0	0.8	1.1
Forced vital capacity (FVC), Best measure	0.9	3.4	7.2	-1.5	-1.7	0.7	-1.0	-1.1	-2.2	-2.7	-1.8	-2.6	-2.1	-1.8
Body fat percentage	0.3	1.1	3.0	-1.3	-1.1	1.7	0.6	-1.3	-0.6	0.1	-1.3	-0.7	-0.8	-1.1
Leg fat percentage (right)	0.5	1.7	4.2	-1.5	-1.4	2.0	-0.0	-1.6	-1.1	-0.4	-1.6	-1.0	-1.1	-1.1
Arm fat-free mass (right)	0.3	1.6	7.9	-0.5	-0.2	-2.4	1.3	-0.6	0.1	1.0	-0.1	0.1	-0.2	-2.8
Exposure to tobacco smoke outside home	0.4	0.6	1.7	0.0	-0.4	0.8	-0.9	-0.0	-0.6	-1.2	-0.5	-0.8	-0.1	1.3
Comparative body size at age 10	0.1	0.3	0.7	0.6	0.6	0.1	-0.5	0.2	0.6	0.2	0.6	0.9	0.5	-0.1
Number of full brothers	0.1	0.2	0.7	-0.2	0.0	-0.8	0.5	-0.1	0.1	0.5	-0.1	-0.0	0.6	0.6
Worry too long after embarrassment	0.2	0.4	1.7	0.2	0.1	0.7	0.8	0.8	-0.2	-0.4	-0.2	-0.4	0.3	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.9	-0.5	-1.0	0.8	0.3	-0.3	-1.0	-0.9	-1.5	-1.5	-0.1	1.7
Wheeze or whistling in the chest in last year	0.2	0.4	2.9	-0.1	-0.3	1.7	0.3	0.2	-0.3	-0.6	-0.6	-0.8	-0.1	0.4
Number of children fathered	0.1	0.1	0.5	0.6	0.5	-0.4	0.4	0.7	0.1	0.3	0.2	-0.3	-0.0	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.1	-0.2	-0.4	0.9	-0.6	0.3	-0.7	-1.4	-0.8	-1.4	-0.5	1.0
Age at first live birth	1.4	2.4	5.5	-1.3	-1.2	1.3	-2.2	-1.6	-1.3	-1.8	-0.8	-0.8	-1.7	-2.3
Pulse wave peak to peak time	2.8	3.3	5.4	-1.8	-1.5	2.3	-1.9	-1.7	-1.7	-2.1	-1.4	-1.6	-1.9	-1.9
Health satisfaction	2.3	3.0	5.6	1.5	1.8	-0.9	1.4	1.5	2.0	1.9	1.8	1.9	2.4	1.8
Shortness of breath walking on level ground	1.3	1.5	3.4	0.6	0.8	-1.2	1.4	0.3	1.0	1.8	0.8	1.6	1.8	1.0
Qualifications: College or University degree	0.8	2.5	18.2	-1.2	-0.9	0.2	-0.6	-1.1	-1.1	-1.2	-0.3	-0.7	-1.4	-4.3
Eye problems/disorders: None of the above	0.3	0.4	2.0	0.2	0.2	0.5	-1.4	0.2	-0.1	-0.9	0.6	0.2	0.0	0.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.0	-1.1	-1.3	0.9	-0.3	-0.9	-1.5	-1.7	-1.4	-1.6	-0.8	0.0
Emphysema/chronic bronchitis	0.6	0.6	1.6	-0.7	-0.8	0.7	-1.3	-0.8	-0.8	-1.0	-0.5	-0.5	-0.3	1.0
Medication for pain relief, constipation, heartburn	2.9	5.0	8.4	-2.5	-2.2	1.5	-2.3	-2.9	-2.0	-1.8	-1.8	-1.3	-2.7	-2.9
Neck or shoulder pain in last month	0.6	0.8	2.5	-0.9	-0.9	0.5	-1.6	-0.8	-0.9	-1.2	-0.9	-0.6	-0.2	0.8
Medication: Blood pressure	0.7	1.2	2.5	1.6	1.2	-0.9	0.6	1.5	1.1	0.6	0.9	0.4	1.2	1.5
Angina (self-reported)	0.8	1.1	4.7	0.0	-0.4	1.9	-0.4	0.2	-0.5	-1.1	-0.6	-1.0	-0.1	2.2
Migraine (self-reported)	1.3	1.6	4.1	1.1	1.2	-2.0	1.0	1.5	1.1	1.2	0.8	0.5	1.6	0.9
Medication: Ibuprofen	1.9	2.3	4.1	1.6	1.7	-1.1	0.6	1.6	1.7	1.4	2.0	1.7	1.8	0.8
Medication: Allopurinol	1.6	2.2	3.6	1.8	1.7	-1.5	0.6	1.5	1.9	1.6	1.5	1.6	1.4	0.8
Medication: Omeprazole	0.8	1.0	3.7	0.5	0.7	-1.4	0.8	0.1	0.9	1.9	0.6	1.1	1.0	-0.5
Medication: Seretide 50 evohaler	2.3	2.7	4.2	1.9	2.0	-0.4	0.6	1.9	1.9	1.2	2.0	1.5	2.0	1.5
Mean time to correctly identify matches	2.1	4.1	5.7	-2.3	-2.4	2.3	-1.6	-2.3	-2.3	-1.8	-2.4	-1.7	-2.0	0.1
Heart disease (mother)	0.5	0.6	3.2	-0.0	0.0	-0.5	-1.6	-0.3	0.4	0.1	0.2	0.6	0.4	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	3.5	0.3	0.3	-0.2	1.9	0.5	0.3	0.6	0.1	0.2	0.7	-0.6
Whole body fat mass	0.3	1.1	4.1	-1.3	-1.0	0.6	0.8	-1.4	-0.4	0.4	-1.1	-0.4	-0.8	-2.0
Leg fat mass (right)	0.3	1.2	4.1	-1.4	-1.1	0.7	0.7	-1.5	-0.6	0.2	-1.3	-0.6	-0.8	-2.0
Arm predicted mass (right)	0.3	1.5	7.1	-0.3	0.0	-2.5	1.3	-0.4	0.2	1.0	0.1	0.2	-0.1	-2.7
Pulse rate, automated reading	3.0	9.7	19.5	2.9	2.8	-4.4	2.7	2.6	3.1	3.2	2.6	2.9	3.7	2.8
Alcohol intake frequency.	0.2	0.4	2.1	0.8	0.3	-0.3	0.1	0.6	0.3	0.0	0.1	0.0	1.0	1.4
Comparative height size at age 10	0.8	4.6	15.6	-2.4	-1.9	-2.7	-0.5	-2.2	-1.7	-1.0	-1.7	-1.8	-1.9	-4.0
Number of full sisters	1.0	1.2	3.3	-1.1	-1.1	1.8	0.6	-0.9	-1.2	-0.7	-1.1	-1.1	-1.1	-0.8
Suffer from ‘nerves’	2.0	3.2	6.0	2.1	1.8	-1.7	1.3	1.8	2.0	1.5	1.7	1.5	2.4	1.6
Overall health rating	0.3	0.7	3.0	0.5	0.4	-0.1	0.9	0.5	0.7	1.1	0.1	0.3	1.2	1.7
Chest pain or discomfort	0.4	0.6	1.3	-0.6	-0.9	1.0	-0.3	-0.7	-0.8	-0.6	-1.1	-1.0	-0.6	0.4
Had major operations	0.4	0.5	4.0	0.0	-0.1	2.0	-0.6	0.2	-0.4	-0.8	-0.2	-0.6	-0.5	-0.1
Age at last live birth	1.0	1.4	3.8	-1.4	-1.1	0.5	-1.3	-1.4	-1.2	-1.3	-0.8	-0.6	-1.0	-1.9
Family relationship satisfaction	5.1	6.3	11.6	1.9	2.4	-2.0	1.9	1.6	2.9	3.4	2.8	3.2	2.8	2.1
Leg pain on walking	1.2	1.5	2.6	1.4	0.9	-1.6	1.6	1.3	0.8	1.2	0.5	0.2	1.6	1.4
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	4.4	-1.1	-1.6	2.1	-1.9	-1.2	-1.8	-1.8	-1.7	-1.9	-2.1	-0.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.7	0.7	1.0	-0.6	1.2	0.7	1.3	1.3	0.8	1.2	0.9	-0.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.9	1.5	1.5	-0.5	-0.1	1.4	1.0	0.4	1.7	1.1	0.6	-0.3
Medication: Aspirin	1.1	1.5	3.6	1.3	1.1	-0.8	1.2	1.4	1.2	1.0	0.9	0.6	1.3	1.9
Supplements: Vitamin C	1.8	2.1	3.6	0.9	1.4	-1.7	0.9	0.8	1.7	1.7	1.6	1.9	1.4	-1.7
Knee pain experienced in last month	0.5	0.7	1.5	0.7	0.8	-0.4	-0.8	0.6	0.8	0.1	1.1	1.1	1.0	1.2
Hypertension (Self-reported)	0.5	1.4	2.5	1.3	1.0	-1.6	0.7	1.0	1.4	1.2	0.8	0.6	1.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.2	6.1	9.4	2.6	3.0	-1.7	0.8	2.7	2.9	2.4	3.1	2.7	2.7	1.3
Illnesses of father: Heart disease	0.6	0.8	3.5	0.1	0.1	1.4	-1.8	0.3	-0.2	-0.6	0.1	0.1	-0.1	1.9
Illnesses of siblings: Diabetes	0.8	1.0	2.4	-0.7	-1.3	0.2	0.6	-0.8	-1.2	-0.8	-1.5	-1.3	-0.4	1.3
Smoking status: Previous	0.9	1.3	2.4	1.1	1.3	-1.4	0.2	0.8	1.2	0.9	1.5	1.6	1.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	6.2	-0.9	-0.6	0.2	0.2	-0.7	-0.5	-0.7	-0.4	-1.0	-1.3	-2.5
Whole body fat-free mass	0.4	2.3	11.3	-0.3	0.2	-3.1	1.6	-0.5	0.5	1.3	0.3	0.5	0.1	-3.4
Leg fat-free mass (right)	0.5	2.6	7.3	0.8	1.1	-2.7	2.0	0.5	1.6	1.9	1.1	1.4	1.0	-2.2
Arm fat percentage (left)	0.1	0.4	2.2	-0.4	-0.3	1.5	0.9	-0.6	0.2	0.7	-0.6	0.1	-0.0	-0.3
Average weekly red wine intake	0.3	0.4	1.6	0.4	0.2	0.8	0.5	0.7	-0.1	-0.9	0.1	-0.6	-0.2	-1.3
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.1	-0.7	-0.7	1.1	-1.5	-0.7	-1.0	-1.1	-0.6	-0.8	-1.1	-0.2
Mood swings	0.7	1.3	2.1	1.3	1.1	-0.6	0.8	1.0	1.4	1.4	0.9	1.0	1.5	1.2
Loneliness, isolation	1.2	1.7	3.7	1.0	1.2	-0.6	1.2	0.9	1.6	1.9	1.4	1.6	1.6	0.4
Long-standing illness, disability or infirmity	0.6	0.9	4.2	0.3	0.0	1.6	-1.1	0.3	0.0	-1.1	-0.1	-0.2	0.2	2.0
Ever had bowel cancer screening	0.8	0.9	3.2	0.6	0.6	-1.8	-0.1	0.7	0.9	1.0	0.3	0.3	1.0	1.7
Diabetes diagnosed by doctor	0.4	0.6	2.5	0.6	0.1	-1.6	0.5	0.3	0.3	0.1	-0.3	-0.3	0.9	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.7	1.5	1.5	0.4	0.6	1.6	1.5	0.9	1.3	1.4	1.7	1.3
Friendships satisfaction	2.4	3.0	5.5	1.4	1.6	-1.2	0.6	1.1	2.0	2.1	1.8	2.0	1.8	2.3
Qualifications: nursing, teaching	1.4	2.2	3.6	-1.9	-1.8	-0.1	-0.5	-1.9	-1.4	-1.1	-1.8	-1.5	-1.6	-1.6
Commuting to job workplace: Walk	0.4	0.4	0.5	-0.6	-0.7	0.7	0.7	-0.6	-0.7	-0.6	-0.7	-0.6	-0.4	-0.5
Eye problems/disorders: Cataract	0.6	0.7	2.7	0.3	0.4	-1.3	0.9	0.0	0.6	1.3	0.4	0.7	0.2	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	2.3	0.5	0.3	0.6	0.2	0.5	0.4	-0.0	0.3	0.2	0.6	1.5
Medication for cholesterol	0.1	0.2	0.9	0.2	0.4	0.9	0.1	0.3	0.1	0.1	0.6	0.4	-0.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.9	-0.6	-0.5	1.3	-1.1	-0.5	-0.5	-1.4	-0.4	-0.5	-0.9	-0.7
Back pain experienced in last month	0.4	0.5	1.5	0.7	0.7	-0.0	-0.4	0.4	0.8	0.6	0.8	0.9	0.8	1.2
Mineral and other dietary supplements	0.1	0.1	0.7	0.5	0.2	0.1	0.3	0.3	0.3	0.5	-0.1	-0.0	0.2	0.9
Breast cancer (self-reported)	2.6	3.1	7.2	-2.0	-1.8	2.2	-2.7	-2.2	-1.5	-1.8	-1.4	-0.7	-1.4	-0.6
Asthma (self-reported)	1.0	1.9	13.8	0.0	-0.5	3.7	-0.3	0.3	-0.8	-1.9	-0.6	-1.1	-0.5	0.8
Osteoporosis (self-reported)	0.4	0.4	1.2	0.8	0.8	-0.7	0.7	1.1	0.4	0.4	0.6	0.3	0.6	0.5
Osteoarthritis (self-reported)	3.0	3.9	6.1	1.5	1.6	-2.4	2.2	1.4	2.2	2.4	1.4	1.9	2.5	1.9
Medication: Aspirin	1.6	2.1	4.5	1.8	1.5	-0.6	1.0	1.7	1.5	1.0	1.3	1.0	1.7	2.1
Medication: Gliclazide	1.5	1.7	4.9	1.4	0.9	-2.2	0.7	0.7	1.4	1.3	0.6	1.0	1.4	1.6
Illnesses of father: None of the above (group 1)	1.0	1.2	2.2	0.9	1.2	-1.3	0.7	0.7	1.3	1.1	1.5	1.4	1.1	-0.1
Smoking status: Current	1.3	2.1	8.2	1.1	1.1	-0.8	2.9	1.1	1.3	2.0	1.0	0.9	1.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	7.2	-2.3	-2.3	1.8	-1.6	-1.9	-2.6	-2.7	-2.5	-2.3	-2.0	0.3
Whole body water mass	0.4	2.3	12.0	-0.3	0.2	-2.9	1.6	-0.5	0.5	1.3	0.3	0.5	0.0	-3.5
Leg predicted mass (right)	0.5	2.7	7.5	0.7	1.1	-2.7	2.1	0.5	1.6	2.0	1.1	1.4	1.0	-2.3
Arm fat mass (left)	0.1	0.5	1.6	-0.7	-0.5	0.5	1.0	-0.8	0.1	0.7	-0.7	0.0	-0.2	-1.3
Number of self-reported non-cancer illnesses	0.9	1.5	4.3	1.6	1.3	0.6	0.4	1.7	1.1	0.4	1.1	0.5	1.3	2.1
Average weekly champagne plus white wine intake	0.6	0.8	2.8	-0.9	-1.0	-0.2	0.0	-1.1	-0.7	-0.3	-1.0	-0.7	-1.0	-1.7
Miserableness	2.6	4.5	8.3	2.4	2.2	-1.5	2.9	2.4	2.3	2.5	1.8	1.6	2.4	0.6
Guilty feelings	1.3	2.0	3.7	1.7	1.8	0.3	1.8	1.9	1.6	1.2	1.5	1.0	1.2	-0.3
Wears glasses or contact lenses	0.6	0.7	2.6	-1.1	-0.8	0.2	-1.6	-1.3	-0.6	-0.1	-0.5	0.1	-0.5	-0.5
Ever taken oral contraceptive pill	1.7	1.9	2.9	1.5	1.6	-1.2	1.2	1.6	1.6	1.7	1.6	1.3	1.1	-0.0
Hearing aid user	1.4	1.6	2.1	-1.2	-1.4	0.9	-1.3	-1.1	-1.3	-1.3	-1.5	-1.5	-1.3	0.7
Mother’s age at death	1.9	2.4	3.6	1.8	1.8	-1.7	0.4	1.6	1.9	1.5	1.9	1.7	1.3	0.5
Financial situation satisfaction	0.1	0.1	0.4	-0.6	-0.4	-0.0	-0.5	-0.6	-0.1	0.0	-0.2	-0.2	-0.2	0.7
Tinnitus: Yes, now most or all of the time	0.9	1.0	3.4	-0.7	-0.9	0.6	-1.8	-0.9	-1.1	-1.2	-0.9	-0.8	-1.1	0.0
Commuting to job workplace: Public transport	0.3	0.4	0.7	-0.4	-0.7	0.6	0.4	-0.4	-0.8	-0.6	-0.8	-0.9	-0.7	-0.0
Eye problems/disorders: Glaucoma	0.3	0.4	2.7	0.4	0.1	-0.0	1.6	0.4	0.0	0.3	-0.4	-0.5	-0.0	-0.9
Medication: Blood pressure	1.0	1.8	3.5	1.4	1.4	-1.5	0.9	1.3	1.6	1.5	1.3	1.2	1.9	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.2	0.0	0.1	-1.1	0.0	-0.2	0.4	0.5	0.1	0.7	0.6	0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.8	-0.5	0.1	0.3	-1.3	-0.3	-0.1	-0.5	0.4	0.5	0.2	0.2
High cholesterol (Self-reported)	3.1	5.5	8.9	3.0	2.8	-1.8	0.7	2.8	2.5	1.5	2.7	2.2	2.7	2.0
Medication: Bendroflumethiazide	3.4	5.2	8.1	2.6	2.6	-1.5	1.1	2.6	2.6	2.0	2.5	2.4	2.8	1.5
Medication: Paracetamol	0.6	0.9	4.7	0.4	0.8	0.1	2.2	1.0	0.5	0.9	0.7	0.7	1.0	0.0
Medication: Lisinopril	0.6	0.8	1.6	1.2	1.1	-0.4	0.2	1.1	1.0	0.7	0.9	0.7	1.2	0.4
Medication: Atorvastatin	0.4	0.5	0.8	0.9	0.8	-0.7	0.1	0.5	0.7	0.8	0.8	0.9	0.9	0.7
Illnesses of father: High blood pressure	0.2	0.3	2.1	0.3	0.2	-1.5	0.3	0.7	0.1	-0.0	-0.0	-0.5	0.2	0.4
Alcohol drinker status: Never	0.3	0.4	1.4	0.1	0.3	-0.9	1.2	0.2	0.5	1.0	0.1	0.1	0.4	-0.5
Ever smoked	0.4	0.7	4.2	-0.0	0.4	-0.5	1.0	-0.0	0.4	1.0	0.7	0.7	0.2	-2.1
Basal metabolic rate	0.4	2.0	11.1	-0.4	0.0	-2.5	1.7	-0.6	0.4	1.2	0.1	0.4	-0.1	-3.3
Leg fat percentage (left)	0.3	1.0	4.2	-1.1	-1.0	2.1	0.1	-1.3	-0.6	-0.1	-1.2	-0.5	-0.7	-0.9
Arm fat-free mass (left)	0.3	1.5	7.8	-0.5	-0.1	-2.2	1.4	-0.6	0.2	1.0	-0.1	0.1	-0.2	-2.8
Number of operations (self-reported)	1.3	1.9	5.5	-1.0	-1.1	2.4	-0.8	-0.5	-1.7	-1.6	-1.5	-1.6	-1.3	0.5
Average weekly beer plus cider intake	0.9	1.3	3.4	-0.7	-1.1	1.8	-0.5	-0.6	-1.1	-1.1	-1.2	-1.6	-1.4	0.7
Irritability	0.5	0.9	1.7	1.0	1.1	-0.9	0.4	0.9	1.3	1.0	1.2	0.6	0.9	0.5
Risk taking	1.0	1.4	2.9	1.0	1.4	-0.7	0.4	0.9	1.5	1.5	1.5	1.7	1.2	0.7
Ever had prostate specific antigen (PSA) test	3.3	3.8	7.1	1.5	2.0	-2.7	0.1	1.6	2.0	1.9	2.2	2.2	2.3	1.9
Fractured/broken bones in last 5 years	0.2	0.2	0.9	0.2	0.1	0.4	-1.0	0.0	0.2	-0.3	-0.0	0.3	0.3	0.9
Age started oral contraceptive pill	1.5	1.9	4.6	-1.0	-1.3	1.5	-1.4	-1.0	-1.4	-2.1	-1.3	-1.6	-1.5	-0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.7	-0.3	0.1	0.1	0.7	-0.1	0.5	0.8	0.0	0.4	0.2	-0.5
Ever depressed for a whole week	0.1	0.1	0.5	-0.1	-0.0	0.3	0.6	-0.1	0.1	0.5	-0.1	-0.1	-0.1	-0.7
Unable to work because of sickness or disability	1.4	1.9	5.2	1.0	0.7	0.5	2.3	0.6	1.4	2.0	0.3	1.1	1.6	1.9
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.5	0.2	-0.3	-0.2	0.5	-0.1	-0.5	0.2	-0.3	0.1	0.1
Myopia	1.1	1.5	3.9	-0.9	-0.9	1.2	-2.0	-0.8	-1.3	-2.0	-0.6	-0.8	-1.1	-1.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.6	-1.2	-1.0	1.0	-0.3	-1.1	-1.4	-1.0	-0.9	-0.6	-1.5	-1.9
Cholesterol lowering medication	0.1	0.2	0.5	0.6	0.2	-0.1	-0.2	0.4	0.2	-0.2	0.0	-0.2	0.7	0.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.8	0.9	1.2	-0.9	0.5	0.7	1.3	1.7	1.1	1.4	1.4	-0.2
Pain experienced in last month	0.5	0.8	1.7	-0.7	-0.9	0.5	0.6	-0.5	-0.9	-0.1	-1.1	-1.3	-1.2	-1.2
Supplements: Calcium	0.6	0.7	1.6	-0.5	-0.6	1.3	-0.8	-0.3	-1.0	-1.2	-0.5	-1.0	-0.8	-0.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.9	0.1	0.2	0.3	-0.1	-0.3	0.2	0.7	0.4	0.9	0.4	0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	-0.5	-0.0	0.2	-0.1	-0.3	0.2	0.2	0.2	0.6	0.3	0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.2	0.4	-0.0	0.4	-0.5	0.6	-0.2	-1.0	-0.1	-0.6	-0.1	1.1
Heart disease (siblings)	0.9	1.1	3.3	1.0	0.9	0.5	-1.8	0.9	0.7	-0.3	1.1	0.8	0.8	1.8
Alcohol drinker status: Previous	0.4	0.4	1.1	-0.5	-0.8	0.6	-0.3	-0.6	-0.7	-0.7	-1.0	-0.8	-0.3	-0.4
Pack years of smoking	1.6	2.3	4.5	0.9	1.4	-0.9	1.1	0.9	2.1	2.0	1.4	2.1	1.9	1.2
Impedance of whole body	1.3	6.5	9.7	-2.6	-2.6	3.1	-1.5	-2.2	-2.9	-2.7	-2.5	-2.9	-3.0	-1.5
Leg fat mass (left)	0.3	1.1	4.0	-1.3	-1.0	0.8	0.7	-1.4	-0.5	0.2	-1.1	-0.4	-0.7	-2.0
Arm predicted mass (left)	0.3	1.4	8.2	-0.8	-0.4	-1.9	1.2	-0.9	-0.1	0.7	-0.3	-0.1	-0.5	-2.9